Q8HMR2
type: Protein
reviewed: false
created: 2003-03-01
modified: 2022-12-14
version: 65
mnemonic: Q8HMR2_POLSE
citation: http://purl.uniprot.org/citations/12470943
recommended name: SIP7BF6D4C4FDB5C391
enzyme: http://purl.uniprot.org/enzyme/7.1.1.2
organism: http://purl.uniprot.org/taxonomy/178879
encoded in: Mitochondrion
annotation: SIPAFD081BEA018E452
annotation: SIP44DE13853E0B0D7E
annotation: SIP47A69B5DA7EB5499
annotation: SIP98AC72C10DCFB592
annotation: SIP3CDA8142F9C4B982
annotation: PRO_5004309280
annotation: SIP0DF2F63E15E5C196
annotation: SIP1BC6406C7BE8513B
annotation: SIPFCB18E55973AA3A1
annotation: SIP3B50C0BE7915254D
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/496
classified with: http://purl.uniprot.org/keywords/520
classified with: http://purl.uniprot.org/keywords/679
classified with: http://purl.uniprot.org/keywords/732
classified with: http://purl.uniprot.org/keywords/1278
classified with: http://purl.uniprot.org/keywords/1133
classified with: http://purl.uniprot.org/keywords/830
classified with: GO_0031966
classified with: GO_0070469
classified with: GO_0008137
sequence: MVLMVVFSVIFLVSLIAVASNPSPYFAAFGLMVGAGVGCGMLMQCGMTFLSVILFLIYLGGMLVVFAYSAALAAEPYPPAWGSWEVFSYVLGYMVLVIMVWAVFVGDFGVLDDIEGHFGAVRRYVGVAEVYNVGGYMLLVAGWVLLMALLVVLELTRGYSRGCLRAV

http://purl.uniprot.org/citations/12470943
type: Journal Citation
title: Basal actinopterygian relationships: a mitogenomic perspective on the phylogeny of the 'ancient fish.'.
author: Inoue J.
author: Miya M.
author: Tsukamoto K.
author: Nishida M.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/12470943
date: 2003
name: Mol. Phylogenet. Evol.
volume: 26
pages: 110-120

Q8HMR2-citation-12470943
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

IPR001457
type: Resource
database: InterPro
comment: NADH_UbQ/plastoQ_OxRdtase_su6

IPR042106
type: Resource
database: InterPro
comment: Nuo/plastoQ_OxRdtase_6_NuoJ

PF00499
type: Resource
database: Pfam
comment: Oxidored_q3
signature sequence match: Pfam PF00499 match 1

SIP7BF6D4C4FDB5C391
type: Structured Name
full name: NADH-ubiquinone oxidoreductase chain 6
ec name: 7.1.1.2

ND6
type: Gene

SIPAFD081BEA018E452
type: Function Annotation
comment: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

SIP98AC72C10DCFB592
type: Similarity Annotation
comment: Belongs to the complex I subunit 6 family.

22861356299596334tt1
type: Position
type: ExactPosition
position: 1
reference: MVLMVVFSVIFLVSLIAVASNPSPYFAAFGLMVGAGVGCGMLMQCGMTFLSVILFLIYLGGMLVVFAYSAALAAEPYPPAWGSWEVFSYVLGYMVLVIMVWAVFVGDFGVLDDIEGHFGAVRRYVGVAEVYNVGGYMLLVAGWVLLMALLVVLELTRGYSRGCLRAV

22861356299596334tt19
type: Position
type: ExactPosition
position: 19
reference: MVLMVVFSVIFLVSLIAVASNPSPYFAAFGLMVGAGVGCGMLMQCGMTFLSVILFLIYLGGMLVVFAYSAALAAEPYPPAWGSWEVFSYVLGYMVLVIMVWAVFVGDFGVLDDIEGHFGAVRRYVGVAEVYNVGGYMLLVAGWVLLMALLVVLELTRGYSRGCLRAV

PRO_5004309280
type: Chain Annotation
comment: NADH-ubiquinone oxidoreductase chain 6
mass: 15975
range: 22861356299596334tt20tt167

22861356299596334tt20
type: Position
type: ExactPosition
position: 20
reference: MVLMVVFSVIFLVSLIAVASNPSPYFAAFGLMVGAGVGCGMLMQCGMTFLSVILFLIYLGGMLVVFAYSAALAAEPYPPAWGSWEVFSYVLGYMVLVIMVWAVFVGDFGVLDDIEGHFGAVRRYVGVAEVYNVGGYMLLVAGWVLLMALLVVLELTRGYSRGCLRAV

22861356299596334tt167
type: Position
type: ExactPosition
position: 167
reference: MVLMVVFSVIFLVSLIAVASNPSPYFAAFGLMVGAGVGCGMLMQCGMTFLSVILFLIYLGGMLVVFAYSAALAAEPYPPAWGSWEVFSYVLGYMVLVIMVWAVFVGDFGVLDDIEGHFGAVRRYVGVAEVYNVGGYMLLVAGWVLLMALLVVLELTRGYSRGCLRAV

SIP0DF2F63E15E5C196
type: Transmembrane Annotation
comment: Helical
range: 22861356299596334tt27tt45

22861356299596334tt27
type: Position
type: ExactPosition
position: 27
reference: MVLMVVFSVIFLVSLIAVASNPSPYFAAFGLMVGAGVGCGMLMQCGMTFLSVILFLIYLGGMLVVFAYSAALAAEPYPPAWGSWEVFSYVLGYMVLVIMVWAVFVGDFGVLDDIEGHFGAVRRYVGVAEVYNVGGYMLLVAGWVLLMALLVVLELTRGYSRGCLRAV

22861356299596334tt45
type: Position
type: ExactPosition
position: 45
reference: MVLMVVFSVIFLVSLIAVASNPSPYFAAFGLMVGAGVGCGMLMQCGMTFLSVILFLIYLGGMLVVFAYSAALAAEPYPPAWGSWEVFSYVLGYMVLVIMVWAVFVGDFGVLDDIEGHFGAVRRYVGVAEVYNVGGYMLLVAGWVLLMALLVVLELTRGYSRGCLRAV

SIP1BC6406C7BE8513B
type: Transmembrane Annotation
comment: Helical
range: 22861356299596334tt52tt74

22861356299596334tt52
type: Position
type: ExactPosition
position: 52
reference: MVLMVVFSVIFLVSLIAVASNPSPYFAAFGLMVGAGVGCGMLMQCGMTFLSVILFLIYLGGMLVVFAYSAALAAEPYPPAWGSWEVFSYVLGYMVLVIMVWAVFVGDFGVLDDIEGHFGAVRRYVGVAEVYNVGGYMLLVAGWVLLMALLVVLELTRGYSRGCLRAV

22861356299596334tt74
type: Position
type: ExactPosition
position: 74
reference: MVLMVVFSVIFLVSLIAVASNPSPYFAAFGLMVGAGVGCGMLMQCGMTFLSVILFLIYLGGMLVVFAYSAALAAEPYPPAWGSWEVFSYVLGYMVLVIMVWAVFVGDFGVLDDIEGHFGAVRRYVGVAEVYNVGGYMLLVAGWVLLMALLVVLELTRGYSRGCLRAV

SIPFCB18E55973AA3A1
type: Transmembrane Annotation
comment: Helical
range: 22861356299596334tt86tt110

22861356299596334tt86
type: Position
type: ExactPosition
position: 86
reference: MVLMVVFSVIFLVSLIAVASNPSPYFAAFGLMVGAGVGCGMLMQCGMTFLSVILFLIYLGGMLVVFAYSAALAAEPYPPAWGSWEVFSYVLGYMVLVIMVWAVFVGDFGVLDDIEGHFGAVRRYVGVAEVYNVGGYMLLVAGWVLLMALLVVLELTRGYSRGCLRAV

22861356299596334tt110
type: Position
type: ExactPosition
position: 110
reference: MVLMVVFSVIFLVSLIAVASNPSPYFAAFGLMVGAGVGCGMLMQCGMTFLSVILFLIYLGGMLVVFAYSAALAAEPYPPAWGSWEVFSYVLGYMVLVIMVWAVFVGDFGVLDDIEGHFGAVRRYVGVAEVYNVGGYMLLVAGWVLLMALLVVLELTRGYSRGCLRAV

SIP3B50C0BE7915254D
type: Transmembrane Annotation
comment: Helical
range: 22861356299596334tt130tt152

22861356299596334tt130
type: Position
type: ExactPosition
position: 130
reference: MVLMVVFSVIFLVSLIAVASNPSPYFAAFGLMVGAGVGCGMLMQCGMTFLSVILFLIYLGGMLVVFAYSAALAAEPYPPAWGSWEVFSYVLGYMVLVIMVWAVFVGDFGVLDDIEGHFGAVRRYVGVAEVYNVGGYMLLVAGWVLLMALLVVLELTRGYSRGCLRAV

22861356299596334tt152
type: Position
type: ExactPosition
position: 152
reference: MVLMVVFSVIFLVSLIAVASNPSPYFAAFGLMVGAGVGCGMLMQCGMTFLSVILFLIYLGGMLVVFAYSAALAAEPYPPAWGSWEVFSYVLGYMVLVIMVWAVFVGDFGVLDDIEGHFGAVRRYVGVAEVYNVGGYMLLVAGWVLLMALLVVLELTRGYSRGCLRAV

MVLMVVFSVIFLVSLIAVASNPSPYFAAFGLMVGAGVGCGMLMQCGMTFLSVILFLIYLGGMLVVFAYSAALAAEPYPPAWGSWEVFSYVLGYMVLVIMVWAVFVGDFGVLDDIEGHFGAVRRYVGVAEVYNVGGYMLLVAGWVLLMALLVVLELTRGYSRGCLRAV
type: Simple Sequence
modified: 2003-03-01
version: 1
mass: 18009

Q8HMR9
type: Protein
reviewed: false
created: 2003-03-01
modified: 2022-12-14
version: 76
mnemonic: Q8HMR9_POLSE
citation: http://purl.uniprot.org/citations/12470943
recommended name: SIP1E250F07EB44E932
organism: http://purl.uniprot.org/taxonomy/178879
encoded in: Mitochondrion
annotation: SIP760821C94AAF3D94
annotation: SIPD024838B2CE9B407
annotation: SIP513032820023D488
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/66
classified with: http://purl.uniprot.org/keywords/138
classified with: http://purl.uniprot.org/keywords/496
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0000276
classified with: GO_0015078
classified with: GO_0015986
sequence: MPQLNPDPWFIILIFTWTVFLTILPNKVIMHKTPNEPLTKDPSSLLTEIWSWPWH

Q8HMR9-citation-12470943
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

IPR001421
type: Resource
database: InterPro
comment: ATP8_metazoa

PF00895
type: Resource
database: Pfam
comment: ATP-synt_8
signature sequence match: Pfam PF00895 match 1

SIP1E250F07EB44E932
type: Structured Name
full name: ATP synthase protein 8

ATP8
type: Gene

SIPD024838B2CE9B407
type: Similarity Annotation
comment: Belongs to the ATPase protein 8 family.

