22-22316939-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22316939
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22316939
    reference: chr 22
allele count: 1
allele frequency: 8.342092530490349e-6
allele num: 119874
alternate allele: A
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1387C>T
  hgvsp: ENST00000398793.2:c.1387C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.185C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1387C>T
  hgvsp: ENST00000357179.5:c.1387C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.771C>T
  hgvsp: ENST00000457270.1:c.771C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.574C>T
  hgvsp: ENST00000413067.2:c.574C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1223C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1079C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*203C>T
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 39075
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1537
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 109
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 113
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 268
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1156
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 610
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3788
  bin: 3.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 52
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13298
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 616
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 371
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 16
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 135
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 30
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 122
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 343
  bin: 5.25e1
  variant carriers: 0
hgvs: p.Leu463Leu
num of homozygotes: 0
population: Latino
population: Other
population: European (Non-Finnish)
population: European (Finnish)
population: African
population: East Asian
population: South Asian
reference allele: G
site quality: FS
site quality: QD
site quality: MQ
site quality: InbreedingCoeff
site quality: DP
site quality: ReadPosRankSum
site quality: ClippingRankSum
site quality: MQRankSum
site quality: BaseQRankSum
site quality: VQSLOD

22-22316943-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22316943
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22316943
    reference: chr 22
allele count: 2
allele frequency: 1.670425123193853e-5
allele num: 119730
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.181G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1219G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1383G>A
  hgvsp: ENST00000357179.5:c.1383G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1075G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.767G>A
  hgvsp: ENST00000457270.1:c.767G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.570G>A
  hgvsp: ENST00000413067.2:c.570G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1383G>A
  hgvsp: ENST00000398793.2:c.1383G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*199G>A
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 113
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1444
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 52
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 130
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 269
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1779
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 38545
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13198
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3798
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 653
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 640
  bin: 3.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1040
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1618
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 479
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 42576
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 34
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 549
  bin: 9.75e1
  variant carriers: 2
hgvs: p.Val461Val
num of homozygotes: 0
population: African
population: European (Non-Finnish)
population: East Asian
population: European (Finnish)
population: South Asian
population: Other
population: Latino
reference allele: C
site quality: MQRankSum
site quality: QD
site quality: InbreedingCoeff
site quality: FS
site quality: DP
site quality: BaseQRankSum
site quality: VQSLOD
site quality: ReadPosRankSum
site quality: MQ
site quality: ClippingRankSum

22-22316945-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22316945
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22316945
    reference: chr 22
allele count: 8
allele frequency: 6.684491978609626e-5
allele num: 119680
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1381G>A
  hgvsp: ENSP00000349705.5:p.Val461Met
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.765G>A
  hgvsp: ENSP00000408282.1:p.Val256Met
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1217G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.179G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1381G>A
  hgvsp: ENSP00000381773.2:p.Val461Met
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*197G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1073G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.568G>A
  hgvsp: ENSP00000393118.2:p.Val190Met
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 1421
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 53
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 116
  bin: 4.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1778
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 272
  bin: 4.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 662
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 129
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 635
  bin: 3.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 38510
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3809
  bin: 3.25e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 13236
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 42959
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 243
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 333
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 198
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 612
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1954
  bin: 7.75e1
  variant carriers: 0
hgvs: p.Val461Met
num of homozygotes: 0
population: African
population: East Asian
population: Other
population: Latino
population: European (Finnish)
population: South Asian
population: European (Non-Finnish)
reference allele: C
site quality: MQRankSum
site quality: BaseQRankSum
site quality: VQSLOD
site quality: ClippingRankSum
site quality: FS
site quality: InbreedingCoeff
site quality: MQ
site quality: QD
site quality: DP
site quality: ReadPosRankSum

22-22316959-A-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22316959
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22316959
    reference: chr 22
allele count: 1
allele frequency: 8.378577652657685e-6
allele num: 119352
alternate allele: G
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1367T>C
  hgvsp: ENSP00000381773.2:p.Met456Thr
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1203T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.165T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1059T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1367T>C
  hgvsp: ENSP00000349705.5:p.Met456Thr
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.751T>C
  hgvsp: ENSP00000408282.1:p.Met251Thr
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*183T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.554T>C
  hgvsp: ENSP00000393118.2:p.Met185Thr
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 175
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 645
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 36318
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2611
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2554
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 271
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13245
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 792
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 115
  bin: 4.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 52
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3838
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2262
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 385
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 204
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 634
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 958
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 56
  bin: 1.25e1
  variant carriers: 0
hgvs: p.Met456Thr
num of homozygotes: 0
population: Latino
population: East Asian
population: South Asian
population: African
population: Other
population: European (Finnish)
population: European (Non-Finnish)
reference allele: A
site quality: ClippingRankSum
site quality: InbreedingCoeff
site quality: MQRankSum
site quality: MQ
site quality: DP
site quality: FS
site quality: ReadPosRankSum
site quality: VQSLOD
site quality: QD
site quality: BaseQRankSum

22-22316960-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22316960
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22316960
    reference: chr 22
allele count: 1
allele frequency: 8.385884878572387e-6
allele num: 119248
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1202A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1058A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1366A>G
  hgvsp: ENSP00000381773.2:p.Met456Val
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.164A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.750A>G
  hgvsp: ENSP00000408282.1:p.Met251Val
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.553A>G
  hgvsp: ENSP00000393118.2:p.Met185Val
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1366A>G
  hgvsp: ENSP00000349705.5:p.Met456Val
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*182A>G
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: missense
filter: VQSRTrancheSNP99.60to99.80
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 183
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 116
  bin: 4.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 3860
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13143
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2777
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2916
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 52
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 270
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 35826
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 818
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 654
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 546
  bin: 9.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 510
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 70
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1303
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1041
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 213
  bin: 7.5e0
  variant carriers: 0
hgvs: p.Met456Val
num of homozygotes: 0
population: European (Non-Finnish)
population: South Asian
population: Other
population: Latino
population: European (Finnish)
population: African
population: East Asian
reference allele: T
site quality: QD
site quality: BaseQRankSum
site quality: FS
site quality: ReadPosRankSum
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: VQSLOD
site quality: ClippingRankSum
site quality: DP
site quality: MQ

22-22316964-C-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22316964
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22316964
    reference: chr 22
allele count: 1
allele frequency: 8.3948959032908e-6
allele num: 119120
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*178G>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1362G>C
  hgvsp: ENSP00000381773.2:p.Glu454Asp
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.549G>C
  hgvsp: ENSP00000393118.2:p.Glu183Asp
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1362G>C
  hgvsp: ENSP00000349705.5:p.Glu454Asp
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.160G>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1198G>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.746G>C
  hgvsp: ENSP00000408282.1:p.Glu249Asp
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1054G>C
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 198
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3249
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 275
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13186
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 52
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 115
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 652
  bin: 3.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 857
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3876
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2941
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 35213
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 115
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2038
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 339
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1045
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 83
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1163
  bin: 3.75e1
  variant carriers: 0
hgvs: p.Glu454Asp
num of homozygotes: 0
population: Other
population: East Asian
population: South Asian
population: European (Non-Finnish)
population: Latino
population: African
population: European (Finnish)
reference allele: C
site quality: ClippingRankSum
site quality: ReadPosRankSum
site quality: VQSLOD
site quality: MQ
site quality: FS
site quality: DP
site quality: InbreedingCoeff
site quality: MQRankSum
site quality: BaseQRankSum
site quality: QD

22-22316964-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22316964
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22316964
    reference: chr 22
allele count: 2
allele frequency: 1.67897918065816e-5
allele num: 119120
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*178G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1054G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.160G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1198G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1362G>A
  hgvsp: ENST00000357179.5:c.1362G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.549G>A
  hgvsp: ENST00000413067.2:c.549G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1362G>A
  hgvsp: ENST00000398793.2:c.1362G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.746G>A
  hgvsp: ENST00000457270.1:c.746G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 652
  bin: 3.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 3876
  bin: 3.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 115
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 857
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2941
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 275
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13186
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 35213
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3249
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 198
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 52
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1154
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1163
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1005
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 595
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 83
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1423
  bin: 3.25e1
  variant carriers: 0
hgvs: p.Glu454Glu
num of homozygotes: 0
population: Latino
population: East Asian
population: European (Finnish)
population: Other
population: European (Non-Finnish)
population: African
population: South Asian
reference allele: C
site quality: FS
site quality: MQRankSum
site quality: QD
site quality: ReadPosRankSum
site quality: MQ
site quality: VQSLOD
site quality: ClippingRankSum
site quality: DP
site quality: InbreedingCoeff
site quality: BaseQRankSum

22-22316970-G-GA
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22316970
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22316971
    reference: chr 22
allele count: 1
allele frequency: 8.413825598223e-6
allele num: 118852
alternate allele: GA
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1047dupT
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.153dupT
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*171dupT
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: frameshift_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1355dupT
  hgvsp: ENSP00000349705.5:p.Thr453HisfsTer22
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: frameshift_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.739dupT
  hgvsp: ENSP00000408282.1:p.Thr248HisfsTer22
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: frameshift_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.542dupT
  hgvsp: ENSP00000393118.2:p.Thr182HisfsTer22
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1191dupT
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: frameshift_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1355dupT
  hgvsp: ENSP00000381773.2:p.Thr453HisfsTer22
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: frameshift
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 116
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 285
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3822
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3214
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 216
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34282
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3917
  bin: 3.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 955
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13089
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 52
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 662
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1037
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2003
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 553
  bin: 9.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 2647
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1323
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 170
  bin: 1.75e1
  variant carriers: 0
hgvs: p.Thr453HisfsTer22
num of homozygotes: 0
population: Latino
population: European (Non-Finnish)
population: African
population: East Asian
population: South Asian
population: European (Finnish)
population: Other
reference allele: G
site quality: QD
site quality: BaseQRankSum
site quality: VQSLOD
site quality: MQRankSum
site quality: DP
site quality: FS
site quality: MQ
site quality: ClippingRankSum
site quality: InbreedingCoeff
site quality: ReadPosRankSum

22-22316977-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22316977
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22316977
    reference: chr 22
allele count: 1
allele frequency: 8.430281571404485e-6
allele num: 118620
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*168-3C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1044-3C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1352-3C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.539-3C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.150-3C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.736-3C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1352-3C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1185C>T
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: splice region
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 1021
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3507
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 33270
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4013
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4473
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 52
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12961
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 287
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 118
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 6.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 674
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 231
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2878
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 558
  bin: 9.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 1500
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 344
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 434
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1627
  bin: 3.75e1
  variant carriers: 0
hgvs: c.1352-3C>T
num of homozygotes: 0
population: European (Finnish)
population: African
population: South Asian
population: European (Non-Finnish)
population: East Asian
population: Latino
population: Other
reference allele: G
site quality: InbreedingCoeff
site quality: MQ
site quality: ClippingRankSum
site quality: BaseQRankSum
site quality: ReadPosRankSum
site quality: DP
site quality: VQSLOD
site quality: FS
site quality: MQRankSum
site quality: QD

22-22316982-G-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22316982
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22316982
    reference: chr 22
allele count: 1
allele frequency: 8.455658526686058e-6
allele num: 118264
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1352-8C>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1044-8C>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1352-8C>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*168-8C>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.150-8C>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.539-8C>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.736-8C>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1180C>G
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: splice region
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 1116
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3665
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 52
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 246
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32370
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4066
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 707
  bin: 3.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 5106
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 301
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12850
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 123
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6217
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1671
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1080
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2132
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 313
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1641
  bin: 5.25e1
  variant carriers: 0
hgvs: c.1352-8C>G
num of homozygotes: 0
population: African
population: European (Finnish)
population: Latino
population: European (Non-Finnish)
population: East Asian
population: Other
population: South Asian
reference allele: G
site quality: ReadPosRankSum
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: FS
site quality: QD
site quality: DP
site quality: ClippingRankSum
site quality: VQSLOD
site quality: BaseQRankSum
site quality: MQ

22-22316984-T-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22316984
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22316984
    reference: chr 22
allele count: 151
allele frequency: 1.276696484434449e-3
allele num: 118274
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.150-10A>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*168-10A>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1352-10A>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.736-10A>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.539-10A>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1178A>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1044-10A>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1352-10A>C
  variant of: http://identifiers.org/hgnc/11993
canonical: false
consequence: 3' UTR
filter: VQSRTrancheSNP99.60to99.80
genotype depth: GenotypeDepth
  all individuals: 12853
  bin: 2.75e1
  variant carriers: 26
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5098
  bin: 1.75e1
  variant carriers: 19
genotype depth: GenotypeDepth
  all individuals: 54
  bin: 5.25e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32317
  bin: 2.25e1
  variant carriers: 31
genotype depth: GenotypeDepth
  all individuals: 722
  bin: 3.75e1
  variant carriers: 20
genotype depth: GenotypeDepth
  all individuals: 3668
  bin: 1.25e1
  variant carriers: 11
genotype depth: GenotypeDepth
  all individuals: 24
  bin: 5.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 252
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 6.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 123
  bin: 4.75e1
  variant carriers: 6
genotype depth: GenotypeDepth
  all individuals: 1140
  bin: 7.5e0
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 310
  bin: 4.25e1
  variant carriers: 10
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4062
  bin: 3.25e1
  variant carriers: 19
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 6.25e1
  variant carriers: 3
genotype quality: GenotypeQuality
  all individuals: 2123
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 54
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1601
  bin: 4.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 2901
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 161
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1059
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2164
  bin: 7.25e1
  variant carriers: 0
num of homozygotes: 0
population: South Asian
population: European (Non-Finnish)
population: African
population: East Asian
population: Other
population: Latino
population: European (Finnish)
reference allele: T
site quality: VQSLOD
site quality: ReadPosRankSum
site quality: FS
site quality: MQRankSum
site quality: DP
site quality: MQ
site quality: QD
site quality: InbreedingCoeff
site quality: BaseQRankSum
site quality: ClippingRankSum

22-22316986-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22316986
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22316986
    reference: chr 22
allele count: 4
allele frequency: 3.38409475465313e-5
allele num: 118200
alternate allele: C
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1352-12A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1352-12A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1176A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.150-12A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*168-12A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.736-12A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.539-12A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1044-12A>G
  variant of: http://identifiers.org/hgnc/11993
canonical: false
consequence: 3' UTR
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 310
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12889
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3678
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1176
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32168
  bin: 2.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 121
  bin: 4.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 4067
  bin: 3.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 741
  bin: 3.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5133
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 263
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 53
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1141
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2906
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 272
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 47
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 439
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1496
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 319
  bin: 7.5e0
  variant carriers: 0
num of homozygotes: 0
population: European (Non-Finnish)
population: Latino
population: African
population: Other
population: South Asian
population: East Asian
population: European (Finnish)
reference allele: T
site quality: DP
site quality: MQRankSum
site quality: BaseQRankSum
site quality: InbreedingCoeff
site quality: FS
site quality: VQSLOD
site quality: ClippingRankSum
site quality: QD
site quality: ReadPosRankSum
site quality: MQ

22-22316988-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22316988
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22316988
    reference: chr 22
allele count: 4
allele frequency: 3.397777853283952e-5
allele num: 117724
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1352-14G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.736-14G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*168-14G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.539-14G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1174G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1044-14G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.150-14G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1352-14G>A
  variant of: http://identifiers.org/hgnc/11993
canonical: false
consequence: 3' UTR
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 264
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 54
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3674
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1208
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 129
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 802
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12983
  bin: 2.75e1
  variant carriers: 4
genotype depth: GenotypeDepth
  all individuals: 5207
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 342
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31509
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4426
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2114
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1147
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1787
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2230
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 584
  bin: 9.75e1
  variant carriers: 4
genotype quality: GenotypeQuality
  all individuals: 6208
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1719
  bin: 2.75e1
  variant carriers: 0
num of homozygotes: 0
population: South Asian
population: East Asian
population: Other
population: European (Non-Finnish)
population: African
population: Latino
population: European (Finnish)
reference allele: C
site quality: DP
site quality: BaseQRankSum
site quality: ReadPosRankSum
site quality: InbreedingCoeff
site quality: VQSLOD
site quality: FS
site quality: ClippingRankSum
site quality: MQ
site quality: MQRankSum
site quality: QD

22-22316989-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22316989
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22316989
    reference: chr 22
allele count: 19
allele frequency: 1.610852055955914e-4
allele num: 117950
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.539-15C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.736-15C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.150-15C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1352-15C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1352-15C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*168-15C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1173C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1044-15C>T
  variant of: http://identifiers.org/hgnc/11993
canonical: false
consequence: 3' UTR
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 266
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1209
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 54
  bin: 5.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3676
  bin: 1.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13182
  bin: 2.75e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5096
  bin: 1.75e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 785
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 128
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31495
  bin: 2.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 4375
  bin: 3.25e1
  variant carriers: 6
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 333
  bin: 4.25e1
  variant carriers: 3
genotype quality: GenotypeQuality
  all individuals: 350
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 33083
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 253
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 196
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 438
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2912
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 402
  bin: 5.75e1
  variant carriers: 0
num of homozygotes: 0
population: Latino
population: South Asian
population: Other
population: African
population: European (Non-Finnish)
population: European (Finnish)
population: East Asian
reference allele: G
site quality: QD
site quality: FS
site quality: DP
site quality: MQRankSum
site quality: ReadPosRankSum
site quality: BaseQRankSum
site quality: VQSLOD
site quality: InbreedingCoeff
site quality: MQ
site quality: ClippingRankSum

22-22316991-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22316991
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22316991
    reference: chr 22
allele count: 1
allele frequency: 8.464103736055389e-6
allele num: 118146
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*168-17G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.736-17G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1171G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.539-17G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1352-17G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1352-17G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.150-17G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1044-17G>A
  variant of: http://identifiers.org/hgnc/11993
canonical: false
consequence: 3' UTR
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 4552
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13426
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1216
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 133
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4779
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 259
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 342
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3682
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31348
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 56
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 810
  bin: 3.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1314
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 310
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1255
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1615
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 656
  bin: 9.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 6738
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 44
  bin: 2.5e0
  variant carriers: 0
num of homozygotes: 0
population: European (Non-Finnish)
population: Other
population: European (Finnish)
population: East Asian
population: South Asian
population: African
population: Latino
reference allele: C
site quality: BaseQRankSum
site quality: VQSLOD
site quality: MQRankSum
site quality: FS
site quality: ReadPosRankSum
site quality: QD
site quality: InbreedingCoeff
site quality: MQ
site quality: DP
site quality: ClippingRankSum

22-22316992-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22316992
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22316992
    reference: chr 22
allele count: 4
allele frequency: 3.389256058295204e-5
allele num: 118020
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.539-18C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.736-18C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*168-18C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1170C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1352-18C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1044-18C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1352-18C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.150-18C>T
  variant of: http://identifiers.org/hgnc/11993
canonical: false
consequence: 3' UTR
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 1232
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 135
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31035
  bin: 2.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 355
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3702
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4757
  bin: 1.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 4657
  bin: 3.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 57
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 839
  bin: 3.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 258
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13577
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2986
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6752
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 322
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 83
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 935
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1866
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1617
  bin: 2.75e1
  variant carriers: 0
num of homozygotes: 0
population: African
population: East Asian
population: Latino
population: Other
population: European (Finnish)
population: South Asian
population: European (Non-Finnish)
reference allele: G
site quality: FS
site quality: VQSLOD
site quality: ClippingRankSum
site quality: QD
site quality: InbreedingCoeff
site quality: DP
site quality: BaseQRankSum
site quality: MQ
site quality: MQRankSum
site quality: ReadPosRankSum

http://identifiers.org/exac.variant/22-22316993-C-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22316993
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22316993
    reference: chr 22
allele count: 2
allele frequency: 1.692448295704566e-5
allele num: 118172
alternate allele: A
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1352-19G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*168-19G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.150-19G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.539-19G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1169G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.736-19G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1044-19G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1352-19G>T
  variant of: http://identifiers.org/hgnc/11993
canonical: false
consequence: 3' UTR
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4571
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 257
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 350
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31122
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 57
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13707
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1242
  bin: 7.5e0
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 135
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4637
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3688
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 839
  bin: 3.75e1
  variant carriers: 2
genotype quality: GenotypeQuality
  all individuals: 3008
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2465
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 348
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2510
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 732
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 35
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1752
  bin: 3.75e1
  variant carriers: 0
num of homozygotes: 0
population: Latino
population: European (Finnish)
population: East Asian
population: Other
population: African
population: European (Non-Finnish)
population: South Asian
reference allele: C
site quality: FS
site quality: ReadPosRankSum
site quality: MQ
site quality: InbreedingCoeff
site quality: MQRankSum
site quality: BaseQRankSum
site quality: VQSLOD
site quality: ClippingRankSum
site quality: DP
site quality: QD

22-22317008-A-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317008
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317008
    reference: chr 22
allele count: 1
allele frequency: 8.460236886632826e-6
allele num: 118200
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.539-34T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*168-34T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.150-34T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1154T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.736-34T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1352-34T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1352-34T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1044-34T>C
  variant of: http://identifiers.org/hgnc/11993
canonical: false
consequence: 3' UTR
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 206
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14229
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31445
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 394
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 139
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5212
  bin: 3.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 58
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1309
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 946
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3445
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3229
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 107
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2628
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 499
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1620
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 253
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 7449
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1638
  bin: 8.25e1
  variant carriers: 0
num of homozygotes: 0
population: European (Finnish)
population: South Asian
population: Latino
population: African
population: European (Non-Finnish)
population: East Asian
population: Other
reference allele: A
site quality: BaseQRankSum
site quality: MQRankSum
site quality: VQSLOD
site quality: ClippingRankSum
site quality: InbreedingCoeff
site quality: MQ
site quality: ReadPosRankSum
site quality: FS
site quality: DP
site quality: QD

