tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Methionyl-tRNA synthetase anticodon-binding
Pyridine nucleotide-disulphide oxidoreductase dimerisation
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
RNA 2-O ribose methyltransferase substrate binding
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
RNA polymerase sigma factor 70 region 4 type 2
Essential for prephenate dehydratase activity
6-phosphogluconate dehydrogenase C-terminal
Capsule synthesis protein CapA domain-containing protein
Major facilitator superfamily (MFS) profile
Cell envelope-related transcriptional attenuator
Pyridoxamine 5'-phosphate oxidase putative
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Mandelate racemase/muconate lactonizing enzyme C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Phosphoadenosine phosphosulphate reductase
1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Solute-binding protein family 3/N-terminal
Abolished formylglycine-generating enzyme activity and ability to bind Cu(+).
In 4C; increased formylglycine-generating enzyme activity; when associated with A-187; A-231 and A-284.
In 4C; increased formylglycine-generating enzyme activity; when associated with A-187; A-231 and A-298.
In 4C; increased formylglycine-generating enzyme activity; when associated with A-187; A-284 and A-298.
In 4C; increased formylglycine-generating enzyme activity; when associated with A-231; A-284 and A-298.
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Tryptophan synthase beta chain-like PALP
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
O-(5'-phospho-DNA)-tyrosine intermediate
Gram-positive cocci surface proteins LPxTG domain-containing protein
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
CobB/CobQ-like glutamine amidotransferase
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Bacterial transcription activator effector binding
Thiamine pyrophosphate enzyme TPP-binding
Plays an important role in substrate specificity
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Peptidoglycan recognition protein family
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Large ribosomal subunit protein uL2 C-terminal
Glycosyl transferase family 3 N-terminal
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
NADH:ubiquinone oxidoreductase 30kDa subunit
ATP synthase F1 complex delta/epsilon subunit N-terminal
Transcription regulator AsnC/Lrp ligand binding
Ribosomal RNA adenine methylase transferase N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Cysteine sulfenic acid (-SOH) intermediate
Putative adhesin domain-containing protein
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Penicillin-binding protein transpeptidase
Polysaccharide chain length determinant N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Putative regulatory protein FmdB Zinc ribbon
Schiff-base intermediate with substrate; via pyruvic acid
Large ribosomal subunit protein uL30-like ferredoxin-like fold
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Biopterin-dependent aromatic amino acid hydroxylase family profile
Pyruvate phosphate dikinase AMP/ATP-binding
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Interaction with polymerase core subunit RpoC
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Putative oxidoreductase/dehydrogenase Rossmann-like
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Cation-transporting P-type ATPase N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Increased intrinsic ATPase activity without concentration-dependency; when associated with A-543.
Increased intrinsic ATPase activity; ATPase is activated by wild-type but not mutant EsxBA-98.
No longer activates ATPase; when associated with A-543.
NIF system FeS cluster assembly NifU N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Alpha-glycerophosphate oxidase C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Tetracyclin repressor-like C-terminal group 31
NADH-rubredoxin oxidoreductase C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Bacterial type II secretion system protein E
Pyrimidine nucleoside phosphorylase C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Translation elongation factor SelB winged helix type 3
Phosphocysteine intermediate; for EIIB activity
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
11-fold decrease in catalytic efficiency.
13-fold decrease in catalytic efficiency.
322-fold decrease in catalytic efficiency. Loss of activity; when associated with F-294.
Almost loss of activity. Loss of activity; when associated with F-344.
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Increases nucleophilicity of active site Cys
Lipocalin-like domain-containing protein
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Glycine cleavage T-protein C-terminal barrel
Peptidase M43 pregnancy-associated plasma-A
Polymerase/histidinol phosphatase N-terminal
DNA-directed DNA polymerase family A palm
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Na+/H+ antiporter MnhB subunit-related protein
Aconitase A/isopropylmalate dehydratase small subunit swivel
Exonuclease VII large subunit C-terminal
Alanyl-transfer RNA synthetases family profile
Electron transfer flavoprotein alpha/beta-subunit N-terminal
D-inositol 3-phosphate glycosyltransferase
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Thiopeptide-type bacteriocin biosynthesis
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Shikimate dehydrogenase substrate binding N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Erythromycin biosynthesis protein CIII-like central
Large ribosomal subunit protein uL6 alpha-beta
Tat pathway signal sequence domain protein
Proton acceptor; for glutaminase activity
Pyrroline-5-carboxylate reductase catalytic N-terminal
Glucose-methanol-choline oxidoreductase C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Large ribosomal subunit protein uL15/eL18
Prokaryotic-type class I peptide chain release factors
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Moybdenum cofactor oxidoreductase dimerisation
Nucleophile; cysteine thiosulfonate intermediate
Peptidase M1 membrane alanine aminopeptidase
Glucose-methanol-choline oxidoreductase N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Chromosomal replication initiator DnaA C-terminal
Helix-hairpin-helix DNA-binding motif class 1
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
AFL C-terminal domain-containing protein
Adaptive response protein AidB N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
vWA-MoxR associated protein middle region 0
Butirosin biosynthesis protein H N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Polysaccharide biosynthesis protein C-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Histidine-specific methyltransferase SAM-dependent
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Cytochrome b/b6 N-terminal region profile
Probable enoyl-CoA hydratase alpha subunit
PhoD-like phosphatase metallophosphatase
Heat-inducible transcription repressor HrcA C-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Ribulose bisphosphate carboxylase small subunit
2,4-diaminopentanoate dehydrogenase C-terminal
Cell wall-active antibiotics response LiaF-like C-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-111)
Docks into pockets in the proteasome alpha-ring
Anthranilate synthase component I N-terminal
Cytochrome C biogenesis protein transmembrane
Reversibly protonated during proton transport
AMP-activated protein kinase glycogen-binding
Endoribonuclease L-PSP/chorismate mutase-like
Positions MEP for the nucleophilic attack
Conserved hypothetical protein CHP02679 N terminus
ABC-type glycine betaine transport system substrate-binding
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Acetylserotonin O-methyltransferase dimerisation
Myo-inositol-1-phosphate synthase GAPDH-like
Phosphatidic acid phosphatase type 2/haloperoxidase
Translation elongation factor P/YeiP central
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
Release factor glutamine methyltransferase N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Carbamoyl-phosphate synthase small subunit N-terminal
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Sporulation transcription regulator WhiA N-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
SUF system FeS cluster assembly SufBD N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Removed in mature form; by autocatalysis