A0A0B4U412
type: Protein
reviewed: false
created: 2015-04-01
modified: 2022-12-14
version: 41
mnemonic: A0A0B4U412_9HELI
citation: http://purl.uniprot.org/citations/25736414
recommended name: SIPC5431AF593A4DF96
enzyme: http://purl.uniprot.org/enzyme/5.6.2.2
organism: http://purl.uniprot.org/taxonomy/1591088
annotation: SIP9C0AEA746B4549A1
annotation: SIP5935A9560C73A621
annotation: SIPC05DAA2493D2A3AF
annotation: SIP7064A4CBEFEB5E0D
annotation: SIP6AAA62F3201E0E8C
annotation: SIPC71FC0C43C79D2C9
annotation: SIPD9B45E78C5A4FE2B
annotation: SIP4340281A50029A9A
annotation: SIP211C70C2FD286409
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/460
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/799
classified with: GO_0005694
classified with: GO_0005737
classified with: GO_0009330
classified with: GO_0005524
classified with: GO_0003677
classified with: GO_0003918
classified with: GO_0046872
classified with: GO_0006265
classified with: GO_0006261
sequence: A0A0B4U412-1

http://purl.uniprot.org/citations/25736414
type: Journal Citation
title: Helicobacter himalayensis sp. nov. isolated from gastric mucosa of Marmota himalayana.
author: Hu S.
author: Jin D.
author: Lu S.
author: Liu S.
author: Zhang J.
author: Wang Y.
author: Bai X.
author: Xiong Y.
author: Huang Y.
author: Xu H.
author: Wang Y.'
author: Du X.
author: Ye C.
author: Hanninen M.L.
author: Xu J.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/25736414
date: 2015
name: Int. J. Syst. Evol. Microbiol.
volume: 65
pages: 1719-1725

A0A0B4U412-citation-25736414
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

80
type: Strain

cd03366
type: Resource
database: CDD
comment: TOPRIM_TopoIIA_GyrB
signature sequence match: CDD cd03366 match 1

MF_01898
type: Resource
database: HAMAP
comment: GyrB
signature sequence match: HAMAP MF 01898 match 1

IPR002288
type: Resource
database: InterPro
comment: DNA_gyrase_B_C

IPR011557
type: Resource
database: InterPro
comment: GyrB

IPR003594
type: Resource
database: InterPro
comment: HATPase_C

IPR036890
type: Resource
database: InterPro
comment: HATPase_C_sf

IPR020568
type: Resource
database: InterPro
comment: Ribosomal_S5_D2-typ_fold

IPR014721
type: Resource
database: InterPro
comment: Ribosomal_S5_D2-typ_fold_subgr

IPR001241
type: Resource
database: InterPro
comment: Topo_IIA

IPR013760
type: Resource
database: InterPro
comment: Topo_IIA-like_dom_sf

IPR013759
type: Resource
database: InterPro
comment: Topo_IIA_B_C

IPR013506
type: Resource
database: InterPro
comment: Topo_IIA_bsu_dom2

IPR018522
type: Resource
database: InterPro
comment: TopoIIA_CS

IPR006171
type: Resource
database: InterPro
comment: TOPRIM_domain

IPR034160
type: Resource
database: InterPro
comment: TOPRIM_GyrB

PF00204
type: Resource
database: Pfam
comment: DNA_gyraseB
signature sequence match: Pfam PF00204 match 1

PF00986
type: Resource
database: Pfam
comment: DNA_gyraseB_C
signature sequence match: Pfam PF00986 match 1

PF02518
type: Resource
database: Pfam
comment: HATPase_c
signature sequence match: Pfam PF02518 match 1

PF01751
type: Resource
database: Pfam
comment: Toprim
signature sequence match: Pfam PF01751 match 1

SM00387
type: Resource
database: SMART
comment: HATPase_c
signature sequence match: SMART SM00387 match 1

SM00433
type: Resource
database: SMART
comment: TOP2c
signature sequence match: SMART SM00433 match 1

SSF55874
type: Resource
database: SUPFAM
comment: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
signature sequence match: SUPFAM SSF55874 match 1

SSF54211
type: Resource
database: SUPFAM
comment: Ribosomal protein S5 domain 2-like
signature sequence match: SUPFAM SSF54211 match 1

SSF56719
type: Resource
database: SUPFAM
comment: Type II DNA topoisomerase
signature sequence match: SUPFAM SSF56719 match 1

TIGR01059
type: Resource
database: TIGRFAMs
comment: gyrB
signature sequence match: TIGRFAMs TIGR01059 match 1

PS00177
type: Resource
database: PROSITE
comment: TOPOISOMERASE_II
signature sequence match: PROSITE PS00177 match 1

PS50880
type: Resource
database: PROSITE
comment: TOPRIM
signature sequence match: PROSITE PS50880 match 1

SIPC5431AF593A4DF96
type: Structured Name
full name: DNA gyrase subunit B
ec name: 5.6.2.2

gyrB
type: Gene

SIP9C0AEA746B4549A1
type: Function Annotation
comment: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

SIP7064A4CBEFEB5E0D
type: Subunit Annotation
comment: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

SIPC71FC0C43C79D2C9
type: Annotation
comment: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.

