22-22892198-G-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892198
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892198
    reference: chr 22
allele count: 1
allele frequency: 8.2917364554485e-6
allele num: 120602
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.855C>G
  hgvsp: ENST00000539862.1:c.855C>G(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.903C>G
  hgvsp: ENST00000398743.2:c.903C>G(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.903C>G
  hgvsp: ENST00000398741.1:c.903C>G(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1838C>G
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.855C>G
  hgvsp: ENST00000424204.2:c.855C>G(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.903C>G
  hgvsp: ENST00000405655.3:c.903C>G(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.903C>G
  hgvsp: ENST00000543184.1:c.903C>G(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.903C>G
  hgvsp: ENST00000402697.1:c.903C>G(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3104
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 147
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 194
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 368
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 75
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17046
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 117
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 50
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 625
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 58
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 296
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28283
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8901
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1289
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 8.25e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 45
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 52
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 71
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 11
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8518
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4035
  bin: 7.25e1
  variant carriers: 0
hgvs: p.Leu301Leu
num of homozygotes: 0
population: European (Finnish)
population: East Asian
population: South Asian
population: Latino
population: European (Non-Finnish)
population: African
population: Other
reference allele: G
site quality: ClippingRankSum
site quality: ReadPosRankSum
site quality: QD
site quality: DP
site quality: MQ
site quality: MQRankSum
site quality: FS
site quality: BaseQRankSum
site quality: InbreedingCoeff
site quality: VQSLOD

22-22892205-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892205
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892205
    reference: chr 22
allele count: 1
allele frequency: 8.269520202437855e-6
allele num: 120926
alternate allele: C
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.896A>G
  hgvsp: ENSP00000445675.1:p.Gln299Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.896A>G
  hgvsp: ENSP00000381726.1:p.Gln299Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.896A>G
  hgvsp: ENSP00000384343.3:p.Gln299Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.896A>G
  hgvsp: ENSP00000381728.2:p.Gln299Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.848A>G
  hgvsp: ENSP00000407342.2:p.Gln283Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.848A>G
  hgvsp: ENSP00000445097.1:p.Gln283Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.896A>G
  hgvsp: ENSP00000385198.1:p.Gln299Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1831A>G
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8961
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 61
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 50
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 30
  bin: 7.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 1298
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 297
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 94
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3114
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28338
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 74
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17221
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 213
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 58
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 148
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 629
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 47
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 255
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 27
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 41
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 2.5e0
  variant carriers: 0
hgvs: p.Gln299Arg
num of homozygotes: 0
population: East Asian
population: Other
population: European (Non-Finnish)
population: European (Finnish)
population: African
population: Latino
population: South Asian
reference allele: T
site quality: DP
site quality: InbreedingCoeff
site quality: VQSLOD
site quality: ReadPosRankSum
site quality: FS
site quality: ClippingRankSum
site quality: QD
site quality: MQ
site quality: BaseQRankSum
site quality: MQRankSum

22-22892207-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892207
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892207
    reference: chr 22
allele count: 1
allele frequency: 8.263506701703935e-6
allele num: 121014
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.846G>A
  hgvsp: ENST00000424204.2:c.846G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.894G>A
  hgvsp: ENST00000398741.1:c.894G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1829G>A
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.894G>A
  hgvsp: ENST00000405655.3:c.894G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.846G>A
  hgvsp: ENST00000539862.1:c.846G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.894G>A
  hgvsp: ENST00000398743.2:c.894G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.894G>A
  hgvsp: ENST00000543184.1:c.894G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.894G>A
  hgvsp: ENST00000402697.1:c.894G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 8.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 58
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28295
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 74
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 81
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 150
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 297
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 168
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17270
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 56
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 50
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1311
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3119
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8994
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 633
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 42
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 32
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 40
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5200
  bin: 7.75e1
  variant carriers: 0
hgvs: p.Leu298Leu
num of homozygotes: 0
population: South Asian
population: African
population: Other
population: Latino
population: European (Finnish)
population: East Asian
population: European (Non-Finnish)
reference allele: C
site quality: QD
site quality: FS
site quality: MQ
site quality: MQRankSum
site quality: VQSLOD
site quality: DP
site quality: InbreedingCoeff
site quality: BaseQRankSum
site quality: ReadPosRankSum
site quality: ClippingRankSum

22-22892216-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892216
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892216
    reference: chr 22
allele count: 1
allele frequency: 8.253821519363466e-6
allele num: 121156
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.885G>A
  hgvsp: ENST00000398741.1:c.885G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.885G>A
  hgvsp: ENST00000402697.1:c.885G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.837G>A
  hgvsp: ENST00000539862.1:c.837G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.837G>A
  hgvsp: ENST00000424204.2:c.837G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1820G>A
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.885G>A
  hgvsp: ENST00000405655.3:c.885G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.885G>A
  hgvsp: ENST00000398743.2:c.885G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.885G>A
  hgvsp: ENST00000543184.1:c.885G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 47
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3128
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 58
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 44
  bin: 7.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 17376
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 149
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 97
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28271
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 50
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 632
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1314
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 74
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9029
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 298
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 30720
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5216
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 15
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 16
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1708
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 1.25e1
  variant carriers: 0
hgvs: p.Leu295Leu
num of homozygotes: 0
population: East Asian
population: Latino
population: European (Finnish)
population: Other
population: European (Non-Finnish)
population: African
population: South Asian
reference allele: C
site quality: MQRankSum
site quality: ClippingRankSum
site quality: InbreedingCoeff
site quality: QD
site quality: VQSLOD
site quality: ReadPosRankSum
site quality: DP
site quality: MQ
site quality: FS
site quality: BaseQRankSum

22-22892225-G-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892225
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892225
    reference: chr 22
allele count: 1
allele frequency: 8.248375070111188e-6
allele num: 121236
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.876C>G
  hgvsp: ENSP00000385198.1:p.Phe292Leu
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.828C>G
  hgvsp: ENSP00000407342.2:p.Phe276Leu
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.876C>G
  hgvsp: ENSP00000381728.2:p.Phe292Leu
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.876C>G
  hgvsp: ENSP00000445675.1:p.Phe292Leu
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.876C>G
  hgvsp: ENSP00000384343.3:p.Phe292Leu
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1811C>G
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.876C>G
  hgvsp: ENSP00000381726.1:p.Phe292Leu
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.828C>G
  hgvsp: ENSP00000445097.1:p.Phe276Leu
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 28284
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 65
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 150
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 74
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 635
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17417
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 59
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1311
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 298
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 30
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 50
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9041
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 8.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3124
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 11
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1710
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3625
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 4.75e1
  variant carriers: 0
hgvs: p.Phe292Leu
num of homozygotes: 0
population: African
population: East Asian
population: European (Finnish)
population: Other
population: European (Non-Finnish)
population: Latino
population: South Asian
reference allele: G
site quality: FS
site quality: ClippingRankSum
site quality: QD
site quality: InbreedingCoeff
site quality: ReadPosRankSum
site quality: BaseQRankSum
site quality: DP
site quality: VQSLOD
site quality: MQRankSum
site quality: MQ

http://identifiers.org/exac.variant/22-22892228-C-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892228
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892228
    reference: chr 22
allele count: 1
allele frequency: 8.246470510621453e-6
allele num: 121264
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.873G>T
  hgvsp: ENSP00000385198.1:p.Gln291His
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.825G>T
  hgvsp: ENSP00000407342.2:p.Gln275His
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.873G>T
  hgvsp: ENSP00000381728.2:p.Gln291His
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.873G>T
  hgvsp: ENSP00000445675.1:p.Gln291His
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1808G>T
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.873G>T
  hgvsp: ENSP00000381726.1:p.Gln291His
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.873G>T
  hgvsp: ENSP00000384343.3:p.Gln291His
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.825G>T
  hgvsp: ENSP00000445097.1:p.Gln275His
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 28285
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 50
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 53
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 9.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 59
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17431
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 151
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 637
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9041
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 298
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 74
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1311
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3123
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3629
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 10
  bin: 7.5e0
  variant carriers: 0
hgvs: p.Gln291His
num of homozygotes: 0
population: Other
population: East Asian
population: European (Finnish)
population: Latino
population: African
population: South Asian
population: European (Non-Finnish)
reference allele: C
site quality: BaseQRankSum
site quality: QD
site quality: VQSLOD
site quality: MQ
site quality: DP
site quality: ReadPosRankSum
site quality: ClippingRankSum
site quality: MQRankSum
site quality: FS
site quality: InbreedingCoeff

22-22892240-C-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892240
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892240
    reference: chr 22
allele count: 1
allele frequency: 8.243207596940122e-6
allele num: 121312
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.861G>C
  hgvsp: ENSP00000385198.1:p.Gln287His
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.813G>C
  hgvsp: ENSP00000407342.2:p.Gln271His
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.861G>C
  hgvsp: ENSP00000445675.1:p.Gln287His
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1796G>C
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.861G>C
  hgvsp: ENSP00000384343.3:p.Gln287His
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.861G>C
  hgvsp: ENSP00000381726.1:p.Gln287His
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.813G>C
  hgvsp: ENSP00000445097.1:p.Gln271His
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.861G>C
  hgvsp: ENSP00000381728.2:p.Gln287His
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 16
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 151
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28286
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 298
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17449
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 637
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 74
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 51
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3127
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 60
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1314
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9050
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 10
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1949
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 38
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4543
  bin: 9.75e1
  variant carriers: 1
hgvs: p.Gln287His
num of homozygotes: 0
population: East Asian
population: European (Finnish)
population: Latino
population: African
population: South Asian
population: European (Non-Finnish)
population: Other
reference allele: C
site quality: QD
site quality: VQSLOD
site quality: DP
site quality: ReadPosRankSum
site quality: ClippingRankSum
site quality: MQRankSum
site quality: BaseQRankSum
site quality: InbreedingCoeff
site quality: MQ
site quality: FS

22-22892244-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892244
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892244
    reference: chr 22
allele count: 1
allele frequency: 8.242664029014178e-6
allele num: 121320
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.857C>T
  hgvsp: ENSP00000381728.2:p.Ala286Val
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.857C>T
  hgvsp: ENSP00000385198.1:p.Ala286Val
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1792C>T
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.809C>T
  hgvsp: ENSP00000445097.1:p.Ala270Val
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.857C>T
  hgvsp: ENSP00000384343.3:p.Ala286Val
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.857C>T
  hgvsp: ENSP00000381726.1:p.Ala286Val
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.857C>T
  hgvsp: ENSP00000445675.1:p.Ala286Val
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.809C>T
  hgvsp: ENSP00000407342.2:p.Ala270Val
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 9047
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 298
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3125
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28285
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17460
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1314
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 636
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 51
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 74
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 152
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 60
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1711
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5219
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4544
  bin: 9.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 4075
  bin: 7.25e1
  variant carriers: 0
hgvs: p.Ala286Val
num of homozygotes: 0
population: Latino
population: African
population: European (Non-Finnish)
population: South Asian
population: European (Finnish)
population: Other
population: East Asian
reference allele: G
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: DP
site quality: QD
site quality: MQRankSum
site quality: ReadPosRankSum
site quality: FS
site quality: VQSLOD
site quality: MQ
site quality: InbreedingCoeff

22-22892245-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892245
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892245
    reference: chr 22
allele count: 1
allele frequency: 8.242664029014178e-6
allele num: 121320
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.808G>A
  hgvsp: ENSP00000445097.1:p.Ala270Thr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.856G>A
  hgvsp: ENSP00000381728.2:p.Ala286Thr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.856G>A
  hgvsp: ENSP00000385198.1:p.Ala286Thr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.856G>A
  hgvsp: ENSP00000384343.3:p.Ala286Thr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.856G>A
  hgvsp: ENSP00000445675.1:p.Ala286Thr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1791G>A
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.856G>A
  hgvsp: ENSP00000381726.1:p.Ala286Thr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.808G>A
  hgvsp: ENSP00000407342.2:p.Ala270Thr
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: VQSRTrancheINDEL99.50to99.90
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17465
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9047
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3125
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28281
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1314
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 51
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 152
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 298
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 60
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 637
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 74
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 36
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4544
  bin: 9.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 7
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8644
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1711
  bin: 8.75e1
  variant carriers: 0
hgvs: p.Ala286Thr
num of homozygotes: 0
population: European (Non-Finnish)
population: African
population: Latino
population: South Asian
population: Other
population: East Asian
population: European (Finnish)
reference allele: C
site quality: VQSLOD
site quality: MQ
site quality: DP
site quality: MQRankSum
site quality: ClippingRankSum
site quality: InbreedingCoeff
site quality: FS
site quality: BaseQRankSum
site quality: QD
site quality: ReadPosRankSum

22-22892246-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892246
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892246
    reference: chr 22
allele count: 1
allele frequency: 8.242256400112095e-6
allele num: 121326
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.855C>T
  hgvsp: ENST00000402697.1:c.855C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.855C>T
  hgvsp: ENST00000405655.3:c.855C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.855C>T
  hgvsp: ENST00000398743.2:c.855C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1790C>T
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.855C>T
  hgvsp: ENST00000398741.1:c.855C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.855C>T
  hgvsp: ENST00000543184.1:c.855C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.807C>T
  hgvsp: ENST00000539862.1:c.807C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.807C>T
  hgvsp: ENST00000424204.2:c.807C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 17464
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3125
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 74
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 152
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 637
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 24
  bin: 8.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28285
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1313
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 298
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 60
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 51
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9050
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 31
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4545
  bin: 9.75e1
  variant carriers: 1
hgvs: p.Ile285Ile
num of homozygotes: 0
population: Latino
population: South Asian
population: European (Finnish)
population: East Asian
population: Other
population: African
population: European (Non-Finnish)
reference allele: G
site quality: ReadPosRankSum
site quality: QD
site quality: FS
site quality: MQRankSum
site quality: ClippingRankSum
site quality: VQSLOD
site quality: BaseQRankSum
site quality: MQ
site quality: InbreedingCoeff
site quality: DP

22-22892250-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892250
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892250
    reference: chr 22
allele count: 4
allele frequency: 3.296956908773203e-5
allele num: 121324
alternate allele: C
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.851A>G
  hgvsp: ENSP00000445675.1:p.Tyr284Cys
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.851A>G
  hgvsp: ENSP00000381728.2:p.Tyr284Cys
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.851A>G
  hgvsp: ENSP00000381726.1:p.Tyr284Cys
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.803A>G
  hgvsp: ENSP00000445097.1:p.Tyr268Cys
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.803A>G
  hgvsp: ENSP00000407342.2:p.Tyr268Cys
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.851A>G
  hgvsp: ENSP00000384343.3:p.Tyr284Cys
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1786A>G
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.851A>G
  hgvsp: ENSP00000385198.1:p.Tyr284Cys
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 17467
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28280
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 152
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 9.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 60
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1314
  bin: 4.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 9050
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 52
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 3125
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 637
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 44
  bin: 7.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 74
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 298
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4079
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 29
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 7
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8647
  bin: 6.75e1
  variant carriers: 0
hgvs: p.Tyr284Cys
num of homozygotes: 0
population: East Asian
population: South Asian
population: African
population: European (Non-Finnish)
population: Latino
population: Other
population: European (Finnish)
reference allele: T
site quality: ReadPosRankSum
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: QD
site quality: MQ
site quality: VQSLOD
site quality: DP
site quality: FS
site quality: BaseQRankSum
site quality: ClippingRankSum

22-22892255-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892255
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892255
    reference: chr 22
allele count: 591
allele frequency: 4.871012939915932e-3
allele num: 121330
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.846G>A
  hgvsp: ENST00000398743.2:c.846G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.798G>A
  hgvsp: ENST00000424204.2:c.798G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.798G>A
  hgvsp: ENST00000539862.1:c.798G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1781G>A
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.846G>A
  hgvsp: ENST00000402697.1:c.846G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.846G>A
  hgvsp: ENST00000398741.1:c.846G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.846G>A
  hgvsp: ENST00000405655.3:c.846G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.846G>A
  hgvsp: ENST00000543184.1:c.846G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 1312
  bin: 4.25e1
  variant carriers: 5
genotype depth: GenotypeDepth
  all individuals: 313
  bin: 5.25e1
  variant carriers: 18
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 8.25e1
  variant carriers: 34
genotype depth: GenotypeDepth
  all individuals: 16
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 50
  bin: 8.75e1
  variant carriers: 33
genotype depth: GenotypeDepth
  all individuals: 71
  bin: 7.25e1
  variant carriers: 29
genotype depth: GenotypeDepth
  all individuals: 24
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 96
  bin: 6.25e1
  variant carriers: 25
genotype depth: GenotypeDepth
  all individuals: 17307
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8961
  bin: 3.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 28023
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 643
  bin: 4.75e1
  variant carriers: 13
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3090
  bin: 3.75e1
  variant carriers: 4
genotype depth: GenotypeDepth
  all individuals: 336
  bin: 9.75e1
  variant carriers: 289
genotype depth: GenotypeDepth
  all individuals: 175
  bin: 5.75e1
  variant carriers: 26
genotype depth: GenotypeDepth
  all individuals: 56
  bin: 9.25e1
  variant carriers: 47
genotype depth: GenotypeDepth
  all individuals: 88
  bin: 6.75e1
  variant carriers: 30
genotype depth: GenotypeDepth
  all individuals: 62
  bin: 7.75e1
  variant carriers: 33
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8571
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 30581
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 26
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 1.75e1
  variant carriers: 0
hgvs: p.Glu282Glu
num of homozygotes: 4
population: European (Non-Finnish)
population: East Asian
population: African
population: South Asian
population: Latino
population: European (Finnish)
population: Other
reference allele: C
site quality: MQRankSum
site quality: FS
site quality: ClippingRankSum
site quality: BaseQRankSum
site quality: QD
site quality: DP
site quality: MQ
site quality: VQSLOD
site quality: InbreedingCoeff
site quality: ReadPosRankSum

22-22892256-T-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892256
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892256
    reference: chr 22
allele count: 1
allele frequency: 8.241984669908513e-6
allele num: 121330
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1780A>C
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.797A>C
  hgvsp: ENSP00000445097.1:p.Glu266Ala
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.845A>C
  hgvsp: ENSP00000385198.1:p.Glu282Ala
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.845A>C
  hgvsp: ENSP00000384343.3:p.Glu282Ala
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.797A>C
  hgvsp: ENSP00000407342.2:p.Glu266Ala
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.845A>C
  hgvsp: ENSP00000445675.1:p.Glu282Ala
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.845A>C
  hgvsp: ENSP00000381728.2:p.Glu282Ala
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.845A>C
  hgvsp: ENSP00000381726.1:p.Glu282Ala
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: VQSRTrancheSNP99.60to99.80
genotype depth: GenotypeDepth
  all individuals: 99
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3126
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 46
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 67
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9003
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 207
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 70
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 701
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28040
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17354
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 111
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 358
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1380
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 30645
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4044
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5166
  bin: 7.75e1
  variant carriers: 0
hgvs: p.Glu282Ala
num of homozygotes: 0
population: European (Finnish)
population: European (Non-Finnish)
population: Other
population: African
population: Latino
population: East Asian
population: South Asian
reference allele: T
site quality: QD
site quality: FS
site quality: MQ
site quality: VQSLOD
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: ReadPosRankSum
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: DP

22-22892260-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892260
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892260
    reference: chr 22
allele count: 2
allele frequency: 1.648315421639085e-5
allele num: 121336
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.841G>A
  hgvsp: ENSP00000385198.1:p.Glu281Lys
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1776G>A
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.841G>A
  hgvsp: ENSP00000445675.1:p.Glu281Lys
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.841G>A
  hgvsp: ENSP00000381728.2:p.Glu281Lys
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.841G>A
  hgvsp: ENSP00000381726.1:p.Glu281Lys
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.841G>A
  hgvsp: ENSP00000384343.3:p.Glu281Lys
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.793G>A
  hgvsp: ENSP00000407342.2:p.Glu265Lys
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.793G>A
  hgvsp: ENSP00000445097.1:p.Glu265Lys
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 28035
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 67
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 358
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 9.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17355
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 99
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 208
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9004
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1380
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3127
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 47
  bin: 7.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 69
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 700
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 111
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 30645
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 7
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8585
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1710
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1951
  bin: 9.25e1
  variant carriers: 0
hgvs: p.Glu281Lys
num of homozygotes: 0
population: African
population: Other
population: South Asian
population: European (Finnish)
population: Latino
population: European (Non-Finnish)
population: East Asian
reference allele: C
site quality: DP
site quality: MQRankSum
site quality: ReadPosRankSum
site quality: BaseQRankSum
site quality: FS
site quality: MQ
site quality: InbreedingCoeff
site quality: VQSLOD
site quality: QD
site quality: ClippingRankSum

http://identifiers.org/exac.variant/22-22892266-C-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892266
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892266
    reference: chr 22
allele count: 1
allele frequency: 8.241441263248117e-6
allele num: 121338
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: stop_gained
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.835G>T
  hgvsp: ENSP00000384343.3:p.Glu279Ter
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: stop_gained
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.835G>T
  hgvsp: ENSP00000381726.1:p.Glu279Ter
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: stop_gained
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.835G>T
  hgvsp: ENSP00000385198.1:p.Glu279Ter
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: stop_gained
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.787G>T
  hgvsp: ENSP00000445097.1:p.Glu263Ter
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: stop_gained
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.835G>T
  hgvsp: ENSP00000445675.1:p.Glu279Ter
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: stop_gained
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.787G>T
  hgvsp: ENSP00000407342.2:p.Glu263Ter
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: stop_gained
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.835G>T
  hgvsp: ENSP00000381728.2:p.Glu279Ter
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1770G>T
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: stop gained
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 99
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 47
  bin: 7.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9002
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17362
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1380
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 208
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 702
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 111
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 358
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28035
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 69
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3127
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 67
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 30649
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4907
  bin: 9.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 22
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 7
  bin: 7.5e0
  variant carriers: 0
hgvs: p.Glu279Ter
num of homozygotes: 0
population: Other
population: South Asian
population: European (Non-Finnish)
population: Latino
population: European (Finnish)
population: East Asian
population: African
reference allele: C
site quality: BaseQRankSum
site quality: MQ
site quality: MQRankSum
site quality: DP
site quality: FS
site quality: VQSLOD
site quality: InbreedingCoeff
site quality: ClippingRankSum
site quality: QD
site quality: ReadPosRankSum

