Genome sequence of the nematode C. elegans: a platform for investigating biology.
Polycomb-like genes are necessary for specification of dopaminergic and serotonergic neurons in Caenorhabditis elegans.
Study of the nematode putative GABA type-A receptor subunits: evidence for modulation by ivermectin.
2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans.
The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans.
Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins.
Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.
A conserved retromer-independent function for RAB-6.2 in C. elegans epidermis integrity.
RAB-6.1 and RAB-6.2 Promote Retrograde Transport in C. elegans.
RAB-6.2 and the retromer regulate glutamate receptor recycling through a retrograde pathway.
Rab6 is required for the exocytosis of cortical granules and the recruitment of separase to the granules during the oocyte-to-embryo transition in Caenorhabditis elegans.
The Caenorhabditis elegans GARP complex contains the conserved Vps51 subunit and is required to maintain lysosomal morphology.
The RabGAP TBC-11 controls Argonaute localization for proper microRNA function in C. elegans.
The jaw of the worm: GTPase-activating protein EAT-17 regulates grinder formation in Caenorhabditis elegans.
Expression of a CIC chloride channel in Caenorhabditis elegans gamma-aminobutyric acid-ergic neurons.
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.
Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions.
The presenilin protein family member SPE-4 localizes to an ER/Golgi derived organelle and is required for proper cytoplasmic partitioning during Caenorhabditis elegans spermatogenesis.
The zinc transporter ZIPT-7.1 regulates sperm activation in nematodes.
BBS4 and BBS5 show functional redundancy in the BBSome to regulate the degradative sorting of ciliary sensory receptors.
The BBSome controls IFT assembly and turnaround in cilia.
Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell-death execution pathways downstream of ced-3 and independent of ced-9.
Effects of mutations in mitochondrial dynamics-related genes on the mitochondrial response to ultraviolet C radiation in developing Caenorhabditis elegans.
Mutations in Fis1 disrupt orderly disposal of defective mitochondria.
The homeoproteins MAB-18 and CEH-14 insulate the dauer collagen gene col-43 from activation by the adjacent promoter of the Spermatheca gene sth-1 in Caenorhabditis elegans.
A conserved nuclear cyclophilin is required for both RNA polymerase II elongation and co-transcriptional splicing in Caenorhabditis elegans.
The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae.
The Caenorhabditis elegans JNK signaling pathway activates expression of stress response genes by derepressing the Fos/HDAC repressor complex.
A novel zinc-carboxypeptidase SURO-1 regulates cuticle formation and body morphogenesis in Caenorhabditis elegans.
Cuticle Collagen Expression Is Regulated in Response to Environmental Stimuli by the GATA Transcription Factor ELT-3 in Caenorhabditis elegans.
The Caenorhabditis elegans rol-6 gene, which interacts with the sqt-1 collagen gene to determine organismal morphology, encodes a collagen.
Mutational analysis of bli-4/kpc-4 reveals critical residues required for proprotein convertase function in C. elegans.
Neuropeptide signaling remodels chemosensory circuit composition in Caenorhabditis elegans.
The bli-4 locus of Caenorhabditis elegans encodes structurally distinct kex2/subtilisin-like endoproteases essential for early development and adult morphology.
The kunitz domain protein BLI-5 plays a functionally conserved role in cuticle formation in a diverse range of nematodes.
Evidence for the frequent use of TTG as the translation initiation codon of mitochondrial protein genes in the nematodes, Ascaris suum and Caenorhabditis elegans.
Muller's Ratchet and compensatory mutation in Caenorhabditis briggsae mitochondrial genome evolution.
Mutations in mitochondrial complex III uniquely affect complex I in Caenorhabditis elegans.
Phylogenetics in Caenorhabditis elegans: an analysis of divergence and outcrossing.
The mitochondrial genomes of two nematodes, Caenorhabditis elegans and Ascaris suum.
ADBP-1 regulates an ADAR RNA-editing enzyme to antagonize RNA-interference-mediated gene silencing in Caenorhabditis elegans.
C. elegans and H. sapiens mRNAs with edited 3' UTRs are present on polysomes.
Caenorhabditis elegans mRNAs that encode a protein similar to ADARs derive from an operon containing six genes.
Mutations in RNAi rescue aberrant chemotaxis of ADAR mutants.
Profiling the RNA editomes of wild-type C. elegans and ADAR mutants.
RNA editing by ADARs is important for normal behavior in Caenorhabditis elegans.
RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans.
The C. elegans neural editome reveals an ADAR target mRNA required for proper chemotaxis.
The dsRBP and inactive editor ADR-1 utilizes dsRNA binding to regulate A-to-I RNA editing across the C. elegans transcriptome.
The role of RNA editing by ADARs in RNAi.
Differential expression of glutamate receptor subunits in the nervous system of Caenorhabditis elegans and their regulation by the homeodomain protein UNC-42.
Genes that guide growth cones along the C. elegans ventral nerve cord.
The C. elegans homeodomain gene unc-42 regulates chemosensory and glutamate receptor expression.
The C. elegans nuclear receptor gene fax-1 and homeobox gene unc-42 coordinate interneuron identity by regulating the expression of glutamate receptor subunits and other neuron-specific genes.
The Prop1-like homeobox gene unc-42 specifies the identity of synaptically connected neurons.
Endocytic sorting and recycling require membrane phosphatidylserine asymmetry maintained by TAT-1/CHAT-1.
The temporally regulated transcription factor sel-7 controls developmental timing in C. elegans.
sel-7, a positive regulator of lin-12 activity, encodes a novel nuclear protein in Caenorhabditis elegans.
Betaine acts on a ligand-gated ion channel in the nervous system of the nematode C. elegans.
Novel alpha7-like nicotinic acetylcholine receptor subunits in the nematode Caenorhabditis elegans.
acr-23 encodes a monepantel-sensitive channel in Caenorhabditis elegans.
A C. elegans sperm TRP protein required for sperm-egg interactions during fertilization.
Cloning and characterization of the C. elegans histidyl-tRNA synthetase gene.
GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.
Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome.
A map of the interactome network of the metazoan C. elegans.
Asymmetric division: a kinesin for spindle positioning.
Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans.
Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions.
Kinesin-1 mediates translocation of the meiotic spindle to the oocyte cortex through KCA-1, a novel cargo adapter.
Life extension and stress resistance in Caenorhabditis elegans modulated by the tkr-1 gene.
The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans.
Genomic structure and chromosomal localization of human thioredoxin-like protein gene (txl).
Analysis of dominant mutations affecting muscle excitation in Caenorhabditis elegans.
Caenorhabditis elegans DNA mismatch repair gene msh-2 is required for microsatellite stability and maintenance of genome integrity.
Caenorhabditis elegans SWI/SNF subunits control sequential developmental stages in the somatic gonad.
Functional Interplay of Two Paralogs Encoding SWI/SNF Chromatin-Remodeling Accessory Subunits During Caenorhabditis elegans Development.
LDB1 and the SWI/SNF complex participate in both transcriptional activation and repression by Caenorhabditis elegans BLIMP1/PRDM1.
The SWI/SNF chromatin remodeling complex selectively affects multiple aspects of serotonergic neuron differentiation.
Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor, regulating C. elegans development and lifespan.
Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan.
Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans.
TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone.
New insulin-like proteins with atypical disulfide bond pattern characterized in Caenorhabditis elegans by comparative sequence analysis and homology modeling.
The identification of a novel mutant allele of topoisomerase II in Caenorhabditis elegans reveals a unique role in chromosome segregation during spermatogenesis.
cin-4, a gene with homology to topoisomerase II, is required for centromere resolution by cohesin removal from sister kinetochores during mitosis.
A novel bipartite UNC-101/AP-1 mu1 binding signal mediates KVS-4/Kv2.1 somatodendritic distribution in Caenorhabditis elegans.
Functional coordination of WAVE and WASP in C. elegans neuroblast migration.
MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis elegans.
MIG-13 positions migrating cells along the anteroposterior body axis of C. elegans.
Neuronal cell migration in C. elegans: regulation of Hox gene expression and cell position.
SDN-1/Syndecan acts in parallel to the transmembrane molecule MIG-13 to promote anterior neuroblast migration.
The roles of two C. elegans HOX co-factor orthologs in cell migration and vulva development.
Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration.
Altered DNA damage response in Caenorhabditis elegans with impaired poly(ADP-ribose) glycohydrolases genes expression.
Lipocalin signaling controls unicellular tube development in the Caenorhabditis elegans excretory system.
A mutation in a mitochondrial dehydrogenase/reductase gene causes an increased sensitivity to oxidative stress and mitochondrial defects in the nematode Caenorhabditis elegans.
Molecular mechanisms of bacterial virulence elucidated using a Pseudomonas aeruginosa-Caenorhabditis elegans pathogenesis model.
Radiation-sensitive mutants of Caenorhabditis elegans.
The effects of temperature on the longevity of a radiation-sensitive mutant rad-8 of the nematode Caenorhabditis elegans.
The radiation-sensitive mutant rad-8 of Caenorhabditis elegans is hypersensitive to the effects of oxygen on aging and development.
The tumor suppressor BCL7B functions in the Wnt signaling pathway.
DAF-5 is a Ski oncoprotein homolog that functions in a neuronal TGF beta pathway to regulate C. elegans dauer development.
N-glycosylation is required for secretion and mitosis in C. elegans.
dad-1, an endogenous programmed cell death suppressor in Caenorhabditis elegans and vertebrates.
Member of the membrane-bound O-acyltransferase (MBOAT) family encodes a lysophospholipid acyltransferase with broad substrate specificity.
The fmo genes of Caenorhabditis elegans and C. briggsae: characterisation, gene expression and comparative genomic analysis.
Rapid expression screening of Caenorhabditis elegans homeobox open reading frames using a two-step polymerase chain reaction promoter-gfp reporter construction technique.
Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes.
The MAP kinase JNK-1 of Caenorhabditis elegans: location, activation, and influences over temperature-dependent insulin-like signaling, stress responses, and fitness.
The manganese superoxide dismutase gene of Caenorhabditis elegans.
Genomic organization, expression, and analysis of the troponin C gene pat-10 of Caenorhabditis elegans.
Incenp and an aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis.
A Novel Sperm-Delivered Toxin Causes Late-Stage Embryo Lethality and Transmission Ratio Distortion in C. elegans.
An extensive and diverse gene family of nicotinic acetylcholine receptor alpha subunits in Caenorhabditis elegans.
Transcription factor hlh-2/E/Daughterless drives expression of alpha integrin ina-1 during DTC migration in C. elegans.
bHLH transcription factors regulate organ morphogenesis via activation of an ADAMTS protease in C. elegans.
Four subunit a isoforms of Caenorhabditis elegans vacuolar H+-ATPase. Cell-specific expression during development.
Loss of the apical V-ATPase a-subunit VHA-6 prevents acidification of the intestinal lumen during a rhythmic behavior in C. elegans.
The mRNA Decay Factor CAR-1/LSM14 Regulates Axon Regeneration via Mitochondrial Calcium Dynamics.
Deoxyribonuclease II: structure and chromosomal localization of the murine gene, and comparison with the genomic structure of the human and three C. elegans homologs.
Functional genomic analysis of apoptotic DNA degradation in C. elegans.
A bow-tie genetic architecture for morphogenesis suggested by a genome-wide RNAi screen in Caenorhabditis elegans.
Asymmetric cortical and nuclear localizations of WRM-1/beta-catenin during asymmetric cell division in C. elegans.
Binary specification of the embryonic lineage in Caenorhabditis elegans.
C. elegans pur alpha, an activator of end-1, synergizes with the Wnt pathway to specify endoderm.
Identification of C. elegans DAF-12-binding sites, response elements, and target genes.
Left-right asymmetry in C. elegans intestine organogenesis involves a LIN-12/Notch signaling pathway.
MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans.
MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans.
Phosphorylation by the beta-catenin/MAPK complex promotes 14-3-3-mediated nuclear export of TCF/POP-1 in signal-responsive cells in C. elegans.
WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans.
The Caenorhabditis elegans ortholog of human PHF5a shows a muscle-specific expression domain and is essential for C. elegans morphogenetic development.
Comparisons of the complete sequences of two collagen genes from Caenorhabditis elegans.
Expression of the Caenorhabditis elegans collagen genes col-1 and col-2 is developmentally regulated.
Gene interactions in Caenorhabditis elegans define DPY-31 as a candidate procollagen C-proteinase and SQT-3/ROL-4 as its predicted major target.
A specific set of exon junction complex subunits is required for the nuclear retention of unspliced RNAs in Caenorhabditis elegans.
An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation.
UAP56 levels affect viability and mRNA export in Caenorhabditis elegans.
Kinetic characterization and thermostability of C. elegans cytoplasmic and mitochondrial malate dehydrogenases.
Discoidin domain receptors guide axons along longitudinal tracts in C. elegans.
N-Glycosylation of the Discoidin Domain Receptor Is Required for Axon Regeneration in Caenorhabditis elegans.
The C. elegans discoidin domain receptor DDR-2 modulates the Met-like RTK-JNK signaling pathway in axon regeneration.
C. elegans Tensin Promotes Axon Regeneration by Linking the Met-like SVH-2 and Integrin Signaling Pathways.
C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons.
Caenorhabditis elegans has scores of homoeobox-containing genes.
Diversification of C. elegans Motor Neuron Identity via Selective Effector Gene Repression.
Dominant unc-37 mutations suppress the movement defect of a homeodomain mutation in unc-4, a neural specificity gene in Caenorhabditis elegans.
Expression of the unc-4 homeoprotein in Caenorhabditis elegans motor neurons specifies presynaptic input.
Regulation of neurotransmitter vesicles by the homeodomain protein UNC-4 and its transcriptional corepressor UNC-37/groucho in Caenorhabditis elegans cholinergic motor neurons.
Sustained expression of unc-4 homeobox gene and unc-37/Groucho in postmitotic neurons specifies the spatial organization of the cholinergic synapses in C. elegans.
The Groucho-like transcription factor UNC-37 functions with the neural specificity gene unc-4 to govern motor neuron identity in C. elegans.
UNC-4 antagonizes Wnt signaling to regulate synaptic choice in the C. elegans motor circuit.
UNC-4 represses CEH-12/HB9 to specify synaptic inputs to VA motor neurons in C. elegans.
UNC-4/UNC-37-dependent repression of motor neuron-specific genes controls synaptic choice in Caenorhabditis elegans.
The Caenorhabditis elegans Skp1-related gene family: diverse functions in cell proliferation, morphogenesis, and meiosis.
An ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes GPCR maturation by a Ufm1-independent mechanism.
Odorant receptor localization to olfactory cilia is mediated by ODR-4, a novel membrane-associated protein.
Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli.
Structural basis for Ufm1 recognition by UfSP.
The ubiquitin-fold modifier 1 (Ufm1) cascade of Caenorhabditis elegans.
A Krueppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans.
A conserved ubiquitination pathway determines longevity in response to diet restriction.
WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans.
Searching for neuronal left/right asymmetry: genomewide analysis of nematode receptor-type guanylyl cyclases.
The C. elegans cGMP-dependent protein kinase EGL-4 regulates nociceptive behavioral sensitivity.
Thioredoxin shapes the C. elegans sensory response to Pseudomonas produced nitric oxide.
Alternative splicing of the muscarinic acetylcholine receptor GAR-3 in Caenorhabditis elegans.
Behavioral impact of neurotransmitter-activated G-protein-coupled receptors: muscarinic and GABAB receptors regulate Caenorhabditis elegans locomotion.
Cloning and functional characterization of a Caenorhabditis elegans muscarinic acetylcholine receptor.
EGG-4 and EGG-5 Link Events of the Oocyte-to-Embryo Transition with Meiotic Progression in C. elegans.
Regulation of MBK-2/DYRK by CDK-1 and the pseudophosphatases EGG-4 and EGG-5 during the oocyte-to-embryo transition.
2.6 A resolution crystal structure of helices of the motile major sperm protein (MSP) of Caenorhabditis elegans.
Characterization of Caenorhabditis elegans Nucleosome Assembly Protein 1 Uncovers the Role of Acidic Tails in Histone Binding.
Developmental defects in a Caenorhabditis elegans model for type III galactosemia.
H+/myo-inositol transporter genes, hmit-1.1 and hmit-1.2, have roles in the osmoprotective response in Caenorhabditis elegans.
Discovering neuropeptides in Caenorhabditis elegans by two dimensional liquid chromatography and mass spectrometry.
Expression and regulation of an FMRFamide-related neuropeptide gene family in Caenorhabditis elegans.
Role of a FMRFamide-like family of neuropeptides in the pharyngeal nervous system of Caenorhabditis elegans.
Lifespan decrease in a Caenorhabditis elegans mutant lacking TRX-1, a thioredoxin expressed in ASJ sensory neurons.
TRX-1 Regulates SKN-1 Nuclear Localization Cell Non-autonomously in Caenorhabditis elegans.
The thioredoxin TRX-1 modulates the function of the insulin-like neuropeptide DAF-28 during dauer formation in Caenorhabditis elegans.
The thioredoxin TRX-1 regulates adult lifespan extension induced by dietary restriction in Caenorhabditis elegans.
Thioredoxin is related to life span regulation and oxidative stress response in Caenorhabditis elegans.
Use of an activated beta-catenin to identify Wnt pathway target genes in caenorhabditis elegans, including a subset of collagen genes expressed in late larval development.
OSM-11 facilitates LIN-12 Notch signaling during Caenorhabditis elegans vulval development.
The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins.
Functional Proteomics Identifies a PICS Complex Required for piRNA Maturation and Chromosome Segregation.
PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability.
Identification and characterization of Caenorhabditis elegans RNAi inheritance machinery.
Identification and molecular-genetic characterization of a LAMP/CD68-like protein from Caenorhabditis elegans.
Nucleotide sequences of Caenorhabditis elegans core histone genes. Genes for different histone classes share common flanking sequence elements.
Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation.
The enhancement of histone H4 and H2A serine 1 phosphorylation during mitosis and S-phase is evolutionarily conserved.
The primary structure of histone H2A from the nematode Caenorhabditis elegans.
Binding specificity and function of the SWI/SNF subunit SMARCA4 bromodomain interaction with acetylated histone H3K14.
Caenorhabditis elegans RBX1 is essential for meiosis, mitotic chromosomal condensation and segregation, and cytokinesis.
Germline X chromosomes exhibit contrasting patterns of histone H3 methylation in Caenorhabditis elegans.
Meiotic pairing and imprinted X chromatin assembly in Caenorhabditis elegans.
Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes.
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.
Role of Caenorhabditis elegans protein phosphatase type 1, CeGLC-7 beta, in metaphase to anaphase transition during embryonic development.
The C. elegans Tousled-like kinase (TLK-1) has an essential role in transcription.
The MES-2/MES-3/MES-6 complex and regulation of histone H3 methylation in C. elegans.
The aurora B kinase AIR-2 regulates kinetochores during mitosis and is required for separation of homologous Chromosomes during meiosis.
The primary structure of histone H3 from the nematode Caenorhabditis elegans.
X-chromosome silencing in the germline of C. elegans.
Caenorhabditis elegans UBX cofactors for CDC-48/p97 control spermatogenesis.
Differential expression pattern of UBX family genes in Caenorhabditis elegans.
Functional characterization of UBXN-6, a C-terminal cofactor of CDC-48, in C. elegans.
Lifespan regulation by evolutionarily conserved genes essential for viability.
Molting-specific downregulation of C. elegans body-wall muscle attachment sites: the role of RNF-5 E3 ligase.
The LIM domain protein UNC-95 is required for the assembly of muscle attachment structures and is regulated by the RING finger protein RNF-5 in C. elegans.
Genetic dissection of polyunsaturated fatty acid synthesis in Caenorhabditis elegans.
Identification of a caenorhabditis elegans Delta6-fatty-acid-desaturase by heterologous expression in saccharomyces cerevisiae.
Polyunsaturated fatty acids influence synaptojanin localization to regulate synaptic vesicle recycling.
The cytochrome b5 reductase HPO-19 is required for biosynthesis of polyunsaturated fatty acids in Caenorhabditis elegans.
Human alpha- and beta-NRXN1 isoforms rescue behavioral impairments of Caenorhabditis elegans neurexin-deficient mutants.
MSP domain proteins show enhanced expression in male germ line cells.
Programmed elimination of cells by caspase-independent cell extrusion in C. elegans.
A palmitoyl-CoA-specific delta9 fatty acid desaturase from Caenorhabditis elegans.
Genetic regulation of unsaturated fatty acid composition in C. elegans.
Identification of cytochrome b5 CYTB-5.1 and CYTB-5.2 in C. elegans; evidence for differential regulation of SCD.
Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans.
The chromosome axis controls meiotic events through a hierarchical assembly of HORMA domain proteins.
A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors.
Branched-chain amino acid catabolism is a conserved regulator of physiological ageing.
Redox-mediated regulation of aging and healthspan by an evolutionarily conserved transcription factor HLH-2/Tcf3/E2A.
The primary structure of histone H4 from the nematode Caenorhabditis elegans.
FGT-1 is a mammalian GLUT2-like facilitative glucose transporter in Caenorhabditis elegans whose malfunction induces fat accumulation in intestinal cells.
FGT-1 is the major glucose transporter in C. elegans and is central to aging pathways.
The Zona Pellucida domain containing proteins, CUT-1, CUT-3 and CUT-5, play essential roles in the development of the larval alae in Caenorhabditis elegans.
A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation.
Coordinated regulation of active and repressive histone methylations by a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans.
H3K23me2 is a new heterochromatic mark in Caenorhabditis elegans.
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases.
Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans.
Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity.
Eukaryotic initiation factor EIF-3.G augments mRNA translation efficiency to regulate neuronal activity.
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi.
The RFamide receptor DMSR-1 regulates stress-induced sleep in C. elegans.
A C. elegans CLIC-like protein required for intracellular tube formation and maintenance.
Comparison of vertebrate and invertebrate CLIC proteins: the crystal structures of Caenorhabditis elegans EXC-4 and Drosophila melanogaster DmCLIC.
The rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission.
BBLN-1 is essential for intermediate filament organization and apical membrane morphology.
Caenorhabditis elegans lin-35/Rb, efl-1/E2F and other synthetic multivulva genes negatively regulate the anaphase-promoting complex gene mat-3/APC8.
Components of the spindle assembly checkpoint regulate the anaphase-promoting complex during meiosis in Caenorhabditis elegans.
Metaphase to anaphase (mat) transition-defective mutants in Caenorhabditis elegans.
Multiple subunits of the Caenorhabditis elegans anaphase-promoting complex are required for chromosome segregation during meiosis I.
The anaphase-promoting complex (APC) ubiquitin ligase regulates GABA transmission at the C. elegans neuromuscular junction.
The anaphase-promoting complex and separin are required for embryonic anterior-posterior axis formation.
The anaphase-promoting complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans.
Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway.
Juniperonic Acid Biosynthesis is Essential in Caenorhabditis Elegans Lacking Delta6 Desaturase (fat-3) and Generates New omega-3 Endocannabinoids.
Complementary expression patterns of six nonessential Caenorhabditis elegans core 2/I N-acetylglucosaminyltransferase homologues.
Caenorhabditis elegans glutamylating enzymes function redundantly in male mating.
Glutamylation Regulates Transport, Specializes Function, and Sculpts the Structure of Cilia.
Identification of tubulin deglutamylase among Caenorhabditis elegans and mammalian cytosolic carboxypeptidases (CCPs).
CCDC-55 is required for larval development and distal tip cell migration in Caenorhabditis elegans.
High-throughput in vivo analysis of gene expression in Caenorhabditis elegans.
A transcriptional program promotes remodeling of GABAergic synapses in Caenorhabditis elegans.
Transcriptional control of parallel-acting pathways that remove specific presynaptic proteins in remodeling neurons.
Transcriptional control of synaptic remodeling through regulated expression of an immunoglobulin superfamily protein.
The astacin protein family in Caenorhabditis elegans.
EGG-3 regulates cell-surface and cortex rearrangements during egg activation in Caenorhabditis elegans.
Eggshell chitin and chitin-interacting proteins prevent polyspermy in C. elegans.
Nematode chitin synthases: gene structure, expression and function in Caenorhabditis elegans and the plant parasitic nematode Meloidogyne artiellia.
The chitin synthase genes chs-1 and chs-2 are essential for C. elegans development and responsible for chitin deposition in the eggshell and pharynx, respectively.
Otx/otd homeobox genes specify distinct sensory neuron identities in C. elegans.
Sequence-specific binding to telomeric DNA by CEH-37, a homeodomain protein in the nematode Caenorhabditis elegans.
Intestinal signaling to GABAergic neurons regulates a rhythmic behavior in Caenorhabditis elegans.
A model for Niemann-Pick type C disease in the nematode Caenorhabditis elegans.
Mutations in beta-spectrin disrupt axon outgrowth and sarcomere structure.
Histone H3.3 variant dynamics in the germline of Caenorhabditis elegans.
A 13C isotope labeling strategy reveals the influence of insulin signaling on lipogenesis in C. elegans.
A C. elegans mutant that lives twice as long as wild type.
A Non-Cell-Autonomous Role of BEC-1/BECN1/Beclin1 in Coordinating Cell-Cycle Progression and Stem Cell Proliferation during Germline Development.
A carbon dioxide avoidance behavior is integrated with responses to ambient oxygen and food in Caenorhabditis elegans.
An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans.
Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16.
C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span.
CAMKII and Calcineurin regulate the lifespan of Caenorhabditis elegans through the FOXO transcription factor DAF-16.
Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator.
Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway.
Cell-nonautonomous signaling of FOXO/DAF-16 to the stem cells of Caenorhabditis elegans.
Combined informatic and expression screen identifies the novel DAF-16 target HLH-13.
DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans.
DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans.
DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans.
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.
Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans.
Endogenous cGMP regulates adult longevity via the insulin signaling pathway in Caenorhabditis elegans.
Epidermal Remodeling in Caenorhabditis elegans Dauers Requires the Nidogen Domain Protein DEX-1.
Feeding a ROS-generator to Caenorhabditis elegans leads to increased expression of small heat shock protein HSP-16.2 and hormesis.
Feeding state, insulin and NPR-1 modulate Chemoreceptor gene expression via integration of sensory and circuit inputs.
Histone H3K4me3 modification is a transgenerational epigenetic signal for lipid metabolism in Caenorhabditis elegans.
Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues.
Insulin/IGF-1 signaling regulates proteasome activity through the deubiquitinating enzyme UBH-4.
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16.
Longevity-promoting effects of 4-hydroxy-E-globularinin in Caenorhabditis elegans.
Myoinhibitory peptide signaling modulates aversive gustatory learning in Caenorhabditis elegans.
New genes that extend Caenorhabditis elegans' lifespan in response to reproductive signals.
Normal sleep bouts are not essential for C. elegans survival and FoxO is important for compensatory changes in sleep.
Opposing activities protect against age-onset proteotoxicity.
Quinic acid could be a potential rejuvenating natural compound by improving survival of Caenorhabditis elegans under deleterious conditions.
RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination.
RPN-6 determines C. elegans longevity under proteotoxic stress conditions.
Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway.
Regulation of aging and age-related disease by DAF-16 and heat-shock factor.
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling.
SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans.
Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1.
Stress-response protein expression and DAF-16 translocation were induced in tributyltin-exposed Caenorhabditis elegans.
The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators.
The DAF-16 FOXO transcription factor regulates natc-1 to modulate stress resistance in Caenorhabditis elegans, linking insulin/IGF-1 signaling to protein N-terminal acetylation.
The DAF-16/FOXO transcription factor functions as a regulator of epidermal innate immunity.
The FOXO transcription factor DAF-16 bypasses ire-1 requirement to promote endoplasmic reticulum hoymeostasis.
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans.
The p38 signal transduction pathway participates in the oxidative stress-mediated translocation of DAF-16 to Caenorhabditis elegans nuclei.
The zinc matrix metalloproteinase ZMP-2 increases survival of Caenorhabditis elegans through interference with lipoprotein absorption.
Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans.
Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan.
Transcriptional regulation of Caenorhabditis elegans FOXO/DAF-16 modulates lifespan.
Visible light reduces C. elegans longevity.
daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans.
daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans.
p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans.
Innate immunity mediated longevity and longevity induced by germ cell removal converge on the C-type lectin domain protein IRG-7.
Microtubule plus-end dynamics link wound repair to the innate immune response.
Unusual regulation of a STAT protein by an SLC6 family transporter in C. elegans epidermal innate immunity.
Mitochondrial function is required for secretion of DAF-28/insulin in C. elegans.
C. elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor.
Fertility and germline stem cell maintenance under different diets requires nhr-114/HNF4 in C. elegans.
Proteins interacting with Caenorhabditis elegans Galpha subunits.
Non-centrosomal epidermal microtubules act in parallel to LET-502/ROCK to promote C. elegans elongation.
Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal.
Tyramine functions independently of octopamine in the Caenorhabditis elegans nervous system.
CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans.
egl-17 encodes an invertebrate fibroblast growth factor family member required specifically for sex myoblast migration in Caenorhabditis elegans.
A beta-catenin-dependent Wnt pathway mediates anteroposterior axon guidance in C. elegans motor neurons.
A novel noncanonical Wnt pathway is involved in the regulation of the asymmetric B cell division in C. elegans.
Asymmetric localizations of LIN-17/Fz and MIG-5/Dsh are involved in the asymmetric B cell division in C. elegans.
Dishevelled attenuates the repelling activity of Wnt signaling during neurite outgrowth in Caenorhabditis elegans.
Syndecan defines precise spindle orientation by modulating Wnt signaling in C. elegans.
The N- or C-terminal domains of DSH-2 can activate the C. elegans Wnt/beta-catenin asymmetry pathway.
Unique and redundant beta-catenin regulatory roles of two Dishevelled paralogs during C. elegans asymmetric cell division.
mig-5/Dsh controls cell fate determination and cell migration in C. elegans.
Antagonistic Smad transcription factors control the dauer/non-dauer switch in C. elegans.
Linking the environment, DAF-7/TGFbeta signaling and LAG-2/DSL ligand expression in the germline stem cell niche.
The DAF-3 Smad binds DNA and represses gene expression in the Caenorhabditis elegans pharynx.
The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway.
Trans and cis factors affecting A-to-I RNA editing efficiency of a noncoding editing target in C. elegans.
Caenorhabditis elegans BAF-1 and its kinase VRK-1 participate directly in post-mitotic nuclear envelope assembly.
Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis.
Genome-wide analysis of germ cell proliferation in C.elegans identifies VRK-1 as a key regulator of CEP-1/p53.
Protein kinase VRK-1 regulates cell invasion and EGL-17/FGF signaling in Caenorhabditis elegans.
A ONECUT homeodomain protein communicates X chromosome dose to specify Caenorhabditis elegans sexual fate by repressing a sex switch gene.
CELF family RNA-binding protein UNC-75 regulates two sets of mutually exclusive exons of the unc-32 gene in neuron-specific manners in Caenorhabditis elegans.
Dose-dependent action of the RNA binding protein FOX-1 to relay X-chromosome number and determine C. elegans sex.
Genetic and molecular analysis of fox-1, a numerator element involved in Caenorhabditis elegans primary sex determination.
Identification of a candidate primary sex determination locus, fox-1, on the X chromosome of Caenorhabditis elegans.
Molecular antagonism between X-chromosome and autosome signals determines nematode sex.
The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo.
The T-box transcription factor SEA-1 is an autosomal element of the X:A signal that determines C. elegans sex.
The ortholog of human ataxin-2 is essential for early embryonic patterning in C. elegans.
The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans.
Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivo.
X-chromosome-counting mechanisms that determine nematode sex.
Basolateral endocytic recycling requires RAB-10 and AMPH-1 mediated recruitment of RAB-5 GAP TBC-2 to endosomes.
EHBP-1 functions with RAB-10 during endocytic recycling in Caenorhabditis elegans.
RAB-10 is required for endocytic recycling in the Caenorhabditis elegans intestine.
RAB-10 regulates dendritic branching by balancing dendritic transport.
RAB-10 regulates glutamate receptor recycling in a cholesterol-dependent endocytosis pathway.
RAB-10-GTPase-mediated regulation of endosomal phosphatidylinositol-4,5-bisphosphate.
RAB-10-dependent membrane transport is required for dendrite arborization.
RAB-5 and RAB-10 cooperate to regulate neuropeptide release in Caenorhabditis elegans.
SEC-10 and RAB-10 coordinate basolateral recycling of clathrin-independent cargo through endosomal tubules in Caenorhabditis elegans.
The C. elegans Rab family: Identification, classification and toolkit construction.
Multiple transcription factors directly regulate Hox gene lin-39 expression in ventral hypodermal cells of the C. elegans embryo and larva, including the hypodermal fate regulators LIN-26 and ELT-6.
A casein kinase 1 and PAR proteins regulate asymmetry of a PIP(2) synthesis enzyme for asymmetric spindle positioning.
Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos.
Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans.
C. elegans PAR-3 and PAR-6 are required for apicobasal asymmetries associated with cell adhesion and gastrulation.
LET-99 opposes Galpha/GPR signaling to generate asymmetry for spindle positioning in response to PAR and MES-1/SRC-1 signaling.
PAR-3 is required for epithelial cell polarity in the distal spermatheca of C. elegans.
PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos.
par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3.
SRP-2 is a cross-class inhibitor that participates in postembryonic development of the nematode Caenorhabditis elegans: initial characterization of the clade L serpins.
Mutations in the alpha1 subunit of an L-type voltage-activated Ca2+ channel cause myotonia in Caenorhabditis elegans.
Distinct roles of the Src family kinases, SRC-1 and KIN-22, that are negatively regulated by CSK-1 in C. elegans.
Engulfment of apoptotic cells in C. elegans is mediated by integrin alpha/SRC signaling.
Non-receptor tyrosine kinase CSK-1 controls pharyngeal muscle organization in Caenorhabditis elegans.
SRC-1 and Wnt signaling act together to specify endoderm and to control cleavage orientation in early C. elegans embryos.
SRC-1 mediates UNC-5 signaling in Caenorhabditis elegans.
SRC-1, a non-receptor type of protein tyrosine kinase, controls the direction of cell and growth cone migration in C. elegans.
trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans.
Isolation and characterization of four developmentally regulated cathepsin B-like cysteine protease genes from the nematode Caenorhabditis elegans.
The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification.
The RDE-10/RDE-11 complex triggers RNAi-induced mRNA degradation by association with target mRNA in C. elegans.
Neddylation and deneddylation of CUL-3 is required to target MEI-1/katanin for degradation at the meiosis-to-mitosis transition in C. elegans.
Identification and characterization of a family of Caenorhabditis elegans genes that is homologous to the cadmium-responsive gene cdr-1.
C. elegans MRP-5 Exports Vitamin B12 from Mother to Offspring to Support Embryonic Development.
Control of metazoan heme homeostasis by a conserved multidrug resistance protein.
Inter-organ signalling by HRG-7 promotes systemic haem homeostasis.
Cloning and characterization of the C. elegans gas1 homolog: phas-1.
Molecular cloning and expression of human and mouse tyrosylprotein sulfotransferase-2 and a tyrosylprotein sulfotransferase homologue in Caenorhabditis elegans.
RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans.
Wnt signaling and a Hox protein cooperatively regulate psa-3/Meis to determine daughter cell fate after asymmetric cell division in C. elegans.
Characterization of Drosophila and Caenorhabditis elegans NXF-like-factors, putative homologs of mammalian NXF.
Graded proteasome dysfunction in Caenorhabditis elegans activates an adaptive response involving the conserved skn-1 and elt-2 transcription factors and the autophagy-lysosome pathway.
The Caenorhabditis elegans odr-2 gene encodes a novel Ly-6-related protein required for olfaction.
Characterisation of the N'1 isoform of the cyclic AMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegans.
Cloning, characterization, and expression of the gene for the catalytic subunit of cAMP-dependent protein kinase in Caenorhabditis elegans. Identification of highly conserved and unique isoforms generated by alternative splicing.
Expression of multiple isoforms of the cAMP-dependent protein kinase (PK-A) catalytic subunit in the nematode, Caenorhabditis elegans.
N-Myristoylation of the catalytic subunit of cAMP-dependent protein kinase in the free-living nematode Caenorhabditis elegans.
Organization and alternative splicing of the Caenorhabditis elegans cyclic AMP-dependent protein kinase (PK-A) catalytic subunit gene (kin-1).
PKA controls calcium influx into motor neurons during a rhythmic behavior.
SACY-1 DEAD-Box helicase links the somatic control of oocyte meiotic maturation to the sperm-to-oocyte switch and gamete maintenance in Caenorhabditis elegans.
siRNA-mediated knockdown of a splice variant of the PK-A catalytic subunit gene causes adult-onset paralysis in C. elegans.
Existence of four acetylcholinesterase genes in the nematodes Caenorhabditis elegans and Caenorhabditis briggsae.
A histone methylation network regulates transgenerational epigenetic memory in C. elegans.
Caenorhabditis elegans histone methyltransferase MET-2 shields the male X chromosome from checkpoint machinery and mediates meiotic sex chromosome inactivation.
Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in Caenorhabditis elegans.
Differential localization and independent acquisition of the H3K9me2 and H3K9me3 chromatin modifications in the Caenorhabditis elegans adult germ line.
H3K9me2/3 binding of the MBT domain protein LIN-61 is essential for Caenorhabditis elegans vulva development.
Histone H3K9 methylation is dispensable for Caenorhabditis elegans development but suppresses RNA:DNA hybrid-associated repeat instability.
Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery.
The Nrde pathway mediates small-RNA-directed histone H3 lysine 27 trimethylation in Caenorhabditis elegans.
Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development.
Loading of meiotic cohesin by SCC-2 is required for early processing of DSBs and for the DNA damage checkpoint.
Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance.
NIPBL, encoding a homolog of fungal Scc2-type sister chromatid cohesion proteins and fly Nipped-B, is mutated in Cornelia de Lange syndrome.
Dynein-driven retrograde intraflagellar transport is triphasic in C. elegans sensory cilia.
Role of a class DHC1b dynein in retrograde transport of IFT motors and IFT raft particles along cilia, but not dendrites, in chemosensory neurons of living Caenorhabditis elegans.
The molecular identities of the Caenorhabditis elegans intraflagellar transport genes dyf-6, daf-10 and osm-1.
Caenorhabditis elegans contains two distinct acid sphingomyelinases.
Chaperone-interacting TPR proteins in Caenorhabditis elegans.
Regulation of glial size by eicosapentaenoic acid through a novel Golgi apparatus mechanism.
Identification of a family of animal sphingomyelin synthases.
Depletion of the ER chaperone ENPL-1 sensitizes C. elegans to the anticancer drug cisplatin.
Immunoglobulin-domain proteins required for maintenance of ventral nerve cord organization.
The C. elegans L1CAM homologue LAD-2 functions as a coreceptor in MAB-20/Sema2 mediated axon guidance.
IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses.
C. elegans Notch signaling regulates adult chemosensory response and larval molting quiescence.
Caenorhabditis elegans expresses three functional profilins in a tissue-specific manner.
A new family of small, palmitoylated, membrane-associated proteins, characterized by the presence of a cysteine-rich hydrophobic motif.
A novel heme-responsive element mediates transcriptional regulation in Caenorhabditis elegans.
The evolutionary duplication and probable demise of an endodermal GATA factor in Caenorhabditis elegans.
Identification of the hydrophobic glycoproteins of Caenorhabditis elegans.
Autophagy-dependent ribosomal RNA degradation is essential for maintaining nucleotide homeostasis during C. elegans development.
PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation.
The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes.
The Caenorhabditis elegans mucin-like protein OSM-8 negatively regulates osmosensitive physiology via the transmembrane protein PTR-23.
A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons.
Arsenite-induced germline apoptosis through a MAPK-dependent, p53-independent pathway in Caenorhabditis elegans.
Copper-induced germline apoptosis in Caenorhabditis elegans: the independent roles of DNA damage response signaling and the dependent roles of MAPK cascades.
The Nrf2/SKN-1-dependent glutathione S-transferase pi homologue GST-1 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of manganism.
UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport in C. elegans.
jkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegans.
A photoconvertible reporter of the ubiquitin-proteasome system in vivo.
Elimination of paternal mitochondria through the lysosomal degradation pathway in C. elegans.
Proteasomal ubiquitin receptor RPN-10 controls sex determination in Caenorhabditis elegans.
Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans.
C. elegans G protein regulator RGS-3 controls sensitivity to sensory stimuli.
C. elegans dopaminergic D2-like receptors delimit recurrent cholinergic-mediated motor programs during a goal-oriented behavior.
Divergence in enzyme regulation between Caenorhabditis elegans and human tyrosine hydroxylase, the key enzyme in the synthesis of dopamine.
Dopamine and glutamate control area-restricted search behavior in Caenorhabditis elegans.
Dopamine counteracts octopamine signalling in a neural circuit mediating food response in C. elegans.
Dopamine modulates the plasticity of mechanosensory responses in Caenorhabditis elegans.
Maze exploration and learning in C. elegans.
Molecular mechanisms of amphetamine actions in Caenorhabditis elegans.
Patterning of dopaminergic neurotransmitter identity among Caenorhabditis elegans ray sensory neurons by a TGFbeta family signaling pathway and a Hox gene.
Serotonin receptors antagonistically modulate Caenorhabditis elegans longevity.
Regulatory myosin light-chain genes of Caenorhabditis elegans.
A Neurexin-related protein, BAM-2, terminates axonal branches in C. elegans.
Multiple conserved cell adhesion protein interactions mediate neural wiring of a sensory circuit in C. elegans.
A Novel Caenorhabditis Elegans Proteinopathy Model Shows Changes in mRNA Translational Frameshifting During Aging.
Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan.
The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans.
Translational adaptation to heat stress is mediated by RNA 5-methylcytosine in Caenorhabditis elegans.
A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis.
AIR-2: an Aurora/Ipl1-related protein kinase associated with chromosomes and midbody microtubules is required for polar body extrusion and cytokinesis in Caenorhabditis elegans embryos.
C. elegans condensin promotes mitotic chromosome architecture, centromere organization, and sister chromatid segregation during mitosis and meiosis.
CSC-1: a subunit of the Aurora B kinase complex that binds to the survivin-like protein BIR-1 and the incenp-like protein ICP-1.
Condensin and the spindle midzone prevent cytokinesis failure induced by chromatin bridges in C. elegans embryos.
Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans.
LAB-1 antagonizes the Aurora B kinase in C. elegans.
Phosphorylation of ZEN-4/MKLP1 by aurora B regulates completion of cytokinesis.
Stu-7/air-2 is a C. elegans aurora homologue essential for chromosome segregation during embryonic and post-embryonic development.
The C. elegans Tousled-like kinase contributes to chromosome segregation as a substrate and regulator of the Aurora B kinase.
The Caenorhabditis elegans Aurora B kinase AIR-2 phosphorylates and is required for the localization of a BimC kinesin to meiotic and mitotic spindles.
The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo.
The aurora kinase AIR-2 functions in the release of chromosome cohesion in Caenorhabditis elegans meiosis.
The aurora-related kinase AIR-2 recruits ZEN-4/CeMKLP1 to the mitotic spindle at metaphase and is required for cytokinesis.
The survivin-like C. elegans BIR-1 protein acts with the Aurora-like kinase AIR-2 to affect chromosomes and the spindle midzone.
FMRFamide related peptide ligands activate the Caenorhabditis elegans orphan GPCR Y59H11AL.1.
Luqin-like RYamide peptides regulate food-evoked responses in C. elegans.
CACN-1/Cactin interacts genetically with MIG-2 GTPase signaling to control distal tip cell migration in C. elegans.
Trehalose metabolism genes in Caenorhabditis elegans and filarial nematodes.
The C. elegans genome sequencing project: a beginning.
The Caenorhabditis elegans CPI-2a cystatin-like inhibitor has an essential regulatory role during oogenesis and fertilization.
The Caenorhabditis elegans cathepsin Z-like cysteine protease, Ce-CPZ-1, has a multifunctional role during the worms' development.
MINA-1 and WAGO-4 are part of regulatory network coordinating germ cell death and RNAi in C. elegans.
An SCF-like ubiquitin ligase complex that controls presynaptic differentiation.
Behavioral choice between conflicting alternatives is regulated by a receptor guanylyl cyclase, GCY-28, and a receptor tyrosine kinase, SCD-2, in AIA interneurons of Caenorhabditis elegans.
C. elegans anaplastic lymphoma kinase ortholog SCD-2 controls dauer formation by modulating TGF-beta signaling.
Multiple Signaling Pathways Coordinately Regulate Forgetting of Olfactory Adaptation through Control of Sensory Responses in Caenorhabditis elegans.
Suppressors of transforming growth factor-beta pathway mutants in the Caenorhabditis elegans dauer formation pathway.
The alpha and beta subunits of nematode actin capping protein function in yeast.
Calpains mediate integrin attachment complex maintenance of adult muscle in Caenorhabditis elegans.
Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans.
The atypical calpains: evolutionary analyses and roles in Caenorhabditis elegans cellular degeneration.
A pathway for phagosome maturation during engulfment of apoptotic cells.
Ribonuclease-mediated control of body fat.
Control of type-D GABAergic neuron differentiation by C. elegans UNC-30 homeodomain protein.
Convergent Transcriptional Programs Regulate cAMP Levels in C. elegans GABAergic Motor Neurons.
Convergent genetic programs regulate similarities and differences between related motor neuron classes in Caenorhabditis elegans.
Spatiotemporal control of a novel synaptic organizer molecule.
Chemosensory and hyperoxia circuits in C. elegans males influence sperm navigational capacity.
NMR structure of conserved eukaryotic protein ZK652.3 from C. elegans: a ubiquitin-like fold.
Caenorhabditis elegans nucleoporins Nup93 and Nup205 determine the limit of nuclear pore complex size exclusion in vivo.
Nucleoporins NPP-10, NPP-13 and NPP-20 are required for HCP-4 nuclear import to establish correct centromere assembly.
TFG-1 function in protein secretion and oncogenesis.
Selenoprotein T is required for pathogenic bacteria avoidance in Caenorhabditis elegans.
SynMuv genes redundantly inhibit lin-3/EGF expression to prevent inappropriate vulval induction in C. elegans.
lin-8, which antagonizes Caenorhabditis elegans Ras-mediated vulval induction, encodes a novel nuclear protein that interacts with the LIN-35 Rb protein.
Sequential histone-modifying activities determine the robustness of transdifferentiation.
unc-3, a gene required for axonal guidance in Caenorhabditis elegans, encodes a member of the O/E family of transcription factors.
unc-3-dependent repression of specific motor neuron fates in Caenorhabditis elegans.
A regulatory network of T-box genes and the even-skipped homologue vab-7 controls patterning and morphogenesis in C. elegans.
Isolation and characterization of pmk-(1-3): three p38 homologs in Caenorhabditis elegans.
Repression of the heat shock response is a programmed event at the onset of reproduction.
Two novel transmembrane protein tyrosine kinases expressed during Caenorhabditis elegans hypodermal development.
A C. elegans Zona Pellucida domain protein functions via its ZPc domain.