22-22317019-C-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317019
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317019
    reference: chr 22
allele count: 1
allele frequency: 8.452513777597457e-6
allele num: 118308
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*168-45G>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.539-45G>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1352-45G>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1352-45G>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1044-45G>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1143G>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.150-45G>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.736-45G>C
  variant of: http://identifiers.org/hgnc/11993
canonical: false
consequence: 3' UTR
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 14695
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31525
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1029
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 440
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2824
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 164
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2775
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1240
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 58
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5718
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 145
  bin: 4.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 561
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 659
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 765
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2321
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1137
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3133
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 48
  bin: 2.5e0
  variant carriers: 0
num of homozygotes: 0
population: Latino
population: European (Non-Finnish)
population: European (Finnish)
population: East Asian
population: African
population: South Asian
population: Other
reference allele: C
site quality: DP
site quality: QD
site quality: FS
site quality: ClippingRankSum
site quality: InbreedingCoeff
site quality: VQSLOD
site quality: MQRankSum
site quality: BaseQRankSum
site quality: MQ
site quality: ReadPosRankSum

22-22317020-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317020
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317020
    reference: chr 22
allele count: 13
allele frequency: 1.099217019261664e-4
allele num: 118266
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1044-46G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.736-46G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*168-46G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.150-46G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1352-46G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1142G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1352-46G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.539-46G>A
  variant of: http://identifiers.org/hgnc/11993
canonical: false
consequence: 3' UTR
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 2696
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 146
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14831
  bin: 2.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 1063
  bin: 3.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 2702
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1229
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31444
  bin: 2.25e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 155
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 5.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 63
  bin: 5.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 5831
  bin: 3.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 6.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 453
  bin: 4.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 34141
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 151
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 73
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3172
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1851
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 668
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 771
  bin: 4.75e1
  variant carriers: 0
num of homozygotes: 0
population: European (Finnish)
population: South Asian
population: Other
population: European (Non-Finnish)
population: Latino
population: East Asian
population: African
reference allele: C
site quality: ClippingRankSum
site quality: InbreedingCoeff
site quality: MQRankSum
site quality: FS
site quality: MQ
site quality: VQSLOD
site quality: ReadPosRankSum
site quality: DP
site quality: QD
site quality: BaseQRankSum

22-22317069-TTGTC-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317069
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317065
    reference: chr 22
allele count: 2
allele frequency: 1.652127940787734e-5
allele num: 121056
alternate allele: T
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1351+46_1351+49delGACA
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.735+46_735+49delGACA
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1351+46_1351+49delGACA
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*167+46_*167+49delGACA
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.149+46_149+49delGACA
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1089_*1092delGACA
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.538+46_538+49delGACA
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1043+46_*1043+49delGACA
  variant of: http://identifiers.org/hgnc/11993
canonical: false
consequence: 3' UTR
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 918
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 38
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 379
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12436
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 30
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 458
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 219
  bin: 4.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 11500
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 8.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 32350
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 132
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1857
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 77
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 94
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 53
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 17
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 136
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 22
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 10
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 43528
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 350
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 381
  bin: 5.25e1
  variant carriers: 0
num of homozygotes: 0
population: South Asian
population: Latino
population: Other
population: East Asian
population: European (Finnish)
population: African
population: European (Non-Finnish)
reference allele: TTGTC
site quality: InbreedingCoeff
site quality: VQSLOD
site quality: QD
site quality: DP
site quality: MQRankSum
site quality: BaseQRankSum
site quality: ReadPosRankSum
site quality: MQ
site quality: FS
site quality: ClippingRankSum

22-22317069-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317069
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317069
    reference: chr 22
allele count: 1
allele frequency: 8.260639703938672e-6
allele num: 121056
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1093A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1351+50A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.538+50A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.149+50A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*167+50A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1043+50A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1351+50A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.735+50A>G
  variant of: http://identifiers.org/hgnc/11993
canonical: false
consequence: 3' UTR
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 458
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32350
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 30
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 379
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11500
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12436
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 53
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 132
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 219
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 918
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 94
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 77
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1857
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 38
  bin: 8.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 43528
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 22
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9246
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 227
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 189
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 221
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 17
  bin: 1.25e1
  variant carriers: 0
num of homozygotes: 0
population: African
population: East Asian
population: South Asian
population: Other
population: Latino
population: European (Non-Finnish)
population: European (Finnish)
reference allele: T
site quality: BaseQRankSum
site quality: InbreedingCoeff
site quality: MQRankSum
site quality: VQSLOD
site quality: DP
site quality: MQ
site quality: ClippingRankSum
site quality: QD
site quality: ReadPosRankSum
site quality: FS

22-22317079-A-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317079
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317079
    reference: chr 22
allele count: 1
allele frequency: 8.260912665631299e-6
allele num: 121052
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*167+40T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1351+40T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.149+40T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.735+40T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1043+40T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1083T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.538+40T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1351+40T>C
  variant of: http://identifiers.org/hgnc/11993
canonical: false
consequence: 3' UTR
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 346
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12452
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 136
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 504
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 219
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11810
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 37
  bin: 8.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 77
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 93
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 54
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1840
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 451
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32494
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 30
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 11
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 121
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 812
  bin: 9.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 113
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 14
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 173
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 212
  bin: 9.25e1
  variant carriers: 0
num of homozygotes: 0
population: European (Finnish)
population: Other
population: African
population: European (Non-Finnish)
population: South Asian
population: Latino
population: East Asian
reference allele: A
site quality: MQRankSum
site quality: ClippingRankSum
site quality: FS
site quality: ReadPosRankSum
site quality: QD
site quality: InbreedingCoeff
site quality: MQ
site quality: DP
site quality: VQSLOD
site quality: BaseQRankSum

http://identifiers.org/exac.variant/22-22317087-A-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317087
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317087
    reference: chr 22
allele count: 1
allele frequency: 8.260503229856763e-6
allele num: 121058
alternate allele: C
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1351+32T>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1351+32T>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1043+32T>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.538+32T>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.149+32T>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1075T>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*167+32T>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.735+32T>G
  variant of: http://identifiers.org/hgnc/11993
canonical: false
consequence: 3' UTR
filter: VQSRTrancheSNP99.60to99.80
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1831
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12468
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32614
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 263
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 453
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 30
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11982
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 77
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 216
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 137
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 289
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 94
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 36
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 108
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 722
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 212
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2025
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9279
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 21
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 14
  bin: 1.25e1
  variant carriers: 0
num of homozygotes: 0
population: East Asian
population: European (Finnish)
population: Latino
population: South Asian
population: Other
population: African
population: European (Non-Finnish)
reference allele: A
site quality: MQRankSum
site quality: DP
site quality: MQ
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: FS
site quality: VQSLOD
site quality: ReadPosRankSum
site quality: InbreedingCoeff
site quality: QD

http://identifiers.org/exac.variant/22-22317088-C-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317088
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317088
    reference: chr 22
allele count: 1
allele frequency: 8.261049153242462e-6
allele num: 121050
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1351+31G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.538+31G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.735+31G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.149+31G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1074G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*167+31G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1351+31G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1043+31G>T
  variant of: http://identifiers.org/hgnc/11993
canonical: false
consequence: 3' UTR
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 216
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 454
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 282
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 76
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 248
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 94
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1830
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32630
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 8.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 36
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 136
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11979
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12479
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 15
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 136
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9264
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 805
  bin: 9.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 70
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 49
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 19
  bin: 7.5e0
  variant carriers: 0
num of homozygotes: 0
population: African
population: South Asian
population: European (Finnish)
population: European (Non-Finnish)
population: Latino
population: East Asian
population: Other
reference allele: C
site quality: MQ
site quality: ClippingRankSum
site quality: ReadPosRankSum
site quality: QD
site quality: VQSLOD
site quality: FS
site quality: InbreedingCoeff
site quality: DP
site quality: MQRankSum
site quality: BaseQRankSum

22-22317089-AGAG-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317089
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317086
    reference: chr 22
allele count: 2
allele frequency: 1.652100645971353e-5
allele num: 121058
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.735+27_735+29delCTC
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*167+27_*167+29delCTC
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1351+27_1351+29delCTC
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.149+27_149+29delCTC
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1070_*1072delCTC
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1043+27_*1043+29delCTC
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.538+27_538+29delCTC
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1351+27_1351+29delCTC
  variant of: http://identifiers.org/hgnc/11993
canonical: false
consequence: 3' UTR
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 12467
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 272
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 44
  bin: 6.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32656
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 76
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 216
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1829
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 56
  bin: 5.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 137
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 91
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 226
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 451
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 36
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12002
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 22
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 17
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 70
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 101
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 10
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 807
  bin: 9.75e1
  variant carriers: 2
genotype quality: GenotypeQuality
  all individuals: 222
  bin: 8.75e1
  variant carriers: 0
num of homozygotes: 0
population: European (Finnish)
population: Other
population: East Asian
population: European (Non-Finnish)
population: African
population: South Asian
population: Latino
reference allele: AGAG
site quality: VQSLOD
site quality: FS
site quality: MQRankSum
site quality: MQ
site quality: DP
site quality: BaseQRankSum
site quality: ReadPosRankSum
site quality: QD
site quality: ClippingRankSum
site quality: InbreedingCoeff

22-22317101-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317101
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317101
    reference: chr 22
allele count: 1
allele frequency: 8.259548037531387e-6
allele num: 121072
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.538+18G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.735+18G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1351+18G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*167+18G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.149+18G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1061G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1351+18G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1043+18G>A
  variant of: http://identifiers.org/hgnc/11993
canonical: false
consequence: 3' UTR
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 1833
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 91
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 453
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 196
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 142
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12494
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 127
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12051
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32749
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 215
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 76
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 36
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 44
  bin: 6.25e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 2020
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 45
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 215
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 70
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 10
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 210
  bin: 9.25e1
  variant carriers: 0
num of homozygotes: 0
population: South Asian
population: European (Non-Finnish)
population: East Asian
population: African
population: Latino
population: European (Finnish)
population: Other
reference allele: C
site quality: VQSLOD
site quality: InbreedingCoeff
site quality: MQRankSum
site quality: BaseQRankSum
site quality: DP
site quality: MQ
site quality: FS
site quality: ReadPosRankSum
site quality: ClippingRankSum
site quality: QD

22-22317108-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317108
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317108
    reference: chr 22
allele count: 2
allele frequency: 1.65174589541145e-5
allele num: 121084
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1351+11G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*167+11G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.538+11G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1054G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1351+11G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.735+11G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1043+11G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.149+11G>A
  variant of: http://identifiers.org/hgnc/11993
canonical: false
consequence: 3' UTR
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 140
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 8.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 53
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 77
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 216
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12037
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 98
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 35
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32835
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1834
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 164
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 450
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12488
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 30
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 93
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2019
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 29
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9296
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 36
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 208
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4
  bin: 1.25e1
  variant carriers: 0
num of homozygotes: 0
population: South Asian
population: Other
population: European (Non-Finnish)
population: Latino
population: African
population: East Asian
population: European (Finnish)
reference allele: C
site quality: ReadPosRankSum
site quality: FS
site quality: ClippingRankSum
site quality: InbreedingCoeff
site quality: MQ
site quality: BaseQRankSum
site quality: QD
site quality: VQSLOD
site quality: MQRankSum
site quality: DP

22-22317109-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317109
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317109
    reference: chr 22
allele count: 1
allele frequency: 8.258320257659592e-6
allele num: 121090
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1053C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.735+10C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1043+10C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.149+10C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1351+10C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*167+10C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1351+10C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.538+10C>T
  variant of: http://identifiers.org/hgnc/11993
canonical: false
consequence: 3' UTR
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 53
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 44
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 447
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 159
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1832
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32855
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 215
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12489
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 92
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12038
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 93
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 138
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 77
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 207
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 54
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 7
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 5
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2023
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 802
  bin: 9.75e1
  variant carriers: 1
num of homozygotes: 0
population: South Asian
population: East Asian
population: European (Finnish)
population: African
population: Latino
population: European (Non-Finnish)
population: Other
reference allele: G
site quality: BaseQRankSum
site quality: ReadPosRankSum
site quality: InbreedingCoeff
site quality: DP
site quality: FS
site quality: MQRankSum
site quality: QD
site quality: ClippingRankSum
site quality: VQSLOD
site quality: MQ

22-22317112-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317112
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317112
    reference: chr 22
allele count: 1
allele frequency: 8.257365570088519e-6
allele num: 121104
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1351+7C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.149+7C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1043+7C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.735+7C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.538+7C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*167+7C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1050C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1351+7C>T
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: splice region
filter: VQSRTrancheSNP99.60to99.80
genotype depth: GenotypeDepth
  all individuals: 215
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12040
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12498
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32859
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 133
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 90
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 44
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 54
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 446
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 150
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 92
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 76
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1833
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 12
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 708
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 7
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 194
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 45150
  bin: 6.25e1
  variant carriers: 0
hgvs: c.1351+7C>T
num of homozygotes: 0
population: South Asian
population: European (Finnish)
population: East Asian
population: Other
population: Latino
population: European (Non-Finnish)
population: African
reference allele: G
site quality: MQ
site quality: InbreedingCoeff
site quality: ReadPosRankSum
site quality: FS
site quality: MQRankSum
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: VQSLOD
site quality: DP
site quality: QD

22-22317115-T-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317115
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317115
    reference: chr 22
allele count: 1
allele frequency: 8.257774694875225e-6
allele num: 121098
alternate allele: G
annotation: Annotation
  canonical: true
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1351+4A>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.538+4A>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.149+4A>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.735+4A>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1351+4A>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1047A>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1043+4A>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*167+4A>C
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: splice region
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 8.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 1833
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 54
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 131
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 137
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12502
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 81
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12049
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 446
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32872
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 92
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 44
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 75
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 214
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 45
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 15
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9313
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6
  bin: 5.75e1
  variant carriers: 0
hgvs: c.1351+4A>C
num of homozygotes: 0
population: European (Finnish)
population: East Asian
population: European (Non-Finnish)
population: Latino
population: South Asian
population: African
population: Other
reference allele: T
site quality: QD
site quality: ClippingRankSum
site quality: MQRankSum
site quality: DP
site quality: BaseQRankSum
site quality: FS
site quality: VQSLOD
site quality: MQ
site quality: InbreedingCoeff
site quality: ReadPosRankSum

22-22317131-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317131
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317131
    reference: chr 22
allele count: 2
allele frequency: 1.651364026686043e-5
allele num: 121112
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.137G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1339G>A
  hgvsp: ENSP00000381773.2:p.Val447Ile
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1031G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1031G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.723G>A
  hgvsp: ENSP00000408282.1:p.Val242Ile
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*155G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1339G>A
  hgvsp: ENSP00000349705.5:p.Val447Ile
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.526G>A
  hgvsp: ENSP00000393118.2:p.Val176Ile
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 92
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 77
  bin: 9.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 112
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 130
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 213
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 53
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12053
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32897
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 73
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 447
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12506
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1836
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 29
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 180
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 0
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 18
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 16
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 40
  bin: 3.25e1
  variant carriers: 0
hgvs: p.Val447Ile
num of homozygotes: 0
population: Latino
population: African
population: South Asian
population: Other
population: European (Non-Finnish)
population: European (Finnish)
population: East Asian
reference allele: C
site quality: ReadPosRankSum
site quality: BaseQRankSum
site quality: FS
site quality: DP
site quality: ClippingRankSum
site quality: InbreedingCoeff
site quality: VQSLOD
site quality: MQRankSum
site quality: MQ
site quality: QD

22-22317132-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317132
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317132
    reference: chr 22
allele count: 208
allele frequency: 1.7174753112924e-3
allele num: 121108
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1030C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.722C>T
  hgvsp: ENST00000457270.1:c.722C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1030C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1338C>T
  hgvsp: ENST00000398793.2:c.1338C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.136C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*154C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1338C>T
  hgvsp: ENST00000357179.5:c.1338C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.525C>T
  hgvsp: ENST00000413067.2:c.525C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 47
  bin: 5.75e1
  variant carriers: 7
genotype depth: GenotypeDepth
  all individuals: 12505
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1821
  bin: 3.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 146
  bin: 9.75e1
  variant carriers: 117
genotype depth: GenotypeDepth
  all individuals: 26
  bin: 6.75e1
  variant carriers: 8
genotype depth: GenotypeDepth
  all individuals: 32894
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 66
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 9.25e1
  variant carriers: 12
genotype depth: GenotypeDepth
  all individuals: 25
  bin: 7.75e1
  variant carriers: 10
genotype depth: GenotypeDepth
  all individuals: 129
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12057
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 8.25e1
  variant carriers: 10
genotype depth: GenotypeDepth
  all individuals: 111
  bin: 1.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 6.25e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 209
  bin: 4.75e1
  variant carriers: 5
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 7.25e1
  variant carriers: 11
genotype depth: GenotypeDepth
  all individuals: 439
  bin: 4.25e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 86
  bin: 5.25e1
  variant carriers: 4
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 8.75e1
  variant carriers: 15
genotype quality: GenotypeQuality
  all individuals: 172
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 703
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 45232
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2026
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 12
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 15
  bin: 7.5e0
  variant carriers: 0
hgvs: p.Thr446Thr
num of homozygotes: 0
population: South Asian
population: European (Finnish)
population: African
population: East Asian
population: Latino
population: European (Non-Finnish)
population: Other
reference allele: G
site quality: ReadPosRankSum
site quality: MQ
site quality: InbreedingCoeff
site quality: BaseQRankSum
site quality: MQRankSum
site quality: VQSLOD
site quality: ClippingRankSum
site quality: DP
site quality: FS
site quality: QD

22-22317136-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317136
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317136
    reference: chr 22
allele count: 1
allele frequency: 8.257092842751923e-6
allele num: 121108
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.521A>G
  hgvsp: ENSP00000393118.2:p.Lys174Arg
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1026A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1334A>G
  hgvsp: ENSP00000381773.2:p.Lys445Arg
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.132A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1334A>G
  hgvsp: ENSP00000349705.5:p.Lys445Arg
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1026A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.718A>G
  hgvsp: ENSP00000408282.1:p.Lys240Arg
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*150A>G
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 41
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 133
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12554
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 81
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 436
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 206
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 60
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 104
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 33005
  bin: 2.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 12104
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1825
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 15
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1850
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 13
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 7
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 609
  bin: 9.75e1
  variant carriers: 1
hgvs: p.Lys445Arg
num of homozygotes: 0
population: European (Finnish)
population: European (Non-Finnish)
population: East Asian
population: Latino
population: South Asian
population: Other
population: African
reference allele: T
site quality: MQ
site quality: InbreedingCoeff
site quality: QD
site quality: FS
site quality: VQSLOD
site quality: MQRankSum
site quality: BaseQRankSum
site quality: DP
site quality: ReadPosRankSum
site quality: ClippingRankSum

22-22317140-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317140
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317140
    reference: chr 22
allele count: 2
allele frequency: 1.651364026686043e-5
allele num: 121112
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1330G>A
  hgvsp: ENSP00000349705.5:p.Gly444Arg
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.517G>A
  hgvsp: ENSP00000393118.2:p.Gly173Arg
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1022G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1022G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*146G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.128G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.714G>A
  hgvsp: ENSP00000408282.1:p.Gly239Arg
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1330G>A
  hgvsp: ENSP00000381773.2:p.Gly444Arg
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 59
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 30
  bin: 9.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 12557
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 33004
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 205
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 83
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 130
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 107
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 436
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1825
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12098
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 13
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 15
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 10
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 36
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 15
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 31
  bin: 2.75e1
  variant carriers: 0
hgvs: p.Gly444Arg
num of homozygotes: 0
population: Other
population: South Asian
population: African
population: European (Finnish)
population: European (Non-Finnish)
population: East Asian
population: Latino
reference allele: C
site quality: QD
site quality: FS
site quality: BaseQRankSum
site quality: ReadPosRankSum
site quality: ClippingRankSum
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: MQ
site quality: VQSLOD
site quality: DP

22-22317141-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317141
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317141
    reference: chr 22
allele count: 4
allele frequency: 3.302728053372085e-5
allele num: 121112
alternate allele: A
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1329C>T
  hgvsp: ENST00000398793.2:c.1329C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1021C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*145C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.713C>T
  hgvsp: ENST00000457270.1:c.713C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1021C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.127C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1329C>T
  hgvsp: ENST00000357179.5:c.1329C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.516C>T
  hgvsp: ENST00000413067.2:c.516C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 129
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1824
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 436
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12100
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 33008
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 205
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32
  bin: 9.75e1
  variant carriers: 4
genotype depth: GenotypeDepth
  all individuals: 12557
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 59
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 106
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 25
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 80
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 702
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 7
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 15
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 12
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 21
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 35
  bin: 3.25e1
  variant carriers: 0
hgvs: p.Ser443Ser
num of homozygotes: 0
population: Other
population: European (Non-Finnish)
population: African
population: Latino
population: European (Finnish)
population: South Asian
population: East Asian
reference allele: G
site quality: BaseQRankSum
site quality: MQRankSum
site quality: FS
site quality: ReadPosRankSum
site quality: InbreedingCoeff
site quality: ClippingRankSum
site quality: MQ
site quality: VQSLOD
site quality: DP
site quality: QD

22-22317144-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317144
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317144
    reference: chr 22
allele count: 1
allele frequency: 8.257092842751923e-6
allele num: 121108
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*142C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1326C>T
  hgvsp: ENST00000398793.2:c.1326C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1018C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1326C>T
  hgvsp: ENST00000357179.5:c.1326C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.513C>T
  hgvsp: ENST00000413067.2:c.513C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1018C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.124C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.710C>T
  hgvsp: ENST00000457270.1:c.710C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 12557
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 33014
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1823
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 109
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 205
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12102
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 131
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 436
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 52
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 25
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 80
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 14
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 45416
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 702
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 16
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 203
  bin: 9.25e1
  variant carriers: 0
hgvs: p.Cys442Cys
num of homozygotes: 0
population: African
population: Latino
population: European (Non-Finnish)
population: East Asian
population: European (Finnish)
population: South Asian
population: Other
reference allele: G
site quality: VQSLOD
site quality: BaseQRankSum
site quality: DP
site quality: ReadPosRankSum
site quality: MQRankSum
site quality: ClippingRankSum
site quality: FS
site quality: MQ
site quality: QD
site quality: InbreedingCoeff

