17-18211608-G-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18211608
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18211608
    reference: chr 17
allele count: 1
allele frequency: 1.258178158027177e-5
allele num: 79480
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.534+19C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.352+19C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1328C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+588C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.252+119C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+588C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.466+57C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.310+57C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.543+19C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.506+57C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.314+57C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.239+57C>G
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: intron
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 86
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 514
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19998
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7488
  bin: 1.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 419
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1872
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 293
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3262
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 133
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 56
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 25264
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1031
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 9.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
num of homozygotes: 0
population: East Asian
population: South Asian
population: Latino
population: European (Finnish)
population: European (Non-Finnish)
population: African
population: Other
reference allele: G
site quality: InbreedingCoeff
site quality: MQ
site quality: MQRankSum
site quality: BaseQRankSum
site quality: FS
site quality: ClippingRankSum
site quality: QD
site quality: ReadPosRankSum
site quality: VQSLOD
site quality: DP

17-18211612-A-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18211612
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18211612
    reference: chr 17
allele count: 9
allele frequency: 1.053617419808007e-4
allele num: 85420
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.252+115T>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.543+15T>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.506+53T>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.239+53T>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.310+53T>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.466+53T>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.352+15T>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1332T>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.314+53T>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.534+15T>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+584T>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+584T>A
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: intron
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 3757
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 429
  bin: 3.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17466
  bin: 7.5e0
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 334
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 86
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6180
  bin: 1.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 1596
  bin: 1.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1103
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 295
  bin: 4.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 129
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28989
  bin: 2.25e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
num of homozygotes: 0
population: African
population: European (Finnish)
population: South Asian
population: Latino
population: European (Non-Finnish)
population: Other
population: East Asian
reference allele: A
site quality: QD
site quality: VQSLOD
site quality: ReadPosRankSum
site quality: ClippingRankSum
site quality: DP
site quality: MQRankSum
site quality: FS
site quality: InbreedingCoeff
site quality: MQ
site quality: BaseQRankSum

17-18211622-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18211622
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18211622
    reference: chr 17
allele count: 1
allele frequency: 1.002004008016032e-5
allele num: 99800
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.239+43G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.252+105G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+574G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.466+43G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.506+43G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.352+5G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.543+5G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.534+5G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+574G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.314+43G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1342G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.310+43G>A
  variant of: http://identifiers.org/hgnc/11992
canonical: false
consequence: splice region
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 447
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3198
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 100
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10539
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 38081
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1361
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 941
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5180
  bin: 2.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 86
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 302
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 183
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: c.352+5G>A
num of homozygotes: 0
population: African
population: Other
population: European (Finnish)
population: South Asian
population: East Asian
population: European (Non-Finnish)
population: Latino
reference allele: C
site quality: FS
site quality: ReadPosRankSum
site quality: InbreedingCoeff
site quality: VQSLOD
site quality: QD
site quality: ClippingRankSum
site quality: MQ
site quality: BaseQRankSum
site quality: MQRankSum
site quality: DP

17-18211629-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18211629
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18211629
    reference: chr 17
allele count: 1
allele frequency: 9.245562130177515e-6
allele num: 108160
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.310+36A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.466+36A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.506+36A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1349A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  consequence: splice_region_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.541A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.239+36A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  consequence: splice_region_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.532A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.314+36A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.252+98A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: splice_region_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.350A>G
  hgvsp: ENSP00000464338.1:p.Tyr117Cys
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+567A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+567A>G
  variant of: http://identifiers.org/hgnc/11992
canonical: false
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 456
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 129
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 183
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6057
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1849
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1442
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6540
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 86
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 544
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42918
  bin: 2.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 302
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Tyr117Cys
num of homozygotes: 0
population: African
population: Latino
population: European (Finnish)
population: Other
population: European (Non-Finnish)
population: South Asian
population: East Asian
reference allele: T
site quality: ClippingRankSum
site quality: FS
site quality: QD
site quality: DP
site quality: MQ
site quality: ReadPosRankSum
site quality: BaseQRankSum
site quality: InbreedingCoeff
site quality: VQSLOD
site quality: MQRankSum

17-18211641-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18211641
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18211641
    reference: chr 17
allele count: 7
allele frequency: 6.074596039363382e-5
allele num: 115234
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.520G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+555G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.314+24G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.529G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.338G>A
  hgvsp: ENSP00000464338.1:p.Gly113Glu
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.506+24G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.310+24G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.466+24G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.252+86G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+555G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.239+24G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1361G>A
  variant of: http://identifiers.org/hgnc/11992
canonical: false
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 1665
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 86
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7722
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 305
  bin: 4.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 187
  bin: 4.75e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 469
  bin: 3.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 3049
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 130
  bin: 5.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 45544
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 848
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Gly113Glu
num of homozygotes: 0
population: European (Finnish)
population: Other
population: South Asian
population: East Asian
population: Latino
population: European (Non-Finnish)
population: African
reference allele: C
site quality: DP
site quality: ClippingRankSum
site quality: MQRankSum
site quality: QD
site quality: MQ
site quality: InbreedingCoeff
site quality: BaseQRankSum
site quality: FS
site quality: VQSLOD
site quality: ReadPosRankSum

17-18211652-G-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18211652
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18211652
    reference: chr 17
allele count: 1
allele frequency: 8.50383522968859e-6
allele num: 117594
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.509C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.314+13C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.252+75C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.327C>G
  hgvsp: ENSP00000464338.1:p.Phe109Leu
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.239+13C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.506+13C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1372C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.310+13C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.466+13C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+544C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.518C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+544C>G
  variant of: http://identifiers.org/hgnc/11992
canonical: false
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 129
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9121
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 305
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 45386
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 184
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 464
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1880
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1796
  bin: 3.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 554
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 637
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Phe109Leu
num of homozygotes: 0
population: European (Finnish)
population: Latino
population: European (Non-Finnish)
population: East Asian
population: African
population: Other
population: South Asian
reference allele: G
site quality: MQ
site quality: ReadPosRankSum
site quality: QD
site quality: InbreedingCoeff
site quality: DP
site quality: MQRankSum
site quality: BaseQRankSum
site quality: FS
site quality: ClippingRankSum
site quality: VQSLOD

17-18211654-AT-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18211654
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18211653
    reference: chr 17
allele count: 1
allele frequency: 8.476587664869631e-6
allele num: 117972
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.310+10delA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.314+10delA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.506+10delA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.506delA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.252+72delA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: frameshift_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.324delA
  hgvsp: ENSP00000464338.1:p.Gln108HisfsTer20
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.466+10delA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+541delA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.515delA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.239+10delA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+541delA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1375delA
  variant of: http://identifiers.org/hgnc/11992
canonical: false
consequence: frameshift
filter: VQSRTrancheINDEL99.00to99.50
genotype depth: GenotypeDepth
  all individuals: 45612
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 508
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 621
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 183
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1757
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 306
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 463
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1703
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 86
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9175
  bin: 2.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Gln108HisfsTer20
num of homozygotes: 0
population: Other
population: European (Finnish)
population: East Asian
population: African
population: European (Non-Finnish)
population: Latino
population: South Asian
reference allele: AT
site quality: VQSLOD
site quality: MQ
site quality: FS
site quality: DP
site quality: MQRankSum
site quality: QD
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: InbreedingCoeff
site quality: ReadPosRankSum

17-18211671-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18211671
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18211671
    reference: chr 17
allele count: 7
allele frequency: 5.83459749612416e-5
allele num: 119974
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.252+56G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.500G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.304G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+525G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+525G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.490G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.499G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1391G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.460G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.233G>A
  hgvsp: ENSP00000462790.1:p.Arg78Gln
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.308G>A
  hgvsp: ENSP00000464338.1:p.Arg103Gln
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.308G>A
  hgvsp: ENSP00000321636.5:p.Arg103Gln
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 471
  bin: 3.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 257
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1895
  bin: 3.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 130
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 46484
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 308
  bin: 4.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 256
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 88
  bin: 5.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 9772
  bin: 2.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 185
  bin: 4.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 700
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Arg103Gln
num of homozygotes: 0
population: South Asian
population: European (Finnish)
population: European (Non-Finnish)
population: East Asian
population: African
population: Other
population: Latino
reference allele: C
site quality: DP
site quality: MQRankSum
site quality: BaseQRankSum
site quality: QD
site quality: ClippingRankSum
site quality: ReadPosRankSum
site quality: InbreedingCoeff
site quality: FS
site quality: VQSLOD
site quality: MQ

17-18211681-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18211681
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18211681
    reference: chr 17
allele count: 7
allele frequency: 5.804311774461028e-5
allele num: 120600
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.223A>G
  hgvsp: ENSP00000462790.1:p.Met75Val
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.480A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.252+46A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+515A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.298A>G
  hgvsp: ENSP00000321636.5:p.Met100Val
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1401A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.294A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.490A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.298A>G
  hgvsp: ENSP00000464338.1:p.Met100Val
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.450A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.489A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+515A>G
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 469
  bin: 3.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 0
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 56
  bin: 6.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 184
  bin: 4.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 139
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5
  bin: 9.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 129
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 168
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10039
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 46736
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 86
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 306
  bin: 4.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 399
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Met100Val
num of homozygotes: 0
population: East Asian
population: African
population: Latino
population: Other
population: European (Finnish)
population: European (Non-Finnish)
population: South Asian
reference allele: T
site quality: DP
site quality: MQ
site quality: FS
site quality: MQRankSum
site quality: BaseQRankSum
site quality: ReadPosRankSum
site quality: InbreedingCoeff
site quality: VQSLOD
site quality: ClippingRankSum
site quality: QD

17-18211692-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18211692
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18211692
    reference: chr 17
allele count: 2
allele frequency: 1.656122685568547e-5
allele num: 120764
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.479A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.287A>G
  hgvsp: ENSP00000321636.5:p.His96Arg
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.283A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.287A>G
  hgvsp: ENSP00000464338.1:p.His96Arg
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+504A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.469A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.478A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.439A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.252+35A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.212A>G
  hgvsp: ENSP00000462790.1:p.His71Arg
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+504A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1412A>G
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 129
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 155
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 467
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 46664
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1907
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 305
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 319
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 112
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 56
  bin: 6.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10217
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 7.25e1
  variant carriers: 1
genotype quality: GenotypeQuality
hgvs: p.His96Arg
num of homozygotes: 0
population: European (Finnish)
population: East Asian
population: African
population: South Asian
population: Latino
population: European (Non-Finnish)
population: Other
reference allele: T
site quality: ReadPosRankSum
site quality: MQRankSum
site quality: QD
site quality: ClippingRankSum
site quality: FS
site quality: BaseQRankSum
site quality: DP
site quality: MQ
site quality: InbreedingCoeff
site quality: VQSLOD

17-18211700-T-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18211700
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18211700
    reference: chr 17
allele count: 1
allele frequency: 8.279653579294243e-6
allele num: 120778
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.252+27A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.431A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.279A>T
  hgvsp: ENSP00000464338.1:p.Leu93Phe
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.470A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+496A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.471A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.204A>T
  hgvsp: ENSP00000462790.1:p.Leu68Phe
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.461A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.279A>T
  hgvsp: ENSP00000321636.5:p.Leu93Phe
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1420A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+496A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.275A>T
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 304
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 195
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 467
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1927
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10345
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 120
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 46477
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 86
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Leu93Phe
num of homozygotes: 0
population: European (Finnish)
population: Latino
population: East Asian
population: Other
population: European (Non-Finnish)
population: African
population: South Asian
reference allele: T
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: ReadPosRankSum
site quality: InbreedingCoeff
site quality: FS
site quality: VQSLOD
site quality: MQ
site quality: MQRankSum
site quality: DP
site quality: QD

17-18211704-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18211704
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18211704
    reference: chr 17
allele count: 2
allele frequency: 1.656150113446283e-5
allele num: 120762
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.252+23A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.275A>G
  hgvsp: ENSP00000321636.5:p.His92Arg
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.427A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.467A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.275A>G
  hgvsp: ENSP00000464338.1:p.His92Arg
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.466A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.457A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+492A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.200A>G
  hgvsp: ENSP00000462790.1:p.His67Arg
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+492A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.271A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1424A>G
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 1
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10375
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 231
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 321
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1920
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 86
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 132
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 304
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 466
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 129
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.His92Arg
num of homozygotes: 0
population: European (Non-Finnish)
population: East Asian
population: Latino
population: South Asian
population: African
population: Other
population: European (Finnish)
reference allele: T
site quality: VQSLOD
site quality: MQRankSum
site quality: BaseQRankSum
site quality: DP
site quality: FS
site quality: ClippingRankSum
site quality: MQ
site quality: QD
site quality: InbreedingCoeff
site quality: ReadPosRankSum

http://identifiers.org/exac.variant/17-18211711-A-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18211711
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18211711
    reference: chr 17
allele count: 8
allele frequency: 6.633169162396564e-5
allele num: 120606
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.460T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.268T>G
  hgvsp: ENSP00000321636.5:p.Ser90Ala
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.420T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.193T>G
  hgvsp: ENSP00000462790.1:p.Ser65Ala
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.450T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.459T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.268T>G
  hgvsp: ENSP00000464338.1:p.Ser90Ala
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.264T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1431T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+485T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+485T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.252+16T>G
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 2
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 467
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 185
  bin: 4.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 132
  bin: 5.25e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 397
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 304
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 44
  bin: 6.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 87
  bin: 5.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 141
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1915
  bin: 3.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 46147
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10427
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Ser90Ala
num of homozygotes: 0
population: East Asian
population: European (Non-Finnish)
population: Other
population: European (Finnish)
population: South Asian
population: African
population: Latino
reference allele: A
site quality: MQ
site quality: DP
site quality: VQSLOD
site quality: InbreedingCoeff
site quality: ClippingRankSum
site quality: QD
site quality: BaseQRankSum
site quality: MQRankSum
site quality: ReadPosRankSum
site quality: FS

17-18211723-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18211723
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18211723
    reference: chr 17
allele count: 1
allele frequency: 8.321544478655239e-6
allele num: 120170
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.181A>G
  hgvsp: ENSP00000462790.1:p.Met61Val
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.256A>G
  hgvsp: ENSP00000321636.5:p.Met86Val
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.438A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.252+4A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+473A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.256A>G
  hgvsp: ENSP00000464338.1:p.Met86Val
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.252A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+473A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.447A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.448A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.408A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1443A>G
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 10390
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 129
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 86
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 611
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 815
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 256
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 184
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 474
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 309
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1923
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Met86Val
num of homozygotes: 0
population: Other
population: East Asian
population: African
population: Latino
population: European (Non-Finnish)
population: South Asian
population: European (Finnish)
reference allele: T
site quality: FS
site quality: MQRankSum
site quality: VQSLOD
site quality: BaseQRankSum
site quality: MQ
site quality: ClippingRankSum
site quality: InbreedingCoeff
site quality: DP
site quality: QD
site quality: ReadPosRankSum

17-18211728-A-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18211728
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18211728
    reference: chr 17
allele count: 1
allele frequency: 8.343484572897024e-6
allele num: 119854
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.443T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+468T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: splice_region_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.251T>C
  hgvsp: ENSP00000464493.1:p.Met84Thr
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1448T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.251T>C
  hgvsp: ENSP00000464338.1:p.Met84Thr
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.442T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.433T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.251T>C
  hgvsp: ENSP00000321636.5:p.Met84Thr
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.247T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+468T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.176T>C
  hgvsp: ENSP00000462790.1:p.Met59Thr
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.403T>C
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 766
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 305
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1921
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 44797
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 324
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10431
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 129
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1128
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 470
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 185
  bin: 4.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Met84Thr
num of homozygotes: 0
population: Latino
population: South Asian
population: African
population: East Asian
population: European (Non-Finnish)
population: Other
population: European (Finnish)
reference allele: A
site quality: MQ
site quality: FS
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: QD
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: DP
site quality: ReadPosRankSum
site quality: VQSLOD