22-22892267-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892267
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892267
    reference: chr 22
allele count: 6
allele frequency: 4.94486475794887e-5
allele num: 121338
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.786G>A
  hgvsp: ENST00000539862.1:c.786G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.834G>A
  hgvsp: ENST00000405655.3:c.834G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.834G>A
  hgvsp: ENST00000543184.1:c.834G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.834G>A
  hgvsp: ENST00000398741.1:c.834G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.834G>A
  hgvsp: ENST00000398743.2:c.834G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1769G>A
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.834G>A
  hgvsp: ENST00000402697.1:c.834G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.786G>A
  hgvsp: ENST00000424204.2:c.786G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 9002
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1381
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 101
  bin: 6.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17363
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 68
  bin: 7.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 112
  bin: 6.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 71
  bin: 9.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 208
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 358
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3129
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 45
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 702
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28028
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1710
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 1.25e1
  variant carriers: 0
hgvs: p.Pro278Pro
num of homozygotes: 0
population: Latino
population: East Asian
population: Other
population: African
population: European (Non-Finnish)
population: European (Finnish)
population: South Asian
reference allele: C
site quality: FS
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: BaseQRankSum
site quality: ReadPosRankSum
site quality: MQ
site quality: QD
site quality: VQSLOD
site quality: ClippingRankSum
site quality: DP

22-22892268-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892268
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892268
    reference: chr 22
allele count: 9
allele frequency: 7.417419397375882e-5
allele num: 121336
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.833C>T
  hgvsp: ENSP00000385198.1:p.Pro278Leu
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.833C>T
  hgvsp: ENSP00000381728.2:p.Pro278Leu
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.833C>T
  hgvsp: ENSP00000384343.3:p.Pro278Leu
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1768C>T
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.785C>T
  hgvsp: ENSP00000445097.1:p.Pro262Leu
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.833C>T
  hgvsp: ENSP00000445675.1:p.Pro278Leu
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.833C>T
  hgvsp: ENSP00000381726.1:p.Pro278Leu
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.785C>T
  hgvsp: ENSP00000407342.2:p.Pro262Leu
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 703
  bin: 4.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 357
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28023
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 76
  bin: 9.75e1
  variant carriers: 7
genotype depth: GenotypeDepth
  all individuals: 1382
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 100
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3132
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 208
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9004
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 112
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 67
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 45
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17359
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1953
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 7
  bin: 4.75e1
  variant carriers: 0
hgvs: p.Pro278Leu
num of homozygotes: 0
population: Other
population: South Asian
population: European (Finnish)
population: East Asian
population: African
population: European (Non-Finnish)
population: Latino
reference allele: G
site quality: InbreedingCoeff
site quality: VQSLOD
site quality: QD
site quality: FS
site quality: DP
site quality: MQ
site quality: ReadPosRankSum
site quality: ClippingRankSum
site quality: MQRankSum
site quality: BaseQRankSum

22-22892269-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892269
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892269
    reference: chr 22
allele count: 1
allele frequency: 8.241712957621112e-6
allele num: 121334
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.832C>T
  hgvsp: ENSP00000385198.1:p.Pro278Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.784C>T
  hgvsp: ENSP00000445097.1:p.Pro262Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.832C>T
  hgvsp: ENSP00000384343.3:p.Pro278Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.832C>T
  hgvsp: ENSP00000445675.1:p.Pro278Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.832C>T
  hgvsp: ENSP00000381726.1:p.Pro278Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.784C>T
  hgvsp: ENSP00000407342.2:p.Pro262Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.832C>T
  hgvsp: ENSP00000381728.2:p.Pro278Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1767C>T
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 210
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 701
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17361
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9003
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 100
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1382
  bin: 4.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 114
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3133
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 357
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28024
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 67
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 69
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 46
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1712
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 7
  bin: 5.25e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 3
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3621
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 2.5e0
  variant carriers: 0
hgvs: p.Pro278Ser
num of homozygotes: 0
population: European (Non-Finnish)
population: African
population: Other
population: European (Finnish)
population: East Asian
population: Latino
population: South Asian
reference allele: G
site quality: ClippingRankSum
site quality: QD
site quality: MQ
site quality: MQRankSum
site quality: VQSLOD
site quality: BaseQRankSum
site quality: FS
site quality: ReadPosRankSum
site quality: DP
site quality: InbreedingCoeff

22-22892270-G-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892270
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892270
    reference: chr 22
allele count: 1
allele frequency: 8.241577108195424e-6
allele num: 121336
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.831C>A
  hgvsp: ENST00000402697.1:c.831C>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.783C>A
  hgvsp: ENST00000539862.1:c.783C>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.783C>A
  hgvsp: ENST00000424204.2:c.783C>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.831C>A
  hgvsp: ENST00000405655.3:c.831C>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.831C>A
  hgvsp: ENST00000398743.2:c.831C>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.831C>A
  hgvsp: ENST00000543184.1:c.831C>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1766C>A
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.831C>A
  hgvsp: ENST00000398741.1:c.831C>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 210
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 357
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28027
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 114
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17359
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 701
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3133
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1381
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 69
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 46
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 67
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 100
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9003
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32
  bin: 8.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 5
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5168
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 2.5e0
  variant carriers: 0
hgvs: p.Ser277Ser
num of homozygotes: 0
population: Latino
population: European (Finnish)
population: European (Non-Finnish)
population: East Asian
population: African
population: South Asian
population: Other
reference allele: G
site quality: MQRankSum
site quality: QD
site quality: FS
site quality: ClippingRankSum
site quality: MQ
site quality: DP
site quality: ReadPosRankSum
site quality: InbreedingCoeff
site quality: BaseQRankSum
site quality: VQSLOD

22-22892274-A-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892274
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892274
    reference: chr 22
allele count: 1
allele frequency: 8.241577108195424e-6
allele num: 121336
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.827T>C
  hgvsp: ENSP00000385198.1:p.Ile276Thr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.827T>C
  hgvsp: ENSP00000381726.1:p.Ile276Thr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.827T>C
  hgvsp: ENSP00000445675.1:p.Ile276Thr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.779T>C
  hgvsp: ENSP00000445097.1:p.Ile260Thr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.779T>C
  hgvsp: ENSP00000407342.2:p.Ile260Thr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.827T>C
  hgvsp: ENSP00000381728.2:p.Ile276Thr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1762T>C
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.827T>C
  hgvsp: ENSP00000384343.3:p.Ile276Thr
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 702
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 357
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 100
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9001
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 46
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 210
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 114
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17357
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3133
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28031
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1382
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 70
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 67
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 7
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5165
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 22
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3
  bin: 4.25e1
  variant carriers: 0
hgvs: p.Ile276Thr
num of homozygotes: 0
population: East Asian
population: European (Non-Finnish)
population: European (Finnish)
population: Other
population: Latino
population: African
population: South Asian
reference allele: A
site quality: MQRankSum
site quality: FS
site quality: VQSLOD
site quality: QD
site quality: BaseQRankSum
site quality: ReadPosRankSum
site quality: InbreedingCoeff
site quality: MQ
site quality: ClippingRankSum
site quality: DP

22-22892277-T-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892277
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892277
    reference: chr 22
allele count: 1
allele frequency: 8.241441263248117e-6
allele num: 121338
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.824A>T
  hgvsp: ENSP00000381728.2:p.Tyr275Phe
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.824A>T
  hgvsp: ENSP00000445675.1:p.Tyr275Phe
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1759A>T
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.776A>T
  hgvsp: ENSP00000407342.2:p.Tyr259Phe
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.824A>T
  hgvsp: ENSP00000384343.3:p.Tyr275Phe
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.824A>T
  hgvsp: ENSP00000385198.1:p.Tyr275Phe
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.776A>T
  hgvsp: ENSP00000445097.1:p.Tyr259Phe
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.824A>T
  hgvsp: ENSP00000381726.1:p.Tyr275Phe
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 100
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 357
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 702
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 114
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3136
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9003
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 47
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1380
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 69
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 211
  bin: 5.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 17356
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 67
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28029
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1713
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6
  bin: 7.5e0
  variant carriers: 0
hgvs: p.Tyr275Phe
num of homozygotes: 0
population: South Asian
population: African
population: Latino
population: European (Non-Finnish)
population: European (Finnish)
population: East Asian
population: Other
reference allele: T
site quality: FS
site quality: MQRankSum
site quality: QD
site quality: ReadPosRankSum
site quality: VQSLOD
site quality: InbreedingCoeff
site quality: ClippingRankSum
site quality: DP
site quality: MQ
site quality: BaseQRankSum

22-22892282-A-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892282
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892282
    reference: chr 22
allele count: 1
allele frequency: 8.241441263248117e-6
allele num: 121338
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.819T>C
  hgvsp: ENST00000402697.1:c.819T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.819T>C
  hgvsp: ENST00000398743.2:c.819T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.771T>C
  hgvsp: ENST00000424204.2:c.771T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.771T>C
  hgvsp: ENST00000539862.1:c.771T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.819T>C
  hgvsp: ENST00000405655.3:c.819T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1754T>C
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.819T>C
  hgvsp: ENST00000398741.1:c.819T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.819T>C
  hgvsp: ENST00000543184.1:c.819T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 17360
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 69
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3137
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 114
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28023
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1379
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 47
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 210
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9002
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 357
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 702
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 68
  bin: 7.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 100
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1954
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8585
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9
  bin: 3.25e1
  variant carriers: 0
hgvs: p.Ser273Ser
num of homozygotes: 0
population: African
population: South Asian
population: European (Non-Finnish)
population: East Asian
population: Other
population: European (Finnish)
population: Latino
reference allele: A
site quality: ClippingRankSum
site quality: FS
site quality: InbreedingCoeff
site quality: QD
site quality: BaseQRankSum
site quality: ReadPosRankSum
site quality: VQSLOD
site quality: MQ
site quality: DP
site quality: MQRankSum

22-22892283-G-GATGC
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892283
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892287
    reference: chr 22
allele count: 1
allele frequency: 8.241305422778968e-6
allele num: 121340
alternate allele: GATGC
annotation: Annotation
  canonical: false
  consequence: frameshift_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.814_817dupGCAT
  hgvsp: ENSP00000381726.1:p.Ser273CysfsTer39
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: frameshift_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.814_817dupGCAT
  hgvsp: ENSP00000384343.3:p.Ser273CysfsTer39
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: frameshift_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.814_817dupGCAT
  hgvsp: ENSP00000385198.1:p.Ser273CysfsTer39
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: frameshift_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.814_817dupGCAT
  hgvsp: ENSP00000381728.2:p.Ser273CysfsTer39
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: frameshift_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.766_769dupGCAT
  hgvsp: ENSP00000407342.2:p.Ser257CysfsTer39
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: frameshift_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.766_769dupGCAT
  hgvsp: ENSP00000445097.1:p.Ser257CysfsTer39
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: frameshift_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.814_817dupGCAT
  hgvsp: ENSP00000445675.1:p.Ser273CysfsTer39
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1749_1752dupGCAT
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: frameshift
filter: VQSRTrancheINDEL95.00to96.00
genotype depth: GenotypeDepth
  all individuals: 9001
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17360
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28022
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 67
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 47
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1379
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 357
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 701
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 100
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 114
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3138
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 211
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 70
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1712
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 22
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 7
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8585
  bin: 6.75e1
  variant carriers: 0
hgvs: p.Ser273CysfsTer39
num of homozygotes: 0
population: African
population: European (Finnish)
population: Other
population: Latino
population: South Asian
population: European (Non-Finnish)
population: East Asian
reference allele: G
site quality: VQSLOD
site quality: ClippingRankSum
site quality: FS
site quality: BaseQRankSum
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: DP
site quality: QD
site quality: MQ
site quality: ReadPosRankSum

22-22892285-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892285
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892285
    reference: chr 22
allele count: 1
allele frequency: 8.241305422778968e-6
allele num: 121340
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.768A>G
  hgvsp: ENST00000539862.1:c.768A>G(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.816A>G
  hgvsp: ENST00000398741.1:c.816A>G(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.816A>G
  hgvsp: ENST00000402697.1:c.816A>G(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.816A>G
  hgvsp: ENST00000543184.1:c.816A>G(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.816A>G
  hgvsp: ENST00000405655.3:c.816A>G(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.768A>G
  hgvsp: ENST00000424204.2:c.768A>G(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.816A>G
  hgvsp: ENST00000398743.2:c.816A>G(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1751A>G
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 47
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9005
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 101
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 357
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 114
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 701
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28015
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1380
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 211
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3138
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 67
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17359
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 70
  bin: 9.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4916
  bin: 9.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 10
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5167
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 1.25e1
  variant carriers: 0
hgvs: p.Ala272Ala
num of homozygotes: 0
population: African
population: Latino
population: East Asian
population: European (Non-Finnish)
population: European (Finnish)
population: Other
population: South Asian
reference allele: T
site quality: FS
site quality: BaseQRankSum
site quality: VQSLOD
site quality: ClippingRankSum
site quality: MQRankSum
site quality: DP
site quality: QD
site quality: InbreedingCoeff
site quality: MQ
site quality: ReadPosRankSum

http://identifiers.org/exac.variant/22-22892288-A-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892288
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892288
    reference: chr 22
allele count: 1
allele frequency: 8.241441263248117e-6
allele num: 121338
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.813T>G
  hgvsp: ENSP00000385198.1:p.His271Gln
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.813T>G
  hgvsp: ENSP00000445675.1:p.His271Gln
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.813T>G
  hgvsp: ENSP00000381728.2:p.His271Gln
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.813T>G
  hgvsp: ENSP00000384343.3:p.His271Gln
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.765T>G
  hgvsp: ENSP00000407342.2:p.His255Gln
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1748T>G
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.813T>G
  hgvsp: ENSP00000381726.1:p.His271Gln
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.765T>G
  hgvsp: ENSP00000445097.1:p.His255Gln
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 17362
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9001
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 212
  bin: 5.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 48
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1379
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 67
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 357
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 71
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 115
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28008
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 101
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3140
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 701
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1713
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1954
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5164
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 7.5e0
  variant carriers: 0
hgvs: p.His271Gln
num of homozygotes: 0
population: Latino
population: East Asian
population: European (Non-Finnish)
population: Other
population: European (Finnish)
population: African
population: South Asian
reference allele: A
site quality: DP
site quality: BaseQRankSum
site quality: ReadPosRankSum
site quality: FS
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: MQ
site quality: ClippingRankSum
site quality: VQSLOD
site quality: QD

22-22892288-A-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892288
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892288
    reference: chr 22
allele count: 5
allele frequency: 4.120720631624058e-5
allele num: 121338
alternate allele: G
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.813T>C
  hgvsp: ENST00000543184.1:c.813T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.813T>C
  hgvsp: ENST00000398741.1:c.813T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.813T>C
  hgvsp: ENST00000402697.1:c.813T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1748T>C
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.765T>C
  hgvsp: ENST00000539862.1:c.765T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.813T>C
  hgvsp: ENST00000405655.3:c.813T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.765T>C
  hgvsp: ENST00000424204.2:c.765T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.813T>C
  hgvsp: ENST00000398743.2:c.813T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 1379
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 67
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 357
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 701
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17362
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 101
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9001
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 115
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 212
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 9.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 8.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 71
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 48
  bin: 7.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 28008
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3140
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 10
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4038
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6
  bin: 4.75e1
  variant carriers: 0
hgvs: p.His271His
num of homozygotes: 0
population: Latino
population: European (Finnish)
population: Other
population: South Asian
population: European (Non-Finnish)
population: African
population: East Asian
reference allele: A
site quality: InbreedingCoeff
site quality: ClippingRankSum
site quality: ReadPosRankSum
site quality: BaseQRankSum
site quality: QD
site quality: DP
site quality: MQ
site quality: VQSLOD
site quality: FS
site quality: MQRankSum

22-22892291-G-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892291
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892291
    reference: chr 22
allele count: 1
allele frequency: 8.241169586787756e-6
allele num: 121342
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.762C>G
  hgvsp: ENSP00000407342.2:p.Ile254Met
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.810C>G
  hgvsp: ENSP00000385198.1:p.Ile270Met
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.762C>G
  hgvsp: ENSP00000445097.1:p.Ile254Met
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.810C>G
  hgvsp: ENSP00000445675.1:p.Ile270Met
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.810C>G
  hgvsp: ENSP00000384343.3:p.Ile270Met
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.810C>G
  hgvsp: ENSP00000381728.2:p.Ile270Met
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.810C>G
  hgvsp: ENSP00000381726.1:p.Ile270Met
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1745C>G
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 358
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17365
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 102
  bin: 6.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3142
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 700
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28000
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 67
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9002
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 116
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 211
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1382
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 47
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 69
  bin: 9.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3622
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 10
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1955
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 22
  bin: 2.25e1
  variant carriers: 0
hgvs: p.Ile270Met
num of homozygotes: 0
population: East Asian
population: African
population: European (Non-Finnish)
population: Latino
population: European (Finnish)
population: Other
population: South Asian
reference allele: G
site quality: QD
site quality: MQ
site quality: BaseQRankSum
site quality: InbreedingCoeff
site quality: ClippingRankSum
site quality: FS
site quality: VQSLOD
site quality: MQRankSum
site quality: ReadPosRankSum
site quality: DP

22-22892298-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892298
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892298
    reference: chr 22
allele count: 11
allele frequency: 9.065137130801688e-5
allele num: 121344
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.803C>T
  hgvsp: ENSP00000381726.1:p.Ser268Phe
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.803C>T
  hgvsp: ENSP00000445675.1:p.Ser268Phe
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.803C>T
  hgvsp: ENSP00000381728.2:p.Ser268Phe
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.803C>T
  hgvsp: ENSP00000384343.3:p.Ser268Phe
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.803C>T
  hgvsp: ENSP00000385198.1:p.Ser268Phe
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.755C>T
  hgvsp: ENSP00000445097.1:p.Ser252Phe
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.755C>T
  hgvsp: ENSP00000407342.2:p.Ser252Phe
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1738C>T
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 67
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 116
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27985
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 359
  bin: 5.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32
  bin: 8.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 101
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9004
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 215
  bin: 5.75e1
  variant carriers: 4
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1381
  bin: 4.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 701
  bin: 4.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 48
  bin: 7.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 3143
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17366
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 71
  bin: 9.75e1
  variant carriers: 2
genotype quality: GenotypeQuality
  all individuals: 11
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1957
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3
  bin: 4.25e1
  variant carriers: 0
hgvs: p.Ser268Phe
num of homozygotes: 0
population: East Asian
population: Latino
population: European (Finnish)
population: South Asian
population: African
population: European (Non-Finnish)
population: Other
reference allele: G
site quality: BaseQRankSum
site quality: FS
site quality: DP
site quality: InbreedingCoeff
site quality: QD
site quality: MQ
site quality: ReadPosRankSum
site quality: ClippingRankSum
site quality: VQSLOD
site quality: MQRankSum

22-22892303-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892303
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892303
    reference: chr 22
allele count: 89
allele frequency: 7.334520042194093e-4
allele num: 121344
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.798C>T
  hgvsp: ENST00000405655.3:c.798C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.750C>T
  hgvsp: ENST00000539862.1:c.750C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.798C>T
  hgvsp: ENST00000402697.1:c.798C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.798C>T
  hgvsp: ENST00000398741.1:c.798C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.798C>T
  hgvsp: ENST00000398743.2:c.798C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.798C>T
  hgvsp: ENST00000543184.1:c.798C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1733C>T
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.750C>T
  hgvsp: ENST00000424204.2:c.750C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 53
  bin: 7.75e1
  variant carriers: 6
genotype depth: GenotypeDepth
  all individuals: 361
  bin: 5.25e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 38
  bin: 8.25e1
  variant carriers: 10
genotype depth: GenotypeDepth
  all individuals: 8989
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 9.25e1
  variant carriers: 7
genotype depth: GenotypeDepth
  all individuals: 37
  bin: 8.75e1
  variant carriers: 6
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17352
  bin: 2.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 103
  bin: 9.75e1
  variant carriers: 34
genotype depth: GenotypeDepth
  all individuals: 73
  bin: 7.25e1
  variant carriers: 6
genotype depth: GenotypeDepth
  all individuals: 118
  bin: 6.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 27935
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 216
  bin: 5.75e1
  variant carriers: 4
genotype depth: GenotypeDepth
  all individuals: 3142
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1381
  bin: 4.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 700
  bin: 4.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 109
  bin: 6.75e1
  variant carriers: 8
genotype quality: GenotypeQuality
  all individuals: 30571
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1954
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3616
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5003
  bin: 9.75e1
  variant carriers: 89
genotype quality: GenotypeQuality
  all individuals: 5160
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9
  bin: 4.75e1
  variant carriers: 0
hgvs: p.Leu266Leu
num of homozygotes: 0
population: European (Non-Finnish)
population: Other
population: African
population: East Asian
population: Latino
population: European (Finnish)
population: South Asian
reference allele: G
site quality: ReadPosRankSum
site quality: QD
site quality: BaseQRankSum
site quality: InbreedingCoeff
site quality: MQ
site quality: MQRankSum
site quality: DP
site quality: VQSLOD
site quality: FS
site quality: ClippingRankSum

22-22892306-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892306
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892306
    reference: chr 22
allele count: 35
allele frequency: 2.884409355375715e-4
allele num: 121342
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.795C>T
  hgvsp: ENST00000398743.2:c.795C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.747C>T
  hgvsp: ENST00000539862.1:c.747C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.795C>T
  hgvsp: ENST00000405655.3:c.795C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.795C>T
  hgvsp: ENST00000402697.1:c.795C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.747C>T
  hgvsp: ENST00000424204.2:c.747C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.795C>T
  hgvsp: ENST00000543184.1:c.795C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.795C>T
  hgvsp: ENST00000398741.1:c.795C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1730C>T
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 1384
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3153
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8983
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 123
  bin: 6.25e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 24
  bin: 9.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 86
  bin: 9.75e1
  variant carriers: 14
genotype depth: GenotypeDepth
  all individuals: 375
  bin: 5.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 53
  bin: 7.75e1
  variant carriers: 4
genotype depth: GenotypeDepth
  all individuals: 27933
  bin: 2.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 40
  bin: 8.75e1
  variant carriers: 7
genotype depth: GenotypeDepth
  all individuals: 706
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 104
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17350
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 217
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 8.25e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 69
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 30579
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 1.25e1
  variant carriers: 0
hgvs: p.Leu265Leu
num of homozygotes: 0
population: African
population: Latino
population: Other
population: European (Non-Finnish)
population: East Asian
population: European (Finnish)
population: South Asian
reference allele: G
site quality: ReadPosRankSum
site quality: QD
site quality: DP
site quality: FS
site quality: MQRankSum
site quality: MQ
site quality: BaseQRankSum
site quality: VQSLOD
site quality: ClippingRankSum
site quality: InbreedingCoeff

