Phosphatidylserine decarboxylase alpha chain
Closed Genomes of Seven Mannheimia haemolytica isolates.
Binds 1 pyruvoyl group covalently per subunit.
Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily.
Phosphatidylserine decarboxylase beta chain
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.
Cleavage (non-hydrolytic); by autocatalysis
Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
Charge relay system; for autoendoproteolytic cleavage activity
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Phosphatidylserine decarboxylase proenzyme
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
Recombination of ecologically and evolutionarily significant loci maintains genetic cohesion in the Pseudomonas syringae species complex.
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
Genome announcement of multiple Pseudomonas syringae strains.
GenomeTrakr network: Whole genome sequencing for foodborne pathogen traceback
PulseNet: The National Subtyping Network for Foodborne Disease Surveillance
F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
Belongs to the ATPase epsilon chain family.
Whole genome PacBio Sequel sequence of Salmonella enterica subsp. enterica.
Produces ATP from ADP in the presence of a proton gradient across the membrane.
UDP-N-acetyl-D-mannosamine dehydrogenase
Substrate binding; shared with dimeric partner
Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily.
Catalyzes the four-electron oxidation of UDP-N-acetyl-D-mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N-acetylmannosaminuronic acid (UDP-ManNAcA).
The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.
Sec-independent protein translocase protein TatC
The Salmonella typhimurium Genome Sequencing Project.
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): Supporting development and validation of Infectious Disease Dx tests.
Belongs to the methylenetetrahydrofolate reductase family.
Proton acceptor; specific for (R)-substrate epimerization
Belongs to the mandelate racemase/muconate lactonizing enzyme family.
Proton acceptor; specific for (S)-substrate epimerization
Homodimerization via its hinge domain. Binds to DNA via its C-terminal region. Interacts, and probably forms a ternary complex, with MukE and MukF via its C-terminal region. The complex formation is stimulated by calcium or magnesium. Interacts with tubulin-related protein FtsZ.
Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division.
The hinge domain, which separates the large intramolecular coiled coil regions, allows the homodimerization, forming a V-shaped homodimer.
Structural maintenance of chromosome-related protein
Belongs to the SMC family. MukB subfamily.
Binds 2 magnesium or manganese ions per subunit.
Belongs to the D-alanine--D-alanine ligase family.
Whole-Genome Sequences of Acinetobacter spp Isolated From Dairy Cow Manure.
Genetic environment of the oxa23 gene and comparative analysis of carbapenem resistant Acinetobacter baumannii isolates belonging to global clone 1, lineage 2 recovered in a burns hospital outbreak in 2012-2013.
The complete genome of Acinetobacter baumannii strain WCHAB005078.
A novel plasmid carries a functional mcr-4.3 gene in a colistin-resistant Acinetobacter baumannii clinical strain.
Comparative genomics and transcriptomics of Acinetobacter baumannii.
Complete Genome Sequence of Four Extensively Drug-Resistant Acinetobacter buamannii Isolated from Clinical Samples in Thailand.
Resistance determinants and their genetic context in bacteria from a longitudinal study of pigs reared under conventional and antibiotic-free husbandry practices.
Diversity of carbapenem-resistant Acinetobacter baumannii and bacteriophage-mediated spread of the Oxa23 carbapenemase.
Carbapenemase-producing Acinetobacter spp. from environmental sources in an hospital from French Polynesia.
Draft Genomes of Two Acinetobacter baumannii Isolates from Fatal Necrotizing Fasciitis.
Multiplied blaOXA-23-transposons in the genome of Acinetobacter spp. as an adaptive mechanism for bacteria encountering carbapenems.
A Diverse Panel of Clinical Acinetobacter baumannii for Research Use.
Optimizing a Whole-Genome Sequencing Data Processing Pipeline for Precision Surveillance of Healthcare-Associated Infections.
Complete genome of Carbapenem Resistant Acinetobacter baumannii.
Whole-genome sequence analysis of carbapanemase producing Acinetobacter baumannii isolates from Ghana.
Genome sequencing of Acinetobacter baumannii strain CAM180.
Resequencing Analysis and Multi-drug Resistance Differences of Acinetobacter baumannii in Chongqing, China.
Draft genome of Acinetobacter baumannii strain I43, a mercury resistant bacteria.
Multidrug-resistant Acinetobacter baumannii moving toward extensively drug-resistant over fifteen years in South of Brazil.
Distinct mechanisms of dissemination of NDM-1 metallo-beta-betalactamase in Acinetobacter species spp. in Argentina.
Genomic Dynamics of Species and Mobile Genetic Elements in a Prolonged blaIMP-4-associated Carbapenemase Outbreak in an Australian Hospital.
Complete genome sequencing of Acinetobacter baumannii AC1633 and Acinetobacter nosocomialis AC1530 unveils a large multidrug resistant plasmid encoding the NDM-1 and OXA-58 carbapenemases.
blaOXA beta-lactamases are the sole determinants in mediating carbapenem resistance in Acinetobacter baumannii of clinical origins.
Evolution of Acinetobacter baumannii plasmids.
Genomic Analysis of Hospital Plumbing Reveals Diverse Reservoir of Bacterial Plasmids Conferring Carbapenem Resistance.
Genome analysis of an Acinetobacter baumannii outbreak in hospital ICU in China.
Whole genome shot-gun sequencing of clinical Carbapenem resistant A. baumannii.
Draft genome sequence of MDR A. baumannii AB360.
The evolution of oxa-23 in Acinetobacter baumanni.
Carbapenem resistant Acinetobacter baumannii_VB33071_hybrid assembly.
The utility of whole genome sequencing in characterizing Acinetobacter epidemiology and analyzing hospital outbreaks.
GWAS and RNA-Seq identify cryptic mechanisms of antimicrobial resistance in Acinetobacter baumannii.
Epidemiology and genetic characterization of 247 CRAB isolated from infections.
