Q01640
type: Protein
reviewed: true
created: 1993-04-01
modified: 2022-08-03
version: 89
mnemonic: NEP_INCAA
old mnemonic: VNS2_INCAA
replaces: A7BHX7
citation: http://purl.uniprot.org/citations/17537859
citation: http://purl.uniprot.org/citations/2943076
citation: http://purl.uniprot.org/citations/10900030
conflicting sequence: SIP5F3BF3C08835F469
recommended name: SIPB6A217B62593E5D8
alternative name: SIP6826166B2087F1E5
organism: http://purl.uniprot.org/taxonomy/11553
annotation: SIPFF206F70FCD8332B
annotation: SIPD9476876FCC30DAD
annotation: SIPF0325623EF6EF2E7
annotation: SIP3BF8C2348DDDA6DF
annotation: SIPA64D40DC7BB20475
annotation: SIPF9A8146C3C8FAB73
annotation: PRO_0000079017
annotation: SIPE7BF0C5429177CF4
annotation: SIP4D1B75EED7FE70B9
annotation: SIP5046C6E34E5052B9
existence: Evidence at Transcript Level Existence
classified with: http://purl.uniprot.org/keywords/25
classified with: http://purl.uniprot.org/keywords/1048
classified with: http://purl.uniprot.org/keywords/945
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/813
classified with: http://purl.uniprot.org/keywords/946
classified with: GO_0042025
classified with: GO_0044423
classified with: GO_0039675
sequence: MSDKTVKSTNLMAFVATKMLERQEDLDTCTEMQVEKMKTSTKARLKTESSFAPRTWEDAIKDEILRRSVDTSSLDKWPELKQELENVSDALKADSLWLPMKSLSLYSKVSNQEPSSIPIGEMKHQILTRLKLICSRLEKLDLNLSKAVLGIQNSEDLILIIYNRDVCKNTILMIKSLCNSLI
sequence: Q01639-1
proteome: Genome

http://purl.uniprot.org/citations/17537859
type: Journal Citation
title: A mutation on influenza C virus M1 protein affects virion morphology by altering the membrane affinity of the protein.
author: Muraki Y.
author: Murata T.
author: Takashita E.
author: Matsuzaki Y.
author: Sugawara K.
author: Hongo S.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/17537859
date: 2007
name: J. Virol.
volume: 81
pages: 8766-8773

Q01640-citation-17537859
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA]

http://purl.uniprot.org/citations/2943076
type: Journal Citation
title: Epidemiology of influenza C virus in man: multiple evolutionary lineages and low rate of change.
author: Buonagurio D.A.
author: Nakada S.
author: Fitch W.M.
author: Palese P.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/2943076
date: 1986
name: Virology
volume: 153
pages: 12-21

Q01640-citation-2943076
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 6-182

http://purl.uniprot.org/citations/10900030
type: Journal Citation
title: Phylogenetic analysis of influenza C virus nonstructural (NS) protein genes and identification of the NS2 protein.
author: Alamgir A.S.M.
author: Matsuzaki Y.
author: Hongo S.
author: Tsuchiya E.
author: Sugawara K.
author: Muraki Y.
author: Nakamura K.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/10900030
date: 2000
name: J. Gen. Virol.
volume: 81
pages: 1933-1940

Q01640-citation-10900030
type: Citation Statement
scope: IDENTIFICATION OF FRAMESHIFT

EMBL BAA24045.1
comment: Frameshift.

MF_04067
type: Resource
database: HAMAP
comment: INFV_NEP
signature sequence match: HAMAP MF 04067 match 1

IPR005188
type: Resource
database: InterPro
comment: Flu_C_NS2

IPR000968
type: Resource
database: InterPro
comment: Flu_NS2

PF03555
type: Resource
database: Pfam
comment: Flu_C_NS2
signature sequence match: Pfam PF03555 match 1

SIPB6A217B62593E5D8
type: Structured Name
full name: Nuclear export protein
short name: NEP

SIP6826166B2087F1E5
type: Structured Name
full name: Non-structural protein 2
short name: NS2

NS
type: Gene

SIPFF206F70FCD8332B
type: Function Annotation
comment: Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs bound to the protein M1. Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced.

SIPD9476876FCC30DAD
type: Subunit Annotation
comment: Interacts with protein M1. May interact with host nucleoporin RAB/HRB and exportin XPO1/CRM1.

SIPA64D40DC7BB20475
type: Similarity Annotation
comment: Belongs to the influenza viruses NEP family.

PRO_0000079017
type: Chain Annotation
comment: Nuclear export protein
mass: 20768
range: 22852461034483758tt1tt182

22852461034483758tt1
type: Position
type: ExactPosition
position: 1
reference: MSDKTVKSTNLMAFVATKMLERQEDLDTCTEMQVEKMKTSTKARLKTESSFAPRTWEDAIKDEILRRSVDTSSLDKWPELKQELENVSDALKADSLWLPMKSLSLYSKVSNQEPSSIPIGEMKHQILTRLKLICSRLEKLDLNLSKAVLGIQNSEDLILIIYNRDVCKNTILMIKSLCNSLI

22852461034483758tt182
type: Position
type: ExactPosition
position: 182
reference: MSDKTVKSTNLMAFVATKMLERQEDLDTCTEMQVEKMKTSTKARLKTESSFAPRTWEDAIKDEILRRSVDTSSLDKWPELKQELENVSDALKADSLWLPMKSLSLYSKVSNQEPSSIPIGEMKHQILTRLKLICSRLEKLDLNLSKAVLGIQNSEDLILIIYNRDVCKNTILMIKSLCNSLI

SIPE7BF0C5429177CF4
type: Motif Annotation
comment: Nuclear export signal
range: 22852461034483758tt96tt105

22852461034483758tt96
type: Position
type: ExactPosition
position: 96
reference: MSDKTVKSTNLMAFVATKMLERQEDLDTCTEMQVEKMKTSTKARLKTESSFAPRTWEDAIKDEILRRSVDTSSLDKWPELKQELENVSDALKADSLWLPMKSLSLYSKVSNQEPSSIPIGEMKHQILTRLKLICSRLEKLDLNLSKAVLGIQNSEDLILIIYNRDVCKNTILMIKSLCNSLI

22852461034483758tt105
type: Position
type: ExactPosition
position: 105
reference: MSDKTVKSTNLMAFVATKMLERQEDLDTCTEMQVEKMKTSTKARLKTESSFAPRTWEDAIKDEILRRSVDTSSLDKWPELKQELENVSDALKADSLWLPMKSLSLYSKVSNQEPSSIPIGEMKHQILTRLKLICSRLEKLDLNLSKAVLGIQNSEDLILIIYNRDVCKNTILMIKSLCNSLI

SIP4D1B75EED7FE70B9
type: Motif Annotation
comment: Nuclear export signal
range: 22852461034483758tt122tt132

22852461034483758tt122
type: Position
type: ExactPosition
position: 122
reference: MSDKTVKSTNLMAFVATKMLERQEDLDTCTEMQVEKMKTSTKARLKTESSFAPRTWEDAIKDEILRRSVDTSSLDKWPELKQELENVSDALKADSLWLPMKSLSLYSKVSNQEPSSIPIGEMKHQILTRLKLICSRLEKLDLNLSKAVLGIQNSEDLILIIYNRDVCKNTILMIKSLCNSLI

22852461034483758tt132
type: Position
type: ExactPosition
position: 132
reference: MSDKTVKSTNLMAFVATKMLERQEDLDTCTEMQVEKMKTSTKARLKTESSFAPRTWEDAIKDEILRRSVDTSSLDKWPELKQELENVSDALKADSLWLPMKSLSLYSKVSNQEPSSIPIGEMKHQILTRLKLICSRLEKLDLNLSKAVLGIQNSEDLILIIYNRDVCKNTILMIKSLCNSLI

SIP5046C6E34E5052B9
type: Natural Variant Annotation
substitution: T
range: 22852461034483758tt169tt169

22852461034483758tt169
type: Position
type: ExactPosition
position: 169
reference: MSDKTVKSTNLMAFVATKMLERQEDLDTCTEMQVEKMKTSTKARLKTESSFAPRTWEDAIKDEILRRSVDTSSLDKWPELKQELENVSDALKADSLWLPMKSLSLYSKVSNQEPSSIPIGEMKHQILTRLKLICSRLEKLDLNLSKAVLGIQNSEDLILIIYNRDVCKNTILMIKSLCNSLI

MSDKTVKSTNLMAFVATKMLERQEDLDTCTEMQVEKMKTSTKARLKTESSFAPRTWEDAIKDEILRRSVDTSSLDKWPELKQELENVSDALKADSLWLPMKSLSLYSKVSNQEPSSIPIGEMKHQILTRLKLICSRLEKLDLNLSKAVLGIQNSEDLILIIYNRDVCKNTILMIKSLCNSLI
type: Simple Sequence
modified: 2011-04-05
version: 3
mass: 20768
name: NEP
name: NS2
type: External Sequence

Q01639-1
type: External Sequence
name: NS1
type: Simple Sequence
modified: 2006-02-21
version: 2
mass: 27752
value: MSDKTVKSTNLMAFVATKMLERQEDLDTCTEMQVEKMKTSTKARLRTESSFAPRTWEDAIKDGELLFNGTILQTESPTMTPASVEMKGKKFPIDFAPSNIAPIGQNPIYLSPCIPNFDGNVWEATMYHHRGATLTKTMNCNCFQRTIWCHPNPSRMRLSYAFVLYCRNTKKICGYLIAKQVAGIETGIRKCFRCIKSGFVMATDEISLTILQSIKSGAQLDPYWGNEKPDIDKTEAYMLSLREAGP

http://purl.uniprot.org/uniprot/Q01640#attribution-EA5776F9A1D5228ADA3026FC1CB4D23D
manual: true
evidence: ECO_0000255
source: MF_04067

http://purl.uniprot.org/uniprot/Q01640#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

Q01639
type: Protein
reviewed: true
created: 1993-04-01
modified: 2022-12-14
version: 79
mnemonic: NS1_INCAA
old mnemonic: VNS1_INCAA
old mnemonic: VNST_INCAA
replaces: A7BHX8
replaces: Q9YMF4
replaces: Q9YMF5
citation: http://purl.uniprot.org/citations/9918879
citation: http://purl.uniprot.org/citations/17537859
citation: http://purl.uniprot.org/citations/2943076
citation: http://purl.uniprot.org/citations/10900030
conflicting sequence: SIPD54BD1173C13277D
recommended name: SIP3404E85556CD52B3
alternative name: SIPB28E009E50C9FC0E
organism: http://purl.uniprot.org/taxonomy/11553
annotation: SIP08DA3A401AFC6F09
annotation: SIPAE924A2D96BB523B
annotation: SIPA13BCED1EC27B058
annotation: SIPB33924BA03CD4065
annotation: SIP091BC37CFEEC55B5
annotation: SIPC7801264A6E3E8B4
annotation: SIP7AD49132B5952384
annotation: PRO_0000044588
annotation: SIP1812E0B7F156CBF8
annotation: SIPD0AB6191DB48D285
annotation: SIP38EEF853076669E6
annotation: SIP86B5CE9B84DDEC16
annotation: SIP6C77BD8CC7BCCCF1
annotation: SIP260BDBDBA5A26293
annotation: SIPF8F5E0326ED64A79
annotation: SIP6F700222FD44D5B9
annotation: SIP65AD28D6806CAD63
annotation: SIPEC5B1A54EC54B0B1
existence: Evidence at Transcript Level Existence
classified with: http://purl.uniprot.org/keywords/25
classified with: http://purl.uniprot.org/keywords/1035
classified with: http://purl.uniprot.org/keywords/1048
classified with: http://purl.uniprot.org/keywords/1114
classified with: http://purl.uniprot.org/keywords/1088
classified with: http://purl.uniprot.org/keywords/922
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/694
classified with: GO_0030430
classified with: GO_0042025
classified with: GO_0003723
classified with: GO_0039502
classified with: GO_0039540
sequence: Q01639-1
sequence: MSDKTVKSTNLMAFVATKMLERQEDLDTCTEMQVEKMKTSTKARLKTESSFAPRTWEDAIKDEILRRSVDTSSLDKWPELKQELENVSDALKADSLWLPMKSLSLYSKVSNQEPSSIPIGEMKHQILTRLKLICSRLEKLDLNLSKAVLGIQNSEDLILIIYNRDVCKNTILMIKSLCNSLI
proteome: Genome

http://purl.uniprot.org/citations/9918879
type: Journal Citation
title: The ORF, regulated synthesis, and persistence-specific variation of influenza C viral NS1 protein.
author: Marschall M.
author: Helten A.
author: Hechtfischer A.
author: Zach A.
author: Banaschewski C.
author: Hell W.
author: Meier-Ewert H.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/9918879
date: 1999
name: Virology
volume: 253
pages: 208-218