22-22317154-A-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317154
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317154
    reference: chr 22
allele count: 17
allele frequency: 1.403821698128788e-4
allele num: 121098
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.114T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.503T>C
  hgvsp: ENSP00000393118.2:p.Leu168Pro
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1008T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.700T>C
  hgvsp: ENSP00000408282.1:p.Leu234Pro
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1316T>C
  hgvsp: ENSP00000349705.5:p.Leu439Pro
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1008T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*132T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1316T>C
  hgvsp: ENSP00000381773.2:p.Leu439Pro
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 107
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 435
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 33027
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 50
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.25e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 26
  bin: 6.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 201
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 6.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12094
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12559
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1821
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 40
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 35
  bin: 9.75e1
  variant carriers: 11
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 9.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 131
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 80
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 601
  bin: 9.75e1
  variant carriers: 17
genotype quality: GenotypeQuality
  all individuals: 11
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 14
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 701
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 211
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 11
  bin: 5.75e1
  variant carriers: 0
hgvs: p.Leu439Pro
num of homozygotes: 0
population: African
population: Other
population: Latino
population: East Asian
population: European (Finnish)
population: European (Non-Finnish)
population: South Asian
reference allele: A
site quality: MQRankSum
site quality: DP
site quality: ReadPosRankSum
site quality: QD
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: FS
site quality: InbreedingCoeff
site quality: MQ
site quality: VQSLOD

22-22317158-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317158
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317158
    reference: chr 22
allele count: 2
allele frequency: 1.651582215762701e-5
allele num: 121096
alternate allele: T
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1312G>A
  hgvsp: ENSP00000381773.2:p.Glu438Lys
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.499G>A
  hgvsp: ENSP00000393118.2:p.Glu167Lys
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*128G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.696G>A
  hgvsp: ENSP00000408282.1:p.Glu233Lys
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1312G>A
  hgvsp: ENSP00000349705.5:p.Glu438Lys
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.110G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1004G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1004G>A
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 201
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 107
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12563
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 40
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 33031
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 50
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 80
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1822
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12095
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 137
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 25
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 436
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 9.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 25
  bin: 9.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 14
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1852
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 30
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2029
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 30
  bin: 2.75e1
  variant carriers: 0
hgvs: p.Glu438Lys
num of homozygotes: 0
population: European (Finnish)
population: East Asian
population: Latino
population: African
population: Other
population: European (Non-Finnish)
population: South Asian
reference allele: C
site quality: QD
site quality: ClippingRankSum
site quality: FS
site quality: BaseQRankSum
site quality: DP
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: VQSLOD
site quality: MQ
site quality: ReadPosRankSum

http://identifiers.org/exac.variant/22-22317162-C-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317162
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317162
    reference: chr 22
allele count: 1
allele frequency: 8.258593066085262e-6
allele num: 121086
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*124G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1308G>T
  hgvsp: ENST00000398793.2:c.1308G>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*1000G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1308G>T
  hgvsp: ENST00000357179.5:c.1308G>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*1000G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.495G>T
  hgvsp: ENST00000413067.2:c.495G>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.106G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.692G>T
  hgvsp: ENST00000457270.1:c.692G>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 33026
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 199
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 46
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1824
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 80
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 25
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12108
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12560
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 141
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 106
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 39
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 25
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 436
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 13
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 29
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 191
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 700
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9351
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 30
  bin: 3.25e1
  variant carriers: 0
hgvs: p.Gly436Gly
num of homozygotes: 0
population: African
population: South Asian
population: European (Non-Finnish)
population: Latino
population: East Asian
population: Other
population: European (Finnish)
reference allele: C
site quality: MQRankSum
site quality: VQSLOD
site quality: InbreedingCoeff
site quality: MQ
site quality: ReadPosRankSum
site quality: QD
site quality: DP
site quality: BaseQRankSum
site quality: FS
site quality: ClippingRankSum

http://identifiers.org/exac.variant/22-22317165-A-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317165
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317165
    reference: chr 22
allele count: 6
allele frequency: 4.955155839651157e-5
allele num: 121086
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*997T>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*121T>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1305T>G
  hgvsp: ENSP00000381773.2:p.Ile435Met
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.103T>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*997T>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.492T>G
  hgvsp: ENSP00000393118.2:p.Ile164Met
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.689T>G
  hgvsp: ENSP00000408282.1:p.Ile230Met
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1305T>G
  hgvsp: ENSP00000349705.5:p.Ile435Met
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 38
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 8.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 113
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 33033
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12100
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 79
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 141
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12555
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 197
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 436
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1824
  bin: 3.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 33
  bin: 9.75e1
  variant carriers: 4
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 585
  bin: 9.75e1
  variant carriers: 6
genotype quality: GenotypeQuality
  all individuals: 1847
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2029
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 30
  bin: 2.75e1
  variant carriers: 0
hgvs: p.Ile435Met
num of homozygotes: 0
population: African
population: East Asian
population: European (Non-Finnish)
population: European (Finnish)
population: South Asian
population: Other
population: Latino
reference allele: A
site quality: FS
site quality: MQRankSum
site quality: DP
site quality: VQSLOD
site quality: QD
site quality: MQ
site quality: InbreedingCoeff
site quality: BaseQRankSum
site quality: ReadPosRankSum
site quality: ClippingRankSum

22-22317165-A-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317165
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317165
    reference: chr 22
allele count: 14
allele frequency: 1.156203029251937e-4
allele num: 121086
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1305T>C
  hgvsp: ENST00000357179.5:c.1305T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.689T>C
  hgvsp: ENST00000457270.1:c.689T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.103T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1305T>C
  hgvsp: ENST00000398793.2:c.1305T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*121T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*997T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*997T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.492T>C
  hgvsp: ENST00000413067.2:c.492T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 7.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 436
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 6.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 113
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12100
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 197
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 38
  bin: 5.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 141
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12555
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 79
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 33
  bin: 9.75e1
  variant carriers: 8
genotype depth: GenotypeDepth
  all individuals: 33033
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1824
  bin: 3.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 6.25e1
  variant carriers: 2
genotype quality: GenotypeQuality
  all individuals: 198
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 30
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 698
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 15
  bin: 7.5e0
  variant carriers: 0
hgvs: p.Ile435Ile
num of homozygotes: 0
population: African
population: Other
population: East Asian
population: Latino
population: South Asian
population: European (Finnish)
population: European (Non-Finnish)
reference allele: A
site quality: VQSLOD
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: QD
site quality: InbreedingCoeff
site quality: FS
site quality: ReadPosRankSum
site quality: MQ
site quality: MQRankSum
site quality: DP

22-22317173-A-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317173
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317173
    reference: chr 22
allele count: 1
allele frequency: 8.259684480052863e-6
allele num: 121070
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*989T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*989T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.681T>C
  hgvsp: ENSP00000408282.1:p.Phe228Leu
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*113T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1297T>C
  hgvsp: ENSP00000349705.5:p.Phe433Leu
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.95T>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1297T>C
  hgvsp: ENSP00000381773.2:p.Phe433Leu
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.484T>C
  hgvsp: ENSP00000393118.2:p.Phe162Leu
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 37
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 116
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 148
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 25
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 79
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 197
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 436
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1821
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12103
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12562
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 33042
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 13
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 699
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 10
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 208
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 45455
  bin: 6.25e1
  variant carriers: 0
hgvs: p.Phe433Leu
num of homozygotes: 0
population: South Asian
population: African
population: East Asian
population: Latino
population: Other
population: European (Non-Finnish)
population: European (Finnish)
reference allele: A
site quality: ReadPosRankSum
site quality: InbreedingCoeff
site quality: VQSLOD
site quality: MQ
site quality: DP
site quality: FS
site quality: ClippingRankSum
site quality: MQRankSum
site quality: QD
site quality: BaseQRankSum

22-22317174-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317174
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317174
    reference: chr 22
allele count: 3
allele frequency: 2.477782549803429e-5
allele num: 121076
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.680C>T
  hgvsp: ENST00000457270.1:c.680C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*988C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.483C>T
  hgvsp: ENST00000413067.2:c.483C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.94C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1296C>T
  hgvsp: ENST00000357179.5:c.1296C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1296C>T
  hgvsp: ENST00000398793.2:c.1296C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*112C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*988C>T
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 116
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12559
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 80
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 37
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1820
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 33041
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12106
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 147
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 197
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 25
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 436
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 24
  bin: 9.75e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 27
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 33
  bin: 2.75e1
  variant carriers: 0
hgvs: p.Ser432Ser
num of homozygotes: 0
population: East Asian
population: African
population: Other
population: European (Finnish)
population: South Asian
population: Latino
population: European (Non-Finnish)
reference allele: G
site quality: VQSLOD
site quality: ClippingRankSum
site quality: MQRankSum
site quality: FS
site quality: MQ
site quality: InbreedingCoeff
site quality: QD
site quality: DP
site quality: BaseQRankSum
site quality: ReadPosRankSum

http://identifiers.org/exac.variant/22-22317178-A-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317178
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317178
    reference: chr 22
allele count: 2
allele frequency: 1.651991475723985e-5
allele num: 121066
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*984T>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.676T>G
  hgvsp: ENSP00000408282.1:p.Ile226Ser
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1292T>G
  hgvsp: ENSP00000349705.5:p.Ile431Ser
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.90T>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*984T>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.479T>G
  hgvsp: ENSP00000393118.2:p.Ile160Ser
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1292T>G
  hgvsp: ENSP00000381773.2:p.Ile431Ser
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*108T>G
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 80
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 33045
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 148
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12557
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 198
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 123
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12100
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26
  bin: 6.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 37
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 434
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1822
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 34
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 10
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2026
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 26
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2
  bin: 2.5e0
  variant carriers: 0
hgvs: p.Ile431Ser
num of homozygotes: 0
population: European (Non-Finnish)
population: European (Finnish)
population: East Asian
population: Latino
population: African
population: South Asian
population: Other
reference allele: A
site quality: ClippingRankSum
site quality: InbreedingCoeff
site quality: BaseQRankSum
site quality: VQSLOD
site quality: DP
site quality: QD
site quality: FS
site quality: MQRankSum
site quality: ReadPosRankSum
site quality: MQ

http://identifiers.org/exac.variant/22-22317189-C-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317189
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317189
    reference: chr 22
allele count: 68
allele frequency: 5.618348866415493e-4
allele num: 121032
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*973G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1281G>T
  hgvsp: ENST00000398793.2:c.1281G>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.468G>T
  hgvsp: ENST00000413067.2:c.468G>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*973G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1281G>T
  hgvsp: ENST00000357179.5:c.1281G>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.79G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*97G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.665G>T
  hgvsp: ENST00000457270.1:c.665G>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 5.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 188
  bin: 4.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12554
  bin: 3.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 129
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 33034
  bin: 2.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 7.75e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 164
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12079
  bin: 2.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 38
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 8.75e1
  variant carriers: 4
genotype depth: GenotypeDepth
  all individuals: 1819
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 8.25e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 22
  bin: 6.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 77
  bin: 5.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 16
  bin: 6.75e1
  variant carriers: 5
genotype depth: GenotypeDepth
  all individuals: 434
  bin: 4.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 7.25e1
  variant carriers: 4
genotype depth: GenotypeDepth
  all individuals: 46
  bin: 9.75e1
  variant carriers: 36
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 9.25e1
  variant carriers: 2
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2021
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 206
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 25
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 34
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9347
  bin: 6.75e1
  variant carriers: 0
hgvs: p.Leu427Leu
num of homozygotes: 0
population: European (Non-Finnish)
population: African
population: Other
population: Latino
population: East Asian
population: South Asian
population: European (Finnish)
reference allele: C
site quality: InbreedingCoeff
site quality: ReadPosRankSum
site quality: FS
site quality: MQRankSum
site quality: VQSLOD
site quality: ClippingRankSum
site quality: QD
site quality: DP
site quality: BaseQRankSum
site quality: MQ

22-22317192-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317192
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317192
    reference: chr 22
allele count: 2
allele frequency: 1.652564780539397e-5
allele num: 121024
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1278C>T
  hgvsp: ENST00000357179.5:c.1278C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.662C>T
  hgvsp: ENST00000457270.1:c.662C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1278C>T
  hgvsp: ENST00000398793.2:c.1278C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.465C>T
  hgvsp: ENST00000413067.2:c.465C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.76C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*970C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*94C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*970C>T
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 164
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12569
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 187
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 76
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 434
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 33068
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1821
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 0
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 9.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 133
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12093
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 25
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 12
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 45501
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 700
  bin: 8.25e1
  variant carriers: 0
hgvs: p.Tyr426Tyr
num of homozygotes: 0
population: Other
population: European (Non-Finnish)
population: East Asian
population: European (Finnish)
population: Latino
population: African
population: South Asian
reference allele: G
site quality: ReadPosRankSum
site quality: InbreedingCoeff
site quality: BaseQRankSum
site quality: QD
site quality: MQRankSum
site quality: FS
site quality: ClippingRankSum
site quality: DP
site quality: VQSLOD
site quality: MQ

22-22317205-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317205
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317205
    reference: chr 22
allele count: 4
allele frequency: 3.308464706952739e-5
allele num: 120902
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.452A>G
  hgvsp: ENSP00000393118.2:p.His151Arg
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*81A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*957A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1265A>G
  hgvsp: ENSP00000349705.5:p.His422Arg
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1265A>G
  hgvsp: ENSP00000381773.2:p.His422Arg
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.649A>G
  hgvsp: ENSP00000408282.1:p.His217Arg
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.63A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*957A>G
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 76
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1820
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 9.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12026
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 33028
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 30
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 187
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 47
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12561
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 180
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 430
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 9.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 214
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 693
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 305
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 38
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2019
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 16
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 1.25e1
  variant carriers: 0
hgvs: p.His422Arg
num of homozygotes: 0
population: East Asian
population: European (Finnish)
population: South Asian
population: African
population: Other
population: Latino
population: European (Non-Finnish)
reference allele: T
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: VQSLOD
site quality: ReadPosRankSum
site quality: FS
site quality: DP
site quality: MQ
site quality: ClippingRankSum
site quality: BaseQRankSum
site quality: QD

22-22317209-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317209
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317209
    reference: chr 22
allele count: 1
allele frequency: 8.272119647938589e-6
allele num: 120888
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.59A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.448A>G
  hgvsp: ENSP00000393118.2:p.Ser150Gly
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*953A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*77A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.645A>G
  hgvsp: ENSP00000408282.1:p.Ser216Gly
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1261A>G
  hgvsp: ENSP00000381773.2:p.Ser421Gly
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*953A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1261A>G
  hgvsp: ENSP00000349705.5:p.Ser421Gly
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 12032
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 178
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 220
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12552
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 76
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 186
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 432
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 9.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1816
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 33037
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 16
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 37
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9334
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 313
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 18
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 20
  bin: 5.25e1
  variant carriers: 0
hgvs: p.Ser421Gly
num of homozygotes: 0
population: European (Non-Finnish)
population: Other
population: South Asian
population: Latino
population: East Asian
population: European (Finnish)
population: African
reference allele: T
site quality: ClippingRankSum
site quality: InbreedingCoeff
site quality: ReadPosRankSum
site quality: DP
site quality: FS
site quality: QD
site quality: MQ
site quality: VQSLOD
site quality: BaseQRankSum
site quality: MQRankSum

22-22317213-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317213
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317213
    reference: chr 22
allele count: 7
allele frequency: 5.7918252523581e-5
allele num: 120860
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.641G>A
  hgvsp: ENST00000457270.1:c.641G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1257G>A
  hgvsp: ENST00000398793.2:c.1257G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.444G>A
  hgvsp: ENST00000413067.2:c.444G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1257G>A
  hgvsp: ENST00000357179.5:c.1257G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.55G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*73G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*949G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*949G>A
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 36
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 46
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 6.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 188
  bin: 4.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 229
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 179
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 33033
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12542
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12034
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1811
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 9.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 426
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 7.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 76
  bin: 5.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 5.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 9.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 489
  bin: 9.75e1
  variant carriers: 7
genotype quality: GenotypeQuality
  all individuals: 20
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2013
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1835
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 323
  bin: 2.25e1
  variant carriers: 0
hgvs: p.Thr419Thr
num of homozygotes: 0
population: African
population: East Asian
population: Latino
population: European (Finnish)
population: South Asian
population: European (Non-Finnish)
population: Other
reference allele: C
site quality: DP
site quality: QD
site quality: ReadPosRankSum
site quality: BaseQRankSum
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: FS
site quality: ClippingRankSum
site quality: MQ
site quality: VQSLOD

22-22317214-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317214
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317214
    reference: chr 22
allele count: 3
allele frequency: 2.482416218452627e-5
allele num: 120850
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.54C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.640C>T
  hgvsp: ENSP00000408282.1:p.Thr214Met
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.443C>T
  hgvsp: ENSP00000393118.2:p.Thr148Met
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1256C>T
  hgvsp: ENSP00000349705.5:p.Thr419Met
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1256C>T
  hgvsp: ENSP00000381773.2:p.Thr419Met
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*72C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*948C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*948C>T
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 0
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 426
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 74
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 9.75e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 228
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 39
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12543
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1809
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 33030
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12039
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 48
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 186
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 186
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1835
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 45
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 10
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 686
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 11
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 10
  bin: 1.75e1
  variant carriers: 0
hgvs: p.Thr419Met
num of homozygotes: 0
population: South Asian
population: African
population: European (Non-Finnish)
population: Other
population: European (Finnish)
population: East Asian
population: Latino
reference allele: G
site quality: MQ
site quality: QD
site quality: BaseQRankSum
site quality: InbreedingCoeff
site quality: FS
site quality: VQSLOD
site quality: DP
site quality: MQRankSum
site quality: ReadPosRankSum
site quality: ClippingRankSum

22-22317216-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317216
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317216
    reference: chr 22
allele count: 17
allele frequency: 1.40686550365785e-4
allele num: 120836
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.638C>T
  hgvsp: ENST00000457270.1:c.638C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*70C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.52C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1254C>T
  hgvsp: ENST00000357179.5:c.1254C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.441C>T
  hgvsp: ENST00000413067.2:c.441C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1254C>T
  hgvsp: ENST00000398793.2:c.1254C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*946C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*946C>T
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 1805
  bin: 3.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 5.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 12032
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 33019
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 237
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 75
  bin: 5.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 184
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 421
  bin: 4.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 12531
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 39
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 204
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16
  bin: 9.75e1
  variant carriers: 8
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 7.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.25e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 53
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 18
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 11
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2011
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 354
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 31
  bin: 3.25e1
  variant carriers: 0
hgvs: p.Ala418Ala
num of homozygotes: 0
population: Other
population: European (Non-Finnish)
population: African
population: Latino
population: South Asian
population: European (Finnish)
population: East Asian
reference allele: G
site quality: FS
site quality: InbreedingCoeff
site quality: ReadPosRankSum
site quality: MQRankSum
site quality: ClippingRankSum
site quality: DP
site quality: VQSLOD
site quality: QD
site quality: BaseQRankSum
site quality: MQ

22-22317218-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317218
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317218
    reference: chr 22
allele count: 2
allele frequency: 1.655437283758505e-5
allele num: 120814
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*944G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*68G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1252G>A
  hgvsp: ENSP00000349705.5:p.Ala418Thr
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.439G>A
  hgvsp: ENSP00000393118.2:p.Ala147Thr
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*944G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1252G>A
  hgvsp: ENSP00000381773.2:p.Ala418Thr
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.50G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.636G>A
  hgvsp: ENSP00000408282.1:p.Ala213Thr
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 6.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 73
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 0
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1804
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 33024
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 38
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12026
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 183
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 30
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 420
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 58
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 245
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12521
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 220
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 8.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 684
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 199
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 42
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 25
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 11
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 21
  bin: 3.75e1
  variant carriers: 0
hgvs: p.Ala418Thr
num of homozygotes: 0
population: African
population: East Asian
population: South Asian
population: European (Non-Finnish)
population: Latino
population: European (Finnish)
population: Other
reference allele: C
site quality: FS
site quality: InbreedingCoeff
site quality: BaseQRankSum
site quality: MQRankSum
site quality: VQSLOD
site quality: ReadPosRankSum
site quality: ClippingRankSum
site quality: QD
site quality: MQ
site quality: DP

22-22317219-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317219
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317219
    reference: chr 22
allele count: 1
allele frequency: 8.277049397430804e-6
allele num: 120816
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*943C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1251C>T
  hgvsp: ENST00000357179.5:c.1251C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1251C>T
  hgvsp: ENST00000398793.2:c.1251C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*943C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.49C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.438C>T
  hgvsp: ENST00000413067.2:c.438C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*67C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.635C>T
  hgvsp: ENST00000457270.1:c.635C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 228
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 418
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 57
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12025
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 38
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 0
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 33021
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12521
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 30
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 250
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 184
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1799
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 73
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 26
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 10
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 6
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 685
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 38
  bin: 3.25e1
  variant carriers: 0
hgvs: p.Ile417Ile
num of homozygotes: 0
population: African
population: Other
population: South Asian
population: European (Non-Finnish)
population: East Asian
population: Latino
population: European (Finnish)
reference allele: G
site quality: QD
site quality: MQRankSum
site quality: ClippingRankSum
site quality: ReadPosRankSum
site quality: InbreedingCoeff
site quality: DP
site quality: VQSLOD
site quality: MQ
site quality: BaseQRankSum
site quality: FS