22-22892306-G-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892306
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892306
    reference: chr 22
allele count: 4
allele frequency: 3.296467834715103e-5
allele num: 121342
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.795C>A
  hgvsp: ENST00000398741.1:c.795C>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.795C>A
  hgvsp: ENST00000543184.1:c.795C>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.747C>A
  hgvsp: ENST00000424204.2:c.747C>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.795C>A
  hgvsp: ENST00000398743.2:c.795C>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1730C>A
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.747C>A
  hgvsp: ENST00000539862.1:c.747C>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.795C>A
  hgvsp: ENST00000405655.3:c.795C>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.795C>A
  hgvsp: ENST00000402697.1:c.795C>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1384
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 217
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 40
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 53
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 24
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 8.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 104
  bin: 6.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 27933
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8983
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 706
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 375
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 69
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 86
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 17350
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3153
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 123
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5001
  bin: 9.75e1
  variant carriers: 4
genotype quality: GenotypeQuality
  all individuals: 30579
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4028
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1954
  bin: 9.25e1
  variant carriers: 0
hgvs: p.Leu265Leu
num of homozygotes: 0
population: European (Non-Finnish)
population: European (Finnish)
population: Other
population: African
population: South Asian
population: Latino
population: East Asian
reference allele: G
site quality: ClippingRankSum
site quality: FS
site quality: BaseQRankSum
site quality: ReadPosRankSum
site quality: InbreedingCoeff
site quality: VQSLOD
site quality: MQRankSum
site quality: MQ
site quality: DP
site quality: QD

http://identifiers.org/exac.variant/22-22892307-A-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892307
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892307
    reference: chr 22
allele count: 4
allele frequency: 3.296467834715103e-5
allele num: 121342
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.794T>G
  hgvsp: ENSP00000381728.2:p.Leu265Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1729T>G
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.794T>G
  hgvsp: ENSP00000385198.1:p.Leu265Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.794T>G
  hgvsp: ENSP00000384343.3:p.Leu265Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.746T>G
  hgvsp: ENSP00000445097.1:p.Leu249Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.794T>G
  hgvsp: ENSP00000381726.1:p.Leu265Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.794T>G
  hgvsp: ENSP00000445675.1:p.Leu265Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.746T>G
  hgvsp: ENSP00000407342.2:p.Leu249Arg
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 3157
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 70
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 712
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1387
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 24
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17352
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27932
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 76
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 217
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 123
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 377
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 50
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 106
  bin: 6.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 8987
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 8.25e1
  variant carriers: 2
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8570
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4027
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1955
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 23
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 3.75e1
  variant carriers: 0
hgvs: p.Leu265Arg
num of homozygotes: 0
population: East Asian
population: African
population: South Asian
population: European (Non-Finnish)
population: European (Finnish)
population: Other
population: Latino
reference allele: A
site quality: VQSLOD
site quality: ReadPosRankSum
site quality: MQRankSum
site quality: MQ
site quality: InbreedingCoeff
site quality: ClippingRankSum
site quality: BaseQRankSum
site quality: FS
site quality: DP
site quality: QD

22-22892307-A-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892307
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892307
    reference: chr 22
allele count: 1
allele frequency: 8.241169586787756e-6
allele num: 121342
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.794T>C
  hgvsp: ENSP00000381728.2:p.Leu265Pro
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.794T>C
  hgvsp: ENSP00000385198.1:p.Leu265Pro
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1729T>C
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.794T>C
  hgvsp: ENSP00000381726.1:p.Leu265Pro
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.746T>C
  hgvsp: ENSP00000445097.1:p.Leu249Pro
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.794T>C
  hgvsp: ENSP00000445675.1:p.Leu265Pro
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.746T>C
  hgvsp: ENSP00000407342.2:p.Leu249Pro
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.794T>C
  hgvsp: ENSP00000384343.3:p.Leu265Pro
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1387
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8987
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3157
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 24
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 712
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 106
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 377
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 123
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 76
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 50
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17352
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27932
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 217
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 8.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 70
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1955
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 30582
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 23
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5
  bin: 2.75e1
  variant carriers: 0
hgvs: p.Leu265Pro
num of homozygotes: 0
population: European (Non-Finnish)
population: Latino
population: Other
population: South Asian
population: East Asian
population: African
population: European (Finnish)
reference allele: A
site quality: ClippingRankSum
site quality: BaseQRankSum
site quality: InbreedingCoeff
site quality: FS
site quality: MQ
site quality: MQRankSum
site quality: ReadPosRankSum
site quality: QD
site quality: DP
site quality: VQSLOD

22-22892308-G-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892308
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892308
    reference: chr 22
allele count: 10
allele frequency: 8.241169586787757e-5
allele num: 121342
alternate allele: C
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.793C>G
  hgvsp: ENSP00000445675.1:p.Leu265Val
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.793C>G
  hgvsp: ENSP00000384343.3:p.Leu265Val
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.745C>G
  hgvsp: ENSP00000445097.1:p.Leu249Val
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.793C>G
  hgvsp: ENSP00000381728.2:p.Leu265Val
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.793C>G
  hgvsp: ENSP00000385198.1:p.Leu265Val
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.745C>G
  hgvsp: ENSP00000407342.2:p.Leu249Val
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1728C>G
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.793C>G
  hgvsp: ENSP00000381726.1:p.Leu265Val
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 105
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 712
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 70
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27930
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17350
  bin: 2.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 379
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1388
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 8.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 81
  bin: 9.75e1
  variant carriers: 5
genotype depth: GenotypeDepth
  all individuals: 52
  bin: 7.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 8985
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 30
  bin: 8.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 217
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3156
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 123
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 11
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 15
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 1.25e1
  variant carriers: 0
hgvs: p.Leu265Val
num of homozygotes: 0
population: East Asian
population: European (Finnish)
population: European (Non-Finnish)
population: South Asian
population: Latino
population: African
population: Other
reference allele: G
site quality: MQ
site quality: DP
site quality: BaseQRankSum
site quality: QD
site quality: VQSLOD
site quality: ReadPosRankSum
site quality: MQRankSum
site quality: FS
site quality: InbreedingCoeff
site quality: ClippingRankSum

22-22892313-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892313
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892313
    reference: chr 22
allele count: 6
allele frequency: 4.94486475794887e-5
allele num: 121338
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.788G>A
  hgvsp: ENSP00000385198.1:p.Arg263His
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.788G>A
  hgvsp: ENSP00000384343.3:p.Arg263His
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.788G>A
  hgvsp: ENSP00000445675.1:p.Arg263His
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.740G>A
  hgvsp: ENSP00000407342.2:p.Arg247His
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.788G>A
  hgvsp: ENSP00000381728.2:p.Arg263His
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.740G>A
  hgvsp: ENSP00000445097.1:p.Arg247His
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.788G>A
  hgvsp: ENSP00000381726.1:p.Arg263His
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1723G>A
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 382
  bin: 5.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 70
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 715
  bin: 4.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 124
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1388
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 217
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27932
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8986
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 79
  bin: 9.75e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 17344
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 30
  bin: 8.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3158
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 108
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 33
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 50
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3614
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 7
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4027
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 24
  bin: 2.25e1
  variant carriers: 0
hgvs: p.Arg263His
num of homozygotes: 0
population: South Asian
population: European (Finnish)
population: Other
population: European (Non-Finnish)
population: African
population: Latino
population: East Asian
reference allele: C
site quality: InbreedingCoeff
site quality: FS
site quality: VQSLOD
site quality: BaseQRankSum
site quality: QD
site quality: MQ
site quality: ClippingRankSum
site quality: MQRankSum
site quality: DP
site quality: ReadPosRankSum

22-22892314-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892314
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892314
    reference: chr 22
allele count: 264
allele frequency: 2.175740493497503e-3
allele num: 121338
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.787C>T
  hgvsp: ENSP00000385198.1:p.Arg263Cys
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.787C>T
  hgvsp: ENSP00000384343.3:p.Arg263Cys
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.787C>T
  hgvsp: ENSP00000381728.2:p.Arg263Cys
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.739C>T
  hgvsp: ENSP00000407342.2:p.Arg247Cys
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.739C>T
  hgvsp: ENSP00000445097.1:p.Arg247Cys
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.787C>T
  hgvsp: ENSP00000381726.1:p.Arg263Cys
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1722C>T
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.787C>T
  hgvsp: ENSP00000445675.1:p.Arg263Cys
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3138
  bin: 3.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 57
  bin: 8.75e1
  variant carriers: 23
genotype depth: GenotypeDepth
  all individuals: 116
  bin: 6.75e1
  variant carriers: 8
genotype depth: GenotypeDepth
  all individuals: 27810
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 36
  bin: 9.25e1
  variant carriers: 14
genotype depth: GenotypeDepth
  all individuals: 17281
  bin: 2.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 710
  bin: 4.75e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 134
  bin: 6.25e1
  variant carriers: 11
genotype depth: GenotypeDepth
  all individuals: 392
  bin: 5.25e1
  variant carriers: 11
genotype depth: GenotypeDepth
  all individuals: 44
  bin: 8.25e1
  variant carriers: 14
genotype depth: GenotypeDepth
  all individuals: 8944
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 228
  bin: 5.75e1
  variant carriers: 9
genotype depth: GenotypeDepth
  all individuals: 67
  bin: 7.75e1
  variant carriers: 19
genotype depth: GenotypeDepth
  all individuals: 86
  bin: 7.25e1
  variant carriers: 16
genotype depth: GenotypeDepth
  all individuals: 209
  bin: 9.75e1
  variant carriers: 133
genotype depth: GenotypeDepth
  all individuals: 1385
  bin: 4.25e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 6
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9
  bin: 5.75e1
  variant carriers: 0
hgvs: p.Arg263Cys
num of homozygotes: 0
population: European (Finnish)
population: Other
population: South Asian
population: European (Non-Finnish)
population: East Asian
population: African
population: Latino
reference allele: G
site quality: FS
site quality: MQ
site quality: QD
site quality: DP
site quality: ClippingRankSum
site quality: VQSLOD
site quality: InbreedingCoeff
site quality: BaseQRankSum
site quality: MQRankSum
site quality: ReadPosRankSum

22-22892314-G-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892314
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892314
    reference: chr 22
allele count: 1
allele frequency: 8.241441263248117e-6
allele num: 121338
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.739C>G
  hgvsp: ENSP00000445097.1:p.Arg247Gly
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.787C>G
  hgvsp: ENSP00000385198.1:p.Arg263Gly
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.787C>G
  hgvsp: ENSP00000445675.1:p.Arg263Gly
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.787C>G
  hgvsp: ENSP00000384343.3:p.Arg263Gly
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1722C>G
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.787C>G
  hgvsp: ENSP00000381728.2:p.Arg263Gly
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.787C>G
  hgvsp: ENSP00000381726.1:p.Arg263Gly
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.739C>G
  hgvsp: ENSP00000407342.2:p.Arg247Gly
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 134
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 57
  bin: 8.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 86
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1385
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27810
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17281
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3138
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 228
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 209
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 710
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 67
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8944
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 36
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 116
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 392
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 44
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5232
  bin: 9.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8525
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 12
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4011
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 23
  bin: 2.25e1
  variant carriers: 0
hgvs: p.Arg263Gly
num of homozygotes: 0
population: European (Non-Finnish)
population: South Asian
population: Latino
population: European (Finnish)
population: Other
population: African
population: East Asian
reference allele: G
site quality: QD
site quality: InbreedingCoeff
site quality: MQRankSum
site quality: BaseQRankSum
site quality: FS
site quality: ReadPosRankSum
site quality: MQ
site quality: ClippingRankSum
site quality: VQSLOD
site quality: DP

22-22892319-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892319
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892319
    reference: chr 22
allele count: 1
allele frequency: 8.241305422778968e-6
allele num: 121340
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.782A>G
  hgvsp: ENSP00000381726.1:p.Asn261Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.734A>G
  hgvsp: ENSP00000407342.2:p.Asn245Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.782A>G
  hgvsp: ENSP00000384343.3:p.Asn261Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.782A>G
  hgvsp: ENSP00000445675.1:p.Asn261Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.734A>G
  hgvsp: ENSP00000445097.1:p.Asn245Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.782A>G
  hgvsp: ENSP00000385198.1:p.Asn261Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.782A>G
  hgvsp: ENSP00000381728.2:p.Asn261Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1717A>G
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 249
  bin: 5.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 24
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1404
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3155
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17299
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 77
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27812
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 741
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 409
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8968
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 138
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 87
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 57
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 40
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 133
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 36
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4021
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 30489
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 4.25e1
  variant carriers: 0
hgvs: p.Asn261Ser
num of homozygotes: 0
population: European (Finnish)
population: Other
population: African
population: South Asian
population: European (Non-Finnish)
population: East Asian
population: Latino
reference allele: T
site quality: DP
site quality: FS
site quality: MQRankSum
site quality: BaseQRankSum
site quality: VQSLOD
site quality: InbreedingCoeff
site quality: QD
site quality: ClippingRankSum
site quality: MQ
site quality: ReadPosRankSum

http://identifiers.org/exac.variant/22-22892321-A-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892321
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892321
    reference: chr 22
allele count: 1
allele frequency: 8.241305422778968e-6
allele num: 121340
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.732T>G
  hgvsp: ENSP00000407342.2:p.Ile244Met
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1715T>G
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.780T>G
  hgvsp: ENSP00000385198.1:p.Ile260Met
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.780T>G
  hgvsp: ENSP00000381728.2:p.Ile260Met
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.780T>G
  hgvsp: ENSP00000384343.3:p.Ile260Met
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.780T>G
  hgvsp: ENSP00000445675.1:p.Ile260Met
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.780T>G
  hgvsp: ENSP00000381726.1:p.Ile260Met
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.732T>G
  hgvsp: ENSP00000445097.1:p.Ile244Met
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 57
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 36
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 741
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 88
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 26
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 77
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1405
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 409
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 40
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 138
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 248
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27808
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8970
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3155
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 133
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17298
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 11
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 30489
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1958
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5
  bin: 2.75e1
  variant carriers: 0
hgvs: p.Ile260Met
num of homozygotes: 0
population: European (Finnish)
population: African
population: Other
population: East Asian
population: Latino
population: South Asian
population: European (Non-Finnish)
reference allele: A
site quality: VQSLOD
site quality: MQ
site quality: ReadPosRankSum
site quality: QD
site quality: ClippingRankSum
site quality: MQRankSum
site quality: BaseQRankSum
site quality: FS
site quality: InbreedingCoeff
site quality: DP

22-22892324-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892324
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892324
    reference: chr 22
allele count: 1
allele frequency: 8.241577108195424e-6
allele num: 121336
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.777G>A
  hgvsp: ENSP00000385198.1:p.Met259Ile
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.777G>A
  hgvsp: ENSP00000381728.2:p.Met259Ile
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.777G>A
  hgvsp: ENSP00000384343.3:p.Met259Ile
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.729G>A
  hgvsp: ENSP00000445097.1:p.Met243Ile
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1712G>A
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.777G>A
  hgvsp: ENSP00000381726.1:p.Met259Ile
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.777G>A
  hgvsp: ENSP00000445675.1:p.Met259Ile
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.729G>A
  hgvsp: ENSP00000407342.2:p.Met243Ile
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: VQSRTrancheSNP99.60to99.80
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 138
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 88
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 409
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 77
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8970
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27802
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 744
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17298
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1406
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 248
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3154
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 133
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 36
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 40
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 57
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 14
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8541
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5135
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1706
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 30477
  bin: 6.25e1
  variant carriers: 0
hgvs: p.Met259Ile
num of homozygotes: 0
population: European (Non-Finnish)
population: East Asian
population: South Asian
population: African
population: Other
population: European (Finnish)
population: Latino
reference allele: C
site quality: MQ
site quality: BaseQRankSum
site quality: FS
site quality: VQSLOD
site quality: ClippingRankSum
site quality: ReadPosRankSum
site quality: DP
site quality: InbreedingCoeff
site quality: MQRankSum
site quality: QD

22-22892326-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892326
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892326
    reference: chr 22
allele count: 9
allele frequency: 7.417052628108981e-5
allele num: 121342
alternate allele: C
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.775A>G
  hgvsp: ENSP00000445675.1:p.Met259Val
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.775A>G
  hgvsp: ENSP00000381728.2:p.Met259Val
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.727A>G
  hgvsp: ENSP00000407342.2:p.Met243Val
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.775A>G
  hgvsp: ENSP00000381726.1:p.Met259Val
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.727A>G
  hgvsp: ENSP00000445097.1:p.Met243Val
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.775A>G
  hgvsp: ENSP00000385198.1:p.Met259Val
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1710A>G
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.775A>G
  hgvsp: ENSP00000384343.3:p.Met259Val
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 409
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 742
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 139
  bin: 6.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17297
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 36
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 90
  bin: 9.75e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 133
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 249
  bin: 5.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1404
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27796
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3154
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8972
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 78
  bin: 7.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 26
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 60
  bin: 7.75e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 41
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 25
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1958
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 11
  bin: 4.75e1
  variant carriers: 0
hgvs: p.Met259Val
num of homozygotes: 0
population: Other
population: African
population: European (Non-Finnish)
population: Latino
population: East Asian
population: European (Finnish)
population: South Asian
reference allele: T
site quality: QD
site quality: FS
site quality: MQRankSum
site quality: DP
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: MQ
site quality: ReadPosRankSum
site quality: InbreedingCoeff
site quality: VQSLOD

22-22892328-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892328
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892328
    reference: chr 22
allele count: 2
allele frequency: 1.648261084555794e-5
allele num: 121340
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1708A>G
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.725A>G
  hgvsp: ENSP00000445097.1:p.Gln242Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.773A>G
  hgvsp: ENSP00000385198.1:p.Gln258Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.773A>G
  hgvsp: ENSP00000381726.1:p.Gln258Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.773A>G
  hgvsp: ENSP00000381728.2:p.Gln258Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.773A>G
  hgvsp: ENSP00000384343.3:p.Gln258Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.725A>G
  hgvsp: ENSP00000407342.2:p.Gln242Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.773A>G
  hgvsp: ENSP00000445675.1:p.Gln258Arg
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 138
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1404
  bin: 4.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 57
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 88
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 27793
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 250
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 744
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8973
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 409
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17296
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 79
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 41
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 30
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 133
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3156
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 36
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1961
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 25
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8544
  bin: 6.75e1
  variant carriers: 0
hgvs: p.Gln258Arg
num of homozygotes: 0
population: European (Finnish)
population: South Asian
population: Latino
population: Other
population: African
population: East Asian
population: European (Non-Finnish)
reference allele: T
site quality: MQRankSum
site quality: BaseQRankSum
site quality: DP
site quality: ReadPosRankSum
site quality: InbreedingCoeff
site quality: ClippingRankSum
site quality: QD
site quality: VQSLOD
site quality: FS
site quality: MQ

22-22892331-C-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892331
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892331
    reference: chr 22
allele count: 2
allele frequency: 1.648261084555794e-5
allele num: 121340
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.770G>C
  hgvsp: ENSP00000384343.3:p.Gly257Ala
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.722G>C
  hgvsp: ENSP00000407342.2:p.Gly241Ala
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.770G>C
  hgvsp: ENSP00000381726.1:p.Gly257Ala
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.770G>C
  hgvsp: ENSP00000381728.2:p.Gly257Ala
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.770G>C
  hgvsp: ENSP00000385198.1:p.Gly257Ala
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1705G>C
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.770G>C
  hgvsp: ENSP00000445675.1:p.Gly257Ala
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.722G>C
  hgvsp: ENSP00000445097.1:p.Gly241Ala
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 3157
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 745
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 411
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 138
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8972
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17300
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 57
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 41
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 36
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27777
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 250
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 88
  bin: 9.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 33
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 133
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 79
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1406
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 7
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1707
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 20
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1959
  bin: 9.25e1
  variant carriers: 0
hgvs: p.Gly257Ala
num of homozygotes: 0
population: Latino
population: European (Finnish)
population: Other
population: African
population: East Asian
population: European (Non-Finnish)
population: South Asian
reference allele: C
site quality: MQRankSum
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: QD
site quality: ReadPosRankSum
site quality: InbreedingCoeff
site quality: DP
site quality: VQSLOD
site quality: FS
site quality: MQ

22-22892335-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892335
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892335
    reference: chr 22
allele count: 572
allele frequency: 4.714104402577923e-3
allele num: 121338
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1701C>T
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.718C>T
  hgvsp: ENST00000539862.1:c.718C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.766C>T
  hgvsp: ENST00000402697.1:c.766C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.718C>T
  hgvsp: ENST00000424204.2:c.718C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.766C>T
  hgvsp: ENST00000405655.3:c.766C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.766C>T
  hgvsp: ENST00000398741.1:c.766C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.766C>T
  hgvsp: ENST00000543184.1:c.766C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.766C>T
  hgvsp: ENST00000398743.2:c.766C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 176
  bin: 6.25e1
  variant carriers: 40
genotype depth: GenotypeDepth
  all individuals: 1399
  bin: 4.25e1
  variant carriers: 12
genotype depth: GenotypeDepth
  all individuals: 91
  bin: 7.75e1
  variant carriers: 38
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27532
  bin: 2.25e1
  variant carriers: 4
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17169
  bin: 2.75e1
  variant carriers: 4
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 762
  bin: 4.75e1
  variant carriers: 28
genotype depth: GenotypeDepth
  all individuals: 3132
  bin: 3.75e1
  variant carriers: 7
genotype depth: GenotypeDepth
  all individuals: 113
  bin: 7.25e1
  variant carriers: 37
genotype depth: GenotypeDepth
  all individuals: 168
  bin: 6.75e1
  variant carriers: 37
genotype depth: GenotypeDepth
  all individuals: 59
  bin: 9.25e1
  variant carriers: 34
genotype depth: GenotypeDepth
  all individuals: 8891
  bin: 3.25e1
  variant carriers: 4
genotype depth: GenotypeDepth
  all individuals: 270
  bin: 9.75e1
  variant carriers: 186
genotype depth: GenotypeDepth
  all individuals: 437
  bin: 5.25e1
  variant carriers: 34
genotype depth: GenotypeDepth
  all individuals: 285
  bin: 5.75e1
  variant carriers: 40
genotype depth: GenotypeDepth
  all individuals: 64
  bin: 8.75e1
  variant carriers: 28
genotype depth: GenotypeDepth
  all individuals: 67
  bin: 8.25e1
  variant carriers: 28
genotype quality: GenotypeQuality
  all individuals: 1693
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 11
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 30214
  bin: 6.25e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 17
  bin: 4.75e1
  variant carriers: 0
hgvs: p.Leu256Leu
num of homozygotes: 11
population: European (Finnish)
population: European (Non-Finnish)
population: Other
population: African
population: Latino
population: East Asian
population: South Asian
reference allele: G
site quality: InbreedingCoeff
site quality: MQRankSum
site quality: MQ
site quality: ClippingRankSum
site quality: ReadPosRankSum
site quality: QD
site quality: VQSLOD
site quality: DP
site quality: BaseQRankSum
site quality: FS