17-18211731-G-GT
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18211731
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18211732
    reference: chr 17
allele count: 1
allele frequency: 8.370862701109976e-6
allele num: 119462
alternate allele: GT
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.438dupA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1452dupA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.439dupA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: frameshift_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.247dupA
  hgvsp: ENSP00000464493.1:p.Thr83AsnfsTer11
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: frameshift_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.172dupA
  hgvsp: ENSP00000462790.1:p.Thr58AsnfsTer15
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+464dupA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: frameshift_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.247dupA
  hgvsp: ENSP00000464338.1:p.Thr83AsnfsTer15
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.399dupA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+464dupA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.243dupA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: frameshift_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.247dupA
  hgvsp: ENSP00000321636.5:p.Thr83AsnfsTer15
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.429dupA
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: frameshift
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 428
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 306
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 185
  bin: 4.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 954
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1943
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 86
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10386
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1543
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 44106
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Thr83AsnfsTer15
num of homozygotes: 0
population: Latino
population: Other
population: European (Non-Finnish)
population: African
population: South Asian
population: European (Finnish)
population: East Asian
reference allele: G
site quality: QD
site quality: ClippingRankSum
site quality: MQRankSum
site quality: DP
site quality: BaseQRankSum
site quality: FS
site quality: VQSLOD
site quality: MQ
site quality: InbreedingCoeff
site quality: ReadPosRankSum

17-18211732-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18211732
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18211732
    reference: chr 17
allele count: 2
allele frequency: 1.674172540221995e-5
allele num: 119462
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.247A>G
  hgvsp: ENSP00000464493.1:p.Thr83Ala
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+464A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.243A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.247A>G
  hgvsp: ENSP00000464338.1:p.Thr83Ala
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.399A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.429A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.439A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+464A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.247A>G
  hgvsp: ENSP00000321636.5:p.Thr83Ala
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.438A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1452A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.172A>G
  hgvsp: ENSP00000462790.1:p.Thr58Ala
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1551
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1935
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 7.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 307
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 130
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 43
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 424
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 470
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10415
  bin: 2.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 186
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 44078
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 86
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Thr83Ala
num of homozygotes: 0
population: South Asian
population: African
population: European (Non-Finnish)
population: Latino
population: East Asian
population: Other
population: European (Finnish)
reference allele: T
site quality: FS
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: ReadPosRankSum
site quality: MQ
site quality: VQSLOD
site quality: DP
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: QD

17-18211736-A-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18211736
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18211736
    reference: chr 17
allele count: 25
allele frequency: 2.106469388786842e-4
allele num: 118682
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  consequence: splice_region_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.168T>C
  hgvsp: ENST00000580095.1:c.168T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  consequence: splice_region_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.243T>C
  hgvsp: ENST00000321105.5:c.243T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  consequence: splice_region_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.425T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  consequence: splice_region_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.239T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  consequence: splice_region_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.243T>C
  hgvsp: ENST00000461127.1:c.243T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  consequence: splice_region_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.243T>C
  hgvsp: ENST00000585031.1:c.243T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+460T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  consequence: splice_region_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.395T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  consequence: splice_region_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.435T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  consequence: splice_region_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.434T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+460T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1456T>C
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: splice region
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 58
  bin: 6.25e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 469
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42573
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20
  bin: 7.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 2632
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1336
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 187
  bin: 4.75e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 308
  bin: 4.25e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 10161
  bin: 2.75e1
  variant carriers: 5
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 9.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 678
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1969
  bin: 3.25e1
  variant carriers: 6
genotype quality: GenotypeQuality
hgvs: c.243T>C
num of homozygotes: 0
population: African
population: South Asian
population: Latino
population: Other
population: East Asian
population: European (Finnish)
population: European (Non-Finnish)
reference allele: A
site quality: ReadPosRankSum
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: InbreedingCoeff
site quality: FS
site quality: MQ
site quality: MQRankSum
site quality: QD
site quality: DP
site quality: VQSLOD

17-18211737-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18211737
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18211737
    reference: chr 17
allele count: 1
allele frequency: 8.425451604205986e-6
allele num: 118688
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+459A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: splice_region_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.167A>G
  hgvsp: ENSP00000462790.1:p.Asn56Ser
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1457A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: splice_region_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.242A>G
  hgvsp: ENSP00000464338.1:p.Asn81Ser
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: missense_variant
  consequence: splice_region_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.242A>G
  hgvsp: ENSP00000321636.5:p.Asn81Ser
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+459A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  consequence: splice_region_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.394A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  consequence: splice_region_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.433A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  consequence: splice_region_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.434A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: splice_region_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.242A>G
  hgvsp: ENSP00000464493.1:p.Asn81Ser
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  consequence: splice_region_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.424A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  consequence: splice_region_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.238A>G
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 10186
  bin: 2.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 184
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1951
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 129
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1338
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42578
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 86
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 308
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 674
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Asn81Ser
num of homozygotes: 0
population: African
population: Other
population: South Asian
population: East Asian
population: European (Finnish)
population: Latino
population: European (Non-Finnish)
reference allele: T
site quality: ReadPosRankSum
site quality: VQSLOD
site quality: QD
site quality: ClippingRankSum
site quality: InbreedingCoeff
site quality: BaseQRankSum
site quality: MQRankSum
site quality: MQ
site quality: FS
site quality: DP

17-18211741-G-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18211741
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18211741
    reference: chr 17
allele count: 4
allele frequency: 3.387533875338753e-5
allele num: 118080
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.433-3C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.423-3C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.241-3C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.241-3C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.241-3C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.432-3C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.166-3C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1461C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+455C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+455C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.237-3C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.393-3C>G
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: splice region
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 481
  bin: 3.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 10012
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1975
  bin: 3.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3477
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 129
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 87
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 41422
  bin: 2.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 21
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 834
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: c.241-3C>G
num of homozygotes: 0
population: Latino
population: European (Non-Finnish)
population: African
population: East Asian
population: Other
population: South Asian
population: European (Finnish)
reference allele: G
site quality: QD
site quality: ReadPosRankSum
site quality: MQ
site quality: FS
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: ClippingRankSum
site quality: VQSLOD
site quality: BaseQRankSum
site quality: DP

17-18211744-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18211744
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18211744
    reference: chr 17
allele count: 1
allele frequency: 8.499498529586754e-6
allele num: 117654
alternate allele: C
annotation: Annotation
  canonical: true
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.241-6A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.241-6A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.166-6A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.237-6A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.423-6A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.432-6A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.433-6A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+452A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1464A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.241-6A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+452A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.393-6A>G
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: splice region
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 40348
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 184
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 129
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4268
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1017
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 86
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9949
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 472
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1832
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 305
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: c.241-6A>G
num of homozygotes: 0
population: European (Finnish)
population: Other
population: Latino
population: East Asian
population: European (Non-Finnish)
population: South Asian
population: African
reference allele: T
site quality: ClippingRankSum
site quality: FS
site quality: VQSLOD
site quality: MQRankSum
site quality: QD
site quality: DP
site quality: InbreedingCoeff
site quality: MQ
site quality: BaseQRankSum
site quality: ReadPosRankSum

17-18211767-TTA-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18211767
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18211765
    reference: chr 17
allele count: 1
allele frequency: 8.817253601848096e-6
allele num: 113414
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.393-31_393-30delTA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.241-31_241-30delTA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.241-31_241-30delTA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.433-31_433-30delTA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.432-31_432-30delTA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.423-31_423-30delTA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1489_181-1488delTA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+427_240+428delTA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.237-31_237-30delTA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.241-31_241-30delTA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.166-31_166-30delTA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+427_29+428delTA
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: intron
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 23222
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 462
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 185
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1481
  bin: 3.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 15966
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 252
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 86
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3568
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8654
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 129
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 304
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
num of homozygotes: 0
population: Other
population: European (Non-Finnish)
population: European (Finnish)
population: Latino
population: African
population: East Asian
population: South Asian
reference allele: TTA
site quality: MQRankSum
site quality: QD
site quality: VQSLOD
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: InbreedingCoeff
site quality: MQ
site quality: FS
site quality: DP
site quality: ReadPosRankSum

17-18211771-T-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18211771
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18211771
    reference: chr 17
allele count: 1
allele frequency: 8.858337467224152e-6
allele num: 112888
alternate allele: A
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.241-33A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.433-33A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.432-33A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.241-33A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.393-33A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+425A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1491A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.237-33A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.241-33A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.423-33A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+425A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.166-33A>T
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: intron
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 3779
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 451
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1389
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16647
  bin: 1.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 5614
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 184
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 318
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 129
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20757
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10888
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 305
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
num of homozygotes: 0
population: Other
population: East Asian
population: Latino
population: South Asian
population: African
population: European (Finnish)
population: European (Non-Finnish)
reference allele: T
site quality: InbreedingCoeff
site quality: MQRankSum
site quality: FS
site quality: ReadPosRankSum
site quality: MQ
site quality: DP
site quality: VQSLOD
site quality: QD
site quality: BaseQRankSum
site quality: ClippingRankSum

17-18211777-T-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18211777
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18211777
    reference: chr 17
allele count: 6
allele frequency: 5.390641845755768e-5
allele num: 111304
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.237-39A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.423-39A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1497A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.166-39A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.241-39A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.433-39A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+419A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.432-39A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.393-39A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.241-39A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+419A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.241-39A>C
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: intron
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 304
  bin: 4.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 15172
  bin: 1.75e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 12
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16709
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 86
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 42
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1282
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16603
  bin: 2.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 421
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 453
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4385
  bin: 7.5e0
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4814
  bin: 2.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 129
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 55
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
num of homozygotes: 0
population: African
population: Latino
population: East Asian
population: European (Non-Finnish)
population: South Asian
population: European (Finnish)
population: Other
reference allele: T
site quality: DP
site quality: ClippingRankSum
site quality: InbreedingCoeff
site quality: MQ
site quality: VQSLOD
site quality: MQRankSum
site quality: ReadPosRankSum
site quality: FS
site quality: QD
site quality: BaseQRankSum

17-18212154-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18212154
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18212154
    reference: chr 17
allele count: 1
allele frequency: 1.207962891379977e-5
allele num: 82784
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+42A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.165+42A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.432+42A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.240+42A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.316A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.236+42A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.392+42A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1874A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.422+42A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+42A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.240+42A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.431+42A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.240+42A>G
  variant of: http://identifiers.org/hgnc/11992
canonical: false
consequence: non coding transcript exon
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 164
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8627
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 109
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 77
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 463
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 59
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 75
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3302
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1423
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 253
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15824
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 35
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9911
  bin: 2.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15683
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
num of homozygotes: 0
population: African
population: South Asian
population: East Asian
population: Other
population: Latino
population: European (Finnish)
population: European (Non-Finnish)
reference allele: T
site quality: ReadPosRankSum
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: QD
site quality: MQ
site quality: FS
site quality: VQSLOD
site quality: DP
site quality: BaseQRankSum
site quality: ClippingRankSum

17-18212155-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18212155
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18212155
    reference: chr 17
allele count: 1
allele frequency: 1.20598166907863e-5
allele num: 82920
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.431+41A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.165+41A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.315A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.422+41A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.432+41A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+41A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.392+41A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.240+41A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.236+41A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+41A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1875A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.240+41A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.240+41A>G
  variant of: http://identifiers.org/hgnc/11992
canonical: false
consequence: non coding transcript exon
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 460
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15744
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 77
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4487
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3240
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 164
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 254
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 59
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1435
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 62
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10428
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8162
  bin: 1.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 15725
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 35
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
num of homozygotes: 0
population: African
population: South Asian
population: Latino
population: European (Non-Finnish)
population: East Asian
population: European (Finnish)
population: Other
reference allele: T
site quality: MQ
site quality: VQSLOD
site quality: MQRankSum
site quality: BaseQRankSum
site quality: DP
site quality: FS
site quality: ReadPosRankSum
site quality: ClippingRankSum
site quality: QD
site quality: InbreedingCoeff

17-18212157-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18212157
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18212157
    reference: chr 17
allele count: 1
allele frequency: 1.210126337189603e-5
allele num: 82636
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.313G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.240+39G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.165+39G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+39G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.422+39G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+39G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.240+39G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.431+39G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.432+39G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.240+39G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.392+39G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.236+39G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1877G>A
  variant of: http://identifiers.org/hgnc/11992
canonical: false
consequence: non coding transcript exon
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 109
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15404
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3064
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15814
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 464
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6891
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 164
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1470
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11917
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 62
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 77
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 35
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 59
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
num of homozygotes: 0
population: European (Finnish)
population: Other
population: South Asian
population: East Asian
population: African
population: Latino
population: European (Non-Finnish)
reference allele: C
site quality: VQSLOD
site quality: ClippingRankSum
site quality: MQRankSum
site quality: MQ
site quality: InbreedingCoeff
site quality: DP
site quality: BaseQRankSum
site quality: FS
site quality: ReadPosRankSum
site quality: QD

17-18212158-T-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18212158
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18212158
    reference: chr 17
allele count: 1
allele frequency: 1.204296931451419e-5
allele num: 83036
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.431+38A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.240+38A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.236+38A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.432+38A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.165+38A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.240+38A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+38A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.240+38A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.422+38A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+38A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.392+38A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1878A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.312A>T
  variant of: http://identifiers.org/hgnc/11992
canonical: false
consequence: non coding transcript exon
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 77
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2989
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1469
  bin: 3.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 462
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 164
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6273
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 75
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 59
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15132
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12783
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15875
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 62
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 109
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
num of homozygotes: 0
population: Other
population: African
population: East Asian
population: South Asian
population: European (Non-Finnish)
population: Latino
population: European (Finnish)
reference allele: T
site quality: FS
site quality: VQSLOD
site quality: ReadPosRankSum
site quality: MQ
site quality: InbreedingCoeff
site quality: BaseQRankSum
site quality: DP
site quality: QD
site quality: MQRankSum
site quality: ClippingRankSum

17-18212164-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18212164
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18212164
    reference: chr 17
allele count: 3
allele frequency: 3.587401047521106e-5
allele num: 83626
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.392+32A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.422+32A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.306A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.240+32A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+32A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+32A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.431+32A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.240+32A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.236+32A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.165+32A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.240+32A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.432+32A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1884A>G
  variant of: http://identifiers.org/hgnc/11992
canonical: false
consequence: non coding transcript exon
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 62
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5115
  bin: 2.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 16703
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13300
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 109
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16097
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3989
  bin: 1.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 252
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 77
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2524
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 462
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1518
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 164
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
num of homozygotes: 0
population: Other
population: East Asian
population: Latino
population: South Asian
population: African
population: European (Finnish)
population: European (Non-Finnish)
reference allele: T
site quality: ClippingRankSum
site quality: InbreedingCoeff
site quality: DP
site quality: QD
site quality: FS
site quality: VQSLOD
site quality: ReadPosRankSum
site quality: MQRankSum
site quality: MQ
site quality: BaseQRankSum

17-18212169-A-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18212169
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18212169
    reference: chr 17
allele count: 1
allele frequency: 1.184048498626504e-5
allele num: 84456
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.422+27T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.432+27T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.240+27T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.240+27T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.431+27T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.236+27T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.392+27T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.165+27T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.301T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+27T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+27T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.240+27T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1889T>C
  variant of: http://identifiers.org/hgnc/11992
canonical: false
consequence: non coding transcript exon
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19743
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 457
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2102
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11400
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 164
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5448
  bin: 2.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 1548
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2807
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 62
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16212
  bin: 7.5e0
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 75
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 109
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 252
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
num of homozygotes: 0
population: African
population: Latino
population: Other
population: East Asian
population: European (Non-Finnish)
population: South Asian
population: European (Finnish)
reference allele: A
site quality: ClippingRankSum
site quality: DP
site quality: FS
site quality: ReadPosRankSum
site quality: VQSLOD
site quality: MQ
site quality: MQRankSum
site quality: QD
site quality: BaseQRankSum
site quality: InbreedingCoeff

17-18212172-T-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18212172
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18212172
    reference: chr 17
allele count: 17
allele frequency: 2.003866283181668e-4
allele num: 84836
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.432+24A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.392+24A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.236+24A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.422+24A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.240+24A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.165+24A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.431+24A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+24A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.298A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.240+24A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.240+24A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1892A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+24A>C
  variant of: http://identifiers.org/hgnc/11992
canonical: false
consequence: non coding transcript exon
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 252
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 62
  bin: 6.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2353
  bin: 1.75e1
  variant carriers: 4
genotype depth: GenotypeDepth
  all individuals: 16175
  bin: 7.5e0
  variant carriers: 4
genotype depth: GenotypeDepth
  all individuals: 1900
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 461
  bin: 3.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 10324
  bin: 1.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 77
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21329
  bin: 2.25e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 109
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 166
  bin: 4.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 5606
  bin: 2.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 59
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
num of homozygotes: 0
population: Latino
population: South Asian
population: African
population: European (Non-Finnish)
population: East Asian
population: Other
population: European (Finnish)
reference allele: T
site quality: DP
site quality: VQSLOD
site quality: MQRankSum
site quality: BaseQRankSum
site quality: FS
site quality: ClippingRankSum
site quality: ReadPosRankSum
site quality: QD
site quality: MQ
site quality: InbreedingCoeff