10 Multi-Drug Resistant Acinetobacter Baumannii Strains for ARLG-ICMR From India.
FDA/CDC Antimicrobial Resistant Isolate Bank Genome Sequencing.
Acinetobacter baumannii genome sequencing and assembly.
Carbapenem resistant Acinetobacter baumannii_VB31459_hybrid assembly.
Assembly of Acinetobacter baumannii genome AF-673 with blaOXA-235 gene.
The evolution of Acinetobacter baumannii in vivo.
Genome Sequence of Pseudomonas citronellolis Strain SJTE-3, an Estrogens and Persistent Organic Pollutants degradation strain.
The full genome sequence of Pseudomonas citronellolis P3B5, an alkane degrading bacterium with considerable biochemical interest isolated from basil leaves.
With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
Heterodimer composed of CysD, the smaller subunit, and CysN.
Keeping alert to hypervirulent salmonella strains isolated from avain.
genome sequence of LSP 389/97, an isolate of the Spanish clone of Salmonella enterica 4,5,12,i:-.
NAD-dependent dihydropyrimidine dehydrogenase subunit PreT
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein.
Sulfite reductase [NADPH] flavoprotein alpha-component
Escherichia hongkongenesis sp. nov., isolated from subtropical aquatic environment.
Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family.
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.
In the N-terminal section; belongs to the flavodoxin family.
Genetic diversity of 'environment-specific' Escherichia coli strains: expanding the understanding of the ecology and evolution of the model bacterial species.
Heterotetramer of two alpha and two beta subunits.
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
Belongs to the succinate/malate CoA ligase alpha subunit family.
The pathways for chlorine oxyanion respiration interact through the shared metabolite chlorate.
Succinate--CoA ligase [ADP-forming] subunit alpha
Draft genome sequence of the halophilic bacterium Marinobacter vinifirmus FB1.
Food and environmental bacterial isolates.
Putative spermidine/putrescine transport system ATP-binding protein
Genome sequencing of rice bacterial endophytes.
Characterization of a multidrug resistant Citrobacter pasteurii.
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
Population genomics of rice bacterial leaf blight strains from India.
Complete genome investigation of Xanthomonas oryzae strains.
Lacks conserved residue(s) required for the propagation of feature annotation.
Non-Typhoidal Salmonella genome sequencing and assembly.
Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.
The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.
NARMS: The National Antimicrobial Resistance Monitoring System
In the N-terminal section; belongs to the CobB/CobQ family.
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
Thiol:disulfide interchange protein DsbE
Belongs to the thioredoxin family. DsbE subfamily.
Belongs to the LysR transcriptional regulatory family.
Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
Complete Genome Sequencing of Serratia Fonticola DSM-4576.
Belongs to the peptidase M20A family. DapE subfamily.
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
Binds 2 Zn(2+) or Co(2+) ions per subunit.
N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase
Draft Genome Sequences of 72 Isolates from All Four Species of Shigella.
Complete genome sequencing of Shigella boydii.
DNA-binding transcriptional regulator XylR
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
complete genome sequences of Aeromonas media str. WP7-W18-ESBL-02 isolated from wastewater treatment plant effluent.
Novel transposon Tn6433 accelerates the dissemination of tet(E) in Aeromonas from aerobic biofilm under oxytetracycline stress.
Forms a heterotetramer with UvrB during the search for lesions.
Belongs to the ABC transporter superfamily. UvrA family.
With S5 and S12 plays an important role in translational accuracy.
Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
Belongs to the universal ribosomal protein uS4 family.
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
Catalyzes the ferrous insertion into protoporphyrin IX.
Methyltransferase domain-containing protein
Belongs to the methyltransferase superfamily. RsmJ family.
Ribosomal RNA small subunit methyltransferase J
Specifically methylates the guanosine in position 1516 of 16S rRNA.
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
Belongs to the uroporphyrinogen decarboxylase family.
Arginine ABC transporter substrate-binding protein
Belongs to the bacterial solute-binding protein 3 family.
Whole genome sequencing of Salmonella enterica.
Belongs to the radical SAM superfamily. RlmN family.
Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
tRNA (adenine(37)-C(2))-methyltransferase
Whole genome sequencing of cultured pathogen.
Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
Ribosomal RNA large subunit methyltransferase N
Dual-specificity RNA methyltransferase RlmN
23S rRNA (adenine(2503)-C(2))-methyltransferase
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
Low-potential electron donor to a number of redox enzymes.
23S rRNA (cytidine2498-2'-O)-methyltransferase
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
23S rRNA 2'-O-ribose methyltransferase RlmM
Ribosomal RNA large subunit methyltransferase M
Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
Belongs to the rhamnose isomerase family.
Polydeoxyribonucleotide synthase [NAD(+)] B
Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction.
Belongs to the NAD-dependent DNA ligase family. LigB subfamily.
Belongs to the methyltransferase superfamily. RsmD family.
Ribosomal RNA small subunit methyltransferase D
Draft Genome sequences of multiple microbial strains isolated from spacecraft associated surfaces.
Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle.
Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase.
Comparative genomic analysis of the Hafnia genus genomes.
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
Belongs to the universal ribosomal protein uL24 family.
Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
7,8-diamino-pelargonic acid aminotransferase
A complete genome sequence for Pseudomonas syringae CC1524.
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
Proton donor; for transglycosylase activity
Acyl-ester intermediate; for transpeptidase activity
Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits).
In the C-terminal section; belongs to the transpeptidase family.
In the N-terminal section; belongs to the glycosyltransferase 51 family.
Probably plays an important role in intracellular peptide degradation.
NDM-1-producing Klebsiella pneumoniae in a Nephrology Transplant Intensive Care Unit: Role of Environmental Reservoir.
Dibenzothiophene desulfurization enzyme C
Isopentenyl-diphosphate:tRNA isopentenyltransferase
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
Dimethylallyl diphosphate:tRNA dimethylallyltransferase
Serves to protect cells from the toxic effects of hydrogen peroxide.