22-22892338-AAGG-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892338
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892335
    reference: chr 22
allele count: 3
allele frequency: 2.472432378974435e-5
allele num: 121338
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: inframe_deletion
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.712_714delCCT
  hgvsp: ENSP00000445097.1:p.Pro238del
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: inframe_deletion
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.760_762delCCT
  hgvsp: ENSP00000381728.2:p.Pro254del
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: inframe_deletion
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.760_762delCCT
  hgvsp: ENSP00000384343.3:p.Pro254del
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: inframe_deletion
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.760_762delCCT
  hgvsp: ENSP00000385198.1:p.Pro254del
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: inframe_deletion
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.760_762delCCT
  hgvsp: ENSP00000445675.1:p.Pro254del
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1695_1697delCCT
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: inframe_deletion
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.760_762delCCT
  hgvsp: ENSP00000381726.1:p.Pro254del
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: inframe_deletion
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.712_714delCCT
  hgvsp: ENSP00000407342.2:p.Pro238del
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: inframe deletion
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 17236
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 25
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27540
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1443
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 96
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 72
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3179
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 149
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 35
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 798
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 48
  bin: 8.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 101
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 8.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 172
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 453
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 291
  bin: 5.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 8956
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8495
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 30289
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 14
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 17
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 10
  bin: 7.5e0
  variant carriers: 0
hgvs: p.Pro254del
num of homozygotes: 0
population: European (Finnish)
population: Latino
population: European (Non-Finnish)
population: Other
population: African
population: East Asian
population: South Asian
reference allele: AAGG
site quality: FS
site quality: InbreedingCoeff
site quality: MQRankSum
site quality: MQ
site quality: ReadPosRankSum
site quality: DP
site quality: ClippingRankSum
site quality: BaseQRankSum
site quality: VQSLOD
site quality: QD

22-22892341-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892341
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892341
    reference: chr 22
allele count: 3
allele frequency: 2.472473132458627e-5
allele num: 121336
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.760C>T
  hgvsp: ENSP00000381728.2:p.Pro254Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.760C>T
  hgvsp: ENSP00000385198.1:p.Pro254Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.712C>T
  hgvsp: ENSP00000407342.2:p.Pro238Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.760C>T
  hgvsp: ENSP00000445675.1:p.Pro254Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.760C>T
  hgvsp: ENSP00000381726.1:p.Pro254Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.760C>T
  hgvsp: ENSP00000384343.3:p.Pro254Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.712C>T
  hgvsp: ENSP00000445097.1:p.Pro238Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1695C>T
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 172
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 150
  bin: 6.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 1443
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 8.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 452
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17237
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 797
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8960
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27528
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 38
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3181
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 101
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 48
  bin: 8.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 96
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 291
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 72
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 30284
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 12
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 19
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5099
  bin: 7.75e1
  variant carriers: 0
hgvs: p.Pro254Ser
num of homozygotes: 0
population: Latino
population: European (Non-Finnish)
population: Other
population: South Asian
population: African
population: European (Finnish)
population: East Asian
reference allele: G
site quality: MQ
site quality: VQSLOD
site quality: QD
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: DP
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: FS
site quality: ReadPosRankSum

22-22892342-A-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892342
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892342
    reference: chr 22
allele count: 1489
allele frequency: 1.227211288036132e-2
allele num: 121332
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.759T>C
  hgvsp: ENST00000398741.1:c.759T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.759T>C
  hgvsp: ENST00000402697.1:c.759T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1694T>C
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.759T>C
  hgvsp: ENST00000398743.2:c.759T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.759T>C
  hgvsp: ENST00000405655.3:c.759T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.711T>C
  hgvsp: ENST00000539862.1:c.711T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.711T>C
  hgvsp: ENST00000424204.2:c.711T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.759T>C
  hgvsp: ENST00000543184.1:c.759T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 16859
  bin: 2.75e1
  variant carriers: 8
genotype depth: GenotypeDepth
  all individuals: 377
  bin: 9.75e1
  variant carriers: 282
genotype depth: GenotypeDepth
  all individuals: 239
  bin: 7.25e1
  variant carriers: 146
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 7.5e0
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 292
  bin: 6.25e1
  variant carriers: 126
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 2.5e0
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 194
  bin: 7.75e1
  variant carriers: 126
genotype depth: GenotypeDepth
  all individuals: 3128
  bin: 3.75e1
  variant carriers: 27
genotype depth: GenotypeDepth
  all individuals: 402
  bin: 5.75e1
  variant carriers: 117
genotype depth: GenotypeDepth
  all individuals: 38
  bin: 1.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 286
  bin: 6.75e1
  variant carriers: 140
genotype depth: GenotypeDepth
  all individuals: 520
  bin: 5.25e1
  variant carriers: 81
genotype depth: GenotypeDepth
  all individuals: 8746
  bin: 3.25e1
  variant carriers: 8
genotype depth: GenotypeDepth
  all individuals: 152
  bin: 8.25e1
  variant carriers: 105
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 137
  bin: 8.75e1
  variant carriers: 97
genotype depth: GenotypeDepth
  all individuals: 114
  bin: 9.25e1
  variant carriers: 81
genotype depth: GenotypeDepth
  all individuals: 26846
  bin: 2.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 1449
  bin: 4.25e1
  variant carriers: 47
genotype depth: GenotypeDepth
  all individuals: 865
  bin: 4.75e1
  variant carriers: 79
genotype quality: GenotypeQuality
  all individuals: 15
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 21
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 7
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 13
  bin: 2.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 24
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 1.75e1
  variant carriers: 0
hgvs: p.Ser253Ser
num of homozygotes: 16
population: South Asian
population: African
population: European (Finnish)
population: European (Non-Finnish)
population: East Asian
population: Other
population: Latino
reference allele: A
site quality: ReadPosRankSum
site quality: VQSLOD
site quality: DP
site quality: MQ
site quality: MQRankSum
site quality: QD
site quality: FS
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: InbreedingCoeff

22-22892351-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892351
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892351
    reference: chr 22
allele count: 3
allele frequency: 2.472473132458627e-5
allele num: 121336
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1685G>A
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.750G>A
  hgvsp: ENST00000398743.2:c.750G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.702G>A
  hgvsp: ENST00000424204.2:c.702G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.702G>A
  hgvsp: ENST00000539862.1:c.702G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.750G>A
  hgvsp: ENST00000405655.3:c.750G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.750G>A
  hgvsp: ENST00000402697.1:c.750G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.750G>A
  hgvsp: ENST00000398741.1:c.750G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.750G>A
  hgvsp: ENST00000543184.1:c.750G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 1561
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3253
  bin: 3.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 96
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 206
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 9.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 69
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26881
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8873
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 939
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 599
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 274
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 402
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 136
  bin: 7.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 57
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 141
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17071
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1988
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1707
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8383
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 13
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 24
  bin: 2.25e1
  variant carriers: 0
hgvs: p.Ala250Ala
num of homozygotes: 0
population: African
population: East Asian
population: European (Finnish)
population: European (Non-Finnish)
population: South Asian
population: Other
population: Latino
reference allele: C
site quality: FS
site quality: QD
site quality: ClippingRankSum
site quality: ReadPosRankSum
site quality: BaseQRankSum
site quality: InbreedingCoeff
site quality: DP
site quality: MQ
site quality: VQSLOD
site quality: MQRankSum

22-22892352-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892352
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892352
    reference: chr 22
allele count: 23
allele frequency: 1.895531490547067e-4
allele num: 121338
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.749C>T
  hgvsp: ENSP00000384343.3:p.Ala250Val
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.749C>T
  hgvsp: ENSP00000445675.1:p.Ala250Val
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.701C>T
  hgvsp: ENSP00000407342.2:p.Ala234Val
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.749C>T
  hgvsp: ENSP00000381728.2:p.Ala250Val
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.749C>T
  hgvsp: ENSP00000385198.1:p.Ala250Val
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1684C>T
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.701C>T
  hgvsp: ENSP00000445097.1:p.Ala234Val
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.749C>T
  hgvsp: ENSP00000381726.1:p.Ala250Val
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 9.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8868
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 275
  bin: 6.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 938
  bin: 4.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 209
  bin: 6.75e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 146
  bin: 9.75e1
  variant carriers: 5
genotype depth: GenotypeDepth
  all individuals: 99
  bin: 7.75e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 3253
  bin: 3.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 601
  bin: 5.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 70
  bin: 8.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 48
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1562
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26860
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17071
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 58
  bin: 8.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 405
  bin: 5.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 138
  bin: 7.25e1
  variant carriers: 3
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 29765
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 22
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 15
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3557
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 20
  bin: 3.25e1
  variant carriers: 0
hgvs: p.Ala250Val
num of homozygotes: 0
population: Other
population: European (Non-Finnish)
population: Latino
population: East Asian
population: European (Finnish)
population: African
population: South Asian
reference allele: G
site quality: MQ
site quality: VQSLOD
site quality: ReadPosRankSum
site quality: InbreedingCoeff
site quality: QD
site quality: FS
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: MQRankSum
site quality: DP

22-22892357-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892357
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892357
    reference: chr 22
allele count: 17
allele frequency: 1.401068108393222e-4
allele num: 121336
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.696C>T
  hgvsp: ENST00000539862.1:c.696C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1679C>T
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.744C>T
  hgvsp: ENST00000398743.2:c.744C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.744C>T
  hgvsp: ENST00000402697.1:c.744C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.744C>T
  hgvsp: ENST00000543184.1:c.744C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.744C>T
  hgvsp: ENST00000405655.3:c.744C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.744C>T
  hgvsp: ENST00000398741.1:c.744C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.696C>T
  hgvsp: ENST00000424204.2:c.696C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 25
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26851
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 135
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8861
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1568
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 941
  bin: 4.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 3258
  bin: 3.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 98
  bin: 7.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 277
  bin: 6.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 145
  bin: 9.75e1
  variant carriers: 4
genotype depth: GenotypeDepth
  all individuals: 210
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 602
  bin: 5.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 407
  bin: 5.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 17076
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 69
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 45
  bin: 9.25e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 60
  bin: 8.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 9
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 15
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 25
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1988
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 19
  bin: 3.25e1
  variant carriers: 0
hgvs: p.Thr248Thr
num of homozygotes: 0
population: East Asian
population: African
population: South Asian
population: Latino
population: Other
population: European (Finnish)
population: European (Non-Finnish)
reference allele: G
site quality: ClippingRankSum
site quality: MQ
site quality: VQSLOD
site quality: FS
site quality: DP
site quality: ReadPosRankSum
site quality: InbreedingCoeff
site quality: BaseQRankSum
site quality: MQRankSum
site quality: QD

22-22892362-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892362
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892362
    reference: chr 22
allele count: 25
allele frequency: 2.06046220288135e-4
allele num: 121332
alternate allele: A
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.739C>T
  hgvsp: ENSP00000445675.1:p.Pro247Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.739C>T
  hgvsp: ENSP00000385198.1:p.Pro247Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.691C>T
  hgvsp: ENSP00000407342.2:p.Pro231Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.739C>T
  hgvsp: ENSP00000384343.3:p.Pro247Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1674C>T
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.691C>T
  hgvsp: ENSP00000445097.1:p.Pro231Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.739C>T
  hgvsp: ENSP00000381726.1:p.Pro247Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.739C>T
  hgvsp: ENSP00000381728.2:p.Pro247Ser
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 97
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 277
  bin: 6.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 945
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 75
  bin: 8.25e1
  variant carriers: 6
genotype depth: GenotypeDepth
  all individuals: 606
  bin: 5.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 3253
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 63
  bin: 8.75e1
  variant carriers: 4
genotype depth: GenotypeDepth
  all individuals: 407
  bin: 5.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 24
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1575
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8871
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 46
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26826
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 138
  bin: 7.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 149
  bin: 9.75e1
  variant carriers: 7
genotype depth: GenotypeDepth
  all individuals: 17062
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 212
  bin: 6.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 16
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 20
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 16
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 18
  bin: 3.75e1
  variant carriers: 0
hgvs: p.Pro247Ser
num of homozygotes: 0
population: East Asian
population: Latino
population: Other
population: African
population: European (Finnish)
population: European (Non-Finnish)
population: South Asian
reference allele: G
site quality: FS
site quality: DP
site quality: BaseQRankSum
site quality: MQRankSum
site quality: VQSLOD
site quality: ClippingRankSum
site quality: ReadPosRankSum
site quality: MQ
site quality: InbreedingCoeff
site quality: QD

22-22892365-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892365
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892365
    reference: chr 22
allele count: 45
allele frequency: 3.7087708309295e-4
allele num: 121334
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.736C>T
  hgvsp: ENST00000398741.1:c.736C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.736C>T
  hgvsp: ENST00000402697.1:c.736C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.736C>T
  hgvsp: ENST00000543184.1:c.736C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.736C>T
  hgvsp: ENST00000398743.2:c.736C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.688C>T
  hgvsp: ENST00000424204.2:c.688C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.736C>T
  hgvsp: ENST00000405655.3:c.736C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1671C>T
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.688C>T
  hgvsp: ENST00000539862.1:c.688C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 70
  bin: 8.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 44
  bin: 9.25e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 138
  bin: 7.25e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 8870
  bin: 3.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 44
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 952
  bin: 4.75e1
  variant carriers: 5
genotype depth: GenotypeDepth
  all individuals: 274
  bin: 6.25e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 17069
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 217
  bin: 6.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 26821
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 407
  bin: 5.75e1
  variant carriers: 5
genotype depth: GenotypeDepth
  all individuals: 96
  bin: 7.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 609
  bin: 5.25e1
  variant carriers: 4
genotype depth: GenotypeDepth
  all individuals: 3257
  bin: 3.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 154
  bin: 9.75e1
  variant carriers: 12
genotype depth: GenotypeDepth
  all individuals: 1569
  bin: 4.25e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 18
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8384
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 18
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 27
  bin: 2.25e1
  variant carriers: 0
hgvs: p.Leu246Leu
num of homozygotes: 1
population: European (Non-Finnish)
population: Latino
population: Other
population: African
population: European (Finnish)
population: East Asian
population: South Asian
reference allele: G
site quality: ClippingRankSum
site quality: FS
site quality: DP
site quality: ReadPosRankSum
site quality: MQ
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: VQSLOD
site quality: QD
site quality: BaseQRankSum

22-22892372-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892372
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892372
    reference: chr 22
allele count: 1
allele frequency: 8.242120532770671e-6
allele num: 121328
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.729C>T
  hgvsp: ENST00000402697.1:c.729C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.681C>T
  hgvsp: ENST00000424204.2:c.681C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.729C>T
  hgvsp: ENST00000405655.3:c.729C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.681C>T
  hgvsp: ENST00000539862.1:c.681C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.729C>T
  hgvsp: ENST00000543184.1:c.729C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.729C>T
  hgvsp: ENST00000398743.2:c.729C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.729C>T
  hgvsp: ENST00000398741.1:c.729C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1664C>T
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17080
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26814
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 611
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 142
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1575
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 956
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 273
  bin: 6.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 8877
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 95
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3258
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 48
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 135
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 215
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 402
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 68
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8390
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 15
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6170
  bin: 9.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 26
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3567
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 29764
  bin: 6.25e1
  variant carriers: 0
hgvs: p.Thr243Thr
num of homozygotes: 0
population: Other
population: South Asian
population: European (Finnish)
population: Latino
population: East Asian
population: African
population: European (Non-Finnish)
reference allele: G
site quality: ReadPosRankSum
site quality: MQ
site quality: VQSLOD
site quality: MQRankSum
site quality: QD
site quality: DP
site quality: FS
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: InbreedingCoeff

http://identifiers.org/exac.variant/22-22892375-A-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892375
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892375
    reference: chr 22
allele count: 2
allele frequency: 1.64836976230508e-5
allele num: 121332
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.726T>G
  hgvsp: ENSP00000384343.3:p.Cys242Trp
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.726T>G
  hgvsp: ENSP00000385198.1:p.Cys242Trp
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.726T>G
  hgvsp: ENSP00000445675.1:p.Cys242Trp
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.678T>G
  hgvsp: ENSP00000407342.2:p.Cys226Trp
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1661T>G
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.726T>G
  hgvsp: ENSP00000381728.2:p.Cys242Trp
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.726T>G
  hgvsp: ENSP00000381726.1:p.Cys242Trp
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.678T>G
  hgvsp: ENSP00000445097.1:p.Cys226Trp
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 8880
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17084
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 955
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1573
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 68
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 612
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 135
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 48
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 402
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 217
  bin: 6.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3262
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 95
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 142
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 272
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26804
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3939
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 7
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1710
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 29753
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8393
  bin: 6.75e1
  variant carriers: 0
hgvs: p.Cys242Trp
num of homozygotes: 0
population: African
population: European (Finnish)
population: Other
population: Latino
population: European (Non-Finnish)
population: East Asian
population: South Asian
reference allele: A
site quality: ReadPosRankSum
site quality: MQ
site quality: InbreedingCoeff
site quality: BaseQRankSum
site quality: QD
site quality: VQSLOD
site quality: FS
site quality: ClippingRankSum
site quality: MQRankSum
site quality: DP

22-22892379-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892379
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892379
    reference: chr 22
allele count: 1
allele frequency: 8.242392271933006e-6
allele num: 121324
alternate allele: A
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.722C>T
  hgvsp: ENSP00000445675.1:p.Thr241Ile
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.674C>T
  hgvsp: ENSP00000407342.2:p.Thr225Ile
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.722C>T
  hgvsp: ENSP00000384343.3:p.Thr241Ile
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.722C>T
  hgvsp: ENSP00000381728.2:p.Thr241Ile
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.722C>T
  hgvsp: ENSP00000381726.1:p.Thr241Ile
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1657C>T
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.674C>T
  hgvsp: ENSP00000445097.1:p.Thr225Ile
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.722C>T
  hgvsp: ENSP00000385198.1:p.Thr241Ile
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 49
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1576
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 273
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3263
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17090
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 68
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 95
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 142
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8882
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 136
  bin: 7.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 402
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26792
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 216
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 611
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 954
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1994
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 13
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 18
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5022
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 19
  bin: 3.25e1
  variant carriers: 0
hgvs: p.Thr241Ile
num of homozygotes: 0
population: Latino
population: African
population: East Asian
population: European (Non-Finnish)
population: European (Finnish)
population: Other
population: South Asian
reference allele: G
site quality: InbreedingCoeff
site quality: VQSLOD
site quality: ClippingRankSum
site quality: ReadPosRankSum
site quality: FS
site quality: MQRankSum
site quality: QD
site quality: MQ
site quality: BaseQRankSum
site quality: DP

22-22892392-C-CT
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892392
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892393
    reference: chr 22
allele count: 2
allele frequency: 1.648451280022419e-5
allele num: 121326
alternate allele: CT
annotation: Annotation
  canonical: false
  consequence: frameshift_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.708dupA
  hgvsp: ENSP00000385198.1:p.Asp237ArgfsTer25
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: frameshift_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.660dupA
  hgvsp: ENSP00000407342.2:p.Asp221ArgfsTer25
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: frameshift_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.708dupA
  hgvsp: ENSP00000445675.1:p.Asp237ArgfsTer25
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: frameshift_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.708dupA
  hgvsp: ENSP00000381728.2:p.Asp237ArgfsTer25
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1643dupA
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: frameshift_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.708dupA
  hgvsp: ENSP00000384343.3:p.Asp237ArgfsTer25
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: frameshift_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.708dupA
  hgvsp: ENSP00000381726.1:p.Asp237ArgfsTer25
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: frameshift_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.660dupA
  hgvsp: ENSP00000445097.1:p.Asp221ArgfsTer25
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: frameshift
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 137
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 49
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 274
  bin: 6.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8892
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 95
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 958
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26766
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 219
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 402
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1573
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17095
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 142
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 68
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 611
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3270
  bin: 3.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 17
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 29728
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 12
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8394
  bin: 6.75e1
  variant carriers: 0
hgvs: p.Asp237ArgfsTer25
num of homozygotes: 0
population: East Asian
population: African
population: European (Finnish)
population: Other
population: Latino
population: South Asian
population: European (Non-Finnish)
reference allele: C
site quality: BaseQRankSum
site quality: FS
site quality: ClippingRankSum
site quality: QD
site quality: MQRankSum
site quality: VQSLOD
site quality: InbreedingCoeff
site quality: ReadPosRankSum
site quality: MQ
site quality: DP

22-22892392-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892392
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892392
    reference: chr 22
allele count: 1
allele frequency: 8.242256400112095e-6
allele num: 121326
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1644G>A
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.661G>A
  hgvsp: ENSP00000407342.2:p.Asp221Asn
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.709G>A
  hgvsp: ENSP00000384343.3:p.Asp237Asn
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.709G>A
  hgvsp: ENSP00000445675.1:p.Asp237Asn
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.709G>A
  hgvsp: ENSP00000381728.2:p.Asp237Asn
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.709G>A
  hgvsp: ENSP00000381726.1:p.Asp237Asn
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.661G>A
  hgvsp: ENSP00000445097.1:p.Asp221Asn
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.709G>A
  hgvsp: ENSP00000385198.1:p.Asp237Asn
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 402
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3270
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 49
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 274
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 68
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8892
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1573
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 958
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26766
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 95
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 611
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 219
  bin: 6.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17095
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 137
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 142
  bin: 9.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 29728
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5024
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 19
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 1.25e1
  variant carriers: 0
hgvs: p.Asp237Asn
num of homozygotes: 0
population: Latino
population: European (Non-Finnish)
population: European (Finnish)
population: African
population: Other
population: South Asian
population: East Asian
reference allele: C
site quality: ReadPosRankSum
site quality: DP
site quality: MQ
site quality: ClippingRankSum
site quality: BaseQRankSum
site quality: InbreedingCoeff
site quality: FS
site quality: VQSLOD
site quality: MQRankSum
site quality: QD

http://identifiers.org/exac.variant/22-22892397-A-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892397
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892397
    reference: chr 22
allele count: 4
allele frequency: 3.296848213108268e-5
allele num: 121328
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.656T>G
  hgvsp: ENSP00000445097.1:p.Ile219Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.704T>G
  hgvsp: ENSP00000381728.2:p.Ile235Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.704T>G
  hgvsp: ENSP00000384343.3:p.Ile235Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.704T>G
  hgvsp: ENSP00000445675.1:p.Ile235Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.704T>G
  hgvsp: ENSP00000385198.1:p.Ile235Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.704T>G
  hgvsp: ENSP00000381726.1:p.Ile235Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.656T>G
  hgvsp: ENSP00000407342.2:p.Ile219Ser
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1639T>G
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 48
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1571
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26743
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 958
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 274
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3272
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8893
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 403
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 613
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17113
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 217
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 98
  bin: 7.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 69
  bin: 8.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 137
  bin: 7.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 142
  bin: 9.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1999
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1712
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 15
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 29727
  bin: 6.25e1
  variant carriers: 0
hgvs: p.Ile235Ser
num of homozygotes: 0
population: African
population: Other
population: Latino
population: South Asian
population: East Asian
population: European (Non-Finnish)
population: European (Finnish)
reference allele: A
site quality: BaseQRankSum
site quality: MQ
site quality: FS
site quality: DP
site quality: MQRankSum
site quality: ClippingRankSum
site quality: VQSLOD
site quality: InbreedingCoeff
site quality: QD
site quality: ReadPosRankSum