Characterization of the let-653 gene in Caenorhabditis elegans.
Integrity of narrow epithelial tubes in the C. elegans excretory system requires a transient luminal matrix.
A single histone H1 isoform (H1.1) is essential for chromatin silencing and germline development in Caenorhabditis elegans.
Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome.
Structural genomics of Caenorhabditis elegans: crystal structure of calmodulin.
A Tunable Mechanism Determines the Duration of the Transgenerational Small RNA Inheritance in C. elegans.
DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans.
DEPS-1 promotes P-granule assembly and RNA interference in C. elegans germ cells.
Spatiotemporal regulation of liquid-like condensates in epigenetic inheritance.
Loss of KLP-19 polar ejection force causes misorientation and missegregation of holocentric chromosomes.
A link between meiotic prophase progression and crossover control.
Crossing over during Caenorhabditis elegans meiosis requires a conserved MutS-based pathway that is partially dispensable in budding yeast.
Maternal-effect lethal mutations on linkage group II of Caenorhabditis elegans.
Mutant rec-1 eliminates the meiotic pattern of crossing over in Caenorhabditis elegans.
Pro-crossover factors regulate damage-dependent apoptosis in the Caenorhabditis elegans germ line.
An isoform of eIF4E is a component of germ granules and is required for spermatogenesis in C. elegans.
Functional characterization of five eIF4E isoforms in Caenorhabditis elegans.
Interaction of three Caenorhabditis elegans isoforms of translation initiation factor eIF4E with mono- and trimethylated mRNA 5' cap analogues.
Genetic dissection of ion currents underlying all-or-none action potentials in C. elegans body-wall muscle cells.
Mutant analysis of the Shal (Kv4) voltage-gated fast transient K+ channel in Caenorhabditis elegans.
An instructive role for C. elegans E-cadherin in translating cell contact cues into cortical polarity.
Characterization of a promiscuous GTPase-activating protein that has a bcr-related domain from Caenorhabditis elegans.
Polarization of the C. elegans embryo by RhoGAP-mediated exclusion of PAR-6 from cell contacts.
Acyl-CoA Oxidases Fine-Tune the Production of Ascaroside Pheromones with Specific Side Chain Lengths.
Acyl-CoA oxidase complexes control the chemical message produced by Caenorhabditis elegans.
Biosynthetic tailoring of existing ascaroside pheromones alters their biological function in C. elegans.
Contribution of the peroxisomal acox gene to the dynamic balance of daumone production in Caenorhabditis elegans.
Structural characterization of acyl-CoA oxidases reveals a direct link between pheromone biosynthesis and metabolic state in Caenorhabditis elegans.
Conserved tyrosine kinase promotes the import of silencing RNA into Caenorhabditis elegans cells.
A conserved role of Caenorhabditis elegans CDC-48 in ER-associated protein degradation.
A pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans.
CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication.
CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis.
Caenorhabditis elegans p97 controls germline-specific sex determination by controlling the TRA-1 level in a CUL-2-dependent manner.
Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication.
Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.
An alternatively spliced C. elegans ced-4 RNA encodes a novel cell death inhibitor.
C. elegans MAC-1, an essential member of the AAA family of ATPases, can bind CED-4 and prevent cell death.
CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans.
Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4.
Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline.
Genetic control of programmed cell death in the nematode C. elegans.
Interaction and regulation of subcellular localization of CED-4 by CED-9.
Mechanistic insights into CED-4-mediated activation of CED-3.
Programmed cell death mediated by ced-3 and ced-4 protects Caenorhabditis elegans from Salmonella typhimurium-mediated killing.
Regulation of Caenorhabditis elegans p53/CEP-1-dependent germ cell apoptosis by Ras/MAPK signaling.
Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4.
Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans.
Suppression of CED-3-independent apoptosis by mitochondrial betaNAC in Caenorhabditis elegans.
The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death.
The Caenorhabditis elegans sex determination protein FEM-1 is a CED-3 substrate that associates with CED-4 and mediates apoptosis in mammalian cells.
The cell death pathway regulates synapse elimination through cleavage of gelsolin in Caenorhabditis elegans neurons.
The core apoptotic executioner proteins CED-3 and CED-4 promote initiation of neuronal regeneration in Caenorhabditis elegans.
The metal transporter SMF-3/DMT-1 mediates aluminum-induced dopamine neuron degeneration.
Timing of the onset of a developmental cell death is controlled by transcriptional induction of the C. elegans ced-3 caspase-encoding gene.
Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death.
The dyf-3 gene encodes a novel protein required for sensory cilium formation in Caenorhabditis elegans.
Repression of cell-cell fusion by components of the C. elegans vacuolar ATPase complex.
Targets of TGF-beta signaling in Caenorhabditis elegans dauer formation.
A single immunoglobulin-domain protein required for clustering acetylcholine receptors in C. elegans.
Two conserved epigenetic regulators prevent healthy ageing.
Homologous and unique G protein alpha subunits in the nematode Caenorhabditis elegans.
The complete family of genes encoding G proteins of Caenorhabditis elegans.
Maturation and Clearance of Autophagosomes in Neurons Depends on a Specific Cysteine Protease Isoform, ATG-4.2.
A LIM-9 (FHL)/SCPL-1 (SCP) complex interacts with the C-terminal protein kinase regions of UNC-89 (obscurin) in Caenorhabditis elegans muscle.
A novel protein phosphatase is a binding partner for the protein kinase domains of UNC-89 (Obscurin) in Caenorhabditis elegans.
CPNA-1, a copine domain protein, is located at integrin adhesion sites and is required for myofilament stability in Caenorhabditis elegans.
Cloning and developmental expression analysis of ltd-1, the Caenorhabditis elegans homologue of the mouse kyphoscoliosis (ky) gene.
Profiling of the mammalian mitotic spindle proteome reveals an ER protein, OSTD-1, as being necessary for cell division and ER morphology.
Axon regeneration is regulated by Ets-C/EBP transcription complexes generated by activation of the cAMP/Ca2+ signaling pathways.
ETS-4 is a transcriptional regulator of life span in Caenorhabditis elegans.
Differential role of CENP-A in the segregation of holocentric C. elegans chromosomes during meiosis and mitosis.
Separase Cleaves the N-Tail of the CENP-A Related Protein CPAR-1 at the Meiosis I Metaphase-Anaphase Transition in C. elegans.
Identification of critical residues of choline kinase A2 from Caenorhabditis elegans.
Multiple isoforms of choline kinase from Caenorhabditis elegans: cloning, expression, purification, and characterization.
The crystal structure of choline kinase reveals a eukaryotic protein kinase fold.
Eight genes and alternative RNA processing pathways generate an unexpectedly large diversity of cytoplasmic intermediate filament proteins in the nematode Caenorhabditis elegans.
Essential roles for four cytoplasmic intermediate filament proteins in Caenorhabditis elegans development.
In vivo and in vitro evidence that the four essential intermediate filament (IF) proteins A1, A2, A3 and B1 of the nematode Caenorhabditis elegans form an obligate heteropolymeric IF system.
Intermediate filaments are required for C. elegans epidermal elongation.
CLASPs function redundantly to regulate astral microtubules in the C. elegans embryo.
Differential sulfations and epimerization define heparan sulfate specificity in nervous system development.
A Wnt-Frz/Ror-Dsh pathway regulates neurite outgrowth in Caenorhabditis elegans.
A trophic role for Wnt-Ror kinase signaling during developmental pruning in Caenorhabditis elegans.
Autonomous and nonautonomous regulation of Wnt-mediated neuronal polarity by the C. elegans Ror kinase CAM-1.
Complex network of Wnt signaling regulates neuronal migrations during Caenorhabditis elegans development.
Multiple Wnts and frizzled receptors regulate anteriorly directed cell and growth cone migrations in Caenorhabditis elegans.
Multiple Wnts redundantly control polarity orientation in Caenorhabditis elegans epithelial stem cells.
The C. elegans Frizzled CFZ-2 is required for cell migration and interacts with multiple Wnt signaling pathways.
Two wnt genes in Caenorhabditis elegans.
Wnt-Ror signaling to SIA and SIB neurons directs anterior axon guidance and nerve ring placement in C. elegans.
A conserved family of nuclear export receptors mediates the exit of messenger RNA to the cytoplasm.
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.
aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling.
Dynamic chromatin organization during foregut development mediated by the organ selector gene PHA-4/FoxA.
Genomic analysis of immune response against Vibrio cholerae hemolysin in Caenorhabditis elegans.
Establishing a blueprint for CED-3-dependent killing through identification of multiple substrates for this protease.
The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO.
Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans.
NHR-40, a Caenorhabditis elegans supplementary nuclear receptor, regulates embryonic and early larval development.
Proteomic analysis uncovers a metabolic phenotype in C. elegans after nhr-40 reduction of function.
DNA-binding specificity and in vivo targets of Caenorhabditis elegans nuclear factor I.
Lifespan extension and increased pumping rate accompany pharyngeal muscle-specific expression of nfi-1 in C. elegans.
nfi-I affects behavior and life-span in C. elegans but is not essential for DNA replication or survival.
Posterior patterning by the Caenorhabditis elegans even-skipped homolog vab-7.
A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans.
Ca(2+)/Calmodulin-dependent protein kinase cascade in Caenorhabditis elegans. Implication in transcriptional activation.
CaMKI-dependent regulation of sensory gene expression mediates experience-dependent plasticity in the operating range of a thermosensory neuron.
Feeding state-dependent regulation of developmental plasticity via CaMKI and neuroendocrine signaling.
Single-cell memory regulates a neural circuit for sensory behavior.
The CMK-1 CaMKI and the TAX-4 Cyclic nucleotide-gated channel regulate thermosensory neuron gene expression and function in C. elegans.
The CaM kinase CMK-1 mediates a negative feedback mechanism coupling the C. elegans glutamate receptor GLR-1 with its own transcription.
The balance between cytoplasmic and nuclear CaM kinase-1 signaling controls the operating range of noxious heat avoidance.
The signaling pathway of Caenorhabditis elegans mediates chemotaxis response to the attractant 2-heptanone in a Trojan horse-like pathogenesis.
TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans.
Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling.
Cuticle Integrity and Biogenic Amine Synthesis in Caenorhabditis elegans Require the Cofactor Tetrahydrobiopterin (BH4).
Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen.
Arrestin and the multi-PDZ domain-containing protein MPZ-1 interact with phosphatase and tensin homolog (PTEN) and regulate Caenorhabditis elegans longevity.
Caenorhabditus elegans arrestin regulates neural G protein signaling and olfactory adaptation and recovery.
G protein-coupled receptor kinase function is essential for chemosensation in C. elegans.
Molecular and genetic analyses of the Caenorhabditis elegans dpy-2 and dpy-10 collagen genes: a variety of molecular alterations affect organismal morphology.
Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans.
APX-1 can substitute for its homolog LAG-2 to direct cell interactions throughout Caenorhabditis elegans development.
An inductive interaction in 4-cell stage C. elegans embryos involves APX-1 expression in the signalling cell.
Dorsoventral patterning of the C. elegans postembryonic mesoderm requires both LIN-12/Notch and TGFbeta signaling.
Interchangeability of Caenorhabditis elegans DSL proteins and intrinsic signalling activity of their extracellular domains in vivo.
LIN-12/Notch signaling instructs postsynaptic muscle arm development by regulating UNC-40/DCC and MADD-2 in Caenorhabditis elegans.
MSP and GLP-1/Notch signaling coordinately regulate actomyosin-dependent cytoplasmic streaming and oocyte growth in C. elegans.
The DSL ligand APX-1 is required for normal ovulation in C. elegans.
The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C. elegans embryo.
Two maternal genes, apx-1 and pie-1, are required to distinguish the fates of equivalent blastomeres in the early Caenorhabditis elegans embryo.
An "elongated" translation elongation factor Tu for truncated tRNAs in nematode mitochondria.
Atf-6 Regulates Lifespan through ER-Mitochondrial Calcium Homeostasis.
Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau.
Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans.
Protein misfolding induces hypoxic preconditioning via a subset of the unfolded protein response machinery.
miR-124/ATF-6, a novel lifespan extension pathway of Astragalus polysaccharide in Caenorhabditis elegans.
The ArfGEF GBF-1 Is Required for ER Structure, Secretion and Endocytic Transport in C. elegans.
Serine hydroxymethyltransferase is maternally essential in Caenorhabditis elegans.
A genomewide RNAi screen for genes that affect the stability, distribution and function of P granules in Caenorhabditis elegans.
Autophagy regulates ageing in C. elegans.
HIF-1-dependent regulation of lifespan in Caenorhabditis elegans by the acyl-CoA-binding protein MAA-1.
HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans.
SEPA-1 mediates the specific recognition and degradation of P granule components by autophagy in C. elegans.
Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy.
The two C. elegans ATG-16 homologs have partially redundant functions in the basal autophagy pathway.
The Calponin Family Member CHDP-1 Interacts with Rac/CED-10 to Promote Cell Protrusions.
The cell cortex-localized protein CHDP-1 is required for dendritic development and transport in C. elegans neurons.
The EARP complex and its interactor eipr-1 are required for cargo sorting to dense-core vesicles.
The C. elegans methionine aminopeptidase 2 analog map-2 is required for germ cell proliferation.
Lateralized gustatory behavior of C. elegans is controlled by specific receptor-type guanylyl cyclases.
Caenorhabditis elegans contains structural homologs of human prk and plk.
PAR proteins direct asymmetry of the cell cycle regulators Polo-like kinase and Cdc25.
PLK-1 asymmetry contributes to asynchronous cell division of C. elegans embryos.
Pairing centers recruit a Polo-like kinase to orchestrate meiotic chromosome dynamics in C. elegans.
Polo kinases regulate C. elegans embryonic polarity via binding to DYRK2-primed MEX-5 and MEX-6.
SPAT-1/Bora acts with Polo-like kinase 1 to regulate PAR polarity and cell cycle progression.
The polo-like kinase PLK-1 is required for nuclear envelope breakdown and the completion of meiosis in Caenorhabditis elegans.
A neuronal MAP kinase constrains growth of a Caenorhabditis elegans sensory dendrite throughout the life of the organism.
MAPK-15 is a ciliary protein required for PKD-2 localization and male mating behavior in Caenorhabditis elegans.
Primary Cilium Formation and Ciliary Protein Trafficking Is Regulated by the Atypical MAP Kinase MAPK15 in Caenorhabditis elegans and Human Cells.
The Atypical MAP Kinase SWIP-13/ERK8 Regulates Dopamine Transporters through a Rho-Dependent Mechanism.
C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates.
Clustered LAG-1 binding sites in lag-1/CSL are involved in regulating lag-1 expression during lin-12/Notch-dependent cell-fate specification.
Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA.
Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA.
GLP-1 Notch-LAG-1 CSL control of the germline stem cell fate is mediated by transcriptional targets lst-1 and sygl-1.
LAG-3 is a putative transcriptional activator in the C. elegans Notch pathway.
Notch-dependent induction of left/right asymmetry in C. elegans interneurons and motoneurons.
Positive autoregulation of lag-1 in response to LIN-12 activation in cell fate decisions during C. elegans reproductive system development.
RAM-induced allostery facilitates assembly of a notch pathway active transcription complex.
Roles of the RAM and ANK domains in signaling by the C. elegans GLP-1 receptor.
The CSL transcription factor LAG-1 directly represses hlh-6 expression in C. elegans.
lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H).
Anoxia-reoxygenation regulates mitochondrial dynamics through the hypoxia response pathway, SKN-1/Nrf, and stomatin-like protein STL-1/SLP-2.
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
C. elegans SWAN-1 Binds to EGL-9 and regulates HIF-1-mediated resistance to the bacterial pathogen Pseudomonas aeruginosa PAO1.
CYSL-1 interacts with the O2-sensing hydroxylase EGL-9 to promote H2S-modulated hypoxia-induced behavioral plasticity in C. elegans.
EGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways.
Egg-laying defective mutants of the nematode Caenorhabditis elegans.
HIF-1 is required for heat acclimation in the nematode Caenorhabditis elegans.
Hypoxia and the HIF-1 transcriptional pathway reorganize a neuronal circuit for oxygen-dependent behavior in Caenorhabditis elegans.
Hypoxia and the hypoxic response pathway protect against pore-forming toxins in C. elegans.
Hypoxia regulates glutamate receptor trafficking through an HIF-independent mechanism.
Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegans.
Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa.
Paralysis and killing of Caenorhabditis elegans by enteropathogenic Escherichia coli requires the bacterial tryptophanase gene.
Proteasomal regulation of the hypoxic response modulates aging in C. elegans.
Pseudomonas aeruginosa PAO1 kills Caenorhabditis elegans by cyanide poisoning.
Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans.
Two distinct roles for EGL-9 in the regulation of HIF-1-mediated gene expression in Caenorhabditis elegans.
Protruding vulva mutants identify novel loci and Wnt signaling factors that function during Caenorhabditis elegans vulva development.
The Caenorhabditis elegans gene lin-26 is required to specify the fates of hypodermal cells and encodes a presumptive zinc-finger transcription factor.
The meiotic phosphatase GSP-2/PP1 promotes germline immortality and small RNA-mediated genome silencing.
lir-2, lir-1 and lin-26 encode a new class of zinc-finger proteins and are organized in two overlapping operons both in Caenorhabditis elegans and in Caenorhabditis briggsae.
Transgenerational transmission of environmental information in C. elegans.
Analysis of the NK2 homeobox gene ceh-24 reveals sublateral motor neuron control of left-right turning during sleep.
Muscle and nerve-specific regulation of a novel NK-2 class homeodomain factor in Caenorhabditis elegans.
HRPK-1, a conserved KH-domain protein, modulates microRNA activity during Caenorhabditis elegans development.
Systematic, RNA-interference-mediated identification of mus-101 modifier genes in Caenorhabditis elegans.
CPEB proteins control two key steps in spermatogenesis in C. elegans.
H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage.
Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage.
Conserved binding of GCAC motifs by MEC-8, couch potato, and the RBPMS protein family.
The mec-8 gene of C. elegans encodes a protein with two RNA recognition motifs and regulates alternative splicing of unc-52 transcripts.
Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis.
Galphao/i and Galphas signaling function in parallel with the MSP/Eph receptor to control meiotic diapause in C. elegans.
STAM and Hrs down-regulate ciliary TRP receptors.
C. elegans BLOC-1 Functions in Trafficking to Lysosome-Related Gut Granules.
Methylation of the sterol nucleus by STRM-1 regulates dauer larva formation in Caenorhabditis elegans.
The RGM protein DRAG-1 positively regulates a BMP-like signaling pathway in Caenorhabditis elegans.
The neogenin/DCC homolog UNC-40 promotes BMP signaling via the RGM protein DRAG-1 in C. elegans.
The C. elegans vulval induction gene lin-2 encodes a member of the MAGUK family of cell junction proteins.
FACT complex gene duplicates exhibit redundant and non-redundant functions in C. elegans.
A nuclear lamin protein of the nematode Caenorhabditis elegans with unusual structural features: cDNA cloning and gene organization.
C. elegans nuclear envelope proteins emerin, MAN1, lamin, and nucleoporins reveal unique timing of nuclear envelope breakdown during mitosis.
Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexes.
Fate of the nuclear lamina during Caenorhabditis elegans apoptosis.
Lamin-dependent localization of UNC-84, a protein required for nuclear migration in Caenorhabditis elegans.
MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans.
MEL-28, a novel nuclear-envelope and kinetochore protein essential for zygotic nuclear-envelope assembly in C. elegans.
The Caenorhabditis elegans SUN protein UNC-84 interacts with lamin to transfer forces from the cytoplasm to the nucleoskeleton during nuclear migration.
The expression, lamin-dependent localization and RNAi depletion phenotype for emerin in C. elegans.
Transmission electron microscope studies of the nuclear envelope in Caenorhabditis elegans embryos.
Expression of the CCAAT-binding factor NF-Y in Caenorhabditis elegans.
The NF-Y complex negatively regulates Caenorhabditis elegans tbx-2 expression.
Transcription factor NFY globally represses the expression of the C. elegans Hox gene Abdominal-B homolog egl-5.
Disruption of Caenorhabditis elegans muscle structure and function caused by mutation of troponin I.
Tissue expression of four troponin I genes and their molecular interactions with two troponin C isoforms in Caenorhabditis elegans.
Cloning and analysis of cDNA sequences coding for two 16 kilodalton heat shock proteins (hsps) in Caenorhabditis elegans: homology with the small hsps of Drosophila.
Locus encoding a family of small heat shock genes in Caenorhabditis elegans: two genes duplicated to form a 3.8-kilobase inverted repeat.
A novel H(+)-coupled oligopeptide transporter (OPT3) from Caenorhabditis elegans with a predominant function as a H(+) channel and an exclusive expression in neurons.
Evolution of dnmt-2 and mbd-2-like genes in the free-living nematodes Pristionchus pacificus, Caenorhabditis elegans and Caenorhabditis briggsae.
Behavioral motifs and neural pathways coordinating O2 responses and aggregation in C. elegans.
Odorant-selective genes and neurons mediate olfaction in C. elegans.
The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions.
beta-Integrin de-phosphorylation by the density-enhanced phosphatase DEP-1 attenuates EGFR signaling in C. elegans.
C. elegans SUR-6/PR55 cooperates with LET-92/protein phosphatase 2A and promotes Raf activity independently of inhibitory Akt phosphorylation sites.
C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation.
Caenorhabditis elegans lin-45 raf is essential for larval viability, fertility and the induction of vulval cell fates.
Cation diffusion facilitator proteins modulate Raf-1 activity.
The ERK MAP kinase cascade mediates tail swelling and a protective response to rectal infection in C. elegans.
The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans.
The germinal center kinase GCK-1 is a negative regulator of MAP kinase activation and apoptosis in the C. elegans germline.
Translation repression by GLD-1 protects its mRNA targets from nonsense-mediated mRNA decay in C. elegans.
Computational and molecular characterization of multiple isoforms of lfe-2 gene in nematode C. elegans.
Filamin and phospholipase C-epsilon are required for calcium signaling in the Caenorhabditis elegans spermatheca.
Inositol trisphosphate mediates a RAS-independent response to LET-23 receptor tyrosine kinase activation in C. elegans.
Oscillatory Ca2+ signaling in the isolated Caenorhabditis elegans intestine: role of the inositol-1,4,5-trisphosphate receptor and phospholipases C beta and gamma.
M142.2 (cut-6), a novel Caenorhabditis elegans matrix gene important for dauer body shape.
Distinct requirements for somatic and germline expression of a generally expressed Caernorhabditis elegans gene.
Telomeric position effect variegation in Saccharomyces cerevisiae by Caenorhabditis elegans linker histones suggests a mechanistic connection between germ line and telomeric silencing.
The Caenorhabditis elegans genes sqv-2 and sqv-6, which are required for vulval morphogenesis, encode glycosaminoglycan galactosyltransferase II and xylosyltransferase.
Rabphilin potentiates soluble N-ethylmaleimide sensitive factor attachment protein receptor function independently of rab3.
Global transcriptional regulation of innate immunity by ATF-7 in C. elegans.
Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species.
Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans.
RFX transcription factor DAF-19 regulates 5-HT and innate immune responses to pathogenic bacteria in Caenorhabditis elegans.
The developmental intestinal regulator ELT-2 controls p38-dependent immune responses in adult C. elegans.
Expression of three Caenorhabditis elegans N-acetylglucosaminyltransferase I genes during development.
A reverse genetic analysis of components of the Toll signaling pathway in Caenorhabditis elegans.
Caenorhabditis elegans cog-1 locus encodes GTX/Nkx6.1 homeodomain proteins and regulates multiple aspects of reproductive system development.
Two functionally distinct axin-like proteins regulate canonical Wnt signaling in C. elegans.
A Genetic Cascade of let-7-ncl-1-fib-1 Modulates Nucleolar Size and rRNA Pool in Caenorhabditis elegans.
Nucleologenesis in the Caenorhabditis elegans embryo.
A role for separase in the regulation of RAB-11-positive vesicles at the cleavage furrow and midbody.
GCNA Interacts with Spartan and Topoisomerase II to Regulate Genome Stability.
Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons.
The demethylase NMAD-1 regulates DNA replication and repair in the Caenorhabditis elegans germline.
Zygotic genome activation triggers chromosome damage and checkpoint signaling in C. elegans primordial germ cells.
A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span.
Caenorhabditis elegans dosage compensation regulates histone H4 chromatin state on X chromosomes.
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans.
Loss of PGL-1 and PGL-3, members of a family of constitutive germ-granule components, promotes germline apoptosis in C. elegans.
Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO.
Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1.
Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.
Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide.
Scavengers of reactive gamma-ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein-level interactions with SIR-2.1 and ETS-7.
Somatically expressed germ-granule components, PGL-1 and PGL-3, repress programmed cell death in C. elegans.
Developmental defects observed in hypomorphic anaphase-promoting complex mutants are linked to cell cycle abnormalities.
The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo.
Extracellular leucine-rich repeat proteins are required to organize the apical extracellular matrix and maintain epithelial junction integrity in C. elegans.
Lysine methylation of VCP by a member of a novel human protein methyltransferase family.
Acquisition of triacylglycerol transfer activity by microsomal triglyceride transfer protein during evolution.
Redox regulation of germline and vulval development in Caenorhabditis elegans.
Regulation of lipoprotein assembly, secretion and fatty acid beta-oxidation by Krueppel-like transcription factor, klf-3.
PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis.
Molecular characterization in the dpy-14 region identifies the adenosylhomocysteine hydrolase gene in Caenorhabditis elegans.
Multiple doublesex-related genes specify critical cell fates in a C. elegans male neural circuit.
Regulation of sex-specific differentiation and mating behavior in C. elegans by a new member of the DM domain transcription factor family.
A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage.
Endocytosis and intracellular trafficking contribute to necrotic neurodegeneration in C. elegans.
Multiple genes for vacuolar-type ATPase proteolipids in Caenorhabditis elegans: a new gene, vha-3, has a distinct cell-specific distribution.
Three vha genes encode proteolipids of Caenorhabditis elegans vacuolar-type ATPase. Gene structures and preferential expression in an H-shaped excretory cell and rectal cells.
Adaptive and specialised transcriptional responses to xenobiotic stress in Caenorhabditis elegans are regulated by nuclear hormone receptors.
NHR-176 regulates cyp-35d1 to control hydroxylation-dependent metabolism of thiabendazole in Caenorhabditis elegans.
OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans.
Glycosyl phosphatidylinositol anchor biosynthesis is essential for maintaining epithelial integrity during Caenorhabditis elegans embryogenesis.
The nuclear receptor superfamily has undergone extensive proliferation and diversification in nematodes.
Beta-catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions.
Intracellular phospholipase A1 and acyltransferase, which are involved in Caenorhabditis elegans stem cell divisions, determine the sn-1 fatty acyl chain of phosphatidylinositol.
Roles of acidic phospholipids and nucleotides in regulating membrane binding and activity of a calcium-independent phospholipase A2 isoform.
Caenorhabditis elegans levamisole resistance genes lev-1, unc-29, and unc-38 encode functional nicotinic acetylcholine receptor subunits.
Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans.
C. elegans AP-2 and retromer control Wnt signaling by regulating mig-14/Wntless.
The Caenorhabditis elegans Tubby homolog dynamically modulates olfactory cilia membrane morphogenesis and phospholipid composition.
Wnt signaling requires retromer-dependent recycling of MIG-14/Wntless in Wnt-producing cells.
unc-101, a gene required for many aspects of Caenorhabditis elegans development and behavior, encodes a clathrin-associated protein.
Caenorhabditis elegans OSR-1 regulates behavioral and physiological responses to hyperosmotic environments.
A molecular link between gene-specific and chromosome-wide transcriptional repression.
An SMC-like protein binds and regulates Caenorhabditis elegans condensins.
Condensin restructures chromosomes in preparation for meiotic divisions.
Condensins regulate meiotic DNA break distribution, thus crossover frequency, by controlling chromosome structure.
DPY-26, a link between dosage compensation and meiotic chromosome segregation in the nematode.
Genes that implement the hermaphrodite mode of dosage compensation in Caenorhabditis elegans.
MIX-1: an essential component of the C. elegans mitotic machinery executes X chromosome dosage compensation.
Meiotic crossover number and distribution are regulated by a dosage compensation protein that resembles a condensin subunit.
Sex-specific assembly of a dosage compensation complex on the nematode X chromosome.
Three distinct condensin complexes control C. elegans chromosome dynamics.
Cortical granule exocytosis in C. elegans is regulated by cell cycle components including separase.
Inducible antibacterial defense system in C. elegans.
Protist-type lysozymes of the nematode Caenorhabditis elegans contribute to resistance against pathogenic Bacillus thuringiensis.
RNAi screen of DAF-16/FOXO target genes in C. elegans links pathogenesis and dauer formation.
GLH-1, the C. elegans P granule protein, is controlled by the JNK KGB-1 and by the COP9 subunit CSN-5.
Germ-granule components prevent somatic development in the C. elegans germline.
Multiple potential germ-line helicases are components of the germ-line-specific P granules of Caenorhabditis elegans.
PAN-1, a P-granule component important for C. elegans fertility, has dual roles in the germline and soma.
PGL proteins self associate and bind RNPs to mediate germ granule assembly in C. elegans.
The GLH proteins, Caenorhabditis elegans P granule components, associate with CSN-5 and KGB-1, proteins necessary for fertility, and with ZYX-1, a predicted cytoskeletal protein.
glh-1, a germ-line putative RNA helicase from Caenorhabditis, has four zinc fingers.
The Caenorhabditis elegans gene CeAPN1 encodes a homolog of Escherichia coli and yeast apurinic/apyrimidinic endonuclease.
Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans.
cDNA cloning and expression of a family of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase sequence homologs from Caenorhabditis elegans.
C. elegans ankyrin repeat protein VAB-19 is a component of epidermal attachment structures and is essential for epidermal morphogenesis.
Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain.
epg-1 functions in autophagy-regulated processes and may encode a highly divergent Atg13 homolog in C. elegans.
Identification of an RNA polymerase III regulator linked to disease-associated protein aggregation.
Shared gene expression in distinct neurons expressing common selector genes.
Identification, sequence, and expression of an invertebrate caveolin gene family from the nematode Caenorhabditis elegans. Implications for the molecular evolution of mammalian caveolin genes.
Control of rapsyn stability by the CUL-3-containing E3 ligase complex.
KEL-8 is a substrate receptor for CUL3-dependent ubiquitin ligase that regulates synaptic glutamate receptor turnover.
REF-1, a protein with two bHLH domains, alters the pattern of cell fusion in C. elegans by regulating Hox protein activity.
Regulation of neuronal lineage decisions by the HES-related bHLH protein REF-1.
The REF-1 family of bHLH transcription factors pattern C. elegans embryos through Notch-dependent and Notch-independent pathways.
Characterization of Caenorhabditis elegans homologs of the Down syndrome candidate gene DYRK1A.
A unified nomenclature for TATA box binding protein (TBP)-associated factors (TAFs) involved in RNA polymerase II transcription.
Distinct requirements for C.elegans TAF(II)s in early embryonic transcription.
Boundary cells restrict dystroglycan trafficking to control basement membrane sliding during tissue remodeling.
Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE.
Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene.
Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo.
Notch signalling is required for both dauer maintenance and recovery in C. elegans.
The CHORD protein CHP-1 regulates EGF receptor trafficking and signaling in C. elegans and in human cells.
The Caenorhabditis elegans lin-12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch.
lin-12, a nematode homeotic gene, is homologous to a set of mammalian proteins that includes epidermal growth factor.
sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins.
O-GlcNAc reports ambient temperature and confers heat resistance on ectotherm development.
O-linked GlcNAc transferase is a conserved nucleocytoplasmic protein containing tetratricopeptide repeats.
Identification of mutations that delay somatic or reproductive aging of Caenorhabditis elegans.
Lifespan extension in C. elegans caused by bacterial colonization of the intestine and subsequent activation of an innate immune response.
The genetics of feeding in Caenorhabditis elegans.
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol.
Genetic analysis of endocytosis in Caenorhabditis elegans: coelomocyte uptake defective mutants.
The Caenorhabditis elegans gene lin-10 is broadly expressed while required specifically for the determination of vulval cell fates.
Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.
Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.
The general control nonderepressible-2 kinase mediates stress response and longevity induced by target of rapamycin inactivation in Caenorhabditis elegans.
GLC-3: a novel fipronil and BIDN-sensitive, but picrotoxinin-insensitive, L-glutamate-gated chloride channel subunit from Caenorhabditis elegans.
Cloning and functional characterization of a folate transporter from the nematode Caenorhabditis elegans.
Innexin-3 forms connexin-like intercellular channels.
NLR-1/CASPR Anchors F-Actin to Promote Gap Junction Formation.
eat-5 and unc-7 represent a multigene family in Caenorhabditis elegans involved in cell-cell coupling.
Characterization of four new tcp-1-related cct genes from the nematode Caenorhabditis elegans.
TetraThymosinbeta is required for actin dynamics in Caenorhabditis elegans and acts via functionally different actin-binding repeats.
GEI-8, a homologue of vertebrate nuclear receptor corepressor NCoR/SMRT, regulates gonad development and neuronal functions in Caenorhabditis elegans.
Isolation of the interacting molecules with GEX-3 by a novel functional screening.
NCoR1 is a conserved physiological modulator of muscle mass and oxidative function.
mab-7 encodes a novel transmembrane protein that orchestrates sensory ray morphogenesis in C. elegans.
The pseudokinase NIPI-4 is a novel regulator of antimicrobial peptide gene expression.
A Caenorhabditis elegans cohesion protein with functions in meiotic chromosome pairing and disjunction.
Chromosome cohesion is regulated by a clock gene paralogue TIM-1.
Divergent kleisin subunits of cohesin specify mechanisms to tether and release meiotic chromosomes.
Meiotic HORMA domain proteins prevent untimely centriole disengagement during Caenorhabditis elegans spermatocyte meiosis.
Synapsis-defective mutants reveal a correlation between chromosome conformation and the mode of double-strand break repair during Caenorhabditis elegans meiosis.
The Caenorhabditis elegans SCC-3 homologue is required for meiotic synapsis and for proper chromosome disjunction in mitosis and meiosis.
The axial element protein HTP-3 promotes cohesin loading and meiotic axis assembly in C. elegans to implement the meiotic program of chromosome segregation.
Fertilization-induced K63-linked ubiquitylation mediates clearance of maternal membrane proteins.
Interactions within the ubiquitin pathway of Caenorhabditis elegans.
UEV-1 is an ubiquitin-conjugating enzyme variant that regulates glutamate receptor trafficking in C. elegans neurons.
Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation.
Ubiquitination is involved in secondary growth, not initial formation of polyglutamine protein aggregates in C. elegans.
A transcriptional mediator protein that is required for activation of many RNA polymerase II promoters and is conserved from yeast to humans.
Caenorhabditis elegans mediator complexes are required for developmental-specific transcriptional activation.
Components of the transcriptional Mediator complex are required for asymmetric cell division in C. elegans.
The MED-7 transcriptional mediator encoded by let-49 is required for gonad and germ cell development in Caenorhabditis elegans.
The nematode homologue of Mediator complex subunit 28, F28F8.5, is a critical regulator of C. elegans development.
The Caenorhabditis elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complex.
A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling.
Double bromodomain protein BET-1 and MYST HATs establish and maintain stable cell fates in C. elegans.
A conserved Six-Eya cassette acts downstream of Wnt signaling to direct non-myogenic versus myogenic fates in the C. elegans postembryonic mesoderm.
Caenorhabditis elegans eyes absent ortholog EYA-1 is required for stress resistance.
Lineage context switches the function of a C. elegans Pax6 homolog in determining a neuronal fate.
Six and Eya promote apoptosis through direct transcriptional activation of the proapoptotic BH3-only gene egl-1 in Caenorhabditis elegans.
The C. elegans eyes absent ortholog EYA-1 is required for tissue differentiation and plays partially redundant roles with PAX-6.
The L-type cyclin CYL-1 and the heat-shock-factor HSF-1 are required for heat-shock-induced protein expression in Caenorhabditis elegans.
cdc-25.2, a Caenorhabditis elegans ortholog of cdc25, is required for male tail morphogenesis.
A new thermosensitive smc-3 allele reveals involvement of cohesin in homologous recombination in C. elegans.
Distinct developmental function of two Caenorhabditis elegans homologs of the cohesin subunit Scc1/Rad21.
LAB-1 targets PP1 and restricts Aurora B kinase upon entrance into meiosis to promote sister chromatid cohesion.
Cloning and characterization of the NADH pyrophosphatases from Caenorhabditis elegans and Saccharomyces cerevisiae, members of a Nudix hydrolase subfamily.
Disruption of clh-1, a chloride channel gene, results in a wider body of Caenorhabditis elegans.
Caenorhabditis elegans embryos contain only one major species of Ro RNP.
The Caenorhabditis elegans rop-1 gene encodes the homologue of the human 60-kDa Ro autoantigen.
Makorin ortholog LEP-2 regulates LIN-28 stability to promote the juvenile-to-adult transition in Caenorhabditis elegans.
The Long Non-Coding RNA lep-5 Promotes the Juvenile-to-Adult Transition by Destabilizing LIN-28.
The Makorin lep-2 and the lncRNA lep-5 regulate lin-28 to schedule sexual maturation of the C. elegans nervous system.
Multiple Skp1-related proteins in Caenorhabditis elegans: diverse patterns of interaction with Cullins and F-box proteins.
Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex.
cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.
Novel transcription coactivator complex containing activating signal cointegrator 1.
Arginine methylation modulates autophagic degradation of PGL granules in C. elegans.
PGL germ granule assembly protein is a base-specific, single-stranded RNase.
Polar positioning of phase-separated liquid compartments in cells regulated by an mRNA competition mechanism.
Selective autophagic degradation of maternally-loaded germline P granule components in somatic cells during C. elegans embryogenesis.
The PGL family proteins associate with germ granules and function redundantly in Caenorhabditis elegans germline development.
The composition of a protein aggregate modulates the specificity and efficiency of its autophagic degradation.
Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome.
Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport.
Mutations in a guanylate cyclase GCY-35/GCY-36 modify Bardet-Biedl syndrome-associated phenotypes in Caenorhabditis elegans.
Saccharomyces cerevisiae GNA1, an essential gene encoding a novel acetyltransferase involved in UDP-N-acetylglucosamine synthesis.
The terminal phase of cytokinesis in the Caenorhabditis elegans early embryo requires protein glycosylation.
Inactivation of Caenorhabditis elegans aminopeptidase DNPP-1 restores endocytic sorting and recycling in tat-1 mutants.
The bromodomain protein LEX-1 acts with TAM-1 to modulate gene expression in C. elegans.
The Caenorhabditis elegans eukaryotic initiation factor 5A homologue, IFF-1, is required for germ cell proliferation, gametogenesis and localization of the P-granule component PGL-1.
C. elegans RBX-2-CUL-5- and RBX-1-CUL-2-based complexes are redundant for oogenesis and activation of the MAP kinase MPK-1.
A targeted RNAi screen for genes involved in chromosome morphogenesis and nuclear organization in the Caenorhabditis elegans germline.
Antagonistic functions of SET-2/SET1 and HPL/HP1 proteins in C. elegans development.
Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells.
Depletion of a novel SET-domain protein enhances the sterility of mes-3 and mes-4 mutants of Caenorhabditis elegans.
Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans.
Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan.
Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3S HDAC complex in C. elegans.
Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans.
Dcp2 Decaps m2,2,7GpppN-capped RNAs, and its activity is sequence and context dependent.
Diverse functions of mRNA metabolism factors in stress defense and aging of Caenorhabditis elegans.
Large P body-like RNPs form in C. elegans oocytes in response to arrested ovulation, heat shock, osmotic stress, and anoxia and are regulated by the major sperm protein pathway.
The C. elegans mRNA decapping enzyme shapes morphology of cilia.
Ndc1 drives nuclear pore complex assembly independent of membrane biogenesis to promote nuclear formation and growth.
An Sp1 transcription factor coordinates caspase-dependent and -independent apoptotic pathways.
Caenorhabditis elegans PIG-1/MELK acts in a conserved PAR-4/LKB1 polarity pathway to promote asymmetric neuroblast divisions.
Comparative genetic, proteomic and phosphoproteomic analysis of C. elegans embryos with a focus on ham-1/STOX and pig-1/MELK in dopaminergic neuron development.
Developmental stage-dependent transcriptional regulatory pathways control neuroblast lineage progression.
Polarized myosin produces unequal-size daughters during asymmetric cell division.
The C. elegans MELK ortholog PIG-1 regulates cell size asymmetry and daughter cell fate in asymmetric neuroblast divisions.
Aberrant fat metabolism in Caenorhabditis elegans mutants with defects in the defecation motor program.
Genetic analysis of defecation in Caenorhabditis elegans.
Regulation of retrograde signaling at neuromuscular junctions by the novel C2 domain protein AEX-1.
The non-neuronal syntaxin SYN-1 regulates defecation behavior and neural activity in C. elegans through interaction with the Munc13-like protein AEX-1.
Differential expression pattern of the four mitochondrial adenine nucleotide transporter ant genes and their roles during the development of Caenorhabditis elegans.
CDC-25.2, a C. elegans ortholog of cdc25, is essential for the progression of intestinal divisions.
Cell cycle control by daf-21/Hsp90 at the first meiotic prophase/metaphase boundary during oogenesis in Caenorhabditis elegans.
Dominant mutations in the Caenorhabditis elegans Myt1 ortholog wee-1.3 reveal a novel domain that controls M-phase entry during spermatogenesis.
The C. elegans DYRK Kinase MBK-2 marks oocyte proteins for degradation in response to meiotic maturation.
The C. elegans Myt1 ortholog is required for the proper timing of oocyte maturation.
Two zinc finger proteins, OMA-1 and OMA-2, are redundantly required for oocyte maturation in C. elegans.
Promoters recognized by forkhead proteins exist for individual 21U-RNAs.
The forkhead gene family of Caenorhabditis elegans.
A Caenorhabditis elegans Zinc Finger Transcription Factor, ztf-6, Required for the Specification of a Dopamine Neuron-Producing Lineage.
The C. elegans gene pme-5: molecular cloning and role in the DNA-damage response of a tankyrase orthologue.
The DNA damage-inducible C. elegans tankyrase is a nuclear protein closely linked to chromosomes.
The C. elegans apoptotic nuclease NUC-1 is related in sequence and activity to mammalian DNase II.
Mutagenic and chemical modification of the ABA-1 allergen of the nematode Ascaris: consequences for structure and lipid binding properties.
Sequence-divergent units of the ABA-1 polyprotein array of the nematode Ascaris suum have similar fatty-acid- and retinol-binding properties but different binding-site environments.
The ABA-1 allergen of the parasitic nematode Ascaris suum: fatty acid and retinoid binding function and structural characterization.
The DvA-1 polyprotein of the parasitic nematode Dictyocaulus viviparus. A small helix-rich lipid-binding protein.
The gp15/400 polyprotein antigen of Brugia malayi binds fatty acids and retinoids.
The NEMP family supports metazoan fertility and nuclear envelope stiffness.
Nicotinic acetylcholine receptors in the nematode Caenorhabditis elegans.
PKC-1 regulates secretion of neuropeptides.
The Ror receptor tyrosine kinase CAM-1 is required for ACR-16-mediated synaptic transmission at the C. elegans neuromuscular junction.
acr-16 encodes an essential subunit of the levamisole-resistant nicotinic receptor at the Caenorhabditis elegans neuromuscular junction.
A regulatory cytoplasmic poly(A) polymerase in Caenorhabditis elegans.
Four KH domains of the C. elegans Bicaudal-C ortholog GLD-3 form a globular structural platform.
GLD-3 and control of the mitosis/meiosis decision in the germline of Caenorhabditis elegans.
GLD-3, a bicaudal-C homolog that inhibits FBF to control germline sex determination in C. elegans.
GLS-1, a novel P granule component, modulates a network of conserved RNA regulators to influence germ cell fate decisions.
POS-1 Promotes Endo-mesoderm Development by Inhibiting the Cytoplasmic Polyadenylation of neg-1 mRNA.
Role of C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry.
Odd-skipped homologs function during gut development in C. elegans.
An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans.
C. elegans GATA factors EGL-18 and ELT-6 function downstream of Wnt signaling to maintain the progenitor fate during larval asymmetric divisions of the seam cells.
Cell fates and fusion in the C. elegans vulval primordium are regulated by the EGL-18 and ELT-6 GATA factors -- apparent direct targets of the LIN-39 Hox protein.
ELT-5 and ELT-6 are required continuously to regulate epidermal seam cell differentiation and cell fusion in C. elegans.
The nT1 translocation separates vulval regulatory elements from the egl-18 and elt-6 GATA factor genes.
Twitchin kinase interacts with MAPKAP kinase 2 in Caenorhabditis elegans striated muscle.
Using RNA interference to identify specific modifiers of a temperature-sensitive, embryonic-lethal mutation in the Caenorhabditis elegans ubiquitin-like Nedd8 protein modification pathway E1-activating gene rfl-1.
eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans.
NRAP-1 Is a Presynaptically Released NMDA Receptor Auxiliary Protein that Modifies Synaptic Strength.
Evolutionary conservation of redundancy between a diverged pair of forkhead transcription factor homologues.
AFF-1, a FOS-1-regulated fusogen, mediates fusion of the anchor cell in C. elegans.
Glia delimit shape changes of sensory neuron receptive endings in C. elegans.
A ZTF-7/RPS-2 complex mediates the cold-warm response in C. elegans.
DPY-17 and MUA-3 interact for connective tissue-like tissue integrity in Caenorhabditis elegans: A model for Marfan Syndrome.
MUP-4 is a novel transmembrane protein with functions in epithelial cell adhesion in Caenorhabditis elegans.
mua-3, a gene required for mechanical tissue integrity in Caenorhabditis elegans, encodes a novel transmembrane protein of epithelial attachment complexes.
ARK-1 inhibits EGFR signaling in C. elegans.
Hemicentin, a conserved extracellular member of the immunoglobulin superfamily, organizes epithelial and other cell attachments into oriented line-shaped junctions.
An essential role for XBP-1 in host protection against immune activation in C. elegans.
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development.
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA.
Neuronal XBP-1 Activates Intestinal Lysosomes to Improve Proteostasis in C. elegans.
Physiological IRE-1-XBP-1 and PEK-1 signaling in Caenorhabditis elegans larval development and immunity.
Sumoylation regulates ER stress response by modulating calreticulin gene expression in XBP-1-dependent mode in Caenorhabditis elegans.
XBP-1 Remodels Lipid Metabolism to Extend Longevity.
XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity.
Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis.
Genes required for osmoregulation and apical secretion in Caenorhabditis elegans.
The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans.
RNAi analysis of genes expressed in the ovary of Caenorhabditis elegans.
Hox and a newly identified E2F co-repress cell death in Caenorhabditis elegans.
Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis.
Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation.
Cloning of three Caenorhabditis elegans genes potentially encoding novel matrix metalloproteinases.
Role of matrix metalloproteinase ZMP-2 in pathogen resistance and development in Caenorhabditis elegans.
