9925:MCPH1
gene id: 9925:MCPH1
uniprot id: A0A452FFN6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.
messages: Interacts with CDC27 and maybe other components of the APC/C complex. Interacts with histone variant H2AX under DNA damage conditions.
messages: centrosome

9925:NNT
gene id: 9925:NNT
uniprot id: A0A452FLH3
names: Similarity
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

9925:RNF141
gene id: 9925:RNF141
uniprot id: A0A452EJQ4
names: Function
messages: May be involved in spermatogenesis.

9925:QPCTL
gene id: 9925:QPCTL
uniprot id: A0A452GBI6
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

9925:CROT
gene id: 9925:CROT
uniprot id: A0A452F0R6
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9925:GRP
gene id: 9925:GRP
uniprot id: A0A452E8M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Secreted
messages: neuron projection

9925:SFRP2
gene id: 9925:SFRP2
uniprot id: A0A452FQT2
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:IST1
gene id: 9925:IST1
uniprot id: A0A452DRI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IST1 family.
messages: Cytoplasmic vesicle
messages: Nucleus envelope

9925:LOC102190268
gene id: 9925:LOC102190268
uniprot id: A0A8C2NRN5
names: Similarity
messages: Belongs to the PRR23 family.

9925:MYO5B
gene id: 9925:MYO5B
uniprot id: A0A452EX31
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9925:ATP2A3
gene id: 9925:ATP2A3
uniprot id: A0A452F5S7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9925:NLRP3
gene id: 9925:NLRP3
uniprot id: A0A0A0UE95
names: Similarity
messages: Belongs to the NLRP family.

9925:LOC102173555
gene id: 9925:LOC102173555
uniprot id: A0A452EAZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102173863
gene id: 9925:LOC102173863
uniprot id: A0A452EZZ5
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102176015
gene id: 9925:LOC102176015
uniprot id: A0A452EM54
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.
messages: Mitochondrion inner membrane

9925:NFX1
gene id: 9925:NFX1
uniprot id: A0A452FCD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NFX1 family.
messages: Nucleus

9925:CDKL1
gene id: 9925:CDKL1
uniprot id: A0A452DXG6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:TRPC4
gene id: 9925:TRPC4
uniprot id: A0A452DT91
names: Subcellular Location Annotation
messages: Membrane

9925:ACSS1
gene id: 9925:ACSS1
uniprot id: A0A452FKE9
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9925:HVCN1
gene id: 9925:HVCN1
uniprot id: A0A8C2S470
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hydrogen channel family.
messages: Homodimer.
messages: Membrane

9925:RDH5
gene id: 9925:RDH5
uniprot id: A0A452EKV5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:LOC102183983
gene id: 9925:LOC102183983
uniprot id: A0A452FS80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9925:NECTIN4
gene id: 9925:NECTIN4
uniprot id: A0A452G371
names: Similarity
messages: Belongs to the nectin family.

9925:CCKAR
gene id: 9925:CCKAR
uniprot id: A0A452FXW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

9925:ATP23
gene id: 9925:ATP23
uniprot id: A0A452G7Q4
names: Similarity
messages: Belongs to the peptidase M76 family.

9925:SNX18
gene id: 9925:SNX18
uniprot id: A0A452FH19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9925:LOXL4
gene id: 9925:LOXL4
uniprot id: A0A452FSS6
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9925:LOC102180556
gene id: 9925:LOC102180556
uniprot id: A0A452ET78
names: Similarity
messages: Belongs to the serpin family.

9925:LOC102181793
gene id: 9925:LOC102181793
uniprot id: A0A452ELE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9925:NR6A1
gene id: 9925:NR6A1
uniprot id: A0A452FRH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9925:IGFBP6
gene id: 9925:IGFBP6
uniprot id: K9MM29
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:MSMP
gene id: 9925:MSMP
uniprot id: A0A452F297
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9925:PI4K2A
gene id: 9925:PI4K2A
uniprot id: A0A452F9T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

9925:IL20RB
gene id: 9925:IL20RB
uniprot id: A0A452F5U9
names: Subcellular Location Annotation
messages: Membrane

9925:MZT1
gene id: 9925:MZT1
uniprot id: A0A8C2NW96
names: Function
names: Similarity
messages: Belongs to the MOZART1 family.
messages: Required for gamma-tubulin complex recruitment to the centrosome.

9925:BANF2
gene id: 9925:BANF2
uniprot id: A0A452DXY5
names: Subcellular Location Annotation
messages: Nucleus

9925:PHOSPHO2
gene id: 9925:PHOSPHO2
uniprot id: A0A452DP76
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.

9925:LOC102181912
gene id: 9925:LOC102181912
uniprot id: A0A452E1V4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:SLC27A2
gene id: 9925:SLC27A2
uniprot id: A0A452EW45
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9925:SGO1
gene id: 9925:SGO1
uniprot id: A0A452EHY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shugoshin family.
messages: centromere

9925:ADSS
gene id: 9925:ADSS
uniprot id: A0A452F9N2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

9925:IZUMO1
gene id: 9925:IZUMO1
uniprot id: C6ZEA2
names: Similarity
messages: Belongs to the Izumo family.

9925:HSP70.1
gene id: 9925:HSP70.1
uniprot id: C5IZH4
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9925:JAG1
gene id: 9925:JAG1
uniprot id: A0A452FH50
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Putative Notch ligand involved in the mediation of Notch signaling.

9925:CEBPA
gene id: 9925:CEBPA
uniprot id: A0A452E8P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9925:DLG5
gene id: 9925:DLG5
uniprot id: A0A452DL30
uniprot id: A0A452DL34
names: Subcellular Location Annotation
messages: Cytoplasm

9925:LOC102189437
gene id: 9925:LOC102189437
uniprot id: A0A452E8K0
names: Function
messages: The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulfur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa).

9925:MYH11
gene id: 9925:MYH11
uniprot id: A0A452E5B5
uniprot id: A0A452E5G1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9925:SYNJ1
gene id: 9925:SYNJ1
uniprot id: A0A452DRT1
names: Similarity
messages: Belongs to the synaptojanin family.
messages: In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.

9925:TLN2
gene id: 9925:TLN2
uniprot id: A0A452FHY8
names: Subcellular Location Annotation
messages: cytoskeleton

9925:PDCD10
gene id: 9925:PDCD10
uniprot id: A0A452FID4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDCD10 family.
messages: Cell membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9925:LOC102172204
gene id: 9925:LOC102172204
uniprot id: A0A452G962
names: Similarity
messages: Belongs to the multicopper oxidase family.

9925:PTPN1
gene id: 9925:PTPN1
uniprot id: A0A452F5G9
uniprot id: A0A452F5H9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

9925:ACAN
gene id: 9925:ACAN
uniprot id: A0A452FGX0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:SMARCAL1
gene id: 9925:SMARCAL1
uniprot id: A0A452G2E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.
messages: Nucleus

9925:FOXH1
gene id: 9925:FOXH1
uniprot id: A0A452EQR0
names: Subcellular Location Annotation
messages: Nucleus

9925:CR2
gene id: 9925:CR2
uniprot id: A0A452FWJ0
uniprot id: A0A452FWW8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:FABP5
gene id: 9925:FABP5
uniprot id: A0A452FM00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9925:SUPT3H
gene id: 9925:SUPT3H
uniprot id: A0A452EWB3
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC108637125
gene id: 9925:LOC108637125
uniprot id: A0A059U2L1
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9925:DECR2
gene id: 9925:DECR2
uniprot id: A0A452FSY2
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.
messages: Monomer, dimer and oligomer.

9925:NEFM
gene id: 9925:NEFM
uniprot id: A0A452FBM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: axon

9925:LOC102179149
gene id: 9925:LOC102179149
uniprot id: A0A452DZN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9925:CORO2A
gene id: 9925:CORO2A
uniprot id: A0A452EDH6
names: Similarity
messages: Belongs to the WD repeat coronin family.

9925:PKM
gene id: 9925:PKM
uniprot id: A0A452ET82
uniprot id: A0A452EU77
names: Similarity
messages: Belongs to the pyruvate kinase family.

9925:FAM173A
gene id: 9925:FAM173A
uniprot id: A0A452FFK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANT/ATPSC lysine N-methyltransferase family.
messages: Mitochondrion membrane

9925:MS4A8
gene id: 9925:MS4A8
uniprot id: A0A452FQR4
names: Similarity
messages: Belongs to the MS4A family.

9925:FAM150B
gene id: 9925:FAM150B
uniprot id: A0A452FD03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALKAL family.
messages: Secreted

9925:HSPH1
gene id: 9925:HSPH1
uniprot id: A0A452DQL9
uniprot id: A0A452DQM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm

9925:GABRP
gene id: 9925:GABRP
uniprot id: A0A452EG27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:MCL1
gene id: 9925:MCL1
uniprot id: A0A452GAH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Cytoplasm
messages: Membrane
messages: nucleoplasm

9925:TRIM3
gene id: 9925:TRIM3
uniprot id: A0A452FJF1
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9925:GK2
gene id: 9925:GK2
uniprot id: A0A452E4Y9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FGGY kinase family.
messages: Cytoplasm

9925:ZNF274
gene id: 9925:ZNF274
uniprot id: A0A452EX19
names: Subcellular Location Annotation
messages: Nucleus

9925:RPS17
gene id: 9925:RPS17
uniprot id: A0A452FU62
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

9925:LOC108636634
gene id: 9925:LOC108636634
uniprot id: A0A452DNC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:F3
gene id: 9925:F3
uniprot id: A0A452FBU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tissue factor family.
messages: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
messages: Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.
messages: Membrane

9925:ZIM2
gene id: 9925:ZIM2
uniprot id: A0A452F975
names: Subcellular Location Annotation
messages: Nucleus

9925:STARD5
gene id: 9925:STARD5
uniprot id: A0A452DQZ5
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9925:SLC46A1
gene id: 9925:SLC46A1
uniprot id: A0A452FFF6
names: Subcellular Location Annotation
messages: Membrane

9925:UBE2U
gene id: 9925:UBE2U
uniprot id: A0A452F661
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9925:NMNAT2
gene id: 9925:NMNAT2
uniprot id: A0A452FLC2
uniprot id: A0A8C2SM35
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9925:ARF3
gene id: 9925:ARF3
uniprot id: A0A452F8V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9925:CCNK
gene id: 9925:CCNK
uniprot id: A0A452FV49
names: Similarity
messages: Belongs to the cyclin family.

9925:MAP2K4
gene id: 9925:MAP2K4
uniprot id: A0A452G3K6
uniprot id: A0A452G3N3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:CLK3
gene id: 9925:CLK3
uniprot id: A0A452EKS8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:PHAX
gene id: 9925:PHAX
uniprot id: A0A452F8M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PHAX family.
messages: Cytoplasm

9925:ATP6V1E2
gene id: 9925:ATP6V1E2
uniprot id: A0A452DNW9
uniprot id: A0A8C2NXJ1
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9925:NCAPG
gene id: 9925:NCAPG
uniprot id: A0A452ECB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND3 (condensin subunit 3) family.
messages: Chromosome

9925:NDUFB6
gene id: 9925:NDUFB6
uniprot id: A0A452GBL7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB6 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9925:ATP2C2
gene id: 9925:ATP2C2
uniprot id: A0A452ECV1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:GCDH
gene id: 9925:GCDH
uniprot id: A0A452DW19
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9925:IRF3
gene id: 9925:IRF3
uniprot id: A0A452F2K8
names: Subcellular Location Annotation
messages: Nucleus

9925:ELOVL4
gene id: 9925:ELOVL4
uniprot id: A0A452EZK2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL4 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Oligomer.
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9925:GIMD1
gene id: 9925:GIMD1
uniprot id: A0A452FJX2
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9925:MAP34-B
gene id: 9925:MAP34-B
uniprot id: P82017
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

9925:MLH3
gene id: 9925:MLH3
uniprot id: A0A452E1B6
uniprot id: A0A452E1C2
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.

9925:LOC102182058
gene id: 9925:LOC102182058
uniprot id: A0A452DNA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102182048
gene id: 9925:LOC102182048
uniprot id: A0A452G7V8
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9925:QRFP
gene id: 9925:QRFP
uniprot id: A0A452E220
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFamide neuropeptide family.
messages: Secreted

9925:GDA
gene id: 9925:GDA
uniprot id: A0A452EPY6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.

9925:DHRS3
gene id: 9925:DHRS3
uniprot id: A0A452DXP9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:TMEM168
gene id: 9925:TMEM168
uniprot id: A0A452EX29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM168 family.
messages: Membrane
messages: Nucleus membrane

9925:CDIP1
gene id: 9925:CDIP1
uniprot id: A0A452EYK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDIP1/LITAF family.
messages: Lysosome membrane

9925:LOC102189641
gene id: 9925:LOC102189641
uniprot id: A0A452DMH3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ATP2A2
gene id: 9925:ATP2A2
uniprot id: A0A452G1T7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Sarcoplasmic reticulum membrane

9925:LOC108638246
gene id: 9925:LOC108638246
uniprot id: A0A452DQ36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9925:RTBDN
gene id: 9925:RTBDN
uniprot id: A0A452F775
names: Similarity
messages: Belongs to the folate receptor family.

9925:IRF8
gene id: 9925:IRF8
uniprot id: A0A452GB37
names: Subcellular Location Annotation
messages: Nucleus

9925:PSMC3
gene id: 9925:PSMC3
uniprot id: A0A8C2RTT9
names: Similarity
messages: Belongs to the AAA ATPase family.

9925:NHSL1
gene id: 9925:NHSL1
uniprot id: A0A452EVY2
uniprot id: A0A452EVY4
uniprot id: A0A452EVZ4
uniprot id: A0A452EW19
uniprot id: A0A452EW29
names: Similarity
messages: Belongs to the NHS family.

9925:FABP9
gene id: 9925:FABP9
uniprot id: A0A452EIY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9925:CHFR
gene id: 9925:CHFR
uniprot id: A0A8C2RLP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CHFR family.
messages: PML body

9925:CDK5R1
gene id: 9925:CDK5R1
uniprot id: A0A452DQK5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Cell membrane
messages: Heterodimer of a catalytic subunit and a regulatory subunit.
messages: Membrane

9925:SIRT5
gene id: 9925:SIRT5
uniprot id: A0A452EZ82
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sirtuin family. Class III subfamily.
messages: Binds 1 zinc ion per subunit.
messages: In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-102 and Arg-105) that bind to malonylated and succinylated substrates and define the specificity.
messages: Mitochondrion
messages: Monomer. Homodimer. Interacts with CPS1.
messages: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as Uox.
messages: Nucleus
messages: cytosol

9925:MYF5
gene id: 9925:MYF5
uniprot id: G4XMU4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9925:TM9SF4
gene id: 9925:TM9SF4
uniprot id: A0A452EE59
uniprot id: A0A452EEF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9925:STXBP5
gene id: 9925:STXBP5
uniprot id: A0A452E2M2
uniprot id: A0A452E2M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat L(2)GL family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9925:SS18L1
gene id: 9925:SS18L1
uniprot id: A0A452FYM5
names: Similarity
messages: Belongs to the SS18 family.

9925:CD70
gene id: 9925:CD70
uniprot id: A0A452G8J0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9925:HS3ST5
gene id: 9925:HS3ST5
uniprot id: A0A452F9V5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9925:GBE1
gene id: 9925:GBE1
uniprot id: A0A452G133
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

9925:LZTS2
gene id: 9925:LZTS2
uniprot id: A0A452F255
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTS2 family.
messages: Cytoplasm
messages: Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.
messages: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
messages: centrosome

9925:ZNF165
gene id: 9925:ZNF165
uniprot id: A0A452E2X6
names: Subcellular Location Annotation
messages: Nucleus

9925:KRT25
gene id: 9925:KRT25
uniprot id: Q6R650
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intermediate filament family.
messages: Cytoplasm
messages: Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity). Plays a role in the cytoskeleton organization (By similarity).
messages: Heterodimer of a type I and a type II keratin. Heterodimer with type II keratin KRT5 leading to the formation of keratin intermediate filament (KIF) network. Interacts with KRT6A to form filaments.
messages: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

9925:C11H2orf68
gene id: 9925:C11H2orf68
uniprot id: A0A452G8C8
names: Similarity
messages: Belongs to the UPF0561 family.