22-22892397-A-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892397
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892397
    reference: chr 22
allele count: 1
allele frequency: 8.242120532770671e-6
allele num: 121328
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1639T>C
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.704T>C
  hgvsp: ENSP00000385198.1:p.Ile235Thr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.656T>C
  hgvsp: ENSP00000407342.2:p.Ile219Thr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.704T>C
  hgvsp: ENSP00000384343.3:p.Ile235Thr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.704T>C
  hgvsp: ENSP00000445675.1:p.Ile235Thr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.704T>C
  hgvsp: ENSP00000381728.2:p.Ile235Thr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.704T>C
  hgvsp: ENSP00000381726.1:p.Ile235Thr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.656T>C
  hgvsp: ENSP00000445097.1:p.Ile219Thr
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 98
  bin: 7.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 3272
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 403
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8893
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1571
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 69
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 48
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 274
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 958
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 613
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26743
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17113
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 217
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 137
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 142
  bin: 9.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 16
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1712
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5024
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 18
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 1.25e1
  variant carriers: 0
hgvs: p.Ile235Thr
num of homozygotes: 0
population: Latino
population: European (Finnish)
population: European (Non-Finnish)
population: East Asian
population: South Asian
population: Other
population: African
reference allele: A
site quality: MQ
site quality: ClippingRankSum
site quality: ReadPosRankSum
site quality: DP
site quality: VQSLOD
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: BaseQRankSum
site quality: QD
site quality: FS

22-22892402-G-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892402
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892402
    reference: chr 22
allele count: 1
allele frequency: 8.242120532770671e-6
allele num: 121328
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.699C>G
  hgvsp: ENSP00000385198.1:p.Asp233Glu
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.651C>G
  hgvsp: ENSP00000407342.2:p.Asp217Glu
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.651C>G
  hgvsp: ENSP00000445097.1:p.Asp217Glu
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.699C>G
  hgvsp: ENSP00000381728.2:p.Asp233Glu
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.699C>G
  hgvsp: ENSP00000381726.1:p.Asp233Glu
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.699C>G
  hgvsp: ENSP00000384343.3:p.Asp233Glu
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1634C>G
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.699C>G
  hgvsp: ENSP00000445675.1:p.Asp233Glu
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 69
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 276
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 217
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 95
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 613
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 403
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8898
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1574
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 56
  bin: 8.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 26734
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 958
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17119
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 137
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 142
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3272
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3949
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2001
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 29721
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 11
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 30
  bin: 2.25e1
  variant carriers: 0
hgvs: p.Asp233Glu
num of homozygotes: 0
population: African
population: Latino
population: South Asian
population: Other
population: East Asian
population: European (Non-Finnish)
population: European (Finnish)
reference allele: G
site quality: MQRankSum
site quality: BaseQRankSum
site quality: MQ
site quality: DP
site quality: VQSLOD
site quality: InbreedingCoeff
site quality: ReadPosRankSum
site quality: FS
site quality: QD
site quality: ClippingRankSum

22-22892403-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892403
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892403
    reference: chr 22
allele count: 1
allele frequency: 8.241984669908513e-6
allele num: 121330
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.650A>G
  hgvsp: ENSP00000407342.2:p.Asp217Gly
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.698A>G
  hgvsp: ENSP00000385198.1:p.Asp233Gly
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.650A>G
  hgvsp: ENSP00000445097.1:p.Asp217Gly
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.698A>G
  hgvsp: ENSP00000384343.3:p.Asp233Gly
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1633A>G
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.698A>G
  hgvsp: ENSP00000445675.1:p.Asp233Gly
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.698A>G
  hgvsp: ENSP00000381728.2:p.Asp233Gly
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.698A>G
  hgvsp: ENSP00000381726.1:p.Asp233Gly
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 403
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1574
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 613
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 41
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 217
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 275
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8899
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 958
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 96
  bin: 7.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 17121
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 138
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 69
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26731
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3273
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 142
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6182
  bin: 9.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 10
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2002
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 19
  bin: 3.75e1
  variant carriers: 0
hgvs: p.Asp233Gly
num of homozygotes: 0
population: South Asian
population: Latino
population: East Asian
population: European (Finnish)
population: European (Non-Finnish)
population: African
population: Other
reference allele: T
site quality: QD
site quality: ClippingRankSum
site quality: FS
site quality: ReadPosRankSum
site quality: DP
site quality: InbreedingCoeff
site quality: MQRankSum
site quality: VQSLOD
site quality: BaseQRankSum
site quality: MQ

22-22892409-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892409
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892409
    reference: chr 22
allele count: 1
allele frequency: 8.241712957621112e-6
allele num: 121334
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.692A>G
  hgvsp: ENSP00000381728.2:p.Gln231Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.692A>G
  hgvsp: ENSP00000381726.1:p.Gln231Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.644A>G
  hgvsp: ENSP00000407342.2:p.Gln215Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.692A>G
  hgvsp: ENSP00000384343.3:p.Gln231Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.692A>G
  hgvsp: ENSP00000385198.1:p.Gln231Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.644A>G
  hgvsp: ENSP00000445097.1:p.Gln215Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1627A>G
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.692A>G
  hgvsp: ENSP00000445675.1:p.Gln231Arg
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 137
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 218
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1575
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 142
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 69
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 613
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 95
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 275
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 403
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17132
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8904
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 957
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26714
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3278
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 9.25e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 3
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 10
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 14
  bin: 4.75e1
  variant carriers: 0
hgvs: p.Gln231Arg
num of homozygotes: 0
population: South Asian
population: Latino
population: African
population: European (Finnish)
population: East Asian
population: European (Non-Finnish)
population: Other
reference allele: T
site quality: MQRankSum
site quality: FS
site quality: QD
site quality: ClippingRankSum
site quality: BaseQRankSum
site quality: VQSLOD
site quality: InbreedingCoeff
site quality: ReadPosRankSum
site quality: MQ
site quality: DP

22-22892413-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892413
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892413
    reference: chr 22
allele count: 1
allele frequency: 8.241712957621112e-6
allele num: 121334
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.688G>A
  hgvsp: ENSP00000381728.2:p.Val230Met
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.640G>A
  hgvsp: ENSP00000407342.2:p.Val214Met
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.640G>A
  hgvsp: ENSP00000445097.1:p.Val214Met
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.688G>A
  hgvsp: ENSP00000384343.3:p.Val230Met
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1623G>A
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.688G>A
  hgvsp: ENSP00000445675.1:p.Val230Met
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.688G>A
  hgvsp: ENSP00000385198.1:p.Val230Met
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.688G>A
  hgvsp: ENSP00000381726.1:p.Val230Met
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 8905
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 957
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 9.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 1578
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 403
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 275
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 614
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3276
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 95
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26715
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 218
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17135
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 69
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 137
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 142
  bin: 9.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 1.75e1
  variant carriers: 0
hgvs: p.Val230Met
num of homozygotes: 0
population: European (Finnish)
population: Latino
population: African
population: South Asian
population: European (Non-Finnish)
population: East Asian
population: Other
reference allele: C
site quality: DP
site quality: ReadPosRankSum
site quality: BaseQRankSum
site quality: MQRankSum
site quality: ClippingRankSum
site quality: QD
site quality: MQ
site quality: InbreedingCoeff
site quality: FS
site quality: VQSLOD

22-22892417-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892417
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892417
    reference: chr 22
allele count: 1
allele frequency: 8.241712957621112e-6
allele num: 121334
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.684A>G
  hgvsp: ENST00000398743.2:c.684A>G(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.636A>G
  hgvsp: ENST00000424204.2:c.636A>G(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1619A>G
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.684A>G
  hgvsp: ENST00000405655.3:c.684A>G(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.684A>G
  hgvsp: ENST00000402697.1:c.684A>G(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.684A>G
  hgvsp: ENST00000543184.1:c.684A>G(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.636A>G
  hgvsp: ENST00000539862.1:c.636A>G(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.684A>G
  hgvsp: ENST00000398741.1:c.684A>G(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1576
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3278
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 24
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 219
  bin: 6.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 69
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 137
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 403
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 142
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8908
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 958
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26708
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 276
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17140
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 95
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 615
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3577
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6186
  bin: 9.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2003
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8395
  bin: 6.75e1
  variant carriers: 0
hgvs: p.Lys228Lys
num of homozygotes: 0
population: European (Non-Finnish)
population: African
population: East Asian
population: European (Finnish)
population: Latino
population: South Asian
population: Other
reference allele: T
site quality: FS
site quality: DP
site quality: MQ
site quality: ReadPosRankSum
site quality: BaseQRankSum
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: VQSLOD
site quality: QD
site quality: ClippingRankSum

22-22892426-C-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892426
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892426
    reference: chr 22
allele count: 4
allele frequency: 3.296413502109704e-5
allele num: 121344
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.627G>C
  hgvsp: ENSP00000445097.1:p.Met209Ile
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.675G>C
  hgvsp: ENSP00000381726.1:p.Met225Ile
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.627G>C
  hgvsp: ENSP00000407342.2:p.Met209Ile
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.675G>C
  hgvsp: ENSP00000384343.3:p.Met225Ile
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.675G>C
  hgvsp: ENSP00000445675.1:p.Met225Ile
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1610G>C
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.675G>C
  hgvsp: ENSP00000385198.1:p.Met225Ile
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.675G>C
  hgvsp: ENSP00000381728.2:p.Met225Ile
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 16
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3279
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8913
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17148
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 403
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 219
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 137
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 959
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 276
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1577
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 96
  bin: 7.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 26702
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 144
  bin: 9.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 615
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 56
  bin: 8.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 69
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3578
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 29742
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 7
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 10
  bin: 4.75e1
  variant carriers: 0
hgvs: p.Met225Ile
num of homozygotes: 0
population: European (Non-Finnish)
population: Latino
population: Other
population: East Asian
population: African
population: South Asian
population: European (Finnish)
reference allele: C
site quality: MQ
site quality: FS
site quality: MQRankSum
site quality: QD
site quality: ClippingRankSum
site quality: DP
site quality: InbreedingCoeff
site quality: BaseQRankSum
site quality: VQSLOD
site quality: ReadPosRankSum

22-22892426-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892426
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892426
    reference: chr 22
allele count: 1
allele frequency: 8.241033755274261e-6
allele num: 121344
alternate allele: T
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.675G>A
  hgvsp: ENSP00000445675.1:p.Met225Ile
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.675G>A
  hgvsp: ENSP00000381728.2:p.Met225Ile
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1610G>A
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.675G>A
  hgvsp: ENSP00000381726.1:p.Met225Ile
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.675G>A
  hgvsp: ENSP00000384343.3:p.Met225Ile
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.627G>A
  hgvsp: ENSP00000445097.1:p.Met209Ile
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.675G>A
  hgvsp: ENSP00000385198.1:p.Met225Ile
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.627G>A
  hgvsp: ENSP00000407342.2:p.Met209Ile
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 403
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 137
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17148
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8913
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 56
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 144
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 69
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3279
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26702
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 959
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 276
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 615
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 96
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1577
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 219
  bin: 6.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 3578
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 29742
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3
  bin: 1.25e1
  variant carriers: 0
hgvs: p.Met225Ile
num of homozygotes: 0
population: African
population: Latino
population: European (Non-Finnish)
population: East Asian
population: European (Finnish)
population: South Asian
population: Other
reference allele: C
site quality: MQ
site quality: QD
site quality: ReadPosRankSum
site quality: MQRankSum
site quality: FS
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: VQSLOD
site quality: InbreedingCoeff
site quality: DP

22-22892430-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892430
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892430
    reference: chr 22
allele count: 8
allele frequency: 6.592935669430205e-5
allele num: 121342
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.623A>G
  hgvsp: ENSP00000445097.1:p.Lys208Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.671A>G
  hgvsp: ENSP00000381728.2:p.Lys224Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.671A>G
  hgvsp: ENSP00000381726.1:p.Lys224Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1606A>G
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.623A>G
  hgvsp: ENSP00000407342.2:p.Lys208Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.671A>G
  hgvsp: ENSP00000384343.3:p.Lys224Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.671A>G
  hgvsp: ENSP00000445675.1:p.Lys224Arg
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.671A>G
  hgvsp: ENSP00000385198.1:p.Lys224Arg
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 1578
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 615
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 402
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 144
  bin: 9.75e1
  variant carriers: 4
genotype depth: GenotypeDepth
  all individuals: 26706
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8915
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17148
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 219
  bin: 6.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 8.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 959
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3278
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 136
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 71
  bin: 8.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 276
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 95
  bin: 7.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 2002
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 29753
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3578
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4
  bin: 4.25e1
  variant carriers: 0
hgvs: p.Lys224Arg
num of homozygotes: 0
population: European (Non-Finnish)
population: Other
population: African
population: European (Finnish)
population: Latino
population: South Asian
population: East Asian
reference allele: T
site quality: DP
site quality: MQRankSum
site quality: MQ
site quality: ReadPosRankSum
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: VQSLOD
site quality: FS
site quality: QD
site quality: InbreedingCoeff

22-22892431-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892431
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892431
    reference: chr 22
allele count: 1
allele frequency: 8.241169586787756e-6
allele num: 121342
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.670A>G
  hgvsp: ENSP00000381728.2:p.Lys224Glu
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.670A>G
  hgvsp: ENSP00000385198.1:p.Lys224Glu
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.670A>G
  hgvsp: ENSP00000445675.1:p.Lys224Glu
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1605A>G
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.622A>G
  hgvsp: ENSP00000407342.2:p.Lys208Glu
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.670A>G
  hgvsp: ENSP00000384343.3:p.Lys224Glu
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.622A>G
  hgvsp: ENSP00000445097.1:p.Lys208Glu
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.670A>G
  hgvsp: ENSP00000381726.1:p.Lys224Glu
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 218
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 276
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3278
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17149
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 136
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 54
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26706
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8915
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 405
  bin: 5.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 615
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 961
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 143
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1578
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 70
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 94
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1715
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5029
  bin: 7.75e1
  variant carriers: 0
hgvs: p.Lys224Glu
num of homozygotes: 0
population: African
population: European (Finnish)
population: East Asian
population: Other
population: Latino
population: South Asian
population: European (Non-Finnish)
reference allele: T
site quality: BaseQRankSum
site quality: MQRankSum
site quality: ClippingRankSum
site quality: VQSLOD
site quality: InbreedingCoeff
site quality: DP
site quality: FS
site quality: MQ
site quality: ReadPosRankSum
site quality: QD

22-22892432-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892432
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892432
    reference: chr 22
allele count: 1
allele frequency: 8.241305422778968e-6
allele num: 121340
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1604C>T
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.669C>T
  hgvsp: ENST00000543184.1:c.669C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.669C>T
  hgvsp: ENST00000402697.1:c.669C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.669C>T
  hgvsp: ENST00000398743.2:c.669C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.669C>T
  hgvsp: ENST00000405655.3:c.669C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.621C>T
  hgvsp: ENST00000539862.1:c.621C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.669C>T
  hgvsp: ENST00000398741.1:c.669C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.621C>T
  hgvsp: ENST00000424204.2:c.621C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 144
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1578
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 404
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26703
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 218
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 54
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8915
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3280
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 276
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 70
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17150
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 136
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 615
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 962
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 94
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1717
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 25
  bin: 2.25e1
  variant carriers: 0
hgvs: p.Ile223Ile
num of homozygotes: 0
population: Other
population: European (Non-Finnish)
population: South Asian
population: European (Finnish)
population: African
population: Latino
population: East Asian
reference allele: G
site quality: InbreedingCoeff
site quality: FS
site quality: QD
site quality: BaseQRankSum
site quality: DP
site quality: ClippingRankSum
site quality: ReadPosRankSum
site quality: VQSLOD
site quality: MQRankSum
site quality: MQ

22-22892436-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892436
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892436
    reference: chr 22
allele count: 1
allele frequency: 8.241033755274261e-6
allele num: 121344
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.665A>G
  hgvsp: ENSP00000381726.1:p.Asp222Gly
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1600A>G
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.665A>G
  hgvsp: ENSP00000381728.2:p.Asp222Gly
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.665A>G
  hgvsp: ENSP00000385198.1:p.Asp222Gly
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.617A>G
  hgvsp: ENSP00000445097.1:p.Asp206Gly
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.665A>G
  hgvsp: ENSP00000384343.3:p.Asp222Gly
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.665A>G
  hgvsp: ENSP00000445675.1:p.Asp222Gly
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.617A>G
  hgvsp: ENSP00000407342.2:p.Asp206Gly
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 94
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1579
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 615
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3279
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 136
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17153
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8915
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 71
  bin: 8.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 218
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 276
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26702
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 404
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 54
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 962
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 143
  bin: 9.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2002
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 7
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5029
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 29755
  bin: 6.25e1
  variant carriers: 0
hgvs: p.Asp222Gly
num of homozygotes: 0
population: South Asian
population: Other
population: European (Finnish)
population: East Asian
population: African
population: Latino
population: European (Non-Finnish)
reference allele: T
site quality: DP
site quality: BaseQRankSum
site quality: MQRankSum
site quality: QD
site quality: ReadPosRankSum
site quality: FS
site quality: InbreedingCoeff
site quality: VQSLOD
site quality: ClippingRankSum
site quality: MQ

http://identifiers.org/exac.variant/22-22892437-C-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22892437
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22892437
    reference: chr 22
allele count: 1
allele frequency: 8.241305422778968e-6
allele num: 121340
alternate allele: A
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445675
  ensembl transcript: ENST00000543184
  gene symbol: PRAME
  hgvsc: ENST00000543184.1:c.664G>T
  hgvsp: ENSP00000445675.1:p.Asp222Tyr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381726
  ensembl transcript: ENST00000398741
  gene symbol: PRAME
  hgvsc: ENST00000398741.1:c.664G>T
  hgvsp: ENSP00000381726.1:p.Asp222Tyr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000385198
  ensembl transcript: ENST00000402697
  gene symbol: PRAME
  hgvsc: ENST00000402697.1:c.664G>T
  hgvsp: ENSP00000385198.1:p.Asp222Tyr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000407342
  ensembl transcript: ENST00000424204
  gene symbol: PRAME
  hgvsc: ENST00000424204.2:c.616G>T
  hgvsp: ENSP00000407342.2:p.Asp206Tyr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000381728
  ensembl transcript: ENST00000398743
  gene symbol: PRAME
  hgvsc: ENST00000398743.2:c.664G>T
  hgvsp: ENSP00000381728.2:p.Asp222Tyr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000445097
  ensembl transcript: ENST00000539862
  gene symbol: PRAME
  hgvsc: ENST00000539862.1:c.616G>T
  hgvsp: ENSP00000445097.1:p.Asp206Tyr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000185686
  ensembl protein: ENSP00000384343
  ensembl transcript: ENST00000405655
  gene symbol: PRAME
  hgvsc: ENST00000405655.3:c.664G>T
  hgvsp: ENSP00000384343.3:p.Asp222Tyr
  variant of: http://identifiers.org/hgnc/9336
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000185686
  ensembl transcript: ENST00000492657
  gene symbol: PRAME
  hgvsc: ENST00000492657.1:n.1599G>T
  variant of: http://identifiers.org/hgnc/9336
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 615
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1582
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 218
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 94
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 54
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17155
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3278
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26699
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 276
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8915
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 137
  bin: 7.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 7.5e0
  variant carriers: 0
hgvs: p.Asp222Tyr
num of homozygotes: 0
reference allele: C

GenotypeQuality
all individuals: 30377
bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 0
bin: 1.25e1
variant carriers: 0

GenotypeQuality
all individuals: 4512
bin: 9.75e1
variant carriers: 1

GenotypeQuality
all individuals: 18
bin: 7.5e0
variant carriers: 0

GenotypeQuality
all individuals: 1934
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 3
bin: 2.5e0
variant carriers: 0

GenotypeQuality
all individuals: 84
bin: 3.25e1
variant carriers: 0

GenotypeQuality
all individuals: 72
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 436
bin: 2.25e1
variant carriers: 0

GenotypeQuality
all individuals: 40
bin: 5.75e1
variant carriers: 0

GenotypeQuality
all individuals: 5163
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 1683
bin: 8.75e1
variant carriers: 0

GenotypeQuality
all individuals: 53
bin: 4.75e1
variant carriers: 0

GenotypeQuality
all individuals: 3588
bin: 8.25e1
variant carriers: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6606
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8576
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16276
num of homozygotes: 0

Latino
type: Population
allele count: 1
allele frequency: 8.671522719389525e-5
allele num: 11532
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66344
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10370
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 898
num of homozygotes: 0

ClippingRankSum
type: SiteQuality
SIO_000300: -2.78e-1

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.29e0

QD
type: SiteQuality
SIO_000300: 1.546e1

DP
type: SiteQuality
SIO_000300: 1.615275e6

MQ
type: SiteQuality
SIO_000300: 5.972e1

MQRankSum
type: SiteQuality
SIO_000300: 1.66e0

FS
type: SiteQuality
SIO_000300: 1.818e0

BaseQRankSum
type: SiteQuality
SIO_000300: 2.78e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: 6.5e-3

VQSLOD
type: SiteQuality
SIO_000300: 3.1e-2

GenotypeQuality
all individuals: 34
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 30575
bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1696
bin: 8.75e1
variant carriers: 0

GenotypeQuality
all individuals: 37
bin: 5.75e1
variant carriers: 0

GenotypeQuality
all individuals: 16
bin: 7.5e0
variant carriers: 0

GenotypeQuality
all individuals: 1
bin: 1.75e1
variant carriers: 0

GenotypeQuality
all individuals: 4048
bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 43
bin: 3.25e1
variant carriers: 0

GenotypeQuality
all individuals: 5196
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 1939
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 39
bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 4525
bin: 9.75e1
variant carriers: 1