22-22317226-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317226
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317226
    reference: chr 22
allele count: 1
allele frequency: 8.287613333112331e-6
allele num: 120662
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1244A>G
  hgvsp: ENSP00000349705.5:p.His415Arg
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.628A>G
  hgvsp: ENSP00000408282.1:p.His210Arg
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.42A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.431A>G
  hgvsp: ENSP00000393118.2:p.His144Arg
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*936A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*936A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1244A>G
  hgvsp: ENSP00000381773.2:p.His415Arg
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*60A>G
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 73
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 183
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12495
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 0
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 49
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 101
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 309
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11960
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1796
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 417
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 297
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32935
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 30
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 12
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 487
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 71
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2001
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 685
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 58
  bin: 7.5e0
  variant carriers: 0
hgvs: p.His415Arg
num of homozygotes: 0
population: East Asian
population: Other
population: European (Finnish)
population: South Asian
population: European (Non-Finnish)
population: African
population: Latino
reference allele: T
site quality: FS
site quality: ReadPosRankSum
site quality: ClippingRankSum
site quality: VQSLOD
site quality: QD
site quality: BaseQRankSum
site quality: DP
site quality: InbreedingCoeff
site quality: MQRankSum
site quality: MQ

22-22317227-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317227
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317227
    reference: chr 22
allele count: 1
allele frequency: 8.287613333112331e-6
allele num: 120662
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1243C>T
  hgvsp: ENSP00000349705.5:p.His415Tyr
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*59C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.627C>T
  hgvsp: ENSP00000408282.1:p.His210Tyr
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*935C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.430C>T
  hgvsp: ENSP00000393118.2:p.His144Tyr
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.41C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1243C>T
  hgvsp: ENSP00000381773.2:p.His415Tyr
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*935C>T
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 310
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 73
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 100
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11964
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12495
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32931
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 30
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 296
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 18
  bin: 6.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 183
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 50
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 0
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 417
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1796
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 197
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 493
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 72
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 7
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 684
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 18
  bin: 4.75e1
  variant carriers: 0
hgvs: p.His415Tyr
num of homozygotes: 0
population: Latino
population: Other
population: European (Non-Finnish)
population: African
population: East Asian
population: European (Finnish)
population: South Asian
reference allele: G
site quality: VQSLOD
site quality: InbreedingCoeff
site quality: FS
site quality: MQ
site quality: QD
site quality: BaseQRankSum
site quality: MQRankSum
site quality: ClippingRankSum
site quality: DP
site quality: ReadPosRankSum

22-22317230-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317230
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317230
    reference: chr 22
allele count: 1
allele frequency: 8.288437629506838e-6
allele num: 120650
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.624A>G
  hgvsp: ENSP00000408282.1:p.Arg209Gly
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*56A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*932A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1240A>G
  hgvsp: ENSP00000349705.5:p.Arg414Gly
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1240A>G
  hgvsp: ENSP00000381773.2:p.Arg414Gly
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.427A>G
  hgvsp: ENSP00000393118.2:p.Arg143Gly
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.38A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*932A>G
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 1795
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 305
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 50
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32925
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 320
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12487
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 412
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 73
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11961
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 105
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 7.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 183
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 0
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 56
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 57
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 197
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 517
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 13
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1998
  bin: 7.25e1
  variant carriers: 0
hgvs: p.Arg414Gly
num of homozygotes: 0
population: European (Non-Finnish)
population: Other
population: African
population: European (Finnish)
population: Latino
population: East Asian
population: South Asian
reference allele: T
site quality: DP
site quality: MQRankSum
site quality: BaseQRankSum
site quality: ReadPosRankSum
site quality: VQSLOD
site quality: ClippingRankSum
site quality: FS
site quality: QD
site quality: MQ
site quality: InbreedingCoeff

22-22317230-T-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317230
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317230
    reference: chr 22
allele count: 1
allele frequency: 8.288437629506838e-6
allele num: 120650
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.624A>C
  hgvsp: ENST00000457270.1:c.624A>C(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.427A>C
  hgvsp: ENST00000413067.2:c.427A>C(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*932A>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*56A>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1240A>C
  hgvsp: ENST00000398793.2:c.1240A>C(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*932A>C
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1240A>C
  hgvsp: ENST00000357179.5:c.1240A>C(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.38A>C
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 320
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 0
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 73
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12487
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 412
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 50
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 183
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1795
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 305
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11961
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 6.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 105
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32925
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 682
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9265
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 197
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1817
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 18
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 19
  bin: 5.75e1
  variant carriers: 0
hgvs: p.Arg414Arg
num of homozygotes: 0
population: Other
population: Latino
population: East Asian
population: South Asian
population: African
population: European (Finnish)
population: European (Non-Finnish)
reference allele: T
site quality: DP
site quality: ClippingRankSum
site quality: VQSLOD
site quality: MQ
site quality: FS
site quality: BaseQRankSum
site quality: InbreedingCoeff
site quality: QD
site quality: MQRankSum
site quality: ReadPosRankSum

22-22317233-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317233
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317233
    reference: chr 22
allele count: 2
allele frequency: 1.658952537367906e-5
allele num: 120558
alternate allele: C
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1237A>G
  hgvsp: ENSP00000381773.2:p.Thr413Ala
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.621A>G
  hgvsp: ENSP00000408282.1:p.Thr208Ala
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.35A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*929A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*929A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1237A>G
  hgvsp: ENSP00000349705.5:p.Thr413Ala
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.424A>G
  hgvsp: ENSP00000393118.2:p.Thr142Ala
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*53A>G
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 181
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 56
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 7.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 127
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32868
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11964
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12478
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 336
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 410
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1793
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 0
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 336
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 71
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 26
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 40
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 45155
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 15
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 191
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 675
  bin: 8.25e1
  variant carriers: 0
hgvs: p.Thr413Ala
num of homozygotes: 0
population: African
population: Other
population: South Asian
population: European (Non-Finnish)
population: European (Finnish)
population: Latino
population: East Asian
reference allele: T
site quality: MQ
site quality: FS
site quality: ReadPosRankSum
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: QD
site quality: InbreedingCoeff
site quality: VQSLOD
site quality: MQRankSum
site quality: DP

22-22317240-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317240
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317240
    reference: chr 22
allele count: 7
allele frequency: 5.821496290875221e-5
allele num: 120244
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1230G>A
  hgvsp: ENST00000357179.5:c.1230G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*46G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.417G>A
  hgvsp: ENST00000413067.2:c.417G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1230G>A
  hgvsp: ENST00000398793.2:c.1230G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*922G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.614G>A
  hgvsp: ENST00000457270.1:c.614G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.28G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*922G>A
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 32684
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 546
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 0
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11889
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 25
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 7.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 12334
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 222
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 68
  bin: 5.25e1
  variant carriers: 4
genotype depth: GenotypeDepth
  all individuals: 1746
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 397
  bin: 4.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 93
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 468
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 8.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 179
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 789
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1954
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 127
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1774
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 44722
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 62
  bin: 4.25e1
  variant carriers: 0
hgvs: p.Glu410Glu
num of homozygotes: 0
population: Other
population: European (Finnish)
population: East Asian
population: European (Non-Finnish)
population: South Asian
population: Latino
population: African
reference allele: C
site quality: MQRankSum
site quality: DP
site quality: ReadPosRankSum
site quality: FS
site quality: MQ
site quality: ClippingRankSum
site quality: VQSLOD
site quality: BaseQRankSum
site quality: InbreedingCoeff
site quality: QD

22-22317244-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317244
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317244
    reference: chr 22
allele count: 1
allele frequency: 8.326117364950376e-6
allele num: 120104
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1226A>G
  hgvsp: ENSP00000349705.5:p.Tyr409Cys
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*42A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1226A>G
  hgvsp: ENSP00000381773.2:p.Tyr409Cys
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.413A>G
  hgvsp: ENSP00000393118.2:p.Tyr138Cys
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*918A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.24A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*918A>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.610A>G
  hgvsp: ENSP00000408282.1:p.Tyr204Cys
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 238
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 605
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 63
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 25
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1727
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 524
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 105
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32631
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 394
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 168
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11916
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 7.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12255
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 0
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 59
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 61
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 110
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 95
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 429
  bin: 9.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 879
  bin: 2.25e1
  variant carriers: 0
hgvs: p.Tyr409Cys
num of homozygotes: 0
population: European (Finnish)
population: European (Non-Finnish)
population: East Asian
population: South Asian
population: African
population: Other
population: Latino
reference allele: T
site quality: BaseQRankSum
site quality: ReadPosRankSum
site quality: InbreedingCoeff
site quality: FS
site quality: MQ
site quality: ClippingRankSum
site quality: DP
site quality: VQSLOD
site quality: QD
site quality: MQRankSum

22-22317246-G-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317246
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317246
    reference: chr 22
allele count: 2
allele frequency: 1.667889785842951e-5
allele num: 119912
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*916C>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.608C>G
  hgvsp: ENST00000457270.1:c.608C>G(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.22C>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1224C>G
  hgvsp: ENST00000398793.2:c.1224C>G(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*916C>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1224C>G
  hgvsp: ENST00000357179.5:c.1224C>G(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.411C>G
  hgvsp: ENST00000413067.2:c.411C>G(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*40C>G
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 25
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 692
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 621
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 0
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11902
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 108
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 387
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12183
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1697
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 279
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 167
  bin: 4.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 6.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 32528
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 63
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 47
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 9033
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 167
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 140
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 21
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1038
  bin: 2.25e1
  variant carriers: 0
hgvs: p.Leu408Leu
num of homozygotes: 0
population: Latino
population: East Asian
population: South Asian
population: African
population: European (Finnish)
population: Other
population: European (Non-Finnish)
reference allele: G
site quality: ReadPosRankSum
site quality: DP
site quality: ClippingRankSum
site quality: FS
site quality: BaseQRankSum
site quality: InbreedingCoeff
site quality: QD
site quality: MQRankSum
site quality: MQ
site quality: VQSLOD

22-22317251-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317251
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317251
    reference: chr 22
allele count: 1
allele frequency: 8.36456102783726e-6
allele num: 119552
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.603C>T
  hgvsp: ENSP00000408282.1:p.Arg202Trp
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.17C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1219C>T
  hgvsp: ENSP00000349705.5:p.Arg407Trp
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*911C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1219C>T
  hgvsp: ENSP00000381773.2:p.Arg407Trp
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.406C>T
  hgvsp: ENSP00000393118.2:p.Arg136Trp
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*35C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*911C>T
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 25
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 767
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 376
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 866
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 63
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 126
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32335
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11984
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 165
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11931
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 374
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 6.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 0
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1642
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 182
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8879
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 142
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 188
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 214
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 76
  bin: 4.25e1
  variant carriers: 0
hgvs: p.Arg407Trp
num of homozygotes: 0
population: South Asian
population: European (Non-Finnish)
population: East Asian
population: African
population: Latino
population: European (Finnish)
population: Other
reference allele: G
site quality: VQSLOD
site quality: BaseQRankSum
site quality: DP
site quality: FS
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: ClippingRankSum
site quality: MQ
site quality: QD
site quality: ReadPosRankSum

22-22317255-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317255
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317255
    reference: chr 22
allele count: 10
allele frequency: 8.38335401227323e-5
allele num: 119284
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*907G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1215G>A
  hgvsp: ENST00000398793.2:c.1215G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*31G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*907G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1215G>A
  hgvsp: ENST00000357179.5:c.1215G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.402G>A
  hgvsp: ENST00000413067.2:c.402G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.599G>A
  hgvsp: ENST00000457270.1:c.599G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.13G>A
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 1059
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 159
  bin: 4.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 11700
  bin: 3.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 901
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 137
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 359
  bin: 4.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26
  bin: 5.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 439
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1580
  bin: 3.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 12117
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32116
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 6.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 61
  bin: 5.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 0
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 635
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1566
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 139
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 167
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1719
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 167
  bin: 4.75e1
  variant carriers: 0
hgvs: p.Ala405Ala
num of homozygotes: 0
population: European (Non-Finnish)
population: Latino
population: South Asian
population: Other
population: African
population: East Asian
population: European (Finnish)
reference allele: C
site quality: QD
site quality: VQSLOD
site quality: ReadPosRankSum
site quality: InbreedingCoeff
site quality: MQRankSum
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: MQ
site quality: FS
site quality: DP

22-22317256-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317256
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317256
    reference: chr 22
allele count: 12
allele frequency: 1.006086825293023e-4
allele num: 119274
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.401C>T
  hgvsp: ENSP00000393118.2:p.Ala134Val
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*906C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1214C>T
  hgvsp: ENSP00000381773.2:p.Ala405Val
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.12C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*906C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.598C>T
  hgvsp: ENSP00000408282.1:p.Ala200Val
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1214C>T
  hgvsp: ENSP00000349705.5:p.Ala405Val
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*30C>T
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32140
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 432
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 8.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 1567
  bin: 3.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 137
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1064
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 56
  bin: 5.25e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 11666
  bin: 3.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 12159
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 154
  bin: 4.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 907
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 6.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 0
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 350
  bin: 4.25e1
  variant carriers: 2
genotype quality: GenotypeQuality
  all individuals: 43948
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 10
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8782
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 264
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1577
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 162
  bin: 4.75e1
  variant carriers: 0
hgvs: p.Ala405Val
num of homozygotes: 0
population: East Asian
population: European (Finnish)
population: African
population: Latino
population: Other
population: South Asian
population: European (Non-Finnish)
reference allele: G
site quality: FS
site quality: QD
site quality: InbreedingCoeff
site quality: MQ
site quality: MQRankSum
site quality: VQSLOD
site quality: ReadPosRankSum
site quality: DP
site quality: ClippingRankSum
site quality: BaseQRankSum

22-22317257-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317257
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317257
    reference: chr 22
allele count: 3
allele frequency: 2.516271891565457e-5
allele num: 119224
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*905G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*905G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.400G>A
  hgvsp: ENSP00000393118.2:p.Ala134Thr
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*29G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.597G>A
  hgvsp: ENSP00000408282.1:p.Ala200Thr
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1213G>A
  hgvsp: ENSP00000381773.2:p.Ala405Thr
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1213G>A
  hgvsp: ENSP00000349705.5:p.Ala405Thr
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.11G>A
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 139
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12178
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32080
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 454
  bin: 1.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11635
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 152
  bin: 4.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 1557
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 344
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1110
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 52
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 934
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 0
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 85
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 43884
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 625
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1871
  bin: 7.25e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 13
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8747
  bin: 6.75e1
  variant carriers: 0
hgvs: p.Ala405Thr
num of homozygotes: 0
population: East Asian
population: Latino
population: European (Non-Finnish)
population: South Asian
population: African
population: European (Finnish)
population: Other
reference allele: C
site quality: FS
site quality: ReadPosRankSum
site quality: MQRankSum
site quality: MQ
site quality: VQSLOD
site quality: ClippingRankSum
site quality: InbreedingCoeff
site quality: QD
site quality: BaseQRankSum
site quality: DP

22-22317258-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317258
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317258
    reference: chr 22
allele count: 24
allele frequency: 2.016264533906849e-4
allele num: 119032
alternate allele: A
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1212C>T
  hgvsp: ENST00000398793.2:c.1212C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1212C>T
  hgvsp: ENST00000357179.5:c.1212C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000100038
  ensembl transcript: ENST00000470338
  gene symbol: TOP3B
  hgvsc: ENST00000470338.1:n.10C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*904C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.399C>T
  hgvsp: ENST00000413067.2:c.399C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*904C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*28C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.596C>T
  hgvsp: ENST00000457270.1:c.596C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 153
  bin: 4.75e1
  variant carriers: 4
genotype depth: GenotypeDepth
  all individuals: 1220
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 24
  bin: 5.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 31895
  bin: 2.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 51
  bin: 5.25e1
  variant carriers: 4
genotype depth: GenotypeDepth
  all individuals: 1527
  bin: 3.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 148
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 0
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11530
  bin: 3.25e1
  variant carriers: 4
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 6.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1012
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 504
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 6.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 7.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 12260
  bin: 2.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 334
  bin: 4.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 55
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 238
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 16
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 167
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1787
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 301
  bin: 3.25e1
  variant carriers: 0
hgvs: p.Asp404Asp
num of homozygotes: 1
population: European (Finnish)
population: Latino
population: Other
population: African
population: South Asian
population: East Asian
population: European (Non-Finnish)
reference allele: G
site quality: QD
site quality: ReadPosRankSum
site quality: BaseQRankSum
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: MQ
site quality: DP
site quality: VQSLOD
site quality: FS
site quality: ClippingRankSum

22-22317268-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317268
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317268
    reference: chr 22
allele count: 1
allele frequency: 8.447801037389967e-6
allele num: 118374
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.392-3C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.589-3C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*897-3C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1205-3C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*897-3C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1205-3C>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*18C>T
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: splice region
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 181
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12549
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 546
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1641
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1304
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1416
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 131
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31460
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11084
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 0
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 290
  bin: 4.25e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 216
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 101
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 30
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2425
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 178
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 130
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 143
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 346
  bin: 3.25e1
  variant carriers: 0
hgvs: c.1205-3C>T
num of homozygotes: 0
population: Other
population: South Asian
population: East Asian
population: African
population: European (Finnish)
population: Latino
population: European (Non-Finnish)
reference allele: G
site quality: ReadPosRankSum
site quality: InbreedingCoeff
site quality: MQ
site quality: ClippingRankSum
site quality: FS
site quality: VQSLOD
site quality: QD
site quality: BaseQRankSum
site quality: MQRankSum
site quality: DP

http://identifiers.org/exac.variant/22-22317272-C-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317272
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317272
    reference: chr 22
allele count: 1
allele frequency: 8.493723138600575e-6
allele num: 117734
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*897-7G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*14G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.589-7G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.392-7G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*897-7G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1205-7G>T
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1205-7G>T
  variant of: http://identifiers.org/hgnc/11993
canonical: true
consequence: splice region
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 663
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1391
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31035
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 209
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1579
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 127
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10952
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12214
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 284
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 0
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2146
  bin: 1.25e1
  variant carriers: 1
genotype quality: GenotypeQuality
  all individuals: 49
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 17
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8336
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 50
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 42769
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 237
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 245
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 126
  bin: 9.25e1
  variant carriers: 0
hgvs: c.1205-7G>T
num of homozygotes: 0
population: Latino
population: European (Finnish)
population: South Asian
population: Other
population: European (Non-Finnish)
population: East Asian
population: African
reference allele: C
site quality: MQRankSum
site quality: VQSLOD
site quality: InbreedingCoeff
site quality: FS
site quality: DP
site quality: MQ
site quality: BaseQRankSum
site quality: ReadPosRankSum
site quality: ClippingRankSum
site quality: QD

22-22317275-G-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317275
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317275
    reference: chr 22
allele count: 2
allele frequency: 1.7080877957127e-5
allele num: 117090
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.392-10C>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*897-10C>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1205-10C>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*11C>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*897-10C>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.589-10C>G
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1205-10C>G
  variant of: http://identifiers.org/hgnc/11993
canonical: false
consequence: 3' UTR
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 10831
  bin: 3.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 1855
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12001
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 756
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 238
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 277
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 30616
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2540
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1360
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 0
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 6.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 126
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 61
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3588
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1464
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 123
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 507
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 137
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 23
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 302
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 271
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 244
  bin: 7.5e0
  variant carriers: 0
num of homozygotes: 0
population: East Asian
population: Other
population: African
population: Latino
population: European (Non-Finnish)
population: European (Finnish)
population: South Asian
reference allele: G
site quality: FS
site quality: MQRankSum
site quality: DP
site quality: ReadPosRankSum
site quality: MQ
site quality: QD
site quality: ClippingRankSum
site quality: InbreedingCoeff
site quality: VQSLOD
site quality: BaseQRankSum

22-22317276-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 22317276
    reference: chr 22
  end: Position
    type: ExactPosition
    position: 22317276
    reference: chr 22
allele count: 1
allele frequency: 8.540730744922536e-6
allele num: 117086
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000392480
  ensembl transcript: ENST00000444502
  gene symbol: TOP3B
  hgvsc: ENST00000444502.1:c.*897-11G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000397221
  ensembl transcript: ENST00000457179
  gene symbol: TOP3B
  hgvsc: ENST00000457179.1:c.*897-11G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000381773
  ensembl transcript: ENST00000398793
  gene symbol: TOP3B
  hgvsc: ENST00000398793.2:c.1205-11G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: 3_prime_UTR_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000416451
  ensembl transcript: ENST00000436282
  gene symbol: TOP3B
  hgvsc: ENST00000436282.1:c.*10G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000393118
  ensembl transcript: ENST00000413067
  gene symbol: TOP3B
  hgvsc: ENST00000413067.2:c.392-11G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000408282
  ensembl transcript: ENST00000457270
  gene symbol: TOP3B
  hgvsc: ENST00000457270.1:c.589-11G>A
  variant of: http://identifiers.org/hgnc/11993
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000100038
  ensembl protein: ENSP00000349705
  ensembl transcript: ENST00000357179
  gene symbol: TOP3B
  hgvsc: ENST00000357179.5:c.1205-11G>A
  variant of: http://identifiers.org/hgnc/11993
canonical: false
consequence: 3' UTR
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 0
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 749
  bin: 1.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 12023
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1869
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 30639
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10769
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 242
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2556
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1355
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 125
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 274
  bin: 4.25e1
  variant carriers: 0
num of homozygotes: 0
reference allele: C

GenotypeQuality
all individuals: 505
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 304
bin: 4.75e1
variant carriers: 0

GenotypeQuality
all individuals: 43736
bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 2021
bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 594
bin: 3.25e1
variant carriers: 0

GenotypeQuality
all individuals: 38
bin: 1.75e1
variant carriers: 0

GenotypeQuality
all individuals: 365
bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 1474
bin: 2.25e1
variant carriers: 0

GenotypeQuality
all individuals: 6571
bin: 6.75e1
variant carriers: 0

GenotypeQuality
all individuals: 1954
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 192
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1043
bin: 8.25e1
variant carriers: 0