Identification of the C. elegans anaphase promoting complex subunit Cdc26 by phenotypic profiling and functional rescue in yeast.
Thymidylate synthase and dihydropyrimidine dehydrogenase levels are associated with response to 5-fluorouracil in Caenorhabditis elegans.
The egg surface LDL receptor repeat-containing proteins EGG-1 and EGG-2 are required for fertilization in Caenorhabditis elegans.
Protons act as a transmitter for muscle contraction in C. elegans.
CeHMT-1, a putative phytochelatin transporter, is required for cadmium tolerance in Caenorhabditis elegans.
The human ABCB6 protein is the functional homologue of HMT-1 proteins mediating cadmium detoxification.
Analysis of osm-6, a gene that affects sensory cilium structure and sensory neuron function in Caenorhabditis elegans.
A C. elegans Myc-like network cooperates with semaphorin and Wnt signaling pathways to control cell migration.
Microsporidia Intracellular Development Relies on Myc Interaction Network Transcription Factors in the Host.
Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals.
The Caenorhabditis elegans Myc-Mondo/Mad complexes integrate diverse longevity signals.
WBSCR14, a gene mapping to the Williams-Beuren syndrome deleted region, is a new member of the Mlx transcription factor network.
A Caenorhabditis elegans insulin-like peptide, INS-17: its physiological function and expression pattern.
Cloning and characterization of a Caenorhabditis elegans cDNA encoding a new insulin/IGF-like peptide.
Extension of the mitochondrial transporter super-family: sequences of five members from the nematode worm, Caenorhabditis elegans.
The sequence, bacterial expression, and functional reconstitution of the rat mitochondrial dicarboxylate transporter cloned via distant homologs in yeast and Caenorhabditis elegans.
Functional coordination of intraflagellar transport motors.
Functional genomics of the cilium, a sensory organelle.
The zebrafish fleer gene encodes an essential regulator of cilia tubulin polyglutamylation.
Calcineurin regulates enteric muscle contraction through EXP-1, excitatory GABA-gated channel, in C. elegans.
EXP-1 is an excitatory GABA-gated cation channel.
Specification of muscle neurotransmitter sensitivity by a Paired-like homeodomain protein in Caenorhabditis elegans.
The Caenorhabditis elegans unc-49 locus encodes multiple subunits of a heteromultimeric GABA receptor.
Caenorhabditis elegans protein arginine methyltransferase PRMT-5 negatively regulates DNA damage-induced apoptosis.
A conserved RNA-protein complex component involved in physiological germline apoptosis regulation in C. elegans.
Translational control of the oogenic program by components of OMA ribonucleoprotein particles in Caenorhabditis elegans.
cgh-1, a conserved predicted RNA helicase required for gametogenesis and protection from physiological germline apoptosis in C. elegans.
ifet-1 is a broad-scale translational repressor required for normal P granule formation in C. elegans.
Regulation of C. elegans L4 cuticle collagen genes by the heterochronic protein LIN-29.
Characterization of a G-protein alpha-subunit gene from the nematode Caenorhabditis elegans.
Chemosensation of bacterial secondary metabolites modulates neuroendocrine signaling and behavior of C. elegans.
Characterization of metallothionein cDNAs induced by cadmium in the nematode Caenorhabditis elegans.
Metallothionein genes in the nematode Caenorhabditis elegans and metal inducibility in mammalian culture cells.
Purification, characterization, and cDNA cloning of a novel metallothionein-like, cadmium-binding protein from Caenorhabditis elegans.
The novel metallothionein genes of Caenorhabditis elegans. Structural organization and inducible, cell-specific expression.
Caenorhabditis elegans decapping proteins: localization and functional analysis of Dcp1, Dcp2, and DcpS during embryogenesis.
A homozygous missense mutation in ERAL1, encoding a mitochondrial rRNA chaperone, causes Perrault syndrome.
Dosage compensation proteins targeted to X chromosomes by a determinant of hermaphrodite fate.
Genome-wide screening identifies new genes required for stress-induced phase 2 detoxification gene expression in animals.
Recruitment of C. elegans dosage compensation proteins for gene-specific versus chromosome-wide repression.
SDC-3 coordinates the assembly of a dosage compensation complex on the nematode X chromosome.
The Caenorhabditis elegans gene sdc-2 controls sex determination and dosage compensation in XX animals.
Heme peroxidase HPX-2 protects Caenorhabditis elegans from pathogens.
The SKPO-1 peroxidase functions in the hypodermis to protect Caenorhabditis elegans from bacterial infection.
FMRFamide-related gene family in the nematode, Caenorhabditis elegans.
Sexually Dimorphic Differentiation of a C. elegans Hub Neuron Is Cell Autonomously Controlled by a Conserved Transcription Factor.
Cloning, preliminary characterization and crystallization of nucleoside hydrolases from Caenorhabditis elegans and Campylobacter jejuni.
Structural and biochemical characterization of the nucleoside hydrolase from C. elegans reveals the role of two active site cysteine residues in catalysis.
C. elegans Rassf homolog, rasf-1, is functionally associated with rab-39 Rab GTPase in oxidative stress response.
Characterization of RSF-1, the Caenorhabditis elegans homolog of the Ras-association domain family protein 1.
Regulation of physiological rates in Caenorhabditis elegans by a tRNA-modifying enzyme in the mitochondria.
Biochemical properties of nematode O-acetylserine(thiol)lyase paralogs imply their distinct roles in hydrogen sulfide homeostasis.
Epidermal growth factor signaling induces behavioral quiescence in Caenorhabditis elegans.
FMRFamide-like neuropeptides and mechanosensory touch receptor neurons regulate male sexual turning behavior in Caenorhabditis elegans.
Insulin, cGMP, and TGF-beta signals regulate food intake and quiescence in C. elegans: a model for satiety.
Monoamines and neuropeptides interact to inhibit aversive behaviour in Caenorhabditis elegans.
Neurosecretory control of aging in Caenorhabditis elegans.
Presynaptic UNC-31 (CAPS) is required to activate the G(alpha)s pathway of the Caenorhabditis elegans synaptic signaling network.
The Caenorhabditis elegans unc-31 gene affects multiple nervous system-controlled functions.
A cyclic nucleotide-gated channel inhibits sensory axon outgrowth in larval and adult Caenorhabditis elegans: a distinct pathway for maintenance of sensory axon structure.
Dissecting the signaling mechanisms underlying recognition and preference of food odors.
Environmental alkalinity sensing mediated by the transmembrane guanylyl cyclase GCY-14 in C. elegans.
Mutations in a cyclic nucleotide-gated channel lead to abnormal thermosensation and chemosensation in C. elegans.
Receptor-type guanylate cyclase is required for carbon dioxide sensation by Caenorhabditis elegans.
The homeodomain protein hmbx-1 maintains asymmetric gene expression in adult C. elegans olfactory neurons.
CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation.
C. elegans ksr-1 and ksr-2 have both unique and redundant functions and are required for MPK-1 ERK phosphorylation.
Coordination of Recombination with Meiotic Progression in the Caenorhabditis elegans Germline by KIN-18, a TAO Kinase That Regulates the Timing of MPK-1 Signaling.
The NM23-H1/H2 homolog NDK-1 is required for full activation of Ras signaling in C. elegans.
C. elegans PAT-9 is a nuclear zinc finger protein critical for the assembly of muscle attachments.
NHR-80 senses the mitochondrial UPR to rewire citrate metabolism for lipid accumulation in Caenorhabditis elegans.
Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit.
Caenorhabditis elegans embryonic axial patterning requires two recently discovered posterior-group Hox genes.
Expression in yeast of an acyl-CoA:diacylglycerol acyltransferase cDNA from Caenorhabditis elegans.
Novel structural arrangement of nematode cystathionine beta-synthases: characterization of Caenorhabditis elegans CBS-1.
Prostaglandin signals from adult germ stem cells delay somatic aging of Caenorhabditis elegans.
PPM-1, a PP2Calpha/beta phosphatase, regulates axon termination and synapse formation in Caenorhabditis elegans.
New genes with roles in the C. elegans embryo revealed using RNAi of ovary-enriched ORFeome clones.
COG-2, a sox domain protein necessary for establishing a functional vulval-uterine connection in Caenorhabditis elegans.
EGL-13/SoxD specifies distinct O2 and CO2 sensory neuron fates in Caenorhabditis elegans.
The EGL-13 SOX domain transcription factor affects the uterine pi cell lineages in Caenorhabditis elegans.
FLR-2, the glycoprotein hormone alpha subunit, is involved in the neural control of intestinal functions in Caenorhabditis elegans.
Centriole assembly requires both centriolar and pericentriolar material proteins.
SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells.
Structural basis of the 9-fold symmetry of centrioles.
The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size.
Caenorhabditis cDNA encodes an eIF-4A-like protein.
Functional characterization of KIN-32, the Caenorhabditis elegans homolog of focal adhesion kinase.
Microtubule severing by the katanin complex is activated by PPFR-1-dependent MEI-1 dephosphorylation.
The role of protein phosphatase 4 in regulating microtubule severing in the Caenorhabditis elegans embryo.
Yeast Mon2p is a highly conserved protein that functions in the cytoplasm-to-vacuole transport pathway and is required for Golgi homeostasis.
The NK-2 class homeodomain factor CEH-51 and the T-box factor TBX-35 have overlapping function in C. elegans mesoderm development.
Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway.
The NED-8 conjugating system in Caenorhabditis elegans is required for embryogenesis and terminal differentiation of the hypodermis.
A combinatorial regulatory signature controls terminal differentiation of the dopaminergic nervous system in C. elegans.
Roles of the Homothorax/Meis/Prep homolog UNC-62 and the Exd/Pbx homologs CEH-20 and CEH-40 in C. elegans embryogenesis.
Ionizing radiations in Caenorhabditis elegans induce poly(ADP-ribosyl)ation, a conserved DNA-damage response essential for survival.
The genes pme-1 and pme-2 encode two poly(ADP-ribose) polymerases in Caenorhabditis elegans.
SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery.
The Caenorhabditis elegans spe-39 gene is required for intracellular membrane reorganization during spermatogenesis.
LIP-1 phosphatase controls the extent of germline proliferation in Caenorhabditis elegans.
Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 during C. elegans vulval development.
The C.elegans MAPK phosphatase LIP-1 is required for the G(2)/M meiotic arrest of developing oocytes.
The Ras-ERK MAPK regulatory network controls dedifferentiation in Caenorhabditis elegans germline.
Actomyosin tube formation in polar body cytokinesis requires Anillin in C. elegans.
Anillin promotes astral microtubule-directed cortical myosin polarization.
Caenorhabditis elegans anillin (ani-1) regulates neuroblast cytokinesis and epidermal morphogenesis during embryonic development.
Distinct roles for two C. elegans anillins in the gonad and early embryo.
Differential function of the two Atg4 homologues in the aggrephagy pathway in Caenorhabditis elegans.
ECA39, a conserved gene regulated by c-Myc in mice, is involved in G1/S cell cycle regulation in yeast.
Multiple RGS proteins alter neural G protein signaling to allow C. elegans to rapidly change behavior when fed.
A direct interaction between IP(3) receptors and myosin II regulates IP(3) signaling in C. elegans.
Protein structural domains in the Caenorhabditis elegans unc-54 myosin heavy chain gene are not separated by introns.
Sequence analysis of the complete Caenorhabditis elegans myosin heavy chain gene family.
Active turnover modulates mature microRNA activity in Caenorhabditis elegans.
Functional genomic analysis of C. elegans molting.
PAXT-1 promotes XRN2 activity by stabilizing it through a conserved domain.
Structural basis and function of XRN2 binding by XTB domains.
Target-mediated protection of endogenous microRNAs in C. elegans.
The decapping scavenger enzyme DCS-1 controls microRNA levels in Caenorhabditis elegans.
Defining the role of phosphomethylethanolamine N-methyltransferase from Caenorhabditis elegans in phosphocholine biosynthesis by biochemical and kinetic analysis.
Sensory organ remodeling in Caenorhabditis elegans requires the zinc-finger protein ZTF-16.
hunchback and Ikaros-like zinc finger genes control reproductive system development in Caenorhabditis elegans.
Identification of C. elegans sensory ray genes using whole-genome expression profiling.
C. elegans pharyngeal morphogenesis requires both de novo synthesis of pyrimidines and synthesis of heparan sulfate proteoglycans.
Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway.
sqv mutants of Caenorhabditis elegans are defective in vulval epithelial invagination.
sqv-3, -7, and -8, a set of genes affecting morphogenesis in Caenorhabditis elegans, encode enzymes required for glycosaminoglycan biosynthesis.
A gain-of-function mutation in oma-1, a C. elegans gene required for oocyte maturation, results in delayed degradation of maternal proteins and embryonic lethality.
An eIF4E-binding protein regulates katanin protein levels in C. elegans embryos.
DYRK2 and GSK-3 phosphorylate and promote the timely degradation of OMA-1, a key regulator of the oocyte-to-embryo transition in C. elegans.
Global transcriptional repression in C. elegans germline precursors by regulated sequestration of TAF-4.
Multiple maternal proteins coordinate to restrict the translation of C. elegans nanos-2 to primordial germ cells.
Novel family of CCCH-type zinc-finger proteins, MOE-1, -2 and -3, participates in C. elegans oocyte maturation.
OMA-1 is a P granules-associated protein that is required for germline specification in Caenorhabditis elegans embryos.
zif-1 translational repression defines a second, mutually exclusive OMA function in germline transcriptional repression.
Control of nonapoptotic developmental cell death in Caenorhabditis elegans by a polyglutamine-repeat protein.
Specificity of DNA-binding by the FAX-1 and NHR-67 nuclear receptors of Caenorhabditis elegans is partially mediated via a subclass-specific P-box residue.
The C. elegans tailless/Tlx homolog nhr-67 regulates a stage-specific program of linker cell migration in male gonadogenesis.
Transcriptional control of non-apoptotic developmental cell death in C. elegans.
ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans.
A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes.
C. elegans EVI1 proto-oncogene, EGL-43, is necessary for Notch-mediated cell fate specification and regulates cell invasion.
Migrations of the Caenorhabditis elegans HSNs are regulated by egl-43, a gene encoding two zinc finger proteins.
Regulation of anchor cell invasion and uterine cell fates by the egl-43 Evi-1 proto-oncogene in Caenorhabditis elegans.
The Caenorhabditis elegans gene ham-2 links Hox patterning to migration of the HSN motor neuron.
The Caenorhabditis elegans homolog of the Evi1 proto-oncogene, egl-43, coordinates G1 cell cycle arrest with pro-invasive gene expression during anchor cell invasion.
Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection.
Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt).
Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation.
The Caenorhabditis elegans unc-60 gene encodes proteins homologous to a family of actin-binding proteins.
Forgetting is regulated via Musashi-mediated translational control of the Arp2/3 complex.
Characterization of the astacin family of metalloproteases in C. elegans.
Developmental functions for the Caenorhabditis elegans Sp protein SPTF-3.
Identifying Regulators of Morphogenesis Common to Vertebrate Neural Tube Closure and Caenorhabditis elegans Gastrulation.
Ribosome 18S m6A methyltransferase METTL5 promotes translation initiation and breast cancer cell growth.
A network of PUF proteins and Ras signaling promote mRNA repression and oogenesis in C. elegans.
Divergence of Pumilio/fem-3 mRNA binding factor (PUF) protein specificity through variations in an RNA-binding pocket.
The RNA-binding proteins PUF-5, PUF-6, and PUF-7 reveal multiple systems for maternal mRNA regulation during C. elegans oogenesis.
nos-1 and nos-2, two genes related to Drosophila nanos, regulate primordial germ cell development and survival in Caenorhabditis elegans.
Myrf ER-bound transcription factors drive C. elegans synaptic plasticity via cleavage-dependent nuclear translocation.
Regulation of the C. elegans molt by pqn-47.
The LRR-TM protein PAN-1 interacts with MYRF to promote its nuclear translocation in synaptic remodeling.
ced-4 and proto-oncogene tfg-1 antagonistically regulate cell size and apoptosis in C. elegans.
A tRNA processing enzyme is a key regulator of the mitochondrial unfolded protein response.
The Caenorhabditis elegans homolog of the putative prostate cancer susceptibility gene ELAC2, hoe-1, plays a role in germline proliferation.
Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster.
Isolation and characterization of the activated B-cell factor 1 homolog in Caenorhabditis elegans.
A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication.
Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development.
Insulin worms its way into the spotlight.
Caenorhabditis elegans LET-767 is able to metabolize androgens and estrogens and likely shares common ancestor with human types 3 and 12 17beta-hydroxysteroid dehydrogenases.
LET-767 is required for the production of branched chain and long chain fatty acids in Caenorhabditis elegans.
The sterol modifying enzyme LET-767 is essential for growth, reproduction and development in Caenorhabditis elegans.
RNA-binding proteins SOP-2 and SOR-1 form a novel PcG-like complex in C. elegans.
C. elegans MOM-5/frizzled functions in MOM-2/Wnt-independent cell polarity and is localized asymmetrically prior to cell division.
Cell intrinsic modulation of Wnt signaling controls neuroblast migration in C. elegans.
Deconvolving the roles of Wnt ligands and receptors in sensing and amplification.
Establishment of POP-1 asymmetry in early C. elegans embryos.
MOM-5 frizzled regulates the distribution of DSH-2 to control C. elegans asymmetric neuroblast divisions.
Multiple redundant Wnt signaling components function in two processes during C. elegans vulval development.
The Wnt frizzled receptor MOM-5 regulates the UNC-5 Netrin receptor through small GTPase-dependent signaling to determine the polarity of migrating cells.
The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac.
The conserved transmembrane RING finger protein PLR-1 downregulates Wnt signaling by reducing Frizzled, Ror and Ryk cell-surface levels in C. elegans.
Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos.
Wnt signaling polarizes an early C. elegans blastomere to distinguish endoderm from mesoderm.
Identification and characterization of the vesicular GABA transporter.
GLB-13 is associated with oxidative stress resistance in Caenorhabditis elegans.
A conserved mitochondrial surveillance pathway is required for defense against Pseudomonas aeruginosa.
A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.
C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span.
Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor.
The DAF-2 insulin-like signaling pathway independently regulates aging and immunity in C. elegans.
Protein tyrosine phosphatase domains from the protochordate Styela plicata.
CeVPS-27 is an endosomal protein required for the molting and the endocytic trafficking of the low-density lipoprotein receptor-related protein 1 in Caenorhabditis elegans.
MVB-12, a fourth subunit of metazoan ESCRT-I, functions in receptor downregulation.
Regulated trafficking of the MSP/Eph receptor during oocyte meiotic maturation in C. elegans.
A 44 bp intestine-specific hermaphrodite-specific enhancer from the C. elegans vit-2 vitellogenin gene is directly regulated by ELT-2, MAB-3, FKH-9 and DAF-16 and indirectly regulated by the germline, by daf-2/insulin signaling and by the TGF-beta/Sma/Mab pathway.
A conserved role for a GATA transcription factor in regulating epithelial innate immune responses.
A modular system of DNA enhancer elements mediates tissue-specific activation of transcription by high dietary zinc in C. elegans.
An iron enhancer element in the FTN-1 gene directs iron-dependent expression in Caenorhabditis elegans intestine.
Burkholderia pseudomallei suppresses Caenorhabditis elegans immunity by specific degradation of a GATA transcription factor.
Direct visualization of the elt-2 gut-specific GATA factor binding to a target promoter inside the living Caenorhabditis elegans embryo.
ELT-2 is the predominant transcription factor controlling differentiation and function of the C. elegans intestine, from embryo to adult.
Endoderm development in Caenorhabditis elegans: the synergistic action of ELT-2 and -7 mediates the specification-differentiation transition.
GATA transcription factor required for immunity to bacterial and fungal pathogens.
Gene transcription is coordinated with, but not dependent on, cell divisions during C. elegans embryonic fate specification.
Genetic and physiological activation of osmosensitive gene expression mimics transcriptional signatures of pathogen infection in C. elegans.
HIF-1 regulates iron homeostasis in Caenorhabditis elegans by activation and inhibition of genes involved in iron uptake and storage.
Innate immune genes including a mucin-like gene, mul-1, induced by ionizing radiation in Caenorhabditis elegans.
Mode of bacterial pathogenesis determines phenotype in elt-2 and elt-7 RNAi Caenorhabditis elegans.
Non-proteolytic activity of 19S proteasome subunit RPT-6 regulates GATA transcription during response to infection.
Notch-GATA synergy promotes endoderm-specific expression of ref-1 in C. elegans.
Oxidative stress in Caenorhabditis elegans: protective effects of the Omega class glutathione transferase (GSTO-1).
Phylum-level conservation of regulatory information in nematodes despite extensive non-coding sequence divergence.
Recovery from an acute infection in C. elegans requires the GATA transcription factor ELT-2.
Regulation of sphingosine-1-phosphate lyase gene expression by members of the GATA family of transcription factors.
TOR signaling couples oxygen sensing to lifespan in C. elegans.
The DM domain transcription factor MAB-3 regulates male hypersensitivity to oxidative stress in Caenorhabditis elegans.
The ELT-2 GATA-factor and the global regulation of transcription in the C. elegans intestine.
The Function and Regulation of the GATA Factor ELT-2 in the C. elegans Endoderm.
The GATA-factor elt-2 is essential for formation of the Caenorhabditis elegans intestine.
Transcription factors GATA/ELT-2 and forkhead/HNF-3/PHA-4 regulate the tropomyosin gene expression in the pharynx and intestine of Caenorhabditis elegans.
Transcriptional control and patterning of the pho-1 gene, an essential acid phosphatase expressed in the C. elegans intestine.
Variability in gene expression underlies incomplete penetrance.
elt-2, a second GATA factor from the nematode Caenorhabditis elegans.
Comprehensive single cell-resolution analysis of the role of chromatin regulators in early C. elegans embryogenesis.
Neuronal calmodulin levels are controlled by CAMTA transcription factors.
SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast.
Mesodermal expression of the C. elegans HMX homolog mls-2 requires the PBC homolog CEH-20.
The C. elegans SoxC protein SEM-2 opposes differentiation factors to promote a proliferative blast cell fate in the postembryonic mesoderm.
Direct and heterologous approaches to identify the LET-756/FGF interactome.
FGF negatively regulates muscle membrane extension in Caenorhabditis elegans.
Interpreting a sequenced genome: toward a cosmid transgenic library of Caenorhabditis elegans.
Of worms and men: an evolutionary perspective on the fibroblast growth factor (FGF) and FGF receptor families.
Mutations in a C. elegans Gqalpha gene disrupt movement, egg laying, and viability.
A Forward Genetic Screen for Molecules Involved in Pheromone-Induced Dauer Formation in Caenorhabditis elegans.
Crescerin uses a TOG domain array to regulate microtubules in the primary cilium.
The conserved proteins CHE-12 and DYF-11 are required for sensory cilium function in Caenorhabditis elegans.
An autosomal recessive polycystic kidney disease gene homolog is involved in intraflagellar transport in C. elegans ciliated sensory neurons.
Co-chaperone p23 regulates C. elegans lifespan in response to temperature.
Genes that act downstream of sensory neurons to influence longevity, dauer formation, and pathogen responses in Caenorhabditis elegans.
Mutations affecting the chemosensory neurons of Caenorhabditis elegans.
Sensory control of dauer larva formation in Caenorhabditis elegans.
An unexpected role for the conserved ADAM-family metalloprotease ADM-2 in Caenorhabditis elegans molting.
Caenorhabditis elegans ivermectin receptors regulate locomotor behaviour and are functional orthologues of Haemonchus contortus receptors.
Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans.
Principles of activation and permeation in an anion-selective Cys-loop receptor.
X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.
Cloning by synteny: identifying C. briggsae homologues of C. elegans genes.
Cloning of cDNA for the gamma-subunit of mammalian translation initiation factor 2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2.
Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis.
The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans.
The MADD-3 LAMMER kinase interacts with a p38 MAP kinase pathway to regulate the display of the EVA-1 guidance receptor in Caenorhabditis elegans.
A monoclonal antibody toolkit for C. elegans.
DAF-16-dependent and independent expression targets of DAF-2 insulin receptor-like pathway in Caenorhabditis elegans include FKBPs.
Genetic control of nucleolar size: An evolutionary perspective.
Mutation of a Nopp140 gene dao-5 alters rDNA transcription and increases germ cell apoptosis in C. elegans.
A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans.
Caenorhabditis elegans mitofilin homologs control the morphology of mitochondrial cristae and influence reproduction and physiology.
Coordinated inhibition of C/EBP by Tribbles in multiple tissues is essential for Caenorhabditis elegans development.
Functional Dissection of C. elegans bZip-Protein CEBP-1 Reveals Novel Structural Motifs Required for Axon Regeneration and Nuclear Import.
Methylmercury Induces Metabolic Alterations in Caenorhabditis elegans: Role for C/EBP Transcription Factor.
Microtubule depolymerization in Caenorhabditis elegans touch receptor neurons reduces gene expression through a p38 MAPK pathway.
The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration.
Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caenorhabditis elegans intestinal immune surveillance pathway.
Tribbles pseudokinase NIPI-3 regulates intestinal immunity in Caenorhabditis elegans by controlling SKN-1/Nrf activity.
An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state.
Expression of rib-1, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes, is indispensable for heparan sulfate synthesis and embryonic morphogenesis.
The structure of the human multiple exostoses 2 gene and characterization of homologs in mouse and Caenorhabditis elegans.
rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate.
Crystal structure of Zen4 in the apo state reveals a missing conformation of kinesin.
Cytokinesis and midzone microtubule organization in Caenorhabditis elegans require the kinesin-like protein ZEN-4.
Stressed-induced TMEM135 protein is part of a conserved genetic network involved in fat storage and longevity regulation in Caenorhabditis elegans.
Caenorhabditis elegans RMI2 functional homolog-2 (RMIF-2) and RMI1 (RMH-1) have both overlapping and distinct meiotic functions within the BTR complex.
Evolution of the RECQ family of helicases: a Drosophila homolog, Dmblm, is similar to the human Bloom syndrome gene.
GTPase-mediated regulation of the unfolded protein response in Caenorhabditis elegans is dependent on the AAA+ ATPase CDC-48.
Separable roles for a Caenorhabditis elegans RMI1 homolog in promoting and antagonizing meiotic crossovers ensure faithful chromosome inheritance.
The SMC-5/6 complex and the HIM-6 (BLM) helicase synergistically promote meiotic recombination intermediate processing and chromosome maturation during Caenorhabditis elegans meiosis.
Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells.
Comparative proteomic analysis reveals differentially expressed proteins in Caenorhabditis elegans pgl-1 mutants grown at 20 degrees C and 25 degrees C.
BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.
Coordinate regulation of lipid metabolism by novel nuclear receptor partnerships.
Dual Role of an mps-2/KCNE-Dependent Pathway in Long-Term Memory and Age-Dependent Memory Decline.
Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation.
The small GTPase Arf1 modulates mitochondrial morphology and function.
TBC-8, a putative RAB-2 GAP, regulates dense core vesicle maturation in Caenorhabditis elegans.
Two Rab2 interactors regulate dense-core vesicle maturation.
Identification of novel chondroitin proteoglycans in Caenorhabditis elegans: embryonic cell division depends on CPG-1 and CPG-2.
The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types.
C. elegans aging is modulated by hydrogen sulfide and the sulfhydrylase/cysteine synthase cysl-2.
The response of Caenorhabditis elegans to hydrogen sulfide and hydrogen cyanide.
Biochemical properties of Caenorhabditis elegans HMG-5, a regulator of mitochondrial DNA.
Identification of HMG-5 as a double-stranded telomeric DNA-binding protein in the nematode Caenorhabditis elegans.
C. elegans La-related protein, LARP-1, localizes to germline P bodies and attenuates Ras-MAPK signaling during oogenesis.
LARP-1 promotes oogenesis by repressing fem-3 in the C. elegans germline.
A complex of LIN-5 and GPR proteins regulates G protein signaling and spindle function in C elegans.
A compartmentalized signaling network mediates crossover control in meiosis.
BRCA1-BARD1 associate with the synaptonemal complex and pro-crossover factors and influence RAD-51 dynamics during Caenorhabditis elegans meiosis.
C. elegans ZHP-4 is required at multiple distinct steps in the formation of crossovers and their transition to segregation competent chiasmata.
Targeted gene knockout reveals a role in meiotic recombination for ZHP-3, a Zip3-related protein in Caenorhabditis elegans.
ZHP-3 acts at crossovers to couple meiotic recombination with synaptonemal complex disassembly and bivalent formation in C. elegans.
MORC family ATPases required for heterochromatin condensation and gene silencing.
MORC-1 integrates nuclear RNAi and transgenerational chromatin architecture to promote germline immortality.
The Gene-Silencing Protein MORC-1 Topologically Entraps DNA and Forms Multimeric Assemblies to Cause DNA Compaction.
C. elegans nuclear receptor NHR-6 functionally interacts with the jun-1 transcription factor during spermatheca development.
Caenorhabditis elegans FOS-1 and JUN-1 regulate plc-1 expression in the spermatheca to control ovulation.
Co-regulation by Notch and Fos is required for cell fate specification of intermediate precursors during C. elegans uterine development.
Sequence comparisons of developmentally regulated collagen genes of Caenorhabditis elegans.
The AP-2 Transcription Factor APTF-2 Is Required for Neuroblast and Epidermal Morphogenesis in Caenorhabditis elegans Embryogenesis.
C. elegans peb-1 mutants exhibit pleiotropic defects in molting, feeding, and morphology.
DNA binding and in vivo function of C.elegans PEB-1 require a conserved FLYWCH motif.
Interference between the PHA-4 and PEB-1 transcription factors in formation of the Caenorhabditis elegans pharynx.
The Caenorhabditis elegans peb-1 gene encodes a novel DNA-binding protein involved in morphogenesis of the pharynx, vulva, and hindgut.
Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor.
The mitochondrial prohibitin complex is essential for embryonic viability and germline function in Caenorhabditis elegans.
Cloning and expression of human core 1 beta1,3-galactosyltransferase.
Identification of core 1 O-glycan T-synthase from Caenorhabditis elegans.
Caenorhabditis elegans MES-3 is a target of GLD-1 and functions epigenetically in germline development.
Phenotypic and molecular analysis of mes-3, a maternal-effect gene required for proliferation and viability of the germ line in C. elegans.
Regulation of the different chromatin states of autosomes and X chromosomes in the germ line of C. elegans.
The Caenorhabditis elegans maternal-effect sterile proteins, MES-2, MES-3, and MES-6, are associated in a complex in embryos.
Functional analysis of the methylmalonyl-CoA epimerase from Caenorhabditis elegans.
SEL-5, a serine/threonine kinase that facilitates lin-12 activity in Caenorhabditis elegans.
Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans.
NOCA-1 Functions with gamma-tubulin and in parallel to Patronin to assemble non-centrosomal microtubule arrays in C. elegans.
Identification of spatial and temporal cues that regulate postembryonic expression of axon maintenance factors in the C. elegans ventral nerve cord.
LIN-14 inhibition of LIN-12 contributes to precision and timing of C. elegans vulval fate patterning.
Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development.
Neuronal function of the mRNA decapping complex determines survival of Caenorhabditis elegans at high temperature through temporal regulation of heterochronic gene expression.
Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28.
The Caenorhabditis elegans heterochronic gene lin-14 coordinates temporal progression and maturation in the egg-laying system.
The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin/insulin-like growth factor gene ins-33 by direct DNA binding.
The heterochronic LIN-14 protein is a BEN domain transcription factor.
The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein.
Analysis of FMRFamide-like peptide (FLP) diversity in phylum Nematoda.
C. elegans Stress-Induced Sleep Emerges from the Collective Action of Multiple Neuropeptides.
Combinatorial RNA interference indicates GLH-4 can compensate for GLH-1; these two P granule components are critical for fertility in C. elegans.
Wide diversity in structure and expression profiles among members of the Caenorhabditis elegans globin protein family.
Cloning and characterization of uracil-DNA glycosylase and the biological consequences of the loss of its function in the nematode Caenorhabditis elegans.
Loss of Caenorhabditis elegans UNG-1 uracil-DNA glycosylase affects apoptosis in response to DNA damaging agents.
dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C.elegans vulval development.
Deciphering the Role of EGL-3 for Neuropeptides Processing in Caenorhabditis elegans Using High-Resolution Quadrupole-Orbitrap Mass Spectrometry.
Backbone-independent nucleic acid binding by splicing factor SUP-12 reveals key aspects of molecular recognition.
RBFOX and SUP-12 sandwich a G base to cooperatively regulate tissue-specific splicing.
Distinct roles of the two VPS33 proteins in the endolysosomal system in Caenorhabditis elegans.
Loss of the Sec1/Munc18-family proteins VPS-33.2 and VPS-33.1 bypasses a block in endosome maturation in Caenorhabditis elegans.
The FoxF/FoxC factor LET-381 directly regulates both cell fate specification and cell differentiation in C. elegans mesoderm development.
A RAC/CDC-42-independent GIT/PIX/PAK signaling pathway mediates cell migration in C. elegans.
Isolation of the gene coding for Caenorhabditis elegans Rac2 homologue, a Ras-related small GTP-binding protein.
Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway.
Clathrin-mediated endocytosis is required for compensatory regulation of GLR-1 glutamate receptors after activity blockade.
EAT-4, a homolog of a mammalian sodium-dependent inorganic phosphate cotransporter, is necessary for glutamatergic neurotransmission in caenorhabditis elegans.
G alphas-induced neurodegeneration in Caenorhabditis elegans.
Mutations of the caenorhabditis elegans brain-specific inorganic phosphate transporter eat-4 affect habituation of the tap-withdrawal response without affecting the response itself.
Neuronal toxicity in Caenorhabditis elegans from an editing site mutant in glutamate receptor channels.
Genomic organization of the glyceraldehyde-3-phosphate dehydrogenase gene family of Caenorhabditis elegans.
A family of unconventional myosins from the nematode Caenorhabditis elegans.
A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes.
Caenorhabditis elegans UNC-98, a C2H2 Zn finger protein, is a novel partner of UNC-97/PINCH in muscle adhesion complexes.
Molecular mechanism of activation of the immunoregulatory amidase NAAA.
The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis.
LIN-61, one of two Caenorhabditis elegans malignant-brain-tumor-repeat-containing proteins, acts with the DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes.
The Caenorhabditis elegans protein FIC-1 is an AMPylase that covalently modifies heat-shock 70 family proteins, translation elongation factors and histones.
Functional characterization of SR and SR-related genes in Caenorhabditis elegans.
SPK-1, a C. elegans SR protein kinase homologue, is essential for embryogenesis and required for germline development.
Loss of Caenorhabditis elegans BRCA1 promotes genome stability during replication in smc-5 mutants.
Structural maintenance of chromosomes (SMC) proteins promote homolog-independent recombination repair in meiosis crucial for germ cell genomic stability.
Activation of hypodermal differentiation in the Caenorhabditis elegans embryo by GATA transcription factors ELT-1 and ELT-3.
An ECM-to-Nucleus Signaling Pathway Activates Lysosomes for C. elegans Larval Development.
ELT-3: A Caenorhabditis elegans GATA factor expressed in the embryonic epidermis during morphogenesis.
Re-evaluating the role of ELT-3 in a GATA transcription factor circuit proposed to guide aging in C. elegans.
Reconciliation of daf-2 suppression by elt-3 in Caenorhabditis elegans from Tonsaker et al. (2012) and Kim et al. (2012).
The Oxidative Stress Response in Caenorhabditis elegans Requires the GATA Transcription Factor ELT-3 and SKN-1/Nrf2.
In situ imaging in C. elegans reveals developmental regulation of microtubule dynamics.
Kinesin-13 and tubulin posttranslational modifications regulate microtubule growth in axon regeneration.
Nna1-like proteins are active metallocarboxypeptidases of a new and diverse M14 subfamily.
A genome-wide survey and systematic RNAi-based characterization of helicase-like genes in Caenorhabditis elegans.
Different Mi-2 complexes for various developmental functions in Caenorhabditis elegans.
Evolutionary plasticity in the innate immune function of Akirin.
MEP-1 and a homolog of the NURD complex component Mi-2 act together to maintain germline-soma distinctions in C. elegans.
The C. elegans Mi-2 chromatin-remodelling proteins function in vulval cell fate determination.
The Mi-2 nucleosome-remodeling protein LET-418 is targeted via LIN-1/ETS to the promoter of lin-39/Hox during vulval development in C. elegans.
Regulation of C. elegans presynaptic differentiation and neurite branching via a novel signaling pathway initiated by SAM-10.
The C. elegans LIM homeobox gene lin-11 specifies multiple cell fates during vulval development.
The Caenorhabditis elegans Ldb/NLI/Clim orthologue ldb-1 is required for neuronal function.
A conserved family of proteins facilitates nascent lipid droplet budding from the ER.
AST-1, a novel ETS-box transcription factor, controls axon guidance and pharynx development in C. elegans.
Gene regulatory logic of dopamine neuron differentiation.
A post-docking role for active zone protein Rim.
CFL-1, a novel F-box protein with leucine-rich repeat may interact with UNC-10 for the regulation of defecation and daumone response in Caenorhabditis elegans.
Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi.
CLEC-38, a transmembrane protein with C-type lectin-like domains, negatively regulates UNC-40-mediated axon outgrowth and promotes presynaptic development in Caenorhabditis elegans.
Functional redundancy of two nucleoside transporters of the ENT family (CeENT1, CeENT2) required for development of Caenorhabditis elegans.
Identification, localization, and functional implications of an abundant nematode annexin.
BLMP-1/Blimp-1 regulates the spatiotemporal cell migration pattern in C. elegans.
DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation.
Direct and positive regulation of Caenorhabditis elegans bed-3 by PRDM1/BLIMP1 ortholog BLMP-1.
An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK.
A C. elegans Ror receptor tyrosine kinase regulates cell motility and asymmetric cell division.
Control of DAF-7 TGF-(alpha) expression and neuronal process development by a receptor tyrosine kinase KIN-8 in Caenorhabditis elegans.
Evolutionary divergence in the catalytic activity of the CAM-1, ROR1 and ROR2 kinase domains.
Functional analysis of the domains of the C elegans Ror receptor tyrosine kinase CAM-1.
Genes necessary for C. elegans cell and growth cone migrations.
Identification of Caenorhabditis elegans genes required for neuronal differentiation and migration.
Isolation and characterization of high-temperature-induced Dauer formation mutants in Caenorhabditis elegans.
The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway.
The Caenorhabditis elegans Ror RTK CAM-1 inhibits EGL-20/Wnt signaling in cell migration.
The C. elegans SYS-1 protein is a bona fide beta-catenin.
Autophagy genes are essential for dauer development and life-span extension in C. elegans.
Autophagy genes function sequentially to promote apoptotic cell corpse degradation in the engulfing cell.
Non-selective autophagy reduces mitochondrial content during starvation in Caenorhabditis elegans.
The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans.
The cell non-autonomous function of ATG-18 is essential for neuroendocrine regulation of Caenorhabditis elegans lifespan.
Structural genomics of Caenorhabditis elegans: structure of dihydropteridine reductase.
Acute carbon dioxide avoidance in Caenorhabditis elegans.
Control of C. elegans larval development by neuronal expression of a TGF-beta homolog.
PDF-1 neuropeptide signaling regulates sexually dimorphic gene expression in shared sensory neurons of C. elegans.
The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development.
A conserved tetraspanin subfamily promotes Notch signaling in Caenorhabditis elegans and in human cells.
EFN-4 functions in LAD-2-mediated axon guidance in Caenorhabditis elegans.
Genetics of extracellular matrix remodeling during organ growth using the Caenorhabditis elegans pharynx model.
Identification and characterization of genes that interact with lin-12 in Caenorhabditis elegans.
SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling.
Two paralogous tetraspanins TSP-12 and TSP-14 function with the ADAM10 metalloprotease SUP-17 to promote BMP signaling in caenorhabditis elegans.
Nuclear cGMP-dependent kinase regulates gene expression via activity-dependent recruitment of a conserved histone deacetylase complex.
Regulation of rnt-1 expression mediated by the opposing effects of BRO-1 and DBL-1 in the nematode Caenorhabditis elegans.
The C. elegans CBFbeta homologue BRO-1 interacts with the Runx factor, RNT-1, to promote stem cell proliferation and self-renewal.
Identification and reverse genetic analysis of mitochondrial processing peptidase and the core protein of the cytochrome bc1 complex of Caenorhabditis elegans, a model parasitic nematode.
MBR-1, a novel helix-turn-helix transcription factor, is required for pruning excessive neurites in Caenorhabditis elegans.
The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway.
Antifungal innate immunity in C. elegans: PKCdelta links G protein signaling and a conserved p38 MAPK cascade.
Two-dimensional gel electrophoresis of Caenorhabditis elegans homogenates and identification of protein spots by microsequencing.
A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex.
Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation.
SPDL-1 functions as a kinetochore receptor for MDF-1 in Caenorhabditis elegans.
HSF-1 regulators DDL-1/2 link insulin-like signaling to heat-shock responses and modulation of longevity.
Functional analysis of GS28, an intra-Golgi SNARE, in Caenorhabditis elegans.
Caenorhabditis elegans Rab escort protein (REP-1) differently regulates each Rab protein function and localization in a tissue-dependent manner.
Critical residues of the Caenorhabditis elegans unc-2 voltage-gated calcium channel that affect behavioral and physiological properties.
Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue.
Soluble guanylate cyclases act in neurons exposed to the body fluid to promote C. elegans aggregation behavior.
A Bub1-Mad1 interaction targets the Mad1-Mad2 complex to unattached kinetochores to initiate the spindle checkpoint.
Functional analysis of kinetochore assembly in Caenorhabditis elegans.
Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin.
Kinetochore-localized BUB-1/BUB-3 complex promotes anaphase onset in C. elegans.
Systematic analysis in Caenorhabditis elegans reveals that the spindle checkpoint is composed of two largely independent branches.
The function of a spindle checkpoint gene bub-1 in C. elegans development.
Caenorhabditis elegans kettin, a large immunoglobulin-like repeat protein, binds to filamentous actin and provides mechanical stability to the contractile apparatuses in body wall muscle.
Kettin, the large actin-binding protein with multiple immunoglobulin domains, is essential for sarcomeric actin assembly and larval development in Caenorhabditis elegans.
Molecular and biochemical characterization of kettin in Caenorhabditis elegans.
Requirements of Kettin, a giant muscle protein highly conserved in overall structure in evolution, for normal muscle function, viability, and flight activity of Drosophila.
Sequence and expression of the kettin gene in Drosophila melanogaster and Caenorhabditis elegans.
Evolution tunes the excitability of individual neurons.
The Caenorhabditis elegans iodotyrosine deiodinase ortholog SUP-18 functions through a conserved channel SC-box to regulate the muscle two-pore domain potassium channel SUP-9.
sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans.
C. elegans interprets bacterial non-coding RNAs to learn pathogenic avoidance.
Macoilin, a conserved nervous system-specific ER membrane protein that regulates neuronal excitability.
Novel and conserved protein macoilin is required for diverse neuronal functions in Caenorhabditis elegans.
The C. elegans protein CEH-30 protects male-specific neurons from apoptosis independently of the Bcl-2 homolog CED-9.
Gene conversion and DNA sequence polymorphism in the sex-determination gene fog-2 and its paralog ftr-1 in Caenorhabditis elegans.
NHR-14 loss of function couples intestinal iron uptake with innate immunity in C. elegans through PQM-1 signaling.
Suppression of the ELO-2 FA elongation activity results in alterations of the fatty acid composition and multiple physiological defects, including abnormal ultradian rhythms, in Caenorhabditis elegans.
The Bro1-domain protein, EGO-2, promotes Notch signaling in Caenorhabditis elegans.
Efficient chaperone-mediated tubulin biogenesis is essential for cell division and cell migration in C. elegans.
Dietary manipulation implicates lipid signaling in the regulation of germ cell maintenance in C. elegans.
Fluoxetine-resistance genes in Caenorhabditis elegans function in the intestine and may act in drug transport.
Fluoxetine-resistant mutants in C. elegans define a novel family of transmembrane proteins.
A universal transportin protein drives stochastic choice of olfactory neurons via specific nuclear import of a sox-2-activating factor.
Transcriptional regulation and stabilization of left-right neuronal identity in C. elegans.
Discovery and characterization of a conserved pigment dispersing factor-like neuropeptide pathway in Caenorhabditis elegans.
Multiple regulatory changes contribute to the evolution of the Caenorhabditis lin-48 ovo gene.
The bZip proteins CES-2 and ATF-2 alter the timing of transcription for a cell-specific target gene in C. elegans.
Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2.
A novel role for alpha-importins and Akirin in establishment of meiotic sister chromatid cohesion in Caenorhabditis elegans.
Akirin is required for muscle function and acts through the TGF-beta Sma/Mab signaling pathway in Caenorhabditis elegans development.
akirin is required for diakinesis bivalent structure and synaptonemal complex disassembly at meiotic prophase I.
APY-1, a novel Caenorhabditis elegans apyrase involved in unfolded protein response signalling and stress responses.
mRNA decapping is an evolutionarily conserved modulator of neuroendocrine signaling that controls development and ageing.
Novel calcineurin interacting protein-2: the functional characterization of CNP-2 in Caenorhabditis elegans.
CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling.
Fndc-1 contributes to paternal mitochondria elimination in C. elegans.
Ubiquitination is required for the initial removal of paternal organelles in C. elegans.
LIN41 post-transcriptionally silences mRNAs by two distinct and position-dependent mechanisms.
Novel gain-of-function alleles demonstrate a role for the heterochronic gene lin-41 in C. elegans male tail tip morphogenesis.
Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation.
The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor.
When LIN41 comes to a fork in the road, it takes BOTH paths: translational repression OR mRNA decay, depending on the target site position.
acn-1, a C. elegans homologue of ACE, genetically interacts with the let-7 microRNA and other heterochronic genes.
dmd-3, a doublesex-related gene regulated by tra-1, governs sex-specific morphogenesis in C. elegans.
let-7 coordinates the transition to adulthood through a single primary and four secondary targets.
Functional redundancy between two Caenorhabditis elegans nucleotide sugar transporters with a novel transport mechanism.
Loss of srf-3-encoded nucleotide sugar transporter activity in Caenorhabditis elegans alters surface antigenicity and prevents bacterial adherence.
srf-3, a mutant of Caenorhabditis elegans, resistant to bacterial infection and to biofilm binding, is deficient in glycoconjugates.
Casein Kinase 1delta Stabilizes Mature Axons by Inhibiting Transcription Termination of Ankyrin.
Developmental timing in C. elegans is regulated by kin-20 and tim-1, homologs of core circadian clock genes.
The Doubletime Homolog KIN-20 Mainly Regulates let-7 Independently of Its Effects on the Period Homolog LIN-42 in Caenorhabditis elegans.
Multiple forms of histone H2B from the nematode Caenorhabditis elegans.
ATX-3, CDC-48 and UBXN-5: a new trimolecular complex in Caenorhabditis elegans.