SIPD9B45E78C5A4FE2B
type: Similarity Annotation
comment: Belongs to the type II topoisomerase GyrB family.

SIP4340281A50029A9A
type: Similarity Annotation
comment: Belongs to the type II topoisomerase family.

SIP211C70C2FD286409
type: Domain Extent Annotation
comment: Toprim
range: -9218585705633003474tt417tt531

-9218585705633003474tt417
type: Position
type: ExactPosition
position: 417
reference: A0A0B4U412-1

-9218585705633003474tt531
type: Position
type: ExactPosition
position: 531
reference: A0A0B4U412-1

A0A0B4U412-1
type: Simple Sequence
modified: 2015-04-01
version: 1
mass: 88133
value: MQDLPKEYKGSNIKVLKGLEAVRKRPGMYIGDTNIGGLHHMVYEVVDNSIDEAMAGYCTHIRVTLTESGSAIIEDNGRGIPVDMHPTENMPAATVVLTVLHAGGKFDQDSYKVSGGLHGVGVSVVNALSSKLIMTIKKDGNIYRQEFAKGIPQTDLEIIGQTNERGTTIEFFPDSEIMEVLEFNKETLSRRFKEIAYLNKNVTISFYDEHSAFEEIYHFEGGLLQFVQDLNHKPFVSQIITFETLEQDVEVEIALAYNDGYDEKVLSFVNNIRTPEGGTHEAGFRAGLSRAIMAYIDANANAREKDSKITGDDVREGLVAIVSTKVIEPQFEGQTKGKLGSSFVKPIVQKLTYEKISKFFEENPNDAKAIMQKAIMAARGREAAKKARDLTRKKENFSVGTLPGKLADCQSKDPTESEIYLVEGDSAGGSAKQGRDRGYQAILPLRGKILNVEKSRLDKILKSDEIKNMITAFGCGIGEEFNLEKLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLKPLIENGHIYIAQPPLYRFKKGKKEIYLKDEKALSEYLIENGISNFSFEGVGNAELLEILKFISHYRFILKELEKRHSMIEVVKYLIENPHLQTDDYQKLYKDIEEFLQTKQYNILNKVIAQDFLKLYVQTRTGLVELEVNENLWCDSLYEEARFIYEKIKQRDLEFLKDKDMITLLEEIESSAKKDAYIQRYKGLGEMNPEQLWETTMTPTNRTLLRVSLEDDIKADEIFTLFMGDEVEPRRAYIQNHAKDVKHLDV

A0A0B4U5F6
type: Protein
reviewed: false
created: 2015-04-01
modified: 2022-12-14
version: 33
mnemonic: A0A0B4U5F6_9HELI
citation: http://purl.uniprot.org/citations/25736414
recommended name: SIPF255B4347D4E348A
alternative name: SIPE5C33196A30979CA
alternative name: SIPE325E657B082D974
enzyme: http://purl.uniprot.org/enzyme/5.6.1.7
organism: http://purl.uniprot.org/taxonomy/1591088
annotation: SIPA14F8351BC429F3A
annotation: SIP04A490EB0224E16A
annotation: SIP4AF3E65589D2D067
annotation: SIP55D219D13ECE737B
annotation: SIPE254FC32EEA7B630
annotation: SIP7B240259307DEF3F
annotation: SIPE2CA8739AC2C36DE
annotation: SIP4F7E03EF7538F797
annotation: SIPCFDD5E0F24DCF543
annotation: SIPDE0D15A002B388DA
annotation: SIP7305B395ECA8D5EE
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/67
classified with: http://purl.uniprot.org/keywords/143
classified with: http://purl.uniprot.org/keywords/963
classified with: http://purl.uniprot.org/keywords/413
classified with: http://purl.uniprot.org/keywords/346
classified with: GO_0005737
classified with: GO_0005524
classified with: GO_0140662
classified with: GO_0016853
classified with: GO_0051082
classified with: GO_0042026
sequence: A0A0B4U5F6-1

A0A0B4U5F6-citation-25736414
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