Q01639-citation-9918879
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA]
scope: SUBCELLULAR LOCATION
scope: IDENTIFICATION OF FRAMESHIFT

C/Ann Arbor/1/50-pi
type: Strain

Wild-type
type: Strain

Q01639-citation-17537859
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [MRNA]

Q01639-citation-2943076
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 6-241

Q01639-citation-10900030
type: Citation Statement
scope: IDENTIFICATION OF FRAMESHIFT

EMBL BAA24044.1
comment: Frameshift.

Q01639
type: Resource
database: IntAct
comment: 1

MF_04066
type: Resource
database: HAMAP
comment: INFV_NS1
signature sequence match: HAMAP MF 04066 match 1

IPR005187
type: Resource
database: InterPro
comment: Flu_C_NS1

IPR004208
type: Resource
database: InterPro
comment: NS1

PF03506
type: Resource
database: Pfam
comment: Flu_C_NS1
signature sequence match: Pfam PF03506 match 1

SIP3404E85556CD52B3
type: Structured Name
full name: Non-structural protein 1
short name: NS1

SIPB28E009E50C9FC0E
type: Structured Name
full name: NS1A

NS
type: Gene

SIP08DA3A401AFC6F09
type: Function Annotation
comment: Prevents the establishment of the cellular antiviral state initiated by host RIGI, which normally triggers the antiviral transduction signal that leads to the activation of type I IFN genes by transcription factors IRF3 and IRF7. Participates also in the up-regulation of the splicing of viral mRNAs.

SIPB33924BA03CD4065
type: PTM Annotation
comment: The NS1 protein of strain C/Ann Arbor/1/50-pi is phosphorylated.

SIP091BC37CFEEC55B5
type: Annotation
comment: The strain C/Ann Arbor/1/50-pi causes persistent infection.

SIPC7801264A6E3E8B4
type: Similarity Annotation
comment: Belongs to the influenza C viruses NS1 family.

PRO_0000044588
type: Chain Annotation
comment: Non-structural protein 1
mass: 27752
range: 22852461034420526tt1tt246

22852461034420526tt1
type: Position
type: ExactPosition
position: 1
reference: Q01639-1

22852461034420526tt246
type: Position
type: ExactPosition
position: 246
reference: Q01639-1

SIP1812E0B7F156CBF8
type: Natural Variant Annotation
comment: In strain: C/Ann Arbor/1/50-pi.
substitution: K
range: 22852461034420526tt39tt39

22852461034420526tt39
type: Position
type: ExactPosition
position: 39
reference: Q01639-1

SIPD0AB6191DB48D285
type: Natural Variant Annotation
substitution: K
range: 22852461034420526tt46tt46

22852461034420526tt46
type: Position
type: ExactPosition
position: 46
reference: Q01639-1

SIP38EEF853076669E6
type: Natural Variant Annotation
substitution: A
range: 22852461034420526tt74tt74

22852461034420526tt74
type: Position
type: ExactPosition
position: 74
reference: Q01639-1

SIP86B5CE9B84DDEC16
type: Natural Variant Annotation
comment: In strain: C/Ann Arbor/1/50-pi.
substitution: I
range: 22852461034420526tt84tt84

22852461034420526tt84
type: Position
type: ExactPosition
position: 84
reference: Q01639-1

SIP6C77BD8CC7BCCCF1
type: Natural Variant Annotation
comment: In strain: C/Ann Arbor/1/50-pi.
substitution: T
range: 22852461034420526tt96tt96

22852461034420526tt96
type: Position
type: ExactPosition
position: 96
reference: Q01639-1

SIP260BDBDBA5A26293
type: Natural Variant Annotation
substitution: R
range: 22852461034420526tt98tt98

22852461034420526tt98
type: Position
type: ExactPosition
position: 98
reference: Q01639-1

SIPF8F5E0326ED64A79
type: Natural Variant Annotation
substitution: R
range: 22852461034420526tt179tt179

22852461034420526tt179
type: Position
type: ExactPosition
position: 179
reference: Q01639-1

SIP6F700222FD44D5B9
type: Natural Variant Annotation
comment: In strain: C/Ann Arbor/1/50-pi.
substitution: K
range: 22852461034420526tt189tt189

22852461034420526tt189
type: Position
type: ExactPosition
position: 189
reference: Q01639-1

SIP65AD28D6806CAD63
type: Natural Variant Annotation
substitution: T
range: 22852461034420526tt228tt228

22852461034420526tt228
type: Position
type: ExactPosition
position: 228
reference: Q01639-1

SIPEC5B1A54EC54B0B1
type: Natural Variant Annotation
comment: In strain: C/Ann Arbor/1/50-pi.
substitution: N
range: 22852461034420526tt232tt232

22852461034420526tt232
type: Position
type: ExactPosition
position: 232
reference: Q01639-1

http://purl.uniprot.org/uniprot/Q01639#attribution-8D1C359D4238D9CF807729E5AF55CF34
manual: true
evidence: ECO_0000255
source: MF_04066

http://purl.uniprot.org/uniprot/Q01639#attribution-9DFC624A6AAFE10189130EA5CF234EDF
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/9918879

Q6I7C4
type: Protein
reviewed: true
created: 2006-12-12
modified: 2022-12-14
version: 73
mnemonic: PB2_INCAA
replaces: Q82668
citation: http://purl.uniprot.org/citations/8607283
citation: http://purl.uniprot.org/citations/15218173
conflicting sequence: SIP9A1B4CD7CB43C798
recommended name: SIPFE6DEA0305351DBB
alternative name: SIP714B68F381B8B0EE
organism: http://purl.uniprot.org/taxonomy/11553
annotation: SIP18E9271BC5A9F991
annotation: SIP4E121F57CB81032A
annotation: SIPBF5B6FE148BBB70E
annotation: SIPF08927E89CD32449
annotation: PRO_0000269454
annotation: SIPEA2A040294EDB438
annotation: SIPF689135183AF930A
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/1157
classified with: http://purl.uniprot.org/keywords/1048
classified with: http://purl.uniprot.org/keywords/1104
classified with: http://purl.uniprot.org/keywords/506
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/1195
classified with: http://purl.uniprot.org/keywords/946
classified with: GO_0042025
classified with: GO_0044423
classified with: GO_0003723
classified with: GO_0003968
classified with: GO_0006370
classified with: GO_0075526
classified with: GO_0006351
classified with: GO_0039523
classified with: GO_0039694
sequence: Q6I7C4-1
proteome: Genome

http://purl.uniprot.org/citations/8607283
type: Journal Citation
title: The persistent variant of influenza C virus carries one characteristic point mutation in RNA segment 1.
author: Lapatschek M.S.
author: Marschall M.
author: Meier-Ewert H.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/8607283
date: 1995
name: Virus Res.
volume: 39
pages: 47-54

Q6I7C4-citation-8607283
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC RNA]

http://purl.uniprot.org/citations/15218173
type: Journal Citation
title: Identification of an amino acid residue on influenza C virus M1 protein responsible for formation of the cord-like structures of the virus.
author: Muraki Y.
author: Washioka H.
author: Sugawara K.
author: Matsuzaki Y.
author: Takashita E.
author: Hongo S.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/15218173
date: 2004
name: J. Gen. Virol.
volume: 85
pages: 1885-1893

Q6I7C4-citation-15218173
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC RNA]

MF_04062
type: Resource
database: HAMAP
comment: INV_PB2
signature sequence match: HAMAP MF 04062 match 1

IPR001591
type: Resource
database: InterPro
comment: INV_PB2

PF00604
type: Resource
database: Pfam
comment: Flu_PB2
signature sequence match: Pfam PF00604 match 1

SIPFE6DEA0305351DBB
type: Structured Name
full name: Polymerase basic protein 2

SIP714B68F381B8B0EE
type: Structured Name
full name: RNA-directed RNA polymerase subunit P3

PB2
type: Gene

SIP18E9271BC5A9F991
type: Function Annotation
comment: Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds a wide range of cap structures of target pre-RNAs which are subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.

SIP4E121F57CB81032A
type: Subunit Annotation
comment: Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). Interacts with nucleoprotein NP (via N-terminus).

SIPF08927E89CD32449
type: Similarity Annotation
comment: Belongs to the influenza viruses PB2 family.

PRO_0000269454
type: Chain Annotation
comment: Polymerase basic protein 2
mass: 87843
range: 22859161201226798tt1tt774

22859161201226798tt1
type: Position
type: ExactPosition
position: 1
reference: Q6I7C4-1

22859161201226798tt774
type: Position
type: ExactPosition
position: 774
reference: Q6I7C4-1

SIPEA2A040294EDB438
type: Sequence Conflict Annotation
conflicting sequence: SIP9A1B4CD7CB43C798
substitution: I
range: 22859161201226798tt266tt266

22859161201226798tt266
type: Position
type: ExactPosition
position: 266
reference: Q6I7C4-1

SIPF689135183AF930A
type: Sequence Conflict Annotation
conflicting sequence: SIP9A1B4CD7CB43C798
substitution: Q
range: 22859161201226798tt330tt330

22859161201226798tt330
type: Position
type: ExactPosition
position: 330
reference: Q6I7C4-1