9925:UTP3
gene id: 9925:UTP3
uniprot id: A0A452DN76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAS10 family.
messages: nucleolus

9925:PHGDH
gene id: 9925:PHGDH
uniprot id: A0A452F571
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

9925:KCNN3
gene id: 9925:KCNN3
uniprot id: A0A452F4J8
names: Subcellular Location Annotation
messages: Membrane

9925:PCMT1
gene id: 9925:PCMT1
uniprot id: A0A452G4A6
names: Similarity
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

9925:NUP85
gene id: 9925:NUP85
uniprot id: A0A452F1M9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup85 family.
messages: Component of the nuclear pore complex (NPC).
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: nuclear pore complex

9925:EVX2
gene id: 9925:EVX2
uniprot id: A0A452G8G6
names: Subcellular Location Annotation
messages: Nucleus

9925:B3GNT2
gene id: 9925:B3GNT2
uniprot id: A0A452E0I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:LOC108636981
gene id: 9925:LOC108636981
uniprot id: A0A452DXM6
names: Similarity
messages: Belongs to the universal ribosomal protein uL15 family.

9925:NRG1
gene id: 9925:NRG1
uniprot id: A0A452DN73
uniprot id: A0A452DN86
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuregulin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Secreted

9925:LOC108633854
gene id: 9925:LOC108633854
uniprot id: A0A452FYP3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:EFNB3
gene id: 9925:EFNB3
uniprot id: A0A452GB79
names: Caution
names: Similarity
messages: Belongs to the ephrin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:ZNF768
gene id: 9925:ZNF768
uniprot id: A0A452FW83
names: Subcellular Location Annotation
messages: Nucleus

9925:NUF2
gene id: 9925:NUF2
uniprot id: A0A452FJJ2
names: Similarity
messages: Belongs to the NUF2 family.

9925:TFCP2L1
gene id: 9925:TFCP2L1
uniprot id: A0A452EMG8
uniprot id: A0A452EMH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9925:LOC102168836
gene id: 9925:LOC102168836
uniprot id: A0A452E1X3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:FAM134C
gene id: 9925:FAM134C
uniprot id: A0A452FI73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RETREG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:GJA4
gene id: 9925:GJA4
uniprot id: A0A452DRQ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9925:CAMK2N1
gene id: 9925:CAMK2N1
uniprot id: A0A452EFL6
names: Similarity
messages: Belongs to the CAMK2N family.

9925:LOC102189173
gene id: 9925:LOC102189173
uniprot id: A0A452DTG8
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9925:CAMK1G
gene id: 9925:CAMK1G
uniprot id: A0A452EN66
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:CAND1
gene id: 9925:CAND1
uniprot id: A0A452E570
names: Similarity
messages: Belongs to the CAND family.

9925:COG7
gene id: 9925:COG7
uniprot id: A0A452FES9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COG7 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:FTH1
gene id: 9925:FTH1
uniprot id: A1E459
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9925:GLCE
gene id: 9925:GLCE
uniprot id: A0A452EMT4
names: Similarity
messages: Belongs to the D-glucuronyl C5-epimerase family.

9925:LOC102169935
gene id: 9925:LOC102169935
uniprot id: A0A452EAS0
names: Similarity
messages: Belongs to the arylamine N-acetyltransferase family.

9925:CRYBB2
gene id: 9925:CRYBB2
uniprot id: A0A452EUU4
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9925:STK4
gene id: 9925:STK4
uniprot id: A0A452DPL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Nucleus

9925:LOC102171661
gene id: 9925:LOC102171661
uniprot id: A0A452FGE5
names: Similarity
messages: Belongs to the serpin family.

9925:TXLNA
gene id: 9925:TXLNA
uniprot id: A0A452G8A3
names: Similarity
messages: Belongs to the taxilin family.

9925:UCHL3
gene id: 9925:UCHL3
uniprot id: A0A452F429
uniprot id: A0A8C2QTW9
names: Similarity
messages: Belongs to the peptidase C12 family.

9925:ARSI
gene id: 9925:ARSI
uniprot id: A0A452DTH8
names: Similarity
messages: Belongs to the sulfatase family.

9925:LOC102177153
gene id: 9925:LOC102177153
uniprot id: A0A452FXC1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9925:SPIB
gene id: 9925:SPIB
uniprot id: A0A452F114
uniprot id: A0A8C2SKB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9925:LOC102188914
gene id: 9925:LOC102188914
uniprot id: A0A452E3X7
names: Similarity
messages: Belongs to the WD repeat coronin family.

9925:LOC102175539
gene id: 9925:LOC102175539
uniprot id: A0A452E9N8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102174442
gene id: 9925:LOC102174442
uniprot id: A0A452DWN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ISY1 family.
messages: Nucleus

9925:TAP1
gene id: 9925:TAP1
uniprot id: A0A452FKY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.
messages: Membrane

9925:FERMT3
gene id: 9925:FERMT3
uniprot id: A0A452FWI5
names: Similarity
messages: Belongs to the kindlin family.

9925:SSBP2
gene id: 9925:SSBP2
uniprot id: A0A452FDH7
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC108637117
gene id: 9925:LOC108637117
uniprot id: A0A452EA36
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PAX7
gene id: 9925:PAX7
uniprot id: A0A452FU61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9925:BRPF1
gene id: 9925:BRPF1
uniprot id: A0A452EGQ7
names: Subcellular Location Annotation
messages: Nucleus

9925:PRKAR2A
gene id: 9925:PRKAR2A
uniprot id: A0A452FSH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9925:PAPPA
gene id: 9925:PAPPA
uniprot id: A0A452EXV0
names: Caution
names: Similarity
messages: Belongs to the peptidase M43B family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:SERPINH1
gene id: 9925:SERPINH1
uniprot id: A0A452DNR6
names: Function
names: Similarity
messages: Belongs to the serpin family.
messages: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen.

9925:S100A3
gene id: 9925:S100A3
uniprot id: A0A452F8G7
names: Similarity
messages: Belongs to the S-100 family.

9925:LOC102183874
gene id: 9925:LOC102183874
uniprot id: A0A452EMP1
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9925:DDX43
gene id: 9925:DDX43
uniprot id: A0A452EZM9
names: Similarity
messages: Belongs to the DEAD box helicase family.

9925:NCEH1
gene id: 9925:NCEH1
uniprot id: A0A452FX01
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9925:CPB2
gene id: 9925:CPB2
uniprot id: A0A452EX71
names: Similarity
messages: Belongs to the peptidase M14 family.

9925:NKX1-2
gene id: 9925:NKX1-2
uniprot id: A0A452DZG2
names: Subcellular Location Annotation
messages: Nucleus

9925:UGDH
gene id: 9925:UGDH
uniprot id: A0A452G134
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
messages: Homohexamer.
messages: Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.

9925:GATM
gene id: 9925:GATM
uniprot id: A0A452EZU8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the amidinotransferase family.
messages: Homodimer.
messages: Mitochondrion inner membrane
messages: Transamidinase that catalyzes the transfer of the amidino group of L-arginine onto the amino moiety of acceptor metabolites such as glycine, beta-alanine, gamma-aminobutyric acid (GABA) and taurine yielding the corresponding guanidine derivatives. Catalyzes the rate-limiting step of creatine biosynthesis, namely the transfer of the amidino group from L-arginine to glycine to generate guanidinoacetate, which is then methylated by GAMT to form creatine. Provides creatine as a source for ATP generation in tissues with high energy demands, in particular skeletal muscle, heart and brain.

9925:LOC102174136
gene id: 9925:LOC102174136
uniprot id: A0A452DSG2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102179132
gene id: 9925:LOC102179132
uniprot id: A0A452G3W7
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:RPAP1
gene id: 9925:RPAP1
uniprot id: A0A452FV67
names: Similarity
messages: Belongs to the RPAP1 family.

9925:PTPRN
gene id: 9925:PTPRN
uniprot id: A0A452EK11
uniprot id: A0A8C2NUR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.
messages: Membrane
messages: secretory vesicle membrane

9925:GNL2
gene id: 9925:GNL2
uniprot id: A0A452ERV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.
messages: GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.
messages: nucleolus

9925:DDC
gene id: 9925:DDC
uniprot id: A0A452EHQ2
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9925:LOC102187204
gene id: 9925:LOC102187204
uniprot id: A0A452EBG5
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9925:FAR2
gene id: 9925:FAR2
uniprot id: A0A452FSI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

9925:NKIRAS2
gene id: 9925:NKIRAS2
uniprot id: A0A452GB54
names: Similarity
messages: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily.

9925:ATPIF1
gene id: 9925:ATPIF1
uniprot id: A0A452DUN3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase inhibitor family.
messages: Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase.
messages: Forms an alpha-helical dimer with monomers associated via an antiparallel alpha-helical coiled coil, leaving each N-terminal inhibitory region accessible for interaction with an F1 catalytic domain. The inhibitory N-terminal region binds the alpha(ADP-bound)-beta(ADP-bound) (ATP5F1A-ATP5F1B) interface of F1-ATPase, and also contact the central gamma subunit (ATP5F1C). This dimeric state is favored by pH values below 7.0, and at higher values the dimers associate to form inactive homotetramer, where the inhibitory region is occluded, masking its inhibitory activity.
messages: Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.
messages: Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing fech to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.
messages: Mitochondrion

9925:EIF2B1
gene id: 9925:EIF2B1
uniprot id: A0A452EQN6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2B alpha/beta/delta subunits family.
messages: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.
messages: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

9925:HMOX2
gene id: 9925:HMOX2
uniprot id: A0A452G6X5
names: Similarity
messages: Belongs to the heme oxygenase family.

9925:RELT
gene id: 9925:RELT
uniprot id: A0A8C2NVZ8
names: Similarity
messages: Belongs to the RELT family.

9925:WASF2
gene id: 9925:WASF2
uniprot id: A0A452FUG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9925:TPPP
gene id: 9925:TPPP
uniprot id: A0A452EEM2
names: Similarity
messages: Belongs to the TPPP family.

9925:HMGA1
gene id: 9925:HMGA1
uniprot id: A0A8C2RBX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

9925:VASN
gene id: 9925:VASN
uniprot id: A0A452DMY8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:SLC25A28
gene id: 9925:SLC25A28
uniprot id: A0A452ECQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:LOC102185809
gene id: 9925:LOC102185809
uniprot id: A0A452E3W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:RPS27
gene id: 9925:RPS27
uniprot id: A0A452E3R9
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9925:SRD5A2
gene id: 9925:SRD5A2
uniprot id: A0A452G3Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Membrane
messages: Microsome membrane

9925:CFL2
gene id: 9925:CFL2
uniprot id: A0A452ERY2
names: Similarity
messages: Belongs to the actin-binding proteins ADF family.

9925:ST7
gene id: 9925:ST7
uniprot id: A0A452FCI7
uniprot id: A0A452FCU4
uniprot id: A0A452FCV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ST7 family.
messages: Membrane

9925:LOC102173111
gene id: 9925:LOC102173111
uniprot id: A0A452FFE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
messages: Membrane
messages: Microsome membrane

9925:JAK1
gene id: 9925:JAK1
uniprot id: A0A452EDI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
messages: Endomembrane system

9925:LOC102189594
gene id: 9925:LOC102189594
uniprot id: A0A452FZL0
uniprot id: A0A452FZP1
names: Subcellular Location Annotation
messages: Nucleus

9925:RABGGTB
gene id: 9925:RABGGTB
uniprot id: A0A452EFU3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.

9925:FBXO32
gene id: 9925:FBXO32
uniprot id: A0A452ER17
names: Subcellular Location Annotation
messages: Nucleus

9925:DYNLRB1
gene id: 9925:DYNLRB1
uniprot id: A0A8C2RAJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.
messages: Belongs to the GAMAD family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.
messages: cytoskeleton

9925:MAP3K12
gene id: 9925:MAP3K12
uniprot id: A0A452DY63
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: May be an activator of the JNK/SAPK pathway.

9925:FGF21
gene id: 9925:FGF21
uniprot id: A0A0U2UQ40
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9925:ADAMTS10
gene id: 9925:ADAMTS10
uniprot id: A0A452G1A3
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:PLOD1
gene id: 9925:PLOD1
uniprot id: A0A8C2XYH0
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9925:RPS6KB2
gene id: 9925:RPS6KB2
uniprot id: A0A452E085
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily.
messages: Cytoplasm

9925:AGTPBP1
gene id: 9925:AGTPBP1
uniprot id: A0A452ENM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: cytosol

9925:GLIPR1
gene id: 9925:GLIPR1
uniprot id: A0A452FXP4
names: Similarity
messages: Belongs to the CRISP family.

9925:SLC12A8
gene id: 9925:SLC12A8
uniprot id: A0A452FPS5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9925:TM2D3
gene id: 9925:TM2D3
uniprot id: A0A452EWT6
names: Subcellular Location Annotation
messages: Membrane

9925:NGLY1
gene id: 9925:NGLY1
uniprot id: A0A452GAK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transglutaminase-like superfamily. PNGase family.
messages: Cytoplasm
messages: Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.

9925:WNT10A
gene id: 9925:WNT10A
uniprot id: A0A452FQH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9925:SPICE1
gene id: 9925:SPICE1
uniprot id: A0A452EVC4
uniprot id: A0A452EVG8
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CEP120.
messages: centriole
messages: spindle

9925:DDX18
gene id: 9925:DDX18
uniprot id: A0A452F8X7
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9925:SFT2D2
gene id: 9925:SFT2D2
uniprot id: A0A452FCF9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFT2 family.
messages: May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.
messages: Membrane

9925:SDR42E1
gene id: 9925:SDR42E1
uniprot id: A0A452FPN8
names: Similarity
messages: Belongs to the 3-beta-HSD family.

9925:CAPN12
gene id: 9925:CAPN12
uniprot id: A0A452G2M7
uniprot id: A0A8C2RF46
names: Similarity
messages: Belongs to the peptidase C2 family.

9925:PPT1
gene id: 9925:PPT1
uniprot id: A0A452G0W3
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.

9925:PDGFRA
gene id: 9925:PDGFRA
uniprot id: A0A452DR61
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.
messages: Membrane
messages: Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.
messages: Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.

9925:LOC102172356
gene id: 9925:LOC102172356
uniprot id: A0A452DR83
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:SLC41A2
gene id: 9925:SLC41A2
uniprot id: A0A452DRK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9925:LOC102178603
gene id: 9925:LOC102178603
uniprot id: A0A452DSE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:OPRL1
gene id: 9925:OPRL1
uniprot id: A0A452FWW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
messages: Membrane
messages: Vesicle

9925:CALY
gene id: 9925:CALY
uniprot id: A0A452EBB7
names: Similarity
messages: Belongs to the NSG family.

9925:CKS2
gene id: 9925:CKS2
uniprot id: A0A452FMI2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9925:TOMM7
gene id: 9925:TOMM7
uniprot id: A0A452FTT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom7 family.
messages: Membrane
messages: Mitochondrion outer membrane

9925:CLDN4
gene id: 9925:CLDN4
uniprot id: A0A452DQB9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9925:FAM173B
gene id: 9925:FAM173B
uniprot id: A0A452F4H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANT/ATPSC lysine N-methyltransferase family.
messages: Mitochondrion membrane

9925:CCL19
gene id: 9925:CCL19
uniprot id: A0A452F4T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9925:TMEM177
gene id: 9925:TMEM177
uniprot id: A0A452EH17
names: Function
names: Similarity
messages: Belongs to the TMEM177 family.
messages: Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.

9925:ERC1
gene id: 9925:ERC1
uniprot id: A0A452DQI8
uniprot id: A0A452DQK8
names: Subcellular Location Annotation
messages: Cytoplasm

9925:REEP4
gene id: 9925:REEP4
uniprot id: A0A452G287
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:AIDA
gene id: 9925:AIDA
uniprot id: A0A452DU64
names: Similarity
messages: Belongs to the AIDA family.