SIP513032820023D488
type: Transmembrane Annotation
comment: Helical
range: 22861356299598126tt6tt24

22861356299598126tt6
type: Position
type: ExactPosition
position: 6
reference: MPQLNPDPWFIILIFTWTVFLTILPNKVIMHKTPNEPLTKDPSSLLTEIWSWPWH

22861356299598126tt24
type: Position
type: ExactPosition
position: 24
reference: MPQLNPDPWFIILIFTWTVFLTILPNKVIMHKTPNEPLTKDPSSLLTEIWSWPWH

MPQLNPDPWFIILIFTWTVFLTILPNKVIMHKTPNEPLTKDPSSLLTEIWSWPWH
type: Simple Sequence
modified: 2003-03-01
version: 1
mass: 6585

Q8HMR4
type: Protein
reviewed: false
created: 2003-03-01
modified: 2022-12-14
version: 95
mnemonic: Q8HMR4_POLSE
citation: http://purl.uniprot.org/citations/12470943
recommended name: SIP35FCC5F74834FC6E
enzyme: http://purl.uniprot.org/enzyme/7.1.1.2
organism: http://purl.uniprot.org/taxonomy/178879
encoded in: Mitochondrion
annotation: SIPE369B446C9DD782B
annotation: SIP62AD51FE4531CD73
annotation: SIP87CF54B7A8DE5C03
annotation: SIP6A039F5F7A18123C
annotation: SIP973D4191D58820CA
annotation: SIP07EAD8B2FC268A0A
annotation: SIP7AFAF5EE493B8F38
annotation: SIP12FAD191C2EA272B
annotation: SIP8B8F44A9A31AA815
annotation: SIP8B799A8E76763309
annotation: SIP6611670F88C748BC
annotation: SIPCCFE27C23E093A7A
annotation: SIP5BDF7B7C59550986
annotation: SIP6CB5763E4BFDD7F5
annotation: SIPCE6F2D711A7191B2
annotation: SIP5B2A0D7708023D24
annotation: SIP67BF6179D1466B88
annotation: SIP6CA1964B63C699AE
annotation: SIPD001956AF87B3494
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/496
classified with: http://purl.uniprot.org/keywords/520
classified with: http://purl.uniprot.org/keywords/679
classified with: http://purl.uniprot.org/keywords/1133
classified with: http://purl.uniprot.org/keywords/830
classified with: GO_0031966
classified with: GO_0070469
classified with: GO_0008137
classified with: GO_0042773
sequence: Q8HMR4-1

Q8HMR4-citation-12470943
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

IPR000260
type: Resource
database: InterPro
comment: NADH4_N

IPR010227
type: Resource
database: InterPro
comment: NADH_Q_OxRdtase_chainM/4

IPR003918
type: Resource
database: InterPro
comment: NADH_UbQ_OxRdtase

IPR001750
type: Resource
database: InterPro
comment: ND/Mrp_mem

PTHR43507
type: Resource
database: PANTHER
comment: NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4
signature sequence match: PANTHER PTHR43507 match 1

PF01059
type: Resource
database: Pfam
comment: Oxidored_q5_N
signature sequence match: Pfam PF01059 match 1

PF00361
type: Resource
database: Pfam
comment: Proton_antipo_M
signature sequence match: Pfam PF00361 match 1

PR01437
type: Resource
database: PRINTS
comment: NUOXDRDTASE4

TIGR01972
type: Resource
database: TIGRFAMs
comment: NDH_I_M
signature sequence match: TIGRFAMs TIGR01972 match 1

SIP35FCC5F74834FC6E
type: Structured Name
full name: NADH-ubiquinone oxidoreductase chain 4
ec name: 7.1.1.2

ND4
type: Gene

SIPE369B446C9DD782B
type: Function Annotation
comment: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

SIP6A039F5F7A18123C
type: Similarity Annotation
comment: Belongs to the complex I subunit 4 family.

SIP973D4191D58820CA
type: Transmembrane Annotation
comment: Helical
range: 22861356299596846tt21tt42

22861356299596846tt21
type: Position
type: ExactPosition
position: 21
reference: Q8HMR4-1

22861356299596846tt42
type: Position
type: ExactPosition
position: 42
reference: Q8HMR4-1

SIP07EAD8B2FC268A0A
type: Transmembrane Annotation
comment: Helical
range: 22861356299596846tt62tt81

22861356299596846tt62
type: Position
type: ExactPosition
position: 62
reference: Q8HMR4-1

22861356299596846tt81
type: Position
type: ExactPosition
position: 81
reference: Q8HMR4-1

SIP7AFAF5EE493B8F38
type: Transmembrane Annotation
comment: Helical
range: 22861356299596846tt93tt111

22861356299596846tt93
type: Position
type: ExactPosition
position: 93
reference: Q8HMR4-1

22861356299596846tt111
type: Position
type: ExactPosition
position: 111
reference: Q8HMR4-1

SIP12FAD191C2EA272B
type: Transmembrane Annotation
comment: Helical
range: 22861356299596846tt117tt138

22861356299596846tt117
type: Position
type: ExactPosition
position: 117
reference: Q8HMR4-1

22861356299596846tt138
type: Position
type: ExactPosition
position: 138
reference: Q8HMR4-1

SIP8B8F44A9A31AA815
type: Transmembrane Annotation
comment: Helical
range: 22861356299596846tt150tt169

22861356299596846tt150
type: Position
type: ExactPosition
position: 150
reference: Q8HMR4-1

22861356299596846tt169
type: Position
type: ExactPosition
position: 169
reference: Q8HMR4-1

SIP8B799A8E76763309
type: Transmembrane Annotation
comment: Helical
range: 22861356299596846tt189tt209

22861356299596846tt189
type: Position
type: ExactPosition
position: 189
reference: Q8HMR4-1

22861356299596846tt209
type: Position
type: ExactPosition
position: 209
reference: Q8HMR4-1

SIP6611670F88C748BC
type: Transmembrane Annotation
comment: Helical
range: 22861356299596846tt221tt244

22861356299596846tt221
type: Position
type: ExactPosition
position: 221
reference: Q8HMR4-1

22861356299596846tt244
type: Position
type: ExactPosition
position: 244
reference: Q8HMR4-1

SIPCCFE27C23E093A7A
type: Transmembrane Annotation
comment: Helical
range: 22861356299596846tt256tt273

22861356299596846tt256
type: Position
type: ExactPosition
position: 256
reference: Q8HMR4-1

22861356299596846tt273
type: Position
type: ExactPosition
position: 273
reference: Q8HMR4-1

SIP5BDF7B7C59550986
type: Transmembrane Annotation
comment: Helical
range: 22861356299596846tt285tt303

22861356299596846tt285
type: Position
type: ExactPosition
position: 285
reference: Q8HMR4-1

22861356299596846tt303
type: Position
type: ExactPosition
position: 303
reference: Q8HMR4-1

SIP6CB5763E4BFDD7F5
type: Transmembrane Annotation
comment: Helical
range: 22861356299596846tt309tt329

22861356299596846tt309
type: Position
type: ExactPosition
position: 309
reference: Q8HMR4-1

22861356299596846tt329
type: Position
type: ExactPosition
position: 329
reference: Q8HMR4-1

SIPCE6F2D711A7191B2
type: Transmembrane Annotation
comment: Helical
range: 22861356299596846tt350tt369

22861356299596846tt350
type: Position
type: ExactPosition
position: 350
reference: Q8HMR4-1

22861356299596846tt369
type: Position
type: ExactPosition
position: 369
reference: Q8HMR4-1

SIP5B2A0D7708023D24
type: Transmembrane Annotation
comment: Helical
range: 22861356299596846tt389tt412

22861356299596846tt389
type: Position
type: ExactPosition
position: 389
reference: Q8HMR4-1

22861356299596846tt412
type: Position
type: ExactPosition
position: 412
reference: Q8HMR4-1

SIP67BF6179D1466B88
type: Transmembrane Annotation
comment: Helical
range: 22861356299596846tt433tt456

22861356299596846tt433
type: Position
type: ExactPosition
position: 433
reference: Q8HMR4-1

22861356299596846tt456
type: Position
type: ExactPosition
position: 456
reference: Q8HMR4-1

SIP6CA1964B63C699AE
type: Domain Extent Annotation
comment: Oxidored_q5_N
range: 22861356299596846tt1tt110

22861356299596846tt1
type: Position
type: ExactPosition
position: 1
reference: Q8HMR4-1

22861356299596846tt110
type: Position
type: ExactPosition
position: 110
reference: Q8HMR4-1

SIPD001956AF87B3494
type: Domain Extent Annotation
comment: Proton_antipo_M
range: 22861356299596846tt113tt403

22861356299596846tt113
type: Position
type: ExactPosition
position: 113
reference: Q8HMR4-1

22861356299596846tt403
type: Position
type: ExactPosition
position: 403
reference: Q8HMR4-1

Q8HMR4-1
type: Simple Sequence
modified: 2003-03-01
version: 1
mass: 51245
value: MLKLLIPTIMLFPTIWVLSPKWLWSITTAHSLMIATLSLTLFKYYSTTPWSNLNYMMATDMISTPLIVLTCWLLPLMILASQNHISPEPINRQRSYITLLVSLQTLLIMAFSATEIILFYIMFEATLIPTLIIITRWGNQAERLNAGTYFLFYTLAGSLPLLVALLYLYNTAGSLSIISMNLISIHPDTWANTFLWVACLIAFLVKMPLYGVHLWLPKAHVEAPIAGSMILAAVLLKLGGYGMIRMTIILEPTTKSLAYPFIILALWGIIMTGSICMRQSDMKSLIAYSSVSHMGLVASGILIQTPWGFTGAIILMIAHGLTSSALFCLANTTYERTHSRTLLLARGMQIIMPLMATWWLIMSLANMALPPLPNLMGELMIMISMFNWSAWTILLTGTGTLITAGYSLYLFVSSQRGPTSNNSSMEPSHTREHLLLTLHIIPVLLLMAKPELIWGWCW

Q8HMR5
type: Protein
reviewed: false
created: 2003-03-01
modified: 2022-12-14
version: 88
mnemonic: Q8HMR5_POLSE
citation: http://purl.uniprot.org/citations/12470943
recommended name: SIPC3FAAD39E4A0A720
enzyme: http://purl.uniprot.org/enzyme/7.1.1.2
organism: http://purl.uniprot.org/taxonomy/178879
encoded in: Mitochondrion
annotation: SIP22F76869FE613C22
annotation: SIP131F1FF4624D36A6
annotation: SIP807B5F345DCD5167
annotation: SIPB6AB1700ADB9B830
annotation: SIP0CDB6887F9819602
annotation: SIPF70EC52A251B7BC7
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/999
classified with: http://purl.uniprot.org/keywords/520
classified with: http://purl.uniprot.org/keywords/679
classified with: http://purl.uniprot.org/keywords/1278
classified with: http://purl.uniprot.org/keywords/1133
classified with: http://purl.uniprot.org/keywords/830
classified with: GO_0005743
classified with: GO_0070469
classified with: GO_0008137
classified with: GO_0042773
sequence: MTHILFTISTAFMLGLSGLTFNRTHLLSALLCLEGMMLSLFIALAMWCSQNETMMFSSTPLLLLALSACEAGLGLSLLVATSRTHGSDHLKNLNLLQC

Q8HMR5-citation-12470943
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

IPR001133
type: Resource
database: InterPro
comment: NADH_UbQ_OxRdtase_chain4L/K

IPR039428
type: Resource
database: InterPro
comment: NUOK/Mnh_C1-like

PTHR11434
type: Resource
database: PANTHER
comment: NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L
signature sequence match: PANTHER PTHR11434 match 1

PF00420
type: Resource
database: Pfam
comment: Oxidored_q2
signature sequence match: Pfam PF00420 match 1

SIPC3FAAD39E4A0A720
type: Structured Name
full name: NADH-ubiquinone oxidoreductase chain 4L
ec name: 7.1.1.2

ND4L
type: Gene

SIP22F76869FE613C22
type: Function Annotation
comment: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.