Q6I7C4-1
type: Simple Sequence
modified: 2004-07-19
version: 1
mass: 87843
value: MSFLLTIAKEYKRLCQDAKAAQMMTVGTVSNYTTFKKWTTSRKEKNPSLRMRWAMSSKFPIIANKRMLEEAQIPKEHNNVALWEDTEDVSKRDHVLASASCINYWNFCGPCVNNSEVIKEVYKSRFGRLERRKEIMWKELRFTLVDRQRRRVDTQPVEQRLRTGEIKDLQMWTLFEDEAPLASKFILDNYGLVKEMRSKFANKPLNKEVVAHMLEKQFNPESRFLPVFGAIRPERMELIHALGGETWIQEANTAGISNVDQRKNDMRAVCRKVCLAANASIMNAKSKLVEYIKSTSMRIGETERKLEELILETDDVSPEVTLCKSALGGPLGKTLSFGPMLLKKISGSGVKVKDTVYIQGVRAVQFEYWSEQEEFYGEYKSATALFSRKERSLEWITIGGGINEDRKRLLAMCMIFCRDGDYFKDAPATITMADLSTKLGREIPYQYVMMNWIQKSEDNLEALLYSRGIVETNPGKMGSSMGIDGSKRAIKSLRAVTIQSGKIDMPESKEKIHLELSDNLEAFDSSGRIVATILDLPSDKKVTFQDVSFQHPDLAVLRDEKTAITKGYEALIKRLGTGDNDIPSLIAKKDYLSLYNLPEVKLMAPLIRPNRKGVYSRVARKLVSTQVTTGHYSLHELIKVLPFTYFAPKQGMFEGRLFFSNDSFVEPGVNNNVFSWSKADSSKIYCHGIAIRVPLVVGDEHMDTSLALLEGFSVCENDPRAPMVTRQDLIDVGFGQKVRLFVGQGSVRTFKRTASQRAASSDVNKNVKKIKMSN

http://purl.uniprot.org/uniprot/Q6I7C4#attribution-076B4BA6A2AE21AE49E77971C4D2B16E
manual: true
evidence: ECO_0000255
source: MF_04062

Q6I7C0
type: Protein
reviewed: true
created: 2006-12-12
modified: 2022-10-12
version: 67
mnemonic: NCAP_INCAA
citation: http://purl.uniprot.org/citations/15218173
recommended name: SIP5753F899DCD884A4
alternative name: SIP17DEA91F53865CA7
organism: http://purl.uniprot.org/taxonomy/11553
annotation: SIPBAE0783DFBEC6FA2
annotation: SIPBB5B0B24C37243F6
annotation: SIPA59CC502FBA81BE5
annotation: SIPA875594DE2999A2E
annotation: SIP7C9C039D083BDBFA
annotation: PRO_0000269456
annotation: SIPC76260DF9C736A59
annotation: SIP21C804CD98C47838
annotation: SIPFCEC26EADB7DEDA4
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/1139
classified with: http://purl.uniprot.org/keywords/1048
classified with: http://purl.uniprot.org/keywords/945
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/687
classified with: http://purl.uniprot.org/keywords/694
classified with: http://purl.uniprot.org/keywords/543
classified with: http://purl.uniprot.org/keywords/1163
classified with: GO_0019029
classified with: GO_0042025
classified with: GO_1990904
classified with: GO_0019013
classified with: GO_0003723
classified with: GO_0005198
classified with: GO_0046718
classified with: GO_0075732
sequence: Q6I7C0-1
proteome: Genome

Q6I7C0-citation-15218173
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC RNA]

MF_04070
type: Resource
database: HAMAP
comment: INFV_NCAP
signature sequence match: HAMAP MF 04070 match 1

IPR002141
type: Resource
database: InterPro
comment: Flu_NP

PF00506
type: Resource
database: Pfam
comment: Flu_NP
signature sequence match: Pfam PF00506 match 1

SIP5753F899DCD884A4
type: Structured Name
full name: Nucleoprotein

SIP17DEA91F53865CA7
type: Structured Name
full name: Nucleocapsid protein
short name: Protein N

NP
type: Gene

SIPBAE0783DFBEC6FA2
type: Function Annotation
comment: Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway. Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.

SIPBB5B0B24C37243F6
type: Subunit Annotation
comment: Homomultimerizes to form the nucleocapsid. May bind host exportin-1/XPO1. Binds to viral genomic RNA. Protein-RNA contacts are mediated by a combination of electrostatic interactions between positively charged residues and the phosphate backbone and planar interactions between aromatic side chains and bases.

SIPA875594DE2999A2E
type: PTM Annotation
comment: Late in virus-infected cells, may be cleaved from a 56-kDa protein to a 53-kDa protein by a cellular caspase. This cleavage might be a marker for the onset of apoptosis in infected cells or have a specific function in virus host interaction.

SIP7C9C039D083BDBFA
type: Similarity Annotation
comment: Belongs to the influenza viruses nucleoprotein family.

PRO_0000269456
type: Chain Annotation
comment: Nucleoprotein
mass: 63625
range: 22859161201225774tt1tt565

22859161201225774tt1
type: Position
type: ExactPosition
position: 1
reference: Q6I7C0-1

22859161201225774tt565
type: Position
type: ExactPosition
position: 565
reference: Q6I7C0-1

SIPC76260DF9C736A59
type: Region Annotation
comment: Disordered
range: 22859161201225774tt520tt565

22859161201225774tt520
type: Position
type: ExactPosition
position: 520
reference: Q6I7C0-1

SIP21C804CD98C47838
type: Compositional Bias Annotation
comment: Basic and acidic residues
range: 22859161201225774tt525tt545

22859161201225774tt525
type: Position
type: ExactPosition
position: 525
reference: Q6I7C0-1

22859161201225774tt545
type: Position
type: ExactPosition
position: 545
reference: Q6I7C0-1

SIPFCEC26EADB7DEDA4
type: Compositional Bias Annotation
comment: Polar residues
range: 22859161201225774tt550tt565

22859161201225774tt550
type: Position
type: ExactPosition
position: 550
reference: Q6I7C0-1

Q6I7C0-1
type: Simple Sequence
modified: 2004-07-19
version: 1
mass: 63625
value: MSDRRQNRKTPDEQRKANALIINENIEAYIAICKEVGLNGDEMLILENGIAIEKAIRICCDGKYQEKREKKAREAQRADSNFNADSIGIRLVKRAGSGTNITYHAVVELTSRSRIVQILKSHWGNELNRAKIAGKRLGFSALFASNLEAIIYQRGRNAARRNGSAELFTLTQGAGIETRYKWIMEKHIGIGVLIADAKGLINGKREGKRGVDANVKLRAGTTGSPLERAMQGIEKKAFPGPLRALARRVVKANYNDAREALNVIAEASLLLKPQITNKMTMPWCMWLAARLTLKDEFANFCAYAGRRAFEVFNIAMEKIGICSFQGTIMNDDEIESIEDKAQVLMMACFGLAYEDFSLVSAMVSHPLKLRNRMKIGNFRVGEKVSTVLSPLLRFTRWAEFAQRFALQANTSREGAQISNSAVFAVERKITTDVQRVEELLNKVQAHEDEPLQTLYKKVREQISIIGRNKSEIKEFLGSSMYDLNDQEKQNPINFRSGAHPFFFEFDPDYNPIRVKRPKKPIAKRNSNISRLEEEGMDENSEIGQAKKMKPLDQLTSTSSNIPGKN

http://purl.uniprot.org/uniprot/Q6I7C0#attribution-7728F6D28B3F4DBEF0D6226EF12016BB
manual: true
evidence: ECO_0000255
source: MF_04070

Q6I7C2
type: Protein
reviewed: true
created: 2006-12-12
modified: 2022-10-12
version: 57
mnemonic: PA_INCAA
citation: http://purl.uniprot.org/citations/15218173
recommended name: SIP51B5B3553E2F684D
alternative name: SIPD08BE1A411A843DE
enzyme: http://purl.uniprot.org/enzyme/3.1.-.-
organism: http://purl.uniprot.org/taxonomy/11553
annotation: SIP38ABDA92635230B9
annotation: SIP49923CA70BB46A21
annotation: SIPA842647B656271B8
annotation: SIP935FD56C38E0EC23
annotation: SIP36DD1681F349468A
annotation: SIP8E33F15D180E1EFB
annotation: SIP28FD7C317FEBDBDB
annotation: PRO_0000269453
annotation: SIPF2120C1CFAC5176D
annotation: SIP77B50591A2758899
annotation: SIP5E57E9769172CE1F
annotation: SIP5A04AE08D363049B
annotation: SIP5E907605C806616D
annotation: SIPA2AC73128F07E7BB
annotation: SIP99D986B0AA97E927
annotation: SIP358A21A2D0A856C6
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/1157
classified with: http://purl.uniprot.org/keywords/255
classified with: http://purl.uniprot.org/keywords/1035
classified with: http://purl.uniprot.org/keywords/1048
classified with: http://purl.uniprot.org/keywords/1104
classified with: http://purl.uniprot.org/keywords/464
classified with: http://purl.uniprot.org/keywords/479
classified with: http://purl.uniprot.org/keywords/597
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/688
classified with: GO_0030430
classified with: GO_0042025
classified with: GO_0004519
classified with: GO_0046872
classified with: GO_0003723
classified with: GO_0075526
classified with: GO_0006351
classified with: GO_0039523
classified with: GO_0039694
sequence: Q6I7C2-1
sequence: Q6I7C2-2
proteome: Genome

Q6I7C2-citation-15218173
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC RNA]

MF_04063
type: Resource
database: HAMAP
comment: INFV_PA
signature sequence match: HAMAP MF 04063 match 1

IPR037534
type: Resource
database: InterPro
comment: INFV_PA

IPR001009
type: Resource
database: InterPro
comment: PA/PA-X

IPR038372
type: Resource
database: InterPro
comment: PA/PA-X_sf

PF00603
type: Resource
database: Pfam
comment: Flu_PA
signature sequence match: Pfam PF00603 match 1

SIP51B5B3553E2F684D
type: Structured Name
full name: Polymerase acidic protein
ec name: 3.1.-.-

SIPD08BE1A411A843DE
type: Structured Name
full name: RNA-directed RNA polymerase subunit P2

PA
type: Gene
alternative label: P3

SIP38ABDA92635230B9
type: Function Annotation
comment: Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.

SIP49923CA70BB46A21
type: Cofactor Annotation
comment: Binds 2 manganese ions per subunit.
cofactor: CHEBI_29035

SIPA842647B656271B8
type: Subunit Annotation
comment: Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via C-terminus) with PB1 (via N-terminus).

SIP935FD56C38E0EC23
type: Subcellular Location Annotation
comment: PB1 and PA are transported in the host nucleus as a complex.
located in: SIP97BB0F00D6A8A5FE
located in: SIP5DADC3FB1A7228AC

SIP8E33F15D180E1EFB
type: PTM Annotation
comment: Phosphorylated on serines and threonines by host kinases, including human casein kinase II.

SIP28FD7C317FEBDBDB
type: Similarity Annotation
comment: Belongs to the influenza viruses PA family.