9925:PLOD3
gene id: 9925:PLOD3
uniprot id: A0A452EQP3
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane

9925:LOC102180231
gene id: 9925:LOC102180231
uniprot id: A0A8C2NNM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9925:RNF121
gene id: 9925:RNF121
uniprot id: A0A452DUN5
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102178379
gene id: 9925:LOC102178379
uniprot id: A0A452E471
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane

9925:LOC102181948
gene id: 9925:LOC102181948
uniprot id: A0A452DPJ0
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion membrane

9925:OGFR
gene id: 9925:OGFR
uniprot id: A0A452FEU3
names: Similarity
messages: Belongs to the opioid growth factor receptor family.

9925:BCL2L11
gene id: 9925:BCL2L11
uniprot id: A0A452FCR6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Bcl-2 family.
messages: Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1.
messages: Induces apoptosis and anoikis.

9925:CBLB
gene id: 9925:CBLB
uniprot id: A0A452FXQ2
uniprot id: A0A452FY09
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9925:GRHPR
gene id: 9925:GRHPR
uniprot id: A0A452FAD3
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

9925:EML2
gene id: 9925:EML2
uniprot id: A0A452EHH3
uniprot id: A0A452EHR1
names: Similarity
messages: Belongs to the WD repeat EMAP family.

9925:LRP10
gene id: 9925:LRP10
uniprot id: A0A452DQ08
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:MCOLN2
gene id: 9925:MCOLN2
uniprot id: A0A452DXY4
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9925:LOC102188370
gene id: 9925:LOC102188370
uniprot id: A0A452F2I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Golgi pH regulator (TC 1.A.38) family.
messages: Membrane

9925:SUPV3L1
gene id: 9925:SUPV3L1
uniprot id: A0A452DKW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family.
messages: mitochondrion nucleoid

9925:ABI2
gene id: 9925:ABI2
uniprot id: A0A452DNK9
uniprot id: A0A452DNL4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9925:FOXA3
gene id: 9925:FOXA3
uniprot id: A0A452E753
names: Subcellular Location Annotation
messages: Nucleus

9925:C6
gene id: 9925:C6
uniprot id: A0A452FI89
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit C9.
messages: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:DFNB59
gene id: 9925:DFNB59
uniprot id: A0A452EF15
names: Similarity
messages: Belongs to the gasdermin family.

9925:CEBPD
gene id: 9925:CEBPD
uniprot id: A0A452E3Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9925:NR3C1
gene id: 9925:NR3C1
uniprot id: A0A452EXA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Mitochondrion
messages: Nucleus
messages: centrosome
messages: spindle

9925:FFAR3
gene id: 9925:FFAR3
uniprot id: A0A452G8A5
uniprot id: F2VSG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:SLC25A48
gene id: 9925:SLC25A48
uniprot id: A0A452ED82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:VEPH1
gene id: 9925:VEPH1
uniprot id: A0A452GAJ1
names: Similarity
messages: Belongs to the MELT/VEPH family.

9925:ARSJ
gene id: 9925:ARSJ
uniprot id: A0A452E683
names: Similarity
messages: Belongs to the sulfatase family.

9925:SEPT12
gene id: 9925:SEPT12
uniprot id: A0A452EFX8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cytoplasm
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9925:S100A10
gene id: 9925:S100A10
uniprot id: A0A452F2J4
names: Function
messages: Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.

9925:TRIM71
gene id: 9925:TRIM71
uniprot id: A0A452F501
names: Similarity
messages: Belongs to the TRIM/RBCC family.

9925:LOC106503502
gene id: 9925:LOC106503502
uniprot id: A0A452DWU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:DIP2C
gene id: 9925:DIP2C
uniprot id: A0A452FYJ3
uniprot id: A0A452FYR7
names: Similarity
messages: Belongs to the DIP2 family.

9925:LOC102183422
gene id: 9925:LOC102183422
uniprot id: A0A452ECF6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PPFIBP1
gene id: 9925:PPFIBP1
uniprot id: A0A452G647
uniprot id: A0A452G678
uniprot id: A0A452G692
uniprot id: A0A452G698
names: Similarity
messages: Belongs to the liprin family. Liprin-beta subfamily.

9925:LOC102182748
gene id: 9925:LOC102182748
uniprot id: A0A452FXI7
names: Subcellular Location Annotation
messages: Membrane

9925:POLB
gene id: 9925:POLB
uniprot id: A0A452DP61
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Cytoplasm
messages: DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
messages: Nucleus

9925:TUBG1
gene id: 9925:TUBG1
uniprot id: A0A452FUA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
messages: centrosome

9925:ABCA7
gene id: 9925:ABCA7
uniprot id: A0A452FSL8
names: Subcellular Location Annotation
messages: Membrane

9925:ARG2
gene id: 9925:ARG2
uniprot id: A0A452EZD8
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9925:CCR5
gene id: 9925:CCR5
uniprot id: F5B6L8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:ISM1
gene id: 9925:ISM1
uniprot id: A0A452E9N3
uniprot id: A0A452E9V9
names: Similarity
messages: Belongs to the isthmin family.

9925:BMPR2
gene id: 9925:BMPR2
uniprot id: A0A452FD53
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

9925:LOC102178311
gene id: 9925:LOC102178311
uniprot id: A0A452E9A7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Monomer.

9925:AMBP
gene id: 9925:AMBP
uniprot id: A0A8C2QU99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Cell membrane
messages: Endoplasmic reticulum
messages: In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
messages: Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Monomer. Also occurs as a complex with tryptase in mast cells.
messages: Nucleus membrane
messages: cytosol
messages: extracellular matrix

9925:WDR46
gene id: 9925:WDR46
uniprot id: A0A452F223
names: Subcellular Location Annotation
messages: nucleolus

9925:SH3BP4
gene id: 9925:SH3BP4
uniprot id: A0A452EJ91
names: Subcellular Location Annotation
messages: Nucleus
messages: Vesicle
messages: clathrin-coated pit
messages: clathrin-coated vesicle

9925:MTERF1
gene id: 9925:MTERF1
uniprot id: A0A452EFP5
names: Similarity
messages: Belongs to the mTERF family.

9925:SF3A1
gene id: 9925:SF3A1
uniprot id: A0A452F5V2
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102185624
gene id: 9925:LOC102185624
uniprot id: A0A452DWJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SLC44A2
gene id: 9925:SLC44A2
uniprot id: A0A452DSN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTL (choline transporter-like) family.
messages: Cell membrane
messages: Choline transporter.
messages: Membrane

9925:STEAP1
gene id: 9925:STEAP1
uniprot id: A0A452DRR2
names: Subcellular Location Annotation
messages: Membrane

9925:TINAGL1
gene id: 9925:TINAGL1
uniprot id: A0A452FGH0
names: Similarity
messages: Belongs to the peptidase C1 family.

9925:LOC108633303
gene id: 9925:LOC108633303
uniprot id: A0A452FGI7
names: Similarity
messages: Belongs to the CD36 family.

9925:ICAM4
gene id: 9925:ICAM4
uniprot id: A0A452DTI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9925:CD36
gene id: 9925:CD36
uniprot id: A0A452G1U2
uniprot id: F8U3U7
names: Similarity
messages: Belongs to the CD36 family.

9925:AFM
gene id: 9925:AFM
uniprot id: A0A452FDP5
names: Subcellular Location Annotation
messages: Secreted

9925:POMT2
gene id: 9925:POMT2
uniprot id: A0A452FJW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 39 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.

9925:RHOT1
gene id: 9925:RHOT1
uniprot id: A0A452ERV0
uniprot id: A0A452ESX3
uniprot id: A0A452ET91
uniprot id: A0A452ETC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial Rho GTPase family.
messages: Membrane
messages: Mitochondrial GTPase involved in mitochondrial trafficking.
messages: Mitochondrion outer membrane

9925:PAM
gene id: 9925:PAM
uniprot id: A0A452FMY4
uniprot id: A0A452FMZ0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Binds 2 Cu(2+) ions per subunit.
messages: Binds one Zn(2+) ion per subunit.
messages: In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.
messages: In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.
messages: Membrane
messages: secretory vesicle membrane

9925:RBM8A
gene id: 9925:RBM8A
uniprot id: A0A452EAG0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RBM8A family.
messages: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.
messages: Cytoplasm
messages: Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.
messages: Nucleus
messages: Nucleus speckle

9925:C1H3orf58
gene id: 9925:C1H3orf58
uniprot id: A0A452F6X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIPK family.
messages: Secreted

9925:PITPNM2
gene id: 9925:PITPNM2
uniprot id: A0A452DZH8
names: Similarity
messages: Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily.

9925:CSTF1
gene id: 9925:CSTF1
uniprot id: A0A452FZY9
uniprot id: A0A8C2P0H6
names: Subcellular Location Annotation
messages: Nucleus

9925:UBR2
gene id: 9925:UBR2
uniprot id: A0A452E464
uniprot id: A0A452E497
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

9925:CAMK2B
gene id: 9925:CAMK2B
uniprot id: A0A452FS38
uniprot id: A0A452FS53
uniprot id: A0A452FS64
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9925:GAL
gene id: 9925:GAL
uniprot id: A0A452G0F0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galanin family.
messages: Secreted

9925:COG2
gene id: 9925:COG2
uniprot id: A0A452DTR1
names: Similarity
messages: Belongs to the COG2 family.

9925:TASP1
gene id: 9925:TASP1
uniprot id: A0A452FWZ3
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9925:LOC108634231
gene id: 9925:LOC108634231
uniprot id: A0A452DW70
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:LOC102183623
gene id: 9925:LOC102183623
uniprot id: A0A452E2V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF9 family.
messages: Nucleus

9925:MGRN1
gene id: 9925:MGRN1
uniprot id: A0A452DYQ1
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin ligase.

9925:LOC102174004
gene id: 9925:LOC102174004
uniprot id: A0A452DRC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC108633803
gene id: 9925:LOC108633803
uniprot id: A0A452EAS2
names: Similarity
messages: Belongs to the serpin family.

9925:SLC16A4
gene id: 9925:SLC16A4
uniprot id: A0A452G185
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102184589
gene id: 9925:LOC102184589
uniprot id: A0A452ESF0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Cell membrane
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

9925:PEX3
gene id: 9925:PEX3
uniprot id: A0A452G751
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PEX19.
messages: Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.
messages: Peroxisome membrane

9925:NAAA
gene id: 9925:NAAA
uniprot id: A0A452ETD9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acid ceramidase family.
messages: Heterodimer.
messages: Lysosome

9925:TRIM36
gene id: 9925:TRIM36
uniprot id: A0A452EZ09
uniprot id: A0A452EZ20
uniprot id: A0A452EZI7
names: Subcellular Location Annotation
messages: cytoskeleton

9925:DBNDD1
gene id: 9925:DBNDD1
uniprot id: A0A8C2RBE6
uniprot id: A0A8C2RBL2
names: Similarity
messages: Belongs to the dysbindin family.

9925:COPS4
gene id: 9925:COPS4
uniprot id: A0A452EN27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSN4 family.
messages: Nucleus
messages: Vesicle
messages: synaptic vesicle

9925:LOC102175783
gene id: 9925:LOC102175783
uniprot id: A0A452EV45
uniprot id: A0A8C2Y0A9
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9925:GJC2
gene id: 9925:GJC2
uniprot id: A0A452EAK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9925:TFAP2B
gene id: 9925:TFAP2B
uniprot id: A0A452DUX6
uniprot id: A0A452DV38
uniprot id: A0A452DV58
names: Similarity
messages: Belongs to the AP-2 family.

9925:LOC102181426
gene id: 9925:LOC102181426
uniprot id: A0A452G9P5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: myofibril

9925:SLC16A1
gene id: 9925:SLC16A1
uniprot id: A0A452EWC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9925:GPHN
gene id: 9925:GPHN
uniprot id: A0A452FVR5
uniprot id: A0A452FWE2
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
messages: In the C-terminal section; belongs to the MoeA family.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

9925:BAC7.5
gene id: 9925:BAC7.5
uniprot id: Q9XSQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

9925:EVX1
gene id: 9925:EVX1
uniprot id: A0A452EPL2
names: Subcellular Location Annotation
messages: Nucleus

9925:CRBN
gene id: 9925:CRBN
uniprot id: A0A452FQK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRBN family.
messages: Nucleus

9925:LOC102174478
gene id: 9925:LOC102174478
uniprot id: A0A452FW53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9925:PHACTR3
gene id: 9925:PHACTR3
uniprot id: A0A452FGK0
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9925:TPT1
gene id: 9925:TPT1
uniprot id: A0A452E9B2
names: Similarity
messages: Belongs to the TCTP family.

9925:TSPAN18
gene id: 9925:TSPAN18
uniprot id: A0A452FZ43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9925:P2RX4
gene id: 9925:P2RX4
uniprot id: A0A452FR74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9925:LOC102183988
gene id: 9925:LOC102183988
uniprot id: A0A452DQT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ISOC2
gene id: 9925:ISOC2
uniprot id: A0A452FZP2
names: Similarity
messages: Belongs to the isochorismatase family.

9925:CTF1
gene id: 9925:CTF1
uniprot id: A0A452ENB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9925:GPRIN2
gene id: 9925:GPRIN2
uniprot id: A0A452F5Z6
names: Function
messages: May be involved in neurite outgrowth.

9925:IVD
gene id: 9925:IVD
uniprot id: A0A8C2SI76
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9925:CPT2
gene id: 9925:CPT2
uniprot id: A0A452EJ15
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9925:C19H17orf62
gene id: 9925:C19H17orf62
uniprot id: A0A452DRJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CYBC1 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:CCSER1
gene id: 9925:CCSER1
uniprot id: A0A452FAB8
names: Similarity
messages: Belongs to the CCSER family.

9925:LANCL1
gene id: 9925:LANCL1
uniprot id: A0A452ERJ6
names: Similarity
messages: Belongs to the LanC-like protein family.

9925:DUSP3
gene id: 9925:DUSP3
uniprot id: A0A452FUN1
names: Function
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate.

9925:LAMTOR2
gene id: 9925:LAMTOR2
uniprot id: A0A452G7R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GAMAD family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9925:CNTN2
gene id: 9925:CNTN2
uniprot id: A0A452F1L2
names: Similarity
messages: Belongs to the immunoglobulin superfamily. Contactin family.

9925:BTAF1
gene id: 9925:BTAF1
uniprot id: A0A452DUV7
names: Subcellular Location Annotation
messages: Nucleus

9925:SETDB1
gene id: 9925:SETDB1
uniprot id: A0A452E4W2
uniprot id: A0A8C2QQZ7
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9925:CHL1
gene id: 9925:CHL1
uniprot id: A0A452EQE8
uniprot id: A0A452EQJ6
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

9925:SPPL3
gene id: 9925:SPPL3
uniprot id: A0A452G063
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9925:ZDHHC17
gene id: 9925:ZDHHC17
uniprot id: A0A452E0H8
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9925:VCAN
gene id: 9925:VCAN
uniprot id: A0A452G5Y3
uniprot id: A0A452G645
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:ACTR3
gene id: 9925:ACTR3
uniprot id: A0A8C2N4M3
names: Similarity
messages: Belongs to the actin family.

9925:GTPBP8
gene id: 9925:GTPBP8
uniprot id: A0A452G0G5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.

9925:GATAD1
gene id: 9925:GATAD1
uniprot id: A0A452DSY5
names: Subcellular Location Annotation
messages: Nucleus

9925:NXPH2
gene id: 9925:NXPH2
uniprot id: A0A452EJX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9925:RIOK1
gene id: 9925:RIOK1
uniprot id: A0A452DMK3
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9925:PYCR2
gene id: 9925:PYCR2
uniprot id: A0A452FLM2
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9925:RPS18
gene id: 9925:RPS18
uniprot id: A5JST6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Component of the small ribosomal subunit.
messages: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
messages: Cytoplasm

9925:PMEPA1
gene id: 9925:PMEPA1
uniprot id: A0A452FAJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMEPA1 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane

9925:ACADVL
gene id: 9925:ACADVL
uniprot id: A0A452G2D9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9925:TAX1BP3
gene id: 9925:TAX1BP3
uniprot id: A0A452ED96
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Cytoplasm
messages: May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.
messages: Nucleus

9925:MED22
gene id: 9925:MED22
uniprot id: A0A452G4J9
names: Function
names: Subcellular Location Annotation
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Nucleus

9925:MRPS10
gene id: 9925:MRPS10
uniprot id: A0A452FQR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Mitochondrion

9925:IFI30
gene id: 9925:IFI30
uniprot id: A0A452DRL4
names: Similarity
names: Subunit
messages: Belongs to the GILT family.
messages: Dimer; disulfide-linked.