17-18212173-T-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18212173
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18212173
    reference: chr 17
allele count: 17
allele frequency: 2.000847417729862e-4
allele num: 84964
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.236+23A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1893A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.297A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.240+23A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.240+23A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.240+23A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+23A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.165+23A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+23A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.422+23A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.432+23A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.392+23A>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.431+23A>T
  variant of: http://identifiers.org/hgnc/11992
canonical: false
consequence: non coding transcript exon
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 5641
  bin: 2.75e1
  variant carriers: 4
genotype depth: GenotypeDepth
  all individuals: 60
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 35
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16166
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 164
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 462
  bin: 3.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 21586
  bin: 2.25e1
  variant carriers: 4
genotype depth: GenotypeDepth
  all individuals: 2321
  bin: 1.75e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 10125
  bin: 1.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 61
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 109
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 254
  bin: 4.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 72
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1849
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
num of homozygotes: 1
population: European (Finnish)
population: Latino
population: Other
population: European (Non-Finnish)
population: African
population: South Asian
population: East Asian
reference allele: T
site quality: VQSLOD
site quality: FS
site quality: MQRankSum
site quality: ClippingRankSum
site quality: MQ
site quality: ReadPosRankSum
site quality: DP
site quality: InbreedingCoeff
site quality: QD
site quality: BaseQRankSum

17-18212193-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18212193
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18212193
    reference: chr 17
allele count: 1
allele frequency: 1.108721200966805e-5
allele num: 90194
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.422+3A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.432+3A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.240+3A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.392+3A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.240+3A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.277A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.431+3A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.29+3A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.240+3A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.165+3A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.240+3A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1913A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.236+3A>G
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: splice region
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 109
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 872
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 72
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 78
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 459
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 948
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1676
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14625
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4822
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29470
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: c.240+3A>G
num of homozygotes: 0
population: European (Non-Finnish)
population: Latino
population: European (Finnish)
population: African
population: Other
population: South Asian
population: East Asian
reference allele: T
site quality: InbreedingCoeff
site quality: BaseQRankSum
site quality: ReadPosRankSum
site quality: MQ
site quality: VQSLOD
site quality: QD
site quality: FS
site quality: MQRankSum
site quality: ClippingRankSum
site quality: DP

17-18212206-A-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18212206
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18212206
    reference: chr 17
allele count: 1
allele frequency: 1.088162963285382e-5
allele num: 91898
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.230T>A
  hgvsp: ENSP00000462378.1:p.Leu77Gln
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1926T>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.226T>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.230T>A
  hgvsp: ENSP00000464338.1:p.Leu77Gln
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.155T>A
  hgvsp: ENSP00000462790.1:p.Leu52Gln
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.382T>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.230T>A
  hgvsp: ENSP00000321636.5:p.Leu77Gln
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.19T>A
  hgvsp: ENSP00000442336.1:p.Cys7Ser
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.421T>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.230T>A
  hgvsp: ENSP00000464493.1:p.Leu77Gln
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.422T>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.412T>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.264T>A
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 30256
  bin: 2.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 742
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1709
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 457
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 163
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 829
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4261
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 109
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13911
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 253
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 60
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7588
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Leu77Gln
num of homozygotes: 0
population: European (Non-Finnish)
population: Other
population: African
population: South Asian
population: Latino
population: East Asian
population: European (Finnish)
reference allele: A
site quality: DP
site quality: VQSLOD
site quality: ClippingRankSum
site quality: MQRankSum
site quality: MQ
site quality: ReadPosRankSum
site quality: InbreedingCoeff
site quality: BaseQRankSum
site quality: FS
site quality: QD

17-18212209-T-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18212209
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18212209
    reference: chr 17
allele count: 1
allele frequency: 1.088945030054883e-5
allele num: 91832
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.16A>C
  hgvsp: ENSP00000442336.1:p.Ile6Leu
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.227A>C
  hgvsp: ENSP00000464493.1:p.His76Pro
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1929A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.227A>C
  hgvsp: ENSP00000462378.1:p.His76Pro
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.152A>C
  hgvsp: ENSP00000462790.1:p.His51Pro
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.223A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.261A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.409A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.419A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.227A>C
  hgvsp: ENSP00000464338.1:p.His76Pro
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.227A>C
  hgvsp: ENSP00000321636.5:p.His76Pro
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.418A>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.379A>C
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 7650
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 61
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1696
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 60
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 773
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 109
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 35
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13945
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4459
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29934
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 163
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 253
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 842
  bin: 1.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
hgvs: p.His76Pro
num of homozygotes: 0
population: East Asian
population: European (Finnish)
population: African
population: Other
population: Latino
population: South Asian
population: European (Non-Finnish)
reference allele: T
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: MQ
site quality: BaseQRankSum
site quality: VQSLOD
site quality: ClippingRankSum
site quality: FS
site quality: DP
site quality: QD
site quality: ReadPosRankSum

17-18212214-A-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18212214
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18212214
    reference: chr 17
allele count: 1
allele frequency: 1.094331363536879e-5
allele num: 91380
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.413T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.222T>C
  hgvsp: ENST00000582981.1:c.222T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.11T>C
  hgvsp: ENSP00000442336.1:p.Ile4Thr
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.222T>C
  hgvsp: ENST00000585031.1:c.222T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.256T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.222T>C
  hgvsp: ENST00000461127.1:c.222T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.222T>C
  hgvsp: ENST00000321105.5:c.222T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.404T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.147T>C
  hgvsp: ENST00000580095.1:c.147T>C(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1934T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.414T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.218T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.374T>C
  variant of: http://identifiers.org/hgnc/11992
canonical: false
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 855
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 110
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 35
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 253
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7734
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1698
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 78
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 457
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 60
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 60
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 907
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 163
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Ile4Thr
num of homozygotes: 0
population: Latino
population: South Asian
population: Other
population: East Asian
population: European (Finnish)
population: European (Non-Finnish)
population: African
reference allele: A
site quality: InbreedingCoeff
site quality: QD
site quality: BaseQRankSum
site quality: FS
site quality: MQRankSum
site quality: VQSLOD
site quality: ClippingRankSum
site quality: ReadPosRankSum
site quality: MQ
site quality: DP

17-18212220-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18212220
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18212220
    reference: chr 17
allele count: 1
allele frequency: 1.107002900347599e-5
allele num: 90334
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.141A>G
  hgvsp: ENST00000580095.1:c.141A>G(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1940A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.216A>G
  hgvsp: ENST00000585031.1:c.216A>G(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.216A>G
  hgvsp: ENST00000321105.5:c.216A>G(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.408A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.398A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.5A>G
  hgvsp: ENSP00000442336.1:p.Asn2Ser
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.407A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.216A>G
  hgvsp: ENST00000582981.1:c.216A>G(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.216A>G
  hgvsp: ENST00000461127.1:c.216A>G(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.250A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.368A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.212A>G
  variant of: http://identifiers.org/hgnc/11992
canonical: false
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 1694
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27350
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 455
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 35
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6074
  bin: 1.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 109
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 163
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1064
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7775
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 966
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14365
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Asn2Ser
num of homozygotes: 0
population: European (Non-Finnish)
population: East Asian
population: African
population: Latino
population: South Asian
population: European (Finnish)
population: Other
reference allele: T
site quality: DP
site quality: ClippingRankSum
site quality: VQSLOD
site quality: InbreedingCoeff
site quality: MQRankSum
site quality: FS
site quality: QD
site quality: MQ
site quality: BaseQRankSum
site quality: ReadPosRankSum

17-18212221-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18212221
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18212221
    reference: chr 17
allele count: 1
allele frequency: 1.106684373616645e-5
allele num: 90360
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.407A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.397A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1941A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.215A>G
  hgvsp: ENSP00000321636.5:p.Glu72Gly
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.215A>G
  hgvsp: ENSP00000464493.1:p.Glu72Gly
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.4A>G
  hgvsp: ENSP00000442336.1:p.Asn2Asp
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.215A>G
  hgvsp: ENSP00000462378.1:p.Glu72Gly
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.140A>G
  hgvsp: ENSP00000462790.1:p.Glu47Gly
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.406A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.215A>G
  hgvsp: ENSP00000464338.1:p.Glu72Gly
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.211A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.367A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.249A>G
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 72
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7795
  bin: 2.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 253
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 78
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6072
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 60
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 35
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 60
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 109
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27382
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1061
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14362
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Glu72Gly
num of homozygotes: 0
population: East Asian
population: Latino
population: South Asian
population: African
population: Other
population: European (Finnish)
population: European (Non-Finnish)
reference allele: T
site quality: InbreedingCoeff
site quality: VQSLOD
site quality: ReadPosRankSum
site quality: MQRankSum
site quality: QD
site quality: MQ
site quality: FS
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: DP

17-18212224-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18212224
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18212224
    reference: chr 17
allele count: 1
allele frequency: 1.116919090381093e-5
allele num: 89532
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.394A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: start_lost
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.1A>G
  hgvsp: ENSP00000442336.1:p.Met1?
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.212A>G
  hgvsp: ENSP00000462378.1:p.Tyr71Cys
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1944A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.212A>G
  hgvsp: ENSP00000464493.1:p.Tyr71Cys
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.246A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.364A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.137A>G
  hgvsp: ENSP00000462790.1:p.Tyr46Cys
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.208A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.212A>G
  hgvsp: ENSP00000464338.1:p.Tyr71Cys
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.212A>G
  hgvsp: ENSP00000321636.5:p.Tyr71Cys
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.403A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.404A>G
  variant of: http://identifiers.org/hgnc/11992
canonical: false
consequence: start lost
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 109
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 253
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 455
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1192
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 35
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1007
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14611
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 78
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 60
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 26016
  bin: 2.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 1702
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7836
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6921
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Met1?
num of homozygotes: 0
population: East Asian
population: Latino
population: Other
population: African
population: European (Non-Finnish)
population: European (Finnish)
population: South Asian
reference allele: T
site quality: InbreedingCoeff
site quality: DP
site quality: FS
site quality: MQRankSum
site quality: VQSLOD
site quality: ReadPosRankSum
site quality: BaseQRankSum
site quality: MQ
site quality: ClippingRankSum
site quality: QD

17-18212233-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18212233
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18212233
    reference: chr 17
allele count: 1
allele frequency: 1.162790697674419e-5
allele num: 86000
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.394A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.203A>G
  hgvsp: ENSP00000464493.1:p.Asn68Ser
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: 5_prime_UTR_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-9A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.237A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.203A>G
  hgvsp: ENSP00000462378.1:p.Asn68Ser
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.385A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.203A>G
  hgvsp: ENSP00000321636.5:p.Asn68Ser
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.395A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.199A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.128A>G
  hgvsp: ENSP00000462790.1:p.Asn43Ser
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.203A>G
  hgvsp: ENSP00000464338.1:p.Asn68Ser
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1953A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.355A>G
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 1432
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 60
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 59
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1807
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 78
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 455
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 21311
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7560
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 253
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 9793
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 109
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15690
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 35
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Asn68Ser
num of homozygotes: 0
population: South Asian
population: African
population: East Asian
population: European (Finnish)
population: Latino
population: European (Non-Finnish)
population: Other
reference allele: T
site quality: BaseQRankSum
site quality: DP
site quality: MQ
site quality: VQSLOD
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: FS
site quality: ReadPosRankSum
site quality: QD
site quality: ClippingRankSum

17-18212236-A-G
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18212236
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18212236
    reference: chr 17
allele count: 1
allele frequency: 1.168770453482936e-5
allele num: 85560
alternate allele: G
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.200T>C
  hgvsp: ENSP00000464338.1:p.Phe67Ser
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.196T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.392T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.382T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.200T>C
  hgvsp: ENSP00000462378.1:p.Phe67Ser
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.200T>C
  hgvsp: ENSP00000464493.1:p.Phe67Ser
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.352T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.125T>C
  hgvsp: ENSP00000462790.1:p.Phe42Ser
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.200T>C
  hgvsp: ENSP00000321636.5:p.Phe67Ser
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1956T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.391T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.234T>C
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: 5_prime_UTR_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-12T>C
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 15856
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10120
  bin: 1.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 253
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1917
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 78
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1393
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 164
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 35
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 109
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 20812
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1656
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7513
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Phe67Ser
num of homozygotes: 0
population: South Asian
population: African
population: Latino
population: European (Non-Finnish)
population: European (Finnish)
population: Other
population: East Asian
reference allele: A
site quality: QD
site quality: ClippingRankSum
site quality: ReadPosRankSum
site quality: MQ
site quality: DP
site quality: MQRankSum
site quality: VQSLOD
site quality: FS
site quality: BaseQRankSum
site quality: InbreedingCoeff

17-18212246-G-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18212246
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18212246
    reference: chr 17
allele count: 1
allele frequency: 1.246976082998728e-5
allele num: 80194
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.190C>G
  hgvsp: ENSP00000462378.1:p.Leu64Val
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.190C>G
  hgvsp: ENSP00000321636.5:p.Leu64Val
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.224C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: 5_prime_UTR_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-22C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.190C>G
  hgvsp: ENSP00000464493.1:p.Leu64Val
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.190C>G
  hgvsp: ENSP00000464338.1:p.Leu64Val
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1966C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.382C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.186C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.115C>G
  hgvsp: ENSP00000462790.1:p.Leu39Val
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.372C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.381C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.342C>G
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 32
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1927
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 253
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13743
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 164
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6679
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14917
  bin: 2.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 17027
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 35
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 452
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3277
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1629
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 78
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Leu64Val
num of homozygotes: 0
population: East Asian
population: European (Non-Finnish)
population: European (Finnish)
population: African
population: South Asian
population: Latino
population: Other
reference allele: G
site quality: ReadPosRankSum
site quality: MQ
site quality: VQSLOD
site quality: QD
site quality: FS
site quality: MQRankSum
site quality: BaseQRankSum
site quality: InbreedingCoeff
site quality: DP
site quality: ClippingRankSum

17-18212250-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18212250
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18212250
    reference: chr 17
allele count: 7
allele frequency: 9.146022786662486e-5
allele num: 76536
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.111A>G
  hgvsp: ENST00000580095.1:c.111A>G(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.338A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.368A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.377A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.186A>G
  hgvsp: ENST00000461127.1:c.186A>G(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.186A>G
  hgvsp: ENST00000321105.5:c.186A>G(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.186A>G
  hgvsp: ENST00000585031.1:c.186A>G(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.220A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.186A>G
  hgvsp: ENST00000582981.1:c.186A>G(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1970A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.378A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: 5_prime_UTR_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-26A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.182A>G
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 423
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2110
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 35
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15781
  bin: 1.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6143
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 72
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11561
  bin: 2.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 62
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 154
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1585
  bin: 3.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 78
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4412
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 32
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Glu62Glu
num of homozygotes: 0
population: East Asian
population: European (Non-Finnish)
population: South Asian
population: European (Finnish)
population: African
population: Latino
population: Other
reference allele: T
site quality: VQSLOD
site quality: FS
site quality: MQRankSum
site quality: ClippingRankSum
site quality: ReadPosRankSum
site quality: MQ
site quality: QD
site quality: DP
site quality: InbreedingCoeff
site quality: BaseQRankSum