PRO_0000269453
type: Chain Annotation
comment: Polymerase acidic protein
mass: 81881
range: 22859161201226286tt1tt709

22859161201226286tt1
type: Position
type: ExactPosition
position: 1
reference: Q6I7C2-1

22859161201226286tt709
type: Position
type: ExactPosition
position: 709
reference: Q6I7C2-1

SIPF2120C1CFAC5176D
type: Motif Annotation
comment: Nuclear localization signal 1 (NLS1)
range: 22859161201226286tt109tt124

22859161201226286tt109
type: Position
type: ExactPosition
position: 109
reference: Q6I7C2-1

22859161201226286tt124
type: Position
type: ExactPosition
position: 124
reference: Q6I7C2-1

SIP77B50591A2758899
type: Motif Annotation
comment: Nuclear localization signal 2 (NLS2)
range: 22859161201226286tt166tt228

22859161201226286tt166
type: Position
type: ExactPosition
position: 166
reference: Q6I7C2-1

22859161201226286tt228
type: Position
type: ExactPosition
position: 228
reference: Q6I7C2-1

22859161201226286tt41
type: Position
type: ExactPosition
position: 41
reference: Q6I7C2-1

22859161201226286tt65
type: Position
type: ExactPosition
position: 65
reference: Q6I7C2-1

22859161201226286tt93
type: Position
type: ExactPosition
position: 93
reference: Q6I7C2-1

22859161201226286tt104
type: Position
type: ExactPosition
position: 104
reference: Q6I7C2-1

22859161201226286tt105
type: Position
type: ExactPosition
position: 105
reference: Q6I7C2-1

1
subclass of: CHEBI_29035

2
subclass of: CHEBI_29035

Q6I7C2-1
type: Simple Sequence
modified: 2004-07-19
version: 1
mass: 81881
name: PA
value: MSKTFAEIAEAFLEPEAVRIAKEAVEEYGDHERKIIQIGIHFQVCCMFCDEYLSTNGSDRFVLIEGRKRGTAVSLQNELCKSYDLEPLPFLCDIFDREEKQFVEIGITRKADDSYFQSKFGKLGNSCKIFVFSYDGRLDKNCEGPMEEQKLRIFSFLATAADFLRKENMFNEIFLPDNEETIIEMKKGKTFLKLRDESVPLPFQTYEQMKDYCEKFKGNPRELASKVSQMQSNIKLPIKHYEQNKFRQIRLPKGPMAPYTHKFLMEEAWMFTKISDPERSRAGEILIDFFKKGNLSAIRPKDKPLQGKYPIHYKNLWNQIKAAIADRTMVINENDHSEFLGGIGRASKKIPEVSLTQDVITTEGLKQSENKLPEPRSFPKWFNAEWMWAIKDSDLTGWVPMAEYPPADNELEDYAEHLNKTMEGVLQGTNCAREMGKCILTVGALMTECRLFPGKIKVVPIYARSKERKSMQEGLPVPSEMDCLFGICVKSKSHLNKDDGMYTIITFEFSIREPNLEKHQKYTVFEAGHTTVRMKKGESVIGREVPLYLYCRTTALSKIKNDWLSKARRCFITTMDTVETICLRESAKAEENLVEKTLNEKQMWIGKKNGELIAQPLREALRVQLVQQFYFCIYNDSQLEGFCNEQKKILMALEGDKKNKSSFGFNPEGLLEKIEECLINNPMCLFMAQRLNELVIEASKRGAKFFKID

Q6I7C2-2
type: Unknown Sequence
name: PA-X

http://purl.uniprot.org/uniprot/Q6I7C2#attribution-5CB781D2E7C9D9FA758C491BC5E63832
manual: true
evidence: ECO_0000255
source: MF_04063

P68762
type: Protein
reviewed: true
created: 1988-08-01
modified: 2022-12-14
version: 88
mnemonic: HEMA_INCAA
replaces: P07969
replaces: Q6I7C1
citation: http://purl.uniprot.org/citations/15218173
citation: http://purl.uniprot.org/citations/3855244
conflicting sequence: SIP0ACA63BDD676E0C3
recommended name: SIP68A8BDB6EC87F8D1
enzyme: http://purl.uniprot.org/enzyme/3.1.1.53
component: SIP93DE9BB98F676856
component: SIPBEEA49DA515F526C
organism: http://purl.uniprot.org/taxonomy/11553
annotation: SIPDD9DABB7A031D206
annotation: SIP27B2EA7F35A7580C
annotation: SIP86AA4391235C1D0A
annotation: SIPF049CDDBF3B70A38
annotation: SIPEAA03C05DED8250E
annotation: SIP1ECB01942CBB1809
annotation: SIPCD4487F42EE408B1
annotation: SIPF4A11D3F5F8368CD
annotation: PRO_0000440551
annotation: PRO_0000039142
annotation: PRO_0000039143
annotation: SIP636EA2C4A0873A59
annotation: SIP72FC1203E3E7E21F
annotation: SIP620E788B8B5315C9
annotation: SIPF340D58EECCEAD79
annotation: SIP64356AAAF5A7E84D
annotation: SIP7857D84E07FC7D81
annotation: SIP0DE290121421354A
annotation: SIP0820FEA4FC1933EF
annotation: SIP517A8EEB4FDD764F
annotation: SIP834A2872BB88F952
annotation: SIPA02B5D0B285818ED
annotation: SIPC5038517584F741A
annotation: SIP66C94F5BB71EDEE1
annotation: SIP6AF869B83F2CEBF8
annotation: SIP41565E6B77465B3D
annotation: SIPBE606135720C9970
annotation: SIP87E9D07B55C39D8D
annotation: SIP5B1C11BEDCAA23D2
annotation: SIP67940D971F4CA8F5
annotation: SIPE2BACC17E265EDC2
annotation: SIP41AEFAC5585644A3
annotation: SIP60EFB3C4B752AFB0
annotation: SIP520B6F9C7F007257
annotation: SIP52F85EA1E3931094
annotation: SIP32F9429B949EFCB5
annotation: SIP8155D5CF4C19BDAF
annotation: SIPA0B6B23493D5B56F
annotation: SIPF235067E079412F0
annotation: SIP8C0A79A4AEBFD7B5
annotation: SIPDC1F340BD59FD3EE
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/1015
classified with: http://purl.uniprot.org/keywords/1170
classified with: http://purl.uniprot.org/keywords/325
classified with: http://purl.uniprot.org/keywords/348
classified with: http://purl.uniprot.org/keywords/1032
classified with: http://purl.uniprot.org/keywords/378
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/732
classified with: http://purl.uniprot.org/keywords/1133
classified with: http://purl.uniprot.org/keywords/1161
classified with: http://purl.uniprot.org/keywords/261
classified with: http://purl.uniprot.org/keywords/1164
classified with: GO_0020002
classified with: GO_0016020
classified with: GO_0019031
classified with: GO_0055036
classified with: GO_0046789
classified with: GO_0106331
classified with: GO_0106330
classified with: GO_0075509
classified with: GO_0039654
classified with: GO_0019064

P68762-citation-15218173
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC RNA]

http://purl.uniprot.org/citations/3855244
type: Journal Citation
title: Noncumulative sequence changes in the hemagglutinin genes of influenza C virus isolates.
author: Buonagurio D.A.
author: Nakada S.
author: Desselberger U.
author: Krystal M.
author: Palese P.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/3855244
date: 1985
name: Virology
volume: 146
pages: 221-232

P68762-citation-3855244
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 14-655

MF_04072
type: Resource
database: HAMAP
comment: INFV_HEMA
signature sequence match: HAMAP MF 04072 match 1

IPR008980
type: Resource
database: InterPro
comment: Capsid_hemagglutn

IPR007142
type: Resource
database: InterPro
comment: Hemagglutn-estrase_core

IPR003860
type: Resource
database: InterPro
comment: Hemagglutn-estrase_hemagglutn

IPR001364
type: Resource
database: InterPro
comment: Hemagglutn_influenz_A/B

IPR014831
type: Resource
database: InterPro
comment: Hemagglutn_stalk_influenz-C

PF03996
type: Resource
database: Pfam
comment: Hema_esterase
signature sequence match: Pfam PF03996 match 1

PF02710
type: Resource
database: Pfam
comment: Hema_HEFG
signature sequence match: Pfam PF02710 match 1

PF08720
type: Resource
database: Pfam
comment: Hema_stalk
signature sequence match: Pfam PF08720 match 1

SSF49818
type: Resource
database: SUPFAM
comment: Viral protein domain
signature sequence match: SUPFAM SSF49818 match 1

SIP68A8BDB6EC87F8D1
type: Structured Name
full name: Hemagglutinin-esterase-fusion glycoprotein
short name: HEF
ec name: 3.1.1.53

SIP26E9B71572CB16B9
type: Structured Name
full name: Hemagglutinin-esterase-fusion glycoprotein chain 1
short name: HEF1

SIPD5504359DC4177E9
type: Structured Name
full name: Hemagglutinin-esterase-fusion glycoprotein chain 2
short name: HEF2

HE
type: Gene

SIPDD9DABB7A031D206
type: Function Annotation
comment: Binds to the N-acetyl-9-O-acetylneuraminic acid residues on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HEF2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. Displays a receptor-destroying activity which is a neuraminidate-O-acetyl esterase. This activity cleaves off any receptor on the cell surface, which would otherwise prevent virions release. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.

SIPF049CDDBF3B70A38
type: Subunit Annotation
comment: Homotrimer of disulfide-linked HEF1-HEF2.

SIP1ECB01942CBB1809
type: PTM Annotation
comment: In natural infection, inactive HEF is matured into HEF1 and HEF2 outside the cell by one or more trypsin-like, arginine-specific endoprotease.

SIPCD4487F42EE408B1
type: Similarity Annotation
comment: Belongs to the influenza viruses hemagglutinin family.

22577613209219630tt1
type: Position
type: ExactPosition
position: 1
reference: P68762-1

22577613209219630tt14
type: Position
type: ExactPosition
position: 14
reference: P68762-1

PRO_0000440551
type: Chain Annotation
comment: Hemagglutinin-esterase-fusion glycoprotein
mass: 70388
range: 22577613209219630tt15tt655

22577613209219630tt15
type: Position
type: ExactPosition
position: 15
reference: P68762-1

22577613209219630tt655
type: Position
type: ExactPosition
position: 655
reference: P68762-1

PRO_0000039142
type: Chain Annotation
comment: Hemagglutinin-esterase-fusion glycoprotein chain 1
mass: 48039
range: 22577613209219630tt15tt446

22577613209219630tt446
type: Position
type: ExactPosition
position: 446
reference: P68762-1

PRO_0000039143
type: Chain Annotation
comment: Hemagglutinin-esterase-fusion glycoprotein chain 2
mass: 22368
range: 22577613209219630tt447tt655

22577613209219630tt447
type: Position
type: ExactPosition
position: 447
reference: P68762-1

SIP636EA2C4A0873A59
type: Topological Domain Annotation
comment: Extracellular
range: 22577613209219630tt15tt630

22577613209219630tt630
type: Position
type: ExactPosition
position: 630
reference: P68762-1

SIP72FC1203E3E7E21F
type: Transmembrane Annotation
comment: Helical
range: 22577613209219630tt631tt651

22577613209219630tt631
type: Position
type: ExactPosition
position: 631
reference: P68762-1

22577613209219630tt651
type: Position
type: ExactPosition
position: 651
reference: P68762-1

SIP620E788B8B5315C9
type: Topological Domain Annotation
comment: Cytoplasmic
range: 22577613209219630tt652tt655

22577613209219630tt652
type: Position
type: ExactPosition
position: 652
reference: P68762-1

SIPF340D58EECCEAD79
type: Region Annotation
comment: Fusion domain-1
range: 22577613209219630tt15tt40

22577613209219630tt40
type: Position
type: ExactPosition
position: 40
reference: P68762-1

SIP64356AAAF5A7E84D
type: Region Annotation
comment: Esterase domain-1
range: 22577613209219630tt41tt158

22577613209219630tt41
type: Position
type: ExactPosition
position: 41
reference: P68762-1

22577613209219630tt158
type: Position
type: ExactPosition
position: 158
reference: P68762-1

SIP7857D84E07FC7D81
type: Region Annotation
comment: N-acetyl-9-O-acetylneuraminic acid binding
range: 22577613209219630tt158tt310

22577613209219630tt310
type: Position
type: ExactPosition
position: 310
reference: P68762-1

SIP0DE290121421354A
type: Region Annotation
comment: Esterase domain-2
range: 22577613209219630tt310tt364

22577613209219630tt364
type: Position
type: ExactPosition
position: 364
reference: P68762-1

SIP0820FEA4FC1933EF
type: Region Annotation
comment: Fusion domain-2
range: 22577613209219630tt365tt650

22577613209219630tt365
type: Position
type: ExactPosition
position: 365
reference: P68762-1