9925:KCNE3
gene id: 9925:KCNE3
uniprot id: A0A452DQN0
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9925:LOC102173264
gene id: 9925:LOC102173264
uniprot id: A0A8C2RTV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9925:RGS7BP
gene id: 9925:RGS7BP
uniprot id: A0A452DVC1
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

9925:FGFR1OP
gene id: 9925:FGFR1OP
uniprot id: A0A452FUY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP43 family.
messages: centriole
messages: cilium basal body

9925:SEC63
gene id: 9925:SEC63
uniprot id: A0A452FIA8
names: Subcellular Location Annotation
messages: Membrane

9925:RPL3L
gene id: 9925:RPL3L
uniprot id: A0A452FDF0
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9925:FGD2
gene id: 9925:FGD2
uniprot id: A0A452GAV1
names: Subcellular Location Annotation
messages: cytoskeleton

9925:CD151
gene id: 9925:CD151
uniprot id: A0A452DY90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9925:LOC102182822
gene id: 9925:LOC102182822
uniprot id: A0A452EAB5
names: Caution
names: Similarity
messages: Belongs to the seminal plasma protein family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:SLC35B4
gene id: 9925:SLC35B4
uniprot id: A0A452EYT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9925:USP45
gene id: 9925:USP45
uniprot id: A0A452EJ08
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9925:TTC39C
gene id: 9925:TTC39C
uniprot id: A0A452DZH3
names: Similarity
messages: Belongs to the TTC39 family.

9925:TNFRSF11B
gene id: 9925:TNFRSF11B
uniprot id: A0A452FZ89
names: Caution
names: Function
names: Subunit
messages: Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:HMGB2
gene id: 9925:HMGB2
uniprot id: A0A452E6V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGB family.
messages: Chromosome

9925:FGF5
gene id: 9925:FGF5
uniprot id: A0A023IMJ9
uniprot id: A0A023IMK1
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9925:LOC102186088
gene id: 9925:LOC102186088
uniprot id: A0A452E0K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:RNF157
gene id: 9925:RNF157
uniprot id: A0A452G8J4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: E3 ubiquitin ligase.

9925:DGAT2
gene id: 9925:DGAT2
uniprot id: A0A452E3L6
uniprot id: M9MR46
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:MYO1B
gene id: 9925:MYO1B
uniprot id: A0A452EGU0
uniprot id: A0A452EH70
uniprot id: A0A452EHI0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9925:LOC102177547
gene id: 9925:LOC102177547
uniprot id: A0A452E1S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PCYT2
gene id: 9925:PCYT2
uniprot id: A0A452DU86
names: Similarity
messages: Belongs to the cytidylyltransferase family.

9925:GAL3ST4
gene id: 9925:GAL3ST4
uniprot id: A0A452G605
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9925:SCAP
gene id: 9925:SCAP
uniprot id: A0A452DVU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SCAP family.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane

9925:UBE2B
gene id: 9925:UBE2B
uniprot id: A0A452F1F4
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9925:POLR3GL
gene id: 9925:POLR3GL
uniprot id: A0A452DXR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Component of the RNA polymerase III (Pol III) complex.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.
messages: Nucleus

9925:WNT2
gene id: 9925:WNT2
uniprot id: A0A452E6K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9925:CLUAP1
gene id: 9925:CLUAP1
uniprot id: A0A452FMQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLUAP1 family.
messages: cilium

9925:YES1
gene id: 9925:YES1
uniprot id: A0A452DK39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9925:FAM114A2
gene id: 9925:FAM114A2
uniprot id: A0A452DP21
names: Similarity
messages: Belongs to the FAM114 family.

9925:LOC102172606
gene id: 9925:LOC102172606
uniprot id: A0A452G3F5
names: Similarity
messages: Belongs to the apolipoprotein L family.

9925:PLK3
gene id: 9925:PLK3
uniprot id: A0A452DML5
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9925:SLC6A2
gene id: 9925:SLC6A2
uniprot id: A0A452FUM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9925:ZKSCAN5
gene id: 9925:ZKSCAN5
uniprot id: A0A452FX78
names: Subcellular Location Annotation
messages: Nucleus

9925:MOCS3
gene id: 9925:MOCS3
uniprot id: A0A8C2NR00
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.
messages: Interacts with NFS1.
messages: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.

9925:SERPINA14
gene id: 9925:SERPINA14
uniprot id: Q5HZ62
names: Similarity
messages: Belongs to the serpin family.

9925:PTS
gene id: 9925:PTS
uniprot id: A0A452G3C5
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the PTPS family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.

9925:TMBIM6
gene id: 9925:TMBIM6
uniprot id: A0A452DMG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9925:LOC102171791
gene id: 9925:LOC102171791
uniprot id: A0A452DRF3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:SNX1
gene id: 9925:SNX1
uniprot id: A0A452FL08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: lamellipodium
messages: trans-Golgi network membrane

9925:PMF1
gene id: 9925:PMF1
uniprot id: A0A452G431
names: Subcellular Location Annotation
messages: Nucleus
messages: kinetochore

9925:PEPD
gene id: 9925:PEPD
uniprot id: A0A452EQV3
names: Similarity
messages: Belongs to the peptidase M24B family.

9925:INHBA
gene id: 9925:INHBA
uniprot id: F8SXW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9925:FOXJ1
gene id: 9925:FOXJ1
uniprot id: A0A452E5H4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FOXJ1 family.
messages: Nucleus

9925:FAM110A
gene id: 9925:FAM110A
uniprot id: A0A452DMV4
names: Similarity
messages: Belongs to the FAM110 family.

9925:C4H7orf25
gene id: 9925:C4H7orf25
uniprot id: A0A452DZ48
names: Similarity
messages: Belongs to the UPF0415 family.

9925:SH3GL1
gene id: 9925:SH3GL1
uniprot id: A0A452GB36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

9925:LRP2
gene id: 9925:LRP2
uniprot id: A0A452F7C6
uniprot id: A0A452F7H5
names: Caution
names: Similarity
messages: Belongs to the LDLR family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:IL26
gene id: 9925:IL26
uniprot id: A0A452G6X4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9925:GCGR
gene id: 9925:GCGR
uniprot id: A0A452E7S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9925:IPPK
gene id: 9925:IPPK
uniprot id: A0A452DXK2
names: Domain
names: Function
names: Similarity
messages: Belongs to the IPK1 type 2 family.
messages: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).
messages: The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

9925:CCS
gene id: 9925:CCS
uniprot id: A0A452ES54
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer; non-disulfide-linked (By similarity). Heterodimer with SOD1. The heterodimer CCS:SOD1 interacts with SLC31A1; this heterotrimer is Cu(1+)-mediated and its maintenance is regulated through SOD1 activation.
messages: In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family.
messages: Nucleus

9925:ANO10
gene id: 9925:ANO10
uniprot id: A0A452EB09
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:ACAP2
gene id: 9925:ACAP2
uniprot id: A0A452FRM0
uniprot id: A0A452FRM8
names: Activity Regulation
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Endosome membrane
messages: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.
messages: GTPase-activating protein for the ADP ribosylation factor family.
messages: PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate protein binding to PIP2 or PIP3 containing membranes.
messages: The BAR domain mediates homodimerization, it can neither bind membrane nor impart curvature, but instead requires the neighboring PH domain to achieve these functions.

9925:RNH1
gene id: 9925:RNH1
uniprot id: A0A452ERC8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.
messages: Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

9925:SPI1
gene id: 9925:SPI1
uniprot id: A0A452FAZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9925:LOC102171271
gene id: 9925:LOC102171271
uniprot id: E1CET8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:OVOL2
gene id: 9925:OVOL2
uniprot id: A0A452F9V3
names: Subcellular Location Annotation
messages: Nucleus

9925:DBP
gene id: 9925:DBP
uniprot id: A0A452FM21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9925:APP
gene id: 9925:APP
uniprot id: A0A452G7Y2
uniprot id: A0A452G817
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Cell membrane
messages: Cell surface
messages: Cytoplasmic vesicle
messages: Early endosome
messages: Endosome
messages: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.
messages: Golgi apparatus
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
messages: Nucleus
messages: Perikaryon
messages: Secreted
messages: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.
messages: Vesicle
messages: clathrin-coated pit
messages: growth cone

9925:LOC102187855
gene id: 9925:LOC102187855
uniprot id: A0A452E324
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102169116
gene id: 9925:LOC102169116
uniprot id: A0A452DPV2
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9925:SMG5
gene id: 9925:SMG5
uniprot id: A0A452DVE1
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in nonsense-mediated mRNA decay.

9925:BSX
gene id: 9925:BSX
uniprot id: A0A452DNT2
names: Subcellular Location Annotation
messages: Nucleus

9925:P2RY2
gene id: 9925:P2RY2
uniprot id: A0A452E0Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:LIMS2
gene id: 9925:LIMS2
uniprot id: A0A452EYS6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.
messages: Cell membrane
messages: Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.
messages: focal adhesion

9925:CSGALNACT1
gene id: 9925:CSGALNACT1
uniprot id: A0A452G045
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9925:ADGRG7
gene id: 9925:ADGRG7
uniprot id: A0A452EVX7
names: Subcellular Location Annotation
messages: Membrane

9925:LOC108636620
gene id: 9925:LOC108636620
uniprot id: A0A452EDS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:CCNJ
gene id: 9925:CCNJ
uniprot id: A0A452F451
names: Similarity
messages: Belongs to the cyclin family.

9925:HNRNPA1
gene id: 9925:HNRNPA1
uniprot id: A0A452G1G3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:MVP
gene id: 9925:MVP
uniprot id: A0A452DVK6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.

9925:EEF1A2
gene id: 9925:EEF1A2
uniprot id: A0A452EWA5
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9925:SRP19
gene id: 9925:SRP19
uniprot id: A0A452F0K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP19 family.
messages: Cytoplasm

9925:FAM198B
gene id: 9925:FAM198B
uniprot id: A0A452G4R9
names: Similarity
messages: Belongs to the GASK family.

9925:ST6GALNAC4
gene id: 9925:ST6GALNAC4
uniprot id: A0A452EEB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9925:CHRNB4
gene id: 9925:CHRNB4
uniprot id: A0A452EA79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:IRF1
gene id: 9925:IRF1
uniprot id: A0A452FBG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Nucleus

9925:MEIS2
gene id: 9925:MEIS2
uniprot id: A0A452EIS6
uniprot id: A0A452EIU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9925:DMRT2
gene id: 9925:DMRT2
uniprot id: A0A452FCE1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9925:TIMM44
gene id: 9925:TIMM44
uniprot id: A0A452FXG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tim44 family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion inner membrane

9925:PDHA2
gene id: 9925:PDHA2
uniprot id: A0A452DWD8
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

9925:NIP7
gene id: 9925:NIP7
uniprot id: A0A452F965
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NIP7 family.
messages: Interacts with pre-ribosome complex.
messages: Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.
messages: nucleolus

9925:PLCB2
gene id: 9925:PLCB2
uniprot id: A0A452DUW1
names: Cofactor
names: Function
messages: Binds 1 Ca(2+) ion per subunit.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9925:TPH2
gene id: 9925:TPH2
uniprot id: A0A452DPA3
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9925:PLPP1
gene id: 9925:PLPP1
uniprot id: A0A452FEW1
uniprot id: A0A452FEX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9925:PIH1D2
gene id: 9925:PIH1D2
uniprot id: A0A452EKE1
names: Similarity
messages: Belongs to the PIH1 family.

9925:FAM102B
gene id: 9925:FAM102B
uniprot id: A0A452F343
names: Similarity
messages: Belongs to the EEIG family.

9925:AACS
gene id: 9925:AACS
uniprot id: A0A452EWJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Converts acetoacetate to acetoacetyl-CoA in the cytosol.
messages: cytosol

9925:SUCLG1
gene id: 9925:SUCLG1
uniprot id: A0A452FEG8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).
messages: Mitochondrion
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.

9925:CLCA1
gene id: 9925:CLCA1
uniprot id: A0A452E9S7
names: Similarity
messages: Belongs to the CLCR family.

9925:C20H5orf22
gene id: 9925:C20H5orf22
uniprot id: A0A452EFH1
names: Similarity
messages: Belongs to the UPF0489 family.

9925:TUBE1
gene id: 9925:TUBE1
uniprot id: A0A452FFB2
names: Similarity
messages: Belongs to the tubulin family.

9925:PROM2
gene id: 9925:PROM2
uniprot id: A0A452F3X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prominin family.
messages: Membrane
messages: microvillus membrane

9925:PON3
gene id: 9925:PON3
uniprot id: A0A452E7W8
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.
messages: Glycosylated.

9925:HOXA2
gene id: 9925:HOXA2
uniprot id: A0A452FXW8
names: Subcellular Location Annotation
messages: Nucleus

9925:IARS2
gene id: 9925:IARS2
uniprot id: A0A452FRE1
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9925:PLIN3
gene id: 9925:PLIN3
uniprot id: A0A452FVG0
uniprot id: G3EHG5
names: Similarity
messages: Belongs to the perilipin family.

9925:SAE1
gene id: 9925:SAE1
uniprot id: A0A452G8A9
names: Similarity
messages: Belongs to the ubiquitin-activating E1 family.

9925:SLC25A32
gene id: 9925:SLC25A32
uniprot id: A0A452EQ86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:SH3YL1
gene id: 9925:SH3YL1
uniprot id: A0A452FRI5
names: Similarity
names: Subunit
messages: Belongs to the SH3YL1 family.
messages: Interacts with SH3D19.

9925:LOC102171690
gene id: 9925:LOC102171690
uniprot id: A0A452DRY6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CXCR6
gene id: 9925:CXCR6
uniprot id: A0A452DM76
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:ACOX1
gene id: 9925:ACOX1
uniprot id: A0A452FJG8
uniprot id: A0A452FJW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acyl-CoA oxidase family.
messages: Peroxisome

9925:POLM
gene id: 9925:POLM
uniprot id: A0A452FQR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-X family.
messages: Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ).
messages: Nucleus

9925:BABAM1
gene id: 9925:BABAM1
uniprot id: A0A452G0F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BABAM1 family.
messages: Nucleus

9925:ASB17
gene id: 9925:ASB17
uniprot id: A0A452DMX7
names: Function
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9925:LTB4R
gene id: 9925:LTB4R
uniprot id: A0A452DW76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9925:TOMM20
gene id: 9925:TOMM20
uniprot id: A0A452DV43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom20 family.
messages: Membrane
messages: Mitochondrion outer membrane

9925:HAPLN2
gene id: 9925:HAPLN2
uniprot id: A0A452G2N9
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:ARFGEF1
gene id: 9925:ARFGEF1
uniprot id: A0A452EAG5
names: Subcellular Location Annotation
messages: Golgi apparatus
messages: perinuclear region

9925:C8H9orf64
gene id: 9925:C8H9orf64
uniprot id: A0A452FIJ0
names: Function
names: Similarity
messages: Belongs to the QNG1 protein family.
messages: Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.

9925:BBOX1
gene id: 9925:BBOX1
uniprot id: A0A452ERN8
names: Function
names: Similarity
messages: Belongs to the gamma-BBH/TMLD family.
messages: Catalyzes the formation of L-carnitine from gamma-butyrobetaine.