17-18212274-T-TA
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18212274
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18212275
    reference: chr 17
allele count: 17
allele frequency: 3.87614574307994e-4
allele num: 43858
alternate allele: TA
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.177-20dupT
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.363-20dupT
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.333-20dupT
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.181-20dupT
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.373-20dupT
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.181-20dupT
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.372-20dupT
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-1995dupT
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.106-20dupT
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.215-20dupT
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-31-20dupT
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.181-20dupT
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.181-20dupT
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: intron
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 166
  bin: 4.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 58
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1208
  bin: 1.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 17598
  bin: 7.5e0
  variant carriers: 10
genotype depth: GenotypeDepth
  all individuals: 13588
  bin: 1.25e1
  variant carriers: 8
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 72
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2947
  bin: 2.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 936
  bin: 3.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 93
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3056
  bin: 2.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 17563
  bin: 2.5e0
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 59
  bin: 6.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 75
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
num of homozygotes: 0
population: East Asian
population: European (Non-Finnish)
population: European (Finnish)
population: Latino
population: African
population: South Asian
population: Other
reference allele: T
site quality: MQ
site quality: MQRankSum
site quality: DP
site quality: ClippingRankSum
site quality: InbreedingCoeff
site quality: ReadPosRankSum
site quality: VQSLOD
site quality: FS
site quality: QD
site quality: BaseQRankSum

17-18212279-A-AT
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18212279
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18212280
    reference: chr 17
allele count: 2
allele frequency: 4.780800305971219e-5
allele num: 41834
alternate allele: AT
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.181-25_181-24insA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.181-25_181-24insA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.177-25_177-24insA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.373-25_373-24insA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-2000_181-1999insA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.106-25_106-24insA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.372-25_372-24insA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.181-25_181-24insA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.181-25_181-24insA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.215-25_215-24insA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-31-25_-31-24insA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.333-25_333-24insA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.363-25_363-24insA
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: intron
filter: VQSRTrancheINDEL95.00to96.00
genotype depth: GenotypeDepth
  all individuals: 72
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2612
  bin: 2.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 93
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 163
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17186
  bin: 7.5e0
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 134
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12753
  bin: 1.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 854
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 270
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2698
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19139
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 35
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1261
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
num of homozygotes: 0
population: European (Non-Finnish)
population: Other
population: European (Finnish)
population: African
population: Latino
population: South Asian
population: East Asian
reference allele: A
site quality: InbreedingCoeff
site quality: DP
site quality: ClippingRankSum
site quality: ReadPosRankSum
site quality: MQRankSum
site quality: FS
site quality: QD
site quality: VQSLOD
site quality: BaseQRankSum
site quality: MQ

17-18212291-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18212291
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18212291
    reference: chr 17
allele count: 1
allele frequency: 3.232479958624256e-5
allele num: 30936
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.181-36C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.181-36C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.373-36C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.372-36C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.181-36C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.181-36C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.177-36C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-31-36C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.363-36C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-2011C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.106-36C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.333-36C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.215-36C>T
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: intron
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22632
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 58
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 247
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 93
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 8618
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1608
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 35
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 75
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 133
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17397
  bin: 7.5e0
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 1376
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 72
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2613
  bin: 1.75e1
  variant carriers: 1
genotype quality: GenotypeQuality
num of homozygotes: 0
population: South Asian
population: Latino
population: African
population: East Asian
population: European (Finnish)
population: Other
population: European (Non-Finnish)
reference allele: G
site quality: ClippingRankSum
site quality: InbreedingCoeff
site quality: ReadPosRankSum
site quality: MQ
site quality: FS
site quality: VQSLOD
site quality: BaseQRankSum
site quality: DP
site quality: MQRankSum
site quality: QD

http://identifiers.org/exac.variant/17-18212301-A-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18212301
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18212301
    reference: chr 17
allele count: 22
allele frequency: 8.458935712088588e-4
allele num: 26008
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.333-46T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.372-46T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.181-46T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.177-46T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.181-46T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.181-2021T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.106-46T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.215-46T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.373-46T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.363-46T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-31-46T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.181-46T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.181-46T>G
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: intron
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 3041
  bin: 1.75e1
  variant carriers: 5
genotype depth: GenotypeDepth
  all individuals: 133
  bin: 4.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 18967
  bin: 7.5e0
  variant carriers: 11
genotype depth: GenotypeDepth
  all individuals: 75
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 403
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 93
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6253
  bin: 1.25e1
  variant carriers: 9
genotype depth: GenotypeDepth
  all individuals: 912
  bin: 2.75e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 58
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 22780
  bin: 2.5e0
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 1568
  bin: 2.25e1
  variant carriers: 5
genotype depth: GenotypeDepth
  all individuals: 160
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 31
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 19
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 57
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
num of homozygotes: 0
population: Other
population: European (Non-Finnish)
population: Latino
population: East Asian
population: African
population: European (Finnish)
population: South Asian
reference allele: A
site quality: InbreedingCoeff
site quality: ClippingRankSum
site quality: MQRankSum
site quality: MQ
site quality: VQSLOD
site quality: BaseQRankSum
site quality: FS
site quality: ReadPosRankSum
site quality: QD
site quality: DP

17-18217872-C-CT
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18217872
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18217873
    reference: chr 17
allele count: 2
allele frequency: 1.702214581170102e-5
allele num: 117494
alternate allele: CT
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.362+40dupA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-32+40dupA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.332+40dupA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.105+40dupA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.176+40dupA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.180+40dupA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.214+40dupA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.180+40dupA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.371+40dupA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.372+40dupA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.180+40dupA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.180+40dupA
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.180+40dupA
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: intron
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 1653
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3090
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1526
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 306
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 222
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 24
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 516
  bin: 4.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 27890
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 57
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 128
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10229
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 12919
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 166
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
num of homozygotes: 0
population: European (Non-Finnish)
population: Latino
population: European (Finnish)
population: Other
population: African
population: South Asian
population: East Asian
reference allele: C
site quality: MQRankSum
site quality: FS
site quality: InbreedingCoeff
site quality: DP
site quality: VQSLOD
site quality: QD
site quality: BaseQRankSum
site quality: MQ
site quality: ReadPosRankSum
site quality: ClippingRankSum

17-18217876-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18217876
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18217876
    reference: chr 17
allele count: 2
allele frequency: 1.700564587443031e-5
allele num: 117608
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.362+37G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-32+37G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.332+37G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.180+37G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.180+37G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.371+37G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.180+37G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.105+37G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.372+37G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.176+37G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.180+37G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.214+37G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.180+37G>A
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: intron
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 512
  bin: 4.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 1536
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 167
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2903
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 188
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 24
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 78
  bin: 6.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 10244
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13466
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27995
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1377
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
num of homozygotes: 0
population: Other
population: African
population: European (Non-Finnish)
population: Latino
population: European (Finnish)
population: East Asian
population: South Asian
reference allele: C
site quality: VQSLOD
site quality: InbreedingCoeff
site quality: FS
site quality: BaseQRankSum
site quality: MQ
site quality: ClippingRankSum
site quality: MQRankSum
site quality: ReadPosRankSum
site quality: DP
site quality: QD

http://identifiers.org/exac.variant/17-18217880-A-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18217880
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18217880
    reference: chr 17
allele count: 1
allele frequency: 8.493578854386084e-6
allele num: 117736
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.176+33T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.180+33T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.180+33T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.371+33T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.105+33T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-32+33T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.332+33T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.180+33T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.180+33T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.372+33T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.362+33T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.180+33T>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.214+33T>G
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: intron
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 510
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13965
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1062
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2636
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1531
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 156
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 77
  bin: 6.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 10243
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 165
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 57
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 128
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1617
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 24
  bin: 9.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
num of homozygotes: 0
population: Other
population: European (Finnish)
population: East Asian
population: African
population: Latino
population: South Asian
population: European (Non-Finnish)
reference allele: A
site quality: FS
site quality: InbreedingCoeff
site quality: DP
site quality: ReadPosRankSum
site quality: ClippingRankSum
site quality: MQRankSum
site quality: QD
site quality: VQSLOD
site quality: BaseQRankSum
site quality: MQ

17-18219370-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18219370
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18219370
    reference: chr 17
allele count: 3
allele frequency: 2.474267616785431e-5
allele num: 121248
alternate allele: T
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000176994
  ensembl protein: ENSP00000385025
  ensembl transcript: ENST00000406438
  gene symbol: SMCR8
  hgvsc: ENST00000406438.3:c.267C>T
  hgvsp: ENST00000406438.3:c.267C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/17921
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 375
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 71
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 205
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1158
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6780
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6295
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6347
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 186
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7580
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 5300
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 898
  bin: 9.75e1
  variant carriers: 3
genotype depth: GenotypeDepth
  all individuals: 2660
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7723
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 611
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1861
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3939
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 7425
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 463
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 825
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 77
  bin: 3.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 84
  bin: 3.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 44
  bin: 4.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 141
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 31
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2407
  bin: 8.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 1.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 15
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 7
  bin: 7.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 8
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3095
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 67
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 1
  bin: 2.5e0
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 2801
  bin: 7.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3452
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 3416
  bin: 8.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 10163
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 4251
  bin: 6.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 40
  bin: 5.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
  all individuals: 30598
  bin: 9.75e1
  variant carriers: 3
hgvs: p.Tyr89Tyr
num of homozygotes: 0
population: South Asian
  type: Population
  allele count: 0
  allele frequency: 0.0e0
  allele num: 16502
  num of homozygotes: 0
population: Latino
  type: Population
  allele count: 3
  allele frequency: 2.592016588906169e-4
  allele num: 11574
  num of homozygotes: 0
population: Other
population: European (Finnish)
population: African
population: East Asian
population: European (Non-Finnish)
reference allele: C
site quality: MQRankSum
site quality: BaseQRankSum
site quality: VQSLOD
site quality: InbreedingCoeff
site quality: QD
site quality: ClippingRankSum
site quality: MQ
site quality: FS
site quality: ReadPosRankSum
site quality: DP

17-18217881-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18217881
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18217881
    reference: chr 17
allele count: 8
allele frequency: 6.790595025889144e-5
allele num: 117810
alternate allele: A
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.180+32C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.362+32C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-32+32C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.372+32C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.105+32C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.180+32C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.176+32C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.180+32C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.371+32C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.332+32C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.180+32C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.214+32C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.180+32C>T
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: intron
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14042
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 75
  bin: 6.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 126
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28143
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 35
  bin: 7.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 1611
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 305
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1531
  bin: 3.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 2602
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1026
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 508
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 153
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 24
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10241
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 61
  bin: 6.75e1
  variant carriers: 4
genotype quality: GenotypeQuality
num of homozygotes: 0
population: European (Finnish)
population: South Asian
population: Latino
population: East Asian
population: Other
population: African
population: European (Non-Finnish)
reference allele: G
site quality: VQSLOD
site quality: DP
site quality: MQ
site quality: QD
site quality: ClippingRankSum
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: FS
site quality: ReadPosRankSum
site quality: BaseQRankSum

17-18217886-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18217886
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18217886
    reference: chr 17
allele count: 1
allele frequency: 8.469982382436644e-6
allele num: 118064
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.105+27C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.332+27C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.214+27C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.180+27C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.180+27C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.362+27C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-32+27C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.180+27C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.180+27C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.176+27C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.371+27C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.372+27C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.180+27C>T
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: intron
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 28333
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 305
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 24
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 126
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1533
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 163
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 508
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 124
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10274
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 14499
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 2230
  bin: 1.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 1510
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 855
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
num of homozygotes: 0
population: African
population: East Asian
population: South Asian
population: European (Non-Finnish)
population: Latino
population: Other
population: European (Finnish)
reference allele: G
site quality: VQSLOD
site quality: ReadPosRankSum
site quality: DP
site quality: BaseQRankSum
site quality: MQ
site quality: QD
site quality: FS
site quality: InbreedingCoeff
site quality: ClippingRankSum
site quality: MQRankSum

17-18217895-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18217895
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18217895
    reference: chr 17
allele count: 6
allele frequency: 5.05876599834747e-5
allele num: 118606
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.362+18G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.180+18G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.372+18G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.332+18G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.105+18G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.214+18G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.180+18G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.371+18G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.180+18G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.180+18G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.176+18G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-32+18G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.180+18G>A
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: intron
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 163
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 540
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15388
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1250
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 24
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28724
  bin: 2.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 10314
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 305
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 127
  bin: 5.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 1534
  bin: 3.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 76
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 57
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 507
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1529
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
num of homozygotes: 0
population: Latino
population: European (Non-Finnish)
population: South Asian
population: African
population: European (Finnish)
population: East Asian
population: Other
reference allele: C
site quality: InbreedingCoeff
site quality: VQSLOD
site quality: MQRankSum
site quality: ClippingRankSum
site quality: QD
site quality: DP
site quality: FS
site quality: MQ
site quality: ReadPosRankSum
site quality: BaseQRankSum

17-18217896-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18217896
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18217896
    reference: chr 17
allele count: 1
allele frequency: 8.42034355001684e-6
allele num: 118760
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.180+17C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.372+17C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.180+17C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.180+17C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.332+17C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.214+17C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.176+17C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.371+17C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-32+17C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.180+17C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.180+17C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.105+17C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.362+17C>T
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: intron
filter: VQSRTrancheSNP99.60to99.80
genotype depth: GenotypeDepth
  all individuals: 126
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 57
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1442
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 305
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28751
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1218
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 162
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1528
  bin: 3.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 73
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15515
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 518
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10312
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 74
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 510
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
num of homozygotes: 0
population: European (Non-Finnish)
population: South Asian
population: Latino
population: East Asian
population: African
population: European (Finnish)
population: Other
reference allele: G
site quality: QD
site quality: VQSLOD
site quality: ReadPosRankSum
site quality: MQ
site quality: MQRankSum
site quality: FS
site quality: InbreedingCoeff
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: DP

17-18217896-G-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18217896
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18217896
    reference: chr 17
allele count: 1
allele frequency: 8.42034355001684e-6
allele num: 118760
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.105+17C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.362+17C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.176+17C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.372+17C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.180+17C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.371+17C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.180+17C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.214+17C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.332+17C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.180+17C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-32+17C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.180+17C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.180+17C>G
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: intron
filter: VQSRTrancheSNP99.60to99.80
genotype depth: GenotypeDepth
  all individuals: 74
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1218
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 518
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1528
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15515
  bin: 2.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 57
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 73
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1442
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 510
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 305
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10312
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 28751
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
num of homozygotes: 0
population: European (Non-Finnish)
population: African
population: East Asian
population: South Asian
population: Latino
population: European (Finnish)
population: Other
reference allele: G
site quality: BaseQRankSum
site quality: FS
site quality: QD
site quality: InbreedingCoeff
site quality: VQSLOD
site quality: MQRankSum
site quality: ReadPosRankSum
site quality: DP
site quality: ClippingRankSum
site quality: MQ

17-18217896-G-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18217896
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18217896
    reference: chr 17
allele count: 2
allele frequency: 1.684068710003368e-5
allele num: 118760
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.371+17C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.176+17C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.180+17C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.180+17C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.372+17C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-32+17C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.105+17C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.180+17C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.214+17C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.180+17C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.332+17C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.362+17C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.180+17C>A
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: intron
filter: VQSRTrancheSNP99.60to99.80
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10312
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 57
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 73
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 510
  bin: 4.25e1
  variant carriers: 2
genotype depth: GenotypeDepth
  all individuals: 28751
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 126
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1218
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 6
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 162
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 24
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1442
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 305
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 13
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 7.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
num of homozygotes: 0
population: European (Finnish)
population: European (Non-Finnish)
population: East Asian
population: Latino
population: African
population: South Asian
population: Other
reference allele: G
site quality: BaseQRankSum
site quality: QD
site quality: VQSLOD
site quality: FS
site quality: ReadPosRankSum
site quality: InbreedingCoeff
site quality: ClippingRankSum
site quality: MQRankSum
site quality: MQ
site quality: DP

