Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Cation-transporting P-type ATPase N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Electron transfer via tryptophanyl radical
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Glycosyltransferase subfamily 4-like N-terminal
Membrane fusion protein biotin-lipoyl like
Glucan biosynthesis periplasmic MdoG C-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
RNA 2-O ribose methyltransferase substrate binding
Major facilitator superfamily (MFS) profile
Bacterial type II secretion system protein E
Aminoacyl-transfer RNA synthetases class-II family profile
TonB-dependent receptor-like beta-barrel
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Type VI secretion system (T6SS) amidase immunity protein Tai4
Thymidylate synthase/dCMP hydroxymethylase
Fimbrial-type adhesion domain-containing protein
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Important for beta-aspartyl-AMP intermediate formation
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Chromosomal replication initiator DnaA C-terminal
Ion-translocating oxidoreductase complex subunit G
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Tryptophan synthase beta chain-like PALP
Chromosome partition protein MukF C-terminal
Chromosome partition protein MukF middle
Chromosome partition protein MukF winged-helix
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Polysaccharide chain length determinant N-terminal
Essential for prephenate dehydratase activity
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Lysozyme inhibitor LprI N-terminal domain-containing protein
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Type VI secretion system IcmF C-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Peptide methionine sulphoxide reductase MsrA
Important for substrate binding and specificity
Regulator of nucleoside diphosphate kinase N-terminal
Glycosyl transferase family 3 N-terminal
Required for zinc-mediated homotetramerization and catalytic activity
Schiff-base intermediate with substrate; via pyruvic acid
Outer membrane protein assembly factor BamE
Alanyl-transfer RNA synthetases family profile
Alpha-D-phosphohexomutase alpha/beta/alpha
Acyltransferase MbtK/IucB-like conserved
Outer membrane assembly lipoprotein YfiO
Pyruvate phosphate dikinase AMP/ATP-binding
Threonine/serine exporter-like N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Prokaryotic-type class I peptide chain release factors
Acyl-ester intermediate; for transpeptidase activity
Penicillin-binding protein transpeptidase
Proton donor; for transglycosylase activity
Transglycosylase PBP1b N-terminal transmembrane
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Glycosyl transferase family 28 C-terminal
Type VI secretion system-associated protein
O-(3'-phospho-DNA)-tyrosine intermediate
Multiple antibiotic resistance protein MarB
Sodium/calcium exchanger membrane region
Quercetin 2,3-dioxygenase C-terminal cupin
Type III secretion system flagellar brake protein YcgR PilZN
Gly-cisPro motif, important for rejection of L-amino acids
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Interaction with polymerase core subunit RpoC
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Prepilin peptidase dependent protein C-like C-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Adaptive response protein AidB N-terminal
Large ribosomal subunit protein bL25 L25
Menaquinone biosynthesis protein MenD middle
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Glucosamine/galactosamine-6-phosphate isomerase
Reversibly protonated during proton transport
Tetrahydrodipicolinate-N-succinyltransferase chain A
Phosphatidic acid phosphatase type 2/haloperoxidase
YdgH/BhsA/McbA-like domain-containing protein
Capsule biosynthesis GfcC-like C-terminal
Capsule biosynthesis GfcC-like N-terminal
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Pseudouridine synthase I TruA alpha/beta
Schiff-base intermediate with acetaldehyde
Terminase large subunit-like endonuclease
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Outer membrane protein assembly factor BamD
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Non-canonical purine NTP phosphatase/PRRC1
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Phosphocysteine intermediate; for EIIB activity
NIF system FeS cluster assembly NifU C-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Exonuclease VII large subunit C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Required for dimer formation and molybdate binding
Could play a key role in the communication between the regulatory and the substrate sites
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Integral membrane protein YccS N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
N6 adenine-specific DNA methyltransferase N-terminal
Glycosyltransferase family 28 N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
RND efflux pump membrane fusion protein barrel-sandwich
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Plays an important role in substrate specificity
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Cob(I)alamin adenosyltransferase N-terminal
Methylguanine DNA methyltransferase ribonuclease-like
Ribose-phosphate pyrophosphokinase N-terminal
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
RNA methyltransferase SpoU/TrmH type C-terminal
Flagella basal body P-ring formation protein FlgA