80
type: Strain

cd03344
type: Resource
database: CDD
comment: GroEL
signature sequence match: CDD cd03344 match 1

MF_00600
type: Resource
database: HAMAP
comment: CH60
signature sequence match: HAMAP MF 00600 match 1

IPR018370
type: Resource
database: InterPro
comment: Chaperonin_Cpn60_CS

IPR001844
type: Resource
database: InterPro
comment: Cpn60/GroEL

IPR002423
type: Resource
database: InterPro
comment: Cpn60/GroEL/TCP-1

IPR027409
type: Resource
database: InterPro
comment: GroEL-like_apical_dom_sf

IPR027413
type: Resource
database: InterPro
comment: GROEL-like_equatorial_sf

IPR027410
type: Resource
database: InterPro
comment: TCP-1-like_intermed_sf

PF00118
type: Resource
database: Pfam
comment: Cpn60_TCP1
signature sequence match: Pfam PF00118 match 1

PR00298
type: Resource
database: PRINTS
comment: CHAPERONIN60

SSF52029
type: Resource
database: SUPFAM
comment: GroEL apical domain-like
signature sequence match: SUPFAM SSF52029 match 1

SSF48592
type: Resource
database: SUPFAM
comment: GroEL equatorial domain-like
signature sequence match: SUPFAM SSF48592 match 1
signature sequence match: SUPFAM SSF48592 match 2

TIGR02348
type: Resource
database: TIGRFAMs
comment: GroEL
signature sequence match: TIGRFAMs TIGR02348 match 1

PS00296
type: Resource
database: PROSITE
comment: CHAPERONINS_CPN60
signature sequence match: PROSITE PS00296 match 1

SIPF255B4347D4E348A
type: Structured Name
full name: Chaperonin GroEL
ec name: 5.6.1.7

SIPE5C33196A30979CA
type: Structured Name
full name: 60 kDa chaperonin

SIPE325E657B082D974
type: Structured Name
full name: Chaperonin-60
short name: Cpn60

hsp60
type: Gene
alternative label: groEL
alternative label: groL

SIPA14F8351BC429F3A
type: Function Annotation
comment: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

SIP4AF3E65589D2D067
type: Subunit Annotation
comment: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.

SIPE254FC32EEA7B630
type: Similarity Annotation
comment: Belongs to the chaperonin (HSP60) family.

SIP7B240259307DEF3F
type: Caution Annotation
comment: Lacks conserved residue(s) required for the propagation of feature annotation.

-9218585705631606738tt30
type: Position
type: ExactPosition
position: 30
reference: A0A0B4U5F6-1

-9218585705631606738tt33
type: Position
type: ExactPosition
position: 33
reference: A0A0B4U5F6-1

-9218585705631606738tt51
type: Position
type: ExactPosition
position: 51
reference: A0A0B4U5F6-1

-9218585705631606738tt87
type: Position
type: ExactPosition
position: 87
reference: A0A0B4U5F6-1

-9218585705631606738tt91
type: Position
type: ExactPosition
position: 91
reference: A0A0B4U5F6-1

-9218585705631606738tt414
type: Position
type: ExactPosition
position: 414
reference: A0A0B4U5F6-1

-9218585705631606738tt492
type: Position
type: ExactPosition
position: 492
reference: A0A0B4U5F6-1

A0A0B4U5F6-1
type: Simple Sequence
modified: 2015-04-01
version: 1
mass: 57363
value: MANKEIHFSDSARNKLYEGIKQLNDAVKVTMGPRGRNVLIQKSYGAPAITKDGVSVAKEVELADPIANMGAQLVKEVASKTADAAGDGTTTATVLAHSIFKEGLRNITAGANPVEVKRGMDKAAEAIIEELKKGSKKVSGSEIAQVATISANSDEAVGKLIAEAMEKVGKDGVITVEEAKGINDELSVVEGMQFDRGYLSAYFVTNTEKMIAQLENAYVLLTDKKISSMKEILPLLEATMQSGKPLLIIAEDIEGEALTTLVVNKLRGVLNVSAVKAPGFGDRRKAMLQDIAILTGGQVISEELGKTLEAASLQDLGQAARVVIDKDNTTIVDGKGKAQEVKDRIAQIRTEIANTTSDYDKEKLQERLAKLSGGVAVIKVGAATEVEMKEKKDRVDDALSATKAAVDEGIVIGGGAALIHAAQKVKLKLEGDEAVGYDIIKRAIKAPLAQIATNAGFDSGVVVNEVEKGKETIGFNASKGEYVDMFKAGIIDPLKVTRIALQNAVSVSSLLLTTEATINEIKEDKPAPAMPDMGGMGGMGGMM