9925:PDSS2
gene id: 9925:PDSS2
uniprot id: A0A452EPC2
uniprot id: A0A452EPD3
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9925:NAALADL1
gene id: 9925:NAALADL1
uniprot id: A0A452FV53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

9925:SMARCD2
gene id: 9925:SMARCD2
uniprot id: A0A452E901
names: Similarity
messages: Belongs to the SMARCD family.

9925:TRAK1
gene id: 9925:TRAK1
uniprot id: A0A452E6E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the milton family.
messages: Early endosome
messages: Mitochondrion

9925:KIF11
gene id: 9925:KIF11
uniprot id: A0A452F4R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.
messages: spindle pole

9925:IDH3B
gene id: 9925:IDH3B
uniprot id: A0A452E8M7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9925:TLL2
gene id: 9925:TLL2
uniprot id: A0A452DUH1
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102185739
gene id: 9925:LOC102185739
uniprot id: A0A452FAQ3
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:TMEM173
gene id: 9925:TMEM173
uniprot id: A0A0M4QBF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STING family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Mitochondrion outer membrane
messages: autophagosome membrane
messages: perinuclear region

9925:ACY1
gene id: 9925:ACY1
uniprot id: A0A452EUS4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M20A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Cytoplasm

9925:JAKMIP2
gene id: 9925:JAKMIP2
uniprot id: A0A452EMP8
uniprot id: A0A452ENG7
names: Similarity
messages: Belongs to the JAKMIP family.

9925:LOC102169753
gene id: 9925:LOC102169753
uniprot id: A0A452ECT8
names: Similarity
messages: Belongs to the MHC class I family.

9925:ENTPD5
gene id: 9925:ENTPD5
uniprot id: A0A452G9I2
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9925:HAL
gene id: 9925:HAL
uniprot id: A0A452F7N4
names: Similarity
messages: Belongs to the PAL/histidase family.

9925:SARAF
gene id: 9925:SARAF
uniprot id: A0A452EAI3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SARAF family.
messages: Endoplasmic reticulum membrane
messages: Interacts with STIM1; the interaction is inhibit by th interaction of STIM1 with EFHB.
messages: Membrane
messages: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.

9925:SUCLG2
gene id: 9925:SUCLG2
uniprot id: A0A452FAP5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the succinate/malate CoA ligase beta subunit family. GTP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.
messages: Mitochondrion

9925:PMPCA
gene id: 9925:PMPCA
uniprot id: A0A452EEL9
names: Similarity
messages: Belongs to the peptidase M16 family.

9925:LOC102189356
gene id: 9925:LOC102189356
uniprot id: A0A452EFL3
uniprot id: O19810
names: Similarity
messages: Belongs to the MHC class II family.

9925:BUD31
gene id: 9925:BUD31
uniprot id: A0A452EQF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BUD31 (G10) family.
messages: Nucleus

9925:CREM
gene id: 9925:CREM
uniprot id: E0AEZ7
names: Subcellular Location Annotation
messages: Nucleus

9925:MMP15
gene id: 9925:MMP15
uniprot id: A0A452DNQ5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9925:SENP5
gene id: 9925:SENP5
uniprot id: A0A452ECA1
uniprot id: A0A452ECH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C48 family.
messages: nucleolus

9925:CCL1
gene id: 9925:CCL1
uniprot id: A0A452DND0
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.

9925:GFM2
gene id: 9925:GFM2
uniprot id: A0A452EEF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.
messages: Mitochondrion

9925:PFKFB4
gene id: 9925:PFKFB4
uniprot id: A0A452ETC1
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9925:GTF3C5
gene id: 9925:GTF3C5
uniprot id: A0A452FWN3
uniprot id: A0A452FX53
names: Subcellular Location Annotation
messages: Nucleus

9925:ACYP1
gene id: 9925:ACYP1
uniprot id: A0A452FK47
names: Similarity
messages: Belongs to the acylphosphatase family.

9925:ACADSB
gene id: 9925:ACADSB
uniprot id: A0A452FYW5
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9925:SPTLC2
gene id: 9925:SPTLC2
uniprot id: A0A452FLI5
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

9925:LOC102172279
gene id: 9925:LOC102172279
uniprot id: A0A8C2P3D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm

9925:LOC102188675
gene id: 9925:LOC102188675
uniprot id: A0A452ETY1
names: Similarity
messages: Belongs to the cytochrome c oxidase VIIa family.

9925:LOC102175317
gene id: 9925:LOC102175317
uniprot id: A0A452F723
names: Similarity
messages: Belongs to the globin family.

9925:LOC102190187
gene id: 9925:LOC102190187
uniprot id: A0A452DTE1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SYN2
gene id: 9925:SYN2
uniprot id: A0A452G0M0
names: Similarity
messages: Belongs to the synapsin family.

9925:KCNJ13
gene id: 9925:KCNJ13
uniprot id: A0A452F407
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9925:MTX3
gene id: 9925:MTX3
uniprot id: A0A452FUZ5
uniprot id: A0A452FVF3
uniprot id: A0A8C2PKL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9925:ABT1
gene id: 9925:ABT1
uniprot id: A0A452EET3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF2/ABP1 family.
messages: nucleolus

9925:IRF7
gene id: 9925:IRF7
uniprot id: A0A452E7N2
names: Subcellular Location Annotation
messages: Nucleus

9925:TMEM242
gene id: 9925:TMEM242
uniprot id: A0A452E1X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM242 family.
messages: Membrane

9925:TRAF5
gene id: 9925:TRAF5
uniprot id: A0A452EWZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9925:FPGS
gene id: 9925:FPGS
uniprot id: A0A452DYH9
names: Cofactor
names: Function
names: Similarity
messages: A monovalent cation.
messages: Belongs to the folylpolyglutamate synthase family.
messages: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.

9925:LOC102172545
gene id: 9925:LOC102172545
uniprot id: A0A452DQ37
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:EXOSC2
gene id: 9925:EXOSC2
uniprot id: A0A452FIA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP4 family.
messages: Cytoplasm

9925:LOC102187515
gene id: 9925:LOC102187515
uniprot id: A0A452EFG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane

9925:PDPK1
gene id: 9925:PDPK1
uniprot id: A0A452EQ64
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.

9925:GDE1
gene id: 9925:GDE1
uniprot id: A0A452E2K8
names: Similarity
messages: Belongs to the glycerophosphoryl diester phosphodiesterase family.

9925:TMEM55A
gene id: 9925:TMEM55A
uniprot id: A0A452EPE7
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

9925:LOC102172038
gene id: 9925:LOC102172038
uniprot id: A0A452E9L7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PKP4
gene id: 9925:PKP4
uniprot id: A0A452F4V1
uniprot id: A0A452F522
uniprot id: A0A8C2NJG4
names: Similarity
messages: Belongs to the beta-catenin family.

9925:PRPF18
gene id: 9925:PRPF18
uniprot id: A0A452DLT2
uniprot id: A0A452DLT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP18 family.
messages: Nucleus speckle

9925:GLRA3
gene id: 9925:GLRA3
uniprot id: A0A452E8R0
uniprot id: A0A452E8S5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synapse
messages: Synaptic cell membrane

9925:LOC102187740
gene id: 9925:LOC102187740
uniprot id: A0A452E5Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:NEMP1
gene id: 9925:NEMP1
uniprot id: A0A452ES74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NEMP family.
messages: Nucleus inner membrane

9925:ADAM17
gene id: 9925:ADAM17
uniprot id: A0A452EHS2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:MGST1
gene id: 9925:MGST1
uniprot id: A0A452EP01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9925:NDUFS5
gene id: 9925:NDUFS5
uniprot id: A0A452EWD4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS5 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Membrane
messages: Mitochondrion inner membrane

9925:CLRN1
gene id: 9925:CLRN1
uniprot id: A0A452E3A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9925:NKX2-4
gene id: 9925:NKX2-4
uniprot id: A0A452EYG9
names: Subcellular Location Annotation
messages: Nucleus

9925:FREM1
gene id: 9925:FREM1
uniprot id: A0A452G5J2
names: Similarity
messages: Belongs to the FRAS1 family.

9925:RB1
gene id: 9925:RB1
uniprot id: A0A452DQP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

9925:LOC102175876
gene id: 9925:LOC102175876
uniprot id: P02077
uniprot id: Q1KZF3
names: Function
names: Polymorphism
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: Red blood cells.
messages: There are at least three alleles. The sequence shown is that of allele A.

9925:MAP2K2
gene id: 9925:MAP2K2
uniprot id: A0A452ENE3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:GPR132
gene id: 9925:GPR132
uniprot id: A0A452G436
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:TMCO1
gene id: 9925:TMCO1
uniprot id: A0A452G7G7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMCO1 family.
messages: Calcium-selective channel required to prevent calcium stores from overfilling.
messages: Endoplasmic reticulum membrane
messages: Homodimer and homotetramer. Homodimer under resting conditions; forms homotetramers following and ER calcium overload.
messages: Membrane

9925:XRCC4
gene id: 9925:XRCC4
uniprot id: A0A452ESF1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XRCC4-XLF family. XRCC4 subfamily.
messages: Nucleus

9925:FAM49B
gene id: 9925:FAM49B
uniprot id: A0A452DS77
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9925:DEUP1
gene id: 9925:DEUP1
uniprot id: A0A452F4F4
uniprot id: A0A452F534
uniprot id: A0A452F567
names: Similarity
messages: Belongs to the CEP63 family.

9925:SETD7
gene id: 9925:SETD7
uniprot id: A0A452E0J4
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9925:LYZL4
gene id: 9925:LYZL4
uniprot id: F2X044
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9925:RARB
gene id: 9925:RARB
uniprot id: A0A452E9H5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9925:TCIRG1
gene id: 9925:TCIRG1
uniprot id: A0A452FLX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.
messages: Membrane

9925:SEPSECS
gene id: 9925:SEPSECS
uniprot id: A0A452E592
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SepSecS family.
messages: Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm
messages: Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer.

9925:RHBDD3
gene id: 9925:RHBDD3
uniprot id: A0A452EYQ4
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102184912
gene id: 9925:LOC102184912
uniprot id: A0A452EQF7
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9925:THBS1
gene id: 9925:THBS1
uniprot id: A0A8C2QT22
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:CHST10
gene id: 9925:CHST10
uniprot id: A0A452F9W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:TONSL
gene id: 9925:TONSL
uniprot id: A0A452ETD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tonsoku family.
messages: Chromosome

9925:C11H9orf116
gene id: 9925:C11H9orf116
uniprot id: A0A452ER33
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.
messages: cilium axoneme

9925:KIF7
gene id: 9925:KIF7
uniprot id: A0A452DV85
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9925:FRRS1
gene id: 9925:FRRS1
uniprot id: A0A452G9W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRRS1 family.
messages: Membrane

9925:SPOCK2
gene id: 9925:SPOCK2
uniprot id: A0A452E9H3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:MOCS2
gene id: 9925:MOCS2
uniprot id: A0A452EM96
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MoaE family. MOCS2B subfamily.
messages: Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
messages: Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.
messages: This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.
messages: cytosol

9925:LGMN
gene id: 9925:LGMN
uniprot id: A0A452FXU3
names: Similarity
messages: Belongs to the peptidase C13 family.

9925:PPP1R11
gene id: 9925:PPP1R11
uniprot id: A0A452F797
names: Subunit
messages: Interacts with TLR2 and UBE2D2.

9925:FA2H
gene id: 9925:FA2H
uniprot id: A0A452EAY8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sterol desaturase family. SCS7 subfamily.
messages: Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.
messages: Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:YEATS2
gene id: 9925:YEATS2
uniprot id: A0A452EH41
uniprot id: A0A452EH57
uniprot id: A0A452EHI6
names: Subcellular Location Annotation
messages: Nucleus

9925:SCNN1B
gene id: 9925:SCNN1B
uniprot id: A0A452FJC0
names: Subcellular Location Annotation
messages: Membrane

9925:FBXO34
gene id: 9925:FBXO34
uniprot id: A0A8C2P1J4
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9925:TAF12
gene id: 9925:TAF12
uniprot id: A0A452DNQ3
uniprot id: A0A8C2NC12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF12 family.
messages: Nucleus

9925:EIF5A
gene id: 9925:EIF5A
uniprot id: A0A452G2G2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.
messages: eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.

9925:PGAM2
gene id: 9925:PGAM2
uniprot id: A0A452DR91
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9925:ACVRL1
gene id: 9925:ACVRL1
uniprot id: A0A452GAD6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9925:RNF145
gene id: 9925:RNF145
uniprot id: A0A452FEL0
names: Subcellular Location Annotation
messages: Membrane

9925:DMRTC2
gene id: 9925:DMRTC2
uniprot id: A0A452FCR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9925:BPNT1
gene id: 9925:BPNT1
uniprot id: A0A452E7K8
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9925:LOC108633367
gene id: 9925:LOC108633367
uniprot id: A0A452DNJ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAM41 family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Mitochondrion inner membrane

9925:KCNS3
gene id: 9925:KCNS3
uniprot id: A0A452EEM7
names: Subcellular Location Annotation
messages: Membrane

9925:MYO1E
gene id: 9925:MYO1E
uniprot id: A0A452EFM9
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9925:TCP11L1
gene id: 9925:TCP11L1
uniprot id: A0A452FGU9
names: Similarity
messages: Belongs to the TCP11 family.

9925:SLC10A2
gene id: 9925:SLC10A2
uniprot id: A0A452DMU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9925:PDGFA
gene id: 9925:PDGFA
uniprot id: A0A452EPV8
uniprot id: A0A452EQS6
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9925:IRF2
gene id: 9925:IRF2
uniprot id: A0A452F0Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF family.
messages: Nucleus

9925:GNPDA1
gene id: 9925:GNPDA1
uniprot id: A0A452EPE5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9925:HADHA
gene id: 9925:HADHA
uniprot id: A0A452FPW8
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.

9925:CHMP2A
gene id: 9925:CHMP2A
uniprot id: A0A452E6P7
names: Similarity
messages: Belongs to the SNF7 family.

9925:ADGRG3
gene id: 9925:ADGRG3
uniprot id: A0A452E5P8
names: Subcellular Location Annotation
messages: Membrane

9925:FAM160A2
gene id: 9925:FAM160A2
uniprot id: A0A452FHR0
names: Similarity
messages: Belongs to the FHIP family.

9925:LPL
gene id: 9925:LPL
uniprot id: A0A452G3Y2
uniprot id: A2SY11
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.
messages: Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted
messages: Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
messages: extracellular matrix

9925:SPON2
gene id: 9925:SPON2
uniprot id: A0A452F5J8
names: Subcellular Location Annotation
messages: extracellular matrix

9925:KCNA1
gene id: 9925:KCNA1
uniprot id: A0A452DP60
names: Subcellular Location Annotation
messages: Membrane

9925:CLTA
gene id: 9925:CLTA
uniprot id: A0A452ETA7
uniprot id: A0A452EU53
uniprot id: A0A8C2PBV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9925:DSC1
gene id: 9925:DSC1
uniprot id: A0A452DSZ0
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9925:PNLIPRP2
gene id: 9925:PNLIPRP2
uniprot id: A0A452E9I7
uniprot id: A0A452E9M4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9925:TXK
gene id: 9925:TXK
uniprot id: A0A452EG23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9925:ADAMTS15
gene id: 9925:ADAMTS15
uniprot id: A0A452FK00
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:EYA1
gene id: 9925:EYA1
uniprot id: A0A452FKX1
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9925:CALR
gene id: 9925:CALR
uniprot id: A0A452FTJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

9925:LNPEP
gene id: 9925:LNPEP
uniprot id: A0A452ECW8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Membrane

9925:ELAVL2
gene id: 9925:ELAVL2
uniprot id: A0A452G4V5
uniprot id: A0A8C2NMD8
names: Similarity
messages: Belongs to the RRM elav family.

9925:AUH
gene id: 9925:AUH
uniprot id: A0A452EXY1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9925:TDRD3
gene id: 9925:TDRD3
uniprot id: A0A452FBU3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus
messages: Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. Plays a role in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, acts as an antiviral factor that participates in the assembly of stress granules together with G3BP1.