GenotypeQuality
all individuals: 549
bin: 9.75e1
variant carriers: 1

GenotypeQuality
all individuals: 334
bin: 9.25e1
variant carriers: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11488
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 888
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 65722
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6446
num of homozygotes: 0

African
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allele count: 0
allele frequency: 0.0e0
allele num: 10238
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8610
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.067224851352991e-5
allele num: 16482
num of homozygotes: 0

FS
type: SiteQuality
SIO_000300: 1.561e0

QD
type: SiteQuality
SIO_000300: 1.185e1

MQ
type: SiteQuality
SIO_000300: 5.925e1

InbreedingCoeff
type: SiteQuality
SIO_000300: -1.0e-3

DP
type: SiteQuality
SIO_000300: 1.414358e6

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.33e0

ClippingRankSum
type: SiteQuality
SIO_000300: -1.489e0

MQRankSum
type: SiteQuality
SIO_000300: 1.09e0

BaseQRankSum
type: SiteQuality
SIO_000300: -6.0e-2

VQSLOD
type: SiteQuality
SIO_000300: 9.0e-2

GenotypeQuality
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bin: 5.75e1
variant carriers: 0

GenotypeQuality
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bin: 7.75e1
variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 382
bin: 4.75e1
variant carriers: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10214
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 65632
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8606
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6426
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16478
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 888
num of homozygotes: 0

Latino
type: Population
allele count: 2
allele frequency: 1.741250217656277e-4
allele num: 11486
num of homozygotes: 0

MQRankSum
type: SiteQuality
SIO_000300: 8.0e-2

QD
type: SiteQuality
SIO_000300: 8.33e0

InbreedingCoeff
type: SiteQuality
SIO_000300: -1.0e-3

FS
type: SiteQuality
SIO_000300: 2.063e0

DP
type: SiteQuality
SIO_000300: 1.409789e6

BaseQRankSum
type: SiteQuality
SIO_000300: -4.186e0

VQSLOD
type: SiteQuality
SIO_000300: 9.3e-2

ReadPosRankSum
type: SiteQuality
SIO_000300: 5.570000000000001e-1

MQ
type: SiteQuality
SIO_000300: 6.0e1

ClippingRankSum
type: SiteQuality
SIO_000300: 9.07e-1

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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variant carriers: 0

African
type: Population
allele count: 2
allele frequency: 1.961553550411926e-4
allele num: 10196
num of homozygotes: 0

East Asian
type: Population
allele count: 1
allele frequency: 1.162520344106022e-4
allele num: 8602
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 888
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11484
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6420
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16476
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 5
allele frequency: 7.620324930655044e-5
allele num: 65614
num of homozygotes: 0

MQRankSum
type: SiteQuality
SIO_000300: -2.73e-1

BaseQRankSum
type: SiteQuality
SIO_000300: 1.68e0

VQSLOD
type: SiteQuality
SIO_000300: 4.34e-1

ClippingRankSum
type: SiteQuality
SIO_000300: -4.79e-1

FS
type: SiteQuality
SIO_000300: 5.71e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: -1.0e-3

MQ
type: SiteQuality
SIO_000300: 6.0e1

QD
type: SiteQuality
SIO_000300: 9.210000000000001e0

DP
type: SiteQuality
SIO_000300: 1.410249e6

ReadPosRankSum
type: SiteQuality
SIO_000300: 5.69e-1

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 9.25e1
variant carriers: 0

Latino
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allele count: 0
allele frequency: 0.0e0
allele num: 11474
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8586
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16428
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10168
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 882
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6396
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.528631263566603e-5
allele num: 65418
num of homozygotes: 0

ClippingRankSum
type: SiteQuality
SIO_000300: 4.61e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: -1.0e-4

MQRankSum
type: SiteQuality
SIO_000300: 1.63e0

MQ
type: SiteQuality
SIO_000300: 6.0e1

DP
type: SiteQuality
SIO_000300: 1.394988e6

FS
type: SiteQuality
SIO_000300: 9.86e-1

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.44e0

VQSLOD
type: SiteQuality
SIO_000300: 4.57e-1

QD
type: SiteQuality
SIO_000300: 1.509e1

BaseQRankSum
type: SiteQuality
SIO_000300: 3.2e0

GenotypeQuality
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bin: 3.75e1
variant carriers: 0

GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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variant carriers: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.529894131326112e-5
allele num: 65364
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16416
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 882
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11466
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6386
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10152
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8582
num of homozygotes: 0

QD
type: SiteQuality
SIO_000300: 1.034e1

BaseQRankSum
type: SiteQuality
SIO_000300: -4.58e-1

FS
type: SiteQuality
SIO_000300: 1.9434e1

ReadPosRankSum
type: SiteQuality
SIO_000300: -2.46e-1

MQRankSum
type: SiteQuality
SIO_000300: 3.85e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: -1.0e-4

VQSLOD
type: SiteQuality
SIO_000300: -2.958e0

ClippingRankSum
type: SiteQuality
SIO_000300: 3.72e-1

DP
type: SiteQuality
SIO_000300: 1.391243e6

MQ
type: SiteQuality
SIO_000300: 5.915e1

GenotypeQuality
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bin: 6.75e1
variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 1

GenotypeQuality
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bin: 6.25e1
variant carriers: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 878
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8582
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.094588005850804e-5
allele num: 16408
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 65272
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11456
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10150
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6374
num of homozygotes: 0

ClippingRankSum
type: SiteQuality
SIO_000300: -5.0e-2

ReadPosRankSum
type: SiteQuality
SIO_000300: -1.16e-1

VQSLOD
type: SiteQuality
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MQ
type: SiteQuality
SIO_000300: 6.0e1

FS
type: SiteQuality
SIO_000300: 1.966e0

DP
type: SiteQuality
SIO_000300: 1.387797e6

InbreedingCoeff
type: SiteQuality
SIO_000300: 2.1e-3

MQRankSum
type: SiteQuality
SIO_000300: -4.4e-2

BaseQRankSum
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QD
type: SiteQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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variant carriers: 2

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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bin: 6.75e1
variant carriers: 0

GenotypeQuality
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bin: 7.25e1
variant carriers: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11456
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8582
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6374
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 878
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 65272
num of homozygotes: 0

African
type: Population
allele count: 2
allele frequency: 1.970443349753695e-4
allele num: 10150
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

FS
type: SiteQuality
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MQRankSum
type: SiteQuality
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QD
type: SiteQuality
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ReadPosRankSum
type: SiteQuality
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MQ
type: SiteQuality
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VQSLOD
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ClippingRankSum
type: SiteQuality
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DP
type: SiteQuality
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InbreedingCoeff
type: SiteQuality
SIO_000300: 2.1e-3

BaseQRankSum
type: SiteQuality
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GenotypeQuality
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bin: 1.25e1
variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 7.5e0
variant carriers: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11448
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.535909565644775e-5
allele num: 65108
num of homozygotes: 0

African
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allele frequency: 0.0e0
allele num: 10114
num of homozygotes: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
allele num: 8566
num of homozygotes: 0

South Asian
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allele count: 0
allele frequency: 0.0e0
allele num: 16374
num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 6364
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

QD
type: SiteQuality
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BaseQRankSum
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VQSLOD
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MQRankSum
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DP
type: SiteQuality
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FS
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MQ
type: SiteQuality
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ClippingRankSum
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InbreedingCoeff
type: SiteQuality
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ReadPosRankSum
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 8.75e1
variant carriers: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6358
num of homozygotes: 0

African
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allele count: 0
allele frequency: 0.0e0
allele num: 10080
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16344
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.539408866995074e-5
allele num: 64960
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8556
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11448
num of homozygotes: 0

Other
type: Population
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allele frequency: 0.0e0
allele num: 874
num of homozygotes: 0

InbreedingCoeff
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MQ
type: SiteQuality
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ClippingRankSum
type: SiteQuality
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BaseQRankSum
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ReadPosRankSum
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DP
type: SiteQuality
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VQSLOD
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FS
type: SiteQuality
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MQRankSum
type: SiteQuality
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QD
type: SiteQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 2.5e0
variant carriers: 0

GenotypeQuality
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bin: 8.25e1
variant carriers: 0

GenotypeQuality
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bin: 3.75e1
variant carriers: 0

GenotypeQuality
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bin: 9.25e1
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GenotypeQuality
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bin: 5.75e1
variant carriers: 0

GenotypeQuality
all individuals: 2076
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 2135
bin: 7.25e1
variant carriers: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10012
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6342
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11434
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 64728
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8544
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 874
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.12369871402327e-5
allele num: 16330
num of homozygotes: 0

ReadPosRankSum
type: SiteQuality
SIO_000300: -6.32e-1

MQRankSum
type: SiteQuality
SIO_000300: -1.007e0

InbreedingCoeff
type: SiteQuality
SIO_000300: -8.0e-4

FS
type: SiteQuality
SIO_000300: 3.12e0

QD
type: SiteQuality
SIO_000300: 2.062e1

DP
type: SiteQuality
SIO_000300: 1.370571e6

ClippingRankSum
type: SiteQuality
SIO_000300: 1.08e0

VQSLOD
type: SiteQuality
SIO_000300: -2.098e0

BaseQRankSum
type: SiteQuality
SIO_000300: -8.500000000000001e-2

MQ
type: SiteQuality
SIO_000300: 6.0e1

GenotypeQuality
all individuals: 2097
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 1461
bin: 5.25e1
variant carriers: 0

GenotypeQuality
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bin: 7.5e0
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GenotypeQuality
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bin: 1.75e1
variant carriers: 0

GenotypeQuality
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bin: 2.75e1
variant carriers: 0

GenotypeQuality
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bin: 6.75e1
variant carriers: 0

GenotypeQuality
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bin: 9.25e1
variant carriers: 2

GenotypeQuality
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bin: 6.25e1
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GenotypeQuality
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variant carriers: 1

GenotypeQuality
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bin: 5.75e1
variant carriers: 0

GenotypeQuality
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bin: 9.75e1
variant carriers: 147

GenotypeQuality
all individuals: 1951
bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 403
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variant carriers: 1

South Asian
type: Population
allele count: 13
allele frequency: 7.960808328230251e-4
allele num: 16330
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 114
allele frequency: 1.760889712696942e-3
allele num: 64740
num of homozygotes: 0

African
type: Population
allele count: 4
allele frequency: 3.999200159968006e-4
allele num: 10002
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8544
num of homozygotes: 0

Other
type: Population
allele count: 3
allele frequency: 3.432494279176201e-3
allele num: 874
num of homozygotes: 0

Latino
type: Population
allele count: 17
allele frequency: 1.486013986013986e-3
allele num: 11440
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6344
num of homozygotes: 0

VQSLOD
type: SiteQuality
SIO_000300: -3.741e0

ReadPosRankSum
type: SiteQuality
SIO_000300: -3.58e-1

FS
type: SiteQuality
SIO_000300: 2.6723e1

MQRankSum
type: SiteQuality
SIO_000300: 2.55e-1

DP
type: SiteQuality
SIO_000300: 1.37094e6

MQ
type: SiteQuality
SIO_000300: 6.0e1

QD
type: SiteQuality
SIO_000300: 1.183e1

InbreedingCoeff
type: SiteQuality
SIO_000300: 3.0e-4

BaseQRankSum
type: SiteQuality
SIO_000300: 3.23e0

ClippingRankSum
type: SiteQuality
SIO_000300: 6.11e-1

GenotypeQuality
all individuals: 2179
bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1660
bin: 4.75e1
variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
all individuals: 33329
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
all individuals: 2123
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 582
bin: 9.75e1
variant carriers: 4

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 64712
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11434
num of homozygotes: 0

African
type: Population
allele count: 3
allele frequency: 3.004205888243541e-4
allele num: 9986
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 874
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16310
num of homozygotes: 0

East Asian
type: Population
allele count: 1
allele frequency: 1.170686022008897e-4
allele num: 8542
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6342
num of homozygotes: 0

DP
type: SiteQuality
SIO_000300: 1.370589e6

MQRankSum
type: SiteQuality
SIO_000300: -1.07e-1

BaseQRankSum
type: SiteQuality
SIO_000300: 8.5e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: -5.0e-4

FS
type: SiteQuality
SIO_000300: 6.117e0

VQSLOD
type: SiteQuality
SIO_000300: 2.96e-1

ClippingRankSum
type: SiteQuality
SIO_000300: -2.83e-1

QD
type: SiteQuality
SIO_000300: 1.323e1

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.27e0

MQ
type: SiteQuality
SIO_000300: 5.897e1

GenotypeQuality
all individuals: 1679
bin: 5.25e1
variant carriers: 0

GenotypeQuality
all individuals: 330
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
all individuals: 110
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GenotypeQuality
all individuals: 2891
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
all individuals: 1020
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variant carriers: 0

GenotypeQuality
all individuals: 1231
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 411
bin: 8.75e1
variant carriers: 0

South Asian
type: Population
allele count: 2
allele frequency: 1.231830500123183e-4
allele num: 16236
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8512
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 866
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 2
allele frequency: 3.100294527980158e-5
allele num: 64510
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 9896
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11404
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6300
num of homozygotes: 0

DP
type: SiteQuality
SIO_000300: 1.376024e6

BaseQRankSum
type: SiteQuality
SIO_000300: -4.08e-1

ReadPosRankSum
type: SiteQuality
SIO_000300: 6.51e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: -2.0e-3

VQSLOD
type: SiteQuality
SIO_000300: 2.71e0

FS
type: SiteQuality
SIO_000300: 1.039e0

ClippingRankSum
type: SiteQuality
SIO_000300: -9.15e-1

MQ
type: SiteQuality
SIO_000300: 6.0e1

MQRankSum
type: SiteQuality
SIO_000300: 8.2e-2

QD
type: SiteQuality
SIO_000300: 1.333e1

GenotypeQuality
all individuals: 1996
bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 2275
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variant carriers: 0

GenotypeQuality
all individuals: 1687
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GenotypeQuality
all individuals: 393
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GenotypeQuality
all individuals: 79
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variant carriers: 0

GenotypeQuality
all individuals: 2168
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GenotypeQuality
all individuals: 2262
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variant carriers: 0

GenotypeQuality
all individuals: 645
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variant carriers: 19

GenotypeQuality
all individuals: 1162
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variant carriers: 0

GenotypeQuality
all individuals: 1096
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variant carriers: 0

GenotypeQuality
all individuals: 1543
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variant carriers: 0

GenotypeQuality
all individuals: 6496
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variant carriers: 0

GenotypeQuality
all individuals: 1244
bin: 8.25e1
variant carriers: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11428
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16288
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 872
num of homozygotes: 0

African
type: Population
allele count: 17
allele frequency: 1.710261569416499e-3
allele num: 9940
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 2
allele frequency: 3.096934035305048e-5
allele num: 64580
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6326
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8516
num of homozygotes: 0

QD
type: SiteQuality
SIO_000300: 1.381e1

FS
type: SiteQuality
SIO_000300: 5.23e-1

DP
type: SiteQuality
SIO_000300: 1.376632e6

MQRankSum
type: SiteQuality
SIO_000300: -3.34e-1

ReadPosRankSum
type: SiteQuality
SIO_000300: 4.0e-1

BaseQRankSum
type: SiteQuality
SIO_000300: 8.37e-1

VQSLOD
type: SiteQuality
SIO_000300: 1.77e0

InbreedingCoeff
type: SiteQuality
SIO_000300: -2.3e-3

MQ
type: SiteQuality
SIO_000300: 5.94e1

ClippingRankSum
type: SiteQuality
SIO_000300: -1.2e-2

GenotypeQuality
all individuals: 2365
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 918
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variant carriers: 0

GenotypeQuality
all individuals: 835
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variant carriers: 0

GenotypeQuality
all individuals: 3026
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variant carriers: 0

GenotypeQuality
all individuals: 460
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variant carriers: 0

GenotypeQuality
all individuals: 2066
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
all individuals: 151
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variant carriers: 0

GenotypeQuality
all individuals: 411
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variant carriers: 0

GenotypeQuality
all individuals: 1858
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variant carriers: 0

GenotypeQuality
all individuals: 2360
bin: 7.25e1
variant carriers: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.545356204605162e-5
allele num: 64710
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 874
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6346
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8522
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16266
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 9988
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11440
num of homozygotes: 0

BaseQRankSum
type: SiteQuality
SIO_000300: 3.3e0

VQSLOD
type: SiteQuality
SIO_000300: 8.0e-1

MQRankSum
type: SiteQuality
SIO_000300: -1.7e-2

FS
type: SiteQuality
SIO_000300: 3.426e0

ReadPosRankSum
type: SiteQuality
SIO_000300: 2.48e-1

QD
type: SiteQuality
SIO_000300: 1.082e1

InbreedingCoeff
type: SiteQuality
SIO_000300: -1.8e-3

MQ
type: SiteQuality
SIO_000300: 5.953e1

DP
type: SiteQuality
SIO_000300: 1.382622e6

ClippingRankSum
type: SiteQuality
SIO_000300: 5.0e-2

GenotypeQuality
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variant carriers: 0

GenotypeQuality
all individuals: 674
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variant carriers: 3

GenotypeQuality
all individuals: 416
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GenotypeQuality
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GenotypeQuality
all individuals: 776
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GenotypeQuality
all individuals: 33053
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
all individuals: 939
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GenotypeQuality
all individuals: 1333
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GenotypeQuality
all individuals: 192
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variant carriers: 0

GenotypeQuality
all individuals: 2066
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GenotypeQuality
all individuals: 1271
bin: 4.75e1
variant carriers: 1

African
type: Population
allele count: 1
allele frequency: 1.002204850671477e-4
allele num: 9978
num of homozygotes: 0

East Asian
type: Population
allele count: 1
allele frequency: 1.172882946281961e-4
allele num: 8526
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11424
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 870
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6348
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16232
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 2
allele frequency: 3.093963676866434e-5
allele num: 64642
num of homozygotes: 0

FS
type: SiteQuality
SIO_000300: 5.049e0

VQSLOD
type: SiteQuality
SIO_000300: -3.72e-2

ClippingRankSum
type: SiteQuality
SIO_000300: 1.01e0

QD
type: SiteQuality
SIO_000300: 1.062e1

InbreedingCoeff
type: SiteQuality
SIO_000300: -2.0e-3

DP
type: SiteQuality
SIO_000300: 1.385112e6

BaseQRankSum
type: SiteQuality
SIO_000300: -3.87e-1

MQ
type: SiteQuality
SIO_000300: 5.923e1

MQRankSum
type: SiteQuality
SIO_000300: -5.84e-1

ReadPosRankSum
type: SiteQuality
SIO_000300: -4.56e-1

GenotypeQuality
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bin: 6.75e1
variant carriers: 0

GenotypeQuality
all individuals: 308
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GenotypeQuality
all individuals: 1072
bin: 4.75e1
variant carriers: 0

GenotypeQuality
all individuals: 488
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GenotypeQuality
all individuals: 133
bin: 1.25e1
variant carriers: 0

GenotypeQuality
all individuals: 145
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GenotypeQuality
all individuals: 1584
bin: 2.75e1
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GenotypeQuality
all individuals: 33810
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
all individuals: 2016
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GenotypeQuality
all individuals: 432
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variant carriers: 0

GenotypeQuality
all individuals: 810
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 691
bin: 9.75e1
variant carriers: 3

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11436
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6362
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8534
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 874
num of homozygotes: 0

African
type: Population
allele count: 1
allele frequency: 1.00060036021613e-4
allele num: 9994
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.544687818591863e-5
allele num: 64738
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16234
num of homozygotes: 0

FS
type: SiteQuality
SIO_000300: 3.036e0

ReadPosRankSum
type: SiteQuality
SIO_000300: -9.56e-1

MQ
type: SiteQuality
SIO_000300: 6.0e1

InbreedingCoeff
type: SiteQuality
SIO_000300: -1.6e-3

MQRankSum
type: SiteQuality
SIO_000300: -5.0e-2

BaseQRankSum
type: SiteQuality
SIO_000300: -3.218e0

VQSLOD
type: SiteQuality
SIO_000300: 1.44e0

ClippingRankSum
type: SiteQuality
SIO_000300: 3.22e-1

DP
type: SiteQuality
SIO_000300: 1.386617e6

QD
type: SiteQuality
SIO_000300: 1.268e1

GenotypeQuality
all individuals: 2865
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 1327
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 254
bin: 7.5e0
variant carriers: 0

GenotypeQuality
all individuals: 552
bin: 5.25e1
variant carriers: 0

GenotypeQuality
all individuals: 33
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GenotypeQuality
all individuals: 581
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 2741
bin: 7.25e1
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GenotypeQuality
all individuals: 731
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GenotypeQuality
all individuals: 34614
bin: 6.25e1
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GenotypeQuality
all individuals: 575
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GenotypeQuality
all individuals: 748
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variant carriers: 0

GenotypeQuality
all individuals: 1338
bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 141
bin: 1.75e1
variant carriers: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6380
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16194
num of homozygotes: 0

Latino
type: Population
allele count: 1
allele frequency: 8.733624454148471e-5
allele num: 11450
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 9974
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 64792
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8540
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 870
num of homozygotes: 0

BaseQRankSum
type: SiteQuality
SIO_000300: -2.224e0

MQRankSum
type: SiteQuality
SIO_000300: 9.03e-1

VQSLOD
type: SiteQuality
SIO_000300: 1.32e0

ClippingRankSum
type: SiteQuality
SIO_000300: 4.64e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: -4.0e-4

MQ
type: SiteQuality
SIO_000300: 6.0e1

ReadPosRankSum
type: SiteQuality
SIO_000300: -2.2e-1

FS
type: SiteQuality
SIO_000300: 3.751e0

DP
type: SiteQuality
SIO_000300: 1.408478e6

QD
type: SiteQuality
SIO_000300: 1.021e1

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
all individuals: 766
bin: 9.75e1
variant carriers: 1