Belongs to the catalase family. HPII subfamily.
Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
A multidrug resistance plasmid contains the molecular switch for type VI secretion in Acinetobacter baumannii.
Meningitis Acinetobacter baumannii strain ABIQM1 whole genome mutational and funactional analysis.
Complete genome sequencing for A.baumanii.
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
Belongs to the universal ribosomal protein uL13 family.
Belongs to the adrenodoxin/putidaredoxin family.
Towards the description of the genomic repertoire of the Pseudomonas citronellolis strain DSM50332(T).
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
Whole genome shotgun sequence of Acinetobacter radioresistens NBRC 102413.
The Broad Institute Genome Sequencing Center for Infectious Disease
Belongs to the bacterial ribosomal protein bL20 family.
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.
The Broad Institute Genome Sequencing Platform
The Genome Sequence of Acinetobacter radioresistens CIP 103788.
Belongs to the ATPase alpha/beta chains family. T3SS ATPase subfamily.
Xanthomonas oryzae pv. oryzae - African strains.
F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has four main subunits: a(1), b(1), b'(1) and c(9-12).
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.
Phosphohydroxythreonine aminotransferase
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
Binds 1 pyridoxal phosphate per subunit.
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
Belongs to the band 7/mec-2 family. HflC subfamily.
HflC and HflK could regulate a protease.
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase
Ribose operon transcriptional repressor RbsR
Plays a key role in the stabilization of the transition state and positioning the aldehyde component
Involved in the degradation of L-fucose and D-arabinose. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.
Belongs to the aldolase class II family. AraD/FucA subfamily.
Cysteine/glutathione ABC transporter membrane /ATP-binding protein
Cysteine/glutathione ABC transporter ATP-binding protein/permease CydC
(2,3-dihydroxybenzoyl)adenylate synthase
Efflux RND transporter periplasmic adaptor subunit
Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
Iron ABC transporter ATP-binding protein FetA
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
ligand shared between two neighboring subunits
Draft genome sequence of various Type strains from the CCUG.
Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.
DNA-binding transcriptional LysR family regulator
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ
Belongs to the thioester dehydratase family. FabZ subfamily.
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
Updated taxonomy of Pectobacterium genus in the CIRM-CFBP bacterial collection: when new species reveal old endemic population.
Genome Sequence of Pectobacterium carotovorum 2A.
Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals.
Putative transcriptional regulator of the myo-inositol catabolic operon
MurR/RpiR family transcriptional regulator
Complete genome sequence of Serratia sp. ATCC 39006.
Complete genome sequence of Serratia sp. ATCC 39006 LacA.
Involved in muropeptide degradation. Catalyzes the hydrolysis of the gamma-D-glutamyl-diaminopimelic acid (gamma-D-Glu-Dap) amide bond in the murein tripeptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelic acid, leading to the formation of L-Ala-gamma-D-Glu and Dap.
Genome sequences of Lysobacter enzymogenes strain C3 and Lysobacter antibioticus ATCC 29479.
Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase
Draft genome of Lysobacter enzymogenes B25.
Intraspecies Signal LeDSF and Interspecies Signal Indole Synergistically Regulate the Twitching Motility of Lysobacter enzymogenes.
In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
Catalyzes the deamination of dCTP to dUTP.
Lrp/AsnC ligand binding domain-containing protein
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
cAMP-activated global transcriptional regulator CRP
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Glycine zipper 2TM domain-containing protein
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
Draft genome sequence of Serratia fonticola 5l isolated from intestinal tract content of a 9000-year-old elk (Alces alces) from permafrost on the Omoloy river.
The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
With S4 and S12 plays an important role in translational accuracy.
Belongs to the universal ribosomal protein uS5 family.
Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
Sigma-70 family RNA polymerase sigma factor
Belongs to the sigma-70 factor family. ECF subfamily.
Belongs to the universal ribosomal protein uL15 family.
Characterisation of Pseudomonas chlororaphis subsp. aurantiaca strain YS05 with the ability to control tomato bacterial spot and wilt disease.
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Ribonucleoside-diphosphate reductase subunit beta
Diversity of phytobeneficial traits revealed by whole-genome analysis of worldwide-isolated phenazine-producing Pseudomonas spp.
Belongs to the ribonucleoside diphosphate reductase small chain family.
Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
Belongs to the DNA mismatch repair MutL/HexB family.
Cystine ABC transporter substrate-binding protein
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
Complete genome sequence of Photobacterium damselae subsp. damselae KC-Na-1 isolated from Neophocaena asiaeorientalis in Korea.
Belongs to the mannitol dehydrogenase family.
Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.
The genome of Lysobacter enzymogenes OH11.
Amino acid adenylation domain-containing protein
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Catalyzes the sodium-dependent uptake of extracellular L-proline.
Propanediol utilization microcompartment protein PduB
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
Draft Genome Sequence of Acinetobacter calcoaceticus Strain P23, a plant growth-promoting bacterium of duckweed.
The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.
Belongs to the pyridoxine kinase family. PdxK subfamily.
B6-vitamer kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxine (PN), pyridoxal (PL), and pyridoxamine (PM), forming their respective 5'-phosphorylated esters, i.e. PNP, PLP and PMP.
Pyridoxine/pyridoxal/pyridoxamine kinase
Belongs to the tRNA-modifying YgfZ family.
Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication.
Belongs to the 6-phosphogluconate dehydrogenase family.
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
6-phosphogluconate dehydrogenase, decarboxylating
Energy-coupling factor ABC transporter ATP-binding protein
Cobalt ABC transporter ATP-binding protein
Specifically methylates the adenine in position 2030 of 23S rRNA.