9925:LOC102182191
gene id: 9925:LOC102182191
uniprot id: A0A452DM30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:EBF2
gene id: 9925:EBF2
uniprot id: A0A452FUU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9925:ZADH2
gene id: 9925:ZADH2
uniprot id: A0A452F8C8
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9925:FLI1
gene id: 9925:FLI1
uniprot id: A0A452ESN9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9925:ATP5E
gene id: 9925:ATP5E
uniprot id: A0A452FTG4
names: Function
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9925:HOXD13
gene id: 9925:HOXD13
uniprot id: A0A452E217
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9925:PGGT1B
gene id: 9925:PGGT1B
uniprot id: A0A452G303
names: Similarity
messages: Belongs to the protein prenyltransferase subunit beta family.

9925:INHBB
gene id: 9925:INHBB
uniprot id: A0A452FXK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9925:TMEM178B
gene id: 9925:TMEM178B
uniprot id: A0A8C2RUI2
names: Similarity
messages: Belongs to the TMEM178 family.

9925:ZER1
gene id: 9925:ZER1
uniprot id: A0A8C2SKC5
names: Similarity
messages: Belongs to the zyg-11 family.

9925:COG6
gene id: 9925:COG6
uniprot id: A0A452DTQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG6 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane
messages: Required for normal Golgi function.

9925:ESF1
gene id: 9925:ESF1
uniprot id: A0A452FHK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ESF1 family.
messages: nucleolus

9925:SFMBT1
gene id: 9925:SFMBT1
uniprot id: A0A452E4E2
names: Subcellular Location Annotation
messages: Nucleus

9925:TEK
gene id: 9925:TEK
uniprot id: A0A452EJM8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:LOC102190621
gene id: 9925:LOC102190621
uniprot id: A0A452ENP1
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:DNAAF2
gene id: 9925:DNAAF2
uniprot id: A0A452EXP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIH1 family. Kintoun subfamily.
messages: Cytoplasm
messages: Interacts with CFAP300. Interacts with DNAI2 and HSPA1A. Interacts with DYX1C1. Interacts with PIH1D3.
messages: Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.

9925:TMEM132A
gene id: 9925:TMEM132A
uniprot id: A0A452FCT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

9925:PSMD3
gene id: 9925:PSMD3
uniprot id: A0A452DQ07
names: Similarity
messages: Belongs to the proteasome subunit S3 family.

9925:NPY2R
gene id: 9925:NPY2R
uniprot id: A0A452E276
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:LOC108636046
gene id: 9925:LOC108636046
uniprot id: A0A452DUW8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:CDC34
gene id: 9925:CDC34
uniprot id: A0A452G517
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9925:MYOZ3
gene id: 9925:MYOZ3
uniprot id: A0A023IYH7
names: Similarity
messages: Belongs to the myozenin family.

9925:COPZ1
gene id: 9925:COPZ1
uniprot id: G8JEB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adaptor complexes small subunit family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.

9925:DYRK1B
gene id: 9925:DYRK1B
uniprot id: A0A452EJ92
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9925:ATXN10
gene id: 9925:ATXN10
uniprot id: A0A452EMJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ataxin-10 family.
messages: Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.
messages: perinuclear region

9925:CALHM3
gene id: 9925:CALHM3
uniprot id: A0A452F9Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9925:SCD
gene id: 9925:SCD
uniprot id: Q9BG81
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9925:RPL30
gene id: 9925:RPL30
uniprot id: A0A452EXP6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL30 family.

9925:HSPA6
gene id: 9925:HSPA6
uniprot id: A0A8C2S128
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9925:LOC102177231
gene id: 9925:LOC102177231
uniprot id: A0A452EP69
names: Similarity
messages: Belongs to the intermediate filament family.

9925:LOC102191519
gene id: 9925:LOC102191519
uniprot id: A0A452F606
uniprot id: A0A452F615
uniprot id: A0A452F619
uniprot id: A0A452F630
uniprot id: A0A452F635
uniprot id: A0A452F640
uniprot id: A0A452F6G5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

9925:UBR1
gene id: 9925:UBR1
uniprot id: A0A452FHV0
names: Function
names: Similarity
messages: Belongs to the UBR1 family.
messages: Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

9925:TAGLN
gene id: 9925:TAGLN
uniprot id: A0A452EMK6
names: Similarity
messages: Belongs to the calponin family.

9925:PRKCQ
gene id: 9925:PRKCQ
uniprot id: A0A452EU28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9925:TMEM65
gene id: 9925:TMEM65
uniprot id: A0A452E2Z8
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102184691
gene id: 9925:LOC102184691
uniprot id: A0A452E5B0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TRMT1L
gene id: 9925:TRMT1L
uniprot id: A0A452EW57
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: May play a role in motor coordination and exploratory behavior.

9925:LIN54
gene id: 9925:LIN54
uniprot id: A0A452FZZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lin-54 family.
messages: Nucleus

9925:LAP3
gene id: 9925:LAP3
uniprot id: A0A452DVV1
names: Similarity
names: Subunit
messages: Belongs to the peptidase M17 family.
messages: Homohexamer.

9925:CMTM2
gene id: 9925:CMTM2
uniprot id: A0A452G158
names: Subcellular Location Annotation
messages: Membrane

9925:RPE65
gene id: 9925:RPE65
uniprot id: A0A452FS16
names: Cofactor
names: Similarity
messages: Belongs to the carotenoid oxygenase family.
messages: Binds 1 Fe(2+) ion per subunit.

9925:MECOM
gene id: 9925:MECOM
uniprot id: A0A8C2NJD0
names: Subcellular Location Annotation
messages: Nucleus

9925:POLR3H
gene id: 9925:POLR3H
uniprot id: A0A452EJ27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9925:FMNL3
gene id: 9925:FMNL3
uniprot id: A0A452ERD3
uniprot id: A0A452ERF2
uniprot id: A0A452ESE6
uniprot id: A0A8C2NC18
names: Similarity
messages: Belongs to the formin homology family.

9925:IZUMO1R
gene id: 9925:IZUMO1R
uniprot id: A0A452GAF9
names: Similarity
messages: Belongs to the folate receptor family.

9925:LOC102185625
gene id: 9925:LOC102185625
uniprot id: A0A452DU84
names: Similarity
messages: Belongs to the EXO5 family.

9925:PPTC7
gene id: 9925:PPTC7
uniprot id: A0A452FCJ3
names: Similarity
messages: Belongs to the PP2C family.

9925:IPO11
gene id: 9925:IPO11
uniprot id: A0A452EFT8
uniprot id: A0A452EFY9
names: Subcellular Location Annotation
messages: Cytoplasm

9925:JPH2
gene id: 9925:JPH2
uniprot id: A0A452G3E6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9925:NEU1
gene id: 9925:NEU1
uniprot id: A0A452E680
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9925:CLK1
gene id: 9925:CLK1
uniprot id: A0A452F4V5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:MAP3K14
gene id: 9925:MAP3K14
uniprot id: A0A452EZ55
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cytoplasm
messages: Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity.

9925:NEU3
gene id: 9925:NEU3
uniprot id: A0A452G1F1
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9925:DTX1
gene id: 9925:DTX1
uniprot id: A0A452F5Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9925:POLR2M
gene id: 9925:POLR2M
uniprot id: A0A452DM08
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRINL1 family.
messages: Nucleus

9925:TMEM184B
gene id: 9925:TMEM184B
uniprot id: A0A452FSF9
uniprot id: A0A452FSG4
names: Subcellular Location Annotation
messages: Membrane

9925:C4BPA
gene id: 9925:C4BPA
uniprot id: A0A452FQ19
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:PDE6H
gene id: 9925:PDE6H
uniprot id: A0A452G6G7
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

9925:TRIP12
gene id: 9925:TRIP12
uniprot id: A0A452EH82
uniprot id: A0A452EH96
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPL family. K-HECT subfamily.
messages: E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins.
messages: nucleoplasm

9925:PDIA4
gene id: 9925:PDIA4
uniprot id: A0A452FD52
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Part of a large chaperone multiprotein complex.

9925:CHST3
gene id: 9925:CHST3
uniprot id: A0A452FDR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9925:GNPDA2
gene id: 9925:GNPDA2
uniprot id: A0A452FQ40
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.
messages: Cytoplasm
messages: Homohexamer.

9925:SLC46A3
gene id: 9925:SLC46A3
uniprot id: A0A452DSG4
names: Subcellular Location Annotation
messages: Membrane

9925:ITPK1
gene id: 9925:ITPK1
uniprot id: A0A452EZG1
names: Similarity
messages: Belongs to the ITPK1 family.

9925:TMEM106A
gene id: 9925:TMEM106A
uniprot id: A0A452DM33
names: Similarity
messages: Belongs to the TMEM106 family.

9925:MCEE
gene id: 9925:MCEE
uniprot id: A0A452FD94
names: Similarity
messages: Belongs to the methylmalonyl-CoA epimerase family.

9925:TMEM136
gene id: 9925:TMEM136
uniprot id: A0A452FEK8
names: Subcellular Location Annotation
messages: Membrane

9925:NCSTN
gene id: 9925:NCSTN
uniprot id: A0A452GAX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicastrin family.
messages: Membrane

9925:RNF146
gene id: 9925:RNF146
uniprot id: A0A452FPC5
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.
messages: The WWE domain mediates non-covalent poly(ADP-ribose)-binding.
messages: Ubiquitinated; autoubiquitinated.
messages: cytosol

9925:LOC102175117
gene id: 9925:LOC102175117
uniprot id: A0A452E685
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:HCFC2
gene id: 9925:HCFC2
uniprot id: A0A452E8F8
uniprot id: A0A452E8J2
names: Subcellular Location Annotation
messages: Nucleus

9925:ARF5
gene id: 9925:ARF5
uniprot id: A0A452F738
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9925:BLOC1S6
gene id: 9925:BLOC1S6
uniprot id: A0A452FJE5
names: Function
names: Similarity
messages: Belongs to the BLOC1S6 family.
messages: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.

9925:MADD
gene id: 9925:MADD
uniprot id: A0A452DQ03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MADD family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9925:MRGPRF
gene id: 9925:MRGPRF
uniprot id: A0A452FY84
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:NCK1
gene id: 9925:NCK1
uniprot id: A0A452ECW4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9925:NRN1
gene id: 9925:NRN1
uniprot id: A0A452FRV8
names: Similarity
messages: Belongs to the neuritin family.

9925:ADAMTS4
gene id: 9925:ADAMTS4
uniprot id: A0A452G9L9
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:IGF1R
gene id: 9925:IGF1R
uniprot id: A0A452FWJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9925:HMGA2
gene id: 9925:HMGA2
uniprot id: Q76M67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGA family.
messages: Nucleus

9925:NPPB
gene id: 9925:NPPB
uniprot id: A0A452ER42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the natriuretic peptide family.
messages: Cardiac hormone that plays a key role in mediating cardio-renal homeostasis (By similarity). May also function as a paracrine antifibrotic factor in the heart (By similarity). Acts by specifically binding and stimulating NPR1 to produce cGMP, which in turn activates effector proteins that drive various biological responses. Involved in regulating the extracellular fluid volume and maintaining the fluid-electrolyte balance through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Binds the clearance receptor NPR3.
messages: Secreted

9925:SLC1A2
gene id: 9925:SLC1A2
uniprot id: A0A452G9L0
uniprot id: A0A452GA48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9925:LOC108633874
gene id: 9925:LOC108633874
uniprot id: P13786
names: Function
names: Similarity
names: Subunit
messages: Belongs to the globin family.
messages: Heterotetramer of two zeta chains and beta-type chains.
messages: The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.

9925:CLDN17
gene id: 9925:CLDN17
uniprot id: A0A452DY43
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9925:ATP6V1G3
gene id: 9925:ATP6V1G3
uniprot id: A0A452E362
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9925:SCAMP3
gene id: 9925:SCAMP3
uniprot id: A0A452DRK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9925:RNPEPL1
gene id: 9925:RNPEPL1
uniprot id: A0A452DVF8
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.

9925:EMC4
gene id: 9925:EMC4
uniprot id: A0A452FDK9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EMC4 family.
messages: Component of the ER membrane protein complex (EMC).
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:MPP5
gene id: 9925:MPP5
uniprot id: A0A452FTV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Endomembrane system
messages: adherens junction
messages: tight junction

9925:CCNL2
gene id: 9925:CCNL2
uniprot id: A0A452F7N7
names: Similarity
messages: Belongs to the cyclin family.

9925:KCNH4
gene id: 9925:KCNH4
uniprot id: A0A452DQZ2
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9925:SKI
gene id: 9925:SKI
uniprot id: A0A452E7Z2
names: Similarity
messages: Belongs to the SKI family.

9925:C11H2orf49
gene id: 9925:C11H2orf49
uniprot id: A0A452E9A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ashwin family.
messages: Nucleus

9925:FIGN
gene id: 9925:FIGN
uniprot id: A0A452F2S0
names: Similarity
messages: Belongs to the AAA ATPase family.

9925:SLC7A7
gene id: 9925:SLC7A7
uniprot id: A0A452FNJ4
names: Subcellular Location Annotation
messages: Membrane

9925:GRINA
gene id: 9925:GRINA
uniprot id: A0A452DNP5
names: Subcellular Location Annotation
messages: Membrane

9925:DPF3
gene id: 9925:DPF3
uniprot id: A0A452FYA8
names: Similarity
messages: Belongs to the requiem/DPF family.

9925:AURKB
gene id: 9925:AURKB
uniprot id: A0A452FQM2
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

9925:SEH1L
gene id: 9925:SEH1L
uniprot id: A0A452DSH5
uniprot id: A0A452DSM8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.
messages: Lysosome membrane
messages: kinetochore

9925:LOC102172658
gene id: 9925:LOC102172658
uniprot id: A0A452DP30
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9925:LOC102173518
gene id: 9925:LOC102173518
uniprot id: A0A452DUW4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:EIF4G1
gene id: 9925:EIF4G1
uniprot id: A0A452E1M0
uniprot id: A0A452E1R5
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4G family.

9925:LAPTM4A
gene id: 9925:LAPTM4A
uniprot id: A0A452FMQ8
names: Similarity
messages: Belongs to the LAPTM4/LAPTM5 transporter family.

9925:TMED9
gene id: 9925:TMED9
uniprot id: A0A452DYG0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:LGI2
gene id: 9925:LGI2
uniprot id: A0A452FMI4
names: Subcellular Location Annotation
messages: Secreted

9925:SLC35E3
gene id: 9925:SLC35E3
uniprot id: A0A452EG41
names: Subcellular Location Annotation
messages: Membrane

9925:MTRF1L
gene id: 9925:MTRF1L
uniprot id: A0A452DV90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9925:BPGM
gene id: 9925:BPGM
uniprot id: A0A452EPH7
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

9925:SEC22C
gene id: 9925:SEC22C
uniprot id: A0A452E0W4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: May be involved in vesicle transport between the ER and the Golgi complex.
messages: Membrane

9925:EIF4ENIF1
gene id: 9925:EIF4ENIF1
uniprot id: A0A452EVX9
uniprot id: A0A452EVY9
names: Subcellular Location Annotation
messages: Cytoplasm

9925:ESCO1
gene id: 9925:ESCO1
uniprot id: A0A452EX35
names: Subcellular Location Annotation
messages: Nucleus

9925:EIF3H
gene id: 9925:EIF3H
uniprot id: A0A452E9C1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit H family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9925:MOCS1
gene id: 9925:MOCS1
uniprot id: A0A452E0P0
uniprot id: A0A452E0S3
names: Similarity
messages: In the C-terminal section; belongs to the MoaC family.
messages: In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.

9925:NUMBL
gene id: 9925:NUMBL
uniprot id: A0A452FKE8
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Plays a role in the process of neurogenesis.

9925:FBLN7
gene id: 9925:FBLN7
uniprot id: A0A452FM07
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:ACSF3
gene id: 9925:ACSF3
uniprot id: A0A452EDD9
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9925:STRN
gene id: 9925:STRN
uniprot id: A0A452G098
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

9925:DIS3L2
gene id: 9925:DIS3L2
uniprot id: A0A452FLN2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.
messages: Belongs to the RNR ribonuclease family. DIS3L2 subfamily.
messages: Cytoplasm
messages: P-body
messages: Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site.