GenotypeQuality
all individuals: 3606
bin: 8.25e1
variant carriers: 0

GenotypeQuality
all individuals: 8566
bin: 6.75e1
variant carriers: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8620
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 900
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66468
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6610
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10378
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11550
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.097560975609756e-5
allele num: 16400
num of homozygotes: 0

DP
type: SiteQuality
SIO_000300: 1.62075e6

InbreedingCoeff
type: SiteQuality
SIO_000300: 5.999999999999999e-4

VQSLOD
type: SiteQuality
SIO_000300: 1.02e0

ReadPosRankSum
type: SiteQuality
SIO_000300: -4.45e-1

FS
type: SiteQuality
SIO_000300: 2.996e0

ClippingRankSum
type: SiteQuality
SIO_000300: -6.27e-1

QD
type: SiteQuality
SIO_000300: 1.297e1

MQ
type: SiteQuality
SIO_000300: 5.975e1

BaseQRankSum
type: SiteQuality
SIO_000300: 4.2e0

MQRankSum
type: SiteQuality
SIO_000300: 2.41e-1

GenotypeQuality
all individuals: 15
bin: 7.5e0
variant carriers: 0

GenotypeQuality
all individuals: 1695
bin: 8.75e1
variant carriers: 0

GenotypeQuality
all individuals: 30583
bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 60
bin: 5.25e1
variant carriers: 0

GenotypeQuality
all individuals: 32
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 3
bin: 1.75e1
variant carriers: 0

GenotypeQuality
all individuals: 34
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 4524
bin: 9.75e1
variant carriers: 1

GenotypeQuality
all individuals: 3609
bin: 8.25e1
variant carriers: 0

GenotypeQuality
all individuals: 207
bin: 2.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1940
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 4046
bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 47
bin: 4.75e1
variant carriers: 0

GenotypeQuality
all individuals: 8582
bin: 6.75e1
variant carriers: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16440
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10378
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 898
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11556
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6610
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8630
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.503714174009804e-5
allele num: 66502
num of homozygotes: 0

QD
type: SiteQuality
SIO_000300: 1.327e1

FS
type: SiteQuality
SIO_000300: 0.0e0

MQ
type: SiteQuality
SIO_000300: 5.905e1

MQRankSum
type: SiteQuality
SIO_000300: -1.14e-1

VQSLOD
type: SiteQuality
SIO_000300: 1.08e-1

DP
type: SiteQuality
SIO_000300: 1.62264e6

InbreedingCoeff
type: SiteQuality
SIO_000300: 4.0e-4

BaseQRankSum
type: SiteQuality
SIO_000300: -6.575e0

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.82e0

ClippingRankSum
type: SiteQuality
SIO_000300: -1.536e0

GenotypeQuality
all individuals: 14
bin: 4.75e1
variant carriers: 0

GenotypeQuality
all individuals: 2
bin: 2.5e0
variant carriers: 0

GenotypeQuality
all individuals: 116
bin: 2.25e1
variant carriers: 0

GenotypeQuality
all individuals: 4531
bin: 9.75e1
variant carriers: 1

GenotypeQuality
all individuals: 15
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1951
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 19
bin: 3.25e1
variant carriers: 0

GenotypeQuality
all individuals: 20
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 3
bin: 1.75e1
variant carriers: 0

GenotypeQuality
all individuals: 28
bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 3619
bin: 8.25e1
variant carriers: 0

GenotypeQuality
all individuals: 4064
bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 19
bin: 5.75e1
variant carriers: 0

GenotypeQuality
all individuals: 8619
bin: 6.75e1
variant carriers: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8640
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11564
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6610
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 906
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66564
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10386
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.065752759917505e-5
allele num: 16486
num of homozygotes: 0

MQRankSum
type: SiteQuality
SIO_000300: 3.3e-2

ClippingRankSum
type: SiteQuality
SIO_000300: -1.457e0

InbreedingCoeff
type: SiteQuality
SIO_000300: -3.0e-4

QD
type: SiteQuality
SIO_000300: 1.622e1

VQSLOD
type: SiteQuality
SIO_000300: 2.08e-1

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.87e0

DP
type: SiteQuality
SIO_000300: 1.62533e6

MQ
type: SiteQuality
SIO_000300: 5.938e1

FS
type: SiteQuality
SIO_000300: 0.0e0

BaseQRankSum
type: SiteQuality
SIO_000300: -2.588e0

GenotypeQuality
all individuals: 13
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 11
bin: 7.5e0
variant carriers: 0

GenotypeQuality
all individuals: 30797
bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 11
bin: 5.25e1
variant carriers: 0

GenotypeQuality
all individuals: 9
bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 4071
bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1
bin: 1.25e1
variant carriers: 0

GenotypeQuality
all individuals: 74
bin: 2.25e1
variant carriers: 0

GenotypeQuality
all individuals: 4537
bin: 9.75e1
variant carriers: 1

GenotypeQuality
all individuals: 8
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1950
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 8632
bin: 6.75e1
variant carriers: 0

GenotypeQuality
all individuals: 9
bin: 5.75e1
variant carriers: 0

GenotypeQuality
all individuals: 5217
bin: 7.75e1
variant carriers: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10390
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8646
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6612
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 906
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.501321162623108e-5
allele num: 66608
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11572
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16502
num of homozygotes: 0

FS
type: SiteQuality
SIO_000300: 9.2e-1

ClippingRankSum
type: SiteQuality
SIO_000300: -2.23e-1

QD
type: SiteQuality
SIO_000300: 1.166e1

InbreedingCoeff
type: SiteQuality
SIO_000300: -2.0e-4

ReadPosRankSum
type: SiteQuality
SIO_000300: -2.9e-2

BaseQRankSum
type: SiteQuality
SIO_000300: 2.45e0

DP
type: SiteQuality
SIO_000300: 1.626479e6

VQSLOD
type: SiteQuality
SIO_000300: 1.91e0

MQRankSum
type: SiteQuality
SIO_000300: 7.199999999999999e-2

MQ
type: SiteQuality
SIO_000300: 6.0e1

GenotypeQuality
all individuals: 0
bin: 2.5e0
variant carriers: 0

GenotypeQuality
all individuals: 10
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 11
bin: 3.25e1
variant carriers: 0

GenotypeQuality
all individuals: 65
bin: 2.25e1
variant carriers: 0

GenotypeQuality
all individuals: 4072
bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1950
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 11
bin: 5.25e1
variant carriers: 0

GenotypeQuality
all individuals: 8
bin: 5.75e1
variant carriers: 0

GenotypeQuality
all individuals: 4539
bin: 9.75e1
variant carriers: 1

GenotypeQuality
all individuals: 5216
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 30807
bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 8633
bin: 6.75e1
variant carriers: 0

GenotypeQuality
all individuals: 1709
bin: 8.75e1
variant carriers: 0

GenotypeQuality
all individuals: 9
bin: 3.75e1
variant carriers: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

East Asian
type: Population
allele count: 1
allele frequency: 1.156336725254394e-4
allele num: 8648
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6612
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11572
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10394
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16504
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66626
num of homozygotes: 0

BaseQRankSum
type: SiteQuality
SIO_000300: -2.203e0

QD
type: SiteQuality
SIO_000300: 1.141e1

VQSLOD
type: SiteQuality
SIO_000300: 3.78e-1

MQ
type: SiteQuality
SIO_000300: 5.96e1

DP
type: SiteQuality
SIO_000300: 1.626845e6

ReadPosRankSum
type: SiteQuality
SIO_000300: 8.69e-1

ClippingRankSum
type: SiteQuality
SIO_000300: -1.357e0

MQRankSum
type: SiteQuality
SIO_000300: 1.2e0

FS
type: SiteQuality
SIO_000300: 8.63e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: -3.0e-4

GenotypeQuality
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bin: 6.25e1
variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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bin: 4.25e1
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GenotypeQuality
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bin: 5.25e1
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GenotypeQuality
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bin: 7.75e1
variant carriers: 0

GenotypeQuality
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bin: 3.75e1
variant carriers: 0

GenotypeQuality
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bin: 4.75e1
variant carriers: 0

GenotypeQuality
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bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 3630
bin: 8.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1711
bin: 8.75e1
variant carriers: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6612
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11574
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10396
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.056935190793458e-5
allele num: 16510
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66664
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

QD
type: SiteQuality
SIO_000300: 1.276e1

VQSLOD
type: SiteQuality
SIO_000300: 1.31e0

DP
type: SiteQuality
SIO_000300: 1.627669e6

ReadPosRankSum
type: SiteQuality
SIO_000300: 2.52e-1

ClippingRankSum
type: SiteQuality
SIO_000300: -8.0e-1

MQRankSum
type: SiteQuality
SIO_000300: -1.47e-1

BaseQRankSum
type: SiteQuality
SIO_000300: 1.53e0

InbreedingCoeff
type: SiteQuality
SIO_000300: -1.0e-4

MQ
type: SiteQuality
SIO_000300: 5.98e1

FS
type: SiteQuality
SIO_000300: 2.367e0

GenotypeQuality
all individuals: 2
bin: 4.25e1
variant carriers: 0

GenotypeQuality
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bin: 2.5e0
variant carriers: 0

GenotypeQuality
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bin: 1.25e1
variant carriers: 0

GenotypeQuality
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bin: 9.25e1
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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bin: 4.75e1
variant carriers: 0

GenotypeQuality
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bin: 3.25e1
variant carriers: 0

GenotypeQuality
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bin: 5.75e1
variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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bin: 2.25e1
variant carriers: 0

GenotypeQuality
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bin: 8.25e1
variant carriers: 0

GenotypeQuality
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bin: 6.25e1
variant carriers: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11574
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10400
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.500015000150001e-5
allele num: 66666
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16512
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6612
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

BaseQRankSum
type: SiteQuality
SIO_000300: -3.899e0

ClippingRankSum
type: SiteQuality
SIO_000300: 8.5e-1

DP
type: SiteQuality
SIO_000300: 1.627721e6

QD
type: SiteQuality
SIO_000300: 1.111e1

MQRankSum
type: SiteQuality
SIO_000300: -8.06e-1

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.39e-1

FS
type: SiteQuality
SIO_000300: 3.804e0

VQSLOD
type: SiteQuality
SIO_000300: 1.61e-1

MQ
type: SiteQuality
SIO_000300: 5.922e1

InbreedingCoeff
type: SiteQuality
SIO_000300: -1.0e-4

GenotypeQuality
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bin: 3.25e1
variant carriers: 0

GenotypeQuality
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bin: 4.75e1
variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
all individuals: 8
bin: 5.75e1
variant carriers: 0

GenotypeQuality
all individuals: 3630
bin: 8.25e1
variant carriers: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.500015000150001e-5
allele num: 66666
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10400
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11574
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16512
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6612
num of homozygotes: 0

VQSLOD
type: SiteQuality
SIO_000300: -3.245e0

MQ
type: SiteQuality
SIO_000300: 5.964e1

DP
type: SiteQuality
SIO_000300: 1.627872e6

MQRankSum
type: SiteQuality
SIO_000300: -4.5e-2

ClippingRankSum
type: SiteQuality
SIO_000300: 2.3e-2

InbreedingCoeff
type: SiteQuality
SIO_000300: 1.0e-4

FS
type: SiteQuality
SIO_000300: 2.066e1

BaseQRankSum
type: SiteQuality
SIO_000300: 6.1e0

QD
type: SiteQuality
SIO_000300: 1.03e0

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.41e0

GenotypeQuality
all individuals: 5
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variant carriers: 0

GenotypeQuality
all individuals: 4
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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bin: 8.75e1
variant carriers: 0

GenotypeQuality
all individuals: 30842
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variant carriers: 0

GenotypeQuality
all individuals: 5218
bin: 7.75e1
variant carriers: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11574
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.056201550387597e-5
allele num: 16512
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10400
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66670
num of homozygotes: 0

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.64e0

QD
type: SiteQuality
SIO_000300: 1.216e1

FS
type: SiteQuality
SIO_000300: 2.242e0

MQRankSum
type: SiteQuality
SIO_000300: 9.429999999999999e-1

ClippingRankSum
type: SiteQuality
SIO_000300: -1.636e0

VQSLOD
type: SiteQuality
SIO_000300: -7.14e-1

BaseQRankSum
type: SiteQuality
SIO_000300: 1.56e0

MQ
type: SiteQuality
SIO_000300: 5.879e1

InbreedingCoeff
type: SiteQuality
SIO_000300: -1.0e-4

DP
type: SiteQuality
SIO_000300: 1.62796e6

GenotypeQuality
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bin: 8.25e1
variant carriers: 0

GenotypeQuality
all individuals: 5
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variant carriers: 0

GenotypeQuality
all individuals: 3
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 4

GenotypeQuality
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GenotypeQuality
all individuals: 0
bin: 5.75e1
variant carriers: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

South Asian
type: Population
allele count: 4
allele frequency: 2.422480620155039e-4
allele num: 16512
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10400
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66668
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11574
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

ReadPosRankSum
type: SiteQuality
SIO_000300: 2.0e0

MQRankSum
type: SiteQuality
SIO_000300: 7.77e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: -1.0e-4

QD
type: SiteQuality
SIO_000300: 1.154e1

MQ
type: SiteQuality
SIO_000300: 5.982e1

VQSLOD
type: SiteQuality
SIO_000300: 6.12e-1

DP
type: SiteQuality
SIO_000300: 1.628169e6

FS
type: SiteQuality
SIO_000300: 9.370000000000001e-1

BaseQRankSum
type: SiteQuality
SIO_000300: 2.31e0

ClippingRankSum
type: SiteQuality
SIO_000300: -2.01e-1

GenotypeQuality
all individuals: 3595
bin: 8.25e1
variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
all individuals: 7
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
all individuals: 7
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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variant carriers: 587

GenotypeQuality
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variant carriers: 0

GenotypeQuality
all individuals: 6
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variant carriers: 0

European (Non-Finnish)
type: Population
allele count: 385
allele frequency: 5.774364819869814e-3
allele num: 66674
num of homozygotes: 1

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

African
type: Population
allele count: 9
allele frequency: 8.653846153846154e-4
allele num: 10400
num of homozygotes: 0

South Asian
type: Population
allele count: 72
allele frequency: 4.36046511627907e-3
allele num: 16512
num of homozygotes: 2

Latino
type: Population
allele count: 10
allele frequency: 8.640055296353896e-4
allele num: 11574
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 109
allele frequency: 1.648019352887814e-2
allele num: 6614
num of homozygotes: 1

Other
type: Population
allele count: 6
allele frequency: 6.607929515418502e-3
allele num: 908
num of homozygotes: 0

MQRankSum
type: SiteQuality
SIO_000300: 2.93e-1

FS
type: SiteQuality
SIO_000300: 5.3e-1

ClippingRankSum
type: SiteQuality
SIO_000300: -1.32e-1

BaseQRankSum
type: SiteQuality
SIO_000300: -2.792e0

QD
type: SiteQuality
SIO_000300: 1.296e1

DP
type: SiteQuality
SIO_000300: 1.668906e6

MQ
type: SiteQuality
SIO_000300: 5.966e1

VQSLOD
type: SiteQuality
SIO_000300: 4.65e0

InbreedingCoeff
type: SiteQuality
SIO_000300: 7.5e-3

ReadPosRankSum
type: SiteQuality
SIO_000300: 5.71e-1

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 8.25e1
variant carriers: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66674
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10400
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11574
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.056201550387597e-5
allele num: 16512
num of homozygotes: 0

QD
type: SiteQuality
SIO_000300: 8.24e0

FS
type: SiteQuality
SIO_000300: 7.59e-1

MQ
type: SiteQuality
SIO_000300: 5.849e1

VQSLOD
type: SiteQuality
SIO_000300: -2.93e0

MQRankSum
type: SiteQuality
SIO_000300: 1.82e0

InbreedingCoeff
type: SiteQuality
SIO_000300: -1.0e-4

ReadPosRankSum
type: SiteQuality
SIO_000300: -9.06e-1

BaseQRankSum
type: SiteQuality
SIO_000300: -1.154e0

ClippingRankSum
type: SiteQuality
SIO_000300: 1.08e0

DP
type: SiteQuality
SIO_000300: 1.642462e6

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
all individuals: 23
bin: 2.25e1
variant carriers: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10400
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.056201550387597e-5
allele num: 16512
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11574
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.499700059988002e-5
allele num: 66680
num of homozygotes: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

DP
type: SiteQuality
SIO_000300: 1.642552e6

MQRankSum
type: SiteQuality
SIO_000300: 7.23e-1

ReadPosRankSum
type: SiteQuality
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BaseQRankSum
type: SiteQuality
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FS
type: SiteQuality
SIO_000300: 4.973e0

MQ
type: SiteQuality
SIO_000300: 5.956e1

InbreedingCoeff
type: SiteQuality
SIO_000300: -2.0e-4

VQSLOD
type: SiteQuality
SIO_000300: 7.5e-1

QD
type: SiteQuality
SIO_000300: 1.174e1

ClippingRankSum
type: SiteQuality
SIO_000300: -3.07e-1

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 6.75e1
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
all individuals: 1710
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
all individuals: 1
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variant carriers: 0

GenotypeQuality
all individuals: 4045
bin: 7.25e1
variant carriers: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16512
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.499655079331754e-5
allele num: 66682
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11574
num of homozygotes: 0

European (Finnish)
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East Asian
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African
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BaseQRankSum
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SIO_000300: -2.623e0

MQ
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MQRankSum
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DP
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FS
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VQSLOD
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InbreedingCoeff
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ClippingRankSum
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QD
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ReadPosRankSum
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SIO_000300: 1.94e0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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Latino
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num of homozygotes: 0

East Asian
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Other
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African
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allele frequency: 1.923076923076923e-4
allele num: 10400
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European (Non-Finnish)
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allele num: 66682
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European (Finnish)
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South Asian
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FS
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MQRankSum
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InbreedingCoeff
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BaseQRankSum
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ReadPosRankSum
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MQ
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QD
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VQSLOD
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ClippingRankSum
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DP
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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South Asian
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European (Finnish)
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East Asian
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African
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European (Non-Finnish)
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Latino
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InbreedingCoeff
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VQSLOD
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QD
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FS
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DP
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MQ
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ReadPosRankSum
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ClippingRankSum
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MQRankSum
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BaseQRankSum
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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European (Non-Finnish)
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African
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Other
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European (Finnish)
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East Asian
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Latino
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South Asian
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ClippingRankSum
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QD
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MQ
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MQRankSum
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VQSLOD
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BaseQRankSum
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FS
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ReadPosRankSum
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DP
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InbreedingCoeff
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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Latino
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European (Finnish)
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European (Non-Finnish)
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East Asian
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African
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South Asian
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Other
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MQRankSum
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QD
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FS
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ClippingRankSum
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MQ
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DP
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ReadPosRankSum
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InbreedingCoeff
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BaseQRankSum
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VQSLOD
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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East Asian
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European (Non-Finnish)
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European (Finnish)
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Other
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Latino
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African
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South Asian
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MQRankSum
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FS
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VQSLOD
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QD
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BaseQRankSum
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ReadPosRankSum
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InbreedingCoeff
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MQ
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ClippingRankSum
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DP
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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South Asian
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African
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Latino
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European (Non-Finnish)
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European (Finnish)
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East Asian
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Other
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FS
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MQRankSum
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QD
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ReadPosRankSum
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VQSLOD
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InbreedingCoeff
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ClippingRankSum
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DP
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MQ
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BaseQRankSum
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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African
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South Asian
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European (Non-Finnish)
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East Asian
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European (Finnish)
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Latino
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ClippingRankSum
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FS
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InbreedingCoeff
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QD
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BaseQRankSum
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ReadPosRankSum
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VQSLOD
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MQ
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DP
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MQRankSum
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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African
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European (Finnish)
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Other
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Latino
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South Asian
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European (Non-Finnish)
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East Asian
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VQSLOD
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ClippingRankSum
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FS
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BaseQRankSum
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MQRankSum
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InbreedingCoeff
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DP
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QD
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MQ
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ReadPosRankSum
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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allele frequency: 0.0e0
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num of homozygotes: 0

Latino
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allele frequency: 0.0e0
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East Asian
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allele frequency: 0.0e0
allele num: 8648
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European (Non-Finnish)
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allele frequency: 1.499565126113427e-5
allele num: 66686
num of homozygotes: 0

European (Finnish)
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allele frequency: 0.0e0
allele num: 6614
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Other
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South Asian
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FS
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BaseQRankSum
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VQSLOD
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ClippingRankSum
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MQRankSum
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DP
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QD
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InbreedingCoeff
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MQ
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ReadPosRankSum
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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num of homozygotes: 0

East Asian
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allele frequency: 0.0e0
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European (Non-Finnish)
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Other
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European (Finnish)
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allele frequency: 0.0e0
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African
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South Asian
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DP
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BaseQRankSum
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ReadPosRankSum
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FS
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MQRankSum
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InbreedingCoeff
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MQ
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ClippingRankSum
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VQSLOD
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QD
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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European (Finnish)
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allele frequency: 0.0e0
allele num: 6614
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Other
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South Asian
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allele frequency: 0.0e0
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European (Non-Finnish)
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African
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East Asian
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allele frequency: 5.783021050196623e-4
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InbreedingCoeff
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ClippingRankSum
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ReadPosRankSum
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BaseQRankSum
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QD
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DP
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MQ
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VQSLOD
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FS
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MQRankSum
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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East Asian
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num of homozygotes: 0

African
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allele frequency: 0.0e0
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European (Non-Finnish)
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

Latino
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allele frequency: 0.0e0
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European (Finnish)
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

Other
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South Asian
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allele frequency: 6.056935190793458e-5
allele num: 16510
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QD
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MQ
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BaseQRankSum
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InbreedingCoeff
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ClippingRankSum
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FS
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VQSLOD
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MQRankSum
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SIO_000300: 3.3e-2

ReadPosRankSum
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DP
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SIO_000300: 1.643259e6

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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East Asian
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

Latino
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allele count: 0
allele frequency: 0.0e0
allele num: 11574
num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
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South Asian
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allele count: 0
allele frequency: 0.0e0
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African
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allele frequency: 0.0e0
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European (Non-Finnish)
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allele count: 11
allele frequency: 1.649422702054281e-4
allele num: 66690
num of homozygotes: 0

Other
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allele count: 0
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BaseQRankSum
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FS
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DP
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InbreedingCoeff
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QD
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MQ
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ReadPosRankSum
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ClippingRankSum
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VQSLOD
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MQRankSum
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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European (Non-Finnish)
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allele count: 83
allele frequency: 1.244564402459139e-3
allele num: 66690
num of homozygotes: 0