17-18217903-G-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18217903
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18217903
    reference: chr 17
allele count: 648
allele frequency: 5.433051060618764e-3
allele num: 119270
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.214+10C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.180+10C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.180+10C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-32+10C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.180+10C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.180+10C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.176+10C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.105+10C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.332+10C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.362+10C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: NMD_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.180+10C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.372+10C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.371+10C>G
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: intron
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 277
  bin: 4.75e1
  variant carriers: 45
genotype depth: GenotypeDepth
  all individuals: 62
  bin: 9.75e1
  variant carriers: 47
genotype depth: GenotypeDepth
  all individuals: 146
  bin: 5.75e1
  variant carriers: 63
genotype depth: GenotypeDepth
  all individuals: 54
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 48
  bin: 7.75e1
  variant carriers: 30
genotype depth: GenotypeDepth
  all individuals: 487
  bin: 4.25e1
  variant carriers: 50
genotype depth: GenotypeDepth
  all individuals: 978
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 24
  bin: 9.25e1
  variant carriers: 20
genotype depth: GenotypeDepth
  all individuals: 446
  bin: 1.75e1
  variant carriers: 10
genotype depth: GenotypeDepth
  all individuals: 60
  bin: 7.25e1
  variant carriers: 44
genotype depth: GenotypeDepth
  all individuals: 1475
  bin: 3.75e1
  variant carriers: 37
genotype depth: GenotypeDepth
  all individuals: 15843
  bin: 2.25e1
  variant carriers: 22
genotype depth: GenotypeDepth
  all individuals: 1049
  bin: 1.25e1
  variant carriers: 7
genotype depth: GenotypeDepth
  all individuals: 29009
  bin: 2.75e1
  variant carriers: 25
genotype depth: GenotypeDepth
  all individuals: 98
  bin: 6.25e1
  variant carriers: 58
genotype depth: GenotypeDepth
  all individuals: 85
  bin: 6.75e1
  variant carriers: 51
genotype quality: GenotypeQuality
num of homozygotes: 2
population: Latino
population: European (Non-Finnish)
population: Other
population: South Asian
population: African
population: East Asian
population: European (Finnish)
reference allele: G
site quality: VQSLOD
site quality: ClippingRankSum
site quality: MQRankSum
site quality: QD
site quality: InbreedingCoeff
site quality: BaseQRankSum
site quality: FS
site quality: MQ
site quality: DP
site quality: ReadPosRankSum

17-18217905-T-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18217905
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18217905
    reference: chr 17
allele count: 1
allele frequency: 8.373526259378349e-6
allele num: 119424
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.332+8A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.105+8A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.180+8A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.180+8A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-32+8A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.214+8A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.372+8A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.180+8A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: splice_region_variant
  consequence: intron_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.180+8A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.362+8A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.176+8A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.180+8A>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: splice_region_variant
  consequence: intron_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.371+8A>G
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: splice region
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 112
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 414
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 39
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 925
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 949
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 437
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1460
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 84
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29381
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: c.180+8A>G
num of homozygotes: 0
population: European (Non-Finnish)
population: Latino
population: South Asian
population: European (Finnish)
population: African
population: Other
population: East Asian
reference allele: T
site quality: QD
site quality: MQ
site quality: ClippingRankSum
site quality: DP
site quality: InbreedingCoeff
site quality: FS
site quality: BaseQRankSum
site quality: MQRankSum
site quality: ReadPosRankSum
site quality: VQSLOD

17-18217924-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18217924
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18217924
    reference: chr 17
allele count: 1
allele frequency: 8.320990530712775e-6
allele num: 120178
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.94C>T
  hgvsp: ENSP00000462790.1:p.Arg32Cys
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: 5_prime_UTR_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-43C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.169C>T
  hgvsp: ENSP00000464493.1:p.Arg57Cys
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.169C>T
  hgvsp: ENSP00000464338.1:p.Arg57Cys
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.360C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.361C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.165C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.169C>T
  hgvsp: ENSP00000462136.1:p.Arg57Cys
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.169C>T
  hgvsp: ENSP00000462378.1:p.Arg57Cys
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.321C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.169C>T
  hgvsp: ENSP00000321636.5:p.Arg57Cys
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.351C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.203C>T
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 219
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 423
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 202
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1452
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 30061
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 110
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 577
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10485
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 11
  bin: 8.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 480
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16445
  bin: 2.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Arg57Cys
num of homozygotes: 0
population: South Asian
population: East Asian
population: Latino
population: Other
population: African
population: European (Non-Finnish)
population: European (Finnish)
reference allele: G
site quality: BaseQRankSum
site quality: VQSLOD
site quality: MQRankSum
site quality: FS
site quality: InbreedingCoeff
site quality: ReadPosRankSum
site quality: ClippingRankSum
site quality: DP
site quality: MQ
site quality: QD

17-18217924-G-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18217924
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18217924
    reference: chr 17
allele count: 1
allele frequency: 8.320990530712775e-6
allele num: 120178
alternate allele: T
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.169C>A
  hgvsp: ENSP00000321636.5:p.Arg57Ser
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.203C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.321C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.94C>A
  hgvsp: ENSP00000462790.1:p.Arg32Ser
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.169C>A
  hgvsp: ENSP00000464338.1:p.Arg57Ser
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.165C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.169C>A
  hgvsp: ENSP00000464493.1:p.Arg57Ser
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.351C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: 5_prime_UTR_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-43C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.169C>A
  hgvsp: ENSP00000462378.1:p.Arg57Ser
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.169C>A
  hgvsp: ENSP00000462136.1:p.Arg57Ser
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.361C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.360C>A
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 577
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 29
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1452
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 30061
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 219
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 39
  bin: 6.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 423
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 84
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16445
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 480
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10485
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 202
  bin: 1.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Arg57Ser
num of homozygotes: 0
population: African
population: Latino
population: South Asian
population: European (Non-Finnish)
population: European (Finnish)
population: East Asian
population: Other
reference allele: G
site quality: InbreedingCoeff
site quality: FS
site quality: DP
site quality: VQSLOD
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: MQ
site quality: MQRankSum
site quality: ReadPosRankSum
site quality: QD

http://identifiers.org/exac.variant/17-18217926-C-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18217926
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18217926
    reference: chr 17
allele count: 1
allele frequency: 8.315593400745077e-6
allele num: 120256
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.167G>T
  hgvsp: ENSP00000464493.1:p.Gly56Val
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.167G>T
  hgvsp: ENSP00000464338.1:p.Gly56Val
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.359G>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.358G>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.92G>T
  hgvsp: ENSP00000462790.1:p.Gly31Val
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.167G>T
  hgvsp: ENSP00000462378.1:p.Gly56Val
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: 5_prime_UTR_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-45G>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.349G>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.201G>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.319G>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.167G>T
  hgvsp: ENSP00000462136.1:p.Gly56Val
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.167G>T
  hgvsp: ENSP00000321636.5:p.Gly56Val
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.163G>T
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 16
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10486
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 39
  bin: 6.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 187
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 219
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 539
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16486
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 451
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 83
  bin: 5.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Gly56Val
num of homozygotes: 0
population: African
population: South Asian
population: European (Non-Finnish)
population: East Asian
population: Other
population: Latino
population: European (Finnish)
reference allele: C
site quality: MQRankSum
site quality: DP
site quality: QD
site quality: InbreedingCoeff
site quality: FS
site quality: MQ
site quality: VQSLOD
site quality: ReadPosRankSum
site quality: ClippingRankSum
site quality: BaseQRankSum

17-18217926-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18217926
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18217926
    reference: chr 17
allele count: 1
allele frequency: 8.315593400745077e-6
allele num: 120256
alternate allele: T
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.167G>A
  hgvsp: ENSP00000321636.5:p.Gly56Asp
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.201G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.319G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.167G>A
  hgvsp: ENSP00000464493.1:p.Gly56Asp
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.92G>A
  hgvsp: ENSP00000462790.1:p.Gly31Asp
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.163G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.349G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.359G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.167G>A
  hgvsp: ENSP00000462378.1:p.Gly56Asp
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.167G>A
  hgvsp: ENSP00000462136.1:p.Gly56Asp
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.358G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.167G>A
  hgvsp: ENSP00000464338.1:p.Gly56Asp
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: 5_prime_UTR_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-45G>A
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 110
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10486
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 83
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 219
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16486
  bin: 2.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 27
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 187
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1455
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 539
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 451
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 30103
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 422
  bin: 4.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Gly56Asp
num of homozygotes: 0
population: East Asian
population: European (Finnish)
population: South Asian
population: African
population: Other
population: European (Non-Finnish)
population: Latino
reference allele: C
site quality: FS
site quality: VQSLOD
site quality: QD
site quality: BaseQRankSum
site quality: MQRankSum
site quality: InbreedingCoeff
site quality: DP
site quality: ReadPosRankSum
site quality: MQ
site quality: ClippingRankSum

17-18217928-G-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18217928
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18217928
    reference: chr 17
allele count: 1
allele frequency: 8.312275568559649e-6
allele num: 120304
alternate allele: T
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.347C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.356C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: 5_prime_UTR_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-47C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.165C>A
  hgvsp: ENSP00000464338.1:p.Asn55Lys
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.165C>A
  hgvsp: ENSP00000464493.1:p.Asn55Lys
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.165C>A
  hgvsp: ENSP00000462136.1:p.Asn55Lys
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.161C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.317C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.90C>A
  hgvsp: ENSP00000462790.1:p.Asn30Lys
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.199C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.165C>A
  hgvsp: ENSP00000462378.1:p.Asn55Lys
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.357C>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.165C>A
  hgvsp: ENSP00000321636.5:p.Asn55Lys
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 26
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 83
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 170
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 423
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 38
  bin: 6.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16503
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 1453
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 3
  bin: 8.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 221
  bin: 4.75e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 30130
  bin: 2.75e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Asn55Lys
num of homozygotes: 0
population: African
population: South Asian
population: European (Finnish)
population: East Asian
population: Latino
population: Other
population: European (Non-Finnish)
reference allele: G
site quality: MQ
site quality: ClippingRankSum
site quality: ReadPosRankSum
site quality: BaseQRankSum
site quality: InbreedingCoeff
site quality: QD
site quality: DP
site quality: MQRankSum
site quality: FS
site quality: VQSLOD

17-18217939-G-A
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18217939
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18217939
    reference: chr 17
allele count: 1
allele frequency: 8.316976612661764e-6
allele num: 120236
alternate allele: A
annotation: Annotation
  canonical: false
  consequence: 5_prime_UTR_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-58C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.336C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.79C>T
  hgvsp: ENST00000580095.1:c.79C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.154C>T
  hgvsp: ENST00000585031.1:c.154C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.154C>T
  hgvsp: ENST00000461127.1:c.154C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.150C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.154C>T
  hgvsp: ENST00000584582.1:c.154C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.154C>T
  hgvsp: ENST00000582981.1:c.154C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.346C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.306C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.188C>T
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.154C>T
  hgvsp: ENST00000321105.5:c.154C>T(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.345C>T
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 217
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 258
  bin: 1.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 419
  bin: 4.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 35
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 39
  bin: 6.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 16282
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10
  bin: 8.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10476
  bin: 3.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 25
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 84
  bin: 5.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 556
  bin: 7.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 9.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Leu52Leu
num of homozygotes: 0
population: Latino
population: South Asian
population: East Asian
population: African
population: European (Non-Finnish)
population: European (Finnish)
population: Other
reference allele: G
site quality: ReadPosRankSum
site quality: MQ
site quality: DP
site quality: ClippingRankSum
site quality: BaseQRankSum
site quality: QD
site quality: InbreedingCoeff
site quality: MQRankSum
site quality: FS
site quality: VQSLOD

17-18217944-G-C
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18217944
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18217944
    reference: chr 17
allele count: 1
allele frequency: 8.324176738920521e-6
allele num: 120132
alternate allele: C
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.183C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.149C>G
  hgvsp: ENSP00000462136.1:p.Ala50Gly
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.331C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.149C>G
  hgvsp: ENSP00000462378.1:p.Ala50Gly
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.145C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: true
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.149C>G
  hgvsp: ENSP00000321636.5:p.Ala50Gly
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.74C>G
  hgvsp: ENSP00000462790.1:p.Ala25Gly
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.149C>G
  hgvsp: ENSP00000464338.1:p.Ala50Gly
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: 5_prime_UTR_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-63C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: missense_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.149C>G
  hgvsp: ENSP00000464493.1:p.Ala50Gly
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.341C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.340C>G
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.301C>G
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: missense
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 1447
  bin: 3.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 217
  bin: 4.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 16183
  bin: 2.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 17
  bin: 7.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 109
  bin: 5.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 15
  bin: 9.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 10462
  bin: 3.25e1
  variant carriers: 1
genotype depth: GenotypeDepth
  all individuals: 16
  bin: 7.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 576
  bin: 1.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 30148
  bin: 2.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 24
  bin: 2.5e0
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 34
  bin: 6.75e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 4
  bin: 9.25e1
  variant carriers: 0
genotype depth: GenotypeDepth
  all individuals: 39
  bin: 6.25e1
  variant carriers: 0
genotype quality: GenotypeQuality
hgvs: p.Ala50Gly
num of homozygotes: 0
population: European (Finnish)
population: European (Non-Finnish)
population: African
population: Latino
population: East Asian
population: Other
population: South Asian
reference allele: G
site quality: DP
site quality: InbreedingCoeff
site quality: MQRankSum
site quality: QD
site quality: BaseQRankSum
site quality: ClippingRankSum
site quality: MQ
site quality: VQSLOD
site quality: FS
site quality: ReadPosRankSum

17-18217958-C-T
type: Variant
location: Region
  begin: Position
    type: ExactPosition
    position: 18217958
    reference: chr 17
  end: Position
    type: ExactPosition
    position: 18217958
    reference: chr 17
allele count: 1869
allele frequency: 1.569032388052184e-2
allele num: 119118
alternate allele: T
annotation: Annotation
  canonical: true
  consequence: synonymous_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000321636
  ensembl transcript: ENST00000321105
  gene symbol: TOP3A
  hgvsc: ENST00000321105.5:c.135G>A
  hgvsp: ENST00000321105.5:c.135G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000582230
  gene symbol: TOP3A
  hgvsc: ENST00000582230.1:n.326G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000580713
  gene symbol: TOP3A
  hgvsc: ENST00000580713.1:n.169G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462790
  ensembl transcript: ENST00000580095
  gene symbol: TOP3A
  hgvsc: ENST00000580095.1:c.60G>A
  hgvsp: ENST00000580095.1:c.60G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584669
  gene symbol: TOP3A
  hgvsc: ENST00000584669.1:n.287G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464493
  ensembl transcript: ENST00000585031
  gene symbol: TOP3A
  hgvsc: ENST00000585031.1:c.135G>A
  hgvsp: ENST00000585031.1:c.135G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462136
  ensembl transcript: ENST00000584582
  gene symbol: TOP3A
  hgvsc: ENST00000584582.1:c.135G>A
  hgvsp: ENST00000584582.1:c.135G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: 5_prime_UTR_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000442336
  ensembl transcript: ENST00000542570
  gene symbol: TOP3A
  hgvsc: ENST00000542570.1:c.-77G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000583328
  gene symbol: TOP3A
  hgvsc: ENST00000583328.1:n.131G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000584887
  gene symbol: TOP3A
  hgvsc: ENST00000584887.1:n.327G>A
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000464338
  ensembl transcript: ENST00000461127
  gene symbol: TOP3A
  hgvsc: ENST00000461127.1:c.135G>A
  hgvsp: ENST00000461127.1:c.135G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: synonymous_variant
  consequence: NMD_transcript_variant
  ensembl gene: ENSG00000177302
  ensembl protein: ENSP00000462378
  ensembl transcript: ENST00000582981
  gene symbol: TOP3A
  hgvsc: ENST00000582981.1:c.135G>A
  hgvsp: ENST00000582981.1:c.135G>A(p.%3D)
  variant of: http://identifiers.org/hgnc/11992
annotation: Annotation
  canonical: false
  consequence: non_coding_transcript_variant
  consequence: non_coding_transcript_exon_variant
  ensembl gene: ENSG00000177302
  ensembl transcript: ENST00000472959
  gene symbol: TOP3A
  hgvsc: ENST00000472959.1:n.317G>A
  variant of: http://identifiers.org/hgnc/11992
canonical: true
consequence: synonymous
filter: PASS
genotype depth: GenotypeDepth
  all individuals: 28
  bin: 2.5e0
  variant carriers: 0
hgvs: p.Ala45Ala
num of homozygotes: 94
reference allele: C

GenotypeDepth
all individuals: 184
bin: 4.75e1
variant carriers: 0

GenotypeDepth
all individuals: 4
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 560
bin: 7.5e0
variant carriers: 0

GenotypeQuality
all individuals: 214
bin: 1.75e1
variant carriers: 0

GenotypeQuality
all individuals: 616
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 579
bin: 5.75e1
variant carriers: 0

GenotypeQuality
all individuals: 3592
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 2515
bin: 6.75e1
variant carriers: 0

GenotypeQuality
all individuals: 754
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 1124
bin: 9.75e1
variant carriers: 1