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11458
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.540784567501772e-5
allele num: 64902
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6392
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8546
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10004
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16138
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 868
num of homozygotes: 0

DP
type: SiteQuality
SIO_000300: 1.427684e6

QD
type: SiteQuality
SIO_000300: 1.337e1

FS
type: SiteQuality
SIO_000300: 3.511e0

ClippingRankSum
type: SiteQuality
SIO_000300: -2.462e0

InbreedingCoeff
type: SiteQuality
SIO_000300: 3.0e-4

VQSLOD
type: SiteQuality
SIO_000300: 5.97e-1

MQRankSum
type: SiteQuality
SIO_000300: -2.45e-1

BaseQRankSum
type: SiteQuality
SIO_000300: 3.09e-1

MQ
type: SiteQuality
SIO_000300: 5.96e1

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.63e0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 6406
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.213495712687958e-5
allele num: 16094
num of homozygotes: 0

Other
type: Population
allele count: 1
allele frequency: 1.1441647597254e-3
allele num: 874
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 4
allele frequency: 6.164848036495901e-5
allele num: 64884
num of homozygotes: 0

Latino
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allele count: 0
allele frequency: 0.0e0
allele num: 11450
num of homozygotes: 0

East Asian
type: Population
allele count: 2
allele frequency: 2.339181286549708e-4
allele num: 8550
num of homozygotes: 0

African
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allele count: 5
allele frequency: 4.996003197442046e-4
allele num: 10008
num of homozygotes: 0

ClippingRankSum
type: SiteQuality
SIO_000300: -2.3e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: 1.0e-3

MQRankSum
type: SiteQuality
SIO_000300: 5.13e-1

FS
type: SiteQuality
SIO_000300: 1.235e0

MQ
type: SiteQuality
SIO_000300: 6.0e1

VQSLOD
type: SiteQuality
SIO_000300: 3.12e0

ReadPosRankSum
type: SiteQuality
SIO_000300: 5.87e-1

DP
type: SiteQuality
SIO_000300: 1.432436e6

QD
type: SiteQuality
SIO_000300: 1.367e1

BaseQRankSum
type: SiteQuality
SIO_000300: 3.62e-1

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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South Asian
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allele count: 0
allele frequency: 0.0e0
allele num: 16468
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11572
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 902
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8644
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6608
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10388
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 2
allele frequency: 3.008695128922586e-5
allele num: 66474
num of homozygotes: 0

InbreedingCoeff
type: SiteQuality
SIO_000300: 6.3e-3

VQSLOD
type: SiteQuality
SIO_000300: 1.93e0

QD
type: SiteQuality
SIO_000300: 1.429e1

DP
type: SiteQuality
SIO_000300: 1.676136e6

MQRankSum
type: SiteQuality
SIO_000300: -9.350000000000001e-1

BaseQRankSum
type: SiteQuality
SIO_000300: 8.26e-1

ReadPosRankSum
type: SiteQuality
SIO_000300: 9.5e-1

MQ
type: SiteQuality
SIO_000300: 5.532e1

FS
type: SiteQuality
SIO_000300: 6.26e-1

ClippingRankSum
type: SiteQuality
SIO_000300: -5.38e-1

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 1

African
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allele count: 0
allele frequency: 0.0e0
allele num: 10388
num of homozygotes: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
allele num: 8644
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16468
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 902
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11572
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.504347564461293e-5
allele num: 66474
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6608
num of homozygotes: 0

BaseQRankSum
type: SiteQuality
SIO_000300: 8.26e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: 6.3e-3

MQRankSum
type: SiteQuality
SIO_000300: -9.350000000000001e-1

VQSLOD
type: SiteQuality
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DP
type: SiteQuality
SIO_000300: 1.676136e6

MQ
type: SiteQuality
SIO_000300: 5.532e1

ClippingRankSum
type: SiteQuality
SIO_000300: -5.38e-1

QD
type: SiteQuality
SIO_000300: 1.429e1

ReadPosRankSum
type: SiteQuality
SIO_000300: 9.5e-1

FS
type: SiteQuality
SIO_000300: 6.26e-1

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6606
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 902
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10382
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66464
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16482
num of homozygotes: 0

Latino
type: Population
allele count: 1
allele frequency: 8.641548565502938e-5
allele num: 11572
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

MQRankSum
type: SiteQuality
SIO_000300: -1.178e0

ClippingRankSum
type: SiteQuality
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FS
type: SiteQuality
SIO_000300: 0.0e0

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.95e0

QD
type: SiteQuality
SIO_000300: 1.222e1

InbreedingCoeff
type: SiteQuality
SIO_000300: 1.02e-2

MQ
type: SiteQuality
SIO_000300: 5.977e1

DP
type: SiteQuality
SIO_000300: 1.678863e6

VQSLOD
type: SiteQuality
SIO_000300: -1.611e-1

BaseQRankSum
type: SiteQuality
SIO_000300: -3.582e0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 9.75e1
variant carriers: 1

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8646
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6604
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11572
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16488
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 900
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10384
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.504573904670197e-5
allele num: 66464
num of homozygotes: 0

MQRankSum
type: SiteQuality
SIO_000300: -1.802e0

DP
type: SiteQuality
SIO_000300: 1.681208e6

MQ
type: SiteQuality
SIO_000300: 5.846e1

BaseQRankSum
type: SiteQuality
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ClippingRankSum
type: SiteQuality
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FS
type: SiteQuality
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VQSLOD
type: SiteQuality
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ReadPosRankSum
type: SiteQuality
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InbreedingCoeff
type: SiteQuality
SIO_000300: -2.0e-4

QD
type: SiteQuality
SIO_000300: 9.949999999999999e0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 8.25e1
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African
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allele count: 0
allele frequency: 0.0e0
allele num: 10386
num of homozygotes: 0

South Asian
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allele count: 0
allele frequency: 0.0e0
allele num: 16478
num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 6606
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66462
num of homozygotes: 0

Latino
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allele count: 1
allele frequency: 8.641548565502938e-5
allele num: 11572
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
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Other
type: Population
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allele frequency: 0.0e0
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MQ
type: SiteQuality
SIO_000300: 6.0e1

ClippingRankSum
type: SiteQuality
SIO_000300: 2.87e-1

ReadPosRankSum
type: SiteQuality
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QD
type: SiteQuality
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VQSLOD
type: SiteQuality
SIO_000300: 7.53e-1

FS
type: SiteQuality
SIO_000300: 1.93e0

InbreedingCoeff
type: SiteQuality
SIO_000300: -2.0e-4

DP
type: SiteQuality
SIO_000300: 1.681506e6

MQRankSum
type: SiteQuality
SIO_000300: -4.48e-1

BaseQRankSum
type: SiteQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 7.75e1
variant carriers: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6606
num of homozygotes: 0

Other
type: Population
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East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8646
num of homozygotes: 0

European (Non-Finnish)
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allele count: 2
allele frequency: 3.009238361770636e-5
allele num: 66462
num of homozygotes: 0

African
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South Asian
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allele frequency: 0.0e0
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num of homozygotes: 0

Latino
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allele frequency: 0.0e0
allele num: 11570
num of homozygotes: 0

VQSLOD
type: SiteQuality
SIO_000300: 2.39e0

FS
type: SiteQuality
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MQRankSum
type: SiteQuality
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MQ
type: SiteQuality
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DP
type: SiteQuality
SIO_000300: 1.681594e6

BaseQRankSum
type: SiteQuality
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ReadPosRankSum
type: SiteQuality
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QD
type: SiteQuality
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ClippingRankSum
type: SiteQuality
SIO_000300: -4.51e-1

InbreedingCoeff
type: SiteQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 1

South Asian
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European (Non-Finnish)
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allele count: 0
allele frequency: 0.0e0
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East Asian
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allele num: 8646
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African
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allele frequency: 0.0e0
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Latino
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allele frequency: 0.0e0
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num of homozygotes: 0

European (Finnish)
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allele frequency: 0.0e0
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Other
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allele frequency: 0.0e0
allele num: 904
num of homozygotes: 0

VQSLOD
type: SiteQuality
SIO_000300: -5.723e-1

InbreedingCoeff
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MQRankSum
type: SiteQuality
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BaseQRankSum
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DP
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MQ
type: SiteQuality
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FS
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SIO_000300: 1.041e0

ReadPosRankSum
type: SiteQuality
SIO_000300: 9.6e-1

ClippingRankSum
type: SiteQuality
SIO_000300: -1.26e0

QD
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SIO_000300: 6.87e0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 2.25e1
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 8.75e1
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GenotypeQuality
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bin: 8.25e1
variant carriers: 0

South Asian
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allele count: 0
allele frequency: 0.0e0
allele num: 16502
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 904
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 2
allele frequency: 3.008514094888535e-5
allele num: 66478
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11568
num of homozygotes: 0

African
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allele count: 0
allele frequency: 0.0e0
allele num: 10382
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8646
num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 6604
num of homozygotes: 0

ReadPosRankSum
type: SiteQuality
SIO_000300: 2.03e-1

FS
type: SiteQuality
SIO_000300: 2.689e0

ClippingRankSum
type: SiteQuality
SIO_000300: 6.65e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: -1.0e-4

MQ
type: SiteQuality
SIO_000300: 5.944e1

BaseQRankSum
type: SiteQuality
SIO_000300: -1.96e-1

QD
type: SiteQuality
SIO_000300: 1.509e1

VQSLOD
type: SiteQuality
SIO_000300: 6.6e-1

MQRankSum
type: SiteQuality
SIO_000300: 8.599999999999999e-2

DP
type: SiteQuality
SIO_000300: 1.684503e6

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

South Asian
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allele count: 0
allele frequency: 0.0e0
allele num: 16502
num of homozygotes: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
allele num: 8646
num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 6606
num of homozygotes: 0

African
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allele count: 1
allele frequency: 9.632055480639569e-5
allele num: 10382
num of homozygotes: 0

Latino
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allele count: 0
allele frequency: 0.0e0
allele num: 11570
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66480
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 904
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BaseQRankSum
type: SiteQuality
SIO_000300: 2.09e0

ReadPosRankSum
type: SiteQuality
SIO_000300: 2.78e0

InbreedingCoeff
type: SiteQuality
SIO_000300: -1.0e-4

DP
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SIO_000300: 1.68455e6

FS
type: SiteQuality
SIO_000300: 2.874e0

MQRankSum
type: SiteQuality
SIO_000300: 1.2e0

QD
type: SiteQuality
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ClippingRankSum
type: SiteQuality
SIO_000300: -1.704e0

VQSLOD
type: SiteQuality
SIO_000300: 1.51e-1

MQ
type: SiteQuality
SIO_000300: 5.964e1

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

South Asian
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allele count: 0
allele frequency: 0.0e0
allele num: 16506
num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 6606
num of homozygotes: 0

East Asian
type: Population
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allele frequency: 0.0e0
allele num: 8644
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 906
num of homozygotes: 0

Latino
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allele count: 0
allele frequency: 0.0e0
allele num: 11572
num of homozygotes: 0

European (Non-Finnish)
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allele count: 1
allele frequency: 1.50407604608489e-5
allele num: 66486
num of homozygotes: 0

African
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allele count: 0
allele frequency: 0.0e0
allele num: 10384
num of homozygotes: 0

MQ
type: SiteQuality
SIO_000300: 5.965e1

InbreedingCoeff
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SIO_000300: -1.0e-4

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.99e0

FS
type: SiteQuality
SIO_000300: 1.239e0

MQRankSum
type: SiteQuality
SIO_000300: 7.73e-1

BaseQRankSum
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SIO_000300: -1.813e0

ClippingRankSum
type: SiteQuality
SIO_000300: 8.69e-1

VQSLOD
type: SiteQuality
SIO_000300: -3.283e0

DP
type: SiteQuality
SIO_000300: 1.684735e6

QD
type: SiteQuality
SIO_000300: 2.622e1

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 6606
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8644
num of homozygotes: 0

European (Non-Finnish)
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allele count: 1
allele frequency: 1.504211793020457e-5
allele num: 66480
num of homozygotes: 0

Latino
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allele count: 0
allele frequency: 0.0e0
allele num: 11572
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16506
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10384
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 906
num of homozygotes: 0

QD
type: SiteQuality
SIO_000300: 1.573e1

ClippingRankSum
type: SiteQuality
SIO_000300: -8.999999999999999e-3

MQRankSum
type: SiteQuality
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DP
type: SiteQuality
SIO_000300: 1.684939e6

BaseQRankSum
type: SiteQuality
SIO_000300: 4.04e0

FS
type: SiteQuality
SIO_000300: 1.247e0

VQSLOD
type: SiteQuality
SIO_000300: 1.44e0

MQ
type: SiteQuality
SIO_000300: 5.951e1

InbreedingCoeff
type: SiteQuality
SIO_000300: -1.0e-4

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.73e-1

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 2

Latino
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allele count: 0
allele frequency: 0.0e0
allele num: 11568
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10382
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16508
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 904
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.503714174009804e-5
allele num: 66502
num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 6604
num of homozygotes: 0

East Asian
type: Population
allele count: 1
allele frequency: 1.156871818602499e-4
allele num: 8644
num of homozygotes: 0

ReadPosRankSum
type: SiteQuality
SIO_000300: -1.309e0

BaseQRankSum
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FS
type: SiteQuality
SIO_000300: 1.431e0

DP
type: SiteQuality
SIO_000300: 1.685461e6

ClippingRankSum
type: SiteQuality
SIO_000300: -9.79e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: 2.2e-3

VQSLOD
type: SiteQuality
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MQRankSum
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SIO_000300: -1.015e0

MQ
type: SiteQuality
SIO_000300: 5.843e1

QD
type: SiteQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

South Asian
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allele frequency: 3.028834504482675e-4
allele num: 16508
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6604
num of homozygotes: 0

African
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allele count: 191
allele frequency: 1.839368258859784e-2
allele num: 10384
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8644
num of homozygotes: 0

Latino
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allele count: 10
allele frequency: 8.644536652835408e-4
allele num: 11568
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 2
allele frequency: 3.007699711260828e-5
allele num: 66496
num of homozygotes: 0

Other
type: Population
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allele frequency: 0.0e0
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num of homozygotes: 0

ReadPosRankSum
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MQ
type: SiteQuality
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InbreedingCoeff
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BaseQRankSum
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MQRankSum
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VQSLOD
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ClippingRankSum
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DP
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FS
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QD
type: SiteQuality
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GenotypeQuality
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bin: 4.75e1
variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 3.25e1
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GenotypeQuality
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bin: 8.75e1
variant carriers: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 6604
num of homozygotes: 0

European (Non-Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 66500
num of homozygotes: 0

East Asian
type: Population
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allele frequency: 1.156871818602499e-4
allele num: 8644
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11568
num of homozygotes: 0

South Asian
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allele frequency: 0.0e0
allele num: 16508
num of homozygotes: 0

Other
type: Population
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allele frequency: 0.0e0
allele num: 904
num of homozygotes: 0

African
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allele count: 0
allele frequency: 0.0e0
allele num: 10380
num of homozygotes: 0

MQ
type: SiteQuality
SIO_000300: 6.0e1

InbreedingCoeff
type: SiteQuality
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QD
type: SiteQuality
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FS
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VQSLOD
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MQRankSum
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BaseQRankSum
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DP
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SIO_000300: 1.676148e6

ReadPosRankSum
type: SiteQuality
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ClippingRankSum
type: SiteQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 7.25e1
variant carriers: 0

Other
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allele num: 904
num of homozygotes: 0

South Asian
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

African
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allele count: 0
allele frequency: 0.0e0
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European (Finnish)
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allele count: 0
allele frequency: 0.0e0
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European (Non-Finnish)
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allele count: 1
allele frequency: 1.503714174009804e-5
allele num: 66502
num of homozygotes: 0

East Asian
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allele frequency: 1.156871818602499e-4
allele num: 8644
num of homozygotes: 0

Latino
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allele frequency: 0.0e0
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num of homozygotes: 0

QD
type: SiteQuality
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FS
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BaseQRankSum
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ReadPosRankSum
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ClippingRankSum
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MQRankSum
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InbreedingCoeff
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MQ
type: SiteQuality
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VQSLOD
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DP
type: SiteQuality
SIO_000300: 1.676362e6

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 2.75e1
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GenotypeQuality
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bin: 6.25e1
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GenotypeQuality
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bin: 9.75e1
variant carriers: 4

Other
type: Population
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allele frequency: 0.0e0
allele num: 904
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

African
type: Population
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allele frequency: 0.0e0
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num of homozygotes: 0

Latino
type: Population
allele count: 1
allele frequency: 8.644536652835408e-5
allele num: 11568
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6602
num of homozygotes: 0

South Asian
type: Population
allele count: 3
allele frequency: 1.817300702689605e-4
allele num: 16508
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8644
num of homozygotes: 0

BaseQRankSum
type: SiteQuality
SIO_000300: 2.12e0

MQRankSum
type: SiteQuality
SIO_000300: 2.12e-1

FS
type: SiteQuality
SIO_000300: 1.763e0

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.7e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: 2.4e-3

ClippingRankSum
type: SiteQuality
SIO_000300: 5.600000000000001e-1

MQ
type: SiteQuality
SIO_000300: 5.977e1

VQSLOD
type: SiteQuality
SIO_000300: 2.91e0

DP
type: SiteQuality
SIO_000300: 1.676221e6

QD
type: SiteQuality
SIO_000300: 1.416e1

GenotypeQuality
all individuals: 6
bin: 1.25e1
variant carriers: 0

GenotypeQuality
all individuals: 13
bin: 7.5e0
variant carriers: 0

GenotypeQuality
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bin: 9.75e1
variant carriers: 1

GenotypeQuality
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bin: 3.25e1
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GenotypeQuality
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bin: 7.75e1
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GenotypeQuality
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bin: 6.75e1
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GenotypeQuality
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bin: 1.75e1
variant carriers: 0

GenotypeQuality
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bin: 5.75e1
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GenotypeQuality
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bin: 8.75e1
variant carriers: 0

GenotypeQuality
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bin: 2.25e1
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GenotypeQuality
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bin: 3.75e1
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GenotypeQuality
all individuals: 2029
bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 8
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 27
bin: 2.75e1
variant carriers: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10384
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11568
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66498
num of homozygotes: 0

East Asian
type: Population
allele count: 1
allele frequency: 1.156871818602499e-4
allele num: 8644
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6602
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16508
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 904
num of homozygotes: 0

VQSLOD
type: SiteQuality
SIO_000300: 9.370000000000001e-1

BaseQRankSum
type: SiteQuality
SIO_000300: -5.58e0

DP
type: SiteQuality
SIO_000300: 1.675868e6

ReadPosRankSum
type: SiteQuality
SIO_000300: -2.1e-1

MQRankSum
type: SiteQuality
SIO_000300: 3.39e-1

ClippingRankSum
type: SiteQuality
SIO_000300: -8.500000000000001e-2

FS
type: SiteQuality
SIO_000300: 1.384e0

MQ
type: SiteQuality
SIO_000300: 5.982e1

QD
type: SiteQuality
SIO_000300: 1.164e1

InbreedingCoeff
type: SiteQuality
SIO_000300: 3.1e-3

GenotypeQuality
all individuals: 45423
bin: 6.25e1
variant carriers: 0

GenotypeQuality
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bin: 4.75e1
variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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bin: 2.5e0
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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bin: 9.25e1
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GenotypeQuality
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bin: 2.75e1
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
all individuals: 1851
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variant carriers: 0

GenotypeQuality
all individuals: 178
bin: 2.25e1
variant carriers: 0

African
type: Population
allele count: 17
allele frequency: 1.6368187945311e-3
allele num: 10386
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 904
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11568
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8644
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6602
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66486
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16508
num of homozygotes: 0

MQRankSum
type: SiteQuality
SIO_000300: 4.16e-1

DP
type: SiteQuality
SIO_000300: 1.676517e6

ReadPosRankSum
type: SiteQuality
SIO_000300: 4.2e-1

QD
type: SiteQuality
SIO_000300: 1.355e1

BaseQRankSum
type: SiteQuality
SIO_000300: 9.6e-1

ClippingRankSum
type: SiteQuality
SIO_000300: -1.32e-1

FS
type: SiteQuality
SIO_000300: 0.0e0

InbreedingCoeff
type: SiteQuality
SIO_000300: 1.3e-3

MQ
type: SiteQuality
SIO_000300: 5.951e1

VQSLOD
type: SiteQuality
SIO_000300: 5.13e0

GenotypeQuality
all individuals: 203
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 210
bin: 8.75e1
variant carriers: 0

GenotypeQuality
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bin: 7.5e0
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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bin: 1.75e1
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 2

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
all individuals: 12
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 9351
bin: 6.75e1
variant carriers: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6602
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8644
num of homozygotes: 0

Latino
type: Population
allele count: 1
allele frequency: 8.644536652835408e-5
allele num: 11568
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10388
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 904
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66482
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.05766900896535e-5
allele num: 16508
num of homozygotes: 0

QD
type: SiteQuality
SIO_000300: 1.325e1

ClippingRankSum
type: SiteQuality
SIO_000300: -7.61e-1

FS
type: SiteQuality
SIO_000300: 1.0457e1

BaseQRankSum
type: SiteQuality
SIO_000300: 1.1e0

DP
type: SiteQuality
SIO_000300: 1.675057e6

MQRankSum
type: SiteQuality
SIO_000300: 9.49e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: 0.0e0

VQSLOD
type: SiteQuality
SIO_000300: -7.432e-1

MQ
type: SiteQuality
SIO_000300: 5.98e1

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.32e0

GenotypeQuality
all individuals: 2
bin: 2.5e0
variant carriers: 0

GenotypeQuality
all individuals: 5
bin: 1.25e1
variant carriers: 0

GenotypeQuality
all individuals: 13
bin: 4.75e1
variant carriers: 0

GenotypeQuality
all individuals: 13
bin: 5.25e1
variant carriers: 0

GenotypeQuality
all individuals: 13
bin: 7.5e0
variant carriers: 0

GenotypeQuality
all individuals: 208
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GenotypeQuality
all individuals: 14
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GenotypeQuality
all individuals: 15
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variant carriers: 0