Other
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African
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East Asian
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Latino
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European (Finnish)
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South Asian
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ReadPosRankSum
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QD
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BaseQRankSum
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InbreedingCoeff
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MQ
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MQRankSum
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DP
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VQSLOD
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FS
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ClippingRankSum
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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African
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allele frequency: 9.617234083477592e-5
allele num: 10398
num of homozygotes: 0

Latino
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Other
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European (Non-Finnish)
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allele num: 66690
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East Asian
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European (Finnish)
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South Asian
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ReadPosRankSum
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QD
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DP
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FS
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MQRankSum
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MQ
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BaseQRankSum
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VQSLOD
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ClippingRankSum
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InbreedingCoeff
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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European (Non-Finnish)
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allele num: 66690
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European (Finnish)
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Other
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African
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South Asian
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Latino
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East Asian
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ClippingRankSum
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FS
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BaseQRankSum
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ReadPosRankSum
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InbreedingCoeff
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VQSLOD
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MQRankSum
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MQ
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DP
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QD
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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East Asian
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allele num: 8648
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African
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South Asian
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European (Non-Finnish)
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allele num: 66690
num of homozygotes: 0

European (Finnish)
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Other
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Latino
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VQSLOD
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ReadPosRankSum
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MQRankSum
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MQ
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InbreedingCoeff
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SIO_000300: 1.0e-4

ClippingRankSum
type: SiteQuality
SIO_000300: -4.5e-2

BaseQRankSum
type: SiteQuality
SIO_000300: -6.79e-1

FS
type: SiteQuality
SIO_000300: 0.0e0

DP
type: SiteQuality
SIO_000300: 1.646382e6

QD
type: SiteQuality
SIO_000300: 1.663e1

GenotypeQuality
all individuals: 0
bin: 1.25e1
variant carriers: 0

GenotypeQuality
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bin: 7.5e0
variant carriers: 0

GenotypeQuality
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GenotypeQuality
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bin: 2.5e0
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 8.25e1
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 3.25e1
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GenotypeQuality
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bin: 8.75e1
variant carriers: 0

GenotypeQuality
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bin: 9.75e1
variant carriers: 1

GenotypeQuality
all individuals: 6
bin: 5.75e1
variant carriers: 0

GenotypeQuality
all individuals: 9
bin: 4.25e1
variant carriers: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66690
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11574
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.056935190793458e-5
allele num: 16510
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10398
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

ClippingRankSum
type: SiteQuality
SIO_000300: -4.5e-2

BaseQRankSum
type: SiteQuality
SIO_000300: -6.79e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: 1.0e-4

FS
type: SiteQuality
SIO_000300: 0.0e0

MQ
type: SiteQuality
SIO_000300: 5.963e1

MQRankSum
type: SiteQuality
SIO_000300: 2.66e-1

ReadPosRankSum
type: SiteQuality
SIO_000300: 2.1e-1

QD
type: SiteQuality
SIO_000300: 1.663e1

DP
type: SiteQuality
SIO_000300: 1.646382e6

VQSLOD
type: SiteQuality
SIO_000300: 3.85e0

GenotypeQuality
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bin: 8.25e1
variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 10

GenotypeQuality
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GenotypeQuality
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bin: 9.25e1
variant carriers: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66690
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16510
num of homozygotes: 0

Latino
type: Population
allele count: 2
allele frequency: 1.728011059270779e-4
allele num: 11574
num of homozygotes: 0

African
type: Population
allele count: 8
allele frequency: 7.693787266782073e-4
allele num: 10398
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

MQ
type: SiteQuality
SIO_000300: 5.97e1

DP
type: SiteQuality
SIO_000300: 1.646782e6

BaseQRankSum
type: SiteQuality
SIO_000300: 1.8e-1

QD
type: SiteQuality
SIO_000300: 1.48e1

VQSLOD
type: SiteQuality
SIO_000300: 2.79e0

ReadPosRankSum
type: SiteQuality
SIO_000300: 2.46e-1

MQRankSum
type: SiteQuality
SIO_000300: 2.89e-1

FS
type: SiteQuality
SIO_000300: 2.419e0

InbreedingCoeff
type: SiteQuality
SIO_000300: -2.0e-4

ClippingRankSum
type: SiteQuality
SIO_000300: 8.2e-2

GenotypeQuality
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bin: 3.75e1
variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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bin: 2.5e0
variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
all individuals: 12
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variant carriers: 0

GenotypeQuality
all individuals: 1709
bin: 8.75e1
variant carriers: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16512
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.499565126113427e-5
allele num: 66686
num of homozygotes: 0

African
type: Population
allele count: 5
allele frequency: 4.808617041738796e-4
allele num: 10398
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11572
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

InbreedingCoeff
type: SiteQuality
SIO_000300: -2.0e-4

FS
type: SiteQuality
SIO_000300: 1.809e0

VQSLOD
type: SiteQuality
SIO_000300: 1.69e0

BaseQRankSum
type: SiteQuality
SIO_000300: 5.7e-1

QD
type: SiteQuality
SIO_000300: 1.188e1

MQ
type: SiteQuality
SIO_000300: 5.96e1

ClippingRankSum
type: SiteQuality
SIO_000300: 2.18e-1

MQRankSum
type: SiteQuality
SIO_000300: 6.31e-1

DP
type: SiteQuality
SIO_000300: 1.646955e6

ReadPosRankSum
type: SiteQuality
SIO_000300: -4.55e-1

GenotypeQuality
all individuals: 12
bin: 7.5e0
variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 9.75e1
variant carriers: 264

GenotypeQuality
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bin: 7.75e1
variant carriers: 0

European (Finnish)
type: Population
allele count: 1
allele frequency: 1.511944360447536e-4
allele num: 6614
num of homozygotes: 0

Other
type: Population
allele count: 1
allele frequency: 1.101321585903084e-3
allele num: 908
num of homozygotes: 0

South Asian
type: Population
allele count: 9
allele frequency: 5.451241671714113e-4
allele num: 16510
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 243
allele frequency: 3.643943256455628e-3
allele num: 66686
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

African
type: Population
allele count: 3
allele frequency: 2.885170225043277e-4
allele num: 10398
num of homozygotes: 0

Latino
type: Population
allele count: 7
allele frequency: 6.048038707447727e-4
allele num: 11574
num of homozygotes: 0

FS
type: SiteQuality
SIO_000300: 0.0e0

MQ
type: SiteQuality
SIO_000300: 5.968e1

QD
type: SiteQuality
SIO_000300: 1.296e1

DP
type: SiteQuality
SIO_000300: 1.664938e6

ClippingRankSum
type: SiteQuality
SIO_000300: -1.83e-1

VQSLOD
type: SiteQuality
SIO_000300: 5.58e0

InbreedingCoeff
type: SiteQuality
SIO_000300: -1.9e-3

BaseQRankSum
type: SiteQuality
SIO_000300: -9.56e-1

MQRankSum
type: SiteQuality
SIO_000300: 2.11e-1

ReadPosRankSum
type: SiteQuality
SIO_000300: 7.75e-1

GenotypeQuality
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bin: 4.75e1
variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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bin: 8.25e1
variant carriers: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.499565126113427e-5
allele num: 66686
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16510
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11574
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10398
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

QD
type: SiteQuality
SIO_000300: 1.296e1

InbreedingCoeff
type: SiteQuality
SIO_000300: -1.9e-3

MQRankSum
type: SiteQuality
SIO_000300: 2.11e-1

BaseQRankSum
type: SiteQuality
SIO_000300: -9.56e-1

FS
type: SiteQuality
SIO_000300: 0.0e0

ReadPosRankSum
type: SiteQuality
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MQ
type: SiteQuality
SIO_000300: 5.968e1

ClippingRankSum
type: SiteQuality
SIO_000300: -1.83e-1

VQSLOD
type: SiteQuality
SIO_000300: 5.58e0

DP
type: SiteQuality
SIO_000300: 1.664938e6

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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bin: 1.75e1
variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 9.75e1
variant carriers: 1

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10398
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.056935190793458e-5
allele num: 16510
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66688
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11574
num of homozygotes: 0

DP
type: SiteQuality
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FS
type: SiteQuality
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MQRankSum
type: SiteQuality
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BaseQRankSum
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VQSLOD
type: SiteQuality
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InbreedingCoeff
type: SiteQuality
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QD
type: SiteQuality
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ClippingRankSum
type: SiteQuality
SIO_000300: 7.16e-1

MQ
type: SiteQuality
SIO_000300: 6.0e1

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.13e-1

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 1

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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bin: 3.75e1
variant carriers: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10398
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

Latino
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allele count: 0
allele frequency: 0.0e0
allele num: 11574
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.056935190793458e-5
allele num: 16510
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66688
num of homozygotes: 0

VQSLOD
type: SiteQuality
SIO_000300: 1.32e-1

MQ
type: SiteQuality
SIO_000300: 6.0e1

ReadPosRankSum
type: SiteQuality
SIO_000300: 6.04e-1

QD
type: SiteQuality
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ClippingRankSum
type: SiteQuality
SIO_000300: 3.13e-1

MQRankSum
type: SiteQuality
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BaseQRankSum
type: SiteQuality
SIO_000300: 6.4e0

FS
type: SiteQuality
SIO_000300: 1.754e0

InbreedingCoeff
type: SiteQuality
SIO_000300: 2.3e-3

DP
type: SiteQuality
SIO_000300: 1.653486e6

GenotypeQuality
all individuals: 7
bin: 3.25e1
variant carriers: 0

GenotypeQuality
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GenotypeQuality
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bin: 2.25e1
variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 11
bin: 4.25e1
variant carriers: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66688
num of homozygotes: 0

East Asian
type: Population
allele count: 1
allele frequency: 1.156336725254394e-4
allele num: 8648
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10398
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11572
num of homozygotes: 0

MQ
type: SiteQuality
SIO_000300: 5.929e1

BaseQRankSum
type: SiteQuality
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FS
type: SiteQuality
SIO_000300: 4.272e0

VQSLOD
type: SiteQuality
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ClippingRankSum
type: SiteQuality
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ReadPosRankSum
type: SiteQuality
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DP
type: SiteQuality
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InbreedingCoeff
type: SiteQuality
SIO_000300: 1.9e-3

MQRankSum
type: SiteQuality
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QD
type: SiteQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 9

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
all individuals: 5136
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GenotypeQuality
all individuals: 4018
bin: 7.25e1
variant carriers: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

African
type: Population
allele count: 1
allele frequency: 9.617234083477592e-5
allele num: 10398
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 8
allele frequency: 1.199580146948568e-4
allele num: 66690
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11574
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16510
num of homozygotes: 0

QD
type: SiteQuality
SIO_000300: 1.463e1

FS
type: SiteQuality
SIO_000300: 5.25e-1

MQRankSum
type: SiteQuality
SIO_000300: 4.48e-1

DP
type: SiteQuality
SIO_000300: 1.654038e6

BaseQRankSum
type: SiteQuality
SIO_000300: 4.44e0

ClippingRankSum
type: SiteQuality
SIO_000300: -3.13e-1

MQ
type: SiteQuality
SIO_000300: 5.964e1

ReadPosRankSum
type: SiteQuality
SIO_000300: 8.21e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: 1.6e-3

VQSLOD
type: SiteQuality
SIO_000300: 3.03e0

GenotypeQuality
all individuals: 5134
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 1
bin: 2.5e0
variant carriers: 0

GenotypeQuality
all individuals: 30471
bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 3601
bin: 8.25e1
variant carriers: 0

GenotypeQuality
all individuals: 9
bin: 7.5e0
variant carriers: 0

GenotypeQuality
all individuals: 16
bin: 4.75e1
variant carriers: 0

GenotypeQuality
all individuals: 8
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 13
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 4
bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 4018
bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1705
bin: 8.75e1
variant carriers: 0

GenotypeQuality
all individuals: 5165
bin: 9.75e1
variant carriers: 2

GenotypeQuality
all individuals: 0
bin: 1.75e1
variant carriers: 0

GenotypeQuality
all individuals: 6
bin: 5.25e1
variant carriers: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.056935190793458e-5
allele num: 16510
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11572
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10398
num of homozygotes: 0

East Asian
type: Population
allele count: 1
allele frequency: 1.156336725254394e-4
allele num: 8648
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66690
num of homozygotes: 0

MQRankSum
type: SiteQuality
SIO_000300: 1.61e-1

BaseQRankSum
type: SiteQuality
SIO_000300: -1.439e0

DP
type: SiteQuality
SIO_000300: 1.653785e6

ReadPosRankSum
type: SiteQuality
SIO_000300: -2.61e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: 1.8e-3

ClippingRankSum
type: SiteQuality
SIO_000300: 1.2e-2

QD
type: SiteQuality
SIO_000300: 1.251e1

VQSLOD
type: SiteQuality
SIO_000300: -1.185e-1

FS
type: SiteQuality
SIO_000300: 9.500999999999999e0

MQ
type: SiteQuality
SIO_000300: 6.0e1

GenotypeQuality
all individuals: 5133
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 13
bin: 3.25e1
variant carriers: 0

GenotypeQuality
all individuals: 9
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 25
bin: 2.25e1
variant carriers: 0

GenotypeQuality
all individuals: 30457
bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 2
bin: 1.75e1
variant carriers: 0

GenotypeQuality
all individuals: 3601
bin: 8.25e1
variant carriers: 0

GenotypeQuality
all individuals: 2
bin: 1.25e1
variant carriers: 0

GenotypeQuality
all individuals: 14
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 7
bin: 7.5e0
variant carriers: 0

GenotypeQuality
all individuals: 5165
bin: 9.75e1
variant carriers: 2

GenotypeQuality
all individuals: 12
bin: 5.25e1
variant carriers: 0

GenotypeQuality
all individuals: 4018
bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 8535
bin: 6.75e1
variant carriers: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11574
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

African
type: Population
allele count: 2
allele frequency: 1.923446816695518e-4
allele num: 10398
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66688
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16510
num of homozygotes: 0

MQRankSum
type: SiteQuality
SIO_000300: 3.73e-1

BaseQRankSum
type: SiteQuality
SIO_000300: 3.98e-1

ClippingRankSum
type: SiteQuality
SIO_000300: -4.41e-1

QD
type: SiteQuality
SIO_000300: 1.283e1

ReadPosRankSum
type: SiteQuality
SIO_000300: -2.04e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: -2.0e-4

DP
type: SiteQuality
SIO_000300: 1.653886e6

VQSLOD
type: SiteQuality
SIO_000300: 9.95e-1

FS
type: SiteQuality
SIO_000300: 2.384e0

MQ
type: SiteQuality
SIO_000300: 6.0e1

GenotypeQuality
all individuals: 16
bin: 3.25e1
variant carriers: 0

GenotypeQuality
all individuals: 5653
bin: 9.75e1
variant carriers: 559

GenotypeQuality
all individuals: 1
bin: 2.5e0
variant carriers: 0

GenotypeQuality
all individuals: 18
bin: 5.25e1
variant carriers: 0

GenotypeQuality
all individuals: 8
bin: 7.5e0
variant carriers: 0

GenotypeQuality
all individuals: 11
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 2
bin: 1.25e1
variant carriers: 0

GenotypeQuality
all individuals: 5078
bin: 7.75e1
variant carriers: 1

GenotypeQuality
all individuals: 8453
bin: 6.75e1
variant carriers: 0

GenotypeQuality
all individuals: 3563
bin: 8.25e1
variant carriers: 0

GenotypeQuality
all individuals: 3976
bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1937
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 26
bin: 2.25e1
variant carriers: 0

GenotypeQuality
all individuals: 10
bin: 3.75e1
variant carriers: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 16
allele frequency: 2.399232245681382e-4
allele num: 66688
num of homozygotes: 0

Other
type: Population
allele count: 1
allele frequency: 1.101321585903084e-3
allele num: 908
num of homozygotes: 0

African
type: Population
allele count: 533
allele frequency: 5.125985766493556e-2
allele num: 10398
num of homozygotes: 11

Latino
type: Population
allele count: 22
allele frequency: 1.901140684410646e-3
allele num: 11572
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16510
num of homozygotes: 0

InbreedingCoeff
type: SiteQuality
SIO_000300: 2.79e-2

MQRankSum
type: SiteQuality
SIO_000300: 2.19e-1

MQ
type: SiteQuality
SIO_000300: 5.972e1

ClippingRankSum
type: SiteQuality
SIO_000300: -5.7e-2

ReadPosRankSum
type: SiteQuality
SIO_000300: 4.72e-1

QD
type: SiteQuality
SIO_000300: 1.475e1

VQSLOD
type: SiteQuality
SIO_000300: 5.31e0

DP
type: SiteQuality
SIO_000300: 1.68464e6

BaseQRankSum
type: SiteQuality
SIO_000300: -1.896e0

FS
type: SiteQuality
SIO_000300: 5.2e-1

GenotypeQuality
all individuals: 9
bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 1969
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 29
bin: 2.25e1
variant carriers: 0

GenotypeQuality
all individuals: 10
bin: 5.25e1
variant carriers: 0

GenotypeQuality
all individuals: 11
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 2
bin: 1.25e1
variant carriers: 0

GenotypeQuality
all individuals: 0
bin: 1.75e1
variant carriers: 0

GenotypeQuality
all individuals: 1709
bin: 8.75e1
variant carriers: 0

GenotypeQuality
all individuals: 12
bin: 5.75e1
variant carriers: 0

GenotypeQuality
all individuals: 3580
bin: 8.25e1
variant carriers: 0

GenotypeQuality
all individuals: 5424
bin: 9.75e1
variant carriers: 3

GenotypeQuality
all individuals: 5100
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 3998
bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 19
bin: 4.75e1
variant carriers: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11572
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 3
allele frequency: 4.498560460652591e-5
allele num: 66688
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10398
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16510
num of homozygotes: 0

FS
type: SiteQuality
SIO_000300: 1.626e0

InbreedingCoeff
type: SiteQuality
SIO_000300: -2.0e-4

MQRankSum
type: SiteQuality
SIO_000300: -7.26e-1

MQ
type: SiteQuality
SIO_000300: 5.783e1

ReadPosRankSum
type: SiteQuality
SIO_000300: 2.95e-1

DP
type: SiteQuality
SIO_000300: 1.664757e6

ClippingRankSum
type: SiteQuality
SIO_000300: 9.08e-1

BaseQRankSum
type: SiteQuality
SIO_000300: 1.05e0

VQSLOD
type: SiteQuality
SIO_000300: 3.37e0

QD
type: SiteQuality
SIO_000300: 1.738e1

GenotypeQuality
all individuals: 0
bin: 1.75e1
variant carriers: 0

GenotypeQuality
all individuals: 11
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 9
bin: 7.5e0
variant carriers: 0

GenotypeQuality
all individuals: 25
bin: 2.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1712
bin: 8.75e1
variant carriers: 0

GenotypeQuality
all individuals: 7
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variant carriers: 0

GenotypeQuality
all individuals: 8502
bin: 6.75e1
variant carriers: 0

GenotypeQuality
all individuals: 10
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variant carriers: 0

GenotypeQuality
all individuals: 4001
bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 18
bin: 3.25e1
variant carriers: 0

GenotypeQuality
all individuals: 5424
bin: 9.75e1
variant carriers: 3

GenotypeQuality
all individuals: 3575
bin: 8.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1968
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 15
bin: 4.75e1
variant carriers: 0

Latino
type: Population
allele count: 3
allele frequency: 2.592464569650881e-4
allele num: 11572
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66684
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16510
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10400
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

MQ
type: SiteQuality
SIO_000300: 5.973e1

VQSLOD
type: SiteQuality
SIO_000300: 8.87e-1

QD
type: SiteQuality
SIO_000300: 1.215e1

MQRankSum
type: SiteQuality
SIO_000300: -6.07e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: 4.8e-3

DP
type: SiteQuality
SIO_000300: 1.66474e6

BaseQRankSum
type: SiteQuality
SIO_000300: -4.999e0

ClippingRankSum
type: SiteQuality
SIO_000300: -4.56e-1

FS
type: SiteQuality
SIO_000300: 0.0e0

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.65e-1

GenotypeQuality
all individuals: 4
bin: 1.25e1
variant carriers: 0

GenotypeQuality
all individuals: 11
bin: 5.75e1
variant carriers: 0

GenotypeQuality
all individuals: 4976
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 1661
bin: 8.75e1
variant carriers: 1

GenotypeQuality
all individuals: 3
bin: 2.5e0
variant carriers: 0

GenotypeQuality
all individuals: 13
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 3899
bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 29552
bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 21
bin: 5.25e1
variant carriers: 1

GenotypeQuality
all individuals: 6745
bin: 9.75e1
variant carriers: 1472

GenotypeQuality
all individuals: 8312
bin: 6.75e1
variant carriers: 0

GenotypeQuality
all individuals: 13
bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 3487
bin: 8.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1917
bin: 9.25e1
variant carriers: 0

South Asian
type: Population
allele count: 378
allele frequency: 2.289521502119927e-2
allele num: 16510
num of homozygotes: 5

African
type: Population
allele count: 22
allele frequency: 2.115384615384615e-3
allele num: 10400
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 25
allele frequency: 3.779860901118839e-3
allele num: 6614
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 944
allele frequency: 1.415716856628674e-2
allele num: 66680
num of homozygotes: 11

East Asian
type: Population
allele count: 1
allele frequency: 1.156336725254394e-4
allele num: 8648
num of homozygotes: 0

Other
type: Population
allele count: 24
allele frequency: 2.643171806167401e-2
allele num: 908
num of homozygotes: 0

Latino
type: Population
allele count: 95
allele frequency: 8.209471137227791e-3
allele num: 11572
num of homozygotes: 0

ReadPosRankSum
type: SiteQuality
SIO_000300: 4.44e-1

VQSLOD
type: SiteQuality
SIO_000300: 6.37e0

DP
type: SiteQuality
SIO_000300: 1.737349e6

MQ
type: SiteQuality
SIO_000300: 5.975e1

MQRankSum
type: SiteQuality
SIO_000300: 1.42e-1

QD
type: SiteQuality
SIO_000300: 1.5e1

FS
type: SiteQuality
SIO_000300: 0.0e0

BaseQRankSum
type: SiteQuality
SIO_000300: 1.79e0

ClippingRankSum
type: SiteQuality
SIO_000300: -1.68e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: 1.62e-2

GenotypeQuality
all individuals: 2
bin: 2.5e0
variant carriers: 0

GenotypeQuality
all individuals: 8
bin: 7.5e0
variant carriers: 0

GenotypeQuality
all individuals: 12
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 19
bin: 3.25e1
variant carriers: 0