GenotypeQuality
all individuals: 169
bin: 8.75e1
variant carriers: 0

GenotypeQuality
all individuals: 162
bin: 2.5e0
variant carriers: 0

GenotypeQuality
all individuals: 188
bin: 1.25e1
variant carriers: 0

GenotypeQuality
all individuals: 776
bin: 4.75e1
variant carriers: 0

GenotypeQuality
all individuals: 3411
bin: 3.25e1
variant carriers: 0

GenotypeQuality
all individuals: 399
bin: 8.25e1
variant carriers: 0

GenotypeQuality
all individuals: 747
bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 19148
bin: 2.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1526
bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 23389
bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 593
bin: 5.25e1
variant carriers: 0

GenotypeQuality
all individuals: 239
bin: 9.25e1
variant carriers: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 5510
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11378
num of homozygotes: 0

Latino
type: Population
allele count: 1
allele frequency: 1.397819401733296e-4
allele num: 7154
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 5228
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 42352
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 7220
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 638
num of homozygotes: 0

InbreedingCoeff
type: SiteQuality
SIO_000300: -2.4e-3

MQ
type: SiteQuality
SIO_000300: 6.0e1

MQRankSum
type: SiteQuality
SIO_000300: 9.22e-1

BaseQRankSum
type: SiteQuality
SIO_000300: -3.77e-1

FS
type: SiteQuality
SIO_000300: 0.0e0

ClippingRankSum
type: SiteQuality
SIO_000300: 0.0e0

QD
type: SiteQuality
SIO_000300: 2.444e1

ReadPosRankSum
type: SiteQuality
SIO_000300: 6.6e-1

VQSLOD
type: SiteQuality
SIO_000300: -1.845e0

DP
type: SiteQuality
SIO_000300: 9.74349e5

GenotypeDepth
all individuals: 182
bin: 4.75e1
variant carriers: 0

GenotypeDepth
all individuals: 11
bin: 8.75e1
variant carriers: 1

GenotypeQuality
all individuals: 182
bin: 8.75e1
variant carriers: 0

GenotypeQuality
all individuals: 805
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 550
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 16820
bin: 2.25e1
variant carriers: 0

GenotypeQuality
all individuals: 99
bin: 1.25e1
variant carriers: 0

GenotypeQuality
all individuals: 658
bin: 4.75e1
variant carriers: 0

GenotypeQuality
all individuals: 349
bin: 7.5e0
variant carriers: 0

GenotypeQuality
all individuals: 303
bin: 5.75e1
variant carriers: 0

GenotypeQuality
all individuals: 2812
bin: 3.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1340
bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 60
bin: 2.5e0
variant carriers: 0

GenotypeQuality
all individuals: 426
bin: 8.25e1
variant carriers: 0

GenotypeQuality
all individuals: 433
bin: 5.25e1
variant carriers: 0

GenotypeQuality
all individuals: 100
bin: 1.75e1
variant carriers: 0

GenotypeQuality
all individuals: 249
bin: 9.25e1
variant carriers: 1

GenotypeQuality
all individuals: 2785
bin: 6.75e1
variant carriers: 0

GenotypeQuality
all individuals: 799
bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 2898
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 27899
bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1136
bin: 9.75e1
variant carriers: 9

African
type: Population
allele count: 7
allele frequency: 9.114583333333333e-4
allele num: 7680
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 5538
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 12000
num of homozygotes: 0

Latino
type: Population
allele count: 2
allele frequency: 2.526528549772613e-4
allele num: 7916
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 45702
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 674
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 5910
num of homozygotes: 0

QD
type: SiteQuality
SIO_000300: 1.481e1

VQSLOD
type: SiteQuality
SIO_000300: 2.97e0

ReadPosRankSum
type: SiteQuality
SIO_000300: 4.33e-1

ClippingRankSum
type: SiteQuality
SIO_000300: -6.33e-1

DP
type: SiteQuality
SIO_000300: 1.029028e6

MQRankSum
type: SiteQuality
SIO_000300: 5.91e-1

FS
type: SiteQuality
SIO_000300: 0.0e0

InbreedingCoeff
type: SiteQuality
SIO_000300: -1.9e-3

MQ
type: SiteQuality
SIO_000300: 6.0e1

BaseQRankSum
type: SiteQuality
SIO_000300: -1.447e0

GenotypeDepth
all individuals: 4
bin: 9.25e1
variant carriers: 0

GenotypeDepth
all individuals: 129
bin: 5.25e1
variant carriers: 0

GenotypeDepth
all individuals: 55
bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 491
bin: 4.75e1
variant carriers: 0

GenotypeQuality
all individuals: 799
bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 10273
bin: 2.25e1
variant carriers: 0

GenotypeQuality
all individuals: 326
bin: 5.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1491
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 71
bin: 1.75e1
variant carriers: 0

GenotypeQuality
all individuals: 453
bin: 8.25e1
variant carriers: 0

GenotypeQuality
all individuals: 125
bin: 7.5e0
variant carriers: 0

GenotypeQuality
all individuals: 48
bin: 1.25e1
variant carriers: 0

GenotypeQuality
all individuals: 256
bin: 5.75e1
variant carriers: 0

GenotypeQuality
all individuals: 37993
bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 50
bin: 2.5e0
variant carriers: 0

GenotypeQuality
all individuals: 1470
bin: 3.25e1
variant carriers: 0

GenotypeQuality
all individuals: 194
bin: 8.75e1
variant carriers: 0

GenotypeQuality
all individuals: 3162
bin: 6.75e1
variant carriers: 0

GenotypeQuality
all individuals: 1140
bin: 9.75e1
variant carriers: 1

GenotypeQuality
all individuals: 845
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 265
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 866
bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 385
bin: 4.25e1
variant carriers: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8800
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 794
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 1
allele frequency: 1.663893510815308e-4
allele num: 6010
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 13564
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 7222
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 53854
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 9556
num of homozygotes: 0

FS
type: SiteQuality
SIO_000300: 0.0e0

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.47e0

InbreedingCoeff
type: SiteQuality
SIO_000300: 2.1e-3

VQSLOD
type: SiteQuality
SIO_000300: -2.575e0

QD
type: SiteQuality
SIO_000300: 2.297e1

ClippingRankSum
type: SiteQuality
SIO_000300: 4.36e-1

MQ
type: SiteQuality
SIO_000300: 6.0e1

BaseQRankSum
type: SiteQuality
SIO_000300: -2.269e0

MQRankSum
type: SiteQuality
SIO_000300: -7.37e-1

DP
type: SiteQuality
SIO_000300: 1.167982e6

GenotypeDepth
all individuals: 7
bin: 9.75e1
variant carriers: 0

GenotypeDepth
all individuals: 10
bin: 8.75e1
variant carriers: 0

GenotypeDepth
all individuals: 12
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 11
bin: 1.25e1
variant carriers: 0

GenotypeQuality
all individuals: 266
bin: 9.25e1
variant carriers: 0

GenotypeQuality
all individuals: 242
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 337
bin: 5.75e1
variant carriers: 0

GenotypeQuality
all individuals: 460
bin: 8.25e1
variant carriers: 0

GenotypeQuality
all individuals: 302
bin: 4.75e1
variant carriers: 0

GenotypeQuality
all individuals: 32
bin: 1.75e1
variant carriers: 0

GenotypeQuality
all individuals: 840
bin: 3.25e1
variant carriers: 0

GenotypeQuality
all individuals: 51
bin: 7.5e0
variant carriers: 0

GenotypeQuality
all individuals: 43361
bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 491
bin: 3.75e1
variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

African
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allele frequency: 0.0e0
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num of homozygotes: 0

Latino
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allele frequency: 9.523809523809524e-5
allele num: 10500
num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 6286
num of homozygotes: 0

Other
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

European (Non-Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 58662
num of homozygotes: 0

South Asian
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allele frequency: 0.0e0
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num of homozygotes: 0

East Asian
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allele frequency: 0.0e0
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num of homozygotes: 0

ClippingRankSum
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SIO_000300: -1.493e0

FS
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QD
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DP
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MQ
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ReadPosRankSum
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BaseQRankSum
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InbreedingCoeff
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SIO_000300: 7.0e-4

VQSLOD
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MQRankSum
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SIO_000300: 7.32e-1

GenotypeDepth
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variant carriers: 0

GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 6490
num of homozygotes: 0

Other
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allele frequency: 0.0e0
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num of homozygotes: 0

South Asian
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allele frequency: 0.0e0
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num of homozygotes: 0

East Asian
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allele frequency: 8.337303477846593e-4
allele num: 8396
num of homozygotes: 0

Latino
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allele count: 0
allele frequency: 0.0e0
allele num: 11144
num of homozygotes: 0

European (Non-Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 62942
num of homozygotes: 0

African
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

DP
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SIO_000300: 1.319437e6

ClippingRankSum
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SIO_000300: -5.610000000000001e-1

MQRankSum
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QD
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SIO_000300: 1.478e1

MQ
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SIO_000300: 6.0e1

InbreedingCoeff
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SIO_000300: -4.0e-4

BaseQRankSum
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SIO_000300: -2.754e0

FS
type: SiteQuality
SIO_000300: 5.72e-1

VQSLOD
type: SiteQuality
SIO_000300: 9.47e-1

ReadPosRankSum
type: SiteQuality
SIO_000300: 4.78e-1

GenotypeDepth
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variant carriers: 0

GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 9.75e1
variant carriers: 1

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 6544
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11322
num of homozygotes: 0

European (Non-Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 64404
num of homozygotes: 0

East Asian
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allele frequency: 0.0e0
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African
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allele frequency: 0.0e0
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num of homozygotes: 0

Other
type: Population
allele count: 0
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num of homozygotes: 0

South Asian
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allele count: 1
allele frequency: 6.338742393509128e-5
allele num: 15776
num of homozygotes: 0

MQ
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SIO_000300: 5.873e1

ReadPosRankSum
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SIO_000300: 1.59e0

QD
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InbreedingCoeff
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DP
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MQRankSum
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BaseQRankSum
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FS
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ClippingRankSum
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SIO_000300: -1.441e0

VQSLOD
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SIO_000300: -1.988e0

GenotypeDepth
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variant carriers: 0

GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 892
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6550
num of homozygotes: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
allele num: 8540
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10156
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.547604308530395e-5
allele num: 64616
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11364
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 15854
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VQSLOD
type: SiteQuality
SIO_000300: -4.933e-1

MQ
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SIO_000300: 6.0e1

FS
type: SiteQuality
SIO_000300: 0.0e0

DP
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SIO_000300: 1.353593e6

MQRankSum
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SIO_000300: -9.62e-1

QD
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BaseQRankSum
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SIO_000300: 1.37e0

ClippingRankSum
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SIO_000300: -1.662e0

InbreedingCoeff
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SIO_000300: -2.0e-4

ReadPosRankSum
type: SiteQuality
SIO_000300: 1.25e0

GenotypeDepth
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variant carriers: 0

GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

South Asian
type: Population
allele count: 1
allele frequency: 6.167509559639817e-5
allele num: 16214
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6582
num of homozygotes: 0

European (Non-Finnish)
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allele count: 5
allele frequency: 7.588865616367666e-5
allele num: 65886
num of homozygotes: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
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African
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allele count: 0
allele frequency: 0.0e0
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Other
type: Population
allele count: 0
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allele num: 900
num of homozygotes: 0

Latino
type: Population
allele count: 1
allele frequency: 8.719916288803627e-5
allele num: 11468
num of homozygotes: 0

DP
type: SiteQuality
SIO_000300: 1.377303e6

MQRankSum
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SIO_000300: 2.04e-1

BaseQRankSum
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QD
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ClippingRankSum
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ReadPosRankSum
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InbreedingCoeff
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FS
type: SiteQuality
SIO_000300: 5.47e-1

VQSLOD
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MQ
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SIO_000300: 5.863e1

GenotypeDepth
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variant carriers: 1

GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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East Asian
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

African
type: Population
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Latino
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allele frequency: 8.686587908269631e-5
allele num: 11512
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Other
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European (Finnish)
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allele count: 1
allele frequency: 1.514692517418964e-4
allele num: 6602
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European (Non-Finnish)
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allele count: 5
allele frequency: 7.546941979110065e-5
allele num: 66252
num of homozygotes: 0

South Asian
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DP
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MQ
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FS
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MQRankSum
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BaseQRankSum
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ReadPosRankSum
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InbreedingCoeff
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VQSLOD
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ClippingRankSum
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QD
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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European (Finnish)
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allele count: 0
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num of homozygotes: 0

East Asian
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African
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South Asian
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Latino
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allele frequency: 1.73550850399167e-4
allele num: 11524
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European (Non-Finnish)
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allele frequency: 0.0e0
allele num: 66354
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Other
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ReadPosRankSum
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MQRankSum
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QD
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ClippingRankSum
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FS
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BaseQRankSum
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DP
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MQ
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InbreedingCoeff
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VQSLOD
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

European (Finnish)
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allele frequency: 0.0e0
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num of homozygotes: 0

Latino
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allele frequency: 0.0e0
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num of homozygotes: 0

East Asian
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allele frequency: 0.0e0
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Other
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European (Non-Finnish)
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num of homozygotes: 0

African
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South Asian
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BaseQRankSum
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SIO_000300: -1.87e-1

ClippingRankSum
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ReadPosRankSum
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InbreedingCoeff
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FS
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VQSLOD
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MQ
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MQRankSum
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DP
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QD
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 2.25e1
variant carriers: 0

European (Non-Finnish)
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allele frequency: 1.507204437209863e-5
allele num: 66348
num of homozygotes: 0

East Asian
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Latino
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allele num: 11524
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South Asian
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African
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Other
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allele frequency: 0.0e0
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European (Finnish)
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allele frequency: 0.0e0
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VQSLOD
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MQRankSum
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BaseQRankSum
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DP
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FS
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ClippingRankSum
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MQ
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QD
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InbreedingCoeff
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ReadPosRankSum
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

East Asian
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allele frequency: 9.269988412514484e-4
allele num: 8630
num of homozygotes: 0

European (Non-Finnish)
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Other
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European (Finnish)
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South Asian
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African
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Latino
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MQ
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SIO_000300: 5.868e1

DP
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VQSLOD
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InbreedingCoeff
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ClippingRankSum
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QD
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BaseQRankSum
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MQRankSum
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ReadPosRankSum
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FS
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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Other
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East Asian
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African
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Latino
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European (Non-Finnish)
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South Asian
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allele num: 16300
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European (Finnish)
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allele frequency: 0.0e0
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FS
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MQRankSum
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VQSLOD
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BaseQRankSum
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MQ
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ClippingRankSum
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InbreedingCoeff
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DP
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QD
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ReadPosRankSum
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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Latino
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allele frequency: 0.0e0
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num of homozygotes: 0

South Asian
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allele frequency: 6.147792942333702e-5
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African
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East Asian
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European (Non-Finnish)
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Other
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European (Finnish)
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MQ
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FS
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MQRankSum
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InbreedingCoeff
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QD
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BaseQRankSum
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ClippingRankSum
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DP
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ReadPosRankSum
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VQSLOD
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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Latino
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allele num: 11448
num of homozygotes: 0

Other
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European (Non-Finnish)
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African
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South Asian
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European (Finnish)
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East Asian
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QD
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ClippingRankSum
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MQRankSum
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DP
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BaseQRankSum
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FS
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VQSLOD
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MQ
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InbreedingCoeff
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ReadPosRankSum
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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South Asian
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African
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European (Non-Finnish)
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Latino
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East Asian
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Other
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European (Finnish)
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FS
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MQRankSum
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InbreedingCoeff
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ReadPosRankSum
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MQ
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VQSLOD
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DP
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BaseQRankSum
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ClippingRankSum
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QD
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

African
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allele count: 1
allele frequency: 9.775171065493646e-5
allele num: 10230
num of homozygotes: 0

South Asian
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allele count: 0
allele frequency: 0.0e0
allele num: 16080
num of homozygotes: 0

Latino
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allele count: 2
allele frequency: 1.75284837861525e-4
allele num: 11410
num of homozygotes: 0

Other
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allele frequency: 0.0e0
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num of homozygotes: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

European (Finnish)
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allele count: 1
allele frequency: 1.529987760097919e-4
allele num: 6536
num of homozygotes: 0

European (Non-Finnish)
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allele count: 21
allele frequency: 3.231166912850812e-4
allele num: 64992
num of homozygotes: 0