An Afg2/Spaf-related Cdc48-like AAA ATPase regulates the stability and activity of the C. elegans Aurora B kinase AIR-2.
Caenorhabditis elegans p97/CDC-48 is crucial for progression of meiosis I.
Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin.
Characterization of C-terminal adaptors, UFD-2 and UFD-3, of CDC-48 on the polyglutamine aggregation in C. elegans.
Comparative analysis of expression of two p97 homologues in Caenorhabditis elegans.
E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis.
ER E3 ubiquitin ligase HRD-1 and its specific partner chaperone BiP play important roles in ERAD and developmental growth in Caenorhabditis elegans.
Genome-wide screen identifies a novel p97/CDC-48-dependent pathway regulating ER-stress-induced gene transcription.
High-speed atomic force microscopic observation of ATP-dependent rotation of the AAA+ chaperone p97.
Involvement of the actin cytoskeleton and homotypic membrane fusion in ER dynamics in Caenorhabditis elegans.
Positive cooperativity of the p97 AAA ATPase is critical for essential functions.
The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis.
The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A.
The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy.
p97 Homologs from Caenorhabditis elegans, CDC-48.1 and CDC-48.2, suppress the aggregate formation of huntingtin exon1 containing expanded polyQ repeat.
Identification of paracaspases and metacaspases. Two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma.
The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C. elegans.
Genome structure, mapping and expression of the tropomyosin gene tmy-1 of Caenorhabditis elegans.
Integration of male mating and feeding behaviors in Caenorhabditis elegans.
Muscle arm development in Caenorhabditis elegans.
Mutations and expressions of the tropomyosin gene and the troponin C gene of Caenorhabditis elegans.
The third and fourth tropomyosin isoforms of Caenorhabditis elegans are expressed in the pharynx and intestines and are essential for development and morphology.
Tropomyosin inhibits ADF/cofilin-dependent actin filament dynamics.
UNC-87, a calponin-related protein in C. elegans, antagonizes ADF/cofilin-mediated actin filament dynamics.
Caenorhabditis elegans HSF-1 is an essential nuclear protein that forms stress granule-like structures following heat shock.
Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans.
E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response.
HSF-1 activates the ubiquitin proteasome system to promote non-apoptotic developmental cell death in C. elegans.
HSF-1 is a regulator of miRNA expression in Caenorhabditis elegans.
HSF-1 is involved in regulation of ascaroside pheromone biosynthesis by heat stress in Caenorhabditis elegans.
Heat-shock transcription factor (HSF)-1 pathway required for Caenorhabditis elegans immunity.
Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans.
Olfactory experience primes the heat shock transcription factor HSF-1 to enhance the expression of molecular chaperones in C. elegans.
The homeodomain-interacting protein kinase HPK-1 preserves protein homeostasis and longevity through master regulatory control of the HSF-1 chaperone network and TORC1-restricted autophagy in Caenorhabditis elegans.
Mechanistic insights into central spindle assembly mediated by the centralspindlin complex.
Identification and functional expression of the plasma membrane calcium ATPase gene family from Caenorhabditis elegans.
Multiple Ca(2+)-calmodulin-dependent protein kinase kinases from rat brain. Purification, regulation by Ca(2+)-calmodulin, and partial amino acid sequence.
Substrate recognition by Ca2+/Calmodulin-dependent protein kinase kinase. Role of the arg-pro-rich insert domain.
A regulatory cascade of three transcription factors in a single specific neuron, DVC, in Caenorhabditis elegans.
Mg2+ extrusion from intestinal epithelia by CNNM proteins is essential for gonadogenesis via AMPK-TORC1 signaling in Caenorhabditis elegans.
cDNA sequence, gene structure, and cholinesterase-like domains of an esterase from Caenorhabditis elegans mapped to chromosome V.
The role of mitochondria in the life of the nematode, Caenorhabditis elegans.
A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination.
Exclusion of germ plasm proteins from somatic lineages by cullin-dependent degradation.
The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components.
Heparan 2-O-sulfotransferase, hst-2, is essential for normal cell migration in Caenorhabditis elegans.
Heparan sulphate sulphotransferase expression in mice and Caenorhabditis elegans.
Characterization of PUD-1 and PUD-2, two proteins up-regulated in a long-lived daf-2 mutant.
Biosynthesis of truncated N-linked oligosaccharides results from non-orthologous hexosaminidase-mediated mechanisms in nematodes, plants, and insects.
Cell-Autonomous and Non-Cell-Autonomous Regulation of a Feeding State-Dependent Chemoreceptor Gene via MEF-2 and bHLH Transcription Factors.
Characterization of CeHDA-7, a class II histone deacetylase interacting with MEF-2 in Caenorhabditis elegans.
KIN-29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDAC.
The EGL-4 PKG acts with KIN-29 salt-inducible kinase and protein kinase A to regulate chemoreceptor gene expression and sensory behaviors in Caenorhabditis elegans.
The MADS-Box factor CeMEF2 is not essential for Caenorhabditis elegans myogenesis and development.
The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions.
A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C. elegans.
Tyrosine aminotransferase is involved in the oxidative stress response by metabolizing meta-tyrosine in Caenorhabditis elegans.
Nato3 is an evolutionarily conserved bHLH transcription factor expressed in the CNS of Drosophila and mouse.
The P-type ATPase CATP-1 is a novel regulator of C. elegans developmental timing that acts independently of its predicted pump function.
A family of K+ channel ancillary subunits regulate taste sensitivity in Caenorhabditis elegans.
Maturation of the major ubiquitin gene transcript in Caenorhabditis elegans involves the acquisition of a trans-spliced leader.
UbiA, the major polyubiquitin locus in Caenorhabditis elegans, has unusual structural features and is constitutively expressed.
A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb.
Asymmetric segregation of PIE-1 in C. elegans is mediated by two complementary mechanisms that act through separate PIE-1 protein domains.
Inhibition of transcription by the Caenorhabditis elegans germline protein PIE-1: genetic evidence for distinct mechanisms targeting initiation and elongation.
PIE-1 Translation in the Germline Lineage Contributes to PIE-1 Asymmetry in the Early Caenorhabditis elegans Embryo.
PIE-1 is a bifunctional protein that regulates maternal and zygotic gene expression in the embryonic germ line of Caenorhabditis elegans.
Repression of gene expression in the embryonic germ lineage of C. elegans.
The PIE-1 protein and germline specification in C. elegans embryos.
The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos.
Mextli proteins use both canonical bipartite and novel tripartite binding modes to form eIF4E complexes that display differential sensitivity to 4E-BP regulation.
Synapsis-dependent and -independent mechanisms stabilize homolog pairing during meiotic prophase in C. elegans.
The C. elegans MDL-1 and MXL-1 proteins can functionally substitute for vertebrate MAD and MAX.
Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans.
HTZ-1/H2A.z and MYS-1/MYST HAT act redundantly to maintain cell fates in somatic gonadal cells through repression of ceh-22 in C. elegans.
A novel zf-MYND protein, CHB-3, mediates guanylyl cyclase localization to sensory cilia and controls body size of Caenorhabditis elegans.
Guanylyl cyclase expression in specific sensory neurons: a new family of chemosensory receptors.
The importance of cGMP signaling in sensory cilia for body size regulation in Caenorhabditis elegans.
A chemoreceptor that detects molecular carbon dioxide.
SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans.
The notch regulator MAML1 interacts with p53 and functions as a coactivator.
Two classes of active transcription sites and their roles in developmental regulation.
DYC-1, a protein functionally linked to dystrophin in Caenorhabditis elegans is associated with the dense body, where it interacts with the muscle LIM domain protein ZYX-1.
Genetic suppression of phenotypes arising from mutations in dystrophin-related genes in Caenorhabditis elegans.
Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4.
Cell-type specific regulation of serotonergic identity by the C. elegans LIM-homeodomain factor LIM-4.
LIM homeobox gene-dependent expression of biogenic amine receptors in restricted regions of the C. elegans nervous system.
Postmitotic diversification of olfactory neuron types is mediated by differential activities of the HMG-box transcription factor SOX-2.
The Evolutionarily Conserved LIM Homeodomain Protein LIM-4/LHX6 Specifies the Terminal Identity of a Cholinergic and Peptidergic C. elegans Sensory/Inter/Motor Neuron-Type.
Anabolic function of phenylalanine hydroxylase in Caenorhabditis elegans.
Combined extracellular matrix cross-linking activity of the peroxidase MLT-7 and the dual oxidase BLI-3 is critical for post-embryonic viability in Caenorhabditis elegans.
NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans.
Proline Catabolism Modulates Innate Immunity in Caenorhabditis elegans.
Tetraspanin is required for generation of reactive oxygen species by the dual oxidase system in Caenorhabditis elegans.
The BLI-3/TSP-15/DOXA-1 dual oxidase complex is required for iodide toxicity in Caenorhabditis elegans.
Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox.
A Caenorhabditis elegans protein with a PRDM9-like SET domain localizes to chromatin-associated foci and promotes spermatocyte gene expression, sperm production and fertility.
ELT-1, a GATA-like transcription factor, is required for epidermal cell fates in Caenorhabditis elegans embryos.
Regulation of sperm gene expression by the GATA factor ELT-1.
The Caenorhabditis elegans GATA factor ELT-1 works through the cell proliferation regulator BRO-1 and the Fusogen EFF-1 to maintain the seam stem-like fate.
The Caenorhabditis elegans GATA factor elt-1 is essential for differentiation and maintenance of hypodermal seam cells and for normal locomotion.
The GATA factor elt-1 regulates C. elegans developmental timing by promoting expression of the let-7 family microRNAs.
elt-1, an embryonically expressed Caenorhabditis elegans gene homologous to the GATA transcription factor family.
Expression of a globin gene in Caenorhabditis elegans.
Globin-like proteins in Caenorhabditis elegans: in vivo localization, ligand binding and structural properties.
Novel gene structure and evolutionary context of Caenorhabditis elegans globin.
Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf.
Restriction of mesendoderm to a single blastomere by the combined action of SKN-1 and a GSK-3beta homolog is mediated by MED-1 and -2 in C. elegans.
A Disease Model of Muscle Necrosis Caused by Aeromonas dhakensis Infection in Caenorhabditis elegans.
Bacillus thuringiensis Crystal Protein Cry6Aa Triggers Caenorhabditis elegans Necrosis Pathway Mediated by Aspartic Protease (ASP-1).
Analysis of smu-1, a gene that regulates the alternative splicing of unc-52 pre-mRNA in Caenorhabditis elegans.
SMU-2 and SMU-1, Caenorhabditis elegans homologs of mammalian spliceosome-associated proteins RED and fSAP57, work together to affect splice site choice.
Structural Basis for the Functional Coupling of the Alternative Splicing Factors Smu1 and RED.
DNA Methylation on N(6)-Adenine in C. elegans.
Genomic structure of three CLN3-like genes in Caenorhabditis elegans.
The secreted immunoglobulin domain proteins ZIG-5 and ZIG-8 cooperate with L1CAM/SAX-7 to maintain nervous system integrity.
The small, secreted immunoglobulin protein ZIG-3 maintains axon position in Caenorhabditis elegans.
The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis.
Distinct innate immune responses to infection and wounding in the C. elegans epidermis.
Identification of neuropeptide-like protein gene families in Caenorhabditis elegans and other species.
Innate Immunity Promotes Sleep through Epidermal Antimicrobial Peptides.
TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM.
A strawberry notch homolog, let-765/nsh-1, positively regulates lin-3/egf expression to promote RAS-dependent vulval induction in C. elegans.
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.
UNC-11, a Caenorhabditis elegans AP180 homologue, regulates the size and protein composition of synaptic vesicles.
Depletion of the C. elegans NAC engages the unfolded protein response, resulting in increased chaperone expression and apoptosis.
A molecular switch that governs mitochondrial fusion and fission mediated by the BCL2-like protein CED-9 of Caenorhabditis elegans.
Bcl-2 proteins EGL-1 and CED-9 do not regulate mitochondrial fission or fusion in Caenorhabditis elegans.
DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans.
The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9.
The Snail-like CES-1 protein of C. elegans can block the expression of the BH3-only cell-death activator gene egl-1 by antagonizing the function of bHLH proteins.
The abts and sulp families of anion transporters from Caenorhabditis elegans.
UNC-83 coordinates kinesin-1 and dynein activities at the nuclear envelope during nuclear migration.
Regulation of the myosin-directed chaperone UNC-45 by a novel E3/E4-multiubiquitylation complex in C. elegans.
UFD-2 is an adaptor-assisted E3 ligase targeting unfolded proteins.
Assembly of C. elegans apical junctions involves positioning and compaction by LET-413 and protein aggregation by the MAGUK protein DLG-1.
Cooperative regulation of AJM-1 controls junctional integrity in Caenorhabditis elegans epithelia.
DLG-1 is a MAGUK similar to SAP97 and is required for adherens junction formation.
Dynamic analysis identifies novel roles for DLG-1 subdomains in AJM-1 recruitment and LET-413-dependent apical focusing.
Caenorhabditis elegans SORB-1 localizes to integrin adhesion sites and is required for organization of sarcomeres and mitochondria in myocytes.
Structural components of the nonstriated contractile apparatuses in the Caenorhabditis elegans gonadal myoepithelial sheath and their essential roles for ovulation.
The basal component of the nematode dense-body is vinculin.
Novel roles of Caenorhabditis elegans heterochromatin protein HP1 and linker histone in the regulation of innate immune gene expression.
Transcriptional repression of Hox genes by C. elegans HP1/HPL and H1/HIS-24.
Unique and redundant functions of C. elegans HP1 proteins in post-embryonic development.
A Toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signaling.
A neuronal signaling pathway of CaMKII and Gqalpha regulates experience-dependent transcription of tph-1.
Calcineurin, a calcium/calmodulin-dependent protein phosphatase, is involved in movement, fertility, egg laying, and growth in Caenorhabditis elegans.
D1 dopamine receptor signaling is modulated by the R7 RGS protein EAT-16 and the R7 binding protein RSBP-1 in Caenoerhabditis elegans motor neurons.
Diverse behavioural defects caused by mutations in Caenorhabditis elegans unc-43 CaM kinase II.
Eph and NMDA receptors control Ca2+/calmodulin-dependent protein kinase II activation during C. elegans oocyte meiotic maturation.
Food deprivation attenuates seizures through CaMKII and EAG K+ channels.
Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation.
Intestinal Ca2+ wave dynamics in freely moving C. elegans coordinate execution of a rhythmic motor program.
Lateral signaling mediated by axon contact and calcium entry regulates asymmetric odorant receptor expression in C. elegans.
Microtubule-based localization of a synaptic calcium-signaling complex is required for left-right neuronal asymmetry in C. elegans.
Oligomerization states of the association domain and the holoenzyme of Ca2+/CaM kinase II.
Presynaptic Ca2+/calmodulin-dependent protein kinase II modulates neurotransmitter release by activating BK channels at Caenorhabditis elegans neuromuscular junction.
Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme.
The CaMKII UNC-43 activates the MAPKKK NSY-1 to execute a lateral signaling decision required for asymmetric olfactory neuron fates.
The Caenorhabditis elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43/CaMKII regulate neuromuscular junction morphology.
The effects of transient starvation persist through direct interactions between CaMKII and ether-a-go-go K+ channels in C. elegans males.
The role of regulatory domain interactions in UNC-43 CaMKII localization and trafficking.
A branched heterochronic pathway directs juvenile-to-adult transition through two LIN-29 isoforms.
A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport.
MAB-10/NAB acts with LIN-29/EGR to regulate terminal differentiation and the transition from larva to adult in C. elegans.
Mapping and analysis of Caenorhabditis elegans transcription factor sequence specificities.
New Roles for the Heterochronic Transcription Factor LIN-29 in Cuticle Maintenance and Lipid Metabolism at the Larval-to-Adult Transition in Caenorhabditis elegans.
Stage-specific accumulation of the terminal differentiation factor LIN-29 during Caenorhabditis elegans development.
The Caenorhabditis elegans heterochronic gene lin-29 coordinates the vulval-uterine-epidermal connections.
The LIN-29 transcription factor is required for proper morphogenesis of the Caenorhabditis elegans male tail.
The heterochronic gene lin-29 encodes a zinc finger protein that controls a terminal differentiation event in Caenorhabditis elegans.
The terminal differentiation factor LIN-29 is required for proper vulval morphogenesis and egg laying in Caenorhabditis elegans.
The human RNA 3'-terminal phosphate cyclase is a member of a new family of proteins conserved in Eucarya, Bacteria and Archaea.
A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites.
Characterization of Ce-atl-1, an ATM-like gene from Caenorhabditis elegans.
Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryos.
Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans.
cDNA sequence, gene structure, and in vitro expression of ace-1, the gene encoding acetylcholinesterase of class A in the nematode Caenorhabditis elegans.
The Ccr4-Not deadenylase complex constitutes the main poly(A) removal activity in C. elegans.
The RNase PARN-1 trims piRNA 3' ends to promote transcriptome surveillance in C. elegans.
Identification of lineage-specific zygotic transcripts in early Caenorhabditis elegans embryos.
The noncanonical binding site of the MED-1 GATA factor defines differentially regulated target genes in the C. elegans mesendoderm.
Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD.
Cellular and axonal migrations are misguided along both body axes in the maternal-effect mau-2 mutants of Caenorhabditis elegans.
Viable maternal-effect mutations that affect the development of the nematode Caenorhabditis elegans.
mau-2 acts cell-autonomously to guide axonal migrations in Caenorhabditis elegans.
Autophagy genes unc-51 and bec-1 are required for normal cell size in Caenorhabditis elegans.
Caenorhabditis elegans unc-51 gene required for axonal elongation encodes a novel serine/threonine kinase.
The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. elegans.
Caenorhabditits elegans LRK-1 and PINK-1 Act Antagonistically in Stress Response and Neurite Outgrowth.
LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins.
C. elegans mre-11 is required for meiotic recombination and DNA repair but is dispensable for the meiotic G(2) DNA damage checkpoint.
An essential ubiquitin-conjugating enzyme with tissue and developmental specificity in the nematode Caenorhabditis elegans.
The ubc-2 gene of Caenorhabditis elegans encodes a ubiquitin-conjugating enzyme involved in selective protein degradation.
Structure of the Regulatory Cytosolic Domain of a Eukaryotic Potassium-Chloride Cotransporter.
The lactate dehydrogenase gene from nematode Caenorhabditis elegans contains only two of six introns conserved in the protein-encoding sequence of LDH genes from bird and mammals.
The nucleotide and deduced amino-acid sequences of a cDNA encoding lactate dehydrogenase from Caenorhabditis elegans: the evolutionary relationships of lactate dehydrogenases from mammals, birds, amphibian, fish, nematode, plants, bacteria, mycoplasma, and plasmodium.
Endophilin functions as a membrane-bending molecule and is delivered to endocytic zones by exocytosis.
Endophilin is required for synaptic vesicle endocytosis by localizing synaptojanin.
Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity.
Dauer-specific dendrite arborization in C. elegans is regulated by KPC-1/Furin.
Glia initiate brain assembly through noncanonical Chimaerin-Furin axon guidance in C. elegans.
Isolation of a cDNA encoding a Kex2-like endoprotease with homology to furin from the nematode Caenorhabditis elegans.
Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions.
The proprotein convertase KPC-1/furin controls branching and self-avoidance of sensory dendrites in Caenorhabditis elegans.
A tachykinin-like neuroendocrine signalling axis couples central serotonin action and nutrient sensing with peripheral lipid metabolism.
Cloning, structure, and expression of the gene for a novel regulatory subunit of cAMP-dependent protein kinase in Caenorhabditis elegans.
Differential requirements for STRAD in LKB1-dependent functions in C. elegans.
FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores.
Folliculin regulates ampk-dependent autophagy and metabolic stress survival.
S6 kinase inhibits intrinsic axon regeneration capacity via AMP kinase in Caenorhabditis elegans.
The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans.
The Caenorhabditis elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and is required for resistance to oxidative stress and for normal motility and foraging behavior.
The primary structure of a minor isoform (H1.2) of histone H1 from the nematode Caenorhabditis elegans.
Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin.
SEL-10/Fbw7-dependent negative feedback regulation of LIN-45/Braf signaling in C. elegans via a conserved phosphodegron.
SKR-1, a homolog of Skp1 and a member of the SCF(SEL-10) complex, regulates sex-determination and LIN-12/Notch signaling in C. elegans.
Spatial regulation of an E3 ubiquitin ligase directs selective synapse elimination.
Suppressors of a lin-12 hypomorph define genes that interact with both lin-12 and glp-1 in Caenorhabditis elegans.
The C. elegans F-box proteins LIN-23 and SEL-10 antagonize centrosome duplication by regulating ZYG-1 levels.
The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome.
Bacillus thuringiensis (Bt) toxin susceptibility and isolation of resistance mutants in the nematode Caenorhabditis elegans.
Molecular cloning and enzymatic characterization of a UDP-GalNAc:GlcNAc(beta)-R beta1,4-N-acetylgalactosaminyltransferase from Caenorhabditis elegans.
Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin-host interactions.
A POP-1 repressor complex restricts inappropriate cell type-specific gene transcription during Caenorhabditis elegans embryogenesis.
Functional requirement for histone deacetylase 1 in Caenorhabditis elegans gonadogenesis.
Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity.
Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex.
The PLZF-like protein TRA-4 cooperates with the Gli-like transcription factor TRA-1 to promote female development in C. elegans.
lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48.
Nuclear envelope phosphatase-regulatory subunit 1 (formerly TMEM188) is the metazoan SPO7 ortholog and functions in the lipin activation pathway.
A redox signalling globin is essential for reproduction in Caenorhabditis elegans.
Identification and functional characterization of the Caenorhabditis elegans riboflavin transporters rft-1 and rft-2.
A conserved role for SNX9-family members in the regulation of phagosome maturation during engulfment of apoptotic cells.
Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development.
Three sorting nexins drive the degradation of apoptotic cells in response to PtdIns(3)P signaling.
Two PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3)P critical for the degradation of apoptotic cells.
Behavioral defects in C. elegans egl-36 mutants result from potassium channels shifted in voltage-dependence of activation.
EGL-36 Shaw channels regulate C. elegans egg-laying muscle activity.
Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways.
The RNA phosphatase PIR-1 regulates endogenous small RNA pathways in C. elegans.
A homeotic gene cluster patterns the anteroposterior body axis of C. elegans.
Caenorhabditis elegans mutants defective in the functioning of the motor neurons responsible for egg laying.
Cloning and analysis of three new homeobox genes from the nematode Caenorhabditis elegans.
Control of cell fate in the tail region of C. elegans by the gene egl-5.
EGL-5/ABD-B plays an instructive role in male cell fate determination in the C. elegans somatic gonad.
Patterning of Caenorhabditis elegans posterior structures by the Abdominal-B homolog, egl-5.
The C. elegans Hox gene egl-5 is required for correct development of the hermaphrodite hindgut and for the response to rectal infection by Microbacterium nematophilum.
The Caenorhabditis elegans spalt-like gene sem-4 restricts touch cell fate by repressing the selector Hox gene egl-5 and the effector gene mec-3.
The T-box gene tbx-2, the homeobox gene egl-5 and the asymmetric cell division gene ham-1 specify neural fate in the HSN/PHB lineage.
The LIN-15A and LIN-56 transcriptional regulators interact to negatively regulate EGF/Ras signaling in Caenorhabditis elegans vulval cell-fate determination.
Antisense ribosomal siRNAs inhibit RNA polymerase I-directed transcription in C. elegans.
FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegans.
Patterning of the C. elegans 1 degrees vulval lineage by RAS and Wnt pathways.
A Na+/Cl- -coupled GABA transporter, GAT-1, from Caenorhabditis elegans: structural and functional features, specific expression in GABA-ergic neurons, and involvement in muscle function.
The Caenorhabditis elegans snf-11 gene encodes a sodium-dependent GABA transporter required for clearance of synaptic GABA.
The four cdc25 genes from the nematode Caenorhabditis elegans.
Caenorhabditis elegans N-glycan core beta-galactoside confers sensitivity towards nematotoxic fungal galectin CGL2.
Fucosyltransferase substrate specificity and the order of fucosylation in invertebrates.
Guanine nucleotide exchange factor OSG-1 confers functional aging via dysregulated Rho signaling in Caenorhabditis elegans neurons.
Dephosphorylation of cell cycle-regulated proteins correlates with anoxia-induced suspended animation in Caenorhabditis elegans.
HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase.
HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans.
HIF-1 modulates longevity and healthspan in a temperature-dependent manner.
Hydrogen sulfide increases hypoxia-inducible factor-1 activity independently of von Hippel-Lindau tumor suppressor-1 in C. elegans.
Hypoxia activates a latent circuit for processing gustatory information in C. elegans.
Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity.
The Caenorhabditis elegans hif-1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia.
The histones of Caenorhabditis elegans: no evidence of stage-specific isoforms. An overview.
An extensive requirement for transcription factor IID-specific TAF-1 in Caenorhabditis elegans embryonic transcription.
TBP-like factor is required for embryonic RNA polymerase II transcription in C. elegans.
The TBP-like factor CeTLF is required to activate RNA polymerase II transcription during C. elegans embryogenesis.
The TBP-like factor: an alternative transcription factor in metazoa?
A role for peroxidasin PXN-1 in aspects of C. elegans development.
Genetic Suppression of Basement Membrane Defects in Caenorhabditis elegans by Gain of Function in Extracellular Matrix and Cell-Matrix Attachment Genes.
The C. elegans peroxidasin PXN-2 is essential for embryonic morphogenesis and inhibits adult axon regeneration.
pxn-1 and pxn-2 May Interact Negatively during Neuronal Development and Aging in C. elegans.
Similarity of the C. elegans developmental timing protein LIN-42 to circadian rhythm proteins.
LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining.
chk-1 is an essential gene and is required for an S-M checkpoint during early embryogenesis.
Sex- and age-dependent genetics of longevity in a heterogeneous mouse population.
Whole-organism developmental expression profiling identifies rab-28 as a novel ciliary GTPase associated with the BBSome and intraflagellar transport.
Phosphoethanolamine N-methyltransferase (PMT-1) catalyses the first reaction of a new pathway for phosphocholine biosynthesis in Caenorhabditis elegans.
Caenorhabditis elegans HOPS and CCZ-1 mediate trafficking to lysosome-related organelles independently of RAB-7 and SAND-1.
Correction: Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.
Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.
Defective processing of neuropeptide precursors in Caenorhabditis elegans lacking proprotein convertase 2 (KPC-2/EGL-3): mutant analysis by mass spectrometry.
Centriolar SAS-7 acts upstream of SPD-2 to regulate centriole assembly and pericentriolar material formation.
PCMD-1 bridges the centrioles and the pericentriolar material scaffold in C. elegans.
CNP-1 (ARRD-17), a novel substrate of calcineurin, is critical for modulation of egg-laying and locomotion in response to food and lysine sensation in Caenorhabditis elegans.
A phenylalanine hydroxylase gene from the nematode C. elegans is expressed in the hypodermis.
The Caenorhabditis elegans K10C2.4 gene encodes a member of the fumarylacetoacetate hydrolase family: a Caenorhabditis elegans model of type I tyrosinemia.
SWAP pre-mRNA splicing regulators are a novel, ancient protein family sharing a highly conserved sequence motif with the prp21 family of constitutive splicing proteins.
Worms taste bitter: ASH neurons, QUI-1, GPA-3 and ODR-3 mediate quinine avoidance in Caenorhabditis elegans.
Regulation of Caenorhabditis elegans body size and male tail development by the novel gene lon-8.
MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability.
The MXL-3/SBP-1 Axis Is Responsible for Glucose-Dependent Fat Accumulation in C. elegans.
Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1.
The hermaphrodite sperm/oocyte switch requires the Caenorhabditis elegans homologs of PRP2 and PRP22.
EGL-27 is similar to a metastasis-associated factor and controls cell polarity and cell migration in C. elegans.
Members of the NODE (Nanog and Oct4-associated deacetylase) complex and SOX-2 promote the initiation of a natural cellular reprogramming event in vivo.
The Caenorhabditis elegans genes egl-27 and egr-1 are similar to MTA1, a member of a chromatin regulatory complex, and are redundantly required for embryonic patterning.
The GATA transcription factor egl-27 delays aging by promoting stress resistance in Caenorhabditis elegans.
Structure and properties of a bis-histidyl ligated globin from Caenorhabditis elegans.
The Caenorhabditis globin gene family reveals extensive nematode-specific radiation and diversification.
Human skeletal muscle nebulin sequence encodes a blueprint for thin filament architecture. Sequence motifs and affinity profiles of tandem repeats and terminal SH3.
Cloning and comparative mapping of a gene from the commonly deleted region of DiGeorge and Velocardiofacial syndromes conserved in C. elegans.
Systematic analyses of rpm-1 suppressors reveal roles for ESS-2 in mRNA splicing in Caenorhabditis elegans.
A more desirable balanced polyunsaturated fatty acid composition achieved by heterologous expression of Delta15/Delta4 desaturases in mammalian cells.
Caenorhabditis elegans Delta12-desaturase FAT-2 is a bifunctional desaturase able to desaturate a diverse range of fatty acid substrates at the Delta12 and Delta15 positions.
Identification of an animal omega-3 fatty acid desaturase by heterologous expression in Arabidopsis.
Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids.
Functional identification of a fatty acid delta5 desaturase gene from Caenorhabditis elegans.
Isolation and characterization of a Delta 5-fatty acid desaturase from Caenorhabditis elegans.
Defining the transcriptional redundancy of early bodywall muscle development in C. elegans: evidence for a unified theory of animal muscle development.
Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions.
UNC-120/SRF independently controls muscle aging and lifespan in Caenorhabditis elegans.
cDNA cloning and gene mapping of human homologs for Schizosaccharomyces pombe rad17, rad1, and hus1 and cloning of homologs from mouse, Caenorhabditis elegans, and Drosophila melanogaster.
Structure-function analysis of an evolutionary conserved protein, DAP3, which mediates TNF-alpha- and Fas-induced cell death.
The nephronophthisis-related gene ift-139 is required for ciliogenesis in Caenorhabditis elegans.
CRAC channel activity in C. elegans is mediated by Orai1 and STIM1 homologues and is essential for ovulation and fertility.
Physiological roles of STIM1 and Orai1 homologs and CRAC channels in the genetic model organism Caenorhabditis elegans.
Otx-dependent expression of proneural bHLH genes establishes a neuronal bilateral asymmetry in C. elegans.
The Bicoid class homeodomain factors ceh-36/OTX and unc-30/PITX cooperate in C. elegans embryonic progenitor cells to regulate robust development.
The C. elegans ceh-36 gene encodes a putative homeodomain transcription factor involved in chemosensory functions of ASE and AWC neurons.
Increased longevity of some C. elegans mitochondrial mutants explained by activation of an alternative energy-producing pathway.
MISC-1/OGC links mitochondrial metabolism, apoptosis and insulin secretion.
A conserved postsynaptic transmembrane protein affecting neuromuscular signaling in Caenorhabditis elegans.
Cornichons control ER export of AMPA receptors to regulate synaptic excitability.
Unique homeobox codes delineate all the neuron classes of C. elegans.
MEI-1/MEI-2 katanin-like microtubule severing activity is required for Caenorhabditis elegans meiosis.
CeBRC-2 stimulates D-loop formation by RAD-51 and promotes DNA single-strand annealing.
Essential role of brc-2 in chromosome integrity of germ cells in C. elegans.
Paradoxical delay of senescence upon depletion of BRCA2 in telomerase-deficient worms.
RAD-51-dependent and -independent roles of a Caenorhabditis elegans BRCA2-related protein during DNA double-strand break repair.
Stabilization of RAD-51-DNA filaments via an interaction domain in Caenorhabditis elegans BRCA2.
The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development.
C. elegans fmi-1/flamingo and Wnt pathway components interact genetically to control the anteroposterior neurite growth of the VD GABAergic neurons.
Caenorhabditis elegans flamingo cadherin fmi-1 regulates GABAergic neuronal development.
The Flamingo ortholog FMI-1 controls pioneer-dependent navigation of follower axons in C. elegans.
Germline signaling mediates the synergistically prolonged longevity produced by double mutations in daf-2 and rsks-1 in C. elegans.
Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans.
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans.
S6K links cell fate, cell cycle and nutrient response in C. elegans germline stem/progenitor cells.
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.
Receptor-mediated endocytosis in the Caenorhabditis elegans oocyte.
Selenocysteine-containing thioredoxin reductase in C. elegans.
Selenoprotein TRXR-1 and GSR-1 are essential for removal of old cuticle during molting in Caenorhabditis elegans.
The Caenorhabditis elegans homologue of thioredoxin reductase contains a selenocysteine insertion sequence (SECIS) element that differs from mammalian SECIS elements but directs selenocysteine incorporation.
Melatonin signaling regulates locomotion behavior and homeostatic states through distinct receptor pathways in Caenorhabditis elegans.
A transcriptional regulatory cascade that controls left/right asymmetry in chemosensory neurons of C. elegans.
The C. elegans che-1 gene encodes a zinc finger transcription factor required for specification of the ASE chemosensory neurons.
Paired and LIM class homeodomain proteins coordinate differentiation of the C. elegans ALA neuron.
The homeodomain protein CePHOX2/CEH-17 controls antero-posterior axonal growth in C. elegans.
DNA replication defects delay cell division and disrupt cell polarity in early Caenorhabditis elegans embryos.
The Cdc20 homolog, FZY-1, and its interacting protein, IFY-1, are required for proper chromosome segregation in Caenorhabditis elegans.
Eukaryotic UDP-galactopyranose mutase (GLF gene) in microbial and metazoal pathogens.
High-affinity consensus binding of target RNAs by the STAR/GSG proteins GLD-1, STAR-2 and Quaking.
Muscle-specific splicing factors ASD-2 and SUP-12 cooperatively switch alternative pre-mRNA processing patterns of the ADF/cofilin gene in Caenorhabditis elegans.
STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo.
Properties, regulation, and in vivo functions of a novel protein kinase D: Caenorhabditis elegans DKF-2 links diacylglycerol second messenger to the regulation of stress responses and life span.
Protein kinase D is an essential regulator of C. elegans innate immunity.
Caenorhabditis elegans in the study of SMN-interacting proteins: a role for SMI-1, an orthologue of human Gemin2 and the identification of novel components of the SMN complex.
More mog genes that influence the switch from spermatogenesis to oogenesis in the hermaphrodite germ line of Caenorhabditis elegans.
The Caenorhabditis elegans DDX-23, a homolog of yeast splicing factor PRP28, is required for the sperm-oocyte switch and differentiation of various cell types.
The MEP-1 zinc-finger protein acts with MOG DEAH box proteins to control gene expression via the fem-3 3' untranslated region in Caenorhabditis elegans.
Isolation and characterization of a sperm-specific gene family in the nematode Caenorhabditis elegans.
Functional characterization of the putative orphan neuropeptide G-protein coupled receptor C26F1.6 in Caenorhabditis elegans.
Bm-CPI-2, a cystatin from Brugia malayi nematode parasites, differs from Caenorhabditis elegans cystatins in a specific site mediating inhibition of the antigen-processing enzyme AEP.
Developing a rapid throughput screen for detection of nematicidal activity of plant cysteine proteinases: the role of Caenorhabditis elegans cystatins.
Parasite-specific immunomodulatory functions of filarial cystatin.
RIC-3 affects properties and quantity of nicotinic acetylcholine receptors via a mechanism that does not require the coiled-coil domains.
The C. elegans ric-3 gene is required for maturation of nicotinic acetylcholine receptors.
Visualization of integral and peripheral cell surface proteins in live Caenorhabditis elegans.
Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans.
Functional redundancy of paralogs of an anaphase promoting complex/cyclosome subunit in Caenorhabditis elegans meiosis.
Mutual antagonism between the anaphase promoting complex and the spindle assembly checkpoint contributes to mitotic timing in Caenorhabditis elegans.
Suppressors of spindle checkpoint defect (such) mutants identify new mdf-1/MAD1 interactors in Caenorhabditis elegans.
Dynamic localization of SPE-9 in sperm: a protein required for sperm-oocyte interactions in Caenorhabditis elegans.
Functional domains and temperature-sensitive mutations in SPE-9, an EGF repeat-containing protein required for fertility in Caenorhabditis elegans.
Levels of DNA polymorphism vary with mating system in the nematode genus Caenorhabditis.
The C. elegans spe-9 gene encodes a sperm transmembrane protein that contains EGF-like repeats and is required for fertilization.
Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.
Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.
GCK-3, a newly identified Ste20 kinase, binds to and regulates the activity of a cell cycle-dependent ClC anion channel.
The Caenorhabditis elegans Ste20 kinase, GCK-3, is essential for postembryonic developmental timing and regulates meiotic chromosome segregation.
Tetrameric assembly of K(+) channels requires ER-located chaperone proteins.
Expression of ram-5 in the structural cell is required for sensory ray morphogenesis in Caenorhabditis elegans male tail.
SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans.
The C. elegans hook protein, ZYG-12, mediates the essential attachment between the centrosome and nucleus.
atz-1 Influences meiosis to maintain germline chromosomal stability in Caenorhabditis elegans.
Dense core vesicle dynamics in Caenorhabditis elegans neurons and the role of kinesin UNC-104.
IDA-1, a Caenorhabditis elegans homolog of the diabetic autoantigens IA-2 and phogrin, is expressed in peptidergic neurons in the worm.
Insulinoma-Associated Protein IA-2, a Vesicle Transmembrane Protein, Genetically Interacts with UNC-31/CAPS and Affects Neurosecretion in Caenorhabditis elegans.
Loss of the transcriptional repressor PAG-3/Gfi-1 results in enhanced neurosecretion that is dependent on the dense-core vesicle membrane protein IDA-1/IA-2.
Pioneer Axon Navigation Is Controlled by AEX-3, a Guanine Nucleotide Exchange Factor for RAB-3 in Caenorhabditis elegans.
The IA-2 gene family: homologs in Caenorhabditis elegans, Drosophila and zebrafish.
EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans.
Endocytosis function of a ligand-gated ion channel homolog in Caenorhabditis elegans.
A C. elegans Hox gene switches on, off, on and off again to regulate proliferation, differentiation and morphogenesis.
A C. elegans mediator protein confers regulatory selectivity on lineage-specific expression of a transcription factor gene.
MEX-3 interacting proteins link cell polarity to asymmetric gene expression in Caenorhabditis elegans.
Maternal control of a zygotic patterning gene in Caenorhabditis elegans.
Pairing of competitive and topologically distinct regulatory modules enhances patterned gene expression.
Polycomb group regulation of Hox gene expression in C. elegans.
Regulation of cellular responsiveness to inductive signals in the developing C. elegans nervous system.
Selective silencing of cell communication influences anteroposterior pattern formation in C. elegans.
Spatial and temporal controls target pal-1 blastomere-specification activity to a single blastomere lineage in C. elegans embryos.
Specification of the C. elegans MS blastomere by the T-box factor TBX-35.
The Wnt effector POP-1 and the PAL-1/Caudal homeoprotein collaborate with SKN-1 to activate C. elegans endoderm development.
The homeodomain protein PAL-1 specifies a lineage-specific regulatory network in the C. elegans embryo.
The maternal par genes and the segregation of cell fate specification activities in early Caenorhabditis elegans embryos.
The myogenic potency of HLH-1 reveals wide-spread developmental plasticity in early C. elegans embryos.
Zygotic expression of the caudal homolog pal-1 is required for posterior patterning in Caenorhabditis elegans embryogenesis.
LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required for normal Golgi function.
The architecture of kinesin-3 KLP-6 reveals a multilevel-lockdown mechanism for autoinhibition.
A neuronal acetylcholine receptor regulates the balance of muscle excitation and inhibition in Caenorhabditis elegans.
ACR-3, a Caenorhabditis elegans nicotinic acetylcholine receptor subunit. Molecular cloning and functional expression.
The role of dityrosine formation in the crosslinking of CUT-2, the product of a second cuticlin gene of Caenorhabditis elegans.
cut-1 a Caenorhabditis elegans gene coding for a dauer-specific noncollagenous component of the cuticle.
A novel small molecule that disrupts a key event during the oocyte-to-embryo transition in C. elegans.
Transcriptionally regulated cell adhesion network dictates distal tip cell directionality.
SLR-2 and JMJC-1 regulate an evolutionarily conserved stress-response network.
Widespread genetic incompatibility in C. elegans maintained by balancing selection.
Expression profiles of the essential intermediate filament (IF) protein A2 and the IF protein C2 in the nematode Caenorhabditis elegans.
mua-6, a gene required for tissue integrity in Caenorhabditis elegans, encodes a cytoplasmic intermediate filament.
Molecular cloning and characterization of a novel alpha 1,2-fucosyltransferase (CE2FT-1) from Caenorhabditis elegans.
The bromodomain protein LIN-49 and trithorax-related protein LIN-59 affect development and gene expression in Caenorhabditis elegans.
Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons.
The C. elegans avermectin resistance and anesthetic response gene unc-9 encodes a member of a protein family implicated in electrical coupling of excitable cells.
LEM-3 - a LEM domain containing nuclease involved in the DNA damage response in C. elegans.
LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis.
The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans.
MicroRNAs acting in a double-negative feedback loop to control a neuronal cell fate decision.
Alternatively spliced transcripts of the flp-1 gene encode distinct FMRFamide-like peptides in Caenorhabditis elegans.
Neuropeptides function in a homeostatic manner to modulate excitation-inhibition imbalance in C. elegans.
The flp-1 propeptide is processed into multiple, highly similar FMRFamide-like peptides in Caenorhabditis elegans.
The Caenorhabditis elegans gene ncc-1 encodes a cdc2-related kinase required for M phase in meiotic and mitotic cell divisions, but not for S phase.
Two cyclin-dependent kinase pathways are essential for polarized trafficking of presynaptic components.
The putative multidrug resistance protein MRP-7 inhibits methylmercury-associated animal toxicity and dopaminergic neurodegeneration in Caenorhabditis elegans.
Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins.
Distinct regulatory elements mediate similar expression patterns in the excretory cell of Caenorhabditis elegans.
DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans.
NURD-complex genes antagonise Ras-induced vulval development in Caenorhabditis elegans.
RbAp46/48(LIN-53) is required for holocentromere assembly in Caenorhabditis elegans.
Centriolar SAS-5 is required for centrosome duplication in C. elegans.
PP2A phosphatase acts upon SAS-5 to ensure centriole formation in C. elegans embryos.
CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo.
C. elegans molting requires rhythmic accumulation of the Grainyhead/LSF transcription factor GRH-1.
Functional conservation between members of an ancient duplicated transcription factor family, LSF/Grainyhead.
Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan.
MIG-10 (lamellipodin) has netrin-independent functions and is a FOS-1A transcriptional target during anchor cell invasion in C. elegans.
The novel C. elegans gene sop-3 modulates Wnt signaling to regulate Hox gene expression.
The 53BP1 homolog in C. elegans influences DNA repair and promotes apoptosis in response to ionizing radiation.
Functional expression and characterization of the C. elegans G-protein-coupled FLP-2 Receptor (T19F4.1) in mammalian cells and yeast.
Molecular characterization of two G protein-coupled receptor splice variants as FLP2 receptors in Caenorhabditis elegans.
Neuropeptide signals cell non-autonomous mitochondrial unfolded protein response.
The Neuropeptides FLP-2 and PDF-1 Act in Concert To Arouse Caenorhabditis elegans Locomotion.
Centrosome-associated degradation limits beta-catenin inheritance by daughter cells after asymmetric division.
The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly.
Bioinformatic and biochemical characterization of DCXR and DHRS2/4 from Caenorhabditis elegans.
Molecular cloning and developmental expression of the alpha-2 tubulin gene of Caenorhabditis elegans.
Intrinsically disordered protein PID-2 modulates Z granules and is required for heritable piRNA-induced silencing in the Caenorhabditis elegans embryo.
PID-1 is a novel factor that operates during 21U-RNA biogenesis in Caenorhabditis elegans.
A conserved metalloprotease mediates ecdysis in Caenorhabditis elegans.
Metalloproteases with EGF, CUB, and thrombospondin-1 domains function in molting of Caenorhabditis elegans.
Identification of new members of the (short) neuropeptide F family in locusts and Caenorhabditis elegans.
Molecular basis of anti-horseradish peroxidase staining in Caenorhabditis elegans.
Molecular cloning and characterization of the Caenorhabditis elegans alpha1,3-fucosyltransferase family.
Membrane localization of the NlpC/P60 family protein EGL-26 correlates with regulation of vulval cell morphogenesis in Caenorhabditis elegans.
The Caenorhabditis elegans EGL-26 protein mediates vulval cell morphogenesis.
ire-1-dependent transcriptional up-regulation of a lumenal uridine diphosphatase from Caenorhabditis elegans.
Dissection of the NUP107 nuclear pore subcomplex reveals a novel interaction with spindle assembly checkpoint protein MAD1 in Caenorhabditis elegans.
The C. elegans homolog of nucleoporin Nup98 is required for the integrity and function of germline P granules.
CDK-11-Cyclin L is required for gametogenesis and fertility in C. elegans.
The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle.
A functional NR4A nuclear receptor DNA-binding domain is required for organ development in Caenorhabditis elegans.
Steroid/thyroid hormone receptor genes in Caenorhabditis elegans.
The C. elegans NR4A nuclear receptor gene nhr-6 promotes cell cycle progression in the spermatheca lineage.
The Caenorhabditis elegans NR4A nuclear receptor is required for spermatheca morphogenesis.
A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation.
The insulin/PI 3-kinase pathway regulates salt chemotaxis learning in Caenorhabditis elegans.
A competition mechanism for a homeotic neuron identity transformation in C. elegans.
Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity.
Control of neuronal subtype identity by the C. elegans ARID protein CFI-1.
Mutations that lead to reiterations in the cell lineages of C. elegans.
Protein interaction surface of the POU transcription factor UNC-86 selectively used in touch neurons.
Regulation of the mec-3 gene by the C.elegans homeoproteins UNC-86 and MEC-3.
Regulation of touch receptor differentiation by the Caenorhabditis elegans mec-3 and unc-86 genes.
The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons.
The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors.
The LIM and POU homeobox genes ttx-3 and unc-86 act as terminal selectors in distinct cholinergic and serotonergic neuron types.
The POU transcription factor UNC-86 controls the timing and ventral guidance of Caenorhabditis elegans axon growth.
The unc-86 gene product couples cell lineage and cell identity in C. elegans.
Cloning and characterization of the choline acetyltransferase structural gene (cha-1) from C. elegans.
Caenorhabditis elegans TBX-2 Directly Regulates Its Own Expression in a Negative Autoregulatory Loop.
Checkpoint silencing during the DNA damage response in Caenorhabditis elegans embryos.
The T-box factor TBX-2 and the SUMO conjugating enzyme UBC-9 are required for ABa-derived pharyngeal muscle in C. elegans.
The shelterin protein POT-1 anchors Caenorhabditis elegans telomeres through SUN-1 at the nuclear periphery.
A common set of engulfment genes mediates removal of both apoptotic and necrotic cell corpses in C. elegans.
C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment.
CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration.
Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12.
Distinct rac activation pathways control Caenorhabditis elegans cell migration and axon outgrowth.
PH domain of ELMO functions in trans to regulate Rac activation via Dock180.
Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO.
The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway.
The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. elegans.
Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans.
Polycistronic expression and RNA-binding specificity of the C. elegans homologue of the spliceosome-associated protein SAP49.
A closed conformation of the Caenorhabditis elegans separase-securin complex.
Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution.
HECT-E3 ligase ETC-1 regulates securin and cyclin B1 cytoplasmic abundance to promote timely anaphase during meiosis in C. elegans.
The Caenorhabditis elegans distal-less ortholog ceh-43 is required for development of the anterior hypodermis.
The Caenorhabditis elegans F-box/WD-repeat protein lin-23 functions to limit cell division during development.
Active transport and diffusion barriers restrict Joubert syndrome-associated ARL13B/ARL-13 to an inv-like ciliary membrane subdomain.
Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in Caenorhabditis elegans.
SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors.
The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis.
A Caenorhabditis elegans wee1 homolog is expressed in a temporally and spatially restricted pattern during embryonic development.
SUMV-1 antagonizes the activity of synthetic multivulva genes in Caenorhabditis elegans.
Severe growth defect in a Schizosaccharomyces pombe mutant defective in intron lariat degradation.
The PAF1 complex is involved in embryonic epidermal morphogenesis in Caenorhabditis elegans.
Caenorhabditis elegans gelsolin-like protein 1 is a novel actin filament-severing protein with four gelsolin-like repeats.
Distinct roles of four gelsolin-like domains of Caenorhabditis elegans gelsolin-like protein-1 in actin filament severing, barbed end capping, and phosphoinositide binding.
Sugar transporters for intercellular exchange and nutrition of pathogens.
CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo.
CED-10/Rac1 mediates axon guidance by regulating the asymmetric distribution of MIG-10/lamellipodin.
Redundant canonical and noncanonical Caenorhabditis elegans p21-activated kinase signaling governs distal tip cell migrations.
The Caenorhabditis elegans P21-activated kinases are differentially required for UNC-6/netrin-mediated commissural motor axon guidance.
The Caenorhabditis elegans Ste20-related kinase and Rac-type small GTPase regulate the c-Jun N-terminal kinase signaling pathway mediating the stress response.
A measurable increase in oxidative damage due to reduction in superoxide detoxification fails to shorten the life span of long-lived mitochondrial mutants of Caenorhabditis elegans.
Activation of CuZn superoxide dismutases from Caenorhabditis elegans does not require the copper chaperone CCS.
Aging and resistance to oxidative damage in Caenorhabditis elegans.
MSP hormonal control of the oocyte MAP kinase cascade and reactive oxygen species signaling.
The copper/zinc superoxide dismutase gene of Caenorhabditis elegans.
Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1.
Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans.
lin-35/Rb and the CoREST ortholog spr-1 coordinately regulate vulval morphogenesis and gonad development in C. elegans.
Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference.
MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line.
6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33.
A new member of the ras superfamily, the rac1 homologue from Caenorhabditis elegans. Cloning and sequence analysis of cDNA, pattern of developmental expression, and biochemical characterization of the protein.
C. elegans PVF-1 inhibits permissive UNC-40 signalling through CED-10 GTPase to position the male ray 1 sensillum.
CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans.
Control of Growth Cone Polarity, Microtubule Accumulation, and Protrusion by UNC-6/Netrin and Its Receptors in Caenorhabditis elegans.
Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in Caenorhabditis elegans GABAergic neurotransmission.
The Caenorhabditis elegans p21-activated kinase (CePAK) colocalizes with CeRac1 and CDC42Ce at hypodermal cell boundaries during embryo elongation.
The UNC-6/Netrin receptors UNC-40/DCC and UNC-5 inhibit growth cone filopodial protrusion via UNC-73/Trio, Rac-like GTPases and UNC-33/CRMP.
VHA-19 is essential in Caenorhabditis elegans oocytes for embryogenesis and is involved in trafficking in oocytes.
A fibulin-1 homolog interacts with an ADAM protease that controls cell migration in C. elegans.
Fibulin-1C and Fibulin-1D splice variants have distinct functions and assemble in a hemicentin-dependent manner.
GON-1 and fibulin have antagonistic roles in control of organ shape.
Growth control by EGF repeats of the C. elegans Fibulin-1C isoform.
Identification of chicken and C. elegans fibulin-1 homologs and characterization of the C. elegans fibulin-1 gene.
MIG-17/ADAMTS controls cell migration by recruiting nidogen to the basement membrane in C. elegans.
Tissue architecture in the Caenorhabditis elegans gonad depends on interactions among fibulin-1, type IV collagen and the ADAMTS extracellular protease.
Caenorhabditis elegans has two genes encoding functional D-aspartate oxidases.
Comparative characterization of three D-aspartate oxidases and one D-amino acid oxidase from Caenorhabditis elegans.
Spatiotemporal localization of D-amino acid oxidase and D-aspartate oxidases during development in Caenorhabditis elegans.
C. elegans LIN-18 is a Ryk ortholog and functions in parallel to LIN-17/Frizzled in Wnt signaling.
C. elegans POP-1/TCF functions in a canonical Wnt pathway that controls cell migration and in a noncanonical Wnt pathway that controls cell polarity.
Cortical beta-catenin and APC regulate asymmetric nuclear beta-catenin localization during asymmetric cell division in C. elegans.
GRDN-1/Girdin regulates dendrite morphogenesis and cilium position in two specialized sensory neuron types in C. elegans.
Lineage-specific regulators couple cell lineage asymmetry to the transcription of the Caenorhabditis elegans POU gene unc-86 during neurogenesis.
Molecular pathways that influence human tau-induced pathology in Caenorhabditis elegans.
Opposing Wnt pathways orient cell polarity during organogenesis.
The C. elegans RUNX transcription factor RNT-1/MAB-2 is required for asymmetrical cell division of the T blast cell.
The C. elegans gene lin-44, which controls the polarity of certain asymmetric cell divisions, encodes a Wnt protein and acts cell nonautonomously.
The Caenorhabditis elegans gene lin-44 controls the polarity of asymmetric cell divisions.
The roles of EGF and Wnt signaling during patterning of the C. elegans Bgamma/delta Equivalence Group.
Wnt gradient formation requires retromer function in Wnt-producing cells.
Wnt signal from multiple tissues and lin-3/EGF signal from the gonad maintain vulval precursor cell competence in Caenorhabditis elegans.
Wnt signaling positions neuromuscular connectivity by inhibiting synapse formation in C. elegans.
Wnt signals and frizzled activity orient anterior-posterior axon outgrowth in C. elegans.
Wnt signals can function as positional cues in establishing cell polarity.
C. elegans STRADalpha and SAD cooperatively regulate neuronal polarity and synaptic organization.
Long lifespan in worms with long telomeric DNA.
cDNA cloning of a novel heterogeneous nuclear ribonucleoprotein gene homologue in Caenorhabditis elegans using hamster prion protein cDNA as a hybridisation probe.
Caenorhabditis elegans aristaless/Arx gene alr-1 restricts variable gene expression.
Separate transcriptionally regulated pathways specify distinct classes of sister dendrites in a nociceptive neuron.
mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans.
Expression of intron-containing C. elegans heat shock genes in mouse cells demonstrates divergence of 3' splice site recognition sequences between nematodes and vertebrates, and an inhibitory effect of heat shock on the mammalian splicing apparatus.
Interaction of structure-specific and promiscuous G-protein-coupled receptors mediates small-molecule signaling in Caenorhabditis elegans.
Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6.
Unique structural features of a novel class of small heat shock proteins.
Characterization and functional studies of a FYVE domain-containing phosphatase in C. elegans.
Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human.
Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans.
Regulation of cortical contractility and spindle positioning by the protein phosphatase 6 PPH-6 in one-cell stage C. elegans embryos.
C. elegans CUL-4 prevents rereplication by promoting the nuclear export of CDC-6 via a CKI-1-dependent pathway.
A stress-responsive system for mitochondrial protein degradation.
Caenorhabditis elegans atx-2 promotes germline proliferation and the oocyte fate.
Control of the proliferation versus meiotic development decision in the C. elegans germline through regulation of GLD-1 protein accumulation.
EGO-1, a putative RNA-directed RNA polymerase, promotes germline proliferation in parallel with GLP-1/notch signaling and regulates the spatial organization of nuclear pore complexes and germline P granules in Caenorhabditis elegans.
Genetic regulation of entry into meiosis in Caenorhabditis elegans.
Multi-pathway control of the proliferation versus meiotic development decision in the Caenorhabditis elegans germline.
The GLD-2 poly(A) polymerase activates gld-1 mRNA in the Caenorhabditis elegans germ line.
Tissue-specific modification of gld-2 mRNA in C. elegans: likely C-to-U editing.
A C. elegans gene encodes a protein homologous to mammalian calreticulin.
CRT-1/calreticulin and the E3 ligase EEL-1/HUWE1 control hemidesmosome maturation in C. elegans development.
Mutations in Caenorhabditis elegans neuroligin-like glit-1, the apoptosis pathway and the calcium chaperone crt-1 increase dopaminergic neurodegeneration after 6-OHDA treatment.
A non-canonical role for the C. elegans dosage compensation complex in growth and metabolic regulation downstream of TOR complex 2.
Early aspects of Caenorhabditis elegans sex determination and dosage compensation are regulated by a zinc-finger protein.
HLB-1 functions as a new regulator for the organization and function of neuromuscular junctions in nematode Caenorhabditis elegans.
Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.
The liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegans.
A C. elegans model of nicotine-dependent behavior: regulation by TRP-family channels.
Nicotine-motivated behavior in Caenorhabditis elegans requires the nicotinic acetylcholine receptor subunits acr-5 and acr-15.
The kinetically dominant assembly pathway for centrosomal asters in Caenorhabditis elegans is gamma-tubulin dependent.
Mitochondrial endonuclease G is important for apoptosis in C. elegans.
A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants.
Antioxidant enzymes and their role in phoxim and carbaryl stress in Caenorhabditis elegans.
Lack of peroxisomal catalase causes a progeric phenotype in Caenorhabditis elegans.
Metabotyping of Caenorhabditis elegans reveals latent phenotypes.
Molecular basis for antioxidant enzymes in mediating copper detoxification in the nematode Caenorhabditis elegans.
SDF-9, a protein tyrosine phosphatase-like molecule, regulates the L3/dauer developmental decision through hormonal signaling in C. elegans.
Caenorhabditis elegans receptors related to mammalian vascular endothelial growth factor receptors are expressed in neural cells.
An evolutionarily conserved PLC-PKD-TFEB pathway for host defense.
Concentration memory-dependent synaptic plasticity of a taste circuit regulates salt concentration chemotaxis in Caenorhabditis elegans.
Identification of PLC210, a Caenorhabditis elegans phospholipase C, as a putative effector of Ras.
Inositol 1,4,5-trisphosphate signaling regulates rhythmic contractile activity of myoepithelial sheath cells in Caenorhabditis elegans.
Phospholipase C-epsilon regulates epidermal morphogenesis in Caenorhabditis elegans.
Phospholipase Cepsilon regulates ovulation in Caenorhabditis elegans.
Allele-specific phenotype suggests a possible stimulatory activity of rcan-1 on calcineurin in Caenorhabditis elegans.
Autophagy genes mediate the effect of calcineurin on life span in C. elegans.
Calcineurin interacts with KIN-29, a Ser/Thr kinase, in Caenorhabditis elegans.
Calcineurin may regulate multiple endocytic processes in C. elegans.
Calcineurin regulates coelomocyte endocytosis via DYN-1 and CUP-4 in Caenorhabditis elegans.
Casein kinase II and calcineurin modulate TRPP function and ciliary localization.
Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB.
Negative regulation and gain control of sensory neurons by the C. elegans calcineurin TAX-6.
Opposing functions of calcineurin and CaMKII regulate G-protein signaling in egg-laying behavior of C.elegans.
Regulator of calcineurin (rcan-1) regulates thermotaxis behavior in Caenorhabditis elegans.
The Caenorhabditis elegans homologue of Down syndrome critical region 1, RCN-1, inhibits multiple functions of the phosphatase calcineurin.
C. elegans STAT cooperates with DAF-7/TGF-beta signaling to repress dauer formation.
Phosphorylation of RNA polymerase II is independent of P-TEFb in the C. elegans germline.
Molecular cloning and functional expression of a Caenorhabditis elegans aminopeptidase structurally related to mammalian leukotriene A4 hydrolases.
Metabotropic GABA signalling modulates longevity in C. elegans.
Optogenetic analysis of GABAB receptor signaling in Caenorhabditis elegans motor neurons.
Characterization of xnp-1, a Caenorhabditis elegans gene similar to the human XNP/ATR-X gene.
XNP-1/ATR-X acts with RB, HP1 and the NuRD complex during larval development in C. elegans.
lin-35/Rb and xnp-1/ATR-X function redundantly to control somatic gonad development in C. elegans.
LET-99 determines spindle position and is asymmetrically enriched in response to PAR polarity cues in C. elegans embryos.
MES-1, a protein required for unequal divisions of the germline in early C. elegans embryos, resembles receptor tyrosine kinases and is localized to the boundary between the germline and gut cells.
The let-99 gene is required for proper spindle orientation during cleavage of the C. elegans embryo.
Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans.
Identification of multiple Caenorhabditis elegans caspases and their potential roles in proteolytic cascades.
Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3.
Ce-emerin and LEM-2: essential roles in Caenorhabditis elegans development, muscle function, and mitosis.
Inner nuclear membrane protein LEM-2 is required for correct nuclear separation and morphology in C. elegans.
A C. elegans patched gene, ptc-1, functions in germ-line cytokinesis.
The C. elegans vitellogenin genes: short sequence repeats in the promoter regions and homology to the vertebrate genes.
The Caenorhabditis elegans vitellogenin gene family includes a gene encoding a distantly related protein.
Vitellogenin motifs conserved in nematodes and vertebrates.
Vitellogenin-6 is a major carbonylated protein in aged nematode, Caenorhabditis elegans.
Caenorhabditis elegans compensates for the difference in X chromosome dosage between the sexes by regulating transcript levels.
DPY-27: a chromosome condensation protein homolog that regulates C. elegans dosage compensation through association with the X chromosome.
Developmental dynamics of X-chromosome dosage compensation by the DCC and H4K20me1 in C. elegans.
H4K20me1 contributes to downregulation of X-linked genes for C. elegans dosage compensation.
Mitoguardin-2-mediated lipid transfer preserves mitochondrial morphology and lipid droplet formation.
A forkhead protein controls sexual identity of the C. elegans male somatic gonad.
Two suppressors of sel-12 encode C2H2 zinc-finger proteins that regulate presenilin transcription in Caenorhabditis elegans.
First identification of a phosphorylcholine-substituted protein from Caenorhabditis elegans: isolation and characterization of the aspartyl protease ASP-6.
C. elegans seu-1 encodes novel nuclear proteins that regulate responses to UNC-6/netrin guidance cues.
Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsally.
Netrin (UNC-6) mediates dendritic self-avoidance.
Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans.
The receptor protein tyrosine phosphatase CLR-1 is required for synaptic partner recognition.
UNC-40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues.
UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans.
mig-38, a novel gene that regulates distal tip cell turning during gonadogenesis in C. elegans hermaphrodites.
Caveolin-2 is required for apical lipid trafficking and suppresses basolateral recycling defects in the intestine of Caenorhabditis elegans.
Overexpression of caveolins in Caenorhabditis elegans induces changes in egg-laying and fecundity.
The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore.
The DEAD box helicase RDE-12 promotes amplification of RNAi in cytoplasmic foci in C. elegans.
The vasa homolog rde-12 engages target mRNA and multiple argonaute proteins to promote RNAi in C. elegans.
Alternative splicing in the Caenorhabditis elegans DNA topoisomerase I gene.
Sperm chromatin proteomics identifies evolutionarily conserved fertility factors.
cDNA cloning, expression, and chromosomal localization of Caenorhabditis elegans DNA topoisomerase I.
Human DJ-1 and its homologs are novel glyoxalases.
Extracellular architecture of the SYG-1/SYG-2 adhesion complex instructs synaptogenesis.
Functional and spatial analysis of C. elegans SYG-1 and SYG-2, orthologs of the Neph/nephrin cell adhesion module directing selective synaptogenesis.
Functional dissection of SYG-1 and SYG-2, cell adhesion molecules required for selective synaptogenesis in C. elegans.
Synaptic specificity is generated by the synaptic guidepost protein SYG-2 and its receptor, SYG-1.
A Caenorhabditis elegans homeobox gene expressed in the male tail, a link between pattern formation and sexual dimorphism?
Stage-specific isoforms of Ascaris suum complex. II: The fumarate reductase of the parasitic adult and the succinate dehydrogenase of free-living larvae share a common iron-sulfur subunit.
Cell cycle- and swelling-induced activation of a Caenorhabditis elegans ClC channel is mediated by CeGLC-7alpha/beta phosphatases.
Protective coupling of mitochondrial function and protein synthesis via the eIF2alpha kinase GCN-2.
Conserved gene regulatory module specifies lateral neural borders across bilaterians.
TLP-1 is an asymmetric cell fate determinant that responds to Wnt signals and controls male tail tip morphogenesis in C. elegans.
An unsuspected ecdysteroid/steroid phosphatase activity in the key T-cell regulator, Sts-1: surprising relationship to insect ecdysteroid phosphate phosphatase.
A glial K/Cl transporter controls neuronal receptive ending shape by chloride inhibition of an rGC.
Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans.
Regulation of response properties and operating range of the AFD thermosensory neurons by cGMP signaling.
A Caenorhabditis elegans MAP kinase kinase, MEK-1, is involved in stress responses.
Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways.
Integration of Caenorhabditis elegans MAPK pathways mediating immunity and stress resistance by MEK-1 MAPK kinase and VHP-1 MAPK phosphatase.
Role of the Caenorhabditis elegans Shc adaptor protein in the c-Jun N-terminal kinase signaling pathway.
Stress-induced germ cell apoptosis by a p53 independent pathway in Caenorhabditis elegans.
The Caenorhabditis elegans MAPK phosphatase VHP-1 mediates a novel JNK-like signaling pathway in stress response.
A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line.
Cyclin E and Cdk2 control GLD-1, the mitosis/meiosis decision, and germline stem cells in Caenorhabditis elegans.
Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment in vivo.
The identities of sym-2, sym-3 and sym-4, three genes that are synthetically lethal with mec-8 in Caenorhabditis elegans.
Dehydration-induced tps gene transcripts from an anhydrobiotic nematode contain novel spliced leaders and encode atypical GT-20 family proteins.
Antagonistic sensory cues generate gustatory plasticity in Caenorhabditis elegans.
Dopamine negatively modulates the NCA ion channels in C. elegans.
G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans.
Structural domains required for Caenorhabditis elegans G protein-coupled receptor kinase 2 (GRK-2) function in vivo.
Bt toxin resistance from loss of a putative carbohydrate-modifying enzyme.
cDNA sequence of a translational elongation factor Ts homologue from Caenorhabditis elegans: mitochondrial factor-specific features found in the nematode homologue peptide.
Functional genomic analysis of the ADP-ribosylation factor family of GTPases: phylogeny among diverse eukaryotes and function in C. elegans.
The C. elegans evl-20 gene is a homolog of the small GTPase ARL2 and regulates cytoskeleton dynamics during cytokinesis and morphogenesis.
An Argonaute transports siRNAs from the cytoplasm to the nucleus.
Small regulatory RNAs inhibit RNA polymerase II during the elongation phase of transcription.
Caenorhabditis elegans Chk2-like gene is essential for meiosis but dispensable for DNA repair.
Critical role of Caenorhabditis elegans homologs of cds1 (Chk2)-related kinases in meiotic recombination.
A reduction in intestinal cell pHi due to loss of the Caenorhabditis elegans Na+/H+ exchanger NHX-2 increases life span.
How the intestinal peptide transporter PEPT-1 contributes to an obesity phenotype in Caenorhabditits elegans.
Oscillatory transepithelial H(+) flux regulates a rhythmic behavior in C. elegans.
Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1.
The NHX family of Na+-H+ exchangers in Caenorhabditis elegans.
Collaboration within the M1 aminopeptidase family promotes reproductive success in Caenorhabditis elegans.
Sustained centrosome-cortical contact ensures robust polarization of the one-cell C. elegans embryo.
The Caenorhabditis elegans orthologue of mammalian puromycin-sensitive aminopeptidase has roles in embryogenesis and reproduction.
The PAM-1 aminopeptidase regulates centrosome positioning to ensure anterior-posterior axis specification in one-cell C. elegans embryos.
The puromycin-sensitive aminopeptidase PAM-1 is required for meiotic exit and anteroposterior polarity in the one-cell Caenorhabditis elegans embryo.
Analysis of the catalytic and binding residues of the diadenosine tetraphosphate pyrophosphohydrolase from Caenorhabditis elegans by site-directed mutagenesis.
Cloning, characterisation and crystallisation of a diadenosine 5',5''-P(1),P(4)-tetraphosphate pyrophosphohydrolase from Caenorhabditis elegans.
Crystallization of a complex of Caenorhabditis elegans diadenosine tetraphosphate hydrolase and a non-hydrolysable substrate analogue, AppCH2ppA.
The crystal structure of diadenosine tetraphosphate hydrolase from Caenorhabditis elegans in free and binary complex forms.
Resistance is non-futile: resistance to Cry5B in the nematode Caenorhabditis elegans.
Resistance to Bacillus thuringiensis toxin in Caenorhabditis elegans from loss of fucose.
Identification and characterization of Caenorhabditis elegans gamma-tubulin in dividing cells and differentiated tissues.
DYF-4 regulates patched-related/DAF-6-mediated sensory compartment formation in C. elegans.
Isolation and characterization of Caenorhabditis elegans DNA sequences homologous to the v-abl oncogene.
An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium.
Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system.
UNC119 is required for G protein trafficking in sensory neurons.
Identification and characterization of a new member of the gas3/PMP22 gene family in C. elegans.
Molecular cloning and functional co-expression of a Caenorhabditis elegans nicotinic acetylcholine receptor subunit (acr-2).
Release-dependent feedback inhibition by a presynaptically localized ligand-gated anion channel.
Genetic analysis of lysosomal trafficking in Caenorhabditis elegans.
Maintenance of neuronal laterality in Caenorhabditis elegans through MYST histone acetyltransferase complex components LSY-12, LSY-13 and LIN-49.
DJR-1.2 of Caenorhabditis elegans is induced by DAF-16 in the dauer state.
[FeFe]-hydrogenase-like gene is involved in the regulation of sensitivity to oxygen in yeast and nematode.
Cloning of Caenorhabditis U2AF65: an alternatively spliced RNA containing a novel exon.
The vacuolar H+ -ATPase mediates intracellular acidification required for neurodegeneration in C. elegans.
V-ATPase V1 sector is required for corpse clearance and neurotransmission in Caenorhabditis elegans.
The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function.
Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. elegans oocyte meiosis.
The conserved wobble uridine tRNA thiolase Ctu1-Ctu2 is required to maintain genome integrity.
A regulatory cascade of three homeobox genes, ceh-10, ttx-3 and ceh-23, controls cell fate specification of a defined interneuron class in C. elegans.
An interneuronal chemoreceptor required for olfactory imprinting in C. elegans.
Genomic cis-regulatory architecture and trans-acting regulators of a single interneuron-specific gene battery in C. elegans.
Linking asymmetric cell division to the terminal differentiation program of postmitotic neurons in C. elegans.
Regulation of interneuron function in the C. elegans thermoregulatory pathway by the ttx-3 LIM homeobox gene.
Regulation of longevity by genes required for the functions of AIY interneuron in nematode Caenorhabditis elegans.
Structural basis for recognition of 5'-phosphotyrosine adducts by Tdp2.
The Caenorhabditis elegans sel-1 gene, a negative regulator of lin-12 and glp-1, encodes a predicted extracellular protein.
Autophagy-mediated longevity is modulated by lipoprotein biogenesis.
The nucleotide sequence of a nematode vitellogenin gene.
Phagocytic receptor CED-1 initiates a signaling pathway for degrading engulfed apoptotic cells.
A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans.
Defective lipid metabolism associated with mutation in klf-2 and klf-3: important roles of essential dietary salts in fat storage.
Mutation in Caenorhabditis elegans Krueppel-like factor, KLF-3 results in fat accumulation and alters fatty acid composition.
Ce-Duox1/BLI-3 generated reactive oxygen species trigger protective SKN-1 activity via p38 MAPK signaling during infection in C. elegans.
Characterization of N-acyl phosphatidylethanolamine-specific phospholipase-D isoforms in the nematode Caenorhabditis elegans.
Neuropeptide secreted from a pacemaker activates neurons to control a rhythmic behavior.
Activation of EGL-47, a Galpha(o)-coupled receptor, inhibits function of hermaphrodite-specific motor neurons to regulate Caenorhabditis elegans egg-laying behavior.
Monomethyl branched-chain fatty acids play an essential role in Caenorhabditis elegans development.
Caenorhabditis elegans period homolog lin-42 regulates the timing of heterochronic miRNA expression.
LIN-42, the Caenorhabditis elegans PERIOD homolog, negatively regulates microRNA transcription.
LIN-42/PERIOD controls cyclical and developmental progression of C. elegans molts.
Novel heterochronic functions of the Caenorhabditis elegans period-related protein LIN-42.
The C. elegans developmental timing protein LIN-42 regulates diapause in response to environmental cues.
The Period protein homolog LIN-42 negatively regulates microRNA biogenesis in C. elegans.
Defective mitochondrial protein translocation precludes normal Caenorhabditis elegans development.
The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom.
Array-assisted characterization of a fucosyltransferase required for the biosynthesis of complex core modifications of nematode N-glycans.
Bisecting Galactose as a Feature of N-Glycans of Wild-type and Mutant Caenorhabditis elegans.
Comparisons of Caenorhabditis fucosyltransferase mutants reveal a multiplicity of isomeric N-Glycan structures.
The P-glycoprotein gene family of Caenorhabditis elegans. Cloning and characterization of genomic and complementary DNA sequences.
The expression of two P-glycoprotein (pgp) genes in transgenic Caenorhabditis elegans is confined to intestinal cells.
Histidine protects against zinc and nickel toxicity in Caenorhabditis elegans.
Identification and classification of genes that act antagonistically to let-60 Ras signaling in Caenorhabditis elegans vulval development.
The Caenorhabditis elegans locus lin-15, a negative regulator of a tyrosine kinase signaling pathway, encodes two different proteins.
The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development.
CFP-1 interacts with HDAC1/2 complexes in C. elegans development.
Extreme HOT regions are CpG-dense promoters in C. elegans and humans.
Global regulation of Hox gene expression in C. elegans by a SAM domain protein.
SUMO modification is required for in vivo Hox gene regulation by the Caenorhabditis elegans Polycomb group protein SOP-2.
The C. elegans Polycomb gene sop-2 encodes an RNA binding protein.
Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in Caenorhabditis elegans.
Defects in synaptic vesicle docking in unc-18 mutants.
Differential Regulation of Synaptic Vesicle Tethering and Docking by UNC-18 and TOM-1.
Expression, purification and characterization of recombinant C. Elegans UNC-18.
Functional properties of the unc-64 gene encoding a Caenorhabditis elegans syntaxin.
Genes required for cellular UNC-6/netrin localization in Caenorhabditis elegans.
PKC-2 phosphorylation of UNC-18 Ser322 in AFD neurons regulates temperature dependency of locomotion.
Rab-3 and unc-18 interactions in alcohol sensitivity are distinct from synaptic transmission.
Regulation of the UNC-18-Caenorhabditis elegans syntaxin complex by UNC-13.
Structure-function study of mammalian Munc18-1 and C. elegans UNC-18 implicates domain 3b in the regulation of exocytosis.
The C. elegans unc-18 gene encodes a protein expressed in motor neurons.
The synaptic protein UNC-18 is phosphorylated by protein kinase C.
The unc-18 gene encodes a novel protein affecting the kinetics of acetylcholine metabolism in the nematode Caenorhabditis elegans.
UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans.
UNC-18 modulates ethanol sensitivity in Caenorhabditis elegans.
UNC-18 promotes both the anterograde trafficking and synaptic function of syntaxin.
A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large.
C. elegans ATAD-3 is essential for mitochondrial activity and development.
Caenorhabditis elegans ATAD-3 modulates mitochondrial iron and heme homeostasis.
MICS-1 interacts with mitochondrial ATAD-3 and modulates lifespan in C. elegans.
The WD40-repeat proteins WDR-20 and WDR-48 bind and activate the deubiquitinating enzyme USP-46 to promote the abundance of the glutamate receptor GLR-1 in the ventral nerve cord of Caenorhabditis elegans.
Structural and biochemical characterization of CRN-5 and Rrp46: an exosome component participating in apoptotic DNA degradation.
A C. elegans homolog for the UV-hypersensitivity syndrome disease gene UVSSA.
Hydrogen sulfide is an endogenous regulator of aging in Caenorhabditis elegans.
Sulfurous gases as biological messengers and toxins: comparative genetics of their metabolism in model organisms.
Developmental genetics of secretory vesicle acidification during Caenorhabditis elegans spermatogenesis.
The Caenorhabditis elegans spe-5 gene is required for morphogenesis of a sperm-specific organelle and is associated with an inherent cold-sensitive phenotype.
Suppressor mutations identify amino acids in PAA-1/PR65 that facilitate regulatory RSA-1/B'' subunit targeting of PP2A to centrosomes in C. elegans.
High nucleotide divergence in developmental regulatory genes contrasts with the structural elements of olfactory pathways in caenorhabditis.
Structure and expression of the Caenorhabditis elegans protein kinase C2 gene. Origins and regulated expression of a family of Ca2+-activated protein kinase C isoforms.
C. elegans bicd-1, homolog of the Drosophila dynein accessory factor Bicaudal D, regulates the branching of PVD sensory neuron dendrites.
CYY-1/cyclin Y and CDK-5 differentially regulate synapse elimination and formation for rewiring neural circuits.
Cyclin-dependent kinase 5 regulates the polarized trafficking of neuropeptide-containing dense-core vesicles in Caenorhabditis elegans motor neurons.
Dynein light chain DLC-1 promotes localization and function of the PUF protein FBF-2 in germline progenitor cells.
Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans.
Genomic structure of a cytoplasmic dynein heavy chain gene from the nematode Caenorhabditis elegans.
Nuclei migrate through constricted spaces using microtubule motors and actin networks in C. elegans hypodermal cells.
Spindle assembly checkpoint proteins regulate and monitor meiotic synapsis in C. elegans.
Intergenerational Pathogen-Induced Diapause in Caenorhabditis elegans Is Modulated by mir-243.
Functional analysis of pyrimidine biosynthesis enzymes using the anticancer drug 5-fluorouracil in Caenorhabditis elegans.
A peroxiredoxin specifically expressed in two types of pharyngeal neurons is required for normal growth and egg production in Caenorhabditis elegans.
A peroxiredoxin, PRDX-2, is required for insulin secretion and insulin/IIS-dependent regulation of stress resistance and longevity.
A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance.
Do developmental temperatures affect redox level and lifespan in C. elegans through upregulation of peroxiredoxin?
Effects of oxidative stress on behavior, physiology, and the redox thiol proteome of Caenorhabditis elegans.
Is overoxidation of peroxiredoxin physiologically significant?
Light and hydrogen peroxide inhibit C. elegans Feeding through gustatory receptor orthologs and pharyngeal neurons.
Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2.
Gastrulation initiation in Caenorhabditis elegans requires the function of gad-1, which encodes a protein with WD repeats.
Caenorhabditis elegans POLQ-1 and HEL-308 function in two distinct DNA interstrand cross-link repair pathways.
Helicase Q promotes homology-driven DNA double-strand break repair and prevents tandem duplications.
A survey of expressed genes in Caenorhabditis elegans.
Polymerase recognition of synthetic oligodeoxyribonucleotides incorporating degenerate pyrimidine and purine bases.
Calcium-signalling via the neuron calcium sensor-1 regulates associative learning and memory in C.elegans.
Regulation of rhodopsin phosphorylation by a family of neuronal calcium sensors.
Crystal structure of the Golgi casein kinase.
A novel calmodulin-like gene from the nematode Caenorhabditis elegans.
Cohesin-interacting protein WAPL-1 regulates meiotic chromosome structure and cohesion by antagonizing specific cohesin complexes.
Acyl-CoA dehydrogenase drives heat adaptation by sequestering fatty acids.
Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans.
Nuclear hormone receptors: Ancient 9aaTAD and evolutionally gained NCoA activation pathways.
CHE-14, a protein with a sterol-sensing domain, is required for apical sorting in C. elegans ectodermal epithelial cells.
Evolutionary conservation of a GPCR-independent mechanism of trimeric G protein activation.
A Caenorhabditis elegans cDNA that encodes a product resembling the rat glutathione S-transferase P subunit.
ATP-binding cassette transporters are required for efficient RNA interference in Caenorhabditis elegans.
Caenorhabditis elegans ABCRNAi transporters interact genetically with rde-2 and mut-7.
A genome-wide RNAi screen for enhancers of par mutants reveals new contributors to early embryonic polarity in Caenorhabditis elegans.
Pseudocleavage is dispensable for polarity and development in C. elegans embryos.
RhoA activation during polarization and cytokinesis of the early Caenorhabditis elegans embryo is differentially dependent on NOP-1 and CYK-4.
Characterization of a novel serotonin receptor from Caenorhabditis elegans: cloning and expression of two splice variants.
Lipid droplet protein LID-1 mediates ATGL-1-dependent lipolysis during fasting in Caenorhabditis elegans.
C21orf5, a novel human chromosome 21 gene, has a Caenorhabditis elegans ortholog (pad-1) required for embryonic patterning.
The HLH-6 transcription factor regulates C. elegans pharyngeal gland development and function.
Identification of a novel chondroitin hydrolase in Caenorhabditis elegans.
MEX-5 and MEX-6 function to establish soma/germline asymmetry in early C. elegans embryos.
Gain-of-function mutations in the MEC-4 DEG/ENaC sensory mechanotransduction channel alter gating and drug blockade.
Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans.
MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation.
The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel.
Characterization of a novel D2-like dopamine receptor with a truncated splice variant and a D1-like dopamine receptor unique to invertebrates from Caenorhabditis elegans.
Dopamine receptors antagonistically regulate behavioral choice between conflicting alternatives in C. elegans.
Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegans.
DPY-30, a nuclear protein essential early in embryogenesis for Caenorhabditis elegans dosage compensation.
Synaptic vesicle fusion is modulated through feedback inhibition by dopamine auto-receptors.
GPA-9 is a novel regulator of innate immunity against Escherichia coli foods in adult Caenorhabditis elegans.
Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans.
Structural basis for the recruitment of glycogen synthase by glycogenin.
The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction.
The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development.
The adaptor protein soc-1/Gab1 modifies growth factor receptor output in Caenorhabditis elegans.
Identification of conserved pathways of DNA-damage response and radiation protection by genome-wide RNAi.
The atm-1 gene is required for genome stability in Caenorhabditis elegans.
The nucleotide excision repair pathway is required for UV-C-induced apoptosis in Caenorhabditis elegans.
Characterization of a novel C. elegans RGS protein with a C2 domain: evidence for direct association between C2 domain and Galphaq subunit.
Natural polymorphisms in C. elegans HECW-1 E3 ligase affect pathogen avoidance behaviour.
Tripeptidyl peptidase II promotes fat formation in a conserved fashion.
Identification of lipid droplet structure-like/resident proteins in Caenorhabditis elegans.
Lipidomic and proteomic analysis of Caenorhabditis elegans lipid droplets and identification of ACS-4 as a lipid droplet-associated protein.
Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval induction.
Repression of Wnt signaling by a Fer-type nonreceptor tyrosine kinase.
The C. elegans engrailed homolog ceh-16 regulates the self-renewal expansion division of stem cell-like seam cells.
The Caenorhabditis elegans APC-related gene apr-1 is required for epithelial cell migration and Hox gene expression.
The axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans.
The divergent Caenorhabditis elegans beta-catenin proteins BAR-1, WRM-1 and HMP-2 make distinct protein interactions but retain functional redundancy in vivo.
Evidence for physical and functional association between EMB-5 and LIN-12 in Caenorhabditis elegans.
emb-5, a gene required for the correct timing of gut precursor cell division during gastrulation in Caenorhabditis elegans, encodes a protein similar to the yeast nuclear protein SPT6.
The nuclear hormone receptor SEX-1 is an X-chromosome signal that determines nematode sex.
XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators.
xol-1 acts as an early switch in the C. elegans male/hermaphrodite decision.
xol-1: a gene that controls the male modes of both sex determination and X chromosome dosage compensation in C. elegans.
Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity.
A novel biochemical method to identify target genes of individual microRNAs: identification of a new Caenorhabditis elegans let-7 target.
A protein-protein interaction map of the Caenorhabditis elegans 26S proteasome.
A novel and conserved protein AHO-3 is required for thermotactic plasticity associated with feeding states in Caenorhabditis elegans.
Caenorhabditis elegans SMA-10/LRIG is a conserved transmembrane protein that enhances bone morphogenetic protein signaling.
Control of Cdc14 activity coordinates cell cycle and development in Caenorhabditis elegans.
The CDC-14 phosphatase controls developmental cell-cycle arrest in C. elegans.
DIM-1, a novel immunoglobulin superfamily protein in Caenorhabditis elegans, is necessary for maintaining bodywall muscle integrity.
Analysis of chitin synthase function in a plant parasitic nematode, Meloidogyne artiellia, using RNAi.
WNK kinases sense molecular crowding and rescue cell volume via phase separation.
A casein kinase 1 prevents expulsion of the oocyte meiotic spindle into a polar body by regulating cortical contractility.
Casein kinase 1 gamma regulates oxidative stress response via interacting with the NADPH dual oxidase complex.
Impaired processing of FLP and NLP peptides in carboxypeptidase E (EGL-21)-deficient Caenorhabditis elegans as analyzed by mass spectrometry.
Characterization of C. elegans RING finger protein 1, a binding partner of ubiquitin-conjugating enzyme 1.
Coupled Caspase and N-End Rule Ligase Activities Allow Recognition and Degradation of Pluripotency Factor LIN-28 during Non-Apoptotic Development.
The UBR-1 ubiquitin ligase regulates glutamate metabolism to generate coordinated motor pattern in Caenorhabditis elegans.
Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes.
The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans.
EMB-30: an APC4 homologue required for metaphase-to-anaphase transitions during meiosis and mitosis in Caenorhabditis elegans.
Effective RNA interference in cultured silkworm cells mediated by overexpression of Caenorhabditis elegans SID-1.
Enhanced neuronal RNAi in C. elegans using SID-1.
Export of RNA silencing from C. elegans tissues does not require the RNA channel SID-1.
Genes required for systemic RNA interference in Caenorhabditis elegans.
SID-1 is a dsRNA-selective dsRNA-gated channel.
SID-1 protein of Caenorhabditis elegans mediates uptake of dsRNA into Bombyx cells.
Systemic RNA interference deficiency-1 (SID-1) extracellular domain selectively binds long double-stranded RNA and is required for RNA transport by SID-1.
Systemic RNAi in C. elegans requires the putative transmembrane protein SID-1.
Systemic RNAi in Caenorhabditis elegans.
The SID-1 double-stranded RNA transporter is not selective for dsRNA length.
Transport of dsRNA into cells by the transmembrane protein SID-1.
Uptake of extracellular double-stranded RNA by SID-2.
Response of DBL-1/TGF-beta signaling-mediated neuron-intestine communication to nanopolystyrene in nematode Caenorhabditis elegans.
mab-31 and the TGF-beta pathway act in the ray lineage to pattern C. elegans male sensory rays.
Molecular characterization of a novel RhoGAP, RRC-1 of the nematode Caenorhabditis elegans.
Oxytocin/vasopressin-related peptides have an ancient role in reproductive behavior.
Vasopressin/oxytocin-related signaling regulates gustatory associative learning in C. elegans.
C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains.
Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors.
Genetic enhancers of sem-5 define components of the gonad-independent guidance mechanism controlling sex myoblast migration in Caenorhabditis elegans hermaphrodites.
Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains.
The bZIP Transcription Factor ZIP-11 Is Required for the Innate Immune Regulation in Caenorhabditis elegans.
A Caenorhabditis elegans homologue of hunchback is required for late stages of development but not early embryonic patterning.
A secreted complement control-related protein ensures acetylcholine receptor clustering.
Proteolytic processing of the extracellular scaffolding protein LEV-9 is required for clustering acetylcholine receptors.
Cloning and biochemical characterization of the cyclophilin homologues from the free-living nematode Caenorhabditis elegans.
hch-1, a gene required for normal hatching and normal migration of a neuroblast in C. elegans, encodes a protein related to TOLLOID and BMP-1.
Perilipin-related protein regulates lipid metabolism in C. elegans.
Identification, sequence and expression patterns of the Caenorhabditis elegans col-36 and col-40 collagen-encoding genes.
A Persistence Detector for Metabolic Network Rewiring in an Animal.
Expression pattern of the C. elegans p21-activated protein kinase, CePAK.
Myosin II regulation during C. elegans embryonic elongation: LET-502/ROCK, MRCK-1 and PAK-1, three kinases with different roles.
New genes that interact with lin-35 Rb to negatively regulate the let-60 ras pathway in Caenorhabditis elegans.
A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension.
A diacylglycerol kinase modulates long-term thermotactic behavioral plasticity in C. elegans.
Goalpha regulates olfactory adaptation by antagonizing Gqalpha-DAG signaling in Caenorhabditis elegans.
Strong selective pressure to use G:U to mark an RNA acceptor stem for alanine.
Mitochondrial SKN-1/Nrf mediates a conserved starvation response.
Silencing of ubiquinone biosynthesis genes extends life span in Caenorhabditis elegans.
The disease-associated formin INF2/EXC-6 organizes lumen and cell outgrowth during tubulogenesis by regulating F-actin and microtubule cytoskeletons.
Caenorhabditis elegans galectins LEC-1-LEC-11: structural features and sugar-binding properties.
CDK-5 regulates the abundance of GLR-1 glutamate receptors in the ventral cord of Caenorhabditis elegans.
A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans.
Expression of multiple UNC-13 proteins in the Caenorhabditis elegans nervous system.
The Caenorhabditis elegans unc-13 gene product is a phospholipid-dependent high-affinity phorbol ester receptor.
C. elegans slit acts in midline, dorsal-ventral, and anterior-posterior guidance via the SAX-3/Robo receptor.
EVA-1 functions as an UNC-40 Co-receptor to enhance attraction to the MADD-4 guidance cue in Caenorhabditis elegans.
Neuronal migrations and axon fasciculation are disrupted in ina-1 integrin mutants.
A PQM-1-Mediated Response Triggers Transcellular Chaperone Signaling and Regulates Organismal Proteostasis.
Author Correction: PQM-1 controls hypoxic survival via regulation of lipid metabolism.
CEH-60/PBX and UNC-62/MEIS Coordinate a Metabolic Switch that Supports Reproduction in C. elegans.
Identification of stress-responsive genes in Caenorhabditis elegans using RT-PCR differential display.
PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity.
PQM-1 controls hypoxic survival via regulation of lipid metabolism.
Biochemical Characterization of Caenorhabditis elegans Ferritins.
The C. elegans G-protein-coupled receptor SRA-13 inhibits RAS/MAPK signalling during olfaction and vulval development.
Caenorhabditis elegans neprilysin NEP-1: an effector of locomotion and pharyngeal pumping.
A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity.
DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity.
Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.
Insulin-like signaling negatively regulates muscle arm extension through DAF-12 in Caenorhabditis elegans.
Mutants of Caenorhabditis elegans that form dauer-like larvae.
ULP-2 SUMO Protease Regulates E-Cadherin Recruitment to Adherens Junctions.
VHA-8, the E subunit of V-ATPase, is essential for pH homeostasis and larval development in C. elegans.
Vacuolar-type H+-ATPase E subunit is required for embryogenesis and yolk transfer in Caenorhabditis elegans.
The nuclear ubiquitin ligase adaptor SPOP is a conserved regulator of C9orf72 dipeptide toxicity.
UNC-89 (obscurin) binds to MEL-26, a BTB-domain protein, and affects the function of MEI-1 (katanin) in striated muscle of Caenorhabditis elegans.
Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging.
SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension.
A cellular and regulatory map of the cholinergic nervous system of C. elegans.
A family of acetylcholine-gated chloride channel subunits in Caenorhabditis elegans.
Functional characterization of three G protein-coupled receptors for pigment dispersing factors in Caenorhabditis elegans.
PDF receptor signaling in Caenorhabditis elegans modulates locomotion and egg-laying.
Pigment-dispersing factor signaling in the circadian system of Caenorhabditis elegans.
KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegans.
MEI-1/katanin is required for translocation of the meiosis I spindle to the oocyte cortex in C elegans.
The CENP-F-like proteins HCP-1 and HCP-2 target CLASP to kinetochores to mediate chromosome segregation.
Neuronally expressed Ras-family GTPase Di-Ras modulates synaptic activity in Caenorhabditis elegans.
Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.
MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events.
Caspase-mediated activation of Caenorhabditis elegans CED-8 promotes apoptosis and phosphatidylserine externalization.
Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans.
The ced-8 gene controls the timing of programmed cell deaths in C. elegans.
Xk-Related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells.
Caenorhabditis elegans orthologs of the aryl hydrocarbon receptor and its heterodimerization partner the aryl hydrocarbon receptor nuclear translocator.
The AHR-1 aryl hydrocarbon receptor and its co-factor the AHA-1 aryl hydrocarbon receptor nuclear translocator specify GABAergic neuron cell fate in C. elegans.
The Caenorhabditis elegans AHR-1 transcription complex controls expression of soluble guanylate cyclase genes in the URX neurons and regulates aggregation behavior.
The Caenorhabditis elegans aryl hydrocarbon receptor, AHR-1, regulates neuronal development.
Caenorhabditis elegans ciliary protein NPHP-8, the homologue of human RPGRIP1L, is required for ciliogenesis and chemosensation.
MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis.
Novel ubiquitin-like ribosomal protein fusion genes from the nematodes Caenorhabditis elegans and Caenorhabditis briggsae.
Caenorhabditis elegans PIEZO channel coordinates multiple reproductive tissues to govern ovulation.
The structure of a conserved piezo channel domain reveals a topologically distinct beta sandwich fold.
Regulation of Caenorhabditis elegans degenerin proteins by a putative extracellular domain.
The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans.
A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans.
ATP-2 interacts with the PLAT domain of LOV-1 and is involved in Caenorhabditis elegans polycystin signaling.
Distinct protein domains regulate ciliary targeting and function of C. elegans PKD-2.
General and cell-type specific mechanisms target TRPP2/PKD-2 to cilia.
Polycystin-2 accelerates Ca2+ release from intracellular stores in Caenorhabditis elegans.
The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway.
The KLP-6 kinesin is required for male mating behaviors and polycystin localization in Caenorhabditis elegans.