GenotypeQuality
all individuals: 3
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variant carriers: 0

GenotypeQuality
all individuals: 18
bin: 5.25e1
variant carriers: 0

GenotypeQuality
all individuals: 6142
bin: 9.75e1
variant carriers: 3

GenotypeQuality
all individuals: 13
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 15
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variant carriers: 0

GenotypeQuality
all individuals: 29798
bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 3939
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variant carriers: 0

GenotypeQuality
all individuals: 5035
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 18
bin: 5.75e1
variant carriers: 0

GenotypeQuality
all individuals: 3557
bin: 8.25e1
variant carriers: 0

African
type: Population
allele count: 1
allele frequency: 9.617234083477592e-5
allele num: 10398
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 2
allele frequency: 2.999130252226854e-5
allele num: 66686
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16510
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11572
num of homozygotes: 0

FS
type: SiteQuality
SIO_000300: 6.429e0

QD
type: SiteQuality
SIO_000300: 1.282e1

ClippingRankSum
type: SiteQuality
SIO_000300: 7.17e-1

ReadPosRankSum
type: SiteQuality
SIO_000300: -2.48e-1

BaseQRankSum
type: SiteQuality
SIO_000300: -4.23e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: 3.0e-3

DP
type: SiteQuality
SIO_000300: 1.694975e6

MQ
type: SiteQuality
SIO_000300: 5.938e1

VQSLOD
type: SiteQuality
SIO_000300: 1.23e0

MQRankSum
type: SiteQuality
SIO_000300: -2.99e-1

GenotypeQuality
all individuals: 3936
bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 2
bin: 1.75e1
variant carriers: 0

GenotypeQuality
all individuals: 8381
bin: 6.75e1
variant carriers: 0

GenotypeQuality
all individuals: 6162
bin: 9.75e1
variant carriers: 23

GenotypeQuality
all individuals: 2
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variant carriers: 0

GenotypeQuality
all individuals: 1708
bin: 8.75e1
variant carriers: 0

GenotypeQuality
all individuals: 25
bin: 2.25e1
variant carriers: 0

GenotypeQuality
all individuals: 12
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 5030
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 8
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variant carriers: 0

GenotypeQuality
all individuals: 1988
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 15
bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 26
bin: 5.75e1
variant carriers: 0

GenotypeQuality
all individuals: 20
bin: 5.25e1
variant carriers: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 16
allele frequency: 2.399304201781483e-4
allele num: 66686
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11574
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10398
num of homozygotes: 0

South Asian
type: Population
allele count: 7
allele frequency: 4.239854633555421e-4
allele num: 16510
num of homozygotes: 0

MQ
type: SiteQuality
SIO_000300: 6.0e1

VQSLOD
type: SiteQuality
SIO_000300: 2.08e0

ReadPosRankSum
type: SiteQuality
SIO_000300: 2.57e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: 1.8e-3

QD
type: SiteQuality
SIO_000300: 1.344e1

FS
type: SiteQuality
SIO_000300: 1.729e0

BaseQRankSum
type: SiteQuality
SIO_000300: -5.9e-1

ClippingRankSum
type: SiteQuality
SIO_000300: -3.9e-1

MQRankSum
type: SiteQuality
SIO_000300: -2.21e-1

DP
type: SiteQuality
SIO_000300: 1.696149e6

GenotypeQuality
all individuals: 1710
bin: 8.75e1
variant carriers: 0

GenotypeQuality
all individuals: 2
bin: 2.5e0
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10398
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16510
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11574
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 1
allele frequency: 1.511944360447536e-4
allele num: 6614
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 16
allele frequency: 2.399376162197828e-4
allele num: 66684
num of homozygotes: 0

ClippingRankSum
type: SiteQuality
SIO_000300: -2.36e-1

MQ
type: SiteQuality
SIO_000300: 5.974e1

VQSLOD
type: SiteQuality
SIO_000300: 5.56e0

FS
type: SiteQuality
SIO_000300: 0.0e0

DP
type: SiteQuality
SIO_000300: 1.696501e6

ReadPosRankSum
type: SiteQuality
SIO_000300: 3.97e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: -3.0e-4

BaseQRankSum
type: SiteQuality
SIO_000300: -1.924e0

MQRankSum
type: SiteQuality
SIO_000300: 1.55e-1

QD
type: SiteQuality
SIO_000300: 1.338e1

GenotypeQuality
all individuals: 8
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
all individuals: 6194
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variant carriers: 25

GenotypeQuality
all individuals: 3561
bin: 8.25e1
variant carriers: 0

East Asian
type: Population
allele count: 24
allele frequency: 2.775208140610546e-3
allele num: 8648
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11572
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10398
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66682
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.056935190793458e-5
allele num: 16510
num of homozygotes: 0

FS
type: SiteQuality
SIO_000300: 1.115e0

DP
type: SiteQuality
SIO_000300: 1.697716e6

BaseQRankSum
type: SiteQuality
SIO_000300: -4.232e0

MQRankSum
type: SiteQuality
SIO_000300: 1.98e-1

VQSLOD
type: SiteQuality
SIO_000300: 4.11e0

ClippingRankSum
type: SiteQuality
SIO_000300: -1.75e-1

ReadPosRankSum
type: SiteQuality
SIO_000300: 3.88e-1

MQ
type: SiteQuality
SIO_000300: 5.962e1

InbreedingCoeff
type: SiteQuality
SIO_000300: -4.0e-4

QD
type: SiteQuality
SIO_000300: 1.256e1

GenotypeQuality
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bin: 1.75e1
variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 8.75e1
variant carriers: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.499565126113427e-5
allele num: 66686
num of homozygotes: 0

Latino
type: Population
allele count: 3
allele frequency: 2.592912705272256e-4
allele num: 11570
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 908
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10398
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

South Asian
type: Population
allele count: 41
allele frequency: 2.483343428225318e-3
allele num: 16510
num of homozygotes: 1

ClippingRankSum
type: SiteQuality
SIO_000300: 1.18e-1

FS
type: SiteQuality
SIO_000300: 3.275e0

DP
type: SiteQuality
SIO_000300: 1.697724e6

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.33e-1

MQ
type: SiteQuality
SIO_000300: 5.974e1

MQRankSum
type: SiteQuality
SIO_000300: 2.94e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: 1.9e-2

VQSLOD
type: SiteQuality
SIO_000300: 9.18e-1

QD
type: SiteQuality
SIO_000300: 1.433e1

BaseQRankSum
type: SiteQuality
SIO_000300: -4.279e0

GenotypeQuality
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bin: 7.5e0
variant carriers: 0

GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
all individuals: 20
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GenotypeQuality
all individuals: 1992
bin: 9.25e1
variant carriers: 0

Other
type: Population
allele count: 1
allele frequency: 1.103752759381898e-3
allele num: 906
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16508
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11574
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8646
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10398
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66682
num of homozygotes: 0

ReadPosRankSum
type: SiteQuality
SIO_000300: 5.78e-1

MQ
type: SiteQuality
SIO_000300: 5.963e1

VQSLOD
type: SiteQuality
SIO_000300: 2.19e-1

MQRankSum
type: SiteQuality
SIO_000300: 6.21e-1

QD
type: SiteQuality
SIO_000300: 1.312e1

DP
type: SiteQuality
SIO_000300: 1.696327e6

FS
type: SiteQuality
SIO_000300: 8.643000000000001e0

BaseQRankSum
type: SiteQuality
SIO_000300: -5.22e-1

ClippingRankSum
type: SiteQuality
SIO_000300: -3.39e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: -2.0e-4

GenotypeQuality
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bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 16
bin: 3.25e1
variant carriers: 0

GenotypeQuality
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bin: 1.25e1
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
all individuals: 2
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GenotypeQuality
all individuals: 12
bin: 4.25e1
variant carriers: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10398
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 906
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11574
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 2
allele frequency: 2.999310158663508e-5
allele num: 66682
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.25e0

MQ
type: SiteQuality
SIO_000300: 6.0e1

InbreedingCoeff
type: SiteQuality
SIO_000300: -2.0e-4

BaseQRankSum
type: SiteQuality
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QD
type: SiteQuality
SIO_000300: 1.297e1

VQSLOD
type: SiteQuality
SIO_000300: 8.82e-1

FS
type: SiteQuality
SIO_000300: 1.368e0

ClippingRankSum
type: SiteQuality
SIO_000300: 6.4e-1

MQRankSum
type: SiteQuality
SIO_000300: 6.77e-1

DP
type: SiteQuality
SIO_000300: 1.696466e6

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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bin: 6.75e1
variant carriers: 0

Latino
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allele count: 0
allele frequency: 0.0e0
allele num: 11572
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10398
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.499745043342632e-5
allele num: 66678
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 906
num of homozygotes: 0

South Asian
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allele count: 0
allele frequency: 0.0e0
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InbreedingCoeff
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VQSLOD
type: SiteQuality
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ClippingRankSum
type: SiteQuality
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ReadPosRankSum
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FS
type: SiteQuality
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MQRankSum
type: SiteQuality
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QD
type: SiteQuality
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MQ
type: SiteQuality
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BaseQRankSum
type: SiteQuality
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DP
type: SiteQuality
SIO_000300: 1.696595e6

GenotypeQuality
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bin: 7.25e1
variant carriers: 0

GenotypeQuality
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bin: 2.25e1
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 9.75e1
variant carriers: 2

East Asian
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allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10398
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 906
num of homozygotes: 0

Latino
type: Population
allele count: 2
allele frequency: 1.728011059270779e-4
allele num: 11574
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16510
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

BaseQRankSum
type: SiteQuality
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FS
type: SiteQuality
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ClippingRankSum
type: SiteQuality
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QD
type: SiteQuality
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MQRankSum
type: SiteQuality
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VQSLOD
type: SiteQuality
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InbreedingCoeff
type: SiteQuality
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ReadPosRankSum
type: SiteQuality
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MQ
type: SiteQuality
SIO_000300: 6.028e1

DP
type: SiteQuality
SIO_000300: 1.697084e6

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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bin: 4.25e1
variant carriers: 0

Latino
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allele count: 0
allele frequency: 0.0e0
allele num: 11574
num of homozygotes: 0

European (Non-Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 66676
num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
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Other
type: Population
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South Asian
type: Population
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allele frequency: 6.056935190793458e-5
allele num: 16510
num of homozygotes: 0

East Asian
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ReadPosRankSum
type: SiteQuality
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DP
type: SiteQuality
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MQ
type: SiteQuality
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ClippingRankSum
type: SiteQuality
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BaseQRankSum
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InbreedingCoeff
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FS
type: SiteQuality
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VQSLOD
type: SiteQuality
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MQRankSum
type: SiteQuality
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QD
type: SiteQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 4.75e1
variant carriers: 0

African
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allele frequency: 0.0e0
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num of homozygotes: 0

Other
type: Population
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allele frequency: 0.0e0
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num of homozygotes: 0

Latino
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allele frequency: 0.0e0
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num of homozygotes: 0

South Asian
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allele frequency: 0.0e0
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num of homozygotes: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

European (Non-Finnish)
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allele count: 4
allele frequency: 5.998980173370527e-5
allele num: 66678
num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

BaseQRankSum
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MQ
type: SiteQuality
SIO_000300: 6.0e1

FS
type: SiteQuality
SIO_000300: 4.5e0

DP
type: SiteQuality
SIO_000300: 1.697411e6

MQRankSum
type: SiteQuality
SIO_000300: -7.3e-2

ClippingRankSum
type: SiteQuality
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VQSLOD
type: SiteQuality
SIO_000300: 9.83e-1

InbreedingCoeff
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SIO_000300: 3.0e-4

QD
type: SiteQuality
SIO_000300: 1.433e1

ReadPosRankSum
type: SiteQuality
SIO_000300: 7.21e-1

GenotypeQuality
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bin: 3.25e1
variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 9.75e1
variant carriers: 1

GenotypeQuality
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bin: 4.25e1
variant carriers: 0

Latino
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allele count: 0
allele frequency: 0.0e0
allele num: 11574
num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

European (Non-Finnish)
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allele count: 1
allele frequency: 1.499745043342632e-5
allele num: 66678
num of homozygotes: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

South Asian
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allele frequency: 0.0e0
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num of homozygotes: 0

Other
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allele frequency: 0.0e0
allele num: 906
num of homozygotes: 0

African
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

MQ
type: SiteQuality
SIO_000300: 6.0e1

ClippingRankSum
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SIO_000300: -5.580000000000001e-1

ReadPosRankSum
type: SiteQuality
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DP
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VQSLOD
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SIO_000300: 9.83e-1

MQRankSum
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SIO_000300: -7.3e-2

InbreedingCoeff
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SIO_000300: 3.0e-4

BaseQRankSum
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QD
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FS
type: SiteQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

African
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allele frequency: 0.0e0
allele num: 10398
num of homozygotes: 0

Latino
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allele frequency: 0.0e0
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num of homozygotes: 0

South Asian
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allele frequency: 0.0e0
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num of homozygotes: 0

Other
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allele frequency: 0.0e0
allele num: 906
num of homozygotes: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

European (Non-Finnish)
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allele count: 1
allele frequency: 1.499700059988002e-5
allele num: 66680
num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

MQRankSum
type: SiteQuality
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BaseQRankSum
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MQ
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DP
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VQSLOD
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InbreedingCoeff
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SIO_000300: -1.0e-4

ReadPosRankSum
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FS
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QD
type: SiteQuality
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ClippingRankSum
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SIO_000300: -8.159999999999999e-1

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

South Asian
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allele count: 0
allele frequency: 0.0e0
allele num: 16510
num of homozygotes: 0

Latino
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allele frequency: 0.0e0
allele num: 11574
num of homozygotes: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

European (Finnish)
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allele frequency: 0.0e0
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European (Non-Finnish)
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allele count: 1
allele frequency: 1.499745043342632e-5
allele num: 66678
num of homozygotes: 0

African
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Other
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num of homozygotes: 0

QD
type: SiteQuality
SIO_000300: 1.094e1

ClippingRankSum
type: SiteQuality
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FS
type: SiteQuality
SIO_000300: 4.424e0

ReadPosRankSum
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DP
type: SiteQuality
SIO_000300: 1.697554e6

InbreedingCoeff
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SIO_000300: -1.0e-4

MQRankSum
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VQSLOD
type: SiteQuality
SIO_000300: 4.24e-1

BaseQRankSum
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SIO_000300: 4.04e0

MQ
type: SiteQuality
SIO_000300: 5.945e1

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 7.75e1
variant carriers: 0

South Asian
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allele frequency: 0.0e0
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num of homozygotes: 0

Latino
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allele frequency: 8.640055296353897e-5
allele num: 11574
num of homozygotes: 0

African
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

European (Non-Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 66682
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

MQRankSum
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FS
type: SiteQuality
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QD
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ClippingRankSum
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BaseQRankSum
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VQSLOD
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InbreedingCoeff
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ReadPosRankSum
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SIO_000300: 1.45e0

MQ
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DP
type: SiteQuality
SIO_000300: 1.697773e6

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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bin: 4.75e1
variant carriers: 0

European (Finnish)
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allele frequency: 0.0e0
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num of homozygotes: 0

Latino
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allele frequency: 0.0e0
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African
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South Asian
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European (Non-Finnish)
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allele frequency: 0.0e0
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East Asian
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Other
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DP
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ReadPosRankSum
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BaseQRankSum
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MQRankSum
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ClippingRankSum
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QD
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MQ
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InbreedingCoeff
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FS
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VQSLOD
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 8.75e1
variant carriers: 0

European (Non-Finnish)
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allele frequency: 0.0e0
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num of homozygotes: 0

African
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East Asian
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European (Finnish)
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num of homozygotes: 0

Latino
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South Asian
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Other
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FS
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DP
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MQ
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ReadPosRankSum
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BaseQRankSum
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MQRankSum
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InbreedingCoeff
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VQSLOD
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QD
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ClippingRankSum
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

European (Non-Finnish)
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Latino
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Other
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East Asian
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African
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South Asian
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European (Finnish)
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MQ
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FS
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MQRankSum
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QD
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ClippingRankSum
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DP
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InbreedingCoeff
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BaseQRankSum
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VQSLOD
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ReadPosRankSum
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

African
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Latino
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European (Non-Finnish)
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East Asian
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European (Finnish)
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South Asian
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Other
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MQ
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QD
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ReadPosRankSum
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MQRankSum
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FS
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BaseQRankSum
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ClippingRankSum
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VQSLOD
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InbreedingCoeff
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DP
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
all individuals: 3
bin: 5.75e1
variant carriers: 0

European (Non-Finnish)
type: Population
allele count: 6
allele frequency: 8.997120921305183e-5
allele num: 66688
num of homozygotes: 0

Other
type: Population
allele count: 1
allele frequency: 1.103752759381898e-3
allele num: 906
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10400
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 1
allele frequency: 1.511944360447536e-4
allele num: 6614
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11576
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16510
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

DP
type: SiteQuality
SIO_000300: 1.698668e6

MQRankSum
type: SiteQuality
SIO_000300: 1.02e-1

MQ
type: SiteQuality
SIO_000300: 5.985e1

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.2e0

BaseQRankSum
type: SiteQuality
SIO_000300: 1.57e0

ClippingRankSum
type: SiteQuality
SIO_000300: -1.114e0

VQSLOD
type: SiteQuality
SIO_000300: 3.06e0

FS
type: SiteQuality
SIO_000300: 0.0e0

QD
type: SiteQuality
SIO_000300: 1.472e1

InbreedingCoeff
type: SiteQuality
SIO_000300: -2.0e-4

GenotypeQuality
all individuals: 8396
bin: 6.75e1
variant carriers: 0

GenotypeQuality
all individuals: 11
bin: 5.25e1
variant carriers: 0

GenotypeQuality
all individuals: 4
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 6
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 4
bin: 7.5e0
variant carriers: 0

GenotypeQuality
all individuals: 6191
bin: 9.75e1
variant carriers: 1

GenotypeQuality
all individuals: 26
bin: 2.25e1
variant carriers: 0

GenotypeQuality
all individuals: 7
bin: 3.25e1
variant carriers: 0

GenotypeQuality
all individuals: 7
bin: 4.75e1
variant carriers: 0

GenotypeQuality
all individuals: 29754
bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 3578
bin: 8.25e1
variant carriers: 0

GenotypeQuality
all individuals: 2002
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 3
bin: 5.75e1
variant carriers: 0

GenotypeQuality
all individuals: 3955
bin: 7.25e1
variant carriers: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10400
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 906
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11576
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.056935190793458e-5
allele num: 16510
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66688
num of homozygotes: 0

BaseQRankSum
type: SiteQuality
SIO_000300: -1.503e0

MQRankSum
type: SiteQuality
SIO_000300: 2.08e0

ClippingRankSum
type: SiteQuality
SIO_000300: 1.37e0

VQSLOD
type: SiteQuality
SIO_000300: -1.392e0

InbreedingCoeff
type: SiteQuality
SIO_000300: -1.0e-4

DP
type: SiteQuality
SIO_000300: 1.698429e6

FS
type: SiteQuality
SIO_000300: 2.337e0

MQ
type: SiteQuality
SIO_000300: 5.967e1

ReadPosRankSum
type: SiteQuality
SIO_000300: -1.421e0

QD
type: SiteQuality
SIO_000300: 1.206e1

GenotypeQuality
all individuals: 5
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 6
bin: 5.75e1
variant carriers: 0

GenotypeQuality
all individuals: 3
bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 2
bin: 1.25e1
variant carriers: 0

GenotypeQuality
all individuals: 3955
bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 3577
bin: 8.25e1
variant carriers: 0

GenotypeQuality
all individuals: 5028
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 8397
bin: 6.75e1
variant carriers: 0

GenotypeQuality
all individuals: 2002
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 2
bin: 2.5e0
variant carriers: 0

GenotypeQuality
all individuals: 6
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 29752
bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 6192
bin: 9.75e1
variant carriers: 1

GenotypeQuality
all individuals: 9
bin: 5.25e1
variant carriers: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 906
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66688
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.056935190793458e-5
allele num: 16510
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10400
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11574
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

InbreedingCoeff
type: SiteQuality
SIO_000300: 3.0e-4

FS
type: SiteQuality
SIO_000300: 0.0e0

QD
type: SiteQuality
SIO_000300: 9.24e0

BaseQRankSum
type: SiteQuality
SIO_000300: -4.956e0

DP
type: SiteQuality
SIO_000300: 1.698589e6

ClippingRankSum
type: SiteQuality
SIO_000300: -1.24e0

ReadPosRankSum
type: SiteQuality
SIO_000300: 3.47e-1

VQSLOD
type: SiteQuality
SIO_000300: -8.643999999999999e-1

MQRankSum
type: SiteQuality
SIO_000300: -7.98e-1

MQ
type: SiteQuality
SIO_000300: 5.892e1

GenotypeQuality
all individuals: 5
bin: 5.75e1
variant carriers: 0

GenotypeQuality
all individuals: 5
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 6
bin: 3.25e1
variant carriers: 0

GenotypeQuality
all individuals: 3
bin: 7.5e0
variant carriers: 0

GenotypeQuality
all individuals: 7
bin: 5.25e1
variant carriers: 0

GenotypeQuality
all individuals: 25
bin: 2.25e1
variant carriers: 0

GenotypeQuality
all individuals: 6
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 3955
bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 2
bin: 2.5e0
variant carriers: 0

GenotypeQuality
all individuals: 3578
bin: 8.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1
bin: 1.75e1
variant carriers: 0

GenotypeQuality
all individuals: 6192
bin: 9.75e1
variant carriers: 1

GenotypeQuality
all individuals: 1715
bin: 8.75e1
variant carriers: 0

GenotypeQuality
all individuals: 8399
bin: 6.75e1
variant carriers: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16510
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 906
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6614
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8648
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10400
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11576
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.49947518368571e-5
allele num: 66690
num of homozygotes: 0

DP
type: SiteQuality
SIO_000300: 1.698564e6

BaseQRankSum
type: SiteQuality
SIO_000300: 3.28e0

MQRankSum
type: SiteQuality
SIO_000300: -9.48e-1

QD
type: SiteQuality
SIO_000300: 1.079e1

ReadPosRankSum
type: SiteQuality
SIO_000300: 2.16e0

FS
type: SiteQuality
SIO_000300: 3.454e0

InbreedingCoeff
type: SiteQuality
SIO_000300: 5.0e-4

VQSLOD
type: SiteQuality
SIO_000300: -9.585e-1

ClippingRankSum
type: SiteQuality
SIO_000300: -1.94e0

MQ
type: SiteQuality
SIO_000300: 5.913e1