22577613209219630tt650
type: Position
type: ExactPosition
position: 650
reference: P68762-1

SIP517A8EEB4FDD764F
type: Active Site Annotation
comment: Nucleophile
range: 22577613209219630tt71tt71

22577613209219630tt71
type: Position
type: ExactPosition
position: 71
reference: P68762-1

SIP834A2872BB88F952
type: Active Site Annotation
comment: Charge relay system
range: 22577613209219630tt366tt366

22577613209219630tt366
type: Position
type: ExactPosition
position: 366
reference: P68762-1

SIPA02B5D0B285818ED
type: Active Site Annotation
comment: Charge relay system
range: 22577613209219630tt369tt369

22577613209219630tt369
type: Position
type: ExactPosition
position: 369
reference: P68762-1

SIPC5038517584F741A
type: Glycosylation Annotation
comment: N-linked (GlcNAc...) asparagine; by host
range: 22577613209219630tt26tt26

22577613209219630tt26
type: Position
type: ExactPosition
position: 26
reference: P68762-1

SIP66C94F5BB71EDEE1
type: Glycosylation Annotation
comment: N-linked (GlcNAc...) asparagine; by host
range: 22577613209219630tt61tt61

22577613209219630tt61
type: Position
type: ExactPosition
position: 61
reference: P68762-1

SIP6AF869B83F2CEBF8
type: Glycosylation Annotation
comment: N-linked (GlcNAc...) asparagine; by host
range: 22577613209219630tt144tt144

22577613209219630tt144
type: Position
type: ExactPosition
position: 144
reference: P68762-1

SIP41565E6B77465B3D
type: Glycosylation Annotation
comment: N-linked (GlcNAc...) asparagine; by host
range: 22577613209219630tt189tt189

22577613209219630tt189
type: Position
type: ExactPosition
position: 189
reference: P68762-1

SIPBE606135720C9970
type: Glycosylation Annotation
comment: N-linked (GlcNAc...) asparagine; by host
range: 22577613209219630tt395tt395

22577613209219630tt395
type: Position
type: ExactPosition
position: 395
reference: P68762-1

SIP87E9D07B55C39D8D
type: Glycosylation Annotation
comment: N-linked (GlcNAc...) asparagine; by host
range: 22577613209219630tt552tt552

22577613209219630tt552
type: Position
type: ExactPosition
position: 552
reference: P68762-1

SIP5B1C11BEDCAA23D2
type: Glycosylation Annotation
comment: N-linked (GlcNAc...) asparagine; by host
range: 22577613209219630tt603tt603

22577613209219630tt603
type: Position
type: ExactPosition
position: 603
reference: P68762-1

SIP67940D971F4CA8F5
type: Disulfide Bond Annotation
comment: Interchain (between HEF1 and HEF2 chains)
range: 22577613209219630tt20tt20
range: 22577613209219630tt583tt583

22577613209219630tt20
type: Position
type: ExactPosition
position: 20
reference: P68762-1

22577613209219630tt583
type: Position
type: ExactPosition
position: 583
reference: P68762-1

22577613209219630tt210
type: Position
type: ExactPosition
position: 210
reference: P68762-1

22577613209219630tt252
type: Position
type: ExactPosition
position: 252
reference: P68762-1

22577613209219630tt229
type: Position
type: ExactPosition
position: 229
reference: P68762-1

22577613209219630tt316
type: Position
type: ExactPosition
position: 316
reference: P68762-1

22577613209219630tt237
type: Position
type: ExactPosition
position: 237
reference: P68762-1

22577613209219630tt289
type: Position
type: ExactPosition
position: 289
reference: P68762-1

SIP520B6F9C7F007257
type: Sequence Conflict Annotation
conflicting sequence: SIP0ACA63BDD676E0C3
substitution: EEI
range: 22577613209219630tt207tt209

22577613209219630tt207
type: Position
type: ExactPosition
position: 207
reference: P68762-1

22577613209219630tt209
type: Position
type: ExactPosition
position: 209
reference: P68762-1

SIP52F85EA1E3931094
type: Sequence Conflict Annotation
conflicting sequence: SIP0ACA63BDD676E0C3
substitution: Y
range: 22577613209219630tt214tt214

22577613209219630tt214
type: Position
type: ExactPosition
position: 214
reference: P68762-1

SIP32F9429B949EFCB5
type: Sequence Conflict Annotation
conflicting sequence: SIP0ACA63BDD676E0C3
substitution: Y
range: 22577613209219630tt263tt263

22577613209219630tt263
type: Position
type: ExactPosition
position: 263
reference: P68762-1

SIP8155D5CF4C19BDAF
type: Sequence Conflict Annotation
conflicting sequence: SIP0ACA63BDD676E0C3
substitution: L
range: 22577613209219630tt324tt324

22577613209219630tt324
type: Position
type: ExactPosition
position: 324
reference: P68762-1

SIPA0B6B23493D5B56F
type: Sequence Conflict Annotation
conflicting sequence: SIP0ACA63BDD676E0C3
substitution: Y
range: 22577613209219630tt346tt346

22577613209219630tt346
type: Position
type: ExactPosition
position: 346
reference: P68762-1

SIPF235067E079412F0
type: Sequence Conflict Annotation
conflicting sequence: SIP0ACA63BDD676E0C3
substitution: F
range: 22577613209219630tt458tt458

22577613209219630tt458
type: Position
type: ExactPosition
position: 458
reference: P68762-1

SIP8C0A79A4AEBFD7B5
type: Sequence Conflict Annotation
conflicting sequence: SIP0ACA63BDD676E0C3
substitution: E
range: 22577613209219630tt477tt477

22577613209219630tt477
type: Position
type: ExactPosition
position: 477
reference: P68762-1

SIPDC1F340BD59FD3EE
type: Sequence Conflict Annotation
conflicting sequence: SIP0ACA63BDD676E0C3
substitution: TP
range: 22577613209219630tt637tt638

22577613209219630tt637
type: Position
type: ExactPosition
position: 637
reference: P68762-1

22577613209219630tt638
type: Position
type: ExactPosition
position: 638
reference: P68762-1

P68762-1
type: Simple Sequence
modified: 2006-12-12
version: 2
precursor: true
mass: 71956
value: MFFSLLLMLGLTEAEKIKICLQKQVNSSFSLHNGFGGNLYATEEKRMFELVKPKAGASVLNQSTWIGFGDSRTDKSNSAFPRSADVSAKTADKFRSLSGGSLMLSMFGPPGKVDYLYQGCGKHKVFYEGVNWSPHAAINCYRKNWTDIKLNFQKNIYELASQSHCMSLVNALDKTIPLQATAGVAKNCNNSFLKNPALYTQEVNPSVEKCGKENLAFFTLPTQFGTYECKLHLVASCYFIYDSKEVYNKRGCDNYFQVIYDSSGKVVGGLDNRVSPYTGNSGDTPTMQCDMLQLKPGRYSVRSSPRFLLMPERSYCFDMKEKGPVTAVQSIWGKGRESDHAVDQACLSTPGCMLIQKQKPYIGEADDHHGDQEMRELLSGLDYEARCISQSGWVNETSPFTEEYLLPPKFGRCPLAAKEESIPKIPDGLLIPTSGTDTTVTKPKSRIFGIDDLIIGLLFVAIVEAGIGGYLLGSRKVSGGGVTKESAEKGFEKIGNDIQILRSSTNIAIEKLNDRISHDEQAIRDLTLEIENARSEALLGELGIIRALLVGNISIGLQESLWELASEITNRAGDLAVEVSPGCWVIDNNICDQSCQNFIFKFNETAPVPTIPPLDTKIDLQSDPFYWGSSLGLAITAAISLAALVISGIAICRTK

http://purl.uniprot.org/uniprot/P68762#attribution-1423C5265A0D001C7CCB8E403462E189
manual: true
evidence: ECO_0000255
source: MF_04072

http://purl.uniprot.org/uniprot/P68762#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

Q6I7B9
type: Protein
reviewed: true
created: 2006-12-12
modified: 2022-12-14
version: 67
mnemonic: MAT_INCAA
replaces: Q6I7B8
citation: http://purl.uniprot.org/citations/15218173
citation: http://purl.uniprot.org/citations/9356355
citation: http://purl.uniprot.org/citations/9847305
citation: http://purl.uniprot.org/citations/11297683
citation: http://purl.uniprot.org/citations/21106743
conflicting sequence: SIPFAF13087D9A869D0
conflicting sequence: SIPD55313DE16E58670
recommended name: SIP4A6A9A48823BCBAF
component: SIPEB127BB7FE512429
component: SIP4EB0CDBAF0DA435B
organism: http://purl.uniprot.org/taxonomy/11553
annotation: SIP7B4EA819EDDB4A80
annotation: SIP931A3B5C6C26B60A
annotation: SIP239BD7F373EA55C1
annotation: SIPCE8FAB6393398FB2
annotation: SIP5D8C57498CE5115E
annotation: SIPA53B77FF82314065
annotation: SIPCC28EB7C813A3FC1
annotation: SIP9763DFD9602BBEA0
annotation: SIP67A0DF542964A425
annotation: SIP8BFD6AFC710ECB8A
annotation: SIP5E330403BDDCFAB7
annotation: SIP246DA934BC460B37
annotation: SIPF707876C88297D57
annotation: PRO_0000408875
annotation: PRO_0000269455
annotation: PRO_0000269903
annotation: SIP53FE6EBE9132C345
annotation: SIPC2148131ED842692
annotation: SIP6A501B252C211F99
annotation: SIPA19B0CB6546C4A66
annotation: SIPFB156E7649264350
annotation: SIP7BB229076A3B66D9
annotation: SIP943F5BFBB2ACA91F
annotation: SIPD5A78584CD8F240E
annotation: SIP1B0EAD61A9575FC9
annotation: SIP36146C0E3B24D61D
annotation: VSP_022111
annotation: SIPA7472BD82243B473
annotation: SIP95E516280CD3E049
annotation: SIPAA88AEB570F7E758
annotation: SIPEBDEEEB3A1944711
annotation: SIP61AC4E103D161D35
annotation: SIP166F79C6284D407B
annotation: SIP638A82CE7B329542
annotation: SIP3B61305136187E46
annotation: SIP7F40A0DF7E0DFCDE
annotation: SIP465AEB12E0EC9C58
annotation: SIPC827A720C7658B8A
annotation: SIP78CA4353ED5BDDBB
annotation: SIPBA9B448E3C93EBB5
annotation: SIPEC8B743EEBAE8212
annotation: SIPB51A5EBE4A5B48F6
annotation: SIP2D3BA23D911889AA
annotation: SIPFB848C1B4C11AFDF
annotation: SIPDF6FA214F9416735
annotation: SIP066E4DE1C58DF205
annotation: SIPB8A3A8EF3CDABECF
existence: Evidence at Protein Level Existence
classified with: http://purl.uniprot.org/keywords/2
classified with: http://purl.uniprot.org/keywords/25
classified with: http://purl.uniprot.org/keywords/1015
classified with: http://purl.uniprot.org/keywords/325
classified with: http://purl.uniprot.org/keywords/1032
classified with: http://purl.uniprot.org/keywords/1038
classified with: http://purl.uniprot.org/keywords/564
classified with: http://purl.uniprot.org/keywords/597
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/735
classified with: http://purl.uniprot.org/keywords/1133
classified with: http://purl.uniprot.org/keywords/1182
classified with: http://purl.uniprot.org/keywords/468
classified with: GO_0044167