GenotypeQuality
all individuals: 1848
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variant carriers: 0

GenotypeQuality
all individuals: 8
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GenotypeQuality
all individuals: 2029
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GenotypeQuality
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bin: 9.75e1
variant carriers: 1

GenotypeQuality
all individuals: 203
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 45440
bin: 6.25e1
variant carriers: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10386
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16508
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66476
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11568
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8644
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 904
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 1
allele frequency: 1.515151515151515e-4
allele num: 6600
num of homozygotes: 0

MQRankSum
type: SiteQuality
SIO_000300: -4.95e-1

VQSLOD
type: SiteQuality
SIO_000300: 7.16e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: 1.0e-4

MQ
type: SiteQuality
SIO_000300: 6.0e1

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.35e0

QD
type: SiteQuality
SIO_000300: 1.266e1

DP
type: SiteQuality
SIO_000300: 1.674782e6

BaseQRankSum
type: SiteQuality
SIO_000300: -5.548e0

FS
type: SiteQuality
SIO_000300: 0.0e0

ClippingRankSum
type: SiteQuality
SIO_000300: -1.436e0

GenotypeQuality
all individuals: 198
bin: 2.25e1
variant carriers: 0

GenotypeQuality
all individuals: 15
bin: 4.75e1
variant carriers: 0

GenotypeQuality
all individuals: 6
bin: 4.25e1
variant carriers: 0

GenotypeQuality
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bin: 6.25e1
variant carriers: 0

GenotypeQuality
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GenotypeQuality
all individuals: 15
bin: 7.5e0
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GenotypeQuality
all individuals: 4
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GenotypeQuality
all individuals: 28
bin: 3.25e1
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GenotypeQuality
all individuals: 208
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 6.75e1
variant carriers: 0

GenotypeQuality
all individuals: 203
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 14
bin: 3.75e1
variant carriers: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10386
num of homozygotes: 0

East Asian
type: Population
allele count: 5
allele frequency: 5.784359093012494e-4
allele num: 8644
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.504347564461293e-5
allele num: 66474
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6602
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16508
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 904
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11568
num of homozygotes: 0

FS
type: SiteQuality
SIO_000300: 2.432e0

MQRankSum
type: SiteQuality
SIO_000300: 9.0e-2

DP
type: SiteQuality
SIO_000300: 1.675279e6

VQSLOD
type: SiteQuality
SIO_000300: 1.86e0

QD
type: SiteQuality
SIO_000300: 1.253e1

MQ
type: SiteQuality
SIO_000300: 5.952e1

InbreedingCoeff
type: SiteQuality
SIO_000300: 1.0e-4

BaseQRankSum
type: SiteQuality
SIO_000300: 1.78e0

ReadPosRankSum
type: SiteQuality
SIO_000300: -1.48e-1

ClippingRankSum
type: SiteQuality
SIO_000300: 3.53e-1

GenotypeQuality
all individuals: 4
bin: 2.5e0
variant carriers: 0

GenotypeQuality
all individuals: 9
bin: 1.75e1
variant carriers: 0

GenotypeQuality
all individuals: 14
bin: 3.75e1
variant carriers: 0

GenotypeQuality
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GenotypeQuality
all individuals: 15
bin: 4.75e1
variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
all individuals: 28
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variant carriers: 0

GenotypeQuality
all individuals: 6
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variant carriers: 0

GenotypeQuality
all individuals: 585
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variant carriers: 14

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10386
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 904
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8644
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11568
num of homozygotes: 0

South Asian
type: Population
allele count: 13
allele frequency: 7.874969711654955e-4
allele num: 16508
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6602
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.504347564461293e-5
allele num: 66474
num of homozygotes: 0

VQSLOD
type: SiteQuality
SIO_000300: 1.86e0

BaseQRankSum
type: SiteQuality
SIO_000300: 1.78e0

ClippingRankSum
type: SiteQuality
SIO_000300: 3.53e-1

QD
type: SiteQuality
SIO_000300: 1.253e1

InbreedingCoeff
type: SiteQuality
SIO_000300: 1.0e-4

FS
type: SiteQuality
SIO_000300: 2.432e0

ReadPosRankSum
type: SiteQuality
SIO_000300: -1.48e-1

MQ
type: SiteQuality
SIO_000300: 5.952e1

MQRankSum
type: SiteQuality
SIO_000300: 9.0e-2

DP
type: SiteQuality
SIO_000300: 1.675279e6

GenotypeQuality
all individuals: 32
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 8
bin: 1.75e1
variant carriers: 0

GenotypeQuality
all individuals: 7
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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variant carriers: 1

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 6.75e1
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GenotypeQuality
all individuals: 11
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GenotypeQuality
all individuals: 208
bin: 2.25e1
variant carriers: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16508
num of homozygotes: 0

African
type: Population
allele count: 1
allele frequency: 9.63020030816641e-5
allele num: 10384
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8644
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11568
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 904
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66460
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6602
num of homozygotes: 0

ReadPosRankSum
type: SiteQuality
SIO_000300: 7.58e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: -1.0e-4

VQSLOD
type: SiteQuality
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MQ
type: SiteQuality
SIO_000300: 6.0e1

DP
type: SiteQuality
SIO_000300: 1.673899e6

FS
type: SiteQuality
SIO_000300: 1.351e0

ClippingRankSum
type: SiteQuality
SIO_000300: -5.49e-1

MQRankSum
type: SiteQuality
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QD
type: SiteQuality
SIO_000300: 1.622e1

BaseQRankSum
type: SiteQuality
SIO_000300: 1.65e0

GenotypeQuality
all individuals: 8
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
all individuals: 699
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GenotypeQuality
all individuals: 567
bin: 9.75e1
variant carriers: 3

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8644
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10386
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 904
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6604
num of homozygotes: 0

South Asian
type: Population
allele count: 3
allele frequency: 1.817300702689605e-4
allele num: 16508
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11568
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66462
num of homozygotes: 0

VQSLOD
type: SiteQuality
SIO_000300: 8.169999999999999e-1

ClippingRankSum
type: SiteQuality
SIO_000300: 3.87e-1

MQRankSum
type: SiteQuality
SIO_000300: 7.9e-2

FS
type: SiteQuality
SIO_000300: 1.651e0

MQ
type: SiteQuality
SIO_000300: 5.982e1

InbreedingCoeff
type: SiteQuality
SIO_000300: -1.0e-4

QD
type: SiteQuality
SIO_000300: 1.12e1

DP
type: SiteQuality
SIO_000300: 1.673963e6

BaseQRankSum
type: SiteQuality
SIO_000300: -1.28e0

ReadPosRankSum
type: SiteQuality
SIO_000300: -6.05e-1

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
all individuals: 4
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 14
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variant carriers: 0

GenotypeQuality
all individuals: 10
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GenotypeQuality
all individuals: 699
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GenotypeQuality
all individuals: 9354
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variant carriers: 0

GenotypeQuality
all individuals: 19
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GenotypeQuality
all individuals: 206
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variant carriers: 0

GenotypeQuality
all individuals: 206
bin: 2.25e1
variant carriers: 0

GenotypeQuality
all individuals: 563
bin: 9.75e1
variant carriers: 2

GenotypeQuality
all individuals: 45464
bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 203
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1847
bin: 7.75e1
variant carriers: 0

European (Non-Finnish)
type: Population
allele count: 2
allele frequency: 3.00960062599693e-5
allele num: 66454
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6604
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8644
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11568
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10384
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16508
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 904
num of homozygotes: 0

ClippingRankSum
type: SiteQuality
SIO_000300: 3.77e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: -1.0e-4

BaseQRankSum
type: SiteQuality
SIO_000300: 5.3e0

VQSLOD
type: SiteQuality
SIO_000300: 1.2e0

DP
type: SiteQuality
SIO_000300: 1.673687e6

QD
type: SiteQuality
SIO_000300: 1.322e1

FS
type: SiteQuality
SIO_000300: 4.087e0

MQRankSum
type: SiteQuality
SIO_000300: 5.6e-2

ReadPosRankSum
type: SiteQuality
SIO_000300: 9.45e-1

MQ
type: SiteQuality
SIO_000300: 5.983e1

GenotypeQuality
all individuals: 4
bin: 1.25e1
variant carriers: 0

GenotypeQuality
all individuals: 10
bin: 1.75e1
variant carriers: 0

GenotypeQuality
all individuals: 13
bin: 5.25e1
variant carriers: 0

GenotypeQuality
all individuals: 0
bin: 2.5e0
variant carriers: 0

GenotypeQuality
all individuals: 12
bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 8
bin: 4.75e1
variant carriers: 0

GenotypeQuality
all individuals: 26
bin: 3.25e1
variant carriers: 0

GenotypeQuality
all individuals: 204
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 224
bin: 2.25e1
variant carriers: 0

GenotypeQuality
all individuals: 45447
bin: 6.25e1
variant carriers: 0

GenotypeQuality
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bin: 9.75e1
variant carriers: 68

GenotypeQuality
all individuals: 1840
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variant carriers: 0

GenotypeQuality
all individuals: 7
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 698
bin: 8.25e1
variant carriers: 0

European (Non-Finnish)
type: Population
allele count: 3
allele frequency: 4.515760002408406e-5
allele num: 66434
num of homozygotes: 0

African
type: Population
allele count: 59
allele frequency: 5.685103102717286e-3
allele num: 10378
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 904
num of homozygotes: 0

Latino
type: Population
allele count: 6
allele frequency: 5.188516084399862e-4
allele num: 11564
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8646
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16508
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6598
num of homozygotes: 0

InbreedingCoeff
type: SiteQuality
SIO_000300: -7.0e-4

ReadPosRankSum
type: SiteQuality
SIO_000300: 5.33e-1

FS
type: SiteQuality
SIO_000300: 0.0e0

MQRankSum
type: SiteQuality
SIO_000300: 3.73e-1

VQSLOD
type: SiteQuality
SIO_000300: 5.85e0

ClippingRankSum
type: SiteQuality
SIO_000300: -2.87e-1

QD
type: SiteQuality
SIO_000300: 1.237e1

DP
type: SiteQuality
SIO_000300: 1.675432e6

BaseQRankSum
type: SiteQuality
SIO_000300: -3.277e0

MQ
type: SiteQuality
SIO_000300: 5.962e1

GenotypeQuality
all individuals: 9355
bin: 6.75e1
variant carriers: 0

GenotypeQuality
all individuals: 12
bin: 1.75e1
variant carriers: 0

GenotypeQuality
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bin: 8.75e1
variant carriers: 0

GenotypeQuality
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bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 25
bin: 7.5e0
variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
all individuals: 7
bin: 4.75e1
variant carriers: 0

GenotypeQuality
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bin: 5.25e1
variant carriers: 0

GenotypeQuality
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bin: 7.75e1
variant carriers: 0

GenotypeQuality
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bin: 9.25e1
variant carriers: 0

GenotypeQuality
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bin: 5.75e1
variant carriers: 0

GenotypeQuality
all individuals: 503
bin: 9.75e1
variant carriers: 2

GenotypeQuality
all individuals: 3
bin: 1.25e1
variant carriers: 0

GenotypeQuality
all individuals: 2023
bin: 7.25e1
variant carriers: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 904
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66424
num of homozygotes: 0

East Asian
type: Population
allele count: 2
allele frequency: 2.313208420078649e-4
allele num: 8646
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6598
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11564
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10380
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16508
num of homozygotes: 0

ReadPosRankSum
type: SiteQuality
SIO_000300: 3.03e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: -2.0e-4

BaseQRankSum
type: SiteQuality
SIO_000300: -1.746e0

QD
type: SiteQuality
SIO_000300: 7.23e0

MQRankSum
type: SiteQuality
SIO_000300: 3.0e-3

FS
type: SiteQuality
SIO_000300: 7.822e0

ClippingRankSum
type: SiteQuality
SIO_000300: -8.0e-3

DP
type: SiteQuality
SIO_000300: 1.670281e6

VQSLOD
type: SiteQuality
SIO_000300: -1.323e0

MQ
type: SiteQuality
SIO_000300: 5.917e1

GenotypeQuality
all individuals: 205
bin: 8.75e1
variant carriers: 0

GenotypeQuality
all individuals: 34
bin: 3.25e1
variant carriers: 0

GenotypeQuality
all individuals: 17
bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 28
bin: 5.75e1
variant carriers: 0

GenotypeQuality
all individuals: 1837
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 9336
bin: 6.75e1
variant carriers: 0

GenotypeQuality
all individuals: 3
bin: 2.5e0
variant carriers: 0

GenotypeQuality
all individuals: 203
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 42
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 497
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variant carriers: 4

GenotypeQuality
all individuals: 18
bin: 4.75e1
variant carriers: 0

GenotypeQuality
all individuals: 9
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 36
bin: 7.5e0
variant carriers: 0

GenotypeQuality
all individuals: 45360
bin: 6.25e1
variant carriers: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8646
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6588
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16508
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10356
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 904
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11558
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 4
allele frequency: 6.029362997799283e-5
allele num: 66342
num of homozygotes: 0

MQRankSum
type: SiteQuality
SIO_000300: 1.07e0

InbreedingCoeff
type: SiteQuality
SIO_000300: 2.9e-3

VQSLOD
type: SiteQuality
SIO_000300: 9.15e-1

ReadPosRankSum
type: SiteQuality
SIO_000300: 4.98e-1

FS
type: SiteQuality
SIO_000300: 3.604e0

DP
type: SiteQuality
SIO_000300: 1.668364e6

MQ
type: SiteQuality
SIO_000300: 5.976e1

ClippingRankSum
type: SiteQuality
SIO_000300: 8.7e-1

BaseQRankSum
type: SiteQuality
SIO_000300: -2.726e0

QD
type: SiteQuality
SIO_000300: 1.174e1

GenotypeQuality
all individuals: 2018
bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 492
bin: 9.75e1
variant carriers: 1

GenotypeQuality
all individuals: 12
bin: 1.75e1
variant carriers: 0

GenotypeQuality
all individuals: 203
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 7
bin: 2.5e0
variant carriers: 0

GenotypeQuality
all individuals: 9
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variant carriers: 0

GenotypeQuality
all individuals: 203
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variant carriers: 0

GenotypeQuality
all individuals: 11
bin: 1.25e1
variant carriers: 0

GenotypeQuality
all individuals: 32
bin: 7.5e0
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GenotypeQuality
all individuals: 34
bin: 3.25e1
variant carriers: 0

GenotypeQuality
all individuals: 691
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variant carriers: 0

GenotypeQuality
all individuals: 1837
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 45408
bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 9
bin: 4.25e1
variant carriers: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66330
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 904
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16508
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11558
num of homozygotes: 0

East Asian
type: Population
allele count: 1
allele frequency: 1.156604210039325e-4
allele num: 8646
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6588
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10354
num of homozygotes: 0

ClippingRankSum
type: SiteQuality
SIO_000300: -5.74e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: 3.1e-3

ReadPosRankSum
type: SiteQuality
SIO_000300: 4.97e-1

DP
type: SiteQuality
SIO_000300: 1.667888e6

FS
type: SiteQuality
SIO_000300: 4.204e0

QD
type: SiteQuality
SIO_000300: 1.155e1

MQ
type: SiteQuality
SIO_000300: 5.911e1

VQSLOD
type: SiteQuality
SIO_000300: 1.1e-1

BaseQRankSum
type: SiteQuality
SIO_000300: 3.79e0

MQRankSum
type: SiteQuality
SIO_000300: -4.05e-1

GenotypeQuality
all individuals: 39
bin: 7.5e0
variant carriers: 0

GenotypeQuality
all individuals: 19
bin: 4.75e1
variant carriers: 0

GenotypeQuality
all individuals: 7
bin: 2.5e0
variant carriers: 0

GenotypeQuality
all individuals: 22
bin: 5.75e1
variant carriers: 0

GenotypeQuality
all individuals: 203
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 45397
bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 17
bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 31
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variant carriers: 0

GenotypeQuality
all individuals: 687
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variant carriers: 0

GenotypeQuality
all individuals: 9324
bin: 6.75e1
variant carriers: 0

GenotypeQuality
all individuals: 201
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variant carriers: 0

GenotypeQuality
all individuals: 13
bin: 1.75e1
variant carriers: 0

GenotypeQuality
all individuals: 45
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 11
bin: 4.25e1
variant carriers: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10356
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8642
num of homozygotes: 0

Latino
type: Population
allele count: 1
allele frequency: 8.652015919709292e-5
allele num: 11558
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6588
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.05766900896535e-5
allele num: 16508
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 5
allele frequency: 7.540795704762766e-5
allele num: 66306
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 902
num of homozygotes: 0

DP
type: SiteQuality
SIO_000300: 1.667487e6

QD
type: SiteQuality
SIO_000300: 1.179e1

ReadPosRankSum
type: SiteQuality
SIO_000300: 7.74e-1

BaseQRankSum
type: SiteQuality
SIO_000300: 1.98e0

MQRankSum
type: SiteQuality
SIO_000300: -2.42e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: 1.9e-3

FS
type: SiteQuality
SIO_000300: 2.684e0

ClippingRankSum
type: SiteQuality
SIO_000300: -3.37e-1

MQ
type: SiteQuality
SIO_000300: 6.0e1

VQSLOD
type: SiteQuality
SIO_000300: 9.98e-1

GenotypeQuality
all individuals: 43
bin: 7.5e0
variant carriers: 0

GenotypeQuality
all individuals: 21
bin: 5.25e1
variant carriers: 0

GenotypeQuality
all individuals: 45406
bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 483
bin: 9.75e1
variant carriers: 3

GenotypeQuality
all individuals: 17
bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 328
bin: 2.25e1
variant carriers: 0

GenotypeQuality
all individuals: 31
bin: 3.25e1
variant carriers: 0

GenotypeQuality
all individuals: 10
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GenotypeQuality
all individuals: 11
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variant carriers: 0

GenotypeQuality
all individuals: 2012
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variant carriers: 0

GenotypeQuality
all individuals: 9322
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variant carriers: 0

GenotypeQuality
all individuals: 20
bin: 4.75e1
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GenotypeQuality
all individuals: 201
bin: 8.75e1
variant carriers: 0

GenotypeQuality
all individuals: 202
bin: 9.25e1
variant carriers: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16508
num of homozygotes: 0

African
type: Population
allele count: 1
allele frequency: 9.658103148541626e-5
allele num: 10354
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 2
allele frequency: 3.016682252858306e-5
allele num: 66298
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 902
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6588
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8642
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11558
num of homozygotes: 0

MQ
type: SiteQuality
SIO_000300: 5.961e1

QD
type: SiteQuality
SIO_000300: 1.322e1

BaseQRankSum
type: SiteQuality
SIO_000300: -4.92e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: -4.0e-4

FS
type: SiteQuality
SIO_000300: 2.589e0

VQSLOD
type: SiteQuality
SIO_000300: 2.46e0

DP
type: SiteQuality
SIO_000300: 1.666973e6

MQRankSum
type: SiteQuality
SIO_000300: 2.07e-1

ReadPosRankSum
type: SiteQuality
SIO_000300: 6.08e-1

ClippingRankSum
type: SiteQuality
SIO_000300: -9.52e-1

GenotypeQuality
all individuals: 26
bin: 5.25e1
variant carriers: 0

GenotypeQuality
all individuals: 485
bin: 9.75e1
variant carriers: 17

GenotypeQuality
all individuals: 45389
bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 17
bin: 4.75e1
variant carriers: 0

GenotypeQuality
all individuals: 1830
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GenotypeQuality
all individuals: 7
bin: 1.75e1
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GenotypeQuality
all individuals: 13
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GenotypeQuality
all individuals: 201
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GenotypeQuality
all individuals: 9316
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GenotypeQuality
all individuals: 44
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GenotypeQuality
all individuals: 200
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GenotypeQuality
all individuals: 49
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variant carriers: 0

GenotypeQuality
all individuals: 10
bin: 1.25e1
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GenotypeQuality
all individuals: 684
bin: 8.25e1
variant carriers: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 900
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66292
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10352
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11556
num of homozygotes: 0

South Asian
type: Population
allele count: 17
allele frequency: 1.029803731524109e-3
allele num: 16508
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6586
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8642
num of homozygotes: 0

FS
type: SiteQuality
SIO_000300: 6.278e0

InbreedingCoeff
type: SiteQuality
SIO_000300: -4.0e-4

ReadPosRankSum
type: SiteQuality
SIO_000300: 5.97e-1

MQRankSum
type: SiteQuality
SIO_000300: 2.66e-1

ClippingRankSum
type: SiteQuality
SIO_000300: -4.3e-2

DP
type: SiteQuality
SIO_000300: 1.66698e6

VQSLOD
type: SiteQuality
SIO_000300: 8.88e-1

QD
type: SiteQuality
SIO_000300: 1.355e1

BaseQRankSum
type: SiteQuality
SIO_000300: -1.506e0

MQ
type: SiteQuality
SIO_000300: 5.971e1

GenotypeQuality
all individuals: 52
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 10
bin: 1.75e1
variant carriers: 0

GenotypeQuality
all individuals: 372
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
all individuals: 20
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GenotypeQuality
all individuals: 34
bin: 3.25e1
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GenotypeQuality
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GenotypeQuality
all individuals: 9310
bin: 6.75e1
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GenotypeQuality
all individuals: 468
bin: 9.75e1
variant carriers: 2

GenotypeQuality
all individuals: 2013
bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 200
bin: 8.75e1
variant carriers: 0

GenotypeQuality
all individuals: 10
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1826
bin: 7.75e1
variant carriers: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10352
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8642
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.05766900896535e-5
allele num: 16508
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.508705229172324e-5
allele num: 66282
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11550
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6580
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 900
num of homozygotes: 0