SIPB6AB1700ADB9B830
type: Similarity Annotation
comment: Belongs to the complex I subunit 4L family.

SIP0CDB6887F9819602
type: Transmembrane Annotation
comment: Helical
range: 22861356299597102tt28tt49

22861356299597102tt28
type: Position
type: ExactPosition
position: 28
reference: MTHILFTISTAFMLGLSGLTFNRTHLLSALLCLEGMMLSLFIALAMWCSQNETMMFSSTPLLLLALSACEAGLGLSLLVATSRTHGSDHLKNLNLLQC

22861356299597102tt49
type: Position
type: ExactPosition
position: 49
reference: MTHILFTISTAFMLGLSGLTFNRTHLLSALLCLEGMMLSLFIALAMWCSQNETMMFSSTPLLLLALSACEAGLGLSLLVATSRTHGSDHLKNLNLLQC

SIPF70EC52A251B7BC7
type: Transmembrane Annotation
comment: Helical
range: 22861356299597102tt61tt80

22861356299597102tt61
type: Position
type: ExactPosition
position: 61
reference: MTHILFTISTAFMLGLSGLTFNRTHLLSALLCLEGMMLSLFIALAMWCSQNETMMFSSTPLLLLALSACEAGLGLSLLVATSRTHGSDHLKNLNLLQC

22861356299597102tt80
type: Position
type: ExactPosition
position: 80
reference: MTHILFTISTAFMLGLSGLTFNRTHLLSALLCLEGMMLSLFIALAMWCSQNETMMFSSTPLLLLALSACEAGLGLSLLVATSRTHGSDHLKNLNLLQC

MTHILFTISTAFMLGLSGLTFNRTHLLSALLCLEGMMLSLFIALAMWCSQNETMMFSSTPLLLLALSACEAGLGLSLLVATSRTHGSDHLKNLNLLQC
type: Simple Sequence
modified: 2003-03-01
version: 1
mass: 10619

Q8HMR7
type: Protein
reviewed: false
created: 2003-03-01
modified: 2022-12-14
version: 86
mnemonic: Q8HMR7_POLSE
citation: http://purl.uniprot.org/citations/12470943
recommended name: SIP63E3671E8FBB9F10
organism: http://purl.uniprot.org/taxonomy/178879
encoded in: Mitochondrion
annotation: SIP01420179F0902A3E
annotation: SIPB01E47A26D12ACFD
annotation: SIP466AD101603BC98A
annotation: SIPC4C4148F890D064E
annotation: SIPB3C1F0313C4950D5
annotation: SIP9D891BDC48189F69
annotation: SIP5A0319F9FB2846DC
annotation: SIP514E146856D0C94B
annotation: SIPCF30E3AEF7F0B62D
annotation: SIPA29237F1402D8FE7
annotation: SIPFB078AB34F3FD001
annotation: SIP971E7CACA487F214
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/496
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0016020
classified with: GO_0005739
classified with: GO_0004129
classified with: GO_0019646
sequence: Q8HMR7-1

Q8HMR7-citation-12470943
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

cd01665
type: Resource
database: CDD
comment: Cyt_c_Oxidase_III
signature sequence match: CDD cd01665 match 1

IPR024791
type: Resource
database: InterPro
comment: Cyt_c/ubiquinol_Oxase_su3

IPR033945
type: Resource
database: InterPro
comment: Cyt_c_oxase_su3_dom

IPR000298
type: Resource
database: InterPro
comment: Cyt_c_oxidase-like_su3

IPR035973
type: Resource
database: InterPro
comment: Cyt_c_oxidase_su3-like_sf

IPR013833
type: Resource
database: InterPro
comment: Cyt_c_oxidase_su3_a-hlx

PTHR11403
type: Resource
database: PANTHER
comment: CYTOCHROME C OXIDASE SUBUNIT III
signature sequence match: PANTHER PTHR11403 match 1

PF00510
type: Resource
database: Pfam
comment: COX3
signature sequence match: Pfam PF00510 match 1

SSF81452
type: Resource
database: SUPFAM
comment: Cytochrome c oxidase subunit III-like
signature sequence match: SUPFAM SSF81452 match 1

PS50253
type: Resource
database: PROSITE
comment: COX3
signature sequence match: PROSITE PS50253 match 1

SIP63E3671E8FBB9F10
type: Structured Name
full name: Cytochrome c oxidase subunit 3

COIII
type: Gene

SIP01420179F0902A3E
type: Function Annotation
comment: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

SIP466AD101603BC98A
type: Subunit Annotation
comment: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).

SIPB3C1F0313C4950D5
type: Similarity Annotation
comment: Belongs to the cytochrome c oxidase subunit 3 family.

SIP9D891BDC48189F69
type: Transmembrane Annotation
comment: Helical
range: 22861356299597614tt16tt35

22861356299597614tt16
type: Position
type: ExactPosition
position: 16
reference: Q8HMR7-1

22861356299597614tt35
type: Position
type: ExactPosition
position: 35
reference: Q8HMR7-1

SIP5A0319F9FB2846DC
type: Transmembrane Annotation
comment: Helical
range: 22861356299597614tt41tt58

22861356299597614tt41
type: Position
type: ExactPosition
position: 41
reference: Q8HMR7-1

22861356299597614tt58
type: Position
type: ExactPosition
position: 58
reference: Q8HMR7-1

SIP514E146856D0C94B
type: Transmembrane Annotation
comment: Helical
range: 22861356299597614tt79tt102

22861356299597614tt79
type: Position
type: ExactPosition
position: 79
reference: Q8HMR7-1

22861356299597614tt102
type: Position
type: ExactPosition
position: 102
reference: Q8HMR7-1

SIPCF30E3AEF7F0B62D
type: Transmembrane Annotation
comment: Helical
range: 22861356299597614tt159tt177

22861356299597614tt159
type: Position
type: ExactPosition
position: 159
reference: Q8HMR7-1

22861356299597614tt177
type: Position
type: ExactPosition
position: 177
reference: Q8HMR7-1

SIPA29237F1402D8FE7
type: Transmembrane Annotation
comment: Helical
range: 22861356299597614tt197tt220

22861356299597614tt197
type: Position
type: ExactPosition
position: 197
reference: Q8HMR7-1

22861356299597614tt220
type: Position
type: ExactPosition
position: 220
reference: Q8HMR7-1

SIPFB078AB34F3FD001
type: Transmembrane Annotation
comment: Helical
range: 22861356299597614tt240tt260

22861356299597614tt240
type: Position
type: ExactPosition
position: 240
reference: Q8HMR7-1

22861356299597614tt260
type: Position
type: ExactPosition
position: 260
reference: Q8HMR7-1

SIP971E7CACA487F214
type: Domain Extent Annotation
comment: COX3
range: 22861356299597614tt4tt261

22861356299597614tt4
type: Position
type: ExactPosition
position: 4
reference: Q8HMR7-1

22861356299597614tt261
type: Position
type: ExactPosition
position: 261
reference: Q8HMR7-1

Q8HMR7-1
type: Simple Sequence
modified: 2003-03-01
version: 1
mass: 29556
value: MAHQAHAYHMVDPSPWPLTGAVAALLLTSGLAVWFHFKSMTLLAMGLLLMILTMIQWWRDIIREGTFQGHHTPPVQKGLRYGMILFITSEVFFFLGFFWAFYHSSLAPTPELGGIWPPTGITPLDPFEVPLLNTAVLLASGVTVTWAHHSLMEGKRTEATQALTLTILLGLYFTALQAMEYYEAPFTIADGVYGTTFFVATGFHGLHVIIGSTFLMVCLLRQILYHFTSSHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS

Q8HMR1
type: Protein
reviewed: false
created: 2003-03-01
modified: 2022-12-14
version: 94
mnemonic: Q8HMR1_POLSE
citation: http://purl.uniprot.org/citations/12470943
recommended name: SIP04BB22F94509478D
organism: http://purl.uniprot.org/taxonomy/178879
encoded in: Mitochondrion
annotation: SIPE1BACD510CAF0B6F
annotation: SIPDF8C3905A8DE241A
annotation: SIP8737D46676A23145
annotation: SIP235C55D2C53DFC22
annotation: SIPABFAAFF655DB7CD6
annotation: SIP2D9A8CDEF30C95F2
annotation: SIP7BE35643E56AAA18
annotation: SIPA80991CA1A9B1508
annotation: SIP289C6B8C11392A6B
annotation: SIPFD2F7243ADD34C9F
annotation: SIP84F1238B8418F644
annotation: SIPEE73604AA6549F44
annotation: SIP0D643B79F8608E0A
annotation: SIP6C355566F7098D49
annotation: SIP2EE1B64F75EAF856
annotation: SIP665B01D4B893376B
annotation: SIP2D54CA5956E5B2E6
annotation: SIP04CB510D29A049BF
annotation: SIPB50494A27B9AADDC
annotation: SIPD6D340D2992FC9EA
annotation: SIP4B11F9FAD8D8FFC0
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/349
classified with: http://purl.uniprot.org/keywords/999
classified with: http://purl.uniprot.org/keywords/679
classified with: http://purl.uniprot.org/keywords/1133
classified with: http://purl.uniprot.org/keywords/830
classified with: GO_0005743
classified with: GO_0045275
classified with: GO_0046872
classified with: GO_0008121
classified with: GO_0022904
sequence: Q8HMR1-1

Q8HMR1-citation-12470943
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

cd00290
type: Resource
database: CDD
comment: cytochrome_b_C
signature sequence match: CDD cd00290 match 1

cd00284
type: Resource
database: CDD
comment: Cytochrome_b_N
signature sequence match: CDD cd00284 match 1

IPR005798
type: Resource
database: InterPro
comment: Cyt_b/b6_C

IPR036150
type: Resource
database: InterPro
comment: Cyt_b/b6_C_sf

IPR005797
type: Resource
database: InterPro
comment: Cyt_b/b6_N

IPR027387
type: Resource
database: InterPro
comment: Cytb/b6-like_sf

IPR030689
type: Resource
database: InterPro
comment: Cytochrome_b

IPR016174
type: Resource
database: InterPro
comment: Di-haem_cyt_TM

PF00032
type: Resource
database: Pfam
comment: Cytochrom_B_C
signature sequence match: Pfam PF00032 match 1

PF00033
type: Resource
database: Pfam
comment: Cytochrome_B
signature sequence match: Pfam PF00033 match 1

PIRSF038885
type: Resource
database: PIRSF
comment: COB
signature sequence match: PIRSF PIRSF038885 match 1

SSF81648
type: Resource
database: SUPFAM
comment: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
signature sequence match: SUPFAM SSF81648 match 1

SSF81342
type: Resource
database: SUPFAM
comment: Transmembrane di-heme cytochromes
signature sequence match: SUPFAM SSF81342 match 1

PS51003
type: Resource
database: PROSITE
comment: CYTB_CTER
signature sequence match: PROSITE PS51003 match 1

PS51002
type: Resource
database: PROSITE
comment: CYTB_NTER
signature sequence match: PROSITE PS51002 match 1

SIP04BB22F94509478D
type: Structured Name
full name: Cytochrome b

cytb
type: Gene

SIPE1BACD510CAF0B6F
type: Function Annotation
comment: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.

