YbaK/aminoacyl-tRNA synthetase-associated
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Endoribonuclease L-PSP/chorismate mutase-like
Major facilitator superfamily (MFS) profile
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
Transposase IS116/IS110/IS902 C-terminal
RNA binding; important for wobble base 34 recognition
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Schiff-base intermediate with substrate; via pyruvic acid
Interaction with polymerase core subunit RpoC
Activator of Hsp90 ATPase homologue 1-like C-terminal
Flagellar basal body rod protein N-terminal
Resolvase/invertase-type recombinase catalytic
Glycosyl-hydrolase 97 C-terminal oligomerisation
TonB-dependent receptor-like beta-barrel
Alginate export domain-containing protein
Alpha galactosidase C-terminal beta sandwich
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Glycosyl transferase family 3 N-terminal
RNA polymerase sigma factor 70 region 4 type 2
SUF system FeS cluster assembly SufBD N-terminal
Prokaryotic-type class I peptide chain release factors
Mandelate racemase/muconate lactonizing enzyme C-terminal
Penicillin-binding protein transpeptidase
RND efflux pump membrane fusion protein barrel-sandwich
Calcineurin-like phosphoesterase domain-containing protein
Sugar fermentation stimulation protein C-terminal
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Polysaccharide biosynthesis protein C-terminal
DNA replication/recombination mediator RecO N-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
DNA-directed DNA polymerase family A palm
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Prolyl 3,4-dihydroxylase TPA1/OFD1 N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Plasmid replication protein C N-terminal
Outer membrane protein beta-barrel domain-containing protein
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
O-(5'-phospho-DNA)-tyrosine intermediate
Histidine-specific methyltransferase SAM-dependent
Glycoside hydrolase GH146 substrate-binding
Aminoacyl-transfer RNA synthetases class-II family profile
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Protein O-mannosyl-transferase C-terminal four TM
Beta-hexosaminidase bacterial type N-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
Thymidylate synthase/dCMP hydroxymethylase
Glycine cleavage T-protein C-terminal barrel
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Flagellar basal-body/hook protein C-terminal
ABC-type transport auxiliary lipoprotein component
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Membrane fusion protein biotin-lipoyl like
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Carbamoyl-phosphate synthase small subunit N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Phosphatidylglycerol lysyltransferase C-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Transcription elongation factor GreA/GreB C-terminal
Phosphoadenosine phosphosulphate reductase
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Chromosomal replication initiator protein DnaA
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Calcium-dependent phosphoinositide phospholipase C
Pyrroline-5-carboxylate reductase catalytic N-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Glycosyl transferase family 28 C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Bacterial type II secretion system protein E
Rap1a immunity protein domain-containing protein
Bacterial bifunctional deaminase-reductase C-terminal
Organic solvent tolerance-like N-terminal
RNA 2-O ribose methyltransferase substrate binding
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
C-type lysozyme inhibitor domain-containing protein
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Prepilin type IV endopeptidase peptidase
Magnesium transporter MgtE intracellular
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Glycosyltransferase family 28 N-terminal
Pyrroline-5-carboxylate reductase dimerisation
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Outer membrane protein assembly factor BamA
Type IV secretion system coupling protein TraD DNA-binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
tRNA pseudouridylate synthase B C-terminal
Anthranilate synthase component I N-terminal
Chromosomal replication initiator DnaA C-terminal
DNA mismatch repair proteins mutS family
Alanyl-transfer RNA synthetases family profile
Translation elongation factor P/YeiP central
Tat pathway signal sequence domain protein
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Flagellar motor switch protein FliN-like C-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Nucleophile; cysteine thiosulfonate intermediate
Important for interaction with partner proteins
Beta-xylosidase C-terminal Concanavalin A-like
Polymerase/histidinol phosphatase N-terminal
Small ribosomal subunit protein uS4 N-terminal
Heme-copper oxidase subunit III family profile
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Large ribosomal subunit protein uL2 C-terminal
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Pseudouridine synthase I TruA alpha/beta
Beta-hexosaminidase bacterial type N-terminal domain-containing protein
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Ribose-phosphate pyrophosphokinase N-terminal
Methionyl-tRNA synthetase anticodon-binding
Microcin J25-processing protein McjB C-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Electron transfer via tryptophanyl radical
Large ribosomal subunit protein uL6 alpha-beta