ReadPosRankSum
type: SiteQuality
SIO_000300: 3.32e-1

BaseQRankSum
type: SiteQuality
SIO_000300: 2.12e0

ClippingRankSum
type: SiteQuality
SIO_000300: -2.53e-1

InbreedingCoeff
type: SiteQuality
SIO_000300: -5.0e-4

FS
type: SiteQuality
SIO_000300: 6.4e-1

MQ
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SIO_000300: 5.855e1

MQRankSum
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SIO_000300: 4.13e-1

QD
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DP
type: SiteQuality
SIO_000300: 1.347871e6

VQSLOD
type: SiteQuality
SIO_000300: 9.63e-1

GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

African
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allele count: 0
allele frequency: 0.0e0
allele num: 10232
num of homozygotes: 0

Other
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

South Asian
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
allele num: 8538
num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 6536
num of homozygotes: 0

Latino
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allele count: 0
allele frequency: 0.0e0
allele num: 11412
num of homozygotes: 0

European (Non-Finnish)
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allele count: 1
allele frequency: 1.538698261270965e-5
allele num: 64990
num of homozygotes: 0

ReadPosRankSum
type: SiteQuality
SIO_000300: 3.42e-1

VQSLOD
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SIO_000300: 2.03e-1

QD
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ClippingRankSum
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InbreedingCoeff
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SIO_000300: -3.0e-4

BaseQRankSum
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SIO_000300: 1.7e0

MQRankSum
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MQ
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SIO_000300: 5.863e1

FS
type: SiteQuality
SIO_000300: 0.0e0

DP
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SIO_000300: 1.347347e6

GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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Latino
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allele count: 0
allele frequency: 0.0e0
allele num: 11366
num of homozygotes: 0

European (Non-Finnish)
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allele count: 1
allele frequency: 1.548035542896065e-5
allele num: 64598
num of homozygotes: 0

African
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allele frequency: 0.0e0
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num of homozygotes: 0

East Asian
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allele frequency: 0.0e0
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Other
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South Asian
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

European (Finnish)
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allele count: 3
allele frequency: 4.609711124769514e-4
allele num: 6508
num of homozygotes: 0

QD
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SIO_000300: 1.286e1

ReadPosRankSum
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SIO_000300: -2.0e-2

MQ
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FS
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MQRankSum
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InbreedingCoeff
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ClippingRankSum
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SIO_000300: 1.92e-1

VQSLOD
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SIO_000300: -2.476e-1

BaseQRankSum
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SIO_000300: 4.38e-1

DP
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SIO_000300: 1.334493e6

GenotypeDepth
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variant carriers: 0

GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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European (Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 6496
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
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Latino
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

East Asian
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allele count: 1
allele frequency: 1.178967224711153e-4
allele num: 8482
num of homozygotes: 0

European (Non-Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 64354
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South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
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African
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allele frequency: 0.0e0
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ClippingRankSum
type: SiteQuality
SIO_000300: 1.67e0

FS
type: SiteQuality
SIO_000300: 1.0014e1

VQSLOD
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MQRankSum
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QD
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DP
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InbreedingCoeff
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MQ
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SIO_000300: 5.781e1

BaseQRankSum
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SIO_000300: 1.09e0

ReadPosRankSum
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SIO_000300: 9.77e-1

GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 1

Other
type: Population
allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

European (Non-Finnish)
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allele count: 1
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allele num: 61778
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European (Finnish)
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Latino
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African
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East Asian
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South Asian
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MQRankSum
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QD
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VQSLOD
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BaseQRankSum
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ClippingRankSum
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InbreedingCoeff
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MQ
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FS
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DP
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ReadPosRankSum
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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Other
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num of homozygotes: 0

East Asian
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Latino
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allele frequency: 0.0e0
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num of homozygotes: 0

South Asian
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African
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allele frequency: 0.0e0
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European (Finnish)
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allele count: 0
allele frequency: 0.0e0
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European (Non-Finnish)
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allele count: 1
allele frequency: 1.626651050816579e-5
allele num: 61476
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InbreedingCoeff
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MQRankSum
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FS
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ReadPosRankSum
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MQ
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DP
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VQSLOD
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QD
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BaseQRankSum
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ClippingRankSum
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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African
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Latino
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East Asian
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European (Non-Finnish)
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allele num: 60492
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South Asian
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European (Finnish)
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Other
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DP
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ClippingRankSum
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InbreedingCoeff
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MQ
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VQSLOD
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MQRankSum
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ReadPosRankSum
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FS
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QD
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BaseQRankSum
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 1.75e1
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 8.75e1
variant carriers: 0

African
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allele count: 0
allele frequency: 0.0e0
allele num: 6536
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 12762
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 648
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 9436
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 4786
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 2.352387673488591e-5
allele num: 42510
num of homozygotes: 0

ReadPosRankSum
type: SiteQuality
SIO_000300: -5.600000000000001e-1

MQRankSum
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InbreedingCoeff
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QD
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MQ
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FS
type: SiteQuality
SIO_000300: 0.0e0

VQSLOD
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SIO_000300: 1.81e-1

DP
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SIO_000300: 9.10839e5

BaseQRankSum
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SIO_000300: 2.67e0

ClippingRankSum
type: SiteQuality
SIO_000300: 5.600000000000001e-1

GenotypeDepth
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variant carriers: 0

GenotypeDepth
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variant carriers: 0

GenotypeDepth
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variant carriers: 0

GenotypeDepth
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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bin: 7.75e1
variant carriers: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6536
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 12782
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 9450
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 42594
num of homozygotes: 0

East Asian
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allele count: 1
allele frequency: 1.633986928104575e-4
allele num: 6120
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 4784
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

MQ
type: SiteQuality
SIO_000300: 5.553e1

VQSLOD
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MQRankSum
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BaseQRankSum
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DP
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SIO_000300: 9.15063e5

FS
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SIO_000300: 6.41e0

ReadPosRankSum
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SIO_000300: -1.591e0

ClippingRankSum
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SIO_000300: 1.36e0

QD
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InbreedingCoeff
type: SiteQuality
SIO_000300: -6.1e-3

GenotypeDepth
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variant carriers: 0

GenotypeDepth
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variant carriers: 1

GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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variant carriers: 1

GenotypeQuality
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variant carriers: 0

GenotypeQuality
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bin: 9.25e1
variant carriers: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 4782
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 652
num of homozygotes: 0

South Asian
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allele count: 1
allele frequency: 7.855459544383346e-5
allele num: 12730
num of homozygotes: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
allele num: 6090
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6526
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 9418
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 42438
num of homozygotes: 0

VQSLOD
type: SiteQuality
SIO_000300: 5.0e-1

ClippingRankSum
type: SiteQuality
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MQRankSum
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SIO_000300: -8.3e-1

MQ
type: SiteQuality
SIO_000300: 6.0e1

InbreedingCoeff
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SIO_000300: -6.8e-3

DP
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SIO_000300: 9.28825e5

BaseQRankSum
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SIO_000300: -2.137e0

FS
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SIO_000300: 0.0e0

ReadPosRankSum
type: SiteQuality
SIO_000300: 6.66e-1

QD
type: SiteQuality
SIO_000300: 1.289e1

GenotypeDepth
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variant carriers: 0

GenotypeDepth
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variant carriers: 0

GenotypeDepth
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variant carriers: 0

GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 9.25e1
variant carriers: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 652
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6536
num of homozygotes: 0

East Asian
type: Population
allele count: 1
allele frequency: 1.632919660352711e-4
allele num: 6124
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 12784
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 42702
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 9444
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

FS
type: SiteQuality
SIO_000300: 4.218e0

VQSLOD
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SIO_000300: -4.727e-1

ReadPosRankSum
type: SiteQuality
SIO_000300: -6.97e-1

MQ
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SIO_000300: 6.0e1

InbreedingCoeff
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SIO_000300: -6.4e-3

BaseQRankSum
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DP
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SIO_000300: 9.34953e5

QD
type: SiteQuality
SIO_000300: 7.54e0

MQRankSum
type: SiteQuality
SIO_000300: -4.44e-1

ClippingRankSum
type: SiteQuality
SIO_000300: 6.13e-1

GenotypeDepth
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variant carriers: 0

GenotypeDepth
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variant carriers: 0

GenotypeDepth
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variant carriers: 0

GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 3

GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 4.75e1
variant carriers: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 656
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 9522
num of homozygotes: 0

South Asian
type: Population
allele count: 3
allele frequency: 2.332814930015552e-4
allele num: 12860
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 4800
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 43004
num of homozygotes: 0

ClippingRankSum
type: SiteQuality
SIO_000300: 3.32e-1

InbreedingCoeff
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DP
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QD
type: SiteQuality
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FS
type: SiteQuality
SIO_000300: 1.733e0

VQSLOD
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ReadPosRankSum
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MQRankSum
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MQ
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SIO_000300: 6.0e1

BaseQRankSum
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SIO_000300: 2.79e0

GenotypeDepth
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variant carriers: 0

GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 1

African
type: Population
allele count: 1
allele frequency: 1.508295625942685e-4
allele num: 6630
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 9586
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6274
num of homozygotes: 0

European (Non-Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 43504
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 12962
num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

ClippingRankSum
type: SiteQuality
SIO_000300: 7.04e-1

DP
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FS
type: SiteQuality
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ReadPosRankSum
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VQSLOD
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MQ
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MQRankSum
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QD
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BaseQRankSum
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InbreedingCoeff
type: SiteQuality
SIO_000300: -5.0e-3

GenotypeDepth
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variant carriers: 1

GenotypeDepth
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variant carriers: 3

GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
all individuals: 751
bin: 9.75e1
variant carriers: 19

Latino
type: Population
allele count: 1
allele frequency: 1.038205980066445e-4
allele num: 9632
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

African
type: Population
allele count: 1
allele frequency: 1.503307276007216e-4
allele num: 6652
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 14
allele frequency: 3.203074951953876e-4
allele num: 43708
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 662
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European (Finnish)
type: Population
allele count: 1
allele frequency: 2.05761316872428e-4
allele num: 4860
num of homozygotes: 0

DP
type: SiteQuality
SIO_000300: 1.022346e6

VQSLOD
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MQRankSum
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BaseQRankSum
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FS
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SIO_000300: 1.963e0

ClippingRankSum
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SIO_000300: -2.99e-1

ReadPosRankSum
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QD
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MQ
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InbreedingCoeff
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SIO_000300: -5.1e-3

GenotypeDepth
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variant carriers: 0

GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 4.75e1
variant carriers: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 4862
num of homozygotes: 0

Latino
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allele count: 17
allele frequency: 1.762023217247098e-3
allele num: 9648
num of homozygotes: 1

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 662
num of homozygotes: 0

European (Non-Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 43792
num of homozygotes: 0

African
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allele frequency: 0.0e0
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South Asian
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allele frequency: 0.0e0
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num of homozygotes: 0

East Asian
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allele frequency: 0.0e0
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VQSLOD
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FS
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MQRankSum
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ClippingRankSum
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MQ
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ReadPosRankSum
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DP
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InbreedingCoeff
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QD
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BaseQRankSum
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

European (Non-Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 47068
num of homozygotes: 0

Latino
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allele count: 1
allele frequency: 1.008267795926598e-4
allele num: 9918
num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 5148
num of homozygotes: 0

African
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

Other
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South Asian
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East Asian
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num of homozygotes: 0

InbreedingCoeff
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BaseQRankSum
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SIO_000300: -3.9e-2

ReadPosRankSum
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MQ
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SIO_000300: 5.787e1

VQSLOD
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QD
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FS
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SIO_000300: 5.09e0

MQRankSum
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SIO_000300: 5.91e-1

ClippingRankSum
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DP
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SIO_000300: 1.132781e6

GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

European (Non-Finnish)
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allele count: 1
allele frequency: 2.080559254327563e-5
allele num: 48064
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 704
num of homozygotes: 0

African
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

South Asian
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

Latino
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allele frequency: 0.0e0
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num of homozygotes: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

DP
type: SiteQuality
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VQSLOD
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ClippingRankSum
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MQRankSum
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MQ
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ReadPosRankSum
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InbreedingCoeff
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SIO_000300: -2.6e-3

BaseQRankSum
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SIO_000300: -2.7e-1

FS
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SIO_000300: 4.415e0

QD
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GenotypeDepth
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variant carriers: 0

GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
allele num: 7066
num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

African
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

Other
type: Population
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allele frequency: 0.0e0
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Latino
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South Asian
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allele frequency: 0.0e0
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European (Non-Finnish)
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allele num: 48008
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MQRankSum
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InbreedingCoeff
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MQ
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BaseQRankSum
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VQSLOD
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ClippingRankSum
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FS
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DP
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QD
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ReadPosRankSum
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GenotypeDepth
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variant carriers: 1

GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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Latino
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num of homozygotes: 0

South Asian
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Other
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East Asian
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European (Finnish)
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European (Non-Finnish)
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African
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InbreedingCoeff
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QD
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BaseQRankSum
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FS
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MQRankSum
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VQSLOD
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ClippingRankSum
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ReadPosRankSum
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MQ
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DP
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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European (Non-Finnish)
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East Asian
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African
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Latino
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South Asian
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European (Finnish)
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Other
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DP
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ClippingRankSum
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VQSLOD
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InbreedingCoeff
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MQRankSum
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FS
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QD
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MQ
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BaseQRankSum
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ReadPosRankSum
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GenotypeDepth
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variant carriers: 0

GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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European (Non-Finnish)
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VQSLOD
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ReadPosRankSum
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MQRankSum
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MQ
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FS
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DP
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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African
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South Asian
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DP
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FS
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MQRankSum
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VQSLOD
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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African
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East Asian
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European (Finnish)
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Latino
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European (Non-Finnish)
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DP
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MQ
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VQSLOD
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MQRankSum
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InbreedingCoeff
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FS
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ReadPosRankSum
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QD
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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African
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Latino
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European (Non-Finnish)
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European (Finnish)
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Other
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East Asian
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ClippingRankSum
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ReadPosRankSum
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MQ
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DP
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MQRankSum
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VQSLOD
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FS
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BaseQRankSum
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InbreedingCoeff
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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European (Non-Finnish)
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European (Finnish)
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African
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South Asian
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Latino
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MQ
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VQSLOD
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QD
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FS
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MQRankSum
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BaseQRankSum
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InbreedingCoeff
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DP
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ClippingRankSum
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GenotypeQuality
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GenotypeQuality
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European (Non-Finnish)
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European (Finnish)
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African
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VQSLOD
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FS
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MQ
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DP
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InbreedingCoeff
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BaseQRankSum
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European (Non-Finnish)
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African
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MQ
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DP
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InbreedingCoeff
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VQSLOD
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FS
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QD
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BaseQRankSum
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SIO_000300: 3.36e-1

GenotypeDepth
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variant carriers: 0

GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
all individuals: 107
bin: 4.25e1
variant carriers: 0

European (Non-Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 19524
num of homozygotes: 0

Other
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allele count: 1
allele frequency: 2.777777777777778e-3
allele num: 360
num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

African
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

Latino
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

South Asian
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allele count: 1
allele frequency: 1.02082482645978e-4
allele num: 9796
num of homozygotes: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
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InbreedingCoeff
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SIO_000300: -3.84e-2

DP
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ClippingRankSum
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ReadPosRankSum
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MQRankSum
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FS
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QD
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VQSLOD
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BaseQRankSum
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SIO_000300: -3.61e-1

MQ
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SIO_000300: 6.0e1

GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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South Asian
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allele count: 0
allele frequency: 0.0e0
allele num: 8838
num of homozygotes: 0

Latino
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allele count: 1
allele frequency: 3.32667997338656e-4
allele num: 3006
num of homozygotes: 0

African
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
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European (Finnish)
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 288
num of homozygotes: 0

European (Non-Finnish)
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allele count: 0
allele frequency: 0.0e0
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ClippingRankSum
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SIO_000300: 1.33e-1

InbreedingCoeff
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ReadPosRankSum
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MQ
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FS
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VQSLOD
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BaseQRankSum
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DP
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MQRankSum
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SIO_000300: 1.71e-1

QD
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SIO_000300: 9.699999999999999e0

GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 2

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 262
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 3
allele frequency: 2.692031586503948e-4
allele num: 11144
num of homozygotes: 0