SIPDF8C3905A8DE241A
type: Cofactor Annotation
comment: Binds 2 heme groups non-covalently.
cofactor: CHEBI_60344

SIP8737D46676A23145
type: Cofactor Annotation
comment: Binds 2 heme groups non-covalently.
cofactor: CHEBI_30413

SIPABFAAFF655DB7CD6
type: Similarity Annotation
comment: Belongs to the cytochrome b family.

SIP2D9A8CDEF30C95F2
type: Transmembrane Annotation
comment: Helical
range: 22861356299596078tt30tt56

22861356299596078tt30
type: Position
type: ExactPosition
position: 30
reference: Q8HMR1-1

22861356299596078tt56
type: Position
type: ExactPosition
position: 56
reference: Q8HMR1-1

SIP7BE35643E56AAA18
type: Transmembrane Annotation
comment: Helical
range: 22861356299596078tt77tt98

22861356299596078tt77
type: Position
type: ExactPosition
position: 77
reference: Q8HMR1-1

22861356299596078tt98
type: Position
type: ExactPosition
position: 98
reference: Q8HMR1-1

SIPA80991CA1A9B1508
type: Transmembrane Annotation
comment: Helical
range: 22861356299596078tt113tt133

22861356299596078tt113
type: Position
type: ExactPosition
position: 113
reference: Q8HMR1-1

22861356299596078tt133
type: Position
type: ExactPosition
position: 133
reference: Q8HMR1-1

SIP289C6B8C11392A6B
type: Transmembrane Annotation
comment: Helical
range: 22861356299596078tt140tt157

22861356299596078tt140
type: Position
type: ExactPosition
position: 140
reference: Q8HMR1-1

22861356299596078tt157
type: Position
type: ExactPosition
position: 157
reference: Q8HMR1-1

SIPFD2F7243ADD34C9F
type: Transmembrane Annotation
comment: Helical
range: 22861356299596078tt177tt200

22861356299596078tt177
type: Position
type: ExactPosition
position: 177
reference: Q8HMR1-1

22861356299596078tt200
type: Position
type: ExactPosition
position: 200
reference: Q8HMR1-1

SIP84F1238B8418F644
type: Transmembrane Annotation
comment: Helical
range: 22861356299596078tt229tt250

22861356299596078tt229
type: Position
type: ExactPosition
position: 229
reference: Q8HMR1-1

22861356299596078tt250
type: Position
type: ExactPosition
position: 250
reference: Q8HMR1-1

SIPEE73604AA6549F44
type: Transmembrane Annotation
comment: Helical
range: 22861356299596078tt288tt307

22861356299596078tt288
type: Position
type: ExactPosition
position: 288
reference: Q8HMR1-1

22861356299596078tt307
type: Position
type: ExactPosition
position: 307
reference: Q8HMR1-1

SIP0D643B79F8608E0A
type: Transmembrane Annotation
comment: Helical
range: 22861356299596078tt319tt338

22861356299596078tt319
type: Position
type: ExactPosition
position: 319
reference: Q8HMR1-1

22861356299596078tt338
type: Position
type: ExactPosition
position: 338
reference: Q8HMR1-1

SIP6C355566F7098D49
type: Transmembrane Annotation
comment: Helical
range: 22861356299596078tt350tt372

22861356299596078tt350
type: Position
type: ExactPosition
position: 350
reference: Q8HMR1-1

22861356299596078tt372
type: Position
type: ExactPosition
position: 372
reference: Q8HMR1-1

SIP2EE1B64F75EAF856
type: Domain Extent Annotation
comment: CYTB_NTER
range: 22861356299596078tt1tt209

22861356299596078tt1
type: Position
type: ExactPosition
position: 1
reference: Q8HMR1-1

22861356299596078tt209
type: Position
type: ExactPosition
position: 209
reference: Q8HMR1-1

SIP665B01D4B893376B
type: Domain Extent Annotation
comment: CYTB_CTER
range: 22861356299596078tt210tt380

22861356299596078tt210
type: Position
type: ExactPosition
position: 210
reference: Q8HMR1-1

22861356299596078tt380
type: Position
type: ExactPosition
position: 380
reference: Q8HMR1-1

SIP2D54CA5956E5B2E6
type: Binding Site Annotation
comment: axial binding residue
ligand: b562
ligand part: SIP3DC6E50EC00A509E
range: 22861356299596078tt83tt83

22861356299596078tt83
type: Position
type: ExactPosition
position: 83
reference: Q8HMR1-1

SIP04CB510D29A049BF
type: Binding Site Annotation
comment: axial binding residue
ligand: b566
ligand part: SIPDEA17CD1404F7F17
range: 22861356299596078tt97tt97

22861356299596078tt97
type: Position
type: ExactPosition
position: 97
reference: Q8HMR1-1

SIPB50494A27B9AADDC
type: Binding Site Annotation
comment: axial binding residue
ligand: b562
ligand part: SIP3DC6E50EC00A509E
range: 22861356299596078tt182tt182

22861356299596078tt182
type: Position
type: ExactPosition
position: 182
reference: Q8HMR1-1

SIPD6D340D2992FC9EA
type: Binding Site Annotation
comment: axial binding residue
ligand: b566
ligand part: SIPDEA17CD1404F7F17
range: 22861356299596078tt196tt196

22861356299596078tt196
type: Position
type: ExactPosition
position: 196
reference: Q8HMR1-1

22861356299596078tt201
type: Position
type: ExactPosition
position: 201
reference: Q8HMR1-1

b562
subclass of: CHEBI_60344

b566
subclass of: CHEBI_60344

Q8HMR1-1
type: Simple Sequence
modified: 2003-03-01
version: 1
mass: 42795
value: MAITRKTHPLAKIINSAFIDLPAPSNISSWWNMGSLLGMCLMSQIITGLFLAMHYVSDISSAFSSVAHICRDVNYGWLIRNFHANGASLFFICIYLHIARGLYYGSYLYMETWNIGVILLLLTMMTAFVGYVLPWGQMSFWGATVITNLLSAIPYIGDTLVQWIWGGFSVDKPTLTRFFAFHFILPFAIAAASLVHIVFLHETGSNNPMGINSNADKIPFHPYYTFKDLLGFIILLLIIISLALLSPNLLNDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLFSIIILMLVPFLHTSKIRSATFRPLFKITLWILAADVLILTWIGGQPVEDPYITIGQVASILYFLIFLVFMPMSGWIENKMLNRN

Q8HMS0
type: Protein
reviewed: false
created: 2003-03-01
modified: 2022-12-14
version: 111
mnemonic: Q8HMS0_POLSE
citation: http://purl.uniprot.org/citations/12470943
recommended name: SIP1B9C7925A4D98EBA
organism: http://purl.uniprot.org/taxonomy/178879
encoded in: Mitochondrion
annotation: SIP0DF78564F7187DB2
annotation: SIPED2D2EFE67FB4B1B
annotation: SIPF26BCD2012CC3608
annotation: SIPC3D0387B8876D88F
annotation: SIPA3BA5336FB7175FA
annotation: SIP978605FA447C74BB
annotation: SIPDD439AFA07D5B3CF
annotation: SIPE1E4A7ACD8E58DAB
annotation: SIP47107B7C295BAFD9
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/186
classified with: http://purl.uniprot.org/keywords/460
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/999
classified with: http://purl.uniprot.org/keywords/679
classified with: http://purl.uniprot.org/keywords/1278
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0005743
classified with: GO_0070469
classified with: GO_0005507
classified with: GO_0004129
sequence: Q8HMS0-1

Q8HMS0-citation-12470943
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

cd13912
type: Resource
database: CDD
comment: CcO_II_C
signature sequence match: CDD cd13912 match 1

IPR045187
type: Resource
database: InterPro
comment: CcO_II

IPR002429
type: Resource
database: InterPro
comment: CcO_II-like_C

IPR034210
type: Resource
database: InterPro
comment: CcO_II_C

IPR001505
type: Resource
database: InterPro
comment: Copper_CuA

IPR008972
type: Resource
database: InterPro
comment: Cupredoxin

IPR014222
type: Resource
database: InterPro
comment: Cyt_c_oxidase_su2

IPR011759
type: Resource
database: InterPro
comment: Cyt_c_oxidase_su2_TM_dom

IPR036257
type: Resource
database: InterPro
comment: Cyt_c_oxidase_su2_TM_sf

PTHR22888
type: Resource
database: PANTHER
comment: CYTOCHROME C OXIDASE, SUBUNIT II
signature sequence match: PANTHER PTHR22888 match 1

PF00116
type: Resource
database: Pfam
comment: COX2
signature sequence match: Pfam PF00116 match 1

PF02790
type: Resource
database: Pfam
comment: COX2_TM
signature sequence match: Pfam PF02790 match 1

SSF49503
type: Resource
database: SUPFAM
comment: Cupredoxins
signature sequence match: SUPFAM SSF49503 match 1

SSF81464
type: Resource
database: SUPFAM
comment: Cytochrome c oxidase subunit II-like, transmembrane region
signature sequence match: SUPFAM SSF81464 match 1

TIGR02866
type: Resource
database: TIGRFAMs
comment: CoxB
signature sequence match: TIGRFAMs TIGR02866 match 1

PS00078
type: Resource
database: PROSITE
comment: COX2
signature sequence match: PROSITE PS00078 match 1

PS50857
type: Resource
database: PROSITE
comment: COX2_CUA
signature sequence match: PROSITE PS50857 match 1

PS50999
type: Resource
database: PROSITE
comment: COX2_TM
signature sequence match: PROSITE PS50999 match 1

SIP1B9C7925A4D98EBA
type: Structured Name
full name: Cytochrome c oxidase subunit 2

COII
type: Gene

SIP0DF78564F7187DB2
type: Function Annotation
comment: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

SIPF26BCD2012CC3608
type: Cofactor Annotation
comment: Binds a copper A center.
cofactor: CHEBI_23378

SIPA3BA5336FB7175FA
type: Similarity Annotation
comment: Belongs to the cytochrome c oxidase subunit 2 family.