Q6I7B9-citation-15218173
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC RNA]

http://purl.uniprot.org/citations/9356355
type: Journal Citation
title: The CM2 protein of influenza C virus is an oligomeric integral membrane glycoprotein structurally analogous to influenza A virus M2 and influenza B virus NB proteins.
author: Pekosz A.
author: Lamb R.A.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/9356355
date: 1997
name: Virology
volume: 237
pages: 439-451

Q6I7B9-citation-9356355
type: Citation Statement
scope: CHARACTERIZATION
scope: SUBCELLULAR LOCATION
scope: GLYCOSYLATION
scope: MUTAGENESIS OF THR-272
scope: TOPOLOGY OF CM2

http://purl.uniprot.org/citations/9847305
type: Journal Citation
title: Influenza C virus CM2 protein is produced from a 374-amino-acid protein (P42) by signal peptidase cleavage.
author: Hongo S.
author: Sugawara K.
author: Muraki Y.
author: Matsuzaki Y.
author: Takashita E.
author: Kitame F.
author: Nakamura K.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/9847305
date: 1999
name: J. Virol.
volume: 73
pages: 46-50

Q6I7B9-citation-9847305
type: Citation Statement
scope: CLEAVAGE BY HOST SIGNAL PEPTIDASE

http://purl.uniprot.org/citations/11297683
type: Journal Citation
title: The sites for fatty acylation, phosphorylation and intermolecular disulphide bond formation of influenza C virus CM2 protein.
author: Li Z.N.
author: Hongo S.
author: Sugawara K.
author: Sugahara K.
author: Tsuchiya E.
author: Matsuzaki Y.
author: Nakamura K.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/11297683
date: 2001
name: J. Gen. Virol.
volume: 82
pages: 1085-1093

Q6I7B9-citation-11297683
type: Citation Statement
scope: SUBUNIT
scope: PALMITOYLATION AT CYS-324
scope: PHOSPHORYLATION AT SER-337 AND SER-362
scope: MUTAGENESIS OF CYS-260; CYS-265; CYS-279; SER-337 AND SER-367

http://purl.uniprot.org/citations/21106743
type: Journal Citation
title: Role of the CM2 protein in the influenza C virus replication cycle.
author: Furukawa T.
author: Muraki Y.
author: Noda T.
author: Takashita E.
author: Sho R.
author: Sugawara K.
author: Matsuzaki Y.
author: Shimotai Y.
author: Hongo S.
primary topic of: https://pubmed.ncbi.nlm.nih.gov/21106743
date: 2011
name: J. Virol.
volume: 85
pages: 1322-1329

Q6I7B9-citation-21106743
type: Citation Statement
scope: FUNCTION

EMBL BAD24942.1
comment: Different termination.

EMBL BAD24943.1
comment: Different initiation.

5M1M
type: Structure Resource
database: PDB
method: X-Ray Crystallography
resolution: 1.50
chain sequence mapping: PDB 5M1M tt1tt155

PDB 5M1M tt1tt155
chain: A=1-155

IPR004271
type: Resource
database: InterPro
comment: CM1

IPR004267
type: Resource
database: InterPro
comment: CM2

PF03026
type: Resource
database: Pfam
comment: CM1
signature sequence match: Pfam PF03026 match 1

PF03021
type: Resource
database: Pfam
comment: CM2
signature sequence match: Pfam PF03021 match 1

SIP4A6A9A48823BCBAF
type: Structured Name
full name: Polyprotein p42

SIPC1F781B50E5A5943
type: Structured Name
full name: Protein M1'

SIPC50239150AA1AD17
type: Structured Name
full name: CM1'

SIP75B5BC7686E8769A
type: Structured Name
full name: p31

SIP8817F788778C49BE
type: Structured Name
full name: Protein CM2

M
type: Gene

SIP7B4EA819EDDB4A80
type: Function Annotation
comment: Ion channel, which might have a role in genome packaging and uncoating processes.

SIP931A3B5C6C26B60A
type: Subunit Annotation
comment: Homodimer; disulfide-linked. Homotetramer; disulfide-linked.

SIPCC28EB7C813A3FC1
type: PTM Annotation
comment: Palmitoylated.

SIP9763DFD9602BBEA0
type: PTM Annotation
comment: N-glycosylated.

SIP67A0DF542964A425
type: PTM Annotation
comment: Ser-337 is the major site of phosphorylation, Ser-362 being a minor one.

SIP8BFD6AFC710ECB8A
type: Annotation
comment: Produced by unspliced mRNA.
sequence: Q6I7B9-1

SIP5E330403BDDCFAB7
type: Similarity Annotation
comment: Belongs to the influenza C protein M1 family.

PRO_0000408875
type: Chain Annotation
comment: Polyprotein p42
mass: 41740
range: 22859161201162542tt1tt374

22859161201162542tt1
type: Position
type: ExactPosition
position: 1
reference: Q6I7B9-1

22859161201162542tt374
type: Position
type: ExactPosition
position: 374
reference: Q6I7B9-1

PRO_0000269455
type: Chain Annotation
comment: Protein M1'
mass: 28803
range: 22859161201162542tt1tt259

22859161201162542tt259
type: Position
type: ExactPosition
position: 259
reference: Q6I7B9-1

PRO_0000269903
type: Chain Annotation
comment: Protein CM2
mass: 12956
range: 22859161201162542tt260tt374

22859161201162542tt260
type: Position
type: ExactPosition
position: 260
reference: Q6I7B9-1

SIP53FE6EBE9132C345
type: Topological Domain Annotation
comment: Cytoplasmic
range: 22859161201162542tt1tt238

22859161201162542tt238
type: Position
type: ExactPosition
position: 238
reference: Q6I7B9-1

SIPC2148131ED842692
type: Transmembrane Annotation
comment: Helical; Signal-anchor for type II membrane protein
range: 22859161201162542tt239tt259

22859161201162542tt239
type: Position
type: ExactPosition
position: 239
reference: Q6I7B9-1

SIP6A501B252C211F99
type: Topological Domain Annotation
comment: Extracellular
range: 22859161201162542tt260tt288

22859161201162542tt288
type: Position
type: ExactPosition
position: 288
reference: Q6I7B9-1

SIPA19B0CB6546C4A66
type: Transmembrane Annotation
comment: Helical
range: 22859161201162542tt289tt309

22859161201162542tt289
type: Position
type: ExactPosition
position: 289
reference: Q6I7B9-1

22859161201162542tt309
type: Position
type: ExactPosition
position: 309
reference: Q6I7B9-1

SIPFB156E7649264350
type: Topological Domain Annotation
comment: Cytoplasmic
range: 22859161201162542tt310tt374

22859161201162542tt310
type: Position
type: ExactPosition
position: 310
reference: Q6I7B9-1

SIP7BB229076A3B66D9
type: Site Annotation
comment: Cleavage; by host signal peptidase
range: 22859161201162542tt259tt260

SIP943F5BFBB2ACA91F
type: Modified Residue Annotation
comment: Phosphoserine; by host
range: 22859161201162542tt337tt337

22859161201162542tt337
type: Position
type: ExactPosition
position: 337
reference: Q6I7B9-1

SIPD5A78584CD8F240E
type: Modified Residue Annotation
comment: Phosphoserine; by host
range: 22859161201162542tt362tt362

22859161201162542tt362
type: Position
type: ExactPosition
position: 362
reference: Q6I7B9-1

SIP1B0EAD61A9575FC9
type: Lipidation Annotation
comment: S-palmitoyl cysteine; by host
range: 22859161201162542tt324tt324

22859161201162542tt324
type: Position
type: ExactPosition
position: 324
reference: Q6I7B9-1

SIP36146C0E3B24D61D
type: Glycosylation Annotation
comment: N-linked (GlcNAc...) asparagine; by host
range: 22859161201162542tt270tt270

22859161201162542tt270
type: Position
type: ExactPosition
position: 270
reference: Q6I7B9-1

VSP_022111
type: Alternative Sequence Annotation
comment: In isoform M1.
range: 22859161201162542tt243tt374

22859161201162542tt243
type: Position
type: ExactPosition
position: 243
reference: Q6I7B9-1

SIPA7472BD82243B473
type: Mutagenesis Annotation
comment: Complete loss of oligomerization; when associated with A-265 and A279.
substitution: A
range: 22859161201162542tt260tt260

SIP95E516280CD3E049
type: Mutagenesis Annotation
comment: Complete loss of oligomerization; when associated with A-260 and A279.
substitution: A
range: 22859161201162542tt265tt265

22859161201162542tt265
type: Position
type: ExactPosition
position: 265
reference: Q6I7B9-1

SIPAA88AEB570F7E758
type: Mutagenesis Annotation
comment: Loss of carbohydrate modification.
substitution: A
range: 22859161201162542tt272tt272

22859161201162542tt272
type: Position
type: ExactPosition
position: 272
reference: Q6I7B9-1

SIPEBDEEEB3A1944711
type: Mutagenesis Annotation
comment: Complete loss of oligomerization; when associated with A-260 and A265.
substitution: A
range: 22859161201162542tt279tt279

22859161201162542tt279
type: Position
type: ExactPosition
position: 279
reference: Q6I7B9-1

SIP61AC4E103D161D35
type: Mutagenesis Annotation
comment: Complete loss of palmitoylation.
substitution: A
range: 22859161201162542tt324tt324

SIP166F79C6284D407B
type: Mutagenesis Annotation
comment: 93% loss of phosphorylation. Complete loss of phosphorylation; when associated with A-362.
substitution: A
range: 22859161201162542tt337tt337

SIP638A82CE7B329542
type: Mutagenesis Annotation
comment: Complete loss of phosphorylation; when associated with A-337.
substitution: A
range: 22859161201162542tt362tt362

SIP3B61305136187E46
type: Mutagenesis Annotation
comment: No effet on phosphorylation.
substitution: A
range: 22859161201162542tt367tt367

22859161201162542tt367
type: Position
type: ExactPosition
position: 367
reference: Q6I7B9-1

22859161201162542tt3
type: Position
type: ExactPosition
position: 3
reference: Q6I7B9-1

22859161201162542tt13
type: Position
type: ExactPosition
position: 13
reference: Q6I7B9-1

22859161201162542tt14
type: Position
type: ExactPosition
position: 14
reference: Q6I7B9-1

22859161201162542tt16
type: Position
type: ExactPosition
position: 16
reference: Q6I7B9-1

22859161201162542tt19
type: Position
type: ExactPosition
position: 19
reference: Q6I7B9-1

22859161201162542tt29
type: Position
type: ExactPosition
position: 29
reference: Q6I7B9-1

22859161201162542tt33
type: Position
type: ExactPosition
position: 33
reference: Q6I7B9-1

22859161201162542tt44
type: Position
type: ExactPosition
position: 44
reference: Q6I7B9-1

22859161201162542tt52
type: Position
type: ExactPosition
position: 52
reference: Q6I7B9-1

22859161201162542tt65
type: Position
type: ExactPosition
position: 65
reference: Q6I7B9-1

22859161201162542tt73
type: Position
type: ExactPosition
position: 73
reference: Q6I7B9-1

22859161201162542tt82
type: Position
type: ExactPosition
position: 82
reference: Q6I7B9-1

22859161201162542tt83
type: Position
type: ExactPosition
position: 83
reference: Q6I7B9-1

22859161201162542tt85
type: Position
type: ExactPosition
position: 85
reference: Q6I7B9-1

22859161201162542tt88
type: Position
type: ExactPosition
position: 88
reference: Q6I7B9-1