23S rRNA (adenine(2030)-N6)-methyltransferase
Ribosomal RNA large subunit methyltransferase J
Helix-turn-helix transcriptional regulator
Genome-Wide Identification of 5-Methylcytosine Sites in Bacterial Genomes By High-Throughput Sequencing of MspJI Restriction Fragments.
5-(carboxyamino)imidazole ribonucleotide synthetase
Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
N5-carboxyaminoimidazole ribonucleotide synthase
Holliday junction ATP-dependent DNA helicase RuvB
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
Belongs to the polypeptide deformylase family.
Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. Epd subfamily.
Catalyzes the NAD-dependent conversion of D-erythrose 4-phosphate to 4-phosphoerythronate.
Two-component system response regulator BtsR
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Belongs to the glycosyltransferase 28 family. MurG subfamily.
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
UDP-N-acetyl-alpha-D-glucosamine binding
Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.
Draft genome sequence of Photobacterium damselae subsp. damselae 80077637, isolated from a human clinical case.
Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity.
Photobacterium damselae subsp. damselae isolated from the Black Sea.
Synthesizes selenophosphate from selenide and ATP.
Belongs to the selenophosphate synthase 1 family. Class I subfamily.
Protease Lon-related BREX system protein BrxL
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
Binds 1 thiamine pyrophosphate per subunit.
Belongs to the transketolase family. DXPS subfamily.
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
Belongs to the CRISPR-associated endonuclease Cas1 family.
Homodimer, forms a heterotetramer with a Cas2 homodimer.
NitT/TauT family transport system ATP-binding protein
Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
Belongs to the bacterial diacylglycerol kinase family.
Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.
Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
Interacts with the TusBCD complex. Interacts with MnmA.
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Could accept sulfur from TusD.
Activated by ATP and maltotriose, which are both required for DNA binding.
Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box.
ATP-dependent transcriptional activator MalT
Monomer in solution. Oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose.
3-carboxy-cis,cis-muconate cycloisomerase
Belongs to the mannose-6-phosphate isomerase type 2 family.
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
Ferric uptake regulation protein regulator
Ferric uptake regulation protein (Ferric uptake regulator)
Whole genome sequencing of Histamine producing bacteria.
Belongs to the methyltransferase superfamily. PrmA family.
Complete Genome Sequence of Photobacterium leiognathi JS01.
Binds 2 divalent metal cations per subunit. Magnesium or manganese.
3,4-dihydroxy-2-butanone 4-phosphate synthase
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
Substrate binding; shared with subunit alpha
Succinate--CoA ligase [ADP-forming] subunit beta
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
Belongs to the succinate/malate CoA ligase beta subunit family.
Ribose ABC transporter ATP-binding protein RbsA
Belongs to the heat shock protein 70 family.
Chromosome segregation protein SEQUENCING GAP
Dipeptide transport system permease protein
Dipeptide transport system permease protein dppC
Belongs to the binding-protein-dependent transport system permease family.
RNA polymerase sigma-70 factor, ECF subfamily
Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.
Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.
Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.
NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase
In the N-terminal section; belongs to the malic enzymes family.
Molybdate ABC transporter substrate-binding protein
Belongs to the bacterial solute-binding protein ModA family.
ABC transporter substrate-binding protein
The complex is composed of six subunits: RsxA, RsxB, RsxC, RsxD, RsxE and RsxG.
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Required to maintain the reduced state of SoxR.
Ion-translocating oxidoreductase complex subunit A
Rsx electron transport complex subunit A
Belongs to the glycosyltransferase 56 family.
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis.
TDP-Fuc4NAc:lipid II Fuc4NAc transferase
TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase
Has an organic peroxide-dependent peroxidase activity.
Radical SAM additional 4Fe4S-binding SPASM domain protein
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
Belongs to the aspartate-semialdehyde dehydrogenase family.
Aspartate-beta-semialdehyde dehydrogenase
Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
Belongs to the acetylglutamate kinase family. ArgB subfamily.
N-acetyl-L-glutamate 5-phosphotransferase
Catalyzes a trans-dehydration via an enolate intermediate.
Belongs to the type-II 3-dehydroquinase family.
Monomer. Associates with the 50S ribosomal subunit.
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
Belongs to the glycosyltransferase 4 family. MraY subfamily.
UDP-MurNAc-pentapeptide phosphotransferase
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
Phosphocysteine intermediate; for EIIB activity
An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
Belongs to the polyphosphate kinase 1 (PPK1) family.
Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.
Belongs to the type II topoisomerase family.
Belongs to the type II topoisomerase GyrB family.
Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.
Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.
Belongs to the bacterial ribosomal protein bS1 family.
Homohexamer. Organized in a ring with a central cavity.
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
Catalyzes the transfer of an acetyl group from acetyl-CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring.
Aminoglycoside N(6')-acetyltransferase type 1
Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
Uroporphyrinogen-III C-methyltransferase
In the C-terminal section; belongs to the precorrin methyltransferase family.
In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
Belongs to the precorrin methyltransferase family.
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily.
Succinate dehydrogenase cytochrome b556 subunit
Part of an enzyme complex containing four subunits: a flavoprotein, an iron-sulfur protein, plus two membrane-anchoring proteins, SdhC and SdhD. The complex can form homotrimers.
Membrane-anchoring subunit of succinate dehydrogenase (SDH).
The heme is bound between the two transmembrane subunits.
ligand shared with second transmembrane subunit
Belongs to the disproportionating enzyme family.
Belongs to the PINc/VapC protein family.
Toxic component of a toxin-antitoxin (TA) system. An RNase.
Multidrug efflux MFS transporter periplasmic adaptor subunit EmrA
Multidrug efflux MFS transporter subunit EmrA
Hydrodynamic disturbance controls microbial community assembly and biogeochemical processes in coastal sediments.
Metabolic flexibility allows generalist bacteria to become dominant in a frequently disturbed ecosystem.