SIP978605FA447C74BB
type: Transmembrane Annotation
comment: Helical
range: 22861356299661358tt26tt43

22861356299661358tt26
type: Position
type: ExactPosition
position: 26
reference: Q8HMS0-1

22861356299661358tt43
type: Position
type: ExactPosition
position: 43
reference: Q8HMS0-1

SIPDD439AFA07D5B3CF
type: Transmembrane Annotation
comment: Helical
range: 22861356299661358tt63tt85

22861356299661358tt63
type: Position
type: ExactPosition
position: 63
reference: Q8HMS0-1

22861356299661358tt85
type: Position
type: ExactPosition
position: 85
reference: Q8HMS0-1

SIPE1E4A7ACD8E58DAB
type: Domain Extent Annotation
comment: COX2_TM
range: 22861356299661358tt1tt91

22861356299661358tt1
type: Position
type: ExactPosition
position: 1
reference: Q8HMS0-1

22861356299661358tt91
type: Position
type: ExactPosition
position: 91
reference: Q8HMS0-1

SIP47107B7C295BAFD9
type: Domain Extent Annotation
comment: COX2_CUA
range: 22861356299661358tt92tt225

22861356299661358tt92
type: Position
type: ExactPosition
position: 92
reference: Q8HMS0-1

22861356299661358tt225
type: Position
type: ExactPosition
position: 225
reference: Q8HMS0-1

Q8HMS0-1
type: Simple Sequence
modified: 2003-03-01
version: 1
mass: 25931
value: MAHPAQLGLQDASSPIMEELLHFHDHALMIVFLISTLVLYIITTTVSTKLTNKHLLDAQEIEMVWTVMPALVLITIALPSLRILYLMDEINDPHLTIKATGHQWYWSYEYTDYETLNFDSYMVPTQDLLPGQFRLLDTDNRMVVPTNSPVRMLITAEDVLHSWAVPSLGLKMDAVPGRLNQATFIATRPGIFFGQCSEICGANHSFMPIAIESAPVKYFESWSSSMLAES

Q8HMS2
type: Protein
reviewed: false
created: 2003-03-01
modified: 2022-12-14
version: 92
mnemonic: Q8HMS2_POLSE
citation: http://purl.uniprot.org/citations/12470943
recommended name: SIP43EA97D6E21C37A3
enzyme: http://purl.uniprot.org/enzyme/7.1.1.2
organism: http://purl.uniprot.org/taxonomy/178879
encoded in: Mitochondrion
annotation: SIP06DBC0B82DB4DD0D
annotation: SIPA973AB09750B9260
annotation: SIPAE798421D7735787
annotation: SIPC48C74CD76E839D5
annotation: SIP8181E092D07EAB8F
annotation: SIP188495E2036F72E8
annotation: SIPEDA4CB53FF80AADC
annotation: SIP400709E7D3999261
annotation: SIPD6443AA10E76DD9A
annotation: SIPD2A4391FC568A728
annotation: SIP97747F0491A64E12
annotation: SIP9940F457A7887B8C
annotation: SIP77708365A79D31E8
annotation: SIPCE0EB850F3CE6B35
annotation: SIP4FC722D97C07ABA5
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/999
classified with: http://purl.uniprot.org/keywords/520
classified with: http://purl.uniprot.org/keywords/679
classified with: http://purl.uniprot.org/keywords/1278
classified with: http://purl.uniprot.org/keywords/1133
classified with: http://purl.uniprot.org/keywords/830
classified with: GO_0005743
classified with: GO_0070469
classified with: GO_0008137
classified with: GO_0006120
sequence: Q8HMS2-1

Q8HMS2-citation-12470943
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

IPR010933
type: Resource
database: InterPro
comment: NADH_DH_su2_C

IPR003917
type: Resource
database: InterPro
comment: NADH_UbQ_OxRdtase_chain2

PF06444
type: Resource
database: Pfam
comment: NADH_dehy_S2_C
signature sequence match: Pfam PF06444 match 1

PR01436
type: Resource
database: PRINTS
comment: NADHDHGNASE2

SIP43EA97D6E21C37A3
type: Structured Name
full name: NADH-ubiquinone oxidoreductase chain 2
ec name: 7.1.1.2

ND2
type: Gene

SIP06DBC0B82DB4DD0D
type: Function Annotation
comment: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

SIPC48C74CD76E839D5
type: Similarity Annotation
comment: Belongs to the complex I subunit 2 family.

SIP8181E092D07EAB8F
type: Transmembrane Annotation
comment: Helical
range: 22861356299661870tt26tt45

22861356299661870tt26
type: Position
type: ExactPosition
position: 26
reference: Q8HMS2-1

22861356299661870tt45
type: Position
type: ExactPosition
position: 45
reference: Q8HMS2-1

SIP188495E2036F72E8
type: Transmembrane Annotation
comment: Helical
range: 22861356299661870tt57tt75

22861356299661870tt57
type: Position
type: ExactPosition
position: 57
reference: Q8HMS2-1

22861356299661870tt75
type: Position
type: ExactPosition
position: 75
reference: Q8HMS2-1

SIPEDA4CB53FF80AADC
type: Transmembrane Annotation
comment: Helical
range: 22861356299661870tt95tt114

22861356299661870tt95
type: Position
type: ExactPosition
position: 95
reference: Q8HMS2-1

22861356299661870tt114
type: Position
type: ExactPosition
position: 114
reference: Q8HMS2-1

SIP400709E7D3999261
type: Transmembrane Annotation
comment: Helical
range: 22861356299661870tt152tt170

22861356299661870tt152
type: Position
type: ExactPosition
position: 152
reference: Q8HMS2-1

22861356299661870tt170
type: Position
type: ExactPosition
position: 170
reference: Q8HMS2-1

SIPD6443AA10E76DD9A
type: Transmembrane Annotation
comment: Helical
range: 22861356299661870tt177tt195

22861356299661870tt177
type: Position
type: ExactPosition
position: 177
reference: Q8HMS2-1

22861356299661870tt195
type: Position
type: ExactPosition
position: 195
reference: Q8HMS2-1

SIPD2A4391FC568A728
type: Transmembrane Annotation
comment: Helical
range: 22861356299661870tt201tt221

22861356299661870tt201
type: Position
type: ExactPosition
position: 201
reference: Q8HMS2-1

22861356299661870tt221
type: Position
type: ExactPosition
position: 221
reference: Q8HMS2-1

SIP97747F0491A64E12
type: Transmembrane Annotation
comment: Helical
range: 22861356299661870tt233tt253

22861356299661870tt233
type: Position
type: ExactPosition
position: 233
reference: Q8HMS2-1

22861356299661870tt253
type: Position
type: ExactPosition
position: 253
reference: Q8HMS2-1

SIP9940F457A7887B8C
type: Transmembrane Annotation
comment: Helical
range: 22861356299661870tt273tt293

22861356299661870tt273
type: Position
type: ExactPosition
position: 273
reference: Q8HMS2-1

22861356299661870tt293
type: Position
type: ExactPosition
position: 293
reference: Q8HMS2-1

SIP77708365A79D31E8
type: Transmembrane Annotation
comment: Helical
range: 22861356299661870tt322tt342

22861356299661870tt322
type: Position
type: ExactPosition
position: 322
reference: Q8HMS2-1

22861356299661870tt342
type: Position
type: ExactPosition
position: 342
reference: Q8HMS2-1

SIPCE0EB850F3CE6B35
type: Domain Extent Annotation
comment: Proton_antipo_M
range: 22861356299661870tt23tt285

22861356299661870tt23
type: Position
type: ExactPosition
position: 23
reference: Q8HMS2-1

22861356299661870tt285
type: Position
type: ExactPosition
position: 285
reference: Q8HMS2-1

SIP4FC722D97C07ABA5
type: Domain Extent Annotation
comment: NADH_dehy_S2_C
range: 22861356299661870tt289tt342

22861356299661870tt289
type: Position
type: ExactPosition
position: 289
reference: Q8HMS2-1

Q8HMS2-1
type: Simple Sequence
modified: 2003-03-01
version: 1
mass: 38042
value: MSPYILFIMLMSLGLGTTLTFASSNWFLAWMGLEINTLAIIPLMARHHHPRAVEAATKYFITQAAAAALLLFAGLMNAWQSGQWIIQDMSMPTSALMTLAIAIKLGVAPMHFWLPEVMQGITLNTGLILATWQKLAPLALLYQISNNLMPELMIILGLTSTFIGGWGGLNQTQIRKIMAYSSIAHLGWIISIMHFMPTLAIINLIIYIIMTTTMFMTFNVTNSTSISTLAMNWSKFPTLSAITMLALLSLGGLPPLSGFLPKWLILQELTNQGLMPTATMIALSALLSLYFYLRLSYSLTTTVTPNTHAQTLNWGTKTKTSFILPVVMVMTITMLPISPSIISLF

Q8HMS1
type: Protein
reviewed: false
created: 2003-03-01
modified: 2022-12-14
version: 101
mnemonic: Q8HMS1_POLSE
citation: http://purl.uniprot.org/citations/12470943
recommended name: SIP99F797808497C9B3
enzyme: http://purl.uniprot.org/enzyme/7.1.1.9
organism: http://purl.uniprot.org/taxonomy/178879
encoded in: Mitochondrion
annotation: SIPDA708883FAB22D85
annotation: SIPAA21BB3552717FA4
annotation: SIPD5B4DFD26F1C1CC4
annotation: SIP9BC003DA096B2AAE
annotation: SIP0BB4A1B631D24CA0
annotation: SIP0F65201D1F7B28EC
annotation: SIP254A764A425DA068
annotation: SIP7CF57083611F83DC
annotation: SIPD0B26FBA8498E044
annotation: SIP486C62F1E427E892
annotation: SIP7D52CBFDEDC72F3A
annotation: SIP8BA1C4F2931169A1
annotation: SIP40F9AF8A6706B7BA
annotation: SIP0F204B8BBEE84D70
annotation: SIPBB358D5AC42BFCBD
annotation: SIP4E5504499CC912B3
annotation: SIP76F7F592C6F49993
annotation: SIPD6945E751AC7617F
annotation: SIPF7D81B561D4703B8
annotation: SIPAD0BC7B857EB9D72
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/106
classified with: http://purl.uniprot.org/keywords/186
classified with: http://purl.uniprot.org/keywords/349
classified with: http://purl.uniprot.org/keywords/999
classified with: http://purl.uniprot.org/keywords/679
classified with: http://purl.uniprot.org/keywords/915
classified with: http://purl.uniprot.org/keywords/1278
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0005743
classified with: GO_0045277
classified with: GO_0004129
classified with: GO_0020037
classified with: GO_0046872
classified with: GO_0006119
sequence: Q8HMS1-1

Q8HMS1-citation-12470943
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

cd01663
type: Resource
database: CDD
comment: Cyt_c_Oxidase_I
signature sequence match: CDD cd01663 match 1

IPR023616
type: Resource
database: InterPro
comment: Cyt_c_oxase-like_su1_dom

IPR036927
type: Resource
database: InterPro
comment: Cyt_c_oxase-like_su1_sf

IPR000883
type: Resource
database: InterPro
comment: Cyt_C_Oxase_1

IPR023615
type: Resource
database: InterPro
comment: Cyt_c_Oxase_su1_BS

IPR033944
type: Resource
database: InterPro
comment: Cyt_c_oxase_su1_dom

PTHR10422
type: Resource
database: PANTHER
comment: CYTOCHROME C OXIDASE SUBUNIT 1
signature sequence match: PANTHER PTHR10422 match 1

PF00115
type: Resource
database: Pfam
comment: COX1
signature sequence match: Pfam PF00115 match 1

PR01165
type: Resource
database: PRINTS
comment: CYCOXIDASEI

SSF81442
type: Resource
database: SUPFAM
comment: Cytochrome c oxidase subunit I-like
signature sequence match: SUPFAM SSF81442 match 1

PS50855
type: Resource
database: PROSITE
comment: COX1
signature sequence match: PROSITE PS50855 match 1

PS00077
type: Resource
database: PROSITE
comment: COX1_CUB
signature sequence match: PROSITE PS00077 match 1

SIP99F797808497C9B3
type: Structured Name
full name: Cytochrome c oxidase subunit 1
ec name: 7.1.1.9

COI
type: Gene

SIPDA708883FAB22D85
type: Function Annotation
comment: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

SIP254A764A425DA068
type: Similarity Annotation
comment: Belongs to the heme-copper respiratory oxidase family.