22859161201162542tt101
type: Position
type: ExactPosition
position: 101
reference: Q6I7B9-1

22859161201162542tt104
type: Position
type: ExactPosition
position: 104
reference: Q6I7B9-1

22859161201162542tt113
type: Position
type: ExactPosition
position: 113
reference: Q6I7B9-1

22859161201162542tt118
type: Position
type: ExactPosition
position: 118
reference: Q6I7B9-1

22859161201162542tt130
type: Position
type: ExactPosition
position: 130
reference: Q6I7B9-1

22859161201162542tt132
type: Position
type: ExactPosition
position: 132
reference: Q6I7B9-1

22859161201162542tt134
type: Position
type: ExactPosition
position: 134
reference: Q6I7B9-1

22859161201162542tt137
type: Position
type: ExactPosition
position: 137
reference: Q6I7B9-1

22859161201162542tt152
type: Position
type: ExactPosition
position: 152
reference: Q6I7B9-1

Q6I7B9-1
type: Simple Sequence
modified: 2007-01-09
version: 2
mass: 41740
name: p42
value: MAHEILIAETEAFLKNVAPETRTAIISAITGGKSACKSAAKLIKNEHLPLMSGEATTMHIVMRCLYPEIKPWKKASDMLNKATSSLKKSEGRDIRKQMKAAGDFLGVESMMKMRAFRDDQIMEMVEEVYDHPDDYTPDIRIGTITAWLRCKNKKSERYRSNVSESGRTALKIHEVRKASTAMNEIAGITGLGEEALSLQRQTESLAILCNHTFGSNIMRPHLEKAIKGVEGRVGEMGRMAMKWLVVIICFSITSQPASACNLKTCLKLFNNTDAVTVHCFNENQGYMLTLASLGLGIITMLYLLVKIIIELVNGFVLGRWERWCGDIKTTIMPEIDSMEKDIALSRERLDLGEDAPDETDNSPIPFSNDGIFEI

Q6I7B9-2
type: Modified Sequence
name: M1
name: CM1
based on: Q6I7B9-1
value: MAHEILIAETEAFLKNVAPETRTAIISAITGGKSACKSAAKLIKNEHLPLMSGEATTMHIVMRCLYPEIKPWKKASDMLNKATSSLKKSEGRDIRKQMKAAGDFLGVESMMKMRAFRDDQIMEMVEEVYDHPDDYTPDIRIGTITAWLRCKNKKSERYRSNVSESGRTALKIHEVRKASTAMNEIAGITGLGEEALSLQRQTESLAILCNHTFGSNIMRPHLEKAIKGVEGRVGEMGRMAMK
modification: VSP_022111

http://purl.uniprot.org/uniprot/Q6I7B9#attribution-DC036A124EC8E88DF072B29F6D9BB9FE
manual: true
evidence: ECO_0000255

http://purl.uniprot.org/uniprot/Q6I7B9#attribution-4FF8DCE3143B8425DE5F662F5079F149
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/11297683

http://purl.uniprot.org/uniprot/Q6I7B9#attribution-A29AC1BB0456B73A7C6C21D9190EF26F
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/21106743

http://purl.uniprot.org/uniprot/Q6I7B9#attribution-1AAA06136437649593ACC2241187FD48
manual: true
evidence: ECO_0000269
source: http://purl.uniprot.org/citations/9356355

http://purl.uniprot.org/uniprot/Q6I7B9#attribution-080ED3982FEC43F7C43A0689717F3D20
manual: true
evidence: ECO_0000305

http://purl.uniprot.org/uniprot/Q6I7B9#attribution-A33ED2C34C6D692BC00FB16985A7CD58
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/11297683

http://purl.uniprot.org/uniprot/Q6I7B9#attribution-23E25E78268FEBC27AB44803DACA14AD
manual: true
evidence: ECO_0000305
source: http://purl.uniprot.org/citations/9356355

Q6I7C3
type: Protein
reviewed: true
created: 2006-12-12
modified: 2022-12-14
version: 61
mnemonic: RDRP_INCAA
citation: http://purl.uniprot.org/citations/15218173
recommended name: SIPD5680B46796F8414
alternative name: SIP3C6F212153292E21
alternative name: SIPBFDB12D124451FC4
enzyme: http://purl.uniprot.org/enzyme/2.7.7.48
organism: http://purl.uniprot.org/taxonomy/11553
annotation: SIP5825FC248DE9F5DF
annotation: SIP487088B456C4A4DA
annotation: SIP2884D2209501776C
annotation: SIP496251872C2A5994
annotation: SIPC6B993FF4605A1B8
annotation: SIP2D00F80148FEEA27
annotation: PRO_0000269452
annotation: SIP971409431A35D316
annotation: SIP70D1811F3D5AB92A
annotation: SIP4F1125A4770827A8
annotation: SIPCABC18E8E386107A
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/1035
classified with: http://purl.uniprot.org/keywords/1048
classified with: http://purl.uniprot.org/keywords/1104
classified with: http://purl.uniprot.org/keywords/547
classified with: http://purl.uniprot.org/keywords/597
classified with: http://purl.uniprot.org/keywords/1185
classified with: http://purl.uniprot.org/keywords/696
classified with: http://purl.uniprot.org/keywords/693
classified with: http://purl.uniprot.org/keywords/1195
classified with: GO_0030430
classified with: GO_0042025
classified with: GO_0000166
classified with: GO_0003723
classified with: GO_0003968
classified with: GO_0006351
classified with: GO_0039523
classified with: GO_0039694
classified with: GO_0019083
sequence: Q6I7C3-1
proteome: Genome

Q6I7C3-citation-15218173
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE [GENOMIC RNA]

MF_04065
type: Resource
database: HAMAP
comment: INFV_RDRP
signature sequence match: HAMAP MF 04065 match 1

IPR007099
type: Resource
database: InterPro
comment: RNA-dir_pol_NSvirus

IPR001407
type: Resource
database: InterPro
comment: RNA_pol_PB1_influenza

PF00602
type: Resource
database: Pfam
comment: Flu_PB1
signature sequence match: Pfam PF00602 match 1

PIRSF000827
type: Resource
database: PIRSF
comment: RdRPol_OMV
signature sequence match: PIRSF PIRSF000827 match 1

PS50525
type: Resource
database: PROSITE
comment: RDRP_SSRNA_NEG_SEG
signature sequence match: PROSITE PS50525 match 1

SIPD5680B46796F8414
type: Structured Name
full name: RNA-directed RNA polymerase catalytic subunit
ec name: 2.7.7.48

SIP3C6F212153292E21
type: Structured Name
full name: Polymerase basic protein 1
short name: PB1

SIPBFDB12D124451FC4
type: Structured Name
full name: RNA-directed RNA polymerase subunit P1

PB1
type: Gene

SIP5825FC248DE9F5DF
type: Function Annotation
comment: RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments. The transcription of viral mRNAs occurs by a unique mechanism called cap-snatching. 5' methylated caps of cellular mRNAs are cleaved after 10-13 nucleotides by PA. In turn, these short capped RNAs are used as primers by PB1 for transcription of viral mRNAs. During virus replication, PB1 initiates RNA synthesis and copy vRNA into complementary RNA (cRNA) which in turn serves as a template for the production of more vRNAs.

SIP2884D2209501776C
type: Subunit Annotation
comment: Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA. Interacts (via N-terminus) with PA (via C-terminus). Interacts (via C-terminus) with PB2 (via N-terminus); this interaction is essential for transcription initiation.

SIPC6B993FF4605A1B8
type: PTM Annotation
comment: Phosphorylated by host PRKCA.

SIP2D00F80148FEEA27
type: Similarity Annotation
comment: Belongs to the influenza viruses polymerase PB1 family.

PRO_0000269452
type: Chain Annotation
comment: RNA-directed RNA polymerase catalytic subunit
mass: 86071
range: 22859161201226542tt1tt754

22859161201226542tt1
type: Position
type: ExactPosition
position: 1
reference: Q6I7C3-1

22859161201226542tt754
type: Position
type: ExactPosition
position: 754
reference: Q6I7C3-1

SIP971409431A35D316
type: Domain Extent Annotation
comment: RdRp catalytic
range: 22859161201226542tt288tt484

22859161201226542tt288
type: Position
type: ExactPosition
position: 288
reference: Q6I7C3-1

22859161201226542tt484
type: Position
type: ExactPosition
position: 484
reference: Q6I7C3-1

SIP70D1811F3D5AB92A
type: Region Annotation
comment: Promoter-binding site
range: 22859161201226542tt251tt258

22859161201226542tt251
type: Position
type: ExactPosition
position: 251
reference: Q6I7C3-1

22859161201226542tt258
type: Position
type: ExactPosition
position: 258
reference: Q6I7C3-1

SIP4F1125A4770827A8
type: Motif Annotation
comment: Nuclear localization signal
range: 22859161201226542tt189tt197

22859161201226542tt189
type: Position
type: ExactPosition
position: 189
reference: Q6I7C3-1

22859161201226542tt197
type: Position
type: ExactPosition
position: 197
reference: Q6I7C3-1

SIPCABC18E8E386107A
type: Motif Annotation
comment: Nuclear localization signal
range: 22859161201226542tt205tt218

22859161201226542tt205
type: Position
type: ExactPosition
position: 205
reference: Q6I7C3-1

22859161201226542tt218
type: Position
type: ExactPosition
position: 218
reference: Q6I7C3-1

Q6I7C3-1
type: Simple Sequence
modified: 2004-07-19
version: 1
mass: 86071
value: MEINPYLMFLNNDVTSLISTTYPYTGPPPMSHGSSTKYTLETIKRTYDYSRTSVEKTSKVFNIPRRKFCNCLEDKDELVKPTGNVDISSLLGLAEMMEKRMGEGFFKHCVMEAETEILKMHFSRLTEGRQTYDWTSERNMPAATALQLTVDAIKETEGPFKGTTMLEYCNKMIEMLDWKEVKFRKVKTMVRREKDKRSGKEIKTKVPVMGIDSIKHDEFLIRALTINTMAKDGERGKLQRRAIATPGMIVRPFSKIVETVAQKICEKLKESGLPVGGNEKKAKLKTTVTSLNARMNSDQFAVNITGDNSKWNECQQPEAYLALLAYITKDSSDLMKDLCSVAPVLFCNKFVKLGQGIRLSNKRKTKEVIIKAEKMGKYKNLMREEYKNLFEPLEKYIQKDVCFLPGGMLMGMFNMLSTVLGVSTLCYMDEELKAKGCFWTGLQSSDDFVLFAVASNWSNIHWTIRRFNAVCKLIGINMSLEKSYGSLPELFEFTSMFFDGEFVSNLAMELPAFTTAGVNEGVDFTAAMSIIKTNMINNSLSPSTALMALRICLQEFRATYRVHPWDSRVKGGRMKIINEFIKTIENKDGLLIADGGKLMNNISTLHIPEEVLKFEKMDEQYRNRVFNPKNPFTNFDKTIDIFRAHGPIRVEENEAVVSTHSFRTRANRTLLNTDMRAMMAEEKRYQMVCDMFKSVFESADINPPIGAMSIGEAIEEKLLERAKMKRDIGAIEDSEYEEIKDIIRDAKKARIESR

http://purl.uniprot.org/uniprot/Q6I7C3#attribution-FEFBBCBD8AB36A3C5226BC7162AEF468
manual: true
evidence: ECO_0000255
source: MF_04065

Q84084
type: Protein
reviewed: false
created: 1996-11-01
modified: 2022-12-14
version: 39
mnemonic: Q84084_INCAA
citation: http://purl.uniprot.org/citations/2943076
recommended name: SIP4D32EB77EC3C1EF2
alternative name: SIP3C68454273B7F08D
organism: http://purl.uniprot.org/taxonomy/11553
annotation: SIP484659161DF2FB18
annotation: SIPBCD1F3F6F62EA21C
annotation: SIP25FEA24E7A9C41A1
annotation: SIPAD9DE3CDBCBFED74
annotation: SIPAFF6A7175EC1ECD9
existence: Predicted Existence
classified with: GO_0005737
classified with: GO_0030430
sequence: Q84084-1

Q84084-citation-2943076
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

C/Ann Arbor/1/50
type: Strain

SIP4D32EB77EC3C1EF2
type: Structured Name
full name: Non-structural protein 1

SIP3C68454273B7F08D
type: Structured Name
full name: NS1C

SIP484659161DF2FB18
type: Function Annotation
comment: Suppresses the RNA silencing-based antiviral response in Drosophila cells.