NAD(P)-dependent dehydrogenase, short-chain alcohol dehydrogenase family
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
May play a role in metal incorporation in vivo
Belongs to the acireductone dioxygenase (ARD) family.
May play a role in transmitting local conformational changes
Acireductone dioxygenase (Fe(2+)-requiring)
Metabolic potential of the microbial community in the porewater of a deep subsurface clay rock.
Acireductone dioxygenase (Ni(2+)-requiring)
Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
3-methyl-2-oxobutanoate hydroxymethyltransferase
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
3-oxoacyl-[acyl-carrier-protein] reductase
Genome sequences of NCPPB Pectobacterium isolates.
Chaperone-usher fimbriae in a diverse selection of Gallibacterium genomes.
Diversity of Gallibacterium anatis strains isolated from vaccinated chickens.
Essential for recycling GMP and indirectly, cGMP.
Alpha-keto-beta-deoxy-D-glucarate aldolase
Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily.
Catalyzes the reversible retro-aldol cleavage of both 5-keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde.
Genetic Variability of E. coli after antibiotic treatment.
Phage lysis regulatory, LysB family protein
Phosphopantothenoylcysteine decarboxylase
DNA/pantothenate metabolism flavoprotein
In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
Phosphopantothenoylcysteine synthetase/decarboxylase
Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
In the C-terminal section; belongs to the PPC synthetase family.
Coenzyme A biosynthesis bifunctional protein CoaBC
Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
Ribosomal RNA small subunit methyltransferase A
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
Genome Sequence of Cobetia sp. strain AM6 Obtained Using Combined Oxford Nanopore and Illumina Sequencing.
Integrase catalytic domain-containing protein
Required for the transposition of the insertion element.
Genome Sequence of Halomonas sp. strain AM6 Obtained Using Combined Oxford Nanopore and Illumina Sequencing.
Belongs to the acyl-CoA dehydrogenase family.
Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA.
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.
Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
Phage shock protein A (PspA) family protein
Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.
Belongs to the helicase family. DnaB subfamily.
Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.
Dihydrofolate synthase/folylpolyglutamate synthase
Belongs to the folylpolyglutamate synthase family.
Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.
Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
Belongs to the universal ribosomal protein uS14 family.
Belongs to the methylaspartate mutase GlmE subunit family.
Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).
Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.
Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.
Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
4-(2'-carboxyphenyl)-4-oxybutyric acid synthase
De Novo Sequencing of Escherichia coli O157:H- strain 3072/96.
Membrane-bound lysozyme-inhibitor of c-type lysozyme
Flagellar protein that affects chemotactic events.
Phylogenetic diversity of Pectobacterium and Dickeya strains causing blackleg disease of potato in Morocco.
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
Belongs to the band 7/mec-2 family. HflK subfamily.
HflC and HflK could encode or regulate a protease.
HflC and HflK may interact to form a multimeric complex.
Oxygen-dependent coproporphyrinogen-III oxidase
Belongs to the aerobic coproporphyrinogen-III oxidase family.
Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
Type III restriction endonuclease subunit R
Type III restriction-modification system endonuclease
Belongs to the DadA oxidoreductase family.
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
Part of a complex composed of FtsB, FtsL and FtsQ.
Gallibacterium anatis SV200 strain a non-biofilm producer.
Complete Genome Sequence of the Alcanivorax N3-7A, isolated from petroleum hydrocarbon contaminated shoreline Newfoundland, Canada.
Belongs to the FtsK/SpoIIIE/SftA family.
Dipeptide ABC transporter ATP-binding protein
Dipeptide ABC transporter ATP-binding subunit DppF
Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.
Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE
Belongs to the glutamate 5-kinase family.
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
Belongs to the glycosyl hydrolase 65 family.
Sigma-54-dependent Fis family transcriptional regulator
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
Belongs to the bacterial flagellin family.
Multidrug resistance outer membrane protein MdtQ
Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
Belongs to the anhydro-N-acetylmuramic acid kinase family.
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
Binds 2 Mg(2+) per subunit. Only one magnesium ion has a direct interaction with the protein, the other interactions are indirect.
Binds 1 K(+) per subunit. The potassium ion strongly increases the affinity for DNA.
Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
Photobacterium damselae subsp. damselae comparative genomics.
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
Belongs to the methylthiotransferase family. RimO subfamily.
Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase
Ribosomal protein S12 methylthiotransferase RimO
Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation.
The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.
Cross-interface Injection: A General Nanoliter Liquid Handling Method Applied to Single Cells Genome Amplification Automated Nanoliter Liquid Handling Applied to Single Cell Multiple Displacement Amplification.
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.
Belongs to the ABC transporter superfamily.
Glutamate/aspartate transport ATP-binding protein GltL
Glutamate/aspartate ABC transporter ATP binding protein GltL
Glyceraldehyde-3-phosphate dehydrogenase
Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
Nitrogen assimilation regulatory protein
Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
LuxR family transcriptional regulator, maltose regulon positive regulatory protein
Membrane protein involved in F pilin formation.
Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
Homodimer. Part of the PDH complex, consisting of multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
Small-conductance mechanosensitive channel
Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell, opening in response to stretch forces in the membrane lipid bilayer, without the need for other proteins. Contributes to normal resistance to hypoosmotic shock. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions.
Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5-phosphonooxypentane-2,4-dione (P-HPD).
(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase
Phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerase
Involved in the regulation of ptsG expression by binding and inactivating Mlc.
Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB.
The accessory proteins ExbB and ExbD seem to form a complex with TonB.
Rsx electron transport complex subunit C
Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
Ion-translocating oxidoreductase complex subunit C
Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
Ribosomal RNA small subunit methyltransferase G
16S rRNA 7-methylguanosine methyltransferase
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
Pyridoxal phosphate-dependent aminotransferase
Belongs to the acetolactate synthase small subunit family.
Acetohydroxy-acid synthase small subunit
Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
Belongs to the acyl carrier protein (ACP) family.