Dystrobrevin- and dystrophin-like mutants display similar phenotypes in the nematode Caenorhabditis elegans.
Genetic evidence for a dystrophin-glycoprotein complex (DGC) in Caenorhabditis elegans.
In vitro interactions of Caenorhabditis elegans dystrophin with dystrobrevin and syntrophin.
Mutations in the Caenorhabditis elegans dystrophin-like gene dys-1 lead to hyperactivity and suggest a link with cholinergic transmission.
Neural integrity is maintained by dystrophin in C. elegans.
GPA-14, a Galpha(i) subunit mediates dopaminergic behavioral plasticity in C. elegans.
The Caenorhabditis elegans D2-like dopamine receptor DOP-2 physically interacts with GPA-14, a Galphai subunit.
Identification of a homeobox-containing gene located between lin-45 and unc-24 on chromosome IV in the nematode Caenorhabditis elegans.
The Caenorhabditis elegans homeobox gene ceh-19 is required for MC motorneuron function.
A putative cation channel and its novel regulator: cross-species conservation of effects on general anesthesia.
Distinct roles of transcription factors EGL-46 and DAF-19 in specifying the functionality of a polycystin-expressing sensory neuron necessary for C. elegans male vulva location behavior.
Inhibition of cell fate repressors secures the differentiation of the touch receptor neurons of Caenorhabditis elegans.
Inhibition of touch cell fate by egl-44 and egl-46 in C. elegans.
Axon injury triggers EFA-6 mediated destabilization of axonal microtubules via TACC and doublecortin like kinase.
Axon regeneration pathways identified by systematic genetic screening in C. elegans.
Caenorhabditis elegans EFA-6 limits microtubule growth at the cell cortex.
Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants.
Regulation of Gliogenesis by lin-32/Atoh1 in Caenorhabditis elegans.
ngn-1/neurogenin Activates Transcription of Multiple Terminal Selector Transcription Factors in the Caenorhabditis elegans Nervous System.
Caenorhabditis elegans lin-13, a member of the LIN-35 Rb class of genes involved in vulval development, encodes a protein with zinc fingers and an LXCXE motif.
The C. elegans HP1 homologue HPL-2 and the LIN-13 zinc finger protein form a complex implicated in vulval development.
The Caenorhabditis elegans HP1 family protein HPL-2 maintains ER homeostasis through the UPR and hormesis.
Protein phosphatase 4 is required for centrosome maturation in mitosis and sperm meiosis in C. elegans.
The rde-1 gene, RNA interference, and transposon silencing in C. elegans.
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.
Interaction between the C. elegans cell-death regulators CED-9 and CED-4.
Pax2/5/8 proteins promote cell survival in C. elegans.
Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma.
The C. elegans orthologue ceBNIP3 interacts with CED-9 and CED-3 but kills through a BH3- and caspase-independent mechanism.
Unique structural features of a BCL-2 family protein CED-9 and biophysical characterization of CED-9/EGL-1 interactions.
The Caenorhabditis elegans paxillin orthologue, PXL-1, is required for pharyngeal muscle contraction and for viability.
A cGMP-dependent protein kinase is implicated in wild-type motility in C. elegans.
A novel gain-of-function mutant of the cyclic GMP-dependent protein kinase egl-4 affects multiple physiological processes in Caenorhabditis elegans.
Changes in cGMP levels affect the localization of EGL-4 in AWC in Caenorhabditis elegans.
Cyclic GMP-dependent protein kinase EGL-4 controls body size and lifespan in C elegans.
Nuclear PKG localization is regulated by G(0) alpha and is necessary in the AWB neurons to mediate avoidance in Caenorhabditis elegans.
Nuclear entry of a cGMP-dependent kinase converts transient into long-lasting olfactory adaptation.
Parallel encoding of sensory history and behavioral preference during Caenorhabditis elegans olfactory learning.
The cyclic GMP-dependent protein kinase EGL-4 regulates olfactory adaptation in C. elegans.
The receptor-bound guanylyl cyclase DAF-11 is the mediator of hydrogen peroxide-induced cGMP increase in Caenorhabditis elegans.
cGMP and a germ-line signal control body size in C. elegans through cGMP-dependent protein kinase EGL-4.
egl-4 acts through a transforming growth factor-beta/SMAD pathway in Caenorhabditis elegans to regulate multiple neuronal circuits in response to sensory cues.
A deubiquitinating enzyme, UCH/CeUBP130, has an essential role in the formation of a functional microtubule-organizing centre (MTOC) during early cleavage in C. elegans.
A ubiquitin C-terminal hydrolase is required to maintain osmotic balance and execute actin-dependent processes in the early C. elegans embryo.
USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction.
REI-1 is a guanine nucleotide exchange factor regulating RAB-11 localization and function in C. elegans embryos.
A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans.
Heterochronic genes control cell cycle progress and developmental competence of C. elegans vulva precursor cells.
Heterochronic genes control the stage-specific initiation and expression of the dauer larva developmental program in Caenorhabditis elegans.
Heterochronic mutants of the nematode Caenorhabditis elegans.
Identification of heterochronic mutants in Caenorhabditis elegans. Temporal misexpression of a collagen::green fluorescent protein fusion gene.
Regulation of signaling genes by TGFbeta during entry into dauer diapause in C. elegans.
Reversal of cell fate determination in Caenorhabditis elegans vulval development.
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans.
The C. elegans heterochronic gene lin-46 affects developmental timing at two larval stages and encodes a relative of the scaffolding protein gephyrin.
The Caenorhabditis elegans heterochronic gene pathway controls stage-specific transcription of collagen genes.
The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA.
The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans.
The time of appearance of the C. elegans let-7 microRNA is transcriptionally controlled utilizing a temporal regulatory element in its promoter.
Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation.
daf-12 regulates developmental age and the dauer alternative in Caenorhabditis elegans.
Alterations in ribosome biogenesis cause specific defects in C. elegans hermaphrodite gonadogenesis.
C. elegans pro-1 activity is required for soma/germline interactions that influence proliferation and differentiation in the germ line.
Isolation and in situ localization of a cDNA encoding a Kex2-like prohormone convertase in the nematode Caenorhabditis elegans.
The EGL-21 carboxypeptidase E facilitates acetylcholine release at Caenorhabditis elegans neuromuscular junctions.
The EGL-3 proprotein convertase regulates mechanosensory responses of Caenorhabditis elegans.
A network of HSPG core proteins and HS modifying enzymes regulates netrin-dependent guidance of D-type motor neurons in Caenorhabditis elegans.
Endocannabinoid-Goalpha signalling inhibits axon regeneration in Caenorhabditis elegans by antagonizing Gqalpha-PKC-JNK signalling.
The growth factor SVH-1 regulates axon regeneration in C. elegans via the JNK MAPK cascade.
Isolation of AF2 (KHEYLRFamide) from Caenorhabditis elegans: evidence for the presence of more than one FMRFamide-related peptide-encoding gene.
Neuroendocrine modulation sustains the C. elegans forward motor state.
Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development.
kin-18, a C. elegans protein kinase involved in feeding.
MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome.
Sphingosine phosphate lyase expression is essential for normal development in Caenorhabditis elegans.
Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1.
Ce-Y14 and MAG-1, components of the exon-exon junction complex, are required for embryogenesis and germline sexual switching in Caenorhabditis elegans.
Mago nashi mediates the posterior follicle cell-to-oocyte signal to organize axis formation in Drosophila.
Slow co-evolution of the MAGO and Y14 protein families is required for the maintenance of their obligate heterodimerization mode.
mag-1, a homolog of Drosophila mago nashi, regulates hermaphrodite germ-line sex determination in Caenorhabditis elegans.
Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation.
Identification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase.
C. elegans meg-1 and meg-2 differentially interact with nanos family members to either promote or inhibit germ cell proliferation and survival.
MEG-1 and MEG-2 are embryo-specific P-granule components required for germline development in Caenorhabditis elegans.
Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans.
An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay.
Basolateral localization of the Caenorhabditis elegans epidermal growth factor receptor in epithelial cells by the PDZ protein lin-10.
An RNA 5'-triphosphatase related to the protein tyrosine phosphatases.
A left/right asymmetric neuronal differentiation program is controlled by the Caenorhabditis elegans lsy-27 zinc-finger transcription factor.
Structural basis for the antagonistic roles of RNP-8 and GLD-3 in GLD-2 poly(A)-polymerase activity.
lin-31, a Caenorhabditis elegans HNF-3/fork head transcription factor homolog, specifies three alternative cell fates in vulval development.
Caenorhabditis elegans VEM-1, a novel membrane protein, regulates the guidance of ventral nerve cord-associated axons.
Multiple isoforms of eukaryotic protein synthesis initiation factor 4E in Caenorhabditis elegans can distinguish between mono- and trimethylated mRNA cap structures.
Caenorhabditis elegans calnexin is N-glycosylated and required for stress response.
Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca(2+) release from the endoplasmic reticulum.
Molecular characterization of an anchor protein (AKAPCE) that binds the RI subunit (RCE) of type I protein kinase A from Caenorhabditis elegans.
The C. elegans homolog of Drosophila Lethal giant larvae functions redundantly with PAR-2 to maintain polarity in the early embryo.
A Conserved role for girdin in basal body positioning and ciliogenesis.
Mutant sensory cilia in the nematode Caenorhabditis elegans.
Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles.
Striated rootlet and nonfilamentous forms of rootletin maintain ciliary function.
Caenorhabditis elegans contains genes encoding two new members of the Zn-containing alcohol dehydrogenase family.
A histone-H3-like protein in C. elegans.
Characterization of HCP-6, a C. elegans protein required to prevent chromosome twisting and merotelic attachment.
HCP-4/CENP-C promotes the prophase timing of centromere resolution by enabling the centromere association of HCP-6 in Caenorhabditis elegans.
MEL-28 is downstream of the Ran cycle and is required for nuclear-envelope function and chromatin maintenance.
C. elegans ZAG-1, a Zn-finger-homeodomain protein, regulates axonal development and neuronal differentiation.
Regulation of C. elegans neuronal differentiation by the ZEB-family factor ZAG-1 and the NK-2 homeodomain factor CEH-28.
zag-1, a Zn-finger homeodomain transcription factor controlling neuronal differentiation and axon outgrowth in C. elegans.
iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human.
Feeding status and serotonin rapidly and reversibly modulate a Caenorhabditis elegans chemosensory circuit.
Reverse genetics by chemical mutagenesis in Caenorhabditis elegans.
Behavioral and synaptic defects in C. elegans lacking the NK-2 homeobox gene ceh-28.
CEH-28 activates dbl-1 expression and TGF-beta signaling in the C. elegans M4 neuron.
A novel member of the GCN5-related N-acetyltransferase superfamily from Caenorhabditis elegans preferentially catalyses the N-acetylation of thialysine [S-(2-aminoethyl)-L-cysteine].
NuRD mediates mitochondrial stress-induced longevity via chromatin remodeling in response to acetyl-CoA level.
C. elegans screen identifies autophagy genes specific to multicellular organisms.
The C. elegans LC3 acts downstream of GABARAP to degrade autophagosomes by interacting with the HOPS subunit VPS39.
Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi.
Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in the ERGO-1/Argonaute pathway.
The Caenorhabditis elegans HEN1 ortholog, HENN-1, methylates and stabilizes select subclasses of germline small RNAs.
The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications.
JAMP optimizes ERAD to protect cells from unfolded proteins.
Identity of the F52F12.1 gene product in Caenorhabditis elegans as an organic cation transporter.
Molecular analysis of Caenorhabditis elegans tcp-1, a gene encoding a chaperonin protein.
A BMP homolog acts as a dose-dependent regulator of body size and male tail patterning in Caenorhabditis elegans.
Caenorhabditis elegans DBL-1/BMP Regulates Lipid Accumulation via Interaction with Insulin Signaling.
DBL-1, a TGF-beta, is essential for Caenorhabditis elegans aversive olfactory learning.
Non-stringent tissue-source requirements for BMP ligand expression in regulation of body size in Caenorhabditis elegans.
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
Deficiency of alpha-glucosidase I alters glycoprotein glycosylation and lifespan in Caenorhabditis elegans.
Identification of a cysteine residue important for the ATPase activity of C. elegans fidgetin homologue.
Mutational analysis of the functional motifs in the ATPase domain of Caenorhabditis elegans fidgetin homologue FIGL-1: firm evidence for an intersubunit catalysis mechanism of ATP hydrolysis by AAA ATPases.
The AAA-ATPase FIGL-1 controls mitotic progression, and its levels are regulated by the CUL-3MEL-26 E3 ligase in the C. elegans germ line.
The ribonucleotidyl transferase USIP-1 acts with SART3 to promote U6 snRNA recycling.
Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins.
Correction: Serum- and Glucocorticoid-Inducible Kinase-1 (SGK-1) Plays a Role in Membrane Trafficking in Caenorhabditis elegans.
Mutations affecting symmetrical migration of distal tip cells in Caenorhabditis elegans.
Regulation of endosomal clathrin and retromer-mediated endosome to Golgi retrograde transport by the J-domain protein RME-8.
Serum- and Glucocorticoid-Inducible Kinase-1 (SGK-1) Plays a Role in Membrane Trafficking in Caenorhabditis elegans.
Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells.
Simultaneous ablation of prmt-1 and prmt-5 abolishes asymmetric and symmetric arginine dimethylations in Caenorhabditis elegans.
Structural insights into protein arginine symmetric dimethylation by PRMT5.
Substrate specificity, processivity, and kinetic mechanism of protein arginine methyltransferase 5.
Coelomocytes Regulate Starvation-Induced Fat Catabolism and Lifespan Extension through the Lipase LIPL-5 in Caenorhabditis elegans.
Lipase-like 5 enzyme controls mitochondrial activity in response to starvation in Caenorhabditis elegans.
Analysis of NPR-1 reveals a circuit mechanism for behavioral quiescence in C. elegans.
Differential activation of 'social' and 'solitary' variants of the Caenorhabditis elegans G protein-coupled receptor NPR-1 by its cognate ligand AF9.
Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation of NPR-1.
The laboratory domestication of Caenorhabditis elegans.
Protein phosphatase 5 is a negative regulator of separase function during cortical granule exocytosis in C. elegans.
Separase is required for chromosome segregation during meiosis I in Caenorhabditis elegans.
Genetic analysis of the spindle checkpoint genes san-1, mdf-2, bub-3 and the CENP-F homologues hcp-1 and hcp-2 in Caenorhabditis elegans.
ERG-28 controls BK channel trafficking in the ER to regulate synaptic function and alcohol response in C. elegans.
A new kind of informational suppression in the nematode Caenorhabditis elegans.
SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans.
LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans.
Molecular cloning of a splice variant of Caenorhabditis elegans YNK1, a putative element in signal transduction.
PDF-1 neuropeptide signaling modulates a neural circuit for mate-searching behavior in C. elegans.
Serotonin and the neuropeptide PDF initiate and extend opposing behavioral states in C. elegans.
An RNA-Binding Multimer Specifies Nematode Sperm Fate.
The fog-3 gene and regulation of cell fate in the germ line of Caenorhabditis elegans.
The Caenorhabditis elegans rhy-1 gene inhibits HIF-1 hypoxia-inducible factor activity in a negative feedback loop that does not include vhl-1.
RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in Caenorhabditis elegans.
ANK repeat-domain of SHN-1 is indispensable for in vivo SHN-1 function in C. elegans.
SHN-1, a Shank homologue in C. elegans, affects defecation rhythm via the inositol-1,4,5-trisphosphate receptor.
Shank is a dose-dependent regulator of Cav1 calcium current and CREB target expression.
Promotion of bone morphogenetic protein signaling by tetraspanins and glycosphingolipids.
Tetraspanins TSP-12 and TSP-14 function redundantly to regulate the trafficking of the type II BMP receptor in Caenorhabditis elegans.
The C. elegans TspanC8 tetraspanin TSP-14 exhibits isoform-specific localization and function.
The C. elegans gon-2 gene encodes a putative TRP cation channel protein required for mitotic cell cycle progression.
gon-2, a gene required for gonadogenesis in Caenorhabditis elegans.
Involvement of HMG-12 and CAR-1 in the cdc-48.1 expression of Caenorhabditis elegans.
Unique and redundant functions of SR proteins, a conserved family of splicing factors, in Caenorhabditis elegans development.
A role for C. elegans Eph RTK signaling in PTEN regulation.
An Eph receptor sperm-sensing control mechanism for oocyte meiotic maturation in Caenorhabditis elegans.
The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. elegans.
A portable regulatory element directs specific expression of the Caenorhabditis elegans ubiquitin gene ubq-2 in the somatic gonad.
An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators.
Structural genomics of Caenorhabditis elegans: structure of the BAG domain.
Structural and functional characteristics of two sodium-coupled dicarboxylate transporters (ceNaDC1 and ceNaDC2) from Caenorhabditis elegans and their relevance to life span.
Developmental arrest of Caenorhabditis elegans BRAP-2 mutant exposed to oxidative stress is dependent on BRC-1.
Functional assessment of Nramp-like metal transporters and manganese in Caenorhabditis elegans.
SMF-1, SMF-2 and SMF-3 DMT1 orthologues regulate and are regulated differentially by manganese levels in C. elegans.
The divalent metal transporter homologues SMF-1/2 mediate dopamine neuron sensitivity in caenorhabditis elegans models of manganism and parkinson disease.
A component of the transcriptional mediator complex inhibits RAS-dependent vulval fate specification in C. elegans.
C. elegans SoxB genes are dispensable for embryonic neurogenesis but required for terminal differentiation of specific neuron types.
Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans.
Carboxy-terminal truncation activates glp-1 protein to specify vulval fates in Caenorhabditis elegans.
Control of cell fate in C. elegans by a GLP-1 peptide consisting primarily of ankyrin repeats.
Small nucleoli are a cellular hallmark of longevity.
The canonical Notch signaling pathway: unfolding the activation mechanism.
glp-1 and lin-12, genes implicated in distinct cell-cell interactions in C. elegans, encode similar transmembrane proteins.
lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans.
An autosomal gene that affects X chromosome expression and sex determination in Caenorhabditis elegans.
Dynamic Control of X Chromosome Conformation and Repression by a Histone H4K20 Demethylase.
Molecular analysis of X chromosome dosage compensation in Caenorhabditis elegans.
The neurexin superfamily of Caenorhabditis elegans.
The C. elegans SNAPc component SNPC-4 coats piRNA domains and is globally required for piRNA abundance.
An ER-resident membrane protein complex regulates nicotinic acetylcholine receptor subunit composition at the synapse.
OLA-1, an Obg-like ATPase, integrates hunger with temperature information in sensory neurons in C. elegans.
An SLC6 transporter of the novel B(0,)- system aids in absorption and detection of nutrient amino acids in Caenorhabditis elegans.
The Reproduction Rate of Peptide Transporter PEPT-1 Deficient C. elegans Is Dependent on Dietary Glutamate Supply.
A fork head/HNF-3 homolog expressed in the pharynx and intestine of the Caenorhabditis elegans embryo.
An early pharyngeal muscle enhancer from the Caenorhabditis elegans ceh-22 gene is targeted by the forkhead factor PHA-4.
Contribution of the amino and carboxyl termini for PHA-4/FoxA function in Caenorhabditis elegans.
Gland-specific expression of C. elegans hlh-6 requires the combinatorial action of three distinct promoter elements.
PHA-4/FoxA cooperates with TAM-1/TRIM to regulate cell fate restriction in the C. elegans foregut.
PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans.
Regulation of organogenesis by the Caenorhabditis elegans FoxA protein PHA-4.
Role of T-box gene tbx-2 for anterior foregut muscle development in C. elegans.
Temporal regulation of foregut development by HTZ-1/H2A.Z and PHA-4/FoxA.
The pha-4 gene is required to generate the pharyngeal primordium of Caenorhabditis elegans.
The temporal patterning microRNA let-7 regulates several transcription factors at the larval to adult transition in C. elegans.
pha-4 is Ce-fkh-1, a fork head/HNF-3alpha,beta,gamma homolog that functions in organogenesis of the C. elegans pharynx.
pha-4, an HNF-3 homolog, specifies pharyngeal organ identity in Caenorhabditis elegans.
A conserved PTEN/FOXO pathway regulates neuronal morphology during C. elegans development.
C. elegans DAF-18/PTEN mediates nutrient-dependent arrest of cell cycle and growth in the germline.
DAF-18/PTEN locally antagonizes insulin signalling to couple germline stem cell proliferation to oocyte needs in C. elegans.
Doxycyclin ameliorates a starvation-induced germline tumor in C. elegans daf-18/PTEN mutant background.
Genetic redundancy masks diverse functions of the tumor suppressor gene PTEN during C. elegans development.
Insulin activates the insulin receptor to downregulate the PTEN tumour suppressor.
PTEN negatively regulates MAPK signaling during Caenorhabditis elegans vulval development.
Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN.
Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene.
The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway.
The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway.
The human tumour suppressor PTEN regulates longevity and dauer formation in Caenorhabditis elegans.
A global profile of germline gene expression in C. elegans.
Identification of in vivo mRNA targets of GLD-1, a maxi-KH motif containing protein required for C. elegans germ cell development.
The eggshell is required for meiotic fidelity, polar-body extrusion and polarization of the C. elegans embryo.
Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-11.
The LIM region of a presumptive Caenorhabditis elegans transcription factor is an iron-sulfur- and zinc-containing metallodomain.
The small ubiquitin-like modifier (SUMO) is required for gonadal and uterine-vulval morphogenesis in Caenorhabditis elegans.
Unconventional function of an Achaete-Scute homolog as a terminal selector of nociceptive neuron identity.
The novel secreted factor MIG-18 acts with MIG-17/ADAMTS to control cell migration in Caenorhabditis elegans.
Sleep-active neuron specification and sleep induction require FLP-11 neuropeptides to systemically induce sleep.
The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons.
The homeobox gene lim-6 is required for distinct chemosensory representations in C. elegans.
Developmental defects of Caenorhabditis elegans lacking branched-chain alpha-ketoacid dehydrogenase are mainly caused by monomethyl branched-chain fatty acid deficiency.
The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments.
LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis.
The gene defective in leukocyte adhesion deficiency II encodes a putative GDP-fucose transporter.
glo-3, a novel Caenorhabditis elegans gene, is required for lysosome-related organelle biogenesis.
An innexin-dependent cell network establishes left-right neuronal asymmetry in C. elegans.
The conserved LIM domain-containing focal adhesion protein ZYX-1 regulates synapse maintenance in Caenorhabditis elegans.
ZYX-1, the unique zyxin protein of Caenorhabditis elegans, is involved in dystrophin-dependent muscle degeneration.
Splice site m6A methylation prevents binding of U2AF35 to inhibit RNA splicing.
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7.
Probiotic Lactobacillus fermentum strain JDFM216 stimulates the longevity and immune response of Caenorhabditis elegans through a nuclear hormone receptor.
The Caenorhabditis elegans nuclear receptor gene nhr-25 regulates epidermal cell development.
nhr-25, the Caenorhabditis elegans ortholog of ftz-f1, is required for epidermal and somatic gonad development.
NRFL-1, the C. elegans NHERF orthologue, interacts with amino acid transporter 6 (AAT-6) for age-dependent maintenance of AAT-6 on the membrane.
A role for WDR5 in TRA-1/Gli mediated transcriptional control of the sperm/oocyte switch in C. elegans.
Direct protein-protein interaction between the intracellular domain of TRA-2 and the transcription factor TRA-1A modulates feminizing activity in C. elegans.
Molecular analysis of the C. elegans sex-determining gene tra-1: a gene encoding two zinc finger proteins.
RNA-Regulated TRA-1 nuclear export controls sexual fate.
The TRA-1 transcription factor binds TRA-2 to regulate sexual fates in Caenorhabditis elegans.
Zinc fingers in sex determination: only one of the two C. elegans Tra-1 proteins binds DNA in vitro.
LIN-5 is a novel component of the spindle apparatus required for chromosome segregation and cleavage plane specification in Caenorhabditis elegans.
Co-expression of the transcription factors CEH-14 and TTX-1 regulates AFD neuron-specific genes gcy-8 and gcy-18 in C. elegans.
Specification of thermosensory neuron fate in C. elegans requires ttx-1, a homolog of otd/Otx.
C. elegans Punctin Clusters GABA(A) Receptors via Neuroligin Binding and UNC-40/DCC Recruitment.
C. elegans Punctin specifies cholinergic versus GABAergic identity of postsynaptic domains.
MADD-4 is a secreted cue required for midline-oriented guidance in Caenorhabditis elegans.
MADD-4/Punctin and Neurexin Organize C. elegans GABAergic Postsynapses through Neuroligin.
Caenorhabditis elegans has two isozymic forms, CE-1 and CE-2, of fructose-1,6-bisphosphate aldolase which are encoded by different genes.
Insights into the structure and RNA-binding specificity of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3).
Genetics: influence of TOR kinase on lifespan in C. elegans.
Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans.
TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation.
Cellular and subcellular localization, N-terminal acylation, and calcium binding of Caenorhabditis elegans protein phosphatase with EF-hands.
Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C.
A Cold-Sensing Receptor Encoded by a Glutamate Receptor Gene.
Wnt signaling drives WRM-1/beta-catenin asymmetries in early C. elegans embryos.
REST and stress resistance in ageing and Alzheimer's disease.
Baculovirus expression of two protein disulphide isomerase isoforms from Caenorhabditis elegans and characterization of prolyl 4-hydroxylases containing one of these polypeptides as their beta subunit.
Prolyl 4-hydroxylase is an essential procollagen-modifying enzyme required for exoskeleton formation and the maintenance of body shape in the nematode Caenorhabditis elegans.
The exoskeleton collagens in Caenorhabditis elegans are modified by prolyl 4-hydroxylases with unique combinations of subunits.
Genomic structure and expression of the mouse growth factor receptor related to tyrosine kinases (Ryk).
lin-17/Frizzled and lin-18 regulate POP-1/TCF-1 localization and cell type specification during C. elegans vulval development.
Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline.
ZNFX-1 Functions within Perinuclear Nuage to Balance Epigenetic Signals.
Cytosolic aconitase and ferritin are regulated by iron in Caenorhabditis elegans.
MIG-32 and SPAT-3A are PRC1 homologs that control neuronal migration in Caenorhabditis elegans.
A forward genetic screen for suppressors of somatic P granules in Caenorhabditis elegans.
A mechanistic basis for the coordinated regulation of pharyngeal morphogenesis in Caenorhabditis elegans by LIN-35/Rb and UBC-18-ARI-1.
A network of genes antagonistic to the LIN-35 retinoblastoma protein of Caenorhabditis elegans.
C. elegans HIM-17 links chromatin modification and competence for initiation of meiotic recombination.
C. elegans class B synthetic multivulva genes act in G(1) regulation.
C. elegans orthologs of components of the RB tumor suppressor complex have distinct pro-apoptotic functions.
Coordinated regulation of intestinal functions in C. elegans by LIN-35/Rb and SLR-2.
Implicating SCF complexes in organogenesis in Caenorhabditis elegans.
LIN-35/Rb causes starvation-induced germ cell apoptosis via CED-9/Bcl2 downregulation in Caenorhabditis elegans.
Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genes.
Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cells.
The coordinate regulation of pharyngeal development in C. elegans by lin-35/Rb, pha-1, and ubc-18.
The lin-35/Rb and RNAi pathways cooperate to regulate a key cell cycle transition in C. elegans.
The tumor suppressor Rb critically regulates starvation-induced stress response in C. elegans.
Tissue-specific direct targets of Caenorhabditis elegans Rb/E2F dictate distinct somatic and germline programs.
fzr-1 and lin-35/Rb function redundantly to control cell proliferation in C. elegans as revealed by a nonbiased synthetic screen.
lin-35 Rb acts in the major hypodermis to oppose ras-mediated vulval induction in C. elegans.
lin-35 Rb and cki-1 Cip/Kip cooperate in developmental regulation of G1 progression in C. elegans.
lin-35/Rb and ubc-18, an E2 ubiquitin-conjugating enzyme, function redundantly to control pharyngeal morphogenesis in C. elegans.
lin-35/Rb cooperates with the SWI/SNF complex to control Caenorhabditis elegans larval development.
The Caenorhabditis elegans Y87G2A.14 Nudix hydrolase is a peroxisomal coenzyme A diphosphatase.
Cloning, sequencing and mapping of a manganese superoxide dismutase gene of the nematode Caenorhabditis elegans.
Kinesin-1 and dynein at the nuclear envelope mediate the bidirectional migrations of nuclei.
Multiple mechanisms actively target the SUN protein UNC-84 to the inner nuclear membrane.
The SUN protein UNC-84 is required only in force-bearing cells to maintain nuclear envelope architecture.
UNC-83 IS a KASH protein required for nuclear migration and is recruited to the outer nuclear membrane by a physical interaction with the SUN protein UNC-84.
UNC-83 is a nuclear-specific cargo adaptor for kinesin-1-mediated nuclear migration.
unc-83 encodes a novel component of the nuclear envelope and is essential for proper nuclear migration.
Identification and characterization of the high-affinity choline transporter.
Negative regulation of male development in Caenorhabditis elegans by a protein-protein interaction between TRA-2A and FEM-3.
Rapid coevolution of the nematode sex-determining genes fem-3 and tra-2.
Structural insight into Caenorhabditis elegans sex-determining protein FEM-2.
The Caenorhabditis elegans sex determining gene fem-3 is regulated post-transcriptionally.
Mechanosensory signalling in C. elegans mediated by the GLR-1 glutamate receptor.
NPR-9, a galanin-like G-protein coupled receptor, and GLR-1 regulate interneuronal circuitry underlying multisensory integration of environmental cues in Caenorhabditis elegans.
SOL-1 is a CUB-domain protein required for GLR-1 glutamate receptor function in C. elegans.
Ubiquitin and AP180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in C. elegans.
A novel molecular solution for ultraviolet light detection in Caenorhabditis elegans.
C. elegans phototransduction requires a G protein-dependent cGMP pathway and a taste receptor homolog.
The C. elegans taste receptor homolog LITE-1 is a photoreceptor.
KCNQ-like potassium channels in Caenorhabditis elegans. Conserved properties and modulation.
Misexpression of acetylcholinesterases in the C. elegans pha-2 mutant accompanies ultrastructural defects in pharyngeal muscle cells.
pha-2 encodes the C. elegans ortholog of the homeodomain protein HEX and is required for the formation of the pharyngeal isthmus.
The invertebrate lysozyme effector ILYS-3 is systemically activated in response to danger signals and confers antimicrobial protection in C. elegans.
PRDE-1 is a nuclear factor essential for the biogenesis of Ruby motif-dependent piRNAs in C. elegans.
C. elegans ADAMTS ADT-2 regulates body size by modulating TGFbeta signaling and cuticle collagen organization.
aex-3 encodes a novel regulator of presynaptic activity in C. elegans.
Solution structure of the THAP domain from Caenorhabditis elegans C-terminal binding protein (CtBP).
The Caenorhabditis elegans protein CTBP-1 defines a new group of THAP domain-containing CtBP corepressors.
The conserved NAD(H)-dependent corepressor CTBP-1 regulates Caenorhabditis elegans life span.
Meiotic recombination in C. elegans initiates by a conserved mechanism and is dispensable for homologous chromosome synapsis.
Genetic analysis of a major segment [LGV(left)] of the genome of Caenorhabditis elegans.
Genetic and phenotypic characterization of roller mutants of Caenorhabditis elegans.
The generation and genetic analysis of suppressors of lethal mutations in the Caenorhabditis elegans rol-3(V) gene.
Presenilin is required for proper morphology and function of neurons in C. elegans.
The Caenorhabditis elegans presenilin sel-12 is required for mesodermal patterning and muscle function.
Crosstalk between a nuclear receptor and beta-catenin signaling decides cell fates in the C. elegans somatic gonad.
Cyclin E and CDK2 repress the terminal differentiation of quiescent cells after asymmetric division in C. elegans.
Multiple Wnt signaling pathways converge to orient the mitotic spindle in early C. elegans embryos.
POP-1 controls axis formation during early gonadogenesis in C. elegans.
BRCA1/BARD1 orthologs required for DNA repair in Caenorhabditis elegans.
A divergent multi-domain cyclophilin is highly conserved between parasitic and free-living nematode species and is important in larval muscle development.
APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability.
APL-1, the Alzheimer's Amyloid precursor protein in Caenorhabditis elegans, modulates multiple metabolic pathways throughout development.
Intracellular trafficking and synaptic function of APL-1 in Caenorhabditis elegans.
Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological function.
Structural characterization of the E2 domain of APL-1, a Caenorhabditis elegans homolog of human amyloid precursor protein, and its heparin binding site.
The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans.
apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor.
feh-1 and apl-1, the Caenorhabditis elegans orthologues of mammalian Fe65 and beta-amyloid precursor protein genes, are involved in the same pathway that controls nematode pharyngeal pumping.
A role for Caenorhabditis elegans importin IMA-2 in germ line and embryonic mitosis.
Germline and developmental roles of the nuclear transport factor importin alpha3 in C. elegans.
A continuum of mRNP complexes in embryonic microRNA-mediated silencing.
LET-711, the Caenorhabditis elegans NOT1 ortholog, is required for spindle positioning and regulation of microtubule length in embryos.
Processing bodies and germ granules are distinct RNA granules that interact in C. elegans embryos.
C. elegans Brat homologs regulate PAR protein-dependent polarity and asymmetric cell division.
Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins.
A conserved checkpoint pathway mediates DNA damage-induced apoptosis and cell cycle arrest in C. elegans.
Caenorhabditis elegans POT-2 telomere protein represses a mode of alternative lengthening of telomeres with normal telomere lengths.
MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans.
Mutator phenotype of Caenorhabditis elegans DNA damage checkpoint mutants.
RTEL-1 enforces meiotic crossover interference and homeostasis.
RTEL1 maintains genomic stability by suppressing homologous recombination.
Caenorhabditis elegans lin-25: a study of its role in multiple cell fate specification events involving ras and the identification and characterization of evolutionarily conserved domains.
Caenorhabditis elegans lin-25: cellular focus, protein expression and requirement for sur-2 during induction of vulval fates.
Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans.
lin-25, a gene required for vulval induction in Caenorhabditis elegans.
Ce-wts-1 plays important roles in Caenorhabditis elegans development.
Lats kinase is involved in the intestinal apical membrane integrity in the nematode Caenorhabditis elegans.
Embryonic lethality caused by mutations in basement membrane collagen of C. elegans.
Perlecan antagonizes collagen IV and ADAMTS9/GON-1 in restricting the growth of presynaptic boutons.
The two Caenorhabditis elegans basement membrane (type IV) collagen genes are located on separate chromosomes.
A transmembrane protein required for acetylcholine receptor clustering in Caenorhabditis elegans.
Secretion of a novel class of iFABPs in nematodes: coordinate use of the Ascaris/Caenorhabditis model systems.
Localization of a guanylyl cyclase to chemosensory cilia requires the novel ciliary MYND domain protein DAF-25.
C. elegans serine-threonine kinase KIN-29 modulates TGFbeta signaling and regulates body size formation.
Regulation of chemosensory receptor expression and sensory signaling by the KIN-29 Ser/Thr kinase.
EAT-20, a novel transmembrane protein with EGF motifs, is required for efficient feeding in Caenorhabditis elegans.
Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans.
Identification and characterization of a dimerization domain in CED-6, an adapter protein involved in engulfment of apoptotic cells.
Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP).
C. elegans avoids toxin-producing Streptomyces using a seven transmembrane domain chemosensory receptor.
Divergent seven transmembrane receptors are candidate chemosensory receptors in C. elegans.
The permanently chaperone-active small heat shock protein Hsp17 from Caenorhabditis elegans exhibits topological separation of its N-terminal regions.
An acid phosphatase as a biochemical marker for intestinal development in the nematode Caenorhabditis elegans.
A highly conserved centrosomal kinase, AIR-1, is required for accurate cell cycle progression and segregation of developmental factors in Caenorhabditis elegans embryos.
The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response.
The glutathione reductase GSR-1 determines stress tolerance and longevity in Caenorhabditis elegans.
CEH-60/PBX regulates vitellogenesis and cuticle permeability through intestinal interaction with UNC-62/MEIS in Caenorhabditis elegans.
A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation.
Propionyl-CoA and adenosylcobalamin metabolism in Caenorhabditis elegans: evidence for a role of methylmalonyl-CoA epimerase in intermediary metabolism.
C. elegans SIN-3 and its associated HDAC corepressor complex act as mediators of male sensory ray development.
Lysosomal Signaling Promotes Longevity by Adjusting Mitochondrial Activity.
Structural characterization of life-extending Caenorhabditis elegans Lipid Binding Protein 8.
Casein kinase II from Caenorhabditis elegans. Properties and developmental regulation of the enzyme; cloning and sequence analyses of cDNA and the gene for the catalytic subunit.
Engineering a conserved RNA regulatory protein repurposes its biological function in vivo.
Structural recognition of the mRNA 3' UTR by PUF-8 restricts the lifespan of C. elegans.
C. elegans BED domain transcription factor BED-3 controls lineage-specific cell proliferation during organogenesis.
Caenorhabditis elegans msh-5 is required for both normal and radiation-induced meiotic crossing over but not for completion of meiosis.
Cloning and characterization of the human and Caenorhabditis elegans homologs of the Saccharomyces cerevisiae MSH5 gene.
Biochemical and structural characterization of a divergent loop cyclophilin from Caenorhabditis elegans.
First crystal structure of a medicinally relevant gold protein complex: unexpected binding of [Au(PEt3)]+ to histidine.
Immunological detection of alkaline-diaminobenzidine-negative peroxisomes of the nematode Caenorhabditis elegans. Purification and unique pH optima of peroxisomal catalase.
Oxidative stress enzymes are required for DAF-16-mediated immunity due to generation of reactive oxygen species by Caenorhabditis elegans.
EGF signalling activates the ubiquitin proteasome system to modulate C. elegans lifespan.
Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system.
hecd-1 modulates notch activity in Caenorhabditis elegans.
The G protein beta subunit gpb-2 in Caenorhabditis elegans regulates the G(o)alpha-G(q)alpha signaling network through interactions with the regulator of G protein signaling proteins egl-10 and eat-16.
Laminin alpha subunits and their role in C. elegans development.
Mutations in the cell-binding motif of lam-3/laminin alpha reveal hypercontraction behavior and defective sensitivity to levamisole in Caenorhabditis elegans.
MicroRNA silencing through RISC recruitment of eIF6.
The Caenorhabditis elegans gene mfap-1 encodes a nuclear protein that affects alternative splicing.
A multi-protein receptor-ligand complex underlies combinatorial dendrite guidance choices in C. elegans.
Muscle- and Skin-Derived Cues Jointly Orchestrate Patterning of Somatosensory Dendrites.
A robust network of double-strand break repair pathways governs genome integrity during C. elegans development.
BRC-1 acts in the inter-sister pathway of meiotic double-strand break repair.
DNA strand breaks in mitotic germ cells of Caenorhabditis elegans evaluated by comet assay.
Abl kinase inhibits the engulfment of apopotic cells in Caenorhabditis elegans.
Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans.
Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans.
Phagocytosis promotes programmed cell death in C. elegans.
Tandemly duplicated Caenorhabditis elegans collagen genes differ in their modes of splicing.
A branched-chain fatty acid is involved in post-embryonic growth control in parallel to the insulin receptor pathway and its biosynthesis is feedback-regulated in C. elegans.
A glutathione peroxidase, intracellular peptidases and the TOR complexes regulate peptide transporter PEPT-1 in C. elegans.
Altered signalling from germline to intestine pushes daf-2;pept-1 Caenorhabditis elegans into extreme longevity.
Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans.
Metabotyping of Caenorhabditis elegans and their culture media revealed unique metabolic phenotypes associated to amino acid deficiency and insulin-like signaling.
The influence of bacterial diet on fat storage in C. elegans.
Two oligopeptide transporters from Caenorhabditis elegans: molecular cloning and functional expression.
Chondroitin 4-O-sulfotransferase ss indispensable for sulfation of chondroitin and plays an important role in maintaining normal life span and oxidative stress responses in nematodes.
Nematodes join the family of chondroitin sulfate-synthesizing organisms: Identification of an active chondroitin sulfotransferase in Caenorhabditis elegans.
A central role of the BK potassium channel in behavioral responses to ethanol in C. elegans.
Cell Excitability Necessary for Male Mating Behavior in Caenorhabditis elegans is Coordinated by Interactions Between BK and EAG Family K+ Channels.
Cell excitability necessary for male mating behavior in Caenorhabditis elegans is coordinated by interactions between big current and ether-a-go-go family K(+) channels.
SLO-1 potassium channels control quantal content of neurotransmitter release at the C. elegans neuromuscular junction.
A C. elegans E/Daughterless bHLH protein marks neuronal but not striated muscle development.
HLH-3 is a C. elegans Achaete/Scute protein required for differentiation of the hermaphrodite-specific motor neurons.
Extracellular proteins needed for C. elegans mechanosensation.
Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer's disease.
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins.
unc-53 controls longitudinal migration in C. elegans.
Conservation of the centromere/kinetochore protein ZW10.
The C. elegans gene lin-9, which acts in an Rb-related pathway, is required for gonadal sheath cell development and encodes a novel protein.
Balancing selection shapes density-dependent foraging behaviour.
Regulatory changes in two chemoreceptor genes contribute to a Caenorhabditis elegans QTL for foraging behavior.
Transcription reactivation steps stimulated by oocyte maturation in C. elegans.
An RNAi-based dimorphic genetic screen identified the double bromodomain protein BET-1 as a sumo-dependent attenuator of RAS-mediated signalling.
Identification and characterization of the SMT3 cDNA and gene from nematode Caenorhabditis elegans.
Maintenance of muscle myosin levels in adult C. elegans requires both the double bromodomain protein BET-1 and sumoylation.
SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family.
Sumoylation of LIN-1 promotes transcriptional repression and inhibition of vulval cell fates.
An endocytic pathway as a target of tubby for regulation of fat storage.
C. elegans tubby regulates life span and fat storage by two independent mechanisms.
Genetic and molecular analysis of a Caenorhabditis elegans beta-tubulin that conveys benzimidazole sensitivity.
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes.
Polygenic control of Caenorhabditis elegans fat storage.
Control of cell fates in the central body region of C. elegans by the homeobox gene lin-39.
Mutations in synaptojanin disrupt synaptic vesicle recycling.
Synaptojanin cooperates in vivo with endophilin through an unexpected mechanism.
The C. elegans cell death specification gene ces-1 encodes a snail family zinc finger protein.
Functional characterization of Caenorhabditis elegans cbs-2 gene during meiosis.
Eukaryotic translation initiation factor 5B activity regulates larval growth rate and germline development in Caenorhabditis elegans.
The transcription factor HLH-26 controls probiotic-mediated protection against intestinal infection through up-regulation of the Wnt/BAR-1 pathway.
A putative cation channel, NCA-1, and a novel protein, UNC-80, transmit neuronal activity in C. elegans.
Genetic analysis of crawling and swimming locomotory patterns in C. elegans.
Genetic analysis of halothane sensitivity in Caenorhabditis elegans.
Multiple sites of action of volatile anesthetics in Caenorhabditis elegans.
The effect of two genes on anesthetic response in the nematode Caenorhabditis elegans.
UNC-80 and the NCA ion channels contribute to endocytosis defects in synaptojanin mutants.
Qri7/OSGEPL, the mitochondrial version of the universal Kae1/YgjD protein, is essential for mitochondrial genome maintenance.
Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders.
Regulation of chemosensory and GABAergic motor neuron development by the C. elegans Aristaless/Arx homolog alr-1.
The Caenorhabditis elegans aristaless orthologue, alr-1, is required for maintaining the functional and structural integrity of the amphid sensory organs.
NPP-16/Nup50 function and CDK-1 inactivation are associated with anoxia-induced prophase arrest in Caenorhabditis elegans.
The conserved kinases CDK-1, GSK-3, KIN-19, and MBK-2 promote OMA-1 destruction to regulate the oocyte-to-embryo transition in C. elegans.
The identification of a Caenorhabditis elegans homolog of p34cdc2 kinase.
A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development in C. elegans.
Genes regulating touch cell development in Caenorhabditis elegans.
Translational control of maternal glp-1 mRNA by POS-1 and its interacting protein SPN-4 in Caenorhabditis elegans.
Notch signaling is antagonized by SAO-1, a novel GYF-domain protein that interacts with the E3 ubiquitin ligase SEL-10 in Caenorhabditis elegans.
Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling.
A RHO GTPase-mediated pathway is required during P cell migration in Caenorhabditis elegans.
Sequential functioning of the ECT-2 RhoGEF, RHO-1 and CDC-42 establishes cell polarity in Caenorhabditis elegans embryos.
The Caenorhabditis elegans small GTP-binding protein RhoA is enriched in the nerve ring and sensory neurons during larval development.
The DH-PH region of the giant protein UNC-89 activates RHO-1 GTPase in Caenorhabditis elegans body wall muscle.
The RHO-1 RhoGTPase modulates fertility and multiple behaviors in adult C. elegans.
The TAO kinase KIN-18 regulates contractility and establishment of polarity in the C. elegans embryo.
Identification of Caenorhabditis elegans K02H8.1 (CeMBL), a functional ortholog of mammalian MBNL proteins.
Muscleblind, a gene required for photoreceptor differentiation in Drosophila, encodes novel nuclear Cys3His-type zinc-finger-containing proteins.
The ephrin VAB-2/EFN-1 functions in neuronal signaling to regulate epidermal morphogenesis in C. elegans.
Molecular analysis of two genes between let-653 and let-56 in the unc-22(IV) region of Caenorhabditis elegans.
Genetic and molecular analysis of spe-27, a gene required for spermiogenesis in Caenorhabditis elegans hermaphrodites.
Am. J. Med. Genet. B Neuropsychiatr. Genet.
A C. elegans Thermosensory Circuit Regulates Longevity through crh-1/CREB-Dependent flp-6 Neuropeptide Signaling.
CREB mediates the C. elegans dauer polyphenism through direct and cell-autonomous regulation of TGF-beta expression.
Differential Regulation of Innate and Learned Behavior by Creb1/Crh-1 in Caenorhabditis elegans.
Genetic dissection of memory for associative and non-associative learning in Caenorhabditis elegans.
Identification of a CREB-dependent serotonergic pathway and neuronal circuit regulating foraging behavior in Caenorhabditis elegans: a useful model for mental disorders and their treatments?
Characterisation of set-1, a conserved PR/SET domain gene in Caenorhabditis elegans.
Caenorhabditis elegans cyclin A- and B-type genes: a cyclin A multigene family, an ancestral cyclin B3 and differential germline expression.
Coordination of cell proliferation and cell fate determination by CES-1 snail.
A behavioral switch: cGMP and PKC signaling in olfactory neurons reverses odor preference in C. elegans.
The cloning of a Caenorhabditis elegans guanylyl cyclase and the construction of a ligand-sensitive mammalian/nematode chimeric receptor.
Cloning and characterization of cDNAs encoding putative glutamate transporters from Caenorhabditis elegans and Onchocerca volvulus.