6-phosphogluconate dehydrogenase C-terminal
Essential for degradation by Lon protease
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Seems to be a necessary countercharge to the potassium cations
ABC-type glycine betaine transport system substrate-binding
Terminase large subunit gp17-like C-terminal
Heme-copper oxidase subunit III family profile
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Alpha-glycerophosphate oxidase C-terminal
Disulphide bond isomerase DsbC/G N-terminal
Translation elongation factor P/YeiP central
Outer membrane protein assembly factor BamB
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
DNA-3-methyladenine glycosylase AlkA N-terminal
Aspartate/homoserine dehydrogenase NAD-binding
Large ribosomal subunit protein uL15/eL18
Flagellar motor switch protein FliN-like C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Organic solvent tolerance-like N-terminal
Outer-membrane lipoprotein carrier protein
TRAP C4-dicarboxylate transport system permease DctM subunit
Glutathionylspermidine synthase pre-ATP-grasp-like
Nucleoside-specific channel-forming protein Tsx
Gp5/Type VI secretion system Vgr protein OB-fold
Pyruvate dehydrogenase E1 component middle
Greasy slide, important in sugar transport
Flagellar motor switch protein FliN N-terminal
Helix-hairpin-helix DNA-binding motif class 1
DnaJ homologue subfamily C member 28 conserved
Type I restriction modification DNA specificity
Involved in tetramerization or stability of the tetramer
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
YbaK/aminoacyl-tRNA synthetase-associated
Thiol:disulfide interchange protein DsbD
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Bacterial transcription activator effector binding
Involved in allosteric activation by GTP
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Could be important to modulate the pK values of the two catalytic cysteine residues
Large ribosomal subunit protein uL6 alpha-beta
UDP N-acetylglucosamine O-acyltransferase C-terminal
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Molybdopterin cofactor biosynthesis C (MoaC)
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Polymerase/histidinol phosphatase N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Putative type VI secretion system Rhs element associated Vgr
Glycoside hydrolase family 42 N-terminal
ABC-type transport auxiliary lipoprotein component
Arabinogalactan endo-beta-1,4-galactanase
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Flagellar hook-length control protein-like C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
Glycine cleavage T-protein C-terminal barrel
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
DNA polymerase III delta subunit C-terminal
Periplasmic binding protein/LacI sugar binding
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
Phosphoadenosine phosphosulphate reductase
Curli production assembly/transport component CsgF
Release factor glutamine methyltransferase N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Nucleophile; cysteine thiosulfonate intermediate
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Curli production assembly/transport component CsgG
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Antitoxin Xre/MbcA/ParS-like toxin-binding
L-seryl-tRNA selenium transferase N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Rap1a immunity protein domain-containing protein
Ribosomal RNA adenine methylase transferase N-terminal
Transcriptional regulator SgrR N-terminal HTH
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
DNA polymerase III subunit delta C-terminal
Serine/threonine specific protein phosphatases
Large ribosomal subunit protein uL30-like ferredoxin-like fold
D-galactose/methyl-galactoside binding periplasmic protein MglB
DNA replication/recombination mediator RecO N-terminal
O-(phosphoribosyl dephospho-coenzyme A)serine
Moves into active site upon enzyme activation, plays a role in electron transfer
Large ribosomal subunit protein uL2 C-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Translocation and assembly module subunit TamA
Positions MEP for the nucleophilic attack
Penicillin-binding protein activator LpoB
Phosphotransferase system enzyme I N-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Resolvase/invertase-type recombinase catalytic
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Cysteine sulfenic acid (-SOH) intermediate
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Glucose-methanol-choline oxidoreductase N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Important for interaction with partner proteins
Appears to be important in orienting the phosphate for catalysis
RNA polymerase sigma factor 70 region 4 type 2
Nicotinamide phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Inosine/uridine-preferring nucleoside hydrolase
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Mannose-6-phosphate isomerase type II C-terminal
Survival protein SurE-like phosphatase/nucleotidase
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
NIF system FeS cluster assembly NifU N-terminal
Tellurite resistance methyltransferase TehB-like
Glycoside hydrolase family 31 N-terminal
Penicillin-insensitive murein endopeptidase
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Erythronate-4-phosphate dehydrogenase dimerisation
Curli production assembly/transport component CsgE