FS
type: SiteQuality
SIO_000300: 1.882e0

InbreedingCoeff
type: SiteQuality
SIO_000300: -4.0e-4

BaseQRankSum
type: SiteQuality
SIO_000300: -6.5e-2

MQRankSum
type: SiteQuality
SIO_000300: 1.14e-1

VQSLOD
type: SiteQuality
SIO_000300: 1.32e0

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.03e0

ClippingRankSum
type: SiteQuality
SIO_000300: -9.47e-1

QD
type: SiteQuality
SIO_000300: 1.243e1

MQ
type: SiteQuality
SIO_000300: 5.963e1

DP
type: SiteQuality
SIO_000300: 1.665422e6

GenotypeQuality
all individuals: 42
bin: 7.5e0
variant carriers: 0

GenotypeQuality
all individuals: 45382
bin: 6.25e1
variant carriers: 0

GenotypeQuality
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bin: 5.75e1
variant carriers: 0

GenotypeQuality
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bin: 2.5e0
variant carriers: 0

GenotypeQuality
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bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 200
bin: 8.75e1
variant carriers: 0

GenotypeQuality
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bin: 9.75e1
variant carriers: 1

GenotypeQuality
all individuals: 15
bin: 4.75e1
variant carriers: 0

GenotypeQuality
all individuals: 9305
bin: 6.75e1
variant carriers: 0

GenotypeQuality
all individuals: 18
bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 390
bin: 2.25e1
variant carriers: 0

GenotypeQuality
all individuals: 199
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1826
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 2010
bin: 7.25e1
variant carriers: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10352
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 900
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.05766900896535e-5
allele num: 16508
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66286
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8642
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11550
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6578
num of homozygotes: 0

QD
type: SiteQuality
SIO_000300: 2.335e1

MQRankSum
type: SiteQuality
SIO_000300: 7.78e-1

ClippingRankSum
type: SiteQuality
SIO_000300: -1.37e0

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.18e0

InbreedingCoeff
type: SiteQuality
SIO_000300: -3.0e-4

DP
type: SiteQuality
SIO_000300: 1.665059e6

VQSLOD
type: SiteQuality
SIO_000300: -2.233e0

MQ
type: SiteQuality
SIO_000300: 5.89e1

BaseQRankSum
type: SiteQuality
SIO_000300: -8.98e-1

FS
type: SiteQuality
SIO_000300: 1.029e0

GenotypeQuality
all individuals: 1823
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 8
bin: 2.5e0
variant carriers: 0

GenotypeQuality
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bin: 6.75e1
variant carriers: 0

GenotypeQuality
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bin: 1.75e1
variant carriers: 0

GenotypeQuality
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bin: 3.25e1
variant carriers: 0

GenotypeQuality
all individuals: 10
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 21
bin: 4.75e1
variant carriers: 0

GenotypeQuality
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bin: 6.25e1
variant carriers: 0

GenotypeQuality
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bin: 5.75e1
variant carriers: 0

GenotypeQuality
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bin: 9.25e1
variant carriers: 0

GenotypeQuality
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bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 45
bin: 5.25e1
variant carriers: 0

GenotypeQuality
all individuals: 197
bin: 8.75e1
variant carriers: 0

GenotypeQuality
all individuals: 464
bin: 9.75e1
variant carriers: 1

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8638
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 898
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6550
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16506
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.510574018126888e-5
allele num: 66200
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10328
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11542
num of homozygotes: 0

FS
type: SiteQuality
SIO_000300: 8.568e0

ReadPosRankSum
type: SiteQuality
SIO_000300: -9.95e-1

ClippingRankSum
type: SiteQuality
SIO_000300: 8.27e-1

VQSLOD
type: SiteQuality
SIO_000300: -3.491e-1

QD
type: SiteQuality
SIO_000300: 1.403e1

BaseQRankSum
type: SiteQuality
SIO_000300: 2.57e0

DP
type: SiteQuality
SIO_000300: 1.662184e6

InbreedingCoeff
type: SiteQuality
SIO_000300: -3.0e-4

MQRankSum
type: SiteQuality
SIO_000300: -5.14e-1

MQ
type: SiteQuality
SIO_000300: 5.975e1

GenotypeQuality
all individuals: 18
bin: 1.75e1
variant carriers: 0

GenotypeQuality
all individuals: 197
bin: 8.75e1
variant carriers: 0

GenotypeQuality
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bin: 3.75e1
variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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bin: 3.25e1
variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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bin: 1.25e1
variant carriers: 0

GenotypeQuality
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variant carriers: 1

GenotypeQuality
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variant carriers: 0

GenotypeQuality
all individuals: 14
bin: 4.25e1
variant carriers: 0

GenotypeQuality
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GenotypeQuality
all individuals: 2000
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variant carriers: 0

GenotypeQuality
all individuals: 45214
bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 9268
bin: 6.75e1
variant carriers: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11540
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 898
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.510482750286992e-5
allele num: 66204
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10328
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8638
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6548
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16506
num of homozygotes: 0

VQSLOD
type: SiteQuality
SIO_000300: 4.03e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: -3.0e-4

FS
type: SiteQuality
SIO_000300: 3.963e0

MQ
type: SiteQuality
SIO_000300: 5.935e1

QD
type: SiteQuality
SIO_000300: 1.133e1

BaseQRankSum
type: SiteQuality
SIO_000300: -2.379e0

MQRankSum
type: SiteQuality
SIO_000300: 1.06e0

ClippingRankSum
type: SiteQuality
SIO_000300: -1.538e0

DP
type: SiteQuality
SIO_000300: 1.662033e6

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.4e0

GenotypeQuality
all individuals: 4
bin: 2.5e0
variant carriers: 0

GenotypeQuality
all individuals: 72
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 13
bin: 1.25e1
variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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bin: 3.75e1
variant carriers: 0

GenotypeQuality
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variant carriers: 1

GenotypeQuality
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bin: 4.25e1
variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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bin: 6.25e1
variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
all individuals: 194
bin: 8.75e1
variant carriers: 0

GenotypeQuality
all individuals: 9265
bin: 6.75e1
variant carriers: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66194
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 898
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10326
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6550
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11538
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8638
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.058403004967891e-5
allele num: 16506
num of homozygotes: 0

DP
type: SiteQuality
SIO_000300: 1.661506e6

MQRankSum
type: SiteQuality
SIO_000300: -5.33e-1

BaseQRankSum
type: SiteQuality
SIO_000300: -1.313e0

ReadPosRankSum
type: SiteQuality
SIO_000300: 2.4e-1

VQSLOD
type: SiteQuality
SIO_000300: 9.45e-1

ClippingRankSum
type: SiteQuality
SIO_000300: -7.92e-1

FS
type: SiteQuality
SIO_000300: 1.404e0

QD
type: SiteQuality
SIO_000300: 1.435e1

MQ
type: SiteQuality
SIO_000300: 5.965e1

InbreedingCoeff
type: SiteQuality
SIO_000300: 4.0e-4

GenotypeQuality
all individuals: 13
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 517
bin: 2.25e1
variant carriers: 0

GenotypeQuality
all individuals: 13
bin: 1.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1998
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variant carriers: 0

GenotypeQuality
all individuals: 4
bin: 2.5e0
variant carriers: 0

GenotypeQuality
all individuals: 57
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variant carriers: 0

GenotypeQuality
all individuals: 72
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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bin: 6.25e1
variant carriers: 0

GenotypeQuality
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bin: 3.75e1
variant carriers: 0

GenotypeQuality
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bin: 1.75e1
variant carriers: 0

GenotypeQuality
all individuals: 56
bin: 3.25e1
variant carriers: 0

GenotypeQuality
all individuals: 29
bin: 5.25e1
variant carriers: 0

GenotypeQuality
all individuals: 460
bin: 9.75e1
variant carriers: 1

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 898
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11538
num of homozygotes: 0

East Asian
type: Population
allele count: 1
allele frequency: 1.157675387821255e-4
allele num: 8638
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16506
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10326
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6550
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 66194
num of homozygotes: 0

DP
type: SiteQuality
SIO_000300: 1.661506e6

ClippingRankSum
type: SiteQuality
SIO_000300: -7.92e-1

VQSLOD
type: SiteQuality
SIO_000300: 9.45e-1

MQ
type: SiteQuality
SIO_000300: 5.965e1

FS
type: SiteQuality
SIO_000300: 1.404e0

BaseQRankSum
type: SiteQuality
SIO_000300: -1.313e0

InbreedingCoeff
type: SiteQuality
SIO_000300: 4.0e-4

QD
type: SiteQuality
SIO_000300: 1.435e1

MQRankSum
type: SiteQuality
SIO_000300: -5.33e-1

ReadPosRankSum
type: SiteQuality
SIO_000300: 2.4e-1

GenotypeQuality
all individuals: 58
bin: 5.75e1
variant carriers: 0

GenotypeQuality
all individuals: 47
bin: 4.75e1
variant carriers: 0

GenotypeQuality
all individuals: 18
bin: 1.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1981
bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 83
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 439
bin: 9.75e1
variant carriers: 2

GenotypeQuality
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bin: 2.25e1
variant carriers: 0

GenotypeQuality
all individuals: 72
bin: 7.5e0
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GenotypeQuality
all individuals: 1796
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 190
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 73
bin: 3.25e1
variant carriers: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10314
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 894
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16506
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 2
allele frequency: 3.023431594860166e-5
allele num: 66150
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6522
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11534
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8638
num of homozygotes: 0

MQ
type: SiteQuality
SIO_000300: 6.0e1

FS
type: SiteQuality
SIO_000300: 1.2824e1

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.34e0

BaseQRankSum
type: SiteQuality
SIO_000300: -1.604e0

ClippingRankSum
type: SiteQuality
SIO_000300: 1.96e0

QD
type: SiteQuality
SIO_000300: 1.099e1

InbreedingCoeff
type: SiteQuality
SIO_000300: -5.999999999999999e-4

VQSLOD
type: SiteQuality
SIO_000300: -2.029e0

MQRankSum
type: SiteQuality
SIO_000300: 1.48e0

DP
type: SiteQuality
SIO_000300: 1.659961e6

GenotypeQuality
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bin: 6.75e1
variant carriers: 0

GenotypeQuality
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bin: 1.75e1
variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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bin: 2.5e0
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 3.25e1
variant carriers: 0

GenotypeQuality
all individuals: 185
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variant carriers: 0

GenotypeQuality
all individuals: 436
bin: 9.75e1
variant carriers: 7

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 892
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6500
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8624
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 7
allele frequency: 1.061377971858321e-4
allele num: 65952
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16484
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11510
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10282
num of homozygotes: 0

MQRankSum
type: SiteQuality
SIO_000300: 6.31e-1

DP
type: SiteQuality
SIO_000300: 1.651156e6

ReadPosRankSum
type: SiteQuality
SIO_000300: 4.99e-1

FS
type: SiteQuality
SIO_000300: 0.0e0

MQ
type: SiteQuality
SIO_000300: 6.0e1

ClippingRankSum
type: SiteQuality
SIO_000300: -2.8e-1

VQSLOD
type: SiteQuality
SIO_000300: 3.78e0

BaseQRankSum
type: SiteQuality
SIO_000300: -3.965e0

InbreedingCoeff
type: SiteQuality
SIO_000300: -5.0e-4

QD
type: SiteQuality
SIO_000300: 1.274e1

GenotypeQuality
all individuals: 21
bin: 1.25e1
variant carriers: 0

GenotypeQuality
all individuals: 15
bin: 2.5e0
variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 105
bin: 4.75e1
variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
all individuals: 667
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 6.25e1
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
all individuals: 181
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variant carriers: 0

GenotypeQuality
all individuals: 146
bin: 3.25e1
variant carriers: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6476
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 65874
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8624
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.073120369245719e-5
allele num: 16466
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10270
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 892
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11502
num of homozygotes: 0

BaseQRankSum
type: SiteQuality
SIO_000300: 5.45e0

ReadPosRankSum
type: SiteQuality
SIO_000300: 2.31e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: -5.999999999999999e-4

FS
type: SiteQuality
SIO_000300: 0.0e0

MQ
type: SiteQuality
SIO_000300: 6.0e1

ClippingRankSum
type: SiteQuality
SIO_000300: -2.11e-1

DP
type: SiteQuality
SIO_000300: 1.647593e6

VQSLOD
type: SiteQuality
SIO_000300: 2.53e0

QD
type: SiteQuality
SIO_000300: 1.547e1

MQRankSum
type: SiteQuality
SIO_000300: 5.93e-1

GenotypeQuality
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bin: 7.75e1
variant carriers: 0

GenotypeQuality
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GenotypeQuality
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bin: 7.5e0
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GenotypeQuality
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GenotypeQuality
all individuals: 132
bin: 4.75e1
variant carriers: 0

GenotypeQuality
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GenotypeQuality
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bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 15
bin: 2.5e0
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GenotypeQuality
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GenotypeQuality
all individuals: 1939
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GenotypeQuality
all individuals: 183
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GenotypeQuality
all individuals: 67
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 428
bin: 9.75e1
variant carriers: 2

GenotypeQuality
all individuals: 113
bin: 3.75e1
variant carriers: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11492
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8620
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.084945843981989e-5
allele num: 16434
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10254
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6438
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 890
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.52012647452268e-5
allele num: 65784
num of homozygotes: 0

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.69e0

DP
type: SiteQuality
SIO_000300: 1.64325e6

ClippingRankSum
type: SiteQuality
SIO_000300: -6.28e-1

FS
type: SiteQuality
SIO_000300: 6.249e0

BaseQRankSum
type: SiteQuality
SIO_000300: 1.43e0

InbreedingCoeff
type: SiteQuality
SIO_000300: -5.0e-4

QD
type: SiteQuality
SIO_000300: 1.328e1

MQRankSum
type: SiteQuality
SIO_000300: -1.41e-1

MQ
type: SiteQuality
SIO_000300: 5.937e1

VQSLOD
type: SiteQuality
SIO_000300: -2.264e-1

GenotypeQuality
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bin: 5.75e1
variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 2.25e1
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GenotypeQuality
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variant carriers: 1

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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bin: 8.25e1
variant carriers: 0

GenotypeQuality
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variant carriers: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16374
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.52401853206535e-5
allele num: 65616
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8614
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10202
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11482
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6382
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 882
num of homozygotes: 0

VQSLOD
type: SiteQuality
SIO_000300: 1.77e0

BaseQRankSum
type: SiteQuality
SIO_000300: -1.319e0

DP
type: SiteQuality
SIO_000300: 1.633771e6

FS
type: SiteQuality
SIO_000300: 1.685e0

MQRankSum
type: SiteQuality
SIO_000300: -2.15e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: -7.0e-4

ClippingRankSum
type: SiteQuality
SIO_000300: 1.07e-1

MQ
type: SiteQuality
SIO_000300: 6.0e1

QD
type: SiteQuality
SIO_000300: 1.274e1

ReadPosRankSum
type: SiteQuality
SIO_000300: -2.49e-1

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 3.75e1
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GenotypeQuality
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bin: 1.75e1
variant carriers: 0

European (Non-Finnish)
type: Population
allele count: 2
allele frequency: 3.054087896649666e-5
allele num: 65486
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11458
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16328
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 880
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10176
num of homozygotes: 0

East Asian
type: Population
allele count: 8
allele frequency: 9.304489416143289e-4
allele num: 8598
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6358
num of homozygotes: 0

QD
type: SiteQuality
SIO_000300: 1.545e1

VQSLOD
type: SiteQuality
SIO_000300: 1.38e0

ReadPosRankSum
type: SiteQuality
SIO_000300: 3.47e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: 3.0e-4

MQRankSum
type: SiteQuality
SIO_000300: -5.88e-1

BaseQRankSum
type: SiteQuality
SIO_000300: 1.52e0

ClippingRankSum
type: SiteQuality
SIO_000300: -5.600000000000001e-1

MQ
type: SiteQuality
SIO_000300: 5.971e1

FS
type: SiteQuality
SIO_000300: 3.854e0

DP
type: SiteQuality
SIO_000300: 1.624399e6

GenotypeQuality
all individuals: 25
bin: 1.25e1
variant carriers: 0

GenotypeQuality
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bin: 3.75e1
variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 12

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
all individuals: 238
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GenotypeQuality
all individuals: 101
bin: 5.75e1
variant carriers: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8598
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6360
num of homozygotes: 0

African
type: Population
allele count: 3
allele frequency: 2.94811320754717e-4
allele num: 10176
num of homozygotes: 0

Latino
type: Population
allele count: 2
allele frequency: 1.745810055865922e-4
allele num: 11456
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 882
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16330
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 7
allele frequency: 1.069159335288368e-4
allele num: 65472
num of homozygotes: 0

FS
type: SiteQuality
SIO_000300: 2.209e0

QD
type: SiteQuality
SIO_000300: 1.349e1

InbreedingCoeff
type: SiteQuality
SIO_000300: -5.0e-4

MQ
type: SiteQuality
SIO_000300: 5.952e1

MQRankSum
type: SiteQuality
SIO_000300: 1.37e-1

VQSLOD
type: SiteQuality
SIO_000300: 2.49e0

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.86e-1

DP
type: SiteQuality
SIO_000300: 1.62327e6

ClippingRankSum
type: SiteQuality
SIO_000300: -2.42e-1

BaseQRankSum
type: SiteQuality
SIO_000300: -3.015e0

GenotypeQuality
all individuals: 1714
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variant carriers: 0

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
all individuals: 167
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GenotypeQuality
all individuals: 266
bin: 3.25e1
variant carriers: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8598
num of homozygotes: 0

Latino
type: Population
allele count: 1
allele frequency: 8.732099196646873e-5
allele num: 11452
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 2
allele frequency: 3.055394298634239e-5
allele num: 65458
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16318
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10168
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6350
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 880
num of homozygotes: 0

FS
type: SiteQuality
SIO_000300: 9.728999999999999e0

ReadPosRankSum
type: SiteQuality
SIO_000300: 9.31e-1

MQRankSum
type: SiteQuality
SIO_000300: 5.54e-1

MQ
type: SiteQuality
SIO_000300: 6.0e1

VQSLOD
type: SiteQuality
SIO_000300: -1.725e0

ClippingRankSum
type: SiteQuality
SIO_000300: 6.0e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: -5.0e-4

QD
type: SiteQuality
SIO_000300: 5.36e0

BaseQRankSum
type: SiteQuality
SIO_000300: 2.02e0

DP
type: SiteQuality
SIO_000300: 1.620903e6

GenotypeQuality
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bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 208
bin: 4.75e1
variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 23

GenotypeQuality
all individuals: 1845
bin: 7.25e1
variant carriers: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6334
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11440
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 878
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10142
num of homozygotes: 0

South Asian
type: Population
allele count: 23
allele frequency: 1.411735821261969e-3
allele num: 16292
num of homozygotes: 1

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8588
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.53003457878148e-5
allele num: 65358
num of homozygotes: 0

QD
type: SiteQuality
SIO_000300: 1.384e1

ReadPosRankSum
type: SiteQuality
SIO_000300: -5.25e-1

BaseQRankSum
type: SiteQuality
SIO_000300: -2.051e0

MQRankSum
type: SiteQuality
SIO_000300: -1.48e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: 8.200000000000001e-3

MQ
type: SiteQuality
SIO_000300: 5.962e1

DP
type: SiteQuality
SIO_000300: 1.615713e6

VQSLOD
type: SiteQuality
SIO_000300: 6.41e-1

FS
type: SiteQuality
SIO_000300: 7.16e-1

ClippingRankSum
type: SiteQuality
SIO_000300: 4.22e-1

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 2.75e1
variant carriers: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 864
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.196554715578138e-5
allele num: 16138
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8560
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10076
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6268
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11394
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 65074
num of homozygotes: 0

ReadPosRankSum
type: SiteQuality
SIO_000300: -4.99e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: -9.0e-4

MQ
type: SiteQuality
SIO_000300: 5.957e1

ClippingRankSum
type: SiteQuality
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FS
type: SiteQuality
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VQSLOD
type: SiteQuality
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QD
type: SiteQuality
SIO_000300: 1.406e1

BaseQRankSum
type: SiteQuality
SIO_000300: -5.101e0

MQRankSum
type: SiteQuality
SIO_000300: 1.18e0

DP
type: SiteQuality
SIO_000300: 1.596094e6

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 2.25e1
variant carriers: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11336
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6196
num of homozygotes: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.240639041437844e-5
allele num: 16024
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Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 862
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 64780
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8520
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10016
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MQRankSum
type: SiteQuality
SIO_000300: 9.29e-1

VQSLOD
type: SiteQuality
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InbreedingCoeff
type: SiteQuality
SIO_000300: -1.1e-3

FS
type: SiteQuality
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DP
type: SiteQuality
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MQ
type: SiteQuality
SIO_000300: 6.0e1

BaseQRankSum
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ReadPosRankSum
type: SiteQuality
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ClippingRankSum
type: SiteQuality
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QD
type: SiteQuality
SIO_000300: 1.654e1

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
allele num: 8490
num of homozygotes: 0

Other
type: Population
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allele frequency: 0.0e0
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African
type: Population
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allele frequency: 2.00924251557163e-4
allele num: 9954
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11260
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 64464
num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 6144
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 15920
num of homozygotes: 0

FS
type: SiteQuality
SIO_000300: 6.542e0

MQRankSum
type: SiteQuality
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DP
type: SiteQuality
SIO_000300: 1.56864e6

ReadPosRankSum
type: SiteQuality
SIO_000300: -6.34e-1

MQ
type: SiteQuality
SIO_000300: 5.987e1

QD
type: SiteQuality
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ClippingRankSum
type: SiteQuality
SIO_000300: 6.67e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: -3.0e-4

VQSLOD
type: SiteQuality
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BaseQRankSum
type: SiteQuality
SIO_000300: 1.99e-1