4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
Tyr recombinase domain-containing protein
ATP-dependent Clp protease ATP-binding subunit ClpA
Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
Plays an important role in discriminating NADH against NADPH
Enoyl-[acyl-carrier-protein] reductase [NADH]
Two-component system response regulator NarL
Subunit R is required for both nuclease and ATPase activities, but not for modification.
The type I restriction/modification system is composed of three polypeptides R, M and S.
Type I restriction enzyme endonuclease subunit
Methyl-accepting chemotaxis citrate transducer
Belongs to the methyl-accepting chemotaxis (MCP) protein family.
Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP.
Belongs to the acetokinase family. TdcD subfamily.
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
Belongs to the AB hydrolase superfamily. MetX family.
The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
Molybdopterin-guanine dinucleotide synthase
Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.
Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
Comprises two domains: an N-terminal domain containing the nucleotidyltransferase activity and a C-terminal HD domain associated with both phosphodiesterase and phosphatase activities.
A single active site specifically recognizes both ATP and CTP and is responsible for their addition.
Monomer. Can also form homodimers and oligomers.
Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Bacterial CCA-adding enzyme type 1 subfamily.
Magnesium is required for nucleotidyltransferase activity.
Site-specific DNA-methyltransferase (adenine-specific)
Spermidine/putrescine import ATP-binding protein PotA
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD).
Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
DNA-dependent ATPase and 5'-3' DNA helicase.
Belongs to the helicase family. DinG subfamily. Type 1 sub-subfamily.
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.
Glutamate synthase (NADPH) small subunit
Acinetobactin export ABC transporter permease/ATP-binding subunit BarB
Catalyzes the strictly specific dephosphorylation of 2'-deoxyribonucleoside 5'-monophosphates.
Appears to be important in orienting the phosphate for catalysis
Nucleoside 5'-monophosphate phosphohydrolase
Colanic acid capsular biosynthesis activation protein A
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
Methylated by PrmC. Methylation increases the termination efficiency of RF1.
Belongs to the prokaryotic/mitochondrial release factor family.
Belongs to the universal ribosomal protein uS10 family.
Involved in the binding of tRNA to the ribosomes.
TetR/AcrR family transcriptional regulator
Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1->4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.
Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.
(1->4)-alpha-D-glucan:maltose-1-phosphate alpha-D-maltosyltransferase
Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
Homodimer, forms a heterotetramer with a Cas1 homodimer.
Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.
4-hydroxy-tetrahydrodipicolinate reductase
(S)-2,3,4,5-tetrahydrodipicolinate binding
Belongs to the glutamate synthase family.
Belongs to the aldehyde dehydrogenase family.
L-glutamate gamma-semialdehyde dehydrogenase
Delta-1-pyrroline-5-carboxylate dehydrogenase
Oxidizes proline to glutamate for use as a carbon and nitrogen source.
In the N-terminal section; belongs to the proline dehydrogenase family.
In the C-terminal section; belongs to the aldehyde dehydrogenase family.
Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.
Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
Sulfur carrier protein ThiS sulfurtransferase
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
Belongs to the universal ribosomal protein uL5 family.
Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
Belongs to the DNA photolyase class-1 family.
The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.
3-oxoacyl-[acyl-carrier-protein] synthase 3
Belongs to the thiolase-like superfamily. FabH family.
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
3-oxoacyl-[acyl-carrier-protein] synthase III
FMN-dependent NADH-azo compound oxidoreductase
Quinone reductase that provides resistance to thiol-specific stress caused by electrophilic quinones.
FMN dependent NADH:quinone oxidoreductase
Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
Belongs to the azoreductase type 1 family.
Putative ABC transporter ATP-binding protein YbbL
Belongs to the anthranilate phosphoribosyltransferase family.
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.
Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
Putative periplasmic carboxyl-terminal protease
C-terminal processing peptidase family protein
Periplasmic serine proteases (ClpP class)
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
Interaction with tRNA. Important for base-flipping
Belongs to the tRNA pseudouridine synthase TruA family.
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Interaction with tRNA; Important for base-flipping
Undecaprenyl-phosphate Ara4FN transferase
Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase
Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
Belongs to the glycosyltransferase 2 family.
Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
blaNDM-1 context 1 from Acinetobacter baumannii CHI-45-1.
Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
blaNDM-1 context 2 from Acinetobacter baumannii CHI-45-1.
The genetic characterization of NDM-1 producing Enterobacteriaceae and Acinetobacter baumannii from Pakistan hospitals for an insight of blaNDM acquisition via plasmids.
Type II secretion system is composed of four main components: the outer membrane complex, the inner membrane complex, the cytoplasmic secretion ATPase and the periplasm-spanning pseudopilus. Forms homomultimers.
The active site is a redox-active disulfide bond.
Interacts with FtsZ via their C-terminal domains.
Localizes to the Z ring in an FtsZ-dependent manner.
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.
Belongs to the PEP-utilizing enzyme family.
Phosphoenolpyruvate--protein phosphotransferase
A Seawater Based Open and Continuous Process for Polyhydroxyalkanoates Production by Recombinant Halomonas campaniensis LS21 Grown in Mixed Substrates.
Assembles at midcell at the inner surface of the cytoplasmic membrane.
Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Belongs to the radical SAM superfamily. Lipoyl synthase family.
Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
Catalyzes the reversible epimerization at C-2 of UDP-N-acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues.
Belongs to the UDP-N-acetylglucosamine 2-epimerase family.
Belongs to the leucine-binding protein family.
L-leucine-binding protein /L-isoleucine-binding protein /L-valine-binding protein
Branched-chain amino acid ABC transporter substrate-binding protein
Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.
4-hydroxy-tetrahydrodipicolinate synthase
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
Translesion error-prone DNA polymerase V subunit UmuC
Belongs to the DNA polymerase type-Y family.
Belongs to the complex I 24 kDa subunit family.