Latino
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
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African
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allele count: 1
allele frequency: 4.142502071251035e-4
allele num: 2414
num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
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South Asian
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allele count: 18
allele frequency: 2.179176755447942e-3
allele num: 8260
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InbreedingCoeff
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SIO_000300: 4.22e-2

ClippingRankSum
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MQRankSum
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MQ
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VQSLOD
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BaseQRankSum
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SIO_000300: 2.02e0

FS
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SIO_000300: 0.0e0

ReadPosRankSum
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SIO_000300: 4.21e-1

QD
type: SiteQuality
SIO_000300: 1.438e1

DP
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SIO_000300: 4.41517e5

GenotypeDepth
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variant carriers: 1

GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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European (Non-Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 65206
num of homozygotes: 0

Latino
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allele count: 0
allele frequency: 0.0e0
allele num: 11502
num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
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Other
type: Population
allele count: 0
allele frequency: 0.0e0
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African
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allele count: 0
allele frequency: 0.0e0
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South Asian
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allele count: 2
allele frequency: 1.374192661811186e-4
allele num: 14554
num of homozygotes: 0

East Asian
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allele count: 0
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MQRankSum
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FS
type: SiteQuality
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InbreedingCoeff
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DP
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VQSLOD
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QD
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BaseQRankSum
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MQ
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SIO_000300: 6.149e1

ReadPosRankSum
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SIO_000300: 1.3e-2

ClippingRankSum
type: SiteQuality
SIO_000300: 5.3e-1

GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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Other
type: Population
allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

African
type: Population
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allele frequency: 1.957330201605011e-4
allele num: 10218
num of homozygotes: 0

European (Non-Finnish)
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allele frequency: 0.0e0
allele num: 65260
num of homozygotes: 0

Latino
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allele count: 0
allele frequency: 0.0e0
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European (Finnish)
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East Asian
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South Asian
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VQSLOD
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InbreedingCoeff
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FS
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BaseQRankSum
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MQ
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ClippingRankSum
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MQRankSum
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ReadPosRankSum
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DP
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QD
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 872
num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

East Asian
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African
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allele frequency: 0.0e0
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Latino
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South Asian
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allele frequency: 0.0e0
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European (Non-Finnish)
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FS
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InbreedingCoeff
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DP
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ReadPosRankSum
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ClippingRankSum
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MQRankSum
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QD
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VQSLOD
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BaseQRankSum
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MQ
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Other
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European (Finnish)
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African
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East Asian
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allele frequency: 0.0e0
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European (Non-Finnish)
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MQRankSum
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BaseQRankSum
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VQSLOD
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InbreedingCoeff
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QD
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ClippingRankSum
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MQ
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FS
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ReadPosRankSum
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DP
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 9.75e1
variant carriers: 8

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 6554
num of homozygotes: 0

South Asian
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allele frequency: 0.0e0
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num of homozygotes: 0

Latino
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

Other
type: Population
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allele frequency: 0.0e0
allele num: 872
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10230
num of homozygotes: 0

European (Non-Finnish)
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allele count: 8
allele frequency: 1.224739742804654e-4
allele num: 65320
num of homozygotes: 0

VQSLOD
type: SiteQuality
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DP
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MQ
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QD
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ClippingRankSum
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SIO_000300: 1.04e-1

MQRankSum
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InbreedingCoeff
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SIO_000300: 7.0e-4

FS
type: SiteQuality
SIO_000300: 1.32e0

ReadPosRankSum
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SIO_000300: 6.39e-1

BaseQRankSum
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SIO_000300: -2.82e0

GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

African
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allele count: 0
allele frequency: 0.0e0
allele num: 10244
num of homozygotes: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
allele num: 8594
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 14874
num of homozygotes: 0

European (Non-Finnish)
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allele count: 1
allele frequency: 1.528911720637251e-5
allele num: 65406
num of homozygotes: 0

Latino
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allele frequency: 0.0e0
allele num: 11506
num of homozygotes: 0

Other
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allele count: 0
allele frequency: 0.0e0
allele num: 882
num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 6558
num of homozygotes: 0

VQSLOD
type: SiteQuality
SIO_000300: -1.853e0

ReadPosRankSum
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DP
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SIO_000300: 1.590033e6

BaseQRankSum
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MQ
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QD
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FS
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SIO_000300: 0.0e0

InbreedingCoeff
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SIO_000300: 1.6e-3

ClippingRankSum
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SIO_000300: 1.85e-1

MQRankSum
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SIO_000300: 1.66e0

GenotypeDepth
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variant carriers: 1

GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 0

Latino
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allele count: 0
allele frequency: 0.0e0
allele num: 11506
num of homozygotes: 0

European (Non-Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 65600
num of homozygotes: 0

South Asian
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allele count: 0
allele frequency: 0.0e0
allele num: 15192
num of homozygotes: 0

African
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allele count: 0
allele frequency: 0.0e0
allele num: 10266
num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 6556
num of homozygotes: 0

East Asian
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allele count: 6
allele frequency: 6.976744186046512e-4
allele num: 8600
num of homozygotes: 0

Other
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

InbreedingCoeff
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VQSLOD
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MQRankSum
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ClippingRankSum
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QD
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DP
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FS
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SIO_000300: 5.38e-1

MQ
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SIO_000300: 5.944e1

ReadPosRankSum
type: SiteQuality
SIO_000300: -4.1e-2

BaseQRankSum
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SIO_000300: -1.766e0

GenotypeDepth
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variant carriers: 0

GenotypeDepth
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variant carriers: 0

GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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variant carriers: 1

GenotypeQuality
all individuals: 280
bin: 9.25e1
variant carriers: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.523554147114388e-5
allele num: 65636
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 15294
num of homozygotes: 0

Latino
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allele count: 0
allele frequency: 0.0e0
allele num: 11510
num of homozygotes: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
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African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10274
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

QD
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SIO_000300: 2.64e0

VQSLOD
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ReadPosRankSum
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SIO_000300: -1.54e-1

MQ
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MQRankSum
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SIO_000300: -9.85e-1

FS
type: SiteQuality
SIO_000300: 6.830000000000001e-1

InbreedingCoeff
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SIO_000300: 5.1e-3

BaseQRankSum
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SIO_000300: -1.051e0

ClippingRankSum
type: SiteQuality
SIO_000300: 2.22e-1

DP
type: SiteQuality
SIO_000300: 1.607189e6

GenotypeDepth
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variant carriers: 0

GenotypeDepth
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variant carriers: 0

GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 9.75e1
variant carriers: 1

European (Non-Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 65636
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

East Asian
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allele frequency: 0.0e0
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num of homozygotes: 0

South Asian
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allele count: 1
allele frequency: 6.53851183470642e-5
allele num: 15294
num of homozygotes: 0

Latino
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allele count: 0
allele frequency: 0.0e0
allele num: 11510
num of homozygotes: 0

European (Finnish)
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allele count: 0
allele frequency: 0.0e0
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num of homozygotes: 0

Other
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allele frequency: 0.0e0
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BaseQRankSum
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SIO_000300: -1.051e0

FS
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SIO_000300: 6.830000000000001e-1

QD
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InbreedingCoeff
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VQSLOD
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MQRankSum
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ReadPosRankSum
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DP
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SIO_000300: 1.607189e6

ClippingRankSum
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SIO_000300: 2.22e-1

MQ
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SIO_000300: 6.0e1

GenotypeDepth
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variant carriers: 0

GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 9.75e1
variant carriers: 1

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6558
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 2
allele frequency: 3.047108294228777e-5
allele num: 65636
num of homozygotes: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
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Latino
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allele count: 0
allele frequency: 0.0e0
allele num: 11510
num of homozygotes: 0

African
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allele count: 0
allele frequency: 0.0e0
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South Asian
type: Population
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num of homozygotes: 0

Other
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allele count: 0
allele frequency: 0.0e0
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BaseQRankSum
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SIO_000300: -1.051e0

QD
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VQSLOD
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FS
type: SiteQuality
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ReadPosRankSum
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InbreedingCoeff
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ClippingRankSum
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MQRankSum
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MQ
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DP
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GenotypeDepth
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variant carriers: 28

GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
all individuals: 1486
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GenotypeQuality
all individuals: 614
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Latino
type: Population
allele count: 43
allele frequency: 3.73328702899809e-3
allele num: 11518
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 579
allele frequency: 8.798322392414296e-3
allele num: 65808
num of homozygotes: 2

Other
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allele count: 4
allele frequency: 4.484304932735426e-3
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num of homozygotes: 0

South Asian
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allele count: 6
allele frequency: 3.843689942344651e-4
allele num: 15610
num of homozygotes: 0

African
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allele count: 9
allele frequency: 8.741258741258741e-4
allele num: 10296
num of homozygotes: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
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European (Finnish)
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allele count: 7
allele frequency: 1.069355331500153e-3
allele num: 6546
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VQSLOD
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ClippingRankSum
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MQRankSum
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QD
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InbreedingCoeff
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BaseQRankSum
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FS
type: SiteQuality
SIO_000300: 5.34e-1

MQ
type: SiteQuality
SIO_000300: 5.973e1

DP
type: SiteQuality
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ReadPosRankSum
type: SiteQuality
SIO_000300: 3.46e-1

GenotypeDepth
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variant carriers: 0

GenotypeDepth
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GenotypeDepth
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GenotypeDepth
all individuals: 10413
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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bin: 2.75e1
variant carriers: 0

European (Non-Finnish)
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allele count: 0
allele frequency: 0.0e0
allele num: 65840
num of homozygotes: 0

Latino
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allele frequency: 0.0e0
allele num: 11520
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South Asian
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allele num: 15724
num of homozygotes: 0

European (Finnish)
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allele frequency: 0.0e0
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num of homozygotes: 0

African
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allele frequency: 0.0e0
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Other
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East Asian
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QD
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MQ
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ClippingRankSum
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DP
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InbreedingCoeff
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FS
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BaseQRankSum
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MQRankSum
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ReadPosRankSum
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VQSLOD
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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South Asian
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allele frequency: 0.0e0
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num of homozygotes: 0

East Asian
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allele count: 0
allele frequency: 0.0e0
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Latino
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allele frequency: 8.677542519958348e-5
allele num: 11524
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Other
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African
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allele frequency: 0.0e0
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European (Non-Finnish)
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allele count: 0
allele frequency: 0.0e0
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European (Finnish)
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BaseQRankSum
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VQSLOD
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MQRankSum
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FS
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InbreedingCoeff
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ReadPosRankSum
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ClippingRankSum
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DP
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MQ
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QD
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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African
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num of homozygotes: 0

Latino
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allele frequency: 0.0e0
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num of homozygotes: 0

South Asian
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European (Non-Finnish)
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European (Finnish)
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allele frequency: 0.0e0
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East Asian
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Other
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InbreedingCoeff
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FS
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DP
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VQSLOD
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BaseQRankSum
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ClippingRankSum
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MQ
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MQRankSum
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ReadPosRankSum
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QD
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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African
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num of homozygotes: 0

South Asian
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European (Non-Finnish)
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East Asian
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Other
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Latino
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European (Finnish)
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MQRankSum
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DP
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QD
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InbreedingCoeff
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FS
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MQ
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VQSLOD
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ReadPosRankSum
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ClippingRankSum
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BaseQRankSum
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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East Asian
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num of homozygotes: 0

European (Finnish)
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South Asian
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African
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Other
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European (Non-Finnish)
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Latino
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FS
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VQSLOD
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QD
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BaseQRankSum
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MQRankSum
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InbreedingCoeff
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DP
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ReadPosRankSum
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MQ
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ClippingRankSum
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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African
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num of homozygotes: 0

South Asian
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European (Finnish)
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East Asian
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Latino
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Other
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European (Non-Finnish)
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MQ
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ClippingRankSum
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ReadPosRankSum
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BaseQRankSum
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InbreedingCoeff
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QD
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DP
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MQRankSum
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FS
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VQSLOD
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeDepth
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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GenotypeQuality
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Latino
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allele count: 0
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num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16346
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8598
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10298
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.512127260630255e-5
allele num: 66132
num of homozygotes: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6458
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 898
num of homozygotes: 0

ReadPosRankSum
type: SiteQuality
SIO_000300: 7.02e-1

MQ
type: SiteQuality
SIO_000300: 6.0e1

DP
type: SiteQuality
SIO_000300: 1.623722e6

ClippingRankSum
type: SiteQuality
SIO_000300: 1.52e-1

BaseQRankSum
type: SiteQuality
SIO_000300: -2.072e0

QD
type: SiteQuality
SIO_000300: 1.296e1

InbreedingCoeff
type: SiteQuality
SIO_000300: -2.0e-4

MQRankSum
type: SiteQuality
SIO_000300: 1.0e0

FS
type: SiteQuality
SIO_000300: 0.0e0

VQSLOD
type: SiteQuality
SIO_000300: 6.98e-1

GenotypeDepth
all individuals: 83
bin: 5.75e1
variant carriers: 0

GenotypeDepth
all individuals: 289
bin: 1.75e1
variant carriers: 0

GenotypeDepth
all individuals: 3
bin: 8.25e1
variant carriers: 0

GenotypeDepth
all individuals: 612
bin: 7.5e0
variant carriers: 0

GenotypeDepth
all individuals: 418
bin: 4.25e1
variant carriers: 0

GenotypeDepth
all individuals: 10
bin: 8.75e1
variant carriers: 0

GenotypeQuality
all individuals: 126
bin: 3.75e1
variant carriers: 0

GenotypeQuality
all individuals: 974
bin: 2.25e1
variant carriers: 0

GenotypeQuality
all individuals: 2
bin: 2.5e0
variant carriers: 0

GenotypeQuality
all individuals: 151
bin: 3.25e1
variant carriers: 0

GenotypeQuality
all individuals: 46744
bin: 6.25e1
variant carriers: 0

GenotypeQuality
all individuals: 7
bin: 1.25e1
variant carriers: 0

GenotypeQuality
all individuals: 64
bin: 4.25e1
variant carriers: 0

GenotypeQuality
all individuals: 9
bin: 1.75e1
variant carriers: 0

GenotypeQuality
all individuals: 22
bin: 7.5e0
variant carriers: 0

GenotypeQuality
all individuals: 807
bin: 9.75e1
variant carriers: 1

GenotypeQuality
all individuals: 143
bin: 2.75e1
variant carriers: 0

GenotypeQuality
all individuals: 189
bin: 8.75e1
variant carriers: 0

GenotypeQuality
all individuals: 118
bin: 5.25e1
variant carriers: 0

GenotypeQuality
all individuals: 1399
bin: 7.75e1
variant carriers: 0

GenotypeQuality
all individuals: 595
bin: 8.25e1
variant carriers: 0

GenotypeQuality
all individuals: 7346
bin: 6.75e1
variant carriers: 0

GenotypeQuality
all individuals: 1619
bin: 7.25e1
variant carriers: 0

GenotypeQuality
all individuals: 96
bin: 4.75e1
variant carriers: 0

GenotypeQuality
all individuals: 65
bin: 5.75e1
variant carriers: 0

GenotypeQuality
all individuals: 230
bin: 9.25e1
variant carriers: 0

European (Finnish)
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 6428
num of homozygotes: 0

European (Non-Finnish)
type: Population
allele count: 1
allele frequency: 1.512996641147457e-5
allele num: 66094
num of homozygotes: 0

African
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 10272
num of homozygotes: 0

Latino
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 11490
num of homozygotes: 0

East Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 8594
num of homozygotes: 0

Other
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 898
num of homozygotes: 0

South Asian
type: Population
allele count: 0
allele frequency: 0.0e0
allele num: 16356
num of homozygotes: 0

DP
type: SiteQuality
SIO_000300: 1.621928e6

InbreedingCoeff
type: SiteQuality
SIO_000300: -2.0e-4

MQRankSum
type: SiteQuality
SIO_000300: 4.73e-1

QD
type: SiteQuality
SIO_000300: 7.25e0

BaseQRankSum
type: SiteQuality
SIO_000300: -4.73e-1

ClippingRankSum
type: SiteQuality
SIO_000300: -4.73e-1

MQ
type: SiteQuality
SIO_000300: 6.0e1

VQSLOD
type: SiteQuality
SIO_000300: -2.705e-1

FS
type: SiteQuality
SIO_000300: 3.796e0

ReadPosRankSum
type: SiteQuality
SIO_000300: 6.889999999999999e-1