Molecular cloning of a cDNA for the glutamate transporter of the nematode Caenorhabditis elegans.
Structure and activity of a new form of the glutamate transporter of the nematode Caenorhabditis elegans.
Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1.
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans.
Sperm development and motility are regulated by PP1 phosphatases in Caenorhabditis elegans.
Cloning and characterization of the Caenorhabditis elegans CeCRMP/DHP-1 and -2; common ancestors of CRMP and dihydropyrimidinase?
The Ulip family phosphoproteins -- common and specific properties.
Disease-related myotubularins function in endocytic traffic in Caenorhabditis elegans.
MTM-6, a phosphoinositide phosphatase, is required to promote synapse formation in Caenorhabditis elegans.
CDC-42 controls early cell polarity and spindle orientation in C. elegans.
Caenorhabditis elegans screen reveals role of PAR-5 in RAB-11-recycling endosome positioning and apicobasal cell polarity.
Cyclin E-Cdk2 temporally regulates centrosome assembly and establishment of polarity in Caenorhabditis elegans embryos.
Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosin.
The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans.
A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity.
Mitochondrial ubiquinone-mediated longevity is marked by reduced cytoplasmic mRNA translation.
Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1.
The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner.
Proteolysis in Caenorhabditis elegans sex determination: cleavage of TRA-2A by TRA-3.
The tra-3 sex determination gene of Caenorhabditis elegans encodes a member of the calpain regulatory protease family.
Identification of two epoxide hydrolases in Caenorhabditis elegans that metabolize mammalian lipid signaling molecules.
Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation.
Decoding of polymodal sensory stimuli by postsynaptic glutamate receptors in C. elegans.
Repression of a potassium channel by nuclear hormone receptor and TGF-beta signaling modulates insulin signaling in Caenorhabditis elegans.
The response to high CO2 levels requires the neuropeptide secretion component HID-1 to promote pumping inhibition.
CUP-1 is a novel protein involved in dietary cholesterol uptake in Caenorhabditis elegans.
Exploring systemic RNA interference in insects: a genome-wide survey for RNAi genes in Tribolium.
SID-1 Domains Important for dsRNA Import in Caenorhabditis elegans.
A metalloprotease disintegrin that controls cell migration in Caenorhabditis elegans.
An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans.
Organ length control by an ADAMTS extracellular protease in Caenorhabditis elegans.
Prodomain-dependent tissue targeting of an ADAMTS protease controls cell migration in Caenorhabditis elegans.
Stage-specific activation of MIG-17/ADAMTS controls cell migration in Caenorhabditis elegans.
The conserved oligomeric Golgi complex acts in organ morphogenesis via glycosylation of an ADAM protease in C. elegans.
Two conserved regulatory cytoplasmic poly(A) polymerases, GLD-4 and GLD-2, regulate meiotic progression in C. elegans.
Chitinases are a multi-gene family in Aedes, Anopheles and Drosophila.
Splicing factor SF1 from Drosophila and Caenorhabditis: presence of an N-terminal RS domain and requirement for viability.
A novel sulfotransferase abundantly expressed in the dauer larvae of Caenorhabditis elegans.
Neurohormonal signaling via a sulfotransferase antagonizes insulin-like signaling to regulate a Caenorhabditis elegans stress response.
Sulfated signal from ASJ sensory neurons modulates stomatin-dependent coordination in Caenorhabditis elegans.
A novel superoxide dismutase gene encoding membrane-bound and extracellular isoforms by alternative splicing in Caenorhabditis elegans.
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span.
MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation.
A molecular evolutionary framework for eukaryotic model organisms.
Nucleolar GTPase NOG-1 regulates development, fat storage, and longevity through insulin/IGF signaling in C. elegans.
The diabetes autoantigen ICA69 and its Caenorhabditis elegans homologue, ric-19, are conserved regulators of neuroendocrine secretion.
Aurora A kinase regulates proper spindle positioning in C. elegans and in human cells.
Mechanism of transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors.
Regulation of a heterodimeric kinesin-2 through an unprocessive motor domain that is turned processive by its partner.
Torque generation by one of the motor subunits of heterotrimeric kinesin-2.
Caenorhabditis elegans has scores of hedgehog-related genes: sequence and expression analysis.
ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells.
EGL-10 regulates G protein signaling in the C. elegans nervous system and shares a conserved domain with many mammalian proteins.
Diverse regulation of sensory signaling by C. elegans nPKC-epsilon/eta TTX-4.
Mitochondrial dysfunction confers resistance to multiple drugs in Caenorhabditis elegans.
PKC-1 acts with the ERK MAPK signaling pathway to regulate Caenorhabditis elegans mechanosensory response.
Reversal of salt preference is directed by the insulin/PI3K and Gq/PKC signaling in Caenorhabditis elegans.
Structure and expression of a novel, neuronal protein kinase C (PKC1B) from Caenorhabditis elegans. PKC1B is expressed selectively in neurons that receive, transmit, and process environmental signals.
pkc-1 regulates daf-2 insulin/IGF signalling-dependent control of dauer formation in Caenorhabditis elegans.
Muscle-Specific Histone H3K36 Dimethyltransferase SET-18 Shortens Lifespan of Caenorhabditis elegans by Repressing daf-16a Expression.
The T-box transcription factors TBX-37 and TBX-38 link GLP-1/Notch signaling to mesoderm induction in C. elegans embryos.
The endocytic pathway mediates cell entry of dsRNA to induce RNAi silencing.
CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin.
Atypical Transcriptional Activation by TCF via a Zic Transcription Factor in C. elegans Neuronal Precursors.
Binary cell fate specification during C. elegans embryogenesis driven by reiterated reciprocal asymmetry of TCF POP-1 and its coactivator beta-catenin SYS-1.
C. elegans Runx/CBFbeta suppresses POP-1 TCF to convert asymmetric to proliferative division of stem cell-like seam cells.
Distinct beta-catenins mediate adhesion and signalling functions in C. elegans.
Reciprocal asymmetry of SYS-1/beta-catenin and POP-1/TCF controls asymmetric divisions in Caenorhabditis elegans.
pop-1 encodes an HMG box protein required for the specification of a mesoderm precursor in early C. elegans embryos.
pop-1/TCF, ref-2/ZIC and T-box factors regulate the development of anterior cells in the C. elegans embryo.
Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans.
A heterochromatin protein 1 homologue in Caenorhabditis elegans acts in germline and vulval development.
Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolism.
Defining heterochromatin in C. elegans through genome-wide analysis of the heterochromatin protein 1 homolog HPL-2.
HPL-2/HP1 prevents inappropriate vulval induction in Caenorhabditis elegans by acting in both HYP7 and vulval precursor cells.
The Caenorhabditis elegans Ortholog of TDP-43 Regulates the Chromatin Localization of the Heterochromatin Protein 1 Homolog HPL-2.
Cadmium-regulated genes from the nematode Caenorhabditis elegans. Identification and cloning of new cadmium-responsive genes by differential display.
Molecular characterization of a novel, cadmium-inducible gene from the nematode Caenorhabditis elegans. A new gene that contributes to the resistance to cadmium toxicity.
Protection of specific maternal messenger RNAs by the P body protein CGH-1 (Dhh1/RCK) during Caenorhabditis elegans oogenesis.
Bifunctional glyoxylate cycle protein of Caenorhabditis elegans: a developmentally regulated protein of intestine and muscle.
Endoplasmic Reticulum Homeostasis Is Modulated by the Forkhead Transcription Factor FKH-9 During Infection of Caenorhabditis elegans.
Solution structure and dynamics of glia maturation factor from Caenorhabditis elegans.
The Eps15 C. elegans homologue EHS-1 is implicated in synaptic vesicle recycling.
An intestinally secreted host factor promotes microsporidia invasion of C. elegans.
Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases.
Components of the SWI/SNF complex are required for asymmetric cell division in C. elegans.
The SWI/SNF chromatin remodeling complex exerts both negative and positive control over LET-23/EGFR-dependent vulval induction in Caenorhabditis elegans.
CHR3: a Caenorhabditis elegans orphan nuclear hormone receptor required for proper epidermal development and molting.
Feedback between a retinoid-related nuclear receptor and the let-7 microRNAs controls the pace and number of molting cycles in C. elegans.
NHR-23 dependent collagen and hedgehog-related genes required for molting.
Nuclear hormone receptor CHR3 is a critical regulator of all four larval molts of the nematode Caenorhabditis elegans.
The conserved molting/circadian rhythm regulator NHR-23/NR1F1 serves as an essential co-regulator of C. elegans spermatogenesis.
Mutation of the feh-1 gene, the Caenorhabditis elegans orthologue of mammalian Fe65, decreases the expression of two acetylcholinesterase genes.
Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans.
The homeobox protein CEH-23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. elegans.
Transcription factors CEP-1/p53 and CEH-23 collaborate with AAK-2/AMPK to modulate longevity in Caenorhabditis elegans.
Mutation of the MAP kinase DYF-5 affects docking and undocking of kinesin-2 motors and reduces their speed in the cilia of Caenorhabditis elegans.
Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance.
Inactivation of the autophagy gene bec-1 triggers apoptotic cell death in C. elegans.
A C-terminal targeting signal controls differential compartmentalisation of Caenorhabditis elegans host cell factor (HCF) to the nucleus or mitochondria.
Developmental and cell-cycle regulation of Caenorhabditis elegans HCF phosphorylation.
Epigenetic regulation of histone H3 serine 10 phosphorylation status by HCF-1 proteins in C. elegans and mammalian cells.
Host cell factor 1 inhibits SKN-1 to modulate oxidative stress responses in Caenorhabditis elegans.
Selected elements of herpes simplex virus accessory factor HCF are highly conserved in Caenorhabditis elegans.
Functional analysis of leucine aminopeptidase in Caenorhabditis elegans.
Operons in C. elegans: polycistronic mRNA precursors are processed by trans-splicing of SL2 to downstream coding regions.
TYRA-2 (F01E11.5): a Caenorhabditis elegans tyramine receptor expressed in the MC and NSM pharyngeal neurons.
Two neuronal, nuclear-localized RNA binding proteins involved in synaptic transmission.
Developmental genetics of chromosome I spermatogenesis-defective mutants in the nematode Caenorhabditis elegans.
SPE-8, a protein-tyrosine kinase, localizes to the spermatid cell membrane through interaction with other members of the SPE-8 group spermatid activation signaling pathway in C. elegans.
Lumen morphogenesis in C. elegans requires the membrane-cytoskeleton linker erm-1.
Most genes encoding cytoplasmic intermediate filament (IF) proteins of the nematode Caenorhabditis elegans are required in late embryogenesis.
spr-2, a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis elegans, is a member of the SET protein subfamily.
Nucleotide sequence of a cDNA clone encoding a Caenorhabditis elegans homolog of mammalian alkyl-dihydroxyacetonephosphate synthase: evolutionary switching of peroxisomal targeting signals.
Multiple ribonuclease H-encoding genes in the Caenorhabditis elegans genome contrasts with the two typical ribonuclease H-encoding genes in the human genome.
A transcription factor controlling development of peripheral sense organs in C. elegans.
The basic helix-loop-helix transcription factors LIN-32 and HLH-2 function together in multiple steps of a C. elegans neuronal sublineage.
The NC1/endostatin domain of Caenorhabditis elegans type XVIII collagen affects cell migration and axon guidance.
7-Methylguanosine diphosphate (m(7)GDP) is not hydrolyzed but strongly bound by decapping scavenger (dcpS) enzymes and potently inhibits their activity.
Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1.
Nematode m7GpppG and m3(2,2,7)GpppG decapping: activities in Ascaris embryos and characterization of C. elegans scavenger DcpS.
The RNA polymerase II subunit RPB-9 recruits the integrator complex to terminate Caenorhabditis elegans piRNA transcription.
Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells.
A Caenorhabditis elegans prospero homologue defines a novel domain.
A pathway for unicellular tube extension depending on the lymphatic vessel determinant Prox1 and on osmoregulation.
Complexity of developmental control: analysis of embryonic cell lineage specification in Caenorhabditis elegans using pes-1 as an early marker.
PES-1 is expressed during early embryogenesis in Caenorhabditis elegans and has homology to the fork head family of transcription factors.
The small GTPase RAB-11 directs polarized exocytosis of the intracellular pathogen N. parisii for fecal-oral transmission from C. elegans.
Sequence comparison of the Caenorhabditis elegans dpy-13 and col-34 genes, and their deduced collagen products.
dpy-13: a nematode collagen gene that affects body shape.
Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling.
Integration of semaphorin-2A/MAB-20, ephrin-4, and UNC-129 TGF-beta signaling pathways regulates sorting of distinct sensory rays in C. elegans.
The divergent C. elegans ephrin EFN-4 functions in embryonic morphogenesis in a pathway independent of the VAB-1 Eph receptor.
The roles of an ephrin and a semaphorin in patterning cell-cell contacts in C. elegans sensory organ development.
mab-20 encodes Semaphorin-2a and is required to prevent ectopic cell contacts during epidermal morphogenesis in Caenorhabditis elegans.
Functional overlap between the mec-8 gene and five sym genes in Caenorhabditis elegans.
Evolutionarily conserved regulation of immunity by the splicing factor RNP-6/PUF60.
Caspase-dependent conversion of Dicer ribonuclease into a death-promoting deoxyribonuclease.
Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans.
New role for DCR-1/dicer in Caenorhabditis elegans innate immunity against the highly virulent bacterium Bacillus thuringiensis DB27.
A novel calcineurin-interacting protein, CNP-3, modulates calcineurin deficient phenotypes in Caenorhabditis elegans.
Alternative splicing of N- and C-termini of a C. elegans ClC channel alters gating and sensitivity to external Cl- and H+.
CLC anion channel regulatory phosphorylation and conserved signal transduction domains.
CLC chloride channels in Caenorhabditis elegans.
CLH-3, a ClC-2 anion channel ortholog activated during meiotic maturation in C. elegans oocytes.
Carboxy terminus splice variation alters ClC channel gating and extracellular cysteine reactivity.
Identification of regulatory phosphorylation sites in a cell volume- and Ste20 kinase-dependent ClC anion channel.
Into ion channel and transporter function. Caenorhabditis elegans ClC-type chloride channels: novel variants and functional expression.
The voltage-gated anion channels encoded by clh-3 regulate egg laying in C. elegans by modulating motor neuron excitability.
Unique gating properties of C. elegans ClC anion channel splice variants are determined by altered CBS domain conformation and the R-helix linker.
An essential function of the C. elegans ortholog of TPX2 is to localize activated aurora A kinase to mitotic spindles.
Functional genomic analysis of C. elegans chromosome I by systematic RNA interference.
Caenorhabditis elegans P5B-type ATPase CATP-5 operates in polyamine transport and is crucial for norspermidine-mediated suppression of RNA interference.
The ornithine decarboxylase gene of Caenorhabditis elegans: cloning, mapping and mutagenesis.
Neurobeachin: a protein kinase A-anchoring, beige/Chediak-Higashi protein homolog implicated in neuronal membrane traffic.
SEL-2, the C. elegans neurobeachin/LRBA homolog, is a negative regulator of lin-12/Notch activity and affects endosomal traffic in polarized epithelial cells.
The Caenorhabditis elegans T-box factor MLS-1 requires Groucho co-repressor interaction for uterine muscle specification.
The T-box factor MLS-1 acts as a molecular switch during specification of nonstriated muscle in C. elegans.
Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis.
Chondroitin acts in the guidance of gonadal distal tip cells in C. elegans.
Chondroitin proteoglycans are involved in cell division of Caenorhabditis elegans.
Nematode chondroitin polymerizing factor showing cell-/organ-specific expression is indispensable for chondroitin synthesis and embryonic cell division.
Activated EGL-15 FGF receptor promotes protein degradation in muscles of Caenorhabditis elegans.
Receptor tyrosine phosphatase CLR-1 acts in skin cells to promote sensory dendrite outgrowth.
clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans.
Molecular cloning and functional characterization of a polyspecific organic anion transporter from Caenorhabditis elegans.
Crystal structure of the C-terminal domain of splicing factor Prp8 carrying retinitis pigmentosa mutants.
The Caenorhabditis elegans spe-26 gene is necessary to form spermatids and encodes a protein similar to the actin-associated proteins kelch and scruin.
3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1.
Genetic regulation of Caenorhabditis elegans lysosome related organelle function.
Caenorhabditis elegans chromosome arms are anchored to the nuclear membrane via discontinuous association with LEM-2.
Regulated lipid synthesis and LEM2/CHMP7 jointly control nuclear envelope closure.
Caenorhabditis elegans EVL-14/PDS-5 and SCC-3 are essential for sister chromatid cohesion in meiosis and mitosis.
N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans.
RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.
Two SET domain containing genes link epigenetic changes and aging in Caenorhabditis elegans.
Proteomic analysis of protein expression profiles during Caenorhabditis elegans development using two-dimensional difference gel electrophoresis.
IFTA-2 is a conserved cilia protein involved in pathways regulating longevity and dauer formation in Caenorhabditis elegans.
Shared receptors in axon guidance: SAX-3/Robo signals via UNC-34/Enabled and a Netrin-independent UNC-40/DCC function.
Identification and functional analysis of mitochondrial complex I assembly factor homologues in C. elegans.
Genetic and molecular characterization of the Caenorhabditis elegans spermatogenesis-defective gene spe-17.
The Caenorhabditis elegans unc-78 gene encodes a homologue of actin-interacting protein 1 required for organized assembly of muscle actin filaments.
Caenorhabditis elegans RNA-processing protein TDP-1 regulates protein homeostasis and life span.
TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA.
TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans.
Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase.
Additional genes which result in an elevation of acetylcholine levels by mutations in Caenorhabditis elegans.
The Caenorhabditis elegans unc-64 locus encodes a syntaxin that interacts genetically with synaptobrevin.
Nuclear export of ubiquitinated proteins via the UBIN-POST system.
daf-31 encodes the catalytic subunit of N alpha-acetyltransferase that regulates Caenorhabditis elegans development, metabolism and adult lifespan.
A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2.
The Caenorhabditis elegans ortholog of C21orf80, a potential new protein O-fucosyltransferase, is required for normal development.
Caenorhabditis elegans par2.1/mtssb-1 is essential for mitochondrial DNA replication and its defect causes comprehensive transcriptional alterations including a hypoxia response.
Caenorhabditis elegans, a pluricellular model organism to screen new genes involved in mitochondrial genome maintenance.
RTCB-1 mediates neuroprotection via XBP-1 mRNA splicing in the unfolded protein response pathway.
The RtcB RNA ligase is an essential component of the metazoan unfolded protein response.
Investigating the role of RIO protein kinases in Caenorhabditis elegans.
Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress.
Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown.
A feedback loop governs the relationship between lipid metabolism and longevity.
Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response.
The mitochondrial unfolded protein response protects against anoxia in Caenorhabditis elegans.
Caenorhabditis elegans TAC-1 and ZYG-9 form a complex that is essential for long astral and spindle microtubules.
Identification and characterization of factors required for microtubule growth and nucleation in the early C. elegans embryo.
Mos1-mediated transgenesis to probe consequences of single gene mutations in variation-rich isolates of Caenorhabditis elegans.
TAC-1 and ZYG-9 form a complex that promotes microtubule assembly in C. elegans embryos.
TAC-1, a regulator of microtubule length in the C. elegans embryo.
ZYG-9, TAC-1 and ZYG-8 together ensure correct microtubule function throughout the cell cycle of C. elegans embryos.
Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export.
A non-cell-autonomous role for Ras signaling in C. elegans neuroblast delamination.
An activating mutation in sos-1 identifies its Dbl domain as a critical inhibitor of the epidermal growth factor receptor pathway during Caenorhabditis elegans vulval development.
Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals.
Homeodomain interacting protein kinase (HPK-1) is required in the soma for robust germline proliferation in C. elegans.
Homeodomain-Interacting Protein Kinase (HPK-1) regulates stress responses and ageing in C. elegans.
The C. elegans TPR containing protein, TRD-1, regulates cell fate choice in the developing germ line and epidermis.
An integrated serotonin and octopamine neuronal circuit directs the release of an endocrine signal to control C. elegans body fat.
Chimeric mutations in the M2 segment of the 5-hydroxytryptamine-gated chloride channel MOD-1 define a minimal determinant of anion/cation permeability.
Different binding orientations for the same agonist at homologous receptors: a lock and key or a simple wedge?
MOD-1 is a serotonin-gated chloride channel that modulates locomotory behaviour in C. elegans.
Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans.
Receptors and other signaling proteins required for serotonin control of locomotion in Caenorhabditis elegans.
The G-protein-coupled serotonin receptor SER-1 regulates egg laying and male mating behaviors in Caenorhabditis elegans.
Three distinct amine receptors operating at different levels within the locomotory circuit are each essential for the serotonergic modulation of chemosensation in Caenorhabditis elegans.
An AP2 transcription factor is required for a sleep-active neuron to induce sleep-like quiescence in C. elegans.
Caenorhabditis elegans T-box genes tbx-9 and tbx-8 are required for formation of hypodermis and body-wall muscle in embryogenesis.
EGF signal propagation during C. elegans vulval development mediated by ROM-1 rhomboid.
The gene lin-3 encodes an inductive signal for vulval development in C. elegans.
A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging.
Control of body size by SMA-5, a homolog of MAP kinase BMK1/ERK5, in C. elegans.
Mutants carrying two sma mutations are super small in the nematode C. elegans.
The UNC-14 protein required for axonal elongation and guidance in Caenorhabditis elegans interacts with the serine/threonine kinase UNC-51.
abf-1 and abf-2, ASABF-type antimicrobial peptide genes in Caenorhabditis elegans.
Caenorhabditis elegans TRPA-1 functions in mechanosensation.
Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human.
Protection of C. elegans from anoxia by HYL-2 ceramide synthase.
A unique serine-specific elongation factor Tu found in nematode mitochondria.
Identification of the residues involved in the unique serine specificity of Caenorhabditis elegans mitochondrial EF-Tu2.
HIM-10 is required for kinetochore structure and function on Caenorhabditis elegans holocentric chromosomes.
The Caenorhabditis elegans kinetochore reorganizes at prometaphase and in response to checkpoint stimuli.
GRAS-1 is a novel regulator of early meiotic chromosome dynamics in C. elegans.
Tetraspanin protein (TSP-15) is required for epidermal integrity in Caenorhabditis elegans.
Analysis of C. elegans NR2E nuclear receptors defines three conserved clades and ligand-independent functions.
The fax-1 nuclear hormone receptor regulates axon pathfinding and neurotransmitter expression.
Identification of genes required for cytoplasmic localization in early C. elegans embryos.
MEX-5 asymmetry in one-cell C. elegans embryos requires PAR-4- and PAR-1-dependent phosphorylation.
PAR-1 is required for morphogenesis of the Caenorhabditis elegans vulva.
par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed.
C. elegans VAB-8 and UNC-73 regulate the SAX-3 receptor to direct cell and growth-cone migrations.
The C. elegans gene vab-8 guides posteriorly directed axon outgrowth and cell migration.
VAB-8, UNC-73 and MIG-2 regulate axon polarity and cell migration functions of UNC-40 in C. elegans.
vab-8 is a key regulator of posteriorly directed migrations in C. elegans and encodes a novel protein with kinesin motor similarity.
A network of stimulatory and inhibitory Galpha-subunits regulates olfaction in Caenorhabditis elegans.
Molecular evolution and quantitative variation for chemosensory behaviour in the nematode genus Caenorhabditis.
The G alpha protein ODR-3 mediates olfactory and nociceptive function and controls cilium morphogenesis in C. elegans olfactory neurons.
Identification and characterization of a putative C. elegans potassium channel gene (Ce-slo-2) distantly related to Ca(2+)-activated K(+) channels.
The mec-7 beta-tubulin gene of Caenorhabditis elegans is expressed primarily in the touch receptor neurons.
mec-15 encodes an F-box protein required for touch receptor neuron mechanosensation, synapse formation and development.
mec-7 is a beta-tubulin gene required for the production of 15-protofilament microtubules in Caenorhabditis elegans.
A novel WD40 protein, CHE-2, acts cell-autonomously in the formation of C. elegans sensory cilia.
A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in Caenorhabditis elegans.
Chemosensory neurons function in parallel to mediate a pheromone response in C. elegans.
DAF-7/TGF-beta expression required for the normal larval development in C. elegans is controlled by a presumed guanylyl cyclase DAF-11.
Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans.
Multiple chemosensory defects in daf-11 and daf-21 mutants of Caenorhabditis elegans.
Postembryonic expression of Caenorhabditis elegans mab-21 and its requirement in sensory ray differentiation.
Stress-induced phenocopy of C. elegans defines functional steps of sensory organ differentiation.
The mab-21 gene of Caenorhabditis elegans encodes a novel protein required for choice of alternate cell fates.
Sequence and transmembrane topology of MEC-4, an ion channel subunit required for mechanotransduction in Caenorhabditis elegans.
The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration.
Loss of MTX2 causes mandibuloacral dysplasia and links mitochondrial dysfunction to altered nuclear morphology.
Homeobox containing genes in the nematode Caenorhabditis elegans.
A Tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans.
C. elegans cell migration gene mig-10 shares similarities with a family of SH2 domain proteins and acts cell nonautonomously in excretory canal development.
Mutations affecting embryonic cell migrations in Caenorhabditis elegans.
The nonmuscle myosin regulatory light chain gene mlc-4 is required for cytokinesis, anterior-posterior polarity, and body morphology during Caenorhabditis elegans embryogenesis.
Autophagy facilitates mitochondrial rebuilding after acute heat stress via a DRP-1-dependent process.
C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane.
The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity.
A TOCA/CDC-42/PAR/WAVE functional module required for retrograde endocytic recycling.
Spatial control of active CDC-42 during collective migration of hypodermal cells in Caenorhabditis elegans.
Structures of the TMC-1 complex illuminate mechanosensory transduction.
A nematode gene required for sperm vesicle fusion.
Regulation of sperm activation by SWM-1 is required for reproductive success of C. elegans males.
Soma-germ line interactions and a role for muscle in the regulation of C. elegans sperm motility.
TRY-5 Is a Sperm-Activating Protease in Caenorhabditis elegans Seminal Fluid.
A genetic pathway for regulation of tra-2 translation.
Conservation of the C.elegans tra-2 3'UTR translational control.
RNA remodeling activity of DEAD box proteins tuned by protein concentration, RNA length, and ATP.
The C. elegans sex determination gene laf-1 encodes a putative DEAD-box RNA helicase.
The DEAD Box RNA helicase VBH-1 is a new player in the stress response in C. elegans.
The disordered P granule protein LAF-1 drives phase separation into droplets with tunable viscosity and dynamics.
A broad but restricted requirement for TAF-5 (human TAFII100) for embryonic transcription in Caenorhabditis elegans.
Structural model of microtubule dynamics inhibition by kinesin-4 from the crystal structure of KLP-12 -tubulin complex.
Molecular biological studies of the cardiac sodium-calcium exchanger.
The organization of the human gene NCX1 encoding the sodium-calcium exchanger.
A cuticle collagen encoded by the lon-3 gene may be a target of TGF-beta signaling in determining Caenorhabditis elegans body shape.
Increased or decreased levels of Caenorhabditis elegans lon-3, a gene encoding a collagen, cause reciprocal changes in body length.
SESN-1 is a positive regulator of lifespan in Caenorhabditis elegans.
Function of a STIM1 homologue in C. elegans: evidence that store-operated Ca2+ entry is not essential for oscillatory Ca2+ signaling and ER Ca2+ homeostasis.
Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1).
A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.
A two-gene balance regulates Salmonella typhimurium tolerance in the nematode Caenorhabditis elegans.
Genomic clusters, putative pathogen recognition molecules, and antimicrobial genes are induced by infection of C. elegans with M. nematophilum.
Orthosiphon stamineus protects Caenorhabditis elegans against Staphylococcus aureus infection through immunomodulation.
Specificity and complexity of the Caenorhabditis elegans innate immune response.
Studies on Shigella boydii infection in Caenorhabditis elegans and bioinformatics analysis of immune regulatory protein interactions.
A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans.
DAF-12 regulates a connected network of genes to ensure robust developmental decisions.
Nuclear hormone receptor regulation of microRNAs controls innate immune responses in C. elegans.
Overlapping but separable determinants of DNA binding and nuclear localization map to the C-terminal end of the Caenorhabditis elegans DAF-12 DNA binding domain.
Sterol-derived hormone(s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16.
Structure and expression of daf-12: a nuclear hormone receptor with three isoforms that are involved in development and aging in Caenorhabditis elegans.
The nuclear hormone receptor DAF-12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long-lived worms.
The nuclear receptor DAF-12 regulates nutrient metabolism and reproductive growth in nematodes.
daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans.
Clarinet (CLA-1), a novel active zone protein required for synaptic vesicle clustering and release.
Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding.
The vitelliform macular dystrophy protein defines a new family of chloride channels.
Human GABARAP can restore autophagosome biogenesis in a C. elegans lgg-1 mutant.
The autophagosomal protein LGG-2 acts synergistically with LGG-1 in dauer formation and longevity in C. elegans.
Cloning and developmental regulation of a novel member of the insulin-like gene family in Caenorhabditis elegans.
Hierarchical assembly of presynaptic components in defined C. elegans synapses.
SYD-1, a presynaptic protein with PDZ, C2 and rhoGAP-like domains, specifies axon identity in C. elegans.
SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS.
Regulation of presynaptic terminal organization by C. elegans RPM-1, a putative guanine nucleotide exchanger with a RING-H2 finger domain.
rpm-1, a conserved neuronal gene that regulates targeting and synaptogenesis in C. elegans.
Regulation of MBK-2/Dyrk kinase by dynamic cortical anchoring during the oocyte-to-zygote transition.
The minibrain kinase homolog, mbk-2, is required for spindle positioning and asymmetric cell division in early C. elegans embryos.
Identification and characterization of an animal delta(12) fatty acid desaturase gene by heterologous expression in Saccharomyces cerevisiae.
Caenorhabditis elegans LET-502 is related to Rho-binding kinases and human myotonic dystrophy kinase and interacts genetically with a homolog of the regulatory subunit of smooth muscle myosin phosphatase to affect cell shape.
Genetic interactions between UNC-17/VAChT and a novel transmembrane protein in Caenorhabditis elegans.
An evolutionarily conserved gene required for proper microtubule architecture in Caenorhabditis elegans.
Identification of nonviable genes affecting touch sensitivity in Caenorhabditis elegans using neuronally enhanced feeding RNA interference.
Structure, expression, and evolution of a heat shock gene locus in Caenorhabditis elegans that is flanked by repetitive elements.
Caenorhabditis elegans genomic response to soil bacteria predicts environment-specific genetic effects on life history traits.
Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling.
Cloning, baculovirus expression, and characterization of the alpha subunit of prolyl 4-hydroxylase from the nematode Caenorhabditis elegans. This alpha subunit forms an active alpha beta dimer with the human protein disulfide isomerase/beta subunit.
KSAYMRFamide (PF3/AF8) is present in the free-living nematode, Caenorhabditis elegans.
Crystal structure of the cytoskeleton-associated protein glycine-rich (CAP-Gly) domain.
Solution structure of a ubiquitin-like domain from tubulin-binding cofactor B.
Caenorhabditis elegans myotubularin MTM-1 negatively regulates the engulfment of apoptotic cells.
Identification of thermosensory and olfactory neuron-specific genes via expression profiling of single neuron types.
The Caenorhabditis elegans ADAMTS family gene adt-1 is necessary for morphogenesis of the male copulatory organs.
toca-1 is in a novel pathway that functions in parallel with a SUN-KASH nuclear envelope bridge to move nuclei in Caenorhabditis elegans.
Characterization of a novel protein kinase D: Caenorhabditis elegans DKF-1 is activated by translocation-phosphorylation and regulates movement and growth in vivo.
Conserved domains subserve novel mechanisms and functions in DKF-1, a Caenorhabditis elegans protein kinase D.
Reduction of Caenorhabditis elegans frataxin increases sensitivity to oxidative stress, reduces lifespan, and causes lethality in a mitochondrial complex II mutant.
SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion.
The P4-ATPase TAT-5 inhibits the budding of extracellular vesicles in C. elegans embryos.
CRELD1 is an evolutionarily-conserved maturational enhancer of ionotropic acetylcholine receptors.
Nucleotide sequence of ribosomal protein L3 cDNA and the exon-intron structure of L3 gene in the nematode, Caenorhabditis elegans.
Extensive and modular intrinsically disordered segments in C. elegans TTN-1 and implications in filament binding, elasticity and oblique striation.
Nuclear titin interacts with A- and B-type lamins in vitro and in vivo.
Single-molecule force spectroscopy reveals a stepwise unfolding of Caenorhabditis elegans giant protein kinase domains.
Titins in C.elegans with unusual features: coiled-coil domains, novel regulation of kinase activity and two new possible elastic regions.
Knock-out of a mitochondrial sirtuin protects neurons from degeneration in Caenorhabditis elegans.
Deubiquitylation machinery is required for embryonic polarity in Caenorhabditis elegans.
The deubiquitinating enzyme USP-46 negatively regulates the degradation of glutamate receptors to control their abundance in the ventral nerve cord of Caenorhabditis elegans.
Microbial Siderophore Enterobactin Promotes Mitochondrial Iron Uptake and Development of the Host via Interaction with ATP Synthase.
Cofactor-independent phosphoglycerate mutase has an essential role in Caenorhabditis elegans and is conserved in parasitic nematodes.
Molecular and biochemical characterization of nematode cofactor independent phosphoglycerate mutases.
ttm-1 encodes CDF transporters that excrete zinc from intestinal cells of C. elegans and act in a parallel negative feedback circuit that promotes homeostasis.
sma-1 encodes a betaH-spectrin homolog required for Caenorhabditis elegans morphogenesis.
Reconstitution of invertebrate glutamate receptor function depends on stargazin-like proteins.
Pioneer axon guidance by UNC-129, a C. elegans TGF-beta.
Regulation of UNC-130/FOXD-mediated mesodermal patterning in C. elegans.
The forkhead transcription factor UNC-130 is required for the graded spatial expression of the UNC-129 TGF-beta guidance factor in C. elegans.
UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways.
The hydrolethalus syndrome protein HYLS-1 links core centriole structure to cilia formation.
A directed RNAi screen based on larval growth arrest reveals new modifiers of C. elegans insulin signaling.
ARI-1, an RBR family ubiquitin-ligase, functions with UBC-18 to regulate pharyngeal development in C. elegans.
Soma-germline asymmetry in the distributions of embryonic RNAs in Caenorhabditis elegans.
Katanin spiral and ring structures shed light on power stroke for microtubule severing.
Localization of the mei-1 gene product of Caenorhaditis elegans, a meiotic-specific spindle component.
Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.
The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase.
mei-1, a gene required for meiotic spindle formation in Caenorhabditis elegans, is a member of a family of ATPases.
Structure of sperm-specific protein SSP-19 from Caenorhabditis elegans.
Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan.
Lysosome biogenesis mediated by vps-18 affects apoptotic cell degradation in Caenorhabditis elegans.
Alternative splicing regulation during C. elegans development: splicing factors as regulated targets.
C. elegans HLH-2/E/Daughterless controls key regulatory cells during gonadogenesis.
HLH-2/E2A Expression Links Stochastic and Deterministic Elements of a Cell Fate Decision during C. elegans Gonadogenesis.
Post-transcriptional regulation of the E/Daughterless ortholog HLH-2, negative feedback, and birth order bias during the AC/VU decision in C. elegans.
The transcription factor HLH-2/E/Daughterless regulates anchor cell invasion across basement membrane in C. elegans.
Protein L-isoaspartyl methyltransferase from the nematode Caenorhabditis elegans: genomic structure and substrate specificity.
Roles of the C. elegans cyclophilin-like protein MOG-6 in MEP-1 binding and germline fates.
Basolateral targeting by leucine-rich repeat domains in epithelial cells.
LET-413 is a basolateral protein required for the assembly of adherens junctions in Caenorhabditis elegans.
The apical disposition of the Caenorhabditis elegans intestinal terminal web is maintained by LET-413.
TMCO1 is an ER Ca(2+) load-activated Ca(2+) channel.
HES-Mediated Repression of Pten in Caenorhabditis elegans.
RME-8, a conserved J-domain protein, is required for endocytosis in Caenorhabditis elegans.
cec-1, a soma-specific chromobox-containing gene in C. elegans.
Function of the Caenorhabditis elegans ABC transporter PGP-2 in the biogenesis of a lysosome-related fat storage organelle.
The evolutionarily conserved gene LNP-1 is required for synaptic vesicle trafficking and synaptic transmission.
Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans.
Evolutionarily conserved nuclear migration genes required for early embryonic development in Caenorhabditis elegans.
lis-1 is required for dynein-dependent cell division processes in C. elegans embryos.
Mechanisms controlling sex myoblast migration in Caenorhabditis elegans hermaphrodites.
The conserved immunoglobulin superfamily member SAX-3/Robo directs multiple aspects of axon guidance in C. elegans.
A mutational analysis of Caenorhabditis elegans in space.
Additional sequence complexity in the muscle gene, unc-22, and its encoded protein, twitchin, of Caenorhabditis elegans.
Identification and intracellular localization of the unc-22 gene product of Caenorhabditis elegans.
Insights into autoregulation from the crystal structure of twitchin kinase.
Mutants with altered muscle structure of Caenorhabditis elegans.
Sequence of an unusually large protein implicated in regulation of myosin activity in C. elegans.
Structure and stability of an immunoglobulin superfamily domain from twitchin, a muscle protein of the nematode Caenorhabditis elegans.
Functional domains of LAG-2, a putative signaling ligand for LIN-12 and GLP-1 receptors in Caenorhabditis elegans.
Sequence of C. elegans lag-2 reveals a cell-signalling domain shared with Delta and Serrate of Drosophila.
Spatial regulation of lag-2 transcription during vulval precursor cell fate patterning in Caenorhabditis elegans.
Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4-hydroxynonenal.
Lifespan extension in hypomorphic daf-2 mutants of Caenorhabditis elegans is partially mediated by glutathione transferase CeGSTP2-2.
Genetic suppressors of Caenorhabditis elegans pha-4/FoxA identify the predicted AAA helicase ruvb-1/RuvB.
LINKIN, a new transmembrane protein necessary for cell adhesion.
The Target of Rapamycin pathway antagonizes pha-4/FoxA to control development and aging.
Sex-specific pruning of neuronal synapses in Caenorhabditis elegans.
UBQLN4 represses homologous recombination and is overexpressed in aggressive tumors.
Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD.
zyg-8, a gene required for spindle positioning in C. elegans, encodes a doublecortin-related kinase that promotes microtubule assembly.
Cathepsin L is essential for embryogenesis and development of Caenorhabditis elegans.
Cathepsin L protease (CPL-1) is essential for yolk processing during embryogenesis in Caenorhabditis elegans.
Genetics of Lipid-Storage Management in Caenorhabditis elegans Embryos.
The lysosomal cathepsin protease CPL-1 plays a leading role in phagosomal degradation of apoptotic cells in Caenorhabditis elegans.
The gut esterase gene (ges-1) from the nematodes Caenorhabditis elegans and Caenorhabditis briggsae.
A stomatin-like protein necessary for mechanosensation in C. elegans.
CAR-1, a protein that localizes with the mRNA decapping component DCAP-1, is required for cytokinesis and ER organization in Caenorhabditis elegans embryos.
Restriction of cellular plasticity of differentiated cells mediated by chromatin modifiers, transcription factors and protein kinases.
The ZFP-1(AF10)/DOT-1 complex opposes H2B ubiquitination to reduce Pol II transcription.
RNF-121 is an endoplasmic reticulum-membrane E3 ubiquitin ligase involved in the regulation of beta-integrin.
Structural basis of preferential binding of fucose-containing saccharide by the Caenorhabditis elegans galectin LEC-6.
Autosomal genes of autosomal/X-linked duplicated gene pairs and germ-line proliferation in Caenorhabditis elegans.
Characterization of seven genes affecting Caenorhabditis elegans hindgut development.
EGL-38 Pax regulates the ovo-related gene lin-48 during Caenorhabditis elegans organ development.
Evolutionary innovation of the excretory system in Caenorhabditis elegans.
Discovery of a cholecystokinin-gastrin-like signaling system in nematodes.
Functional specialization of sensory cilia by an RFX transcription factor isoform.
The RFX-type transcription factor DAF-19 regulates sensory neuron cilium formation in C. elegans.
The zinc finger protein REF-2 functions with the Hox genes to inhibit cell fusion in the ventral epidermis of C. elegans.
Molecular cloning and characterization of dullard: a novel gene required for neural development.
The inducible elongin A elongation activation domain: structure, function and interaction with the elongin BC complex.
Pore architecture of TRIC channels and insights into their gating mechanism.
Characterization of the Caenorhabditis elegans Islet LIM-homeodomain ortholog, lim-7.
Interactions between LHX3- and ISL1-family LIM-homeodomain transcription factors are conserved in Caenorhabditis elegans.
Analysis of the Caenorhabditis elegans axonal guidance and outgrowth gene unc-33.
Local microtubule organization promotes cargo transport in C. elegans dendrites.
Regulatory machinery of UNC-33 Ce-CRMP localization in neurites during neuronal development in Caenorhabditis elegans.
UNC-33 (CRMP) and ankyrin organize microtubules and localize kinesin to polarize axon-dendrite sorting.
The conserved KMN network constitutes the core microtubule-binding site of the kinetochore.
aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.
Regulation of apoptosis by a Caenorhabditis elegans BNIP3 homolog.
Copulation in C. elegans males requires a nuclear hormone receptor.
Genetic transformation of the synaptic pattern of a motoneuron class in Caenorhabditis elegans.
UNC-55, an orphan nuclear hormone receptor, orchestrates synaptic specificity among two classes of motor neurons in Caenorhabditis elegans.
ICln ion channel splice variants in Caenorhabditis elegans: voltage dependence and interaction with an operon partner protein.
Cysteine protease cathepsin B mediates radiation-induced bystander effects.
ELLI-1, a novel germline protein, modulates RNAi activity and P-granule accumulation in Caenorhabditis elegans.
Characterization of the human NIPSNAP1 gene from 22q12: a member of a novel gene family.
Complex patterns of alternative splicing mediate the spatial and temporal distribution of perlecan/UNC-52 in Caenorhabditis elegans.
Products of the unc-52 gene in Caenorhabditis elegans are homologous to the core protein of the mammalian basement membrane heparan sulfate proteoglycan.
Centrosome maturation and mitotic spindle assembly in C. elegans require SPD-5, a protein with multiple coiled-coil domains.
A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling.
The sys-1 and sys-3 genes cooperate with Wnt signaling to establish the proximal-distal axis of the Caenorhabditis elegans gonad.
Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell.
Structure of the trehalose-6-phosphate phosphatase from Brugia malayi reveals key design principles for anthelmintic drugs.
The C. elegans lethal gut-obstructed gob-1 gene is trehalose-6-phosphate phosphatase.
Caenorhabditis elegans MAI-1 protein, which is similar to mitochondrial ATPase inhibitor (IF1), can inhibit yeast F0F1-ATPase but cannot be transported to yeast mitochondria.
A neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C. elegans lifespan.
Reduction of mitoferrin results in abnormal development and extended lifespan in Caenorhabditis elegans.
The activation of protein homeostasis protective mechanisms perhaps is not responsible for lifespan extension caused by deficiencies of mitochondrial proteins in C. elegans.
TRA-1/GLI controls development of somatic gonadal precursors in C. elegans.
The C. elegans Hand gene controls embryogenesis and early gonadogenesis.
A new gene family including DSCR1 (Down syndrome candidate region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2).
The Arf GAP CNT-2 regulates the apoptotic fate in C. elegans asymmetric neuroblast divisions.
Molecular cloning and characterization of the dpy-20 gene of Caenorhabditis elegans.
An intestinal microRNA modulates the homeostatic adaptation to chronic oxidative stress in C. elegans.
A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction.
Protein phosphatase 2A cooperates with the autophagy-related kinase UNC-51 to regulate axon guidance in Caenorhabditis elegans.
Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors.
A fasting-responsive signaling pathway that extends life span in C. elegans.
An age-dependent reversal in the protective capacities of JNK signaling shortens Caenorhabditis elegans lifespan.
Global functional analyses of cellular responses to pore-forming toxins.
CCAAT/enhancer-binding protein CEBP-2 controls fat consumption and fatty acid desaturation in Caenorhabditis elegans.
The C. elegans CCAAT-Enhancer-Binding Protein Gamma Is Required for Surveillance Immunity.
Ceramide glucosyltransferase of the nematode Caenorhabditis elegans is involved in oocyte formation and in early embryonic cell division.
Expression of ceramide glucosyltransferases, which are essential for glycosphingolipid synthesis, is only required in a small subset of C. elegans cells.
Glucosylceramide synthases, a gene family responsible for the biosynthesis of glucosphingolipids in animals, plants, and fungi.
The glycosylceramides of the nematode Caenorhabditis elegans contain an unusual, branched-chain sphingoid base.
Mutations in PURA cause profound neonatal hypotonia, seizures, and encephalopathy in 5q31.3 microdeletion syndrome.
PLP-1 binds nematode double-stranded telomeric DNA.
Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex.
Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms.
The tubulin deglutamylase CCPP-1 regulates the function and stability of sensory cilia in C. elegans.
The hedgehog-related gene wrt-5 is essential for hypodermal development in Caenorhabditis elegans.
Axon regeneration requires a conserved MAP kinase pathway.
C. elegans RPM-1 regulates axon termination and synaptogenesis through the Rab GEF GLO-4 and the Rab GTPase GLO-1.
Cellular and molecular determinants targeting the Caenorhabditis elegans PHR protein RPM-1 to perisynaptic regions.
Context-dependent modulation of Pol II CTD phosphatase SSUP-72 regulates alternative polyadenylation in neuronal development.
DLK-1/p38 MAP Kinase signaling controls cilium length by regulating RAB-5 mediated endocytosis in Caenorhabditis elegans.
Regulation of DLK-1 kinase activity by calcium-mediated dissociation from an inhibitory isoform.
odr-10 encodes a seven transmembrane domain olfactory receptor required for responses to the odorant diacetyl.
Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus.
Cdc37-Hsp90 complexes are responsive to nucleotide-induced conformational changes and binding of further cofactors.
A role for Set1/MLL-related components in epigenetic regulation of the Caenorhabditis elegans germ line.
Methylation and demethylation activities of a C. elegans MLL-like complex attenuate RAS signalling.
RNA recognition by the Caenorhabditis elegans oocyte maturation determinant OMA-1.
The NCLX-type Na(+)/Ca(2+) exchanger NCX-9 is required for patterning of neural circuits in Caenorhabditis elegans.
AMP-activated kinase regulates lipid droplet localization and stability of adipose triglyceride lipase in C. elegans dauer larvae.
Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival.
Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis elegans.
The causative gene in Chanarian Dorfman syndrome regulates lipid droplet homeostasis in C. elegans.
Mitochondrial modulation of phosphine toxicity and resistance in Caenorhabditis elegans.
The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans.