9925:ABCD2
gene id: 9925:ABCD2
uniprot id: A0A452DQS5
names: Subcellular Location Annotation
messages: Membrane

9925:DHRS11
gene id: 9925:DHRS11
uniprot id: A0A452EN76
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:ADPRH
gene id: 9925:ADPRH
uniprot id: A0A452FWL7
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9925:VIM
gene id: 9925:VIM
uniprot id: A0A452FE94
names: Similarity
messages: Belongs to the intermediate filament family.

9925:SLC41A1
gene id: 9925:SLC41A1
uniprot id: A0A452ELH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9925:PDK2
gene id: 9925:PDK2
uniprot id: A0A452FM72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9925:SYNDIG1
gene id: 9925:SYNDIG1
uniprot id: A0A452FDE2
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9925:TAGLN2
gene id: 9925:TAGLN2
uniprot id: A0A452GB99
names: Similarity
messages: Belongs to the calponin family.

9925:HSPA8
gene id: 9925:HSPA8
uniprot id: I6ZQY0
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9925:VLDLR
gene id: 9925:VLDLR
uniprot id: A0A452FJ19
uniprot id: A0A452FJT0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:RNF167
gene id: 9925:RNF167
uniprot id: A0A452ESQ1
names: Subcellular Location Annotation
messages: Membrane

9925:CGA
gene id: 9925:CGA
uniprot id: A0A452F3Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycoprotein hormones subunit alpha family.
messages: Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.
messages: Secreted
messages: Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.

9925:ACTRT3
gene id: 9925:ACTRT3
uniprot id: A0A452EFY7
names: Similarity
messages: Belongs to the actin family.

9925:RYBP
gene id: 9925:RYBP
uniprot id: A0A452G5R2
names: Subcellular Location Annotation
messages: Nucleus

9925:CDK3
gene id: 9925:CDK3
uniprot id: A0A452FB20
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:AMDHD1
gene id: 9925:AMDHD1
uniprot id: A0A452FW07
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. HutI family.

9925:PKD2
gene id: 9925:PKD2
uniprot id: A0A452FDG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Cell membrane
messages: Membrane
messages: cilium membrane

9925:MDFIC
gene id: 9925:MDFIC
uniprot id: A0A452EA12
names: Similarity
messages: Belongs to the MDFI family.

9925:PPARD
gene id: 9925:PPARD
uniprot id: A0A452EIP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9925:TRAM2
gene id: 9925:TRAM2
uniprot id: A0A452EMI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9925:LOC102187311
gene id: 9925:LOC102187311
uniprot id: A0A452FUU3
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:HMGCL
gene id: 9925:HMGCL
uniprot id: A0A452GAC9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HMG-CoA lyase family.
messages: Homodimer; disulfide-linked. Can also form homotetramers.
messages: Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.

9925:LOC108636618
gene id: 9925:LOC108636618
uniprot id: A0A452E0E0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:LOC102177819
gene id: 9925:LOC102177819
uniprot id: A0A452E5Z9
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9925:NPY1R
gene id: 9925:NPY1R
uniprot id: A0A452EBA1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:CACUL1
gene id: 9925:CACUL1
uniprot id: A0A452EDP4
names: Similarity
messages: Belongs to the cullin family.

9925:CDCA7L
gene id: 9925:CDCA7L
uniprot id: A0A452EE54
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:CTPS1
gene id: 9925:CTPS1
uniprot id: A0A452G8M5
names: Function
names: Similarity
messages: Belongs to the CTP synthase family.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.

9925:SLC39A9
gene id: 9925:SLC39A9
uniprot id: A0A452F2E2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Cell membrane
messages: Membrane
messages: Mitochondrion
messages: Nucleus
messages: Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Also functions as membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. Moreover, has dual functions as membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process.
messages: perinuclear region
messages: trans-Golgi network membrane

9925:LOC102190176
gene id: 9925:LOC102190176
uniprot id: A0A452EKK5
names: Similarity
messages: Belongs to the TFIIB family.

9925:LOC102174112
gene id: 9925:LOC102174112
uniprot id: A0A452DSH9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ANXA13
gene id: 9925:ANXA13
uniprot id: A0A452EBX8
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9925:TNS2
gene id: 9925:TNS2
uniprot id: A0A452DSA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9925:EIF1B
gene id: 9925:EIF1B
uniprot id: A0A8C2RZ69
names: Similarity
messages: Belongs to the SUI1 family.

9925:PPP1R15B
gene id: 9925:PPP1R15B
uniprot id: A0A452EEV5
names: Similarity
messages: Belongs to the PPP1R15 family.

9925:FNIP1
gene id: 9925:FNIP1
uniprot id: A0A452FGE6
uniprot id: A0A452FGP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

9925:SST
gene id: 9925:SST
uniprot id: E2DI30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatostatin family.
messages: Secreted

9925:PPM1G
gene id: 9925:PPM1G
uniprot id: A0A452DQH5
names: Similarity
messages: Belongs to the PP2C family.

9925:LOC106502924
gene id: 9925:LOC106502924
uniprot id: A0A452DWA0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ART3
gene id: 9925:ART3
uniprot id: A0A452FJ61
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9925:KBTBD8
gene id: 9925:KBTBD8
uniprot id: A0A452EMW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KBTBD8 family.
messages: Golgi apparatus
messages: spindle

9925:LDB3
gene id: 9925:LDB3
uniprot id: A0A452E1G1
uniprot id: A0A452E1H9
names: Subcellular Location Annotation
messages: Z line

9925:CDNF
gene id: 9925:CDNF
uniprot id: A0A452F8A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARMET family.
messages: Secreted

9925:LOC102181570
gene id: 9925:LOC102181570
uniprot id: A0A452DV78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PTP4A2
gene id: 9925:PTP4A2
uniprot id: A0A452G0Y0
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9925:CFAP36
gene id: 9925:CFAP36
uniprot id: A0A452DUF5
names: Similarity
messages: Belongs to the CFAP36 family.

9925:FAM189A1
gene id: 9925:FAM189A1
uniprot id: A0A452FPR7
names: Similarity
messages: Belongs to the ENTREP family.

9925:FAM229A
gene id: 9925:FAM229A
uniprot id: A0A452ES98
names: Similarity
messages: Belongs to the FAM229 family.

9925:PLBD1
gene id: 9925:PLBD1
uniprot id: A0A452FVJ7
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

9925:ERF
gene id: 9925:ERF
uniprot id: A0A452FAM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9925:SPTSSA
gene id: 9925:SPTSSA
uniprot id: A0A452DY98
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:PACS1
gene id: 9925:PACS1
uniprot id: A0A452FQ37
names: Similarity
messages: Belongs to the PACS family.

9925:OSBPL2
gene id: 9925:OSBPL2
uniprot id: A0A452FL01
names: Similarity
messages: Belongs to the OSBP family.

9925:NOV
gene id: 9925:NOV
uniprot id: A0A452FDV2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:IL1RL1
gene id: 9925:IL1RL1
uniprot id: A0A452EZZ4
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9925:PNRC2
gene id: 9925:PNRC2
uniprot id: A0A8C2Y3Y5
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102181383
gene id: 9925:LOC102181383
uniprot id: A0A452DW09
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:APEX1
gene id: 9925:APEX1
uniprot id: A0A452DU30
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Cytoplasm
messages: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.
messages: Mitochondrion
messages: Nucleus
messages: Probably binds two magnesium or manganese ions per subunit.

9925:LOC102179073
gene id: 9925:LOC102179073
uniprot id: A0A452FBI2
names: Similarity
messages: Belongs to the peptidase A1 family.

9925:KCNA3
gene id: 9925:KCNA3
uniprot id: A0A452DW10
names: Subcellular Location Annotation
messages: Membrane

9925:SIN3A
gene id: 9925:SIN3A
uniprot id: A0A452FFS1
names: Subcellular Location Annotation
messages: Nucleus

9925:KIF3C
gene id: 9925:KIF3C
uniprot id: A0A452DR32
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9925:CCZ1
gene id: 9925:CCZ1
uniprot id: A0A8C2PM16
names: Similarity
messages: Belongs to the CCZ1 family.

9925:CCDC167
gene id: 9925:CCDC167
uniprot id: A0A452FFD6
names: Subcellular Location Annotation
messages: Membrane

9925:DOK5
gene id: 9925:DOK5
uniprot id: A0A452F9V2
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9925:GNG10
gene id: 9925:GNG10
uniprot id: A0A452ERM1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9925:LOC102184170
gene id: 9925:LOC102184170
uniprot id: A0A452E993
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:DPH5
gene id: 9925:DPH5
uniprot id: A0A452FQY7
names: Function
names: Similarity
messages: Belongs to the diphthine synthase family.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.

9925:NHP2
gene id: 9925:NHP2
uniprot id: A0A452EPY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Common component of the spliceosome and rRNA processing machinery.
messages: nucleolus

9925:ADGB
gene id: 9925:ADGB
uniprot id: A0A452G316
names: Caution
names: Similarity
messages: Belongs to the peptidase C2 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102177535
gene id: 9925:LOC102177535
uniprot id: A0A452EDP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SDC4
gene id: 9925:SDC4
uniprot id: A0A452F549
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9925:TEKT5
gene id: 9925:TEKT5
uniprot id: A0A452FIF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9925:CREG2
gene id: 9925:CREG2
uniprot id: A0A452E2T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CREG family.
messages: Secreted

9925:CENPQ
gene id: 9925:CENPQ
uniprot id: A0A452FJV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-Q/OKP1 family.
messages: Nucleus

9925:SRMS
gene id: 9925:SRMS
uniprot id: A0A452EJS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9925:XPOT
gene id: 9925:XPOT
uniprot id: A0A452F514
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm
messages: Nucleus
messages: tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.

9925:TIMP4
gene id: 9925:TIMP4
uniprot id: A0A452F338
names: Similarity
messages: Belongs to the protease inhibitor I35 (TIMP) family.

9925:LOC102177262
gene id: 9925:LOC102177262
uniprot id: A0A452E4R4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:MYH8
gene id: 9925:MYH8
uniprot id: A0A452E4I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: myofibril

9925:KIF21A
gene id: 9925:KIF21A
uniprot id: A0A452G2J0
uniprot id: A0A452G2J3
uniprot id: A0A452G2M8
uniprot id: A0A452G2R3
uniprot id: A0A452G2R5
uniprot id: A0A452G2X3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9925:RUVBL1
gene id: 9925:RUVBL1
uniprot id: A0A452F921
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RuvB family.
messages: Dynein axonemal particle
messages: Nucleus
messages: Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.

9925:EDNRB
gene id: 9925:EDNRB
uniprot id: A0A452E880
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:SMIM5
gene id: 9925:SMIM5
uniprot id: A0A452G5C3
names: Subcellular Location Annotation
messages: Membrane

9925:FFAR2
gene id: 9925:FFAR2
uniprot id: F6KBA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:KDELC2
gene id: 9925:KDELC2
uniprot id: A0A452FHJ0
names: Similarity
messages: Belongs to the KDELC family.

9925:LOC102184416
gene id: 9925:LOC102184416
uniprot id: A0A452DZL7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:KRTAP15-1
gene id: 9925:KRTAP15-1
uniprot id: Q6R645
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9925:TEKT1
gene id: 9925:TEKT1
uniprot id: A0A452FF21
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9925:MCM4
gene id: 9925:MCM4
uniprot id: A0A8C2NWA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9925:LOC102181640
gene id: 9925:LOC102181640
uniprot id: A0A452DW09
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:IRX6
gene id: 9925:IRX6
uniprot id: A0A452FH38
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102179216
gene id: 9925:LOC102179216
uniprot id: A0A8C2NMJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:FBXL5
gene id: 9925:FBXL5
uniprot id: A0A452E6F4
names: Subcellular Location Annotation
messages: perinuclear region

9925:CIAPIN1
gene id: 9925:CIAPIN1
uniprot id: A0A452FER7
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anamorsin family.
messages: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion intermembrane space
messages: Monomer. Interacts with NDOR1. Interacts with CHCHD4.
messages: Nucleus
messages: The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.
messages: The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.
messages: The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

9925:ACTL9
gene id: 9925:ACTL9
uniprot id: A0A452DZ50
names: Similarity
messages: Belongs to the actin family.

9925:LOC102181858
gene id: 9925:LOC102181858
uniprot id: A0A452G0Q1
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:MFAP1
gene id: 9925:MFAP1
uniprot id: A0A452EIU8
names: Function
names: Similarity
messages: Belongs to the MFAP1 family.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.

9925:KRT18
gene id: 9925:KRT18
uniprot id: A0A452FUK7
names: Similarity
messages: Belongs to the intermediate filament family.

9925:RDM1
gene id: 9925:RDM1
uniprot id: A0A452FEB1
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer.
messages: nucleolus

9925:PRDM16
gene id: 9925:PRDM16
uniprot id: A0A452F167
names: Subcellular Location Annotation
messages: Nucleus

9925:SPINK4
gene id: 9925:SPINK4
uniprot id: A0A452E3J7
names: Subcellular Location Annotation
messages: Secreted

9925:PGLYRP2
gene id: 9925:PGLYRP2
uniprot id: A0A452F0C6
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

9925:PPIP5K1
gene id: 9925:PPIP5K1
uniprot id: A0A452DVG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histidine acid phosphatase family. VIP1 subfamily.
messages: Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).
messages: cytosol

9925:PLBD2
gene id: 9925:PLBD2
uniprot id: A0A452G1X4
names: Function
names: Similarity
messages: Belongs to the phospholipase B-like family.
messages: Putative phospholipase.

9925:ETNPPL
gene id: 9925:ETNPPL
uniprot id: A0A452EQ96
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

9925:SLC35C1
gene id: 9925:SLC35C1
uniprot id: A0A452FHB2
names: Subcellular Location Annotation
messages: Membrane

9925:DCLK2
gene id: 9925:DCLK2
uniprot id: A0A452E3T0
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9925:GDPGP1
gene id: 9925:GDPGP1
uniprot id: A0A452DYJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDPGP1 family.
messages: Cytoplasm
messages: Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells.

9925:LOC102173355
gene id: 9925:LOC102173355
uniprot id: A0A452DM94
names: Function
names: Similarity
messages: Belongs to the eukaryotic ATPase epsilon family.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

9925:STK10
gene id: 9925:STK10
uniprot id: A0A452FMS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Cell membrane

9925:NCLN
gene id: 9925:NCLN
uniprot id: A0A452FL43
names: Function
names: Similarity
messages: Belongs to the nicastrin family.
messages: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.

9925:ATP12A
gene id: 9925:ATP12A
uniprot id: A0A452FSL1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:CSNK2B
gene id: 9925:CSNK2B
uniprot id: A0A452EHL5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the casein kinase 2 subunit beta family.
messages: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.
messages: Tetramer of two alpha and two beta subunits.

9925:NDUFB5
gene id: 9925:NDUFB5
uniprot id: A0A452G0J7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB5 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9925:C5AR2
gene id: 9925:C5AR2
uniprot id: A0A452DPM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Membrane

9925:BPI
gene id: 9925:BPI
uniprot id: A0A452EUG7
uniprot id: S5U2L5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

9925:TRHR
gene id: 9925:TRHR
uniprot id: A0A452FH93
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.

9925:CPXM1
gene id: 9925:CPXM1
uniprot id: A0A452FH18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

9925:FAM166A
gene id: 9925:FAM166A
uniprot id: A0A452FAL5
names: Similarity
messages: Belongs to the CIMIP2 family.

9925:EOMES
gene id: 9925:EOMES
uniprot id: A0A452FZG8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9925:HIBADH
gene id: 9925:HIBADH
uniprot id: A0A452E7X5
names: Similarity
messages: Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.

9925:CCK
gene id: 9925:CCK
uniprot id: A0A452F2Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Secreted

9925:GLI3
gene id: 9925:GLI3
uniprot id: A0A452EPR3
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9925:SCFD1
gene id: 9925:SCFD1
uniprot id: A0A452FXC0
names: Similarity
messages: Belongs to the STXBP/unc-18/SEC1 family.