SIP7CF57083611F83DC
type: Transmembrane Annotation
comment: Helical
range: 22861356299661614tt15tt37

22861356299661614tt15
type: Position
type: ExactPosition
position: 15
reference: Q8HMS1-1

22861356299661614tt37
type: Position
type: ExactPosition
position: 37
reference: Q8HMS1-1

SIPD0B26FBA8498E044
type: Transmembrane Annotation
comment: Helical
range: 22861356299661614tt57tt83

22861356299661614tt57
type: Position
type: ExactPosition
position: 57
reference: Q8HMS1-1

22861356299661614tt83
type: Position
type: ExactPosition
position: 83
reference: Q8HMS1-1

SIP486C62F1E427E892
type: Transmembrane Annotation
comment: Helical
range: 22861356299661614tt104tt126

22861356299661614tt104
type: Position
type: ExactPosition
position: 104
reference: Q8HMS1-1

22861356299661614tt126
type: Position
type: ExactPosition
position: 126
reference: Q8HMS1-1

SIP7D52CBFDEDC72F3A
type: Transmembrane Annotation
comment: Helical
range: 22861356299661614tt146tt171

22861356299661614tt146
type: Position
type: ExactPosition
position: 146
reference: Q8HMS1-1

22861356299661614tt171
type: Position
type: ExactPosition
position: 171
reference: Q8HMS1-1

SIP8BA1C4F2931169A1
type: Transmembrane Annotation
comment: Helical
range: 22861356299661614tt183tt210

22861356299661614tt183
type: Position
type: ExactPosition
position: 183
reference: Q8HMS1-1

22861356299661614tt210
type: Position
type: ExactPosition
position: 210
reference: Q8HMS1-1

SIP40F9AF8A6706B7BA
type: Transmembrane Annotation
comment: Helical
range: 22861356299661614tt243tt261

22861356299661614tt243
type: Position
type: ExactPosition
position: 243
reference: Q8HMS1-1

22861356299661614tt261
type: Position
type: ExactPosition
position: 261
reference: Q8HMS1-1

SIP0F204B8BBEE84D70
type: Transmembrane Annotation
comment: Helical
range: 22861356299661614tt268tt291

22861356299661614tt268
type: Position
type: ExactPosition
position: 268
reference: Q8HMS1-1

22861356299661614tt291
type: Position
type: ExactPosition
position: 291
reference: Q8HMS1-1

SIPBB358D5AC42BFCBD
type: Transmembrane Annotation
comment: Helical
range: 22861356299661614tt303tt327

22861356299661614tt303
type: Position
type: ExactPosition
position: 303
reference: Q8HMS1-1

22861356299661614tt327
type: Position
type: ExactPosition
position: 327
reference: Q8HMS1-1

SIP4E5504499CC912B3
type: Transmembrane Annotation
comment: Helical
range: 22861356299661614tt339tt359

22861356299661614tt339
type: Position
type: ExactPosition
position: 339
reference: Q8HMS1-1

22861356299661614tt359
type: Position
type: ExactPosition
position: 359
reference: Q8HMS1-1

SIP76F7F592C6F49993
type: Transmembrane Annotation
comment: Helical
range: 22861356299661614tt379tt400

22861356299661614tt379
type: Position
type: ExactPosition
position: 379
reference: Q8HMS1-1

22861356299661614tt400
type: Position
type: ExactPosition
position: 400
reference: Q8HMS1-1

SIPD6945E751AC7617F
type: Transmembrane Annotation
comment: Helical
range: 22861356299661614tt412tt430

22861356299661614tt412
type: Position
type: ExactPosition
position: 412
reference: Q8HMS1-1

22861356299661614tt430
type: Position
type: ExactPosition
position: 430
reference: Q8HMS1-1

SIPF7D81B561D4703B8
type: Transmembrane Annotation
comment: Helical
range: 22861356299661614tt450tt473

22861356299661614tt450
type: Position
type: ExactPosition
position: 450
reference: Q8HMS1-1

22861356299661614tt473
type: Position
type: ExactPosition
position: 473
reference: Q8HMS1-1

SIPAD0BC7B857EB9D72
type: Domain Extent Annotation
comment: COX1
range: 22861356299661614tt1tt517

22861356299661614tt1
type: Position
type: ExactPosition
position: 1
reference: Q8HMS1-1

22861356299661614tt517
type: Position
type: ExactPosition
position: 517
reference: Q8HMS1-1

Q8HMS1-1
type: Simple Sequence
modified: 2003-03-01
version: 1
mass: 57276
value: MTITRWLFSTNHKDIGTLYLIFGAWAGMVGTALSLLIRAELGQPGALMGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLTSSAVEAGVGTGWTVYPPLAGNLAHAGASVDLAIFSLHLAGVSSILGAINFITTIINMKPPSTSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVAYYSGKNEPFGYMGMVWAMMAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGAIKWETPMLWALGFIFLFTVGGLTGIILANSSLDIMLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFSGYTLHSTWTKIHFGVMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYTLWNSLSSIGSMISLTAVIMFLFILWEAFAAKREVQTVELTYTNVEWLHGCPPPYHTYEEPAFVQSPQARE

Q8HMS3
type: Protein
reviewed: false
created: 2003-03-01
modified: 2022-12-14
version: 78
mnemonic: Q8HMS3_POLSE
citation: http://purl.uniprot.org/citations/12470943
recommended name: SIPD7C66A1752115876
enzyme: http://purl.uniprot.org/enzyme/7.1.1.2
organism: http://purl.uniprot.org/taxonomy/178879
encoded in: Mitochondrion
annotation: SIP557EB173D315B857
annotation: SIPE10D5384BF71DB84
annotation: SIP720547C5D100E731
annotation: SIP1B57F7ED891ED60F
annotation: SIP3B861630D1474F5C
annotation: SIP8C95AFD9C222335A
annotation: SIP3665800BA6B4FC62
annotation: SIP2D779691C2EE4918
annotation: SIP61F4B60F3E8CFF1B
annotation: SIP661141C199066C59
annotation: SIP8D7299120F867FD1
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/496
classified with: http://purl.uniprot.org/keywords/520
classified with: http://purl.uniprot.org/keywords/1133
classified with: http://purl.uniprot.org/keywords/830
classified with: GO_0005743
classified with: GO_0008137
sequence: Q8HMS3-1

Q8HMS3-citation-12470943
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

MF_01350
type: Resource
database: HAMAP
comment: NDH1_NuoH
signature sequence match: HAMAP MF 01350 match 1

IPR001694
type: Resource
database: InterPro
comment: NADH_UbQ_OxRdtase_su1/FPO

IPR018086
type: Resource
database: InterPro
comment: NADH_UbQ_OxRdtase_su1_CS

PTHR11432
type: Resource
database: PANTHER
comment: NADH DEHYDROGENASE SUBUNIT 1
signature sequence match: PANTHER PTHR11432 match 1

PF00146
type: Resource
database: Pfam
comment: NADHdh
signature sequence match: Pfam PF00146 match 1

PS00667
type: Resource
database: PROSITE
comment: COMPLEX1_ND1_1
signature sequence match: PROSITE PS00667 match 1

PS00668
type: Resource
database: PROSITE
comment: COMPLEX1_ND1_2
signature sequence match: PROSITE PS00668 match 1

SIPD7C66A1752115876
type: Structured Name
full name: NADH-ubiquinone oxidoreductase chain 1
ec name: 7.1.1.2

ND1
type: Gene

SIP720547C5D100E731
type: Similarity Annotation
comment: Belongs to the complex I subunit 1 family.

SIP1B57F7ED891ED60F
type: Transmembrane Annotation
comment: Helical
range: 22861356299662126tt6tt27

22861356299662126tt6
type: Position
type: ExactPosition
position: 6
reference: Q8HMS3-1

22861356299662126tt27
type: Position
type: ExactPosition
position: 27
reference: Q8HMS3-1

SIP3B861630D1474F5C
type: Transmembrane Annotation
comment: Helical
range: 22861356299662126tt74tt93

22861356299662126tt74
type: Position
type: ExactPosition
position: 74
reference: Q8HMS3-1

22861356299662126tt93
type: Position
type: ExactPosition
position: 93
reference: Q8HMS3-1

SIP8C95AFD9C222335A
type: Transmembrane Annotation
comment: Helical
range: 22861356299662126tt105tt127

22861356299662126tt105
type: Position
type: ExactPosition
position: 105
reference: Q8HMS3-1

22861356299662126tt127
type: Position
type: ExactPosition
position: 127
reference: Q8HMS3-1

SIP3665800BA6B4FC62
type: Transmembrane Annotation
comment: Helical
range: 22861356299662126tt148tt169

22861356299662126tt148
type: Position
type: ExactPosition
position: 148
reference: Q8HMS3-1

22861356299662126tt169
type: Position
type: ExactPosition
position: 169
reference: Q8HMS3-1

SIP2D779691C2EE4918
type: Transmembrane Annotation
comment: Helical
range: 22861356299662126tt175tt195

22861356299662126tt175
type: Position
type: ExactPosition
position: 175
reference: Q8HMS3-1

22861356299662126tt195
type: Position
type: ExactPosition
position: 195
reference: Q8HMS3-1

SIP61F4B60F3E8CFF1B
type: Transmembrane Annotation
comment: Helical
range: 22861356299662126tt224tt247

22861356299662126tt224
type: Position
type: ExactPosition
position: 224
reference: Q8HMS3-1

22861356299662126tt247
type: Position
type: ExactPosition
position: 247
reference: Q8HMS3-1

SIP661141C199066C59
type: Transmembrane Annotation
comment: Helical
range: 22861356299662126tt253tt274

22861356299662126tt253
type: Position
type: ExactPosition
position: 253
reference: Q8HMS3-1