DAPK interacts with Patronin and the microtubule cytoskeleton in epidermal development and wound repair.
Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation.
Negative regulation of Caenorhabditis elegans epidermal damage responses by death-associated protein kinase.
Tissue-specific regulation of alternative polyadenylation represses expression of a neuronal ankyrin isoform in C. elegans epidermal development.
The C. elegans Spalt-like protein SEM-4 functions through the SoxC transcription factor SEM-2 to promote a proliferative blast cell fate in the postembryonic mesoderm.
The Caenorhabditis elegans gene sem-4 controls neuronal and mesodermal cell development and encodes a zinc finger protein.
The SEM-4 Transcription Factor Is Required for Regulation of the Oxidative Stress Response in Caenorhabditis elegans.
sem-4 promotes vulval cell-fate determination in Caenorhabditis elegans through regulation of lin-39 Hox.
Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA.
Cytoplasmic partitioning of P granule components is not required to specify the germline in C. elegans.
DHS-21, a dicarbonyl/L-xylulose reductase (DCXR) ortholog, regulates longevity and reproduction in Caenorhabditis elegans.
Caenorhabditis elegans NONO-1: Insights into DBHS protein structure, architecture, and function.
A Wnt signaling pathway controls hox gene expression and neuroblast migration in C. elegans.
Functional interaction between beta-catenin and FOXO in oxidative stress signaling.
Identification of evolutionarily conserved promoter elements and amino acids required for function of the C. elegans beta-catenin homolog BAR-1.
LIN-23-mediated degradation of beta-catenin regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of C. elegans.
The beta-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development.
Protein phosphatase 4 promotes chromosome pairing and synapsis, and contributes to maintaining crossover competence with increasing age.
Experience-dependent modulation of C. elegans behavior by ambient oxygen.
Transformation of the germ line into muscle in mes-1 mutant embryos of C. elegans.
SID-5 is an endosome-associated protein required for efficient systemic RNAi in C. elegans.
Membrane fluidity is regulated by the C. elegans transmembrane protein FLD-1 and its human homologs TLCD1/2.
The Paired-box protein PAX-3 regulates the choice between lateral and ventral epidermal cell fates in C. elegans.
The frataxin-encoding operon of Caenorhabditis elegans shows complex structure and regulation.
Crystal structure of the worm NitFhit Rosetta stone protein reveals a Nit tetramer binding two Fhit dimers.
Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans.
CUL-2 and ZYG-11 promote meiotic anaphase II and the proper placement of the anterior-posterior axis in C. elegans.
Molecular analysis of zyg-11, a maternal-effect gene required for early embryogenesis of Caenorhabditis elegans.
Zyg-11 and cul-2 regulate progression through meiosis II and polarity establishment in C. elegans.
Hormonal control of C. elegans dauer formation and life span by a Rieske-like oxygenase.
The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity.
The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol-metabolizing enzyme.
Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo.
The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans.
Steroids as central regulators of organismal development and lifespan.
Expression profiling of MAP kinase-mediated meiotic progression in Caenorhabditis elegans.
MEC-12, an alpha-tubulin required for touch sensitivity in C. elegans.
MEC-17 is an alpha-tubulin acetyltransferase.
The slit receptor EVA-1 coactivates a SAX-3/Robo mediated guidance signal in C. elegans.
A yeast two-hybrid screen for SYP-3 interactors identifies SYP-4, a component required for synaptonemal complex assembly and chiasma formation in Caenorhabditis elegans meiosis.
Organization of the synaptonemal complex during meiosis in Caenorhabditis elegans.
Polo-like kinase-dependent phosphorylation of the synaptonemal complex protein SYP-4 regulates double-strand break formation through a negative feedback loop.
Isolation and preliminary biological assessment of AADGAPLIRFamide and SVPGVLRFamide from Caenorhabditis elegans.
Characterization of GAR-2, a novel G protein-linked acetylcholine receptor from Caenorhabditis elegans.
Genetic and cellular basis for acetylcholine inhibition of Caenorhabditis elegans egg-laying behavior.
Three functional isoforms of GAR-2, a Caenorhabditis elegans G-protein-linked acetylcholine receptor, are produced by alternative splicing.
TAF-4 is required for the life extension of isp-1, clk-1 and tpk-1 Mit mutants.
Computer simulations and image processing reveal length-dependent pulling force as the primary mechanism for C. elegans male pronuclear migration.
Crystal structure of a TOG domain: conserved features of XMAP215/Dis1-family TOG domains and implications for tubulin binding.
Dissection of cell division processes in the one cell stage Caenorhabditis elegans embryo by mutational analysis.
Generation of asymmetry and segregation of germ-line granules in early C. elegans embryos.
Lifespan shortening of the nematode Caenorhabditis elegans under higher concentrations of oxygen.
Mutations affecting the meiotic and mitotic divisions of the early Caenorhabditis elegans embryo.
Parental effects and phenotypic characterization of mutations that affect early development in Caenorhabditis elegans.
Two loci required for cytoplasmic organization in early embryos of Caenorhabditis elegans.
ZYG-9, a Caenorhabditis elegans protein required for microtubule organization and function, is a component of meiotic and mitotic spindle poles.
Differential impact of the HEN1 homolog HENN-1 on 21U and 26G RNAs in the germline of Caenorhabditis elegans.
PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1.
Conserved aromatic and basic amino acid residues in the pore region of Caenorhabditis elegans spastin play critical roles in microtubule severing.
Conserved pharmacological rescue of hereditary spastic paraplegia-related phenotypes across model organisms.
Dynamic microtubules drive circuit rewiring in the absence of neurite remodeling.
Spastin binds to lipid droplets and affects lipid metabolism.
Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin.
The C-terminal alpha-helix of SPAS-1, a Caenorhabditis elegans spastin homologue, is crucial for microtubule severing.
The C. elegans homologue of the spastic paraplegia protein, spastin, disassembles microtubules.
Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer.
RAB-11 permissively regulates spindle alignment by modulating metaphase microtubule dynamics in Caenorhabditis elegans early embryos.
RAB-5- and RAB-11-dependent vesicle-trafficking pathways are required for plasma membrane repair after attack by bacterial pore-forming toxin.
RACK-1 directs dynactin-dependent RAB-11 endosomal recycling during mitosis in Caenorhabditis elegans.
Rab11 is required for synchronous secretion of chondroitin proteoglycans after fertilization in Caenorhabditis elegans.
Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME-4, a coated-pit protein.
HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling.
Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling.
Gut-specific and developmental expression of a Caenorhabditis elegans cysteine protease gene.
Regulation of the Caenorhabditis elegans gut cysteine protease gene cpr-1: requirement for GATA motifs.
A Large Family of Enzymes Responsible for the Modular Architecture of Nematode Pheromones.
Biosynthesis of Modular Ascarosides in C. elegans.
A novel adapter protein employs a phosphotyrosine binding domain and exceptionally basic N-terminal domains to capture and localize an atypical protein kinase C: characterization of Caenorhabditis elegans C kinase adapter 1, a protein that avidly binds protein kinase C3.
Structural properties and mechanisms that govern association of C kinase adapter 1 with protein kinase C3 and the cell periphery.
Structure, expression, and properties of an atypical protein kinase C (PKC3) from Caenorhabditis elegans. PKC3 is required for the normal progression of embryogenesis and viability of the organism.
C. elegans mig-6 encodes papilin isoforms that affect distinct aspects of DTC migration, and interacts genetically with mig-17 and collagen IV.
Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases.
Kinesin light chain isoforms in Caenorhabditis elegans.
Role of synaptic phosphatidylinositol 3-kinase in a behavioral learning response in C. elegans.
An N-myristoylated globin with a redox-sensing function that regulates the defecation cycle in Caenorhabditis elegans.
Electron transfer function versus oxygen delivery: a comparative study for several hexacoordinated globins across the animal kingdom.
The Caenorhabditis elegans UNC-87 protein is essential for maintenance, but not assembly, of bodywall muscle.
The Caenorhabditis elegans muscle-affecting gene unc-87 encodes a novel thin filament-associated protein.
UNC-87 isoforms, Caenorhabditis elegans calponin-related proteins, interact with both actin and myosin and regulate actomyosin contractility.
Family of neural wiring receptors in bilaterians defined by phylogenetic, biochemical, and structural evidence.
A Genome-Wide RNAi Screen for Factors Involved in Neuronal Specification in Caenorhabditis elegans.
cdh-3, a gene encoding a member of the cadherin superfamily, functions in epithelial cell morphogenesis in Caenorhabditis elegans.
A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans.
Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome.
A Cytoplasmic Argonaute Protein Promotes the Inheritance of RNAi.
NRA-2, a nicalin homolog, regulates neuronal death by controlling surface localization of toxic Caenorhabditis elegans DEG/ENaC channels.
tcl-2 encodes a novel protein that acts synergistically with Wnt signaling pathways in C. elegans.
Neuronal polarity is regulated by a direct interaction between a scaffolding protein, Neurabin, and a presynaptic SAD-1 kinase in Caenorhabditis elegans.
The SAD-1 kinase regulates presynaptic vesicle clustering and axon termination.
A novel alpha1,2-fucosyltransferase (CE2FT-2) in Caenorhabditis elegans generates H-type 3 glycan structures.
Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes.
A role for RIC-8 (Synembryn) and GOA-1 (G(o)alpha) in regulating a subset of centrosome movements during early embryogenesis in Caenorhabditis elegans.
Control of embryonic spindle positioning and Galpha activity by C. elegans RIC-8.
Convergent, RIC-8-dependent Galpha signaling pathways in the Caenorhabditis elegans synaptic signaling network.
Cortical localization of the Galpha protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division.
Mutations that rescue the paralysis of Caenorhabditis elegans ric-8 (synembryn) mutants activate the G alpha(s) pathway and define a third major branch of the synaptic signaling network.
RGS-7 completes a receptor-independent heterotrimeric G protein cycle to asymmetrically regulate mitotic spindle positioning in C. elegans.
RIC-8 (Synembryn): a novel conserved protein that is required for Gq alpha signaling in the C. elegans nervous system.
RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos.
A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity.
Regulation of anoxic death in Caenorhabditis elegans by mammalian apoptosis signal-regulating kinase (ASK) family proteins.
SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans.
Stabilization of RNT-1 protein, runt-related transcription factor (RUNX) protein homolog of Caenorhabditis elegans, by oxidative stress through mitogen-activated protein kinase pathway.
BIR-1, a Caenorhabditis elegans homologue of Survivin, regulates transcription and development.
BIR-1, the homologue of human Survivin, regulates expression of developmentally active collagen genes in C. elegans.
Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis.
C. elegans DPY-19 is a C-mannosyltransferase glycosylating thrombospondin repeats.
Establishment of left/right asymmetry in neuroblast migration by UNC-40/DCC, UNC-73/Trio and DPY-19 proteins in C. elegans.
A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.
Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents.
Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2.
PTRN-1, a microtubule minus end-binding CAMSAP homolog, promotes microtubule function in Caenorhabditis elegans neurons.
The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites.
The microtubule minus-end-binding protein patronin/PTRN-1 is required for axon regeneration in C. elegans.
Zinc ions and cation diffusion facilitator proteins regulate Ras-mediated signaling.
Aspartic proteases from the nematode Caenorhabditis elegans. Structural organization and developmental and cell-specific expression of asp-1.
NAD+ cleavage activity by animal and plant TIR domains in cell death pathways.
Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response.
SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation.
Studies of SARM1 uncover similarities between immune and neuronal responses to danger.
The maintenance of neuromuscular function requires UBC-25 in Caenorhabditis elegans.
A dynamin GTPase mutation causes a rapid and reversible temperature-inducible locomotion defect in C. elegans.
Supplementary nuclear receptor NHR-60 is required for normal embryonic and early larval development of Caenorhabditis elegans.
Characterization of the C. elegans gap-2 gene encoding a novel Ras-GTPase activating protein and its possible role in larval development.
The DEP domain-containing protein TOE-2 promotes apoptosis in the Q lineage of C. elegans through two distinct mechanisms.
RNA helicase A is important for germline transcriptional control, proliferation, and meiosis in C. elegans.
Caenorhabditis elegans SMG-2 selectively marks mRNAs containing premature translation termination codons.
Actin gene family of Caenorhabditis elegans.
Wild-type and mutant actin genes in Caenorhabditis elegans.
Molecular basis for galactosylation of core fucose residues in invertebrates: identification of caenorhabditis elegans N-glycan core alpha1,6-fucoside beta1,4-galactosyltransferase GALT-1 as a member of a novel glycosyltransferase family.
Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity.
Functional genomic approach to identify novel genes involved in the regulation of oxidative stress resistance and animal lifespan.
Erroneous ribosomal RNAs promote the generation of antisense ribosomal siRNA.
HLH-14 is a C. elegans achaete-scute protein that promotes neurogenesis through asymmetric cell division.
Sequence comparison between the flavoprotein subunit of the fumarate reductase (complex II) of the anaerobic parasitic nematode, Ascaris suum and the succinate dehydrogenase of the aerobic, free-living nematode, Caenorhabditis elegans.
The C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb pathway.
The Caenorhabditis elegans gene, gly-2, can rescue the N-acetylglucosaminyltransferase V mutation of Lec4 cells.
The mup-4 locus in Caenorhabditis elegans is essential for hypodermal integrity, organismal morphogenesis and embryonic body wall muscle position.
The Caenorhabditis elegans homologue of the extracellular calcium binding protein SPARC/osteonectin affects nematode body morphology and mobility.
An amiloride-sensitive H+-gated Na+ channel in Caenorhabditis elegans body wall muscle cells.
C. elegans unc-105 mutations affect muscle and are suppressed by other mutations that affect muscle.
Interaction between a putative mechanosensory membrane channel and a collagen.
Mutations with dominant effects on the behavior and morphology of the nematode Caenorhabditis elegans.
Patch clamp study of the UNC-105 degenerin and its interaction with the LET-2 collagen in Caenorhabditis elegans muscle.
The nematode degenerin UNC-105 forms ion channels that are activated by degeneration- or hypercontraction-causing mutations.
A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans.
Dietary restriction induced longevity is mediated by nuclear receptor NHR-62 in Caenorhabditis elegans.
MTD-1, a touch-cell-specific membrane protein with a subtle effect on touch sensitivity.
A new pathway for heavy metal detoxification in animals. Phytochelatin synthase is required for cadmium tolerance in Caenorhabditis elegans.
Deletion of Phytochelatin Synthase Modulates the Metal Accumulation Pattern of Cadmium Exposed C. elegans.
Detoxification of multiple heavy metals by a half-molecule ABC transporter, HMT-1, and coelomocytes of Caenorhabditis elegans.
Metalloproteins and phytochelatin synthase may confer protection against zinc oxide nanoparticle induced toxicity in Caenorhabditis elegans.
Local F-actin network links synapse formation and axon branching.
The immunoglobulin superfamily protein SYG-1 determines the location of specific synapses in C. elegans.
Stochastic loss and gain of symmetric divisions in the C. elegans epidermis perturbs robustness of stem cell number.
The role of lin-22, a hairy/enhancer of split homolog, in patterning the peripheral nervous system of C. elegans.
Active chromatin marks drive spatial sequestration of heterochromatin in C. elegans nuclei.
Perinuclear anchoring of H3K9-methylated chromatin stabilizes induced cell fate in C. elegans embryos.
The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes.
C. elegans mutant identification with a one-step whole-genome-sequencing and SNP mapping strategy.
Control of C. elegans hermaphrodite gonad size and shape by vab-3/Pax6-mediated regulation of integrin receptors.
Genetic analysis of the Caenorhabditis elegans pax-6 locus: roles of paired domain-containing and nonpaired domain-containing isoforms.
Mutations in the Caenorhabditis elegans gene vab-3 reveal distinct roles in fate specification and unequal cytokinesis in an asymmetric cell division.
Pattern formation in the nematode epidermis: determination of the arrangement of peripheral sense organs in the C. elegans male tail.
Patterning of the Caenorhabditis elegans head region by the Pax-6 family member vab-3.
Positive and negative regulatory inputs restrict pax-6/vab-3 transcription to sensory organ precursors in Caenorhabditis elegans.
Regulated nuclear entry of the C. elegans Pax-6 transcription factor.
Specification of sense-organ identity by a Caenorhabditis elegans Pax-6 homologue.
The Caenorhabditis elegans Six/sine oculis class homeobox gene ceh-32 is required for head morphogenesis.
mls-2 and vab-3 Control glia development, hlh-17/Olig expression and glia-dependent neurite extension in C. elegans.
An essential role in molting and morphogenesis of Caenorhabditis elegans for ACN-1, a novel member of the angiotensin-converting enzyme family that lacks a metallopeptidase active site.
Angiotensin converting enzyme (ACE) inhibitor extends Caenorhabditis elegans life span.
Caenorhabditis elegans homologue of the human azoospermia factor DAZ is required for oogenesis but not for spermatogenesis.
Characterization of a tyramine receptor from Caenorhabditis elegans.
Nematicidal activity of two monoterpenoids and SER-2 tyramine receptor of Caenorhabditis elegans.
Cyclophilin and protein disulfide isomerase genes are co-transcribed in a functionally related manner in Caenorhabditis elegans.
Characterization of the C. elegans erlin homologue.
Cyclin E and CDK-2 regulate proliferative cell fate and cell cycle progression in the C. elegans germline.
Cyclin E expression during development in Caenorhabditis elegans.
Mutations in cye-1, a Caenorhabditis elegans cyclin E homolog, reveal coordination between cell-cycle control and vulval development.
Translational repression of cyclin E prevents precocious mitosis and embryonic gene activation during C. elegans meiosis.
A chromatin modifier integrates insulin/IGF-1 signalling and dietary restriction to regulate longevity.
A conserved PHD finger protein and endogenous RNAi modulate insulin signaling in Caenorhabditis elegans.
Neuronal migration is regulated by endogenous RNAi and chromatin-binding factor ZFP-1/AF10 in Caenorhabditis elegans.
The conserved PHD1-PHD2 domain of ZFP-1/AF10 is a discrete functional module essential for viability in Caenorhabditis elegans.
The insulin/IGF signaling regulators cytohesin/GRP-1 and PIP5K/PPK-1 modulate susceptibility to excitotoxicity in C. elegans.
Genetic and molecular characterization of the Caenorhabditis elegans gene, mel-26, a postmeiotic negative regulator of mei-1, a meiotic-specific spindle component.
KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing.
SQV-7, a protein involved in Caenorhabditis elegans epithelial invagination and early embryogenesis, transports UDP-glucuronic acid, UDP-N-acetylgalactosamine, and UDP-galactose.
Thiamine pyrophosphate biosynthesis and transport in the nematode Caenorhabditis elegans.
A Caenorhabditis elegans model of orotic aciduria reveals enlarged lysosome-related organelles in embryos lacking umps-1 function.
The Caenorhabditis elegans unc-32 gene encodes alternative forms of a vacuolar ATPase a subunit.
Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans.
APEASPFIRFamide, a novel FMRFamide-related decapeptide from Caenorhabditis elegans: structure and myoactivity.
smg-7 is required for mRNA surveillance in Caenorhabditis elegans.
Modification of epidermal growth factor-like repeats with O-fucose: molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase.
Structural insights into the mechanism of protein O-fucosylation.
Germ-line regulation of the Caenorhabditis elegans sex-determining gene tra-2.
Molecular analysis of tra-2, a sex determining gene in C.elegans.
tra-2 encodes a membrane protein and may mediate cell communication in the Caenorhabditis elegans sex determination pathway.
A gene required for nuclear and mitochondrial attachment in the nematode Caenorhabditis elegans.
A genetic approach to study the role of nuclear envelope components in nuclear positioning.
Neural maintenance roles for the matrix receptor dystroglycan and the nuclear anchorage complex in Caenorhabditis elegans.
Role of ANC-1 in tethering nuclei to the actin cytoskeleton.
The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.
UNC-84 localizes to the nuclear envelope and is required for nuclear migration and anchoring during C. elegans development.
Cis- and trans-regulatory mechanisms of gene expression in the ASJ sensory neuron of Caenorhabditis elegans.
MOS2, a protein containing G-patch and KOW motifs, is essential for innate immunity in Arabidopsis thaliana.
The Caenorhabditis elegans unc-63 gene encodes a levamisole-sensitive nicotinic acetylcholine receptor alpha subunit.
The Caenorhabditis elegans p120 catenin homologue, JAC-1, modulates cadherin-catenin function during epidermal morphogenesis.
CHL-1 provides an essential function affecting cell proliferation and chromosome stability in Caenorhabditis elegans.
Cloning and characterization of a Caenorhabditis elegans D2-like dopamine receptor.
DOP-2 D2-Like Receptor Regulates UNC-7 Innexins to Attenuate Recurrent Sensory Motor Neurons during C. elegans Copulation.
Tetraspanin (TSP-17) protects dopaminergic neurons against 6-OHDA-induced neurodegeneration in C. elegans.
Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells.
Genetic identification, sequence, and alternative splicing of the Caenorhabditis elegans alpha 2(IV) collagen gene.
Mutations in the alpha 2(IV) basement membrane collagen gene of Caenorhabditis elegans produce phenotypes of differing severities.
ATX-2, the C. elegans ortholog of human Ataxin-2, regulates centrosome size and microtubule dynamics.
The C. elegans zyg-1 gene encodes a regulator of centrosome duplication with distinct maternal and paternal roles in the embryo.
Identification of Caenorhabditis elegans isovaleryl-CoA dehydrogenase and structural comparison with other acyl-CoA dehydrogenases.
Evidence that RME-1, a conserved C. elegans EH-domain protein, functions in endocytic recycling.
cDNA cloning and genomic organization of enhancer of split groucho gene from nematode Caenorhabditis elegans.
Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol.
Depletion of mboa-7, an enzyme that incorporates polyunsaturated fatty acids into phosphatidylinositol (PI), impairs PI 3-phosphate signaling in Caenorhabditis elegans.
MRG-1 is required for both chromatin-based transcriptional silencing and genomic integrity of primordial germ cells in Caenorhabditis elegans.
MRG-1 is required for genomic integrity in Caenorhabditis elegans germ cells.
MRG-1, a mortality factor-related chromodomain protein, is required maternally for primordial germ cells to initiate mitotic proliferation in C. elegans.
MRG-1, an autosome-associated protein, silences X-linked genes and protects germline immortality in Caenorhabditis elegans.
MRG-1/MRG15 Is a Barrier for Germ Cell to Neuron Reprogramming in Caenorhabditis elegans.
Proteasome regulation of the chromodomain protein MRG-1 controls the balance between proliferative fate and differentiation in the C. elegans germ line.
The chromodomain protein MRG-1 facilitates SC-independent homologous pairing during meiosis in Caenorhabditis elegans.
Alternative trans-splicing of Caenorhabditis elegans sma-9/schnurri generates a short transcript that provides tissue-specific function in BMP signaling.
An antagonistic role for the C. elegans Schnurri homolog SMA-9 in modulating TGFbeta signaling during mesodermal patterning.
SMAD Transcription Factor, Sma-9, Attunes TGF-beta Signaling Cascade Towards Modulating Amyloid Beta Aggregation and Associated Outcome in Transgenic C. elegans.
The Caenorhabditis elegans schnurri homolog sma-9 mediates stage- and cell type-specific responses to DBL-1 BMP-related signaling.
The forkhead transcription factor UNC-130/FOXD integrates both BMP and Notch signaling to regulate dorsoventral patterning of the C. elegans postembryonic mesoderm.
Transcriptional repressor and activator activities of SMA-9 contribute differentially to BMP-related signaling outputs.
Cell architecture: surrounding muscle cells shape gland cell morphology in the Caenorhabditis elegans pharynx.
Large isoforms of UNC-89 (obscurin) are required for muscle cell architecture and optimal calcium release in Caenorhabditis elegans.
Structure of a PH domain from the C. elegans muscle protein UNC-89 suggests a novel function.
The Caenorhabditis elegans gene unc-89, required for muscle M-line assembly, encodes a giant modular protein composed of Ig and signal transduction domains.
The SH3 domain of UNC-89 (obscurin) interacts with paramyosin, a coiled-coil protein, in Caenorhabditis elegans muscle.
Three new isoforms of Caenorhabditis elegans UNC-89 containing MLCK-like protein kinase domains.
Titin/connectin-related proteins in C. elegans: a review and new findings.
Genes critical for muscle development and function in Caenorhabditis elegans identified through lethal mutations.
Talin loss-of-function uncovers roles in cell contractility and migration in C. elegans.
RAD-6: pyrimidine synthesis and radiation sensitivity in Caenorhabditis elegans.
SAS-4 is a C. elegans centriolar protein that controls centrosome size.
SAS-4 is essential for centrosome duplication in C. elegans and is recruited to daughter centrioles once per cell cycle.
Ubiquitin-dependent regulation of a conserved DMRT protein controls sexually dimorphic synaptic connectivity and behavior.
A new DNA-binding motif in the Skn-1 binding domain-DNA complex.
Formation of a monomeric DNA binding domain by Skn-1 bZIP and homeodomain elements.
skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo.
The forkhead domain gene unc-130 generates chemosensory neuron diversity in C. elegans.
MEL-47, a novel protein required for early cell divisions in the nematode Caenorhabditis elegans.
C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression.
The Caenorhabditis elegans gene T23G5.5 encodes an antidepressant- and cocaine-sensitive dopamine transporter.
Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells.
Cap-independent translation promotes C. elegans germ cell apoptosis through Apaf-1/CED-4 in a caspase-dependent mechanism.
Regulation of CED-3 caspase localization and activation by C. elegans nuclear-membrane protein NPP-14.
The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme.
The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.
Multiple signaling mechanisms of the UNC-6/netrin receptors UNC-5 and UNC-40/DCC in vivo.
UNC-6/Netrin induces neuronal asymmetry and defines the site of axon formation.
FEM1 proteins are ancient regulators of SLBP degradation.
The gene for histone RNA hairpin binding protein is located on human chromosome 4 and encodes a novel type of RNA binding protein.
The stem-loop binding protein CDL-1 is required for chromosome condensation, progression of cell death and morphogenesis in Caenorhabditis elegans.
Environmental responsiveness of tubulin glutamylation in sensory cilia is regulated by the p38 MAPK pathway.
Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.
A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans.
An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis.
Lipid metabolic sensors of MDT-15 and SBP-1 regulated the response to simulated microgravity in the intestine of Caenorhabditis elegans.
A novel role for the zinc-finger transcription factor EGL-46 in the differentiation of gas-sensing neurons in Caenorhabditis elegans.
Caenorhabditis elegans UBC-2 functions with the anaphase-promoting complex but also has other activities.
The coronin-like protein POD-1 is required for anterior-posterior axis formation and cellular architecture in the nematode caenorhabditis elegans.
Evolutionary conserved role for TARPs in the gating of glutamate receptors and tuning of synaptic function.
Analysis of Ca2+ signaling motifs that regulate proton signaling through the Na+/H+ exchanger NHX-7 during a rhythmic behavior in Caenorhabditis elegans.
Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway.
The C. elegans H3K27 demethylase UTX-1 is essential for normal development, independent of its enzymatic activity.
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development.
ZSP-1 is a Z granule surface protein required for Z granule fluidity and germline immortality in Caenorhabditis elegans.
FLR-4, a novel serine/threonine protein kinase, regulates defecation rhythm in Caenorhabditis elegans.
DRE-1: an evolutionarily conserved F box protein that regulates C. elegans developmental age.
The SCF FSN-1 ubiquitin ligase controls germline apoptosis through CEP-1/p53 in C. elegans.
The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters.
The Caenorhabditis elegans sex determination gene mog-1 encodes a member of the DEAH-Box protein family.
Dendrites with specialized glial attachments develop by retrograde extension using SAX-7 and GRDN-1.
A novel type of RNase III family proteins in eukaryotes.
Processing of primary microRNAs by the Microprocessor complex.
Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene.
A conserved phosphorylation switch controls the interaction between cadherin and beta-catenin in vitro and in vivo.
A putative catenin-cadherin system mediates morphogenesis of the Caenorhabditis elegans embryo.
An E-cadherin-mediated hitchhiking mechanism for C. elegans germ cell internalization during gastrulation.
In vitro and in vivo reconstitution of the cadherin-catenin-actin complex from Caenorhabditis elegans.
SAX-7/L1CAM and HMR-1/cadherin function redundantly in blastomere compaction and non-muscle myosin accumulation during Caenorhabditis elegans gastrulation.
The C. elegans hmr-1 gene can encode a neuronal classic cadherin involved in the regulation of axon fasciculation.
Effects of voltage-gated calcium channel subunit genes on calcium influx in cultured C. elegans mechanosensory neurons.
Genes affecting sensitivity to serotonin in Caenorhabditis elegans.
Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development.
Expression and phenotype analysis of the nephrocystin-1 and nephrocystin-4 homologs in Caenorhabditis elegans.
Memory in Caenorhabditis elegans is mediated by NMDA-type ionotropic glutamate receptors.
Uncoupling the Trade-Off between Somatic Proteostasis and Reproduction in Caenorhabditis elegans Models of Polyglutamine Diseases.
omega-6 Polyunsaturated fatty acids extend life span through the activation of autophagy.
Caenorhabditis elegans SID-2 is required for environmental RNA interference.
C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues.
AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans.
The bHLH-PAS gene hlh-34 is expressed in the AVH, not AVJ interneurons.
Identification of a mouse protein whose homolog in Saccharomyces cerevisiae is a component of the CCR4 transcriptional regulatory complex.
Facilitation of synaptic transmission by EGL-30 Gqalpha and EGL-8 PLCbeta: DAG binding to UNC-13 is required to stimulate acetylcholine release.
Goalpha and diacylglycerol kinase negatively regulate the Gqalpha pathway in C. elegans.
Inositol 1,4,5-trisphosphate signaling regulates mating behavior in Caenorhabditis elegans males.
Inositol 1,4,5-trisphosphate signalling regulates the avoidance response to nose touch in Caenorhabditis elegans.
CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.
Independent domains of the Sdc-3 protein control sex determination and dosage compensation in C. elegans.
SUMOylation is essential for sex-specific assembly and function of the Caenorhabditis elegans dosage compensation complex on X chromosomes.
Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression in Caenorhabditis elegans.
Anterior organization of the Caenorhabditis elegans embryo by the labial-like Hox gene ceh-13.
Purification and characterization of Caenorhabditis elegans NTH, a homolog of human endonuclease III: essential role of N-terminal region.
The relative roles of three DNA repair pathways in preventing Caenorhabditis elegans mutation accumulation.
A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans.
The EGR family gene egrh-1 functions non-autonomously in the control of oocyte meiotic maturation and ovulation in C. elegans.
Structural and Functional Analysis of Nonheme Iron Enzymes BCMO-1 and BCMO-2 from Caenorhabditis elegans.
Genetic control of differentiation of the Caenorhabditis elegans touch receptor neurons.
Identification of genes expressed in C. elegans touch receptor neurons.
The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation.
Axon guidance genes identified in a large-scale RNAi screen using the RNAi-hypersensitive Caenorhabditis elegans strain nre-1(hd20) lin-15b(hd126).
Identification of an endo-beta-N-acetylglucosaminidase gene in Caenorhabditis elegans and its expression in Escherichia coli.
The C. elegans HGF/plasminogen-like protein SVH-1 has protease-dependent and -independent functions.
The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans.
Evidence for evolutionary conservation of sex-determining genes.
A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans.
C elegans: a model for exploring the genetics of fat storage.
Essential role of SBP-1 activation in oxygen deprivation induced lipid accumulation and increase in body width/length ratio in Caenorhabditis elegans.
Fat accumulation in Caenorhabditis elegans is mediated by SREBP homolog SBP-1.
Zinc mediates the SREBP-SCD axis to regulate lipid metabolism in Caenorhabditis elegans.
Caenorhabditis elegans contains a third polo-like kinase gene.
Polo kinases establish links between meiotic chromosomes and cytoskeletal forces essential for homolog pairing.
C. elegans EOR-1/PLZF and EOR-2 positively regulate Ras and Wnt signaling and function redundantly with LIN-25 and the SUR-2 Mediator component.
sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction.
SYP-3 restricts synaptonemal complex assembly to bridge paired chromosome axes during meiosis in Caenorhabditis elegans.
Synaptonemal Complex Components Are Required for Meiotic Checkpoint Function in Caenorhabditis elegans.
C. elegans NIMA-related kinases NEKL-2 and NEKL-3 are required for the completion of molting.
C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180.
The nematode leucine-rich repeat-containing, G protein-coupled receptor (LGR) protein homologous to vertebrate gonadotropin and thyrotropin receptors is constitutively active in mammalian cells.
The structure of nonvertebrate actin: implications for the ATP hydrolytic mechanism.
end-1 encodes an apparent GATA factor that specifies the endoderm precursor in Caenorhabditis elegans embryos.
The BED finger domain protein MIG-39 halts migration of distal tip cells in Caenorhabditis elegans.
Regulation of nicotinic receptor trafficking by the transmembrane Golgi protein UNC-50.
UNCL, the mammalian homologue of UNC-50, is an inner nuclear membrane RNA-binding protein.
An ion channel of the degenerin/epithelial sodium channel superfamily controls the defecation rhythm in Caenorhabditis elegans.
A natural variant and engineered mutation in a GPCR promote DEET resistance in C. elegans.
A quantitative targeted proteomics approach to validate predicted microRNA targets in C. elegans.
The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA.
Embryonic morphogenesis in Caenorhabditis elegans integrates the activity of LET-502 Rho-binding kinase, MEL-11 myosin phosphatase, DAF-2 insulin receptor and FEM-2 PP2c phosphatase.
Rho-binding kinase (LET-502) and myosin phosphatase (MEL-11) regulate cytokinesis in the early Caenorhabditis elegans embryo.
The RhoGAP RGA-2 and LET-502/ROCK achieve a balance of actomyosin-dependent forces in C. elegans epidermis to control morphogenesis.
ASB-1, a germline-specific isoform of mitochondrial ATP synthase b subunit, is required to maintain the rate of germline development in Caenorhabditis elegans.
The C. elegans M3 neuron guides the growth cone of its sister cell M2 via the Krueppel-like zinc finger protein MNM-2.
IRK-1 potassium channels mediate peptidergic inhibition of Caenorhabditis elegans serotonin neurons via a G(o) signaling pathway.
A newly formed telomere in Ascaris suum does not exert a telomere position effect on a nearby gene.
Both chromosome decondensation and condensation are dependent on DNA replication in C. elegans embryos.
Identification of conserved MEL-28/ELYS domains with essential roles in nuclear assembly and chromosome segregation.
Essential roles of 3'-phosphoadenosine 5'-phosphosulfate synthase in embryonic and larval development of the nematode Caenorhabditis elegans.
eor-1 and eor-2 are required for cell-specific apoptotic death in C. elegans.
Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA-2A.
Molecular characterization of the her-1 gene suggests a direct role in cell signaling during Caenorhabditis elegans sex determination.
Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction.
Role of a new Rho family member in cell migration and axon guidance in C. elegans.
Structural genomics of Caenorhabditis elegans: crystal structure of the tropomodulin C-terminal domain.
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans.
Correction: Neuroendocrine modulation sustains the C. elegans forward motor state.
UNC-39, the C. elegans homolog of the human myotonic dystrophy-associated homeodomain protein Six5, regulates cell motility and differentiation.
C. elegans MCM-4 is a general DNA replication and checkpoint component with an epidermis-specific requirement for growth and viability.
UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans.
Posterior pattern formation in C. elegans involves position-specific expression of a gene containing a homeobox.
Requirement of V-ATPase for ovulation and embryogenesis in Caenorhabditis elegans.
Identification of genes involved in the ciliary trafficking of C. elegans PKD-2.
The CIL-1 PI 5-phosphatase localizes TRP polycystins to cilia and activates sperm in C. elegans.
HEN-1, a secretory protein with an LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans.
Mitochondrial UPR repression during Pseudomonas aeruginosa infection requires the bZIP protein ZIP-3.
The Rho/Rac family guanine nucleotide exchange factor VAV-1 regulates rhythmic behaviors in Caenorhabditis elegans.
Identification of a Caenorhabditis elegans histone H1 gene family. Characterization of a family member containing an intron and encoding a poly(A)+ mRNA.
The primary structure of the major isoform (H1.1) of histone H1 from the nematode Caenorhabditis elegans.
Conserved initiator proteins in eukaryotes.
A role for dynein in the inhibition of germ cell proliferative fate.
METT-10, a putative methyltransferase, inhibits germ cell proliferative fate in Caenorhabditis elegans.
A conserved function of C. elegans CASY-1 calsyntenin in associative learning.
CASY-1, an ortholog of calsyntenins/alcadeins, is essential for learning in Caenorhabditis elegans.
Regulation of glutamate signaling in the sensorimotor circuit by CASY-1A/calsyntenin in Caenorhabditis elegans.
The C-terminal of CASY-1/Calsyntenin regulates GABAergic synaptic transmission at the Caenorhabditis elegans neuromuscular junction.
A neuromedin-pyrokinin-like neuropeptide signaling system in Caenorhabditis elegans.
The glyceraldehyde-3-phosphate dehydrogenase gene family in the nematode, Caenorhabditis elegans: isolation and characterization of one of the genes.
Role of the C. elegans U2 snRNP protein MOG-2 in sex determination, meiosis, and splice site selection.
The nicotinic acetylcholine receptor gene family of the nematode Caenorhabditis elegans: an update on nomenclature.
Glutamine/proline-rich PQE-1 proteins protect Caenorhabditis elegans neurons from huntingtin polyglutamine neurotoxicity.
Mutations in the pqe-1 gene enhance transgene expression in Caenorhabditis elegans.
The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis.
A genetic screen for temperature-sensitive cell-division mutants of Caenorhabditis elegans.
Chromosome movements promoted by the mitochondrial protein SPD-3 are required for homology search during Caenorhabditis elegans meiosis.
SPD-3 is required for spindle alignment in Caenorhabditis elegans embryos and localizes to mitochondria.
Periodic charge distributions in the myosin rod amino acid sequence match cross-bridge spacings in muscle.
The genes sup-7 X and sup-5 III of C. elegans suppress amber nonsense mutations via altered transfer RNA.
A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes.
GCNA Preserves Genome Integrity and Fertility Across Species.
SUMOylation promotes protective responses to DNA-protein cross-links.
The C. elegans LAR-like receptor tyrosine phosphatase PTP-3 and the VAB-1 Eph receptor tyrosine kinase have partly redundant functions in morphogenesis.
Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain.
Regulation of the UNC-5 netrin receptor initiates the first reorientation of migrating distal tip cells in Caenorhabditis elegans.
UNC-5 function requires phosphorylation of cytoplasmic tyrosine 482, but its UNC-40-independent functions also require a region between the ZU-5 and death domains.
UNC-5, a transmembrane protein with immunoglobulin and thrombospondin type 1 domains, guides cell and pioneer axon migrations in C. elegans.
Interplay between structure-specific endonucleases for crossover control during Caenorhabditis elegans meiosis.
SLX-1 is required for maintaining genomic integrity and promoting meiotic noncrossovers in the Caenorhabditis elegans germline.
RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans.
A Caenorhabditis elegans PUF protein family with distinct RNA binding specificity.
Identification and characterization of Caenorhabditis elegans palmitoyl protein thioesterase1.
Loss and gain of domains during evolution of cut superclass homeobox genes.
Inositol monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans.
Temperature sensing by an olfactory neuron in a circuit controlling behavior of C. elegans.
The Caenorhabditis elegans hsp70 gene family: a molecular genetic characterization.
Similarity of sli-1, a regulator of vulval development in C. elegans, to the mammalian proto-oncogene c-cbl.
A gene affecting production of the Caenorhabditis elegans dauer-inducing pheromone.
A second isoform of 3-ketoacyl-CoA thiolase found in Caenorhabditis elegans which is similar to sterol carrier protein x but lacks the sequence of sterol carrier protein 2.
Biosynthesis of the Caenorhabditis elegans dauer pheromone.
Caenorhabditis elegans utilizes dauer pheromone biosynthesis to dispose of toxic peroxisomal fatty acids for cellular homoeostasis.
Molecular cloning and sequencing of ama-1, the gene encoding the largest subunit of Caenorhabditis elegans RNA polymerase II.
cdk-7 is required for mRNA transcription and cell cycle progression in Caenorhabditis elegans embryos.
A putative GDP-GTP exchange factor is required for development of the excretory cell in Caenorhabditis elegans.
The Caenorhabditis elegans homolog of FGD1, the human Cdc42 GEF gene responsible for faciogenital dysplasia, is critical for excretory cell morphogenesis.
Phosphatidylinositol 4,5-bisphosphate and loss of PLCgamma activity inhibit TRPM channels required for oscillatory Ca2+ signaling.
Sensory perception of food and insulin-like signals influence seizure susceptibility.
The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction.
CRA-1 uncovers a double-strand break-dependent pathway promoting the assembly of central region proteins on chromosome axes during C. elegans meiosis.
NatB domain-containing cra-1 antagonizes hydrolase acer-1 linking acetyl-CoA metabolism to the initiation of recombination during C. elegans meiosis.
Genesis of an organ: molecular analysis of the pha-1 gene.
pha-1, a selectable marker for gene transfer in C. elegans.
Semaphorin 1a and semaphorin 1b are required for correct epidermal cell positioning and adhesion during morphogenesis in C. elegans.
Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model.
The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein.
The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction.
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans.
Identification of CHE-13, a novel intraflagellar transport protein required for cilia formation.
C. elegans telomeres contain G-strand and C-strand overhangs that are bound by distinct proteins.
Caenorhabditis elegans POT-1 and POT-2 repress telomere maintenance pathways.
Asymmetric arginine dimethylation modulates mitochondrial energy metabolism and homeostasis in Caenorhabditis elegans.
Functional genomic analysis of the let-7 regulatory network in Caenorhabditis elegans.
Characterization of STIP, a multi-domain nuclear protein, highly conserved in metazoans, and essential for embryogenesis in Caenorhabditis elegans.
Visualization of synaptic specializations in live C. elegans with synaptic vesicle protein-GFP fusions.
SFT-4/Surf4 control ER export of soluble cargo proteins and participate in ER exit site organization.
Surfeit locus gene homologs are widely distributed in invertebrate genomes.
DEX-1 and DYF-7 establish sensory dendrite length by anchoring dendritic tips during cell migration.
lon-1 regulates Caenorhabditis elegans body size downstream of the dbl-1 TGF beta signaling pathway.
Isolation, pharmacology and gene organization of KPSFVRFamide: a neuropeptide from Caenorhabditis elegans.
Characterization of beta pat-3 heterodimers, a family of essential integrin receptors in C. elegans.
par-1, atypical pkc, and PP2A/B55 sur-6 are implicated in the regulation of exocyst-mediated membrane trafficking in Caenorhabditis elegans.
cDNA cloning and expression of a C-terminus motor kinesin-like protein KLP-17, involved in chromosomal movement in Caenorhabditis elegans.
Caenorhabditis elegans UNC-96 is a new component of M-lines that interacts with UNC-98 and paramyosin and is required in adult muscle for assembly and/or maintenance of thick filaments.
Identification of genetic elements associated with muscle structure in the nematode Caenorhabditis elegans.
UNC-98 links an integrin-associated complex to thick filaments in Caenorhabditis elegans muscle.
The hedgehog-related gene qua-1 is required for molting in Caenorhabditis elegans.
Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation.
The POU gene ceh-18 promotes gonadal sheath cell differentiation and function required for meiotic maturation and ovulation in Caenorhabditis elegans.
Worms in space? A model biological dosimeter.
Membrane-associated collagens with interrupted triple-helices (MACITs): evolution from a bilaterian common ancestor and functional conservation in C. elegans.
Protein disulfide isomerase A6 controls the decay of IRE1alpha signaling via disulfide-dependent association.
Genetic interactions affecting touch sensitivity in Caenorhabditis elegans.
The F-box protein MEC-15 (FBXW9) promotes synaptic transmission in GABAergic motor neurons in C. elegans.
The nuclear receptor HIZR-1 uses zinc as a ligand to mediate homeostasis in response to high zinc.
C. elegans ten-1 is synthetic lethal with mutations in cytoskeleton regulators, and enhances many axon guidance defective mutants.
Caenorhabditis elegans teneurin, ten-1, is required for gonadal and pharyngeal basement membrane integrity and acts redundantly with integrin ina-1 and dystroglycan dgn-1.
ten-1, an essential gene for germ cell development, epidermal morphogenesis, gonad migration, and neuronal pathfinding in Caenorhabditis elegans.
CUTI-1: A novel tetraspan protein involved in C. elegans CUTicle formation and epithelial integrity.
Modulation of KSR activity in Caenorhabditis elegans by Zn ions, PAR-1 kinase and PP2A phosphatase.
SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans.
Soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling.
MES-2, a maternal protein essential for viability of the germline in Caenorhabditis elegans, is homologous to a Drosophila Polycomb group protein.
Shugoshin is essential for meiotic prophase checkpoints in C. elegans.
APC16 is a conserved subunit of the anaphase-promoting complex/cyclosome.
emb-1 encodes the APC16 subunit of the Caenorhabditis elegans anaphase-promoting complex.
Spermiogenesis initiation in Caenorhabditis elegans involves a casein kinase 1 encoded by the spe-6 gene.
The Caenorhabditis elegans spe-6 gene is required for major sperm protein assembly and shows second site non-complementation with an unlinked deficiency.
Coupling between endocytosis and sphingosine kinase 1 recruitment.
Localized sphingolipid signaling at presynaptic terminals is regulated by calcium influx and promotes recruitment of priming factors.
Recruitment of sphingosine kinase to presynaptic terminals by a conserved muscarinic signaling pathway promotes neurotransmitter release.
A molecular mechanism for the requirement of PAT-4 (integrin-linked kinase (ILK)) for the localization of UNC-112 (Kindlin) to integrin adhesion sites.
C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexes.
C. elegans PAT-6/actopaxin plays a critical role in the assembly of integrin adhesion complexes in vivo.
Integrin-linked kinase modulates longevity and thermotolerance in C. elegans through neuronal control of HSF-1.
Integrin-linked kinase regulates phosphorylation of serine 473 of protein kinase B by an indirect mechanism.
Suppressor mutations suggest a surface on PAT-4 (Integrin-linked Kinase) that interacts with UNC-112 (Kindlin).
UNC-97/PINCH is involved in the assembly of integrin cell adhesion complexes in Caenorhabditis elegans body wall muscle.
pat-4/ILK and unc-112/Mig-2 are required for gonad function in Caenorhabditis elegans.
Alternative splicing of gar-1, a Caenorhabditis elegans G-protein-linked acetylcholine receptor gene.
Cloning and expression of a G protein-linked acetylcholine receptor from Caenorhabditis elegans.
C. elegans secreted lipid-binding protein NRF-5 mediates PS appearance on phagocytes for cell corpse engulfment.
SPD-1 is required for the formation of the spindle midzone but is not essential for the completion of cytokinesis in C. elegans embryos.
Pseudosynapsis and decreased stringency of meiotic repair pathway choice on the hemizygous sex chromosome of Caenorhabditis elegans males.