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Release factor glutamine methyltransferase N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Cobaltochelatase subunit CobS N-terminal
Tryptophan synthase beta chain-like PALP
Oligogalacturonate lyase domain-containing protein
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Histidine phosphotransferase ChpT C-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
N-end rule aminoacyl transferase C-terminal
Gylcosyl hydrolase 115 C-terminal domain-containing protein
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Aromatic amino acid beta-eliminating lyase/threonine aldolase
6-phosphogluconate dehydrogenase NADP-binding
Phosphogluconate dehydrogenase NAD-binding putative C-terminal
Superoxide dismutase copper/zinc binding
ATP synthase F1 complex delta/epsilon subunit N-terminal
CagE TrbE VirB component of type IV transporter system central
Glyoxalase/fosfomycin resistance/dioxygenase
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Type II secretion system protein GspG C-terminal
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Required for zinc-mediated homotetramerization and catalytic activity
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Alpha-N-acetylglucosaminidase C-terminal
Alpha-N-acetylglucosaminidase N-terminal
Alpha-N-acetylglucosaminidase tim-barrel
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Polysaccharide biosynthesis protein CapD-like
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
NADH:ubiquinone oxidoreductase 30kDa subunit
Aspartate/homoserine dehydrogenase NAD-binding
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
D-galactarate/Altronate dehydratase C-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Serine aminopeptidase S33 domain-containing protein
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
HTH-type transcriptional regulator MT1864/Rv1816-like C-terminal
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Exonuclease VII large subunit C-terminal
IncF plasmid conjugative transfer protein TraN
Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein
Ribosomal RNA adenine methylase transferase N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Inosine/uridine-preferring nucleoside hydrolase
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Quercetin 2,3-dioxygenase C-terminal cupin
Peptide methionine sulphoxide reductase MsrA
S-adenosylmethionine-dependent methyltransferase
Pyruvate phosphate dikinase AMP/ATP-binding
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
Polysaccharide chain length determinant N-terminal
Chitobiase/beta-hexosaminidases N-terminal
Solute-binding protein family 3/N-terminal
Catalytically important residue that stabilizes the alkoxide intermediate. Moves to point toward the isopeptide bond
Important for activity. Binds to Astexin-3
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Pyridine nucleotide-disulphide oxidoreductase dimerisation
NIF system FeS cluster assembly NifU N-terminal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Phosphoribosylformylglycinamidine synthase linker
Disulphide bond isomerase DsbC/G N-terminal
Proton acceptor; for glutaminase activity
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Metallo-mystery pair system four-Cys motif protein
Sodium/calcium exchanger membrane region
PhoD-like phosphatase metallophosphatase
Putative auto-transporter adhesin head GIN
Proline utilization A proline dehydrogenase N-terminal
Methanolan biosynthesis EpsI domain-containing protein
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Reversibly protonated during proton transport
Alginate lyase domain-containing protein
Dienelactone hydrolase domain-containing protein
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Large ribosomal subunit protein uL15/eL18
Transcriptional regulator AbiEi antitoxin N-terminal
Pilus formation protein N-terminal domain-containing protein
Transcription factor NikR nickel binding C-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
PsbP C-terminal domain-containing protein
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Putative auto-transporter adhesin head GIN domain-containing protein
MotA/TolQ/ExbB proton channel domain-containing protein
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal
Glycoside hydrolase family 42 N-terminal
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Type-F conjugative transfer system protein TraW N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Alpha-D-phosphohexomutase alpha/beta/alpha
Inner membrane protein YgaP-like transmembrane
DNA topoisomerase I catalytic core eukaryotic-type
Essential for prephenate dehydratase activity
Glutathionylspermidine synthase pre-ATP-grasp-like
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Urease accessory protein UreH-like transmembrane
Survival protein SurE-like phosphatase/nucleotidase
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Sialate O-acetylesterase domain-containing protein
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Cytochrome c oxidase subunit IV bacterial aa3 type
Involved in allosteric activation by GTP
Glycine zipper domain-containing protein
Poly-beta-hydroxybutyrate polymerase N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Cysteine sulfenic acid (-SOH) intermediate
Probable periplasmic serine endoprotease DegP-like
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Biopterin-dependent aromatic amino acid hydroxylase family profile
NAD(P) transhydrogenase alpha subunit C-terminal
Terminase large subunit-like endonuclease