22861356299662126tt274
type: Position
type: ExactPosition
position: 274
reference: Q8HMS3-1

SIP8D7299120F867FD1
type: Transmembrane Annotation
comment: Helical
range: 22861356299662126tt294tt314

22861356299662126tt294
type: Position
type: ExactPosition
position: 294
reference: Q8HMS3-1

22861356299662126tt314
type: Position
type: ExactPosition
position: 314
reference: Q8HMS3-1

Q8HMS3-1
type: Simple Sequence
modified: 2003-03-01
version: 1
mass: 35232
value: MTLITLIINPLMYIVPVLLAMAFLTLVERKILGYMQLRKGPNIVGPYGLLQPIADGVKLFIKEPVKPSTASPTLFLLTPTLALTLALILWIPLPMPLALTDLNLTILFILAVSSLSVYSILGSGWASNSKYALIGALRAVAQTISYEVTLGLIILSLIMFTGAFTLITFNTTQEAVWLIMPAWPLAAMWFISTLAETNRAPFDLTEGESELVSGFNVEYAGGPFALFFLAEYTNILLMNALSAILFLGPSFNILTINLNWAIKTTLLASLFLWVRASYPRFRYDQLMHLVWKNFLPLTLALIIWHISLPISLAGSPPQL

Q8HMR3
type: Protein
reviewed: false
created: 2003-03-01
modified: 2022-12-14
version: 96
mnemonic: Q8HMR3_POLSE
citation: http://purl.uniprot.org/citations/12470943
recommended name: SIP9D7E862BB8D3C835
enzyme: http://purl.uniprot.org/enzyme/7.1.1.2
organism: http://purl.uniprot.org/taxonomy/178879
encoded in: Mitochondrion
annotation: SIPFBECDE3BE78088CB
annotation: SIP55984BB5BE29CA5C
annotation: SIPE1E83E2F0AC93B1A
annotation: SIPB8731CCE5E8E2FBA
annotation: SIP5AD1486DAC46AA61
annotation: SIP81980FF2A20AB43E
annotation: SIP7C2776DCDD3F7FC2
annotation: SIP577B2B46D370E979
annotation: SIP96778438AE764400
annotation: SIP4DE1E4348467EC25
annotation: SIP82B28B3434CC9EAC
annotation: SIP5C561CE49905FF9B
annotation: SIP977226B74A413F56
annotation: SIP40829F07B0C528FD
annotation: SIPDFAF686E0B93EF84
annotation: SIP78B7329748A15AD0
annotation: SIP5A440FE60B0EA5DF
annotation: SIP67C3B14CC6A54393
annotation: SIP852C9D68605ECA53
annotation: SIPF0373D90FC99C52F
annotation: SIP496DEA3E1BE1FF61
annotation: SIP1C0ACA621D5FD0D0
annotation: SIPCB936454DE7EE431
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/999
classified with: http://purl.uniprot.org/keywords/520
classified with: http://purl.uniprot.org/keywords/679
classified with: http://purl.uniprot.org/keywords/1133
classified with: http://purl.uniprot.org/keywords/830
classified with: GO_0005743
classified with: GO_0008137
classified with: GO_0042773
sequence: Q8HMR3-1

Q8HMR3-citation-12470943
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

IPR010934
type: Resource
database: InterPro
comment: NADH_DH_su5_C

IPR018393
type: Resource
database: InterPro
comment: NADHpl_OxRdtase_5_subgr

IPR003945
type: Resource
database: InterPro
comment: NU5C-like

IPR001516
type: Resource
database: InterPro
comment: Proton_antipo_N

PTHR42829
type: Resource
database: PANTHER
comment: NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5
signature sequence match: PANTHER PTHR42829 match 1

PF06455
type: Resource
database: Pfam
comment: NADH5_C
signature sequence match: Pfam PF06455 match 1

PF00662
type: Resource
database: Pfam
comment: Proton_antipo_N
signature sequence match: Pfam PF00662 match 1

TIGR01974
type: Resource
database: TIGRFAMs
comment: NDH_I_L
signature sequence match: TIGRFAMs TIGR01974 match 1

SIP9D7E862BB8D3C835
type: Structured Name
full name: NADH-ubiquinone oxidoreductase chain 5
ec name: 7.1.1.2

ND5
type: Gene

SIPFBECDE3BE78088CB
type: Function Annotation
comment: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

SIPB8731CCE5E8E2FBA
type: Similarity Annotation
comment: Belongs to the complex I subunit 5 family.

SIP5AD1486DAC46AA61
type: Transmembrane Annotation
comment: Helical
range: 22861356299596590tt6tt27

22861356299596590tt6
type: Position
type: ExactPosition
position: 6
reference: Q8HMR3-1

22861356299596590tt27
type: Position
type: ExactPosition
position: 27
reference: Q8HMR3-1

SIP81980FF2A20AB43E
type: Transmembrane Annotation
comment: Helical
range: 22861356299596590tt47tt70

22861356299596590tt47
type: Position
type: ExactPosition
position: 47
reference: Q8HMR3-1

22861356299596590tt70
type: Position
type: ExactPosition
position: 70
reference: Q8HMR3-1

SIP7C2776DCDD3F7FC2
type: Transmembrane Annotation
comment: Helical
range: 22861356299596590tt90tt110

22861356299596590tt90
type: Position
type: ExactPosition
position: 90
reference: Q8HMR3-1

22861356299596590tt110
type: Position
type: ExactPosition
position: 110
reference: Q8HMR3-1

SIP577B2B46D370E979
type: Transmembrane Annotation
comment: Helical
range: 22861356299596590tt122tt139

22861356299596590tt122
type: Position
type: ExactPosition
position: 122
reference: Q8HMR3-1

22861356299596590tt139
type: Position
type: ExactPosition
position: 139
reference: Q8HMR3-1

SIP96778438AE764400
type: Transmembrane Annotation
comment: Helical
range: 22861356299596590tt145tt165

22861356299596590tt145
type: Position
type: ExactPosition
position: 145
reference: Q8HMR3-1

22861356299596590tt165
type: Position
type: ExactPosition
position: 165
reference: Q8HMR3-1

SIP4DE1E4348467EC25
type: Transmembrane Annotation
comment: Helical
range: 22861356299596590tt177tt196

22861356299596590tt177
type: Position
type: ExactPosition
position: 177
reference: Q8HMR3-1

22861356299596590tt196
type: Position
type: ExactPosition
position: 196
reference: Q8HMR3-1

SIP82B28B3434CC9EAC
type: Transmembrane Annotation
comment: Helical
range: 22861356299596590tt216tt239

22861356299596590tt216
type: Position
type: ExactPosition
position: 216
reference: Q8HMR3-1

22861356299596590tt239
type: Position
type: ExactPosition
position: 239
reference: Q8HMR3-1

SIP5C561CE49905FF9B
type: Transmembrane Annotation
comment: Helical
range: 22861356299596590tt251tt273

22861356299596590tt251
type: Position
type: ExactPosition
position: 251
reference: Q8HMR3-1

22861356299596590tt273
type: Position
type: ExactPosition
position: 273
reference: Q8HMR3-1

SIP977226B74A413F56
type: Transmembrane Annotation
comment: Helical
range: 22861356299596590tt279tt300

22861356299596590tt279
type: Position
type: ExactPosition
position: 279
reference: Q8HMR3-1

22861356299596590tt300
type: Position
type: ExactPosition
position: 300
reference: Q8HMR3-1

SIP40829F07B0C528FD
type: Transmembrane Annotation
comment: Helical
range: 22861356299596590tt307tt325

22861356299596590tt307
type: Position
type: ExactPosition
position: 307
reference: Q8HMR3-1

22861356299596590tt325
type: Position
type: ExactPosition
position: 325
reference: Q8HMR3-1

SIPDFAF686E0B93EF84
type: Transmembrane Annotation
comment: Helical
range: 22861356299596590tt331tt353

22861356299596590tt331
type: Position
type: ExactPosition
position: 331
reference: Q8HMR3-1

22861356299596590tt353
type: Position
type: ExactPosition
position: 353
reference: Q8HMR3-1

SIP78B7329748A15AD0
type: Transmembrane Annotation
comment: Helical
range: 22861356299596590tt374tt393

22861356299596590tt374
type: Position
type: ExactPosition
position: 374
reference: Q8HMR3-1

22861356299596590tt393
type: Position
type: ExactPosition
position: 393
reference: Q8HMR3-1

SIP5A440FE60B0EA5DF
type: Transmembrane Annotation
comment: Helical
range: 22861356299596590tt413tt437

22861356299596590tt413
type: Position
type: ExactPosition
position: 413
reference: Q8HMR3-1

22861356299596590tt437
type: Position
type: ExactPosition
position: 437
reference: Q8HMR3-1

SIP67C3B14CC6A54393
type: Transmembrane Annotation
comment: Helical
range: 22861356299596590tt463tt479

22861356299596590tt463
type: Position
type: ExactPosition
position: 463
reference: Q8HMR3-1

22861356299596590tt479
type: Position
type: ExactPosition
position: 479
reference: Q8HMR3-1

SIP852C9D68605ECA53
type: Transmembrane Annotation
comment: Helical
range: 22861356299596590tt491tt511

22861356299596590tt491
type: Position
type: ExactPosition
position: 491
reference: Q8HMR3-1

22861356299596590tt511
type: Position
type: ExactPosition
position: 511
reference: Q8HMR3-1

SIPF0373D90FC99C52F
type: Transmembrane Annotation
comment: Helical
range: 22861356299596590tt592tt612

22861356299596590tt592
type: Position
type: ExactPosition
position: 592
reference: Q8HMR3-1

22861356299596590tt612
type: Position
type: ExactPosition
position: 612
reference: Q8HMR3-1

SIP496DEA3E1BE1FF61
type: Domain Extent Annotation
comment: Proton_antipo_N
range: 22861356299596590tt73tt123

22861356299596590tt73
type: Position
type: ExactPosition
position: 73
reference: Q8HMR3-1

22861356299596590tt123
type: Position
type: ExactPosition
position: 123
reference: Q8HMR3-1

SIP1C0ACA621D5FD0D0
type: Domain Extent Annotation
comment: Proton_antipo_M
range: 22861356299596590tt139tt424

22861356299596590tt424
type: Position
type: ExactPosition
position: 424
reference: Q8HMR3-1

SIPCB936454DE7EE431
type: Domain Extent Annotation
comment: NADH5_C
range: 22861356299596590tt428tt610

22861356299596590tt428
type: Position
type: ExactPosition
position: 428
reference: Q8HMR3-1

22861356299596590tt610
type: Position
type: ExactPosition
position: 610
reference: Q8HMR3-1