Arabinose operon transcriptional regulator AraC
Complete genomic analysis of a Citrobacter pasteurii isolated from cockles (Cerastoderma edule) containing a new chromosomic qnrB allele.
Imidazole glycerol phosphate synthase subunit HisF
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.
Catalyzes the oxidation of L-aspartate to iminoaspartate.
Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.
sn-glycerol-3-phosphate transport system permease protein UgpE
Belongs to the binding-protein-dependent transport system permease family. UgpAE subfamily.
The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB).
Putative MFS transporter, AGZA family, xanthine/uracil permease
Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
Winged helix-turn-helix domain-containing protein
Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the genomes of soil and plant-associated and newly described type strains.
Comparative analysis of microorganisms from saline springs in Andes Mountain Range, Colombia.
Guanosine 5'-monophosphate oxidoreductase
Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.
Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
Sensor domain-containing diguanylate cyclase
Multidrug efflux RND transporter periplasmic adaptor subunit AdeA
Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
Protein-glutamine N-methyltransferase PrmC
Release factor glutamine methyltransferase
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.
Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
Magnesium transporter CorA family protein
Belongs to the FAD-dependent oxidoreductase family.
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Rhomboid family intramembrane serine protease
Belongs to the type IA topoisomerase family.
O-(5'-phospho-DNA)-tyrosine intermediate
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
Belongs to the class-I aminoacyl-tRNA synthetase family.
Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin.
Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
Belongs to the vitamin-B12 dependent methionine synthase family.
5-methyltetrahydrofolate--homocysteine methyltransferase
Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
Acetyl-CoA carboxylase carboxyltransferase subunit beta
Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
Uncharacterized conserved protein (DUF2132)
Glycerol 3-phosphate ABC transporter membrane protein
Glycerol-3-phosphate transporter permease
sn-glycerol-3-phosphate transport system permease protein ugpA
sn-glycerol-3-phosphate ABC transporter permease UgpA
Chemotaxis protein histidine kinase and related kinase
Gamma-glutamylcyclotransferase family protein ytfP
Gamma-glutamylcyclotransferase (GGCT)/AIG2-like uncharacterized protein YtfP
Belongs to the bacterial ribosomal protein bS16 family.
Belongs to the metallophosphoesterase superfamily. YfcE family.
Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
Type III secretion system translocon protein SseD
Pathogenicity island 2 effector protein SseD
SPI-2 type III secretion system translocon protein SseD
AbrB/MazE/SpoVT family DNA-binding domain-containing protein
Belongs to the RNA methyltransferase TrmD family.
Specifically methylates guanosine-37 in various tRNAs.
Poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA
Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.
Interacts with tRNA; defines subfamily-specific binding signature
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs.
Belongs to the Dus family. DusC subfamily.
Type III secretion system needle tip protein SipD
Belongs to the invasin protein D family.
Binds 1 divalent metal cation per subunit.
Belongs to the metallo-dependent hydrolases superfamily. NagA family.
N-acetylglucosamine-6-phosphate deacetylase
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
4-methyl-5-beta-hydroxyethylthiazole kinase
Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
Galactose-1-phosphate uridylyltransferase
UDP-alpha-D-glucose binding; shared with dimeric partner
Superoxide response transcriptional regulator SoxS
Putative tetracyline resistance transcriptional regulator TetC
Tetracyline resistance-associated transcriptional repressor TetC
4-CDP-2-C-methyl-D-erythritol 2-phosphate binding
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Belongs to the topoisomerase GyrA/ParC subunit family.
Belongs to the type II topoisomerase GyrA/ParC subunit family.
Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.
Belongs to the type III secretion exporter family.
Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.
Putative alkylphosphonate uptake protein in phosphonate metabolism
Ribosomal RNA small subunit methyltransferase C
Belongs to the methyltransferase superfamily. RsmC family.
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
rRNA (guanine-N(2)-)-methyltransferase RsmC
Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily.
Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response.
Voltage-gated ClC-type chloride channel ClcB
Localizes to the septum. Localizes to the midcell via interaction with the early cell division protein FtsA and via the periplasmic SPOR domain.
Interacts with FtsA via its N-terminal cytoplasmic domain.
Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases.
Belongs to the triosephosphate isomerase family.
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Belongs to the pseudouridine synthase RluA family.
Responsible for synthesis of pseudouridine from uracil.
Metagenomic reconstruction reveals the metabolic diversity of the novel genus Ketobacter and the trajectory of genomic evolution within the Alcanivoraceae family.
Plays a role in the flagellum-specific transport system.
In the N-terminal section; belongs to the UvrB family.
Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
In the C-terminal section; belongs to the helicase family. RecG subfamily.
The Rieske protein is a high potential 2Fe-2S protein.
Belongs to the Rieske iron-sulfur protein family.
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.
Ubiquinol-cytochrome c reductase iron-sulfur subunit
The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.
Multisubunit Na+/H+ antiporter subunit E
Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.
Hybrid-cluster NAD(P)-dependent oxidoreductase
Belongs to the EcnA/EcnB lipoprotein family.
Belongs to the ABC-2 integral membrane protein family.
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.
Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.
Serine phosphatase RsbU, regulator of sigma subunit
X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 25-394
2.60 Angstrom Resolution Crystal Structure of Peptidase S41 from Acinetobacter baumannii.
Center for Structural Genomics of Infectious Diseases (CSGID)
Formate/nitrite transporter family protein
Efflux transporter, outer membrane factor (OMF) lipo, NodT family protein
AdeC/AdeK/OprM family multidrug efflux complex outer membrane factor
Putative siderophore biosynthesis protein
Belongs to the glycosyl hydrolase 8 (cellulase D) family.
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme
Phosphoribosyl-aminoimidazole synthetase
Phosphoribosylformylglycinamidine cyclo-ligase
Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.
Aminodeoxychorismate/anthranilate synthase component II
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.