SIP25FEA24E7A9C41A1
type: Domain Extent Annotation
comment: Flu_C_NS2
range: 22861269912007726tt1tt57

22861269912007726tt1
type: Position
type: ExactPosition
position: 1
reference: Q84084-1

22861269912007726tt57
type: Position
type: ExactPosition
position: 57
reference: Q84084-1

SIPAD9DE3CDBCBFED74
type: Domain Extent Annotation
comment: Flu_C_NS1
range: 22861269912007726tt58tt219

22861269912007726tt58
type: Position
type: ExactPosition
position: 58
reference: Q84084-1

22861269912007726tt219
type: Position
type: ExactPosition
position: 219
reference: Q84084-1

Q84084-1
type: Simple Sequence
modified: 1996-11-01
version: 1
fragment: single
mass: 31865
value: VKSTNLMAFVATKMLERQEDLDTCTEMQVEKMKTSTKARLRTESSFAPRTWEDAIKDGELLFNGTILQAESPTMTPVSVEMKGKKLPIDFAPSNIAPIGQNPIYLSPCIPNFDGNVWEATMYHHRGATLTKTMNCNCFQRTIWCHPNPSRMRLSYAFVLYCRNTKKICGCLIARQVAGIETGIRKCFRCIKSGFVMATDEISLTILRSIKSGAQLDPYWEMKHQILTRLKLICSRLEKLDHNLSKAVLGIQNSEDLILIIHNRDVCKNIILMIKSLCNSLI

A0A348BRC8
type: Protein
reviewed: false
created: 2018-11-07
modified: 2022-12-14
version: 17
mnemonic: A0A348BRC8_INCAA
citation: SIPBEC62587904C82C4
recommended name: SIPF98F15841C7FD795
enzyme: http://purl.uniprot.org/enzyme/3.1.1.53
organism: http://purl.uniprot.org/taxonomy/11553
annotation: SIPA054449C6721D43F
annotation: SIP09A5650881CF0483
annotation: SIP08EE3746F7B96902
annotation: SIPAFDCEC323F732219
annotation: SIPFDCCE1D8F0E38EFE
annotation: SIPF05AABE96E55E153
annotation: SIP0C9F22C267EEE4C9
annotation: SIPE80ECE944A7B72FE
annotation: SIPBD37FCA6ACFF8CDF
annotation: SIP92D343DE75101359
annotation: SIP23F2F4C62E30178E
annotation: SIPE439AC3B3C6E1D85
annotation: SIP468AA7910040EEAD
existence: Inferred from Homology Existence
classified with: http://purl.uniprot.org/keywords/175
classified with: http://purl.uniprot.org/keywords/1015
classified with: http://purl.uniprot.org/keywords/1170
classified with: http://purl.uniprot.org/keywords/325
classified with: http://purl.uniprot.org/keywords/348
classified with: http://purl.uniprot.org/keywords/1032
classified with: http://purl.uniprot.org/keywords/378
classified with: http://purl.uniprot.org/keywords/1133
classified with: http://purl.uniprot.org/keywords/1161
classified with: http://purl.uniprot.org/keywords/261
classified with: GO_0020002
classified with: GO_0005886
classified with: GO_0019031
classified with: GO_0055036
classified with: GO_0046789
classified with: GO_0106331
classified with: GO_0106330
classified with: GO_0039654
classified with: GO_0019064
classified with: GO_0046718
classified with: GO_0019062
sequence: A0A348BRC8-1

SIPBEC62587904C82C4
type: Journal Citation
title: Neutralizing Epitopes and Residues Mediating the Potential Antigenic Drift of the Hemagglutinin-Esterase Protein of Influenza C Virus.
author: Matsuzaki Y.
author: Sugawara K.
author: Furuse Y.
author: Shimotai Y.
author: Hongo S.
author: Mizuta K.
author: Nishimura H.
date: 2018
name: Viruses
volume: 10
pages: 417

…
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

C/Ann Arbor/1/50
type: Strain

SIPF98F15841C7FD795
type: Structured Name
full name: Hemagglutinin-esterase-fusion glycoprotein
ec name: 3.1.1.53

HE
type: Gene

SIPA054449C6721D43F
type: Function Annotation
comment: Binds to the N-acetyl-9-O-acetylneuraminic acid residues on the cell surface, bringing about the attachment of the virus particle to the cell. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induce an irreversible conformational change in HEF2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. Displays a receptor-destroying activity which is a neuraminidate-O-acetyl esterase. This activity cleaves off any receptor on the cell surface, which would otherwise prevent virions release. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell.

SIPAFDCEC323F732219
type: Subunit Annotation
comment: Homotrimer of disulfide-linked HEF1-HEF2.

SIPF05AABE96E55E153
type: PTM Annotation
comment: In natural infection, inactive HEF is matured into HEF1 and HEF2 outside the cell by one or more trypsin-like, arginine-specific endoprotease.

SIP0C9F22C267EEE4C9
type: Similarity Annotation
comment: Belongs to the influenza type C/coronaviruses hemagglutinin-esterase family.

SIPE80ECE944A7B72FE
type: Transmembrane Annotation
comment: Helical
range: -9218573457629585362tt619tt646

-9218573457629585362tt619
type: Position
type: ExactPosition
position: 619
reference: A0A348BRC8-1

-9218573457629585362tt646
type: Position
type: ExactPosition
position: 646
reference: A0A348BRC8-1

SIPBD37FCA6ACFF8CDF
type: Domain Extent Annotation
comment: Hema_esterase
range: -9218573457629585362tt33tt413

-9218573457629585362tt33
type: Position
type: ExactPosition
position: 33
reference: A0A348BRC8-1

-9218573457629585362tt413
type: Position
type: ExactPosition
position: 413
reference: A0A348BRC8-1

SIP92D343DE75101359
type: Domain Extent Annotation
comment: Hema_HEFG
range: -9218573457629585362tt145tt298

-9218573457629585362tt145
type: Position
type: ExactPosition
position: 145
reference: A0A348BRC8-1

-9218573457629585362tt298
type: Position
type: ExactPosition
position: 298
reference: A0A348BRC8-1

SIP23F2F4C62E30178E
type: Domain Extent Annotation
comment: Hema_stalk
range: -9218573457629585362tt441tt615

-9218573457629585362tt441
type: Position
type: ExactPosition
position: 441
reference: A0A348BRC8-1

-9218573457629585362tt615
type: Position
type: ExactPosition
position: 615
reference: A0A348BRC8-1

-9218573457629585362tt503
type: Position
type: ExactPosition
position: 503
reference: A0A348BRC8-1

-9218573457629585362tt530
type: Position
type: ExactPosition
position: 530
reference: A0A348BRC8-1

-9218573457629585362tt1
type: Position
type: ExactPosition
position: 1
reference: A0A348BRC8-1

A0A348BRC8-1
type: Simple Sequence
modified: 2018-11-07
version: 1
fragment: single
mass: 71387
value: LMLGLTEAEKIKICLQKQVNSSFSLHNGFGGNLYATEEKRMFELVKPKAGASVLNQSTWIGFGDSRTDKSNSAFPRSADVSAKTADKFRSLSGGSLMLSMFGPPGKVDYLYQGCGKHKVFYEGVNWSPHAAINCYRKNWTDIKLNFQKNIYELASQSHCMSLVNALDKTIPLQATAGVAKNCNNSFLKNPALYTQEVNPSEEKCGKENLAFFTLPTQFGTYECKLHLVASCYFIYDSKEVYNKRGCDNYFQVIYDSYGKVVGGLDNRVSPYTGNSGDTPTMQCDMLQLKPGRYSVRSSPRFLLMPERSYCFDMKEKGPVTAVQSIWGKGRESDHAVDQACLSTPGCMLIQKQKPYIGEADDHHGDQEMRELLSGLDYEARCISQSGWVNETSPFTEEYLLPPKFGRCPLAAKEESIPKIPDGLLIPTSGTDTTVTKPKSRIFGIDDLIIGLFFVAIVEAGIGGYLLGSRKESGGGVTKESAEKGFEKIGNDIQILRSSTNIAIEKLNDRISHDEQAIRDLTLEIENARSEALLGELGIIRALLVGNISIGLQESLWELASEITNRAGDLAVEVSPGCWVIDNNICDQSCQNFIFKFNETAPVPTIPPLDTKIDLQSDPFYWGSSLGLAITAAISLAALVISGIAICRTK

Q84083
type: Protein
reviewed: false
created: 1996-11-01
modified: 2020-12-02
version: 37
mnemonic: Q84083_INCAA
citation: http://purl.uniprot.org/citations/2943076
submitted name: SIP2E31182E1D1A22A9
organism: http://purl.uniprot.org/taxonomy/11553
annotation: SIP29F85439C1971673
annotation: SIPD26A9C37E80F0F41
existence: Predicted Existence
sequence: VKSTNLMAFVATKMLERQEDLDTCTEMQVEKMKTSTKARLRTESSFAPRTWEDAIKDEILRRSVDASSLDRWPELKQELENVSDALKADSLWLPMKSLSLYSEVSNQELSSIPIGK

Q84083-citation-2943076
type: Citation Statement
scope: NUCLEOTIDE SEQUENCE

C/Ann Arbor/1/50
type: Strain

SIP2E31182E1D1A22A9
type: Structured Name
full name: Nonstructural protein 2

SIP29F85439C1971673
type: Domain Extent Annotation
comment: Flu_C_NS2
range: 22861269912007470tt1tt57

22861269912007470tt1
type: Position
type: ExactPosition
position: 1
reference: VKSTNLMAFVATKMLERQEDLDTCTEMQVEKMKTSTKARLRTESSFAPRTWEDAIKDEILRRSVDASSLDRWPELKQELENVSDALKADSLWLPMKSLSLYSEVSNQELSSIPIGK

22861269912007470tt57
type: Position
type: ExactPosition
position: 57
reference: VKSTNLMAFVATKMLERQEDLDTCTEMQVEKMKTSTKARLRTESSFAPRTWEDAIKDEILRRSVDASSLDRWPELKQELENVSDALKADSLWLPMKSLSLYSEVSNQELSSIPIGK

VKSTNLMAFVATKMLERQEDLDTCTEMQVEKMKTSTKARLRTESSFAPRTWEDAIKDEILRRSVDASSLDRWPELKQELENVSDALKADSLWLPMKSLSLYSEVSNQELSSIPIGK
type: Simple Sequence
modified: 1996-11-01
version: 1
fragment: single
mass: 13254