Q8HMR3-1
type: Simple Sequence
modified: 2003-03-01
version: 1
mass: 68201
value: MSIPQLSQMFLTCLSLTIIILALPIILSIMFKPLNNWPHYVKNAVKLSFLVSLIPSLMCLNLNLQSFTIYYRWLLIPPTEINISFQFDQYSMIFMTIALYVTWSILEFAIYYMQTDILINRFFKYLLTFLIAMLILVTANNMFQLFIGWEGVGIMSFLLIGWWHGRADANMAALQAVIYNRVGDIGLMLSMSWLLINTNSWDIQQLFILTKNMDMTLPAAGLLLAATGKSAQFGLHPWLPAAMEGPTPVSALLHSSTMVVAGIFLLIRLHPLIENNNNILTAALCLGAITTLFTATCALTQNDIKKIVAFSTSSQLGLMMVAIGLNQPQLAFLHICTHAFFKAMLFLCSGSIIHSLNDEQDIRKMGGIHKTLPLTSSCLTIGSLALMGTPFLAGFFSKDAIIEALNTSNLNAWALMLTLIATSFTAVYSLRIIYFVLMNNPRTLPLSPINENNPLIANPIKRLAWGSIVAGLILCQYILPNKTQMLTMPPTLKLTGLIVSLLGLITALELASMTNKQIKISATKLTHNFSNMLGFYPHITHRLMSKLPLTLGQVFATQTSDQLWMEKLGPKGIAHAQLLTTQKITHAHKGLIKTYLSITVLSLFVIMLLIMFI

Q8HMR6
type: Protein
reviewed: false
created: 2003-03-01
modified: 2022-12-14
version: 72
mnemonic: Q8HMR6_POLSE
citation: http://purl.uniprot.org/citations/12470943
recommended name: SIP0691DD681D8B27AA
enzyme: http://purl.uniprot.org/enzyme/7.1.1.2
organism: http://purl.uniprot.org/taxonomy/178879
encoded in: Mitochondrion
annotation: SIP124A846BA907C622
annotation: SIP799A034292AEF087
annotation: SIPAD7B23EAAAC9B29F
annotation: SIPA8CAED86FCD62374
annotation: SIP073562169B0F8801
annotation: SIPDEB70E2E5001E0F8
annotation: SIP85786F60159E2229
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/496
classified with: http://purl.uniprot.org/keywords/520
classified with: http://purl.uniprot.org/keywords/679
classified with: http://purl.uniprot.org/keywords/1278
classified with: http://purl.uniprot.org/keywords/1133
classified with: http://purl.uniprot.org/keywords/830
classified with: GO_0031966
classified with: GO_0070469
classified with: GO_0008137
sequence: MNLILTMILISSSISTILAIVAFWLPQMNPDSEKLSPYECGFDPLGSARLPFSIRFFLVAILFLLFDLEIALLLPLPWGIHLDPMLMLTWAFVIIMLLTVGLIYEWLQGGLEWAE

Q8HMR6-citation-12470943
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

IPR000440
type: Resource
database: InterPro
comment: NADH_UbQ/plastoQ_OxRdtase_su3

IPR038430
type: Resource
database: InterPro
comment: NDAH_ubi_oxred_su3_sf

PTHR11058
type: Resource
database: PANTHER
comment: NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 3
signature sequence match: PANTHER PTHR11058 match 1

PF00507
type: Resource
database: Pfam
comment: Oxidored_q4
signature sequence match: Pfam PF00507 match 1

SIP0691DD681D8B27AA
type: Structured Name
full name: NADH-ubiquinone oxidoreductase chain 3
ec name: 7.1.1.2

ND3
type: Gene

SIP124A846BA907C622
type: Function Annotation
comment: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.

SIPA8CAED86FCD62374
type: Similarity Annotation
comment: Belongs to the complex I subunit 3 family.

SIP073562169B0F8801
type: Transmembrane Annotation
comment: Helical
range: 22861356299597358tt7tt25

22861356299597358tt7
type: Position
type: ExactPosition
position: 7
reference: MNLILTMILISSSISTILAIVAFWLPQMNPDSEKLSPYECGFDPLGSARLPFSIRFFLVAILFLLFDLEIALLLPLPWGIHLDPMLMLTWAFVIIMLLTVGLIYEWLQGGLEWAE

22861356299597358tt25
type: Position
type: ExactPosition
position: 25
reference: MNLILTMILISSSISTILAIVAFWLPQMNPDSEKLSPYECGFDPLGSARLPFSIRFFLVAILFLLFDLEIALLLPLPWGIHLDPMLMLTWAFVIIMLLTVGLIYEWLQGGLEWAE

SIPDEB70E2E5001E0F8
type: Transmembrane Annotation
comment: Helical
range: 22861356299597358tt52tt74

22861356299597358tt52
type: Position
type: ExactPosition
position: 52
reference: MNLILTMILISSSISTILAIVAFWLPQMNPDSEKLSPYECGFDPLGSARLPFSIRFFLVAILFLLFDLEIALLLPLPWGIHLDPMLMLTWAFVIIMLLTVGLIYEWLQGGLEWAE

22861356299597358tt74
type: Position
type: ExactPosition
position: 74
reference: MNLILTMILISSSISTILAIVAFWLPQMNPDSEKLSPYECGFDPLGSARLPFSIRFFLVAILFLLFDLEIALLLPLPWGIHLDPMLMLTWAFVIIMLLTVGLIYEWLQGGLEWAE

SIP85786F60159E2229
type: Transmembrane Annotation
comment: Helical
range: 22861356299597358tt86tt107

22861356299597358tt86
type: Position
type: ExactPosition
position: 86
reference: MNLILTMILISSSISTILAIVAFWLPQMNPDSEKLSPYECGFDPLGSARLPFSIRFFLVAILFLLFDLEIALLLPLPWGIHLDPMLMLTWAFVIIMLLTVGLIYEWLQGGLEWAE

22861356299597358tt107
type: Position
type: ExactPosition
position: 107
reference: MNLILTMILISSSISTILAIVAFWLPQMNPDSEKLSPYECGFDPLGSARLPFSIRFFLVAILFLLFDLEIALLLPLPWGIHLDPMLMLTWAFVIIMLLTVGLIYEWLQGGLEWAE

MNLILTMILISSSISTILAIVAFWLPQMNPDSEKLSPYECGFDPLGSARLPFSIRFFLVAILFLLFDLEIALLLPLPWGIHLDPMLMLTWAFVIIMLLTVGLIYEWLQGGLEWAE
type: Simple Sequence
modified: 2003-03-01
version: 1
mass: 13055

Q8HMR8
type: Protein
reviewed: false
created: 2003-03-01
modified: 2022-12-14
version: 79
mnemonic: Q8HMR8_POLSE
citation: http://purl.uniprot.org/citations/12470943
recommended name: SIP01806B802B154B42
organism: http://purl.uniprot.org/taxonomy/178879
encoded in: Mitochondrion
annotation: SIP9DDD6DC1A0494F60
annotation: SIPEF7056CEF7DFB221
annotation: SIPD45A7A7DF21F4095
annotation: SIP1B19083898A51F23
annotation: SIP26734220EF83317B
annotation: SIP00729AE3560DEB7E
annotation: SIP9C6A6C4F5DC950BA
annotation: SIPDF30E7AA61A90201
annotation: SIPCDCE40DE4BE37155
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/66
classified with: http://purl.uniprot.org/keywords/138
classified with: http://purl.uniprot.org/keywords/496
classified with: http://purl.uniprot.org/keywords/1133
classified with: GO_0005743
classified with: GO_0045263
classified with: GO_0015078
classified with: GO_0015986
sequence: Q8HMR8-1

Q8HMR8-citation-12470943
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

IPR000568
type: Resource
database: InterPro
comment: ATP_synth_F0_asu

IPR023011
type: Resource
database: InterPro
comment: ATP_synth_F0_asu_AS

IPR045083
type: Resource
database: InterPro
comment: ATP_synth_F0_asu_bact/mt

IPR035908
type: Resource
database: InterPro
comment: F0_ATP_A_sf

PTHR11410
type: Resource
database: PANTHER
comment: ATP SYNTHASE SUBUNIT A
signature sequence match: PANTHER PTHR11410 match 1

PF00119
type: Resource
database: Pfam
comment: ATP-synt_A
signature sequence match: Pfam PF00119 match 1

PR00123
type: Resource
database: PRINTS
comment: ATPASEA

SSF81336
type: Resource
database: SUPFAM
comment: F1F0 ATP synthase subunit A
signature sequence match: SUPFAM SSF81336 match 1

TIGR01131
type: Resource
database: TIGRFAMs
comment: ATP_synt_6_or_A
signature sequence match: TIGRFAMs TIGR01131 match 1

PS00449
type: Resource
database: PROSITE
comment: ATPASE_A
signature sequence match: PROSITE PS00449 match 1

SIP01806B802B154B42
type: Structured Name
full name: ATP synthase subunit a

ATP6
type: Gene

SIP9DDD6DC1A0494F60
type: Function Annotation
comment: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.

SIPEF7056CEF7DFB221
type: Subunit Annotation
comment: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.

SIP1B19083898A51F23
type: Similarity Annotation
comment: Belongs to the ATPase A chain family.

SIP26734220EF83317B
type: Transmembrane Annotation
comment: Helical
range: 22861356299597870tt12tt31

22861356299597870tt12
type: Position
type: ExactPosition
position: 12
reference: Q8HMR8-1

22861356299597870tt31
type: Position
type: ExactPosition
position: 31
reference: Q8HMR8-1

SIP00729AE3560DEB7E
type: Transmembrane Annotation
comment: Helical
range: 22861356299597870tt69tt89

22861356299597870tt69
type: Position
type: ExactPosition
position: 69
reference: Q8HMR8-1

22861356299597870tt89
type: Position
type: ExactPosition
position: 89
reference: Q8HMR8-1

SIP9C6A6C4F5DC950BA
type: Transmembrane Annotation
comment: Helical
range: 22861356299597870tt138tt158

22861356299597870tt138
type: Position
type: ExactPosition
position: 138
reference: Q8HMR8-1

22861356299597870tt158
type: Position
type: ExactPosition
position: 158
reference: Q8HMR8-1

SIPDF30E7AA61A90201
type: Transmembrane Annotation
comment: Helical
range: 22861356299597870tt170tt190

22861356299597870tt170
type: Position
type: ExactPosition
position: 170
reference: Q8HMR8-1

22861356299597870tt190
type: Position
type: ExactPosition
position: 190
reference: Q8HMR8-1

SIPCDCE40DE4BE37155
type: Transmembrane Annotation
comment: Helical
range: 22861356299597870tt196tt223

22861356299597870tt196
type: Position
type: ExactPosition
position: 196
reference: Q8HMR8-1

22861356299597870tt223
type: Position
type: ExactPosition
position: 223
reference: Q8HMR8-1

Q8HMR8-1
type: Simple Sequence
modified: 2003-03-01
version: 1
mass: 25256
value: MTLTFFDQFASQTFLGIPLIAIALLLPWLLFPTPNKRWMNNRLITIQSWFITRATNQLMLPLNIGAHKWAVVLIALLLFLITLNLLGLLPYTFTPTTQLSMNMALAVPLWLATVLIGMRNQPTHSLAHLLPEGTPTLLIPILIIIETISLFIRPLALGVRLTANLTAGHLLIQLISTATFVMLPIMPTIAMLTLTVLALLTILEIAVAMIQAYVFVLLLSLYLQENV