Vitamin B12 import ATP-binding protein BtuD
Belongs to the ABC transporter superfamily. Vitamin B12 importer (TC 3.A.1.13.1) family.
The complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
L-glutamine--D-fructose-6-phosphate amidotransferase
Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
Sugar ABC transporter ATP-binding protein
During stationary phase, binds the chromosome non-specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction.
Homododecamer. The 12 subunits form a hollow sphere into which the mineral iron core of up to 500 Fe(3+) can be deposited.
DNA protection during starvation protein
Outer membrane protein assembly factor BamD
Part of the Bam complex, which is composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE.
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery.
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Glutathionylspermidine synthase family protein
ATP-dependent Clp protease ATP-binding subunit ClpX
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.
Belongs to the cyclophilin-type PPIase family.
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Phage shock protein operon transcriptional activator
Pyridoxine/pyridoxamine 5'-phosphate oxidase
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
Belongs to the pyridoxamine 5'-phosphate oxidase family.
Branched-chain-amino-acid aminotransferase
Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.
In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.
Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
Microcin C ABC transporter ATP-binding protein YejF
The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers.
Formate dehydrogenase iron-sulfur subunit
PTS system glucose-specific transporter subunit IICBA
Belongs to the argininosuccinate synthase family. Type 2 subfamily.
May be involved in recombinational repair of damaged DNA.
AGZA family xanthine/uracil permease-like MFS transporter
Stress-induced bacterial acidophilic repeat motif
TIGR03750 family conjugal transfer protein
Outer-membrane lipoprotein carrier protein
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
tRNA 5-hydroxyuridine modification protein YegQ
TPR repeat-containing SEL1 subfamily protein
This protein is an aporepressor. When complexed with L-tryptophan it binds the operator region of the trp operon (5'-ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region.
ABC-F family ATP-binding cassette domain-containing protein
ATP-binding cassette domain-containing protein
PTS system glucose-specific EIICB component
Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.
Membrane-bound lytic murein transglycosylase A
Zn-dependent protease with chaperone function
Phenylalanyl-tRNA synthetase alpha subunit
Tetramer of two alpha and two beta subunits.
Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
Phenylalanine--tRNA ligase alpha subunit
May function as a transcriptional regulator that controls feoABC expression.
Probable [Fe-S]-dependent transcriptional repressor
Alpha-keto acid decarboxylase family protein
Binds 2 divalent metal cations per subunit.
Belongs to the class-II aminoacyl-tRNA synthetase family.
Component of an export pathway for enterobactin.
Belongs to the major facilitator superfamily. EntS (TC 2.A.1.38) family.
IS6-like element IS6100 family transposase
5-phospho-alpha-D-ribose 1-diphosphate binding
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.
Xanthine dehydrogenase FAD-binding subunit
In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
Single-chain monomer with multiple functions.
Belongs to the DNA polymerase type-A family.
Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
Chromosomal replication initiator protein DnaA
DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.
Replication-associated recombination protein A
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
Belongs to the bacterial ribosomal protein bL12 family.
Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
Phosphoesterase PA-phosphatase-like protein
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
NDH-1 is composed of 13 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
Belongs to the complex I subunit 3 family.
A non-essential division protein that localizes to the septal ring in low ionic strength medium.
Localizes to the septal ring before constriction, only when cells are grown at low ionic strength.
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
UDP-N-acetylmuramoylalanine--D-glutamate ligase
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Acyl-[acyl-carrier-protein]--phosphate acyltransferase
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
Homodimer. Probably interacts with PlsY.
Associated with the membrane possibly through PlsY.
Belongs to the bacterial glucokinase family.
Belongs to the dethiobiotin synthetase family.
ATP-dependent dethiobiotin synthetase BioD
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
Belongs to the ABC1 family. UbiB subfamily.
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
Phenotypic and genotypic richness of denitrifiers revealed by a novel isolation strategy.
Ribosome-associated translation inhibitor RaiA
Belongs to the glycosyl hydrolase 37 family.
Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.
Periplasmic serine endoprotease DegP-like
Cystine ABC-type transport system, ATP-binding protein
Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PSRP subfamily.
Phosphoenolpyruvate synthase regulatory protein
Pyruvate, water dikinase regulatory protein
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
Homoserine/threonine efflux family protein
Oligomer with a subunit composition of (alpha,beta,gamma)6.
Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit subfamily.
Two pore domain potassium channel family protein
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
1-acyl-sn-glycerol-3-phosphate acyltransferase
Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
Holliday junction ATP-dependent DNA helicase RuvA
2 residues (Tyr-90 and Arg-93) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.
NAD-dependent lysine deacetylase that specifically removes acetyl groups on target proteins. Also acts as a protein-lysine deacylase by mediating protein desuccinylation and de-2-hydroxyisobutyrylation. Modulates the activities of several proteins which are inactive in their acylated form.
Belongs to the sirtuin family. Class III subfamily.
Catalyzes both the uptake and excretion of putrescine. The uptake of putrescine is dependent on the membrane potential and the excretion involves putrescine-ornithine antiporter activity.
Putrescine-proton symporter / putrescine-ornithine antiporter
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.
Localizes to the septum at mid-cell, in a FtsZ-like pattern.
Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA.
Homodimer. The ends of the coiled-coil dimer bind to each other, forming polymers. Interacts with FtsZ.
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
Sec-independent protein translocase protein TatB
Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
ATP adenosine-5'-phosphosulfate 3'-phosphotransferase
Catalyzes the synthesis of activated sulfate.
DeoR/GlpR family DNA-binding transcription regulator
In the N-terminal section; belongs to the DHBP synthase family.
In the C-terminal section; belongs to the GTP cyclohydrolase II family.
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
ATP:glutamine synthetase adenylyltransferase
Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme
Glutamine synthetase adenylyl-L-tyrosine phosphorylase
Glutamine synthetase adenylyl transferase
Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
Localizes to mid-cell in an FtsZ-dependent manner.