9925:FGF4
gene id: 9925:FGF4
uniprot id: A0A452E3R6
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9925:LOC102186288
gene id: 9925:LOC102186288
uniprot id: A0A452G6B5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9925:PRKCDBP
gene id: 9925:PRKCDBP
uniprot id: A0A452FGE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9925:PLXNA2
gene id: 9925:PLXNA2
uniprot id: A0A452F7F2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the plexin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:SOX2
gene id: 9925:SOX2
uniprot id: H6WS81
names: Subcellular Location Annotation
messages: Nucleus

9925:BCAT1
gene id: 9925:BCAT1
uniprot id: A0A452G0T4
uniprot id: A0A452G1Z3
names: Similarity
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

9925:LOC106503503
gene id: 9925:LOC106503503
uniprot id: A0A452DWU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:CDO1
gene id: 9925:CDO1
uniprot id: A0A452FHB6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the cysteine dioxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.

9925:SESN1
gene id: 9925:SESN1
uniprot id: A0A452F1W9
uniprot id: A0A452F234
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9925:LOC102190535
gene id: 9925:LOC102190535
uniprot id: A0A452E2U7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:BAMBI
gene id: 9925:BAMBI
uniprot id: A0A452EPW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BAMBI family.
messages: Membrane
messages: Negatively regulates TGF-beta signaling.

9925:TPR
gene id: 9925:TPR
uniprot id: A0A452EKT5
names: Similarity
messages: Belongs to the TPR family.

9925:LOC102181138
gene id: 9925:LOC102181138
uniprot id: A0A452E6E1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC100861164
gene id: 9925:LOC100861164
uniprot id: Q6UZ50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:TOR1B
gene id: 9925:TOR1B
uniprot id: A0A452EQZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

9925:POP4
gene id: 9925:POP4
uniprot id: A0A452EWZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Component of nuclear RNase P and RNase MRP.
messages: Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
messages: nucleolus

9925:TPRKB
gene id: 9925:TPRKB
uniprot id: A0A452FL41
names: Similarity
messages: Belongs to the CGI121/TPRKB family.

9925:LPAR2
gene id: 9925:LPAR2
uniprot id: A0A452G6J8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:RPS24
gene id: 9925:RPS24
uniprot id: A0A452DKU0
uniprot id: A0A452DLF2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

9925:GIMAP1
gene id: 9925:GIMAP1
uniprot id: A0A452FXD5
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9925:MED13
gene id: 9925:MED13
uniprot id: A0A452FPL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9925:LOC102173687
gene id: 9925:LOC102173687
uniprot id: A0A452FIB7
names: Similarity
messages: Belongs to the TACO1 family.

9925:GLO1
gene id: 9925:GLO1
uniprot id: A0A452F4X9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the glyoxalase I family.
messages: Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.
messages: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.

9925:SLAIN2
gene id: 9925:SLAIN2
uniprot id: A0A452EGH6
uniprot id: A0A452EGH9
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

9925:LOC102179739
gene id: 9925:LOC102179739
uniprot id: A0A452DNM3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CCBE1
gene id: 9925:CCBE1
uniprot id: A0A452DLM5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:CCNI
gene id: 9925:CCNI
uniprot id: A0A452EPL9
names: Similarity
messages: Belongs to the cyclin family.

9925:PARD3
gene id: 9925:PARD3
uniprot id: A0A452F8H2
uniprot id: A0A452F8N4
uniprot id: A0A452F8N8
uniprot id: A0A452F8R7
uniprot id: A0A452F8W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR3 family.
messages: Cell junction
messages: Endomembrane system

9925:NASP
gene id: 9925:NASP
uniprot id: A0A452EKX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NASP family.
messages: Nucleus

9925:NPL
gene id: 9925:NPL
uniprot id: A0A452FZI2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family. NanA subfamily.
messages: Cytoplasm
messages: Homotetramer.

9925:TRAPPC5
gene id: 9925:TRAPPC5
uniprot id: A0A452DN51
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: May play a role in vesicular transport from endoplasmic reticulum to Golgi.
messages: Part of the multisubunit TRAPP (transport protein particle) complex.
messages: cis-Golgi network

9925:SIRT4
gene id: 9925:SIRT4
uniprot id: A0A452DM46
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to some authors, ADP-ribosyltransferase activity of sirtuins may be an inefficient side reaction of the deacetylase activity and may not be physiologically relevant.
messages: Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion.
messages: Belongs to the sirtuin family. Class II subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Interacts with GLUD1, IDE and SLC25A5. Interacts with DLAT and PDHX.
messages: Mitochondrion matrix

9925:MX1
gene id: 9925:MX1
uniprot id: A0A452DNB0
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9925:VPS54
gene id: 9925:VPS54
uniprot id: A0A452E6E6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS54 family.
messages: trans-Golgi network

9925:AHDC1
gene id: 9925:AHDC1
uniprot id: A0A8C2NFE9
names: Subcellular Location Annotation
messages: Nucleus

9925:ULK1
gene id: 9925:ULK1
uniprot id: A0A452F705
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
messages: Serine/threonine-protein kinase involved in autophagy in response to starvation.

9925:LOC102181096
gene id: 9925:LOC102181096
uniprot id: A0A452DZ42
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9925:LOC102185049
gene id: 9925:LOC102185049
uniprot id: A0A452DR58
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:LOC102184898
gene id: 9925:LOC102184898
uniprot id: A0A452DMH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TNNT2
gene id: 9925:TNNT2
uniprot id: W8FVU0
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9925:GPAT4
gene id: 9925:GPAT4
uniprot id: A0A452FGV6
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9925:PSENEN
gene id: 9925:PSENEN
uniprot id: A0A8C2RAM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEN-2 family.
messages: Golgi stack membrane
messages: Membrane

9925:LOC102185525
gene id: 9925:LOC102185525
uniprot id: A0A452DND2
names: Similarity
messages: Belongs to the CLCR family.

9925:MTX2
gene id: 9925:MTX2
uniprot id: A0A452DXZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metaxin family.
messages: Membrane
messages: Mitochondrion outer membrane

9925:RAX
gene id: 9925:RAX
uniprot id: A0A452ER72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9925:ADAMTS2
gene id: 9925:ADAMTS2
uniprot id: A0A452GAQ5
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:PYROXD1
gene id: 9925:PYROXD1
uniprot id: A0A452FF92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.
messages: sarcomere

9925:PSMG1
gene id: 9925:PSMG1
uniprot id: A0A452DRV4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PSMG1 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.
messages: Cytoplasm
messages: Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits.
messages: Forms a heterodimer with psmg2.

9925:GLB1L
gene id: 9925:GLB1L
uniprot id: A0A452FB33
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9925:EMX1
gene id: 9925:EMX1
uniprot id: A0A452E9L5
names: Subcellular Location Annotation
messages: Nucleus

9925:TIMM13
gene id: 9925:TIMM13
uniprot id: A0A452DPD8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9925:LOC102189985
gene id: 9925:LOC102189985
uniprot id: A0A452EHR2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9925:ABI3
gene id: 9925:ABI3
uniprot id: A0A452G422
names: Similarity
messages: Belongs to the ABI family.

9925:PPM1K
gene id: 9925:PPM1K
uniprot id: A0A452ESG0
names: Similarity
messages: Belongs to the PP2C family.

9925:LOC102173719
gene id: 9925:LOC102173719
uniprot id: A0A452DYS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TMEM170A
gene id: 9925:TMEM170A
uniprot id: A0A452G779
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM170 family.
messages: Membrane

9925:ETS2
gene id: 9925:ETS2
uniprot id: A0A452ERD5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus
messages: Transcription factor.

9925:DDX47
gene id: 9925:DDX47
uniprot id: A0A452G5N4
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.

9925:AP3M2
gene id: 9925:AP3M2
uniprot id: A0A452DL70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus

9925:PERP
gene id: 9925:PERP
uniprot id: A0A452ENR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM47 family.
messages: Membrane

9925:GTDC1
gene id: 9925:GTDC1
uniprot id: A0A452FPS7
names: Similarity
messages: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

9925:PRDM1
gene id: 9925:PRDM1
uniprot id: A0A452FSZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily.
messages: Cytoplasm
messages: Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.
messages: Nucleus
messages: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions.

9925:PTPN11
gene id: 9925:PTPN11
uniprot id: A0A452F960
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
messages: Cytoplasm

9925:C16H1orf158
gene id: 9925:C16H1orf158
uniprot id: A0A452E6F1
names: Function
names: Subcellular Location Annotation
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
messages: cilium axoneme

9925:PRDM2
gene id: 9925:PRDM2
uniprot id: A0A452FT32
uniprot id: A0A452FTE3
uniprot id: A0A452FTH1
names: Subcellular Location Annotation
messages: Nucleus

9925:YPEL2
gene id: 9925:YPEL2
uniprot id: A0A8C2PG61
names: Similarity
messages: Belongs to the yippee family.

9925:GABRA2
gene id: 9925:GABRA2
uniprot id: A0A452G7F4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: dendrite

9925:CXCR5
gene id: 9925:CXCR5
uniprot id: A0A452FFA2
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:HAX1
gene id: 9925:HAX1
uniprot id: A0A452F9L7
names: Function
names: Similarity
messages: Belongs to the HAX1 family.
messages: Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.

9925:LOC102184897
gene id: 9925:LOC102184897
uniprot id: A0A452DSH3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:EHF
gene id: 9925:EHF
uniprot id: A0A452E3W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9925:TGM1
gene id: 9925:TGM1
uniprot id: A0A452FFQ8
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9925:MED31
gene id: 9925:MED31
uniprot id: A0A452DS88
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 31 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9925:MAEL
gene id: 9925:MAEL
uniprot id: A0A452G2G0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the maelstrom family.
messages: Nucleus
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage.

9925:TOP3A
gene id: 9925:TOP3A
uniprot id: A0A452EK54
names: Function
names: Similarity
messages: Belongs to the type IA topoisomerase family.
messages: Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.

9925:TMEM163
gene id: 9925:TMEM163
uniprot id: A0A452G2E1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM163 family.
messages: Membrane
messages: synaptic vesicle membrane

9925:XRCC5
gene id: 9925:XRCC5
uniprot id: A0A452FLL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku80 family.
messages: Nucleus

9925:PRKCB
gene id: 9925:PRKCB
uniprot id: A0A452EYA6
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.
messages: Cytoplasm
messages: Membrane
messages: Nucleus

9925:DLX2
gene id: 9925:DLX2
uniprot id: A0A452FZW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9925:PRLR
gene id: 9925:PRLR
uniprot id: A0A076N3S4
uniprot id: B3GDH0
uniprot id: G1DE70
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 1 subfamily.
messages: Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.
messages: Membrane
messages: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
messages: The box 1 motif is required for JAK interaction and/or activation.
messages: This is a receptor for the anterior pituitary hormone prolactin.

9925:VAMP1
gene id: 9925:VAMP1
uniprot id: A0A8C2NDU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9925:GABRA4
gene id: 9925:GABRA4
uniprot id: A0A452E6Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:KIF18A
gene id: 9925:KIF18A
uniprot id: A0A452DNR5
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9925:RAF1
gene id: 9925:RAF1
uniprot id: A0A452DTI5
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

9925:NMI
gene id: 9925:NMI
uniprot id: A0A452G2A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NMI family.
messages: Cytoplasm
messages: Nucleus
messages: Secreted

9925:MRPS18A
gene id: 9925:MRPS18A
uniprot id: A0A452EEG4
uniprot id: A0A8C2RU57
names: Subcellular Location Annotation
messages: Mitochondrion

9925:MRPL24
gene id: 9925:MRPL24
uniprot id: A0A452ENK2
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9925:SAR1B
gene id: 9925:SAR1B
uniprot id: A0A452FNY5
names: Similarity
messages: Belongs to the small GTPase superfamily. SAR1 family.

9925:PDGFRB
gene id: 9925:PDGFRB
uniprot id: A0A452G073
uniprot id: A0A8C2NFV9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Interacts with homodimeric PDGFB and PDGFD, and with heterodimers formed by PDGFA and PDGFB.
messages: Lysosome lumen
messages: Membrane
messages: Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.
messages: Vesicle

9925:PFKP
gene id: 9925:PFKP
uniprot id: A0A452G0H9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:ZNF202
gene id: 9925:ZNF202
uniprot id: A0A452G944
names: Subcellular Location Annotation
messages: Nucleus

9925:HCRTR2
gene id: 9925:HCRTR2
uniprot id: A0A452DLN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:TMEM30B
gene id: 9925:TMEM30B
uniprot id: A0A452DZN3
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

9925:EIF3G
gene id: 9925:EIF3G
uniprot id: A0A452DPH5
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit G family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts (via C-terminus) with AIFM1 (via N-terminus).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA.
messages: perinuclear region

9925:LOC102191467
gene id: 9925:LOC102191467
uniprot id: A0A452EQE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

9925:DBR1
gene id: 9925:DBR1
uniprot id: A0A452G9X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lariat debranching enzyme family.
messages: Nucleus

9925:HYAL3
gene id: 9925:HYAL3
uniprot id: A0A452EY13
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9925:CDC42BPG
gene id: 9925:CDC42BPG
uniprot id: A0A452F8U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
messages: Cytoplasm

9925:STON1
gene id: 9925:STON1
uniprot id: A0A452EFZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Stoned B family.
messages: Cytoplasm
messages: May be involved in the endocytic machinery.

9925:GDF3
gene id: 9925:GDF3
uniprot id: A0A452E9L3
names: Similarity
messages: Belongs to the TGF-beta family.

9925:HMGCLL1
gene id: 9925:HMGCLL1
uniprot id: A0A452F1Q7
names: Similarity
messages: Belongs to the HMG-CoA lyase family.

9925:TUBAL3
gene id: 9925:TUBAL3
uniprot id: A0A452F9S5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains (PubMed:6504138, PubMed:2207090, PubMed:7704569). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:6504138, PubMed:2207090, PubMed:7704569). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:6504138, PubMed:2207090, PubMed:7704569).
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9925:MOCOS
gene id: 9925:MOCOS
uniprot id: A0A452DN35
names: Function
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.
messages: Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.

9925:LOC108637516
gene id: 9925:LOC108637516
uniprot id: A0A452DT65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ran family.
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: Nucleus

9925:SLC39A12
gene id: 9925:SLC39A12
uniprot id: A0A452FZ83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZIP transporter (TC 2.A.5) family.
messages: Membrane

9925:DRAXIN
gene id: 9925:DRAXIN
uniprot id: A0A8C2XZ07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the draxin family.
messages: Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
messages: Interacts with LRP6.
messages: Secreted

9925:LOC102181164
gene id: 9925:LOC102181164
uniprot id: A0A452E0D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9925:TRAM1L1
gene id: 9925:TRAM1L1
uniprot id: A0A8C2NR13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAM family.
messages: Membrane

9925:CAPN2
gene id: 9925:CAPN2
uniprot id: A0A452F4J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C2 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9925:FDPS
gene id: 9925:FDPS
uniprot id: A0A452FCU2
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9925:PHKB
gene id: 9925:PHKB
uniprot id: A0A452EPM8
uniprot id: A0A452EPW3
uniprot id: A0A452EQM2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphorylase b kinase regulatory chain family.
messages: Cell membrane
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.
messages: Membrane
messages: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.

9925:NUDT18
gene id: 9925:NUDT18
uniprot id: A0A452G3E1
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9925:EAF1
gene id: 9925:EAF1
uniprot id: A0A452G083
names: Similarity
messages: Belongs to the EAF family.

9925:ADK
gene id: 9925:ADK
uniprot id: A0A452DJZ4
uniprot id: A0A452DJZ5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Monomer.
messages: Nucleus

9925:CAPN1
gene id: 9925:CAPN1
uniprot id: F1DAU3
names: Similarity
messages: Belongs to the peptidase C2 family.

9925:EIF4EBP2
gene id: 9925:EIF4EBP2
uniprot id: A0A452DL71
names: Similarity
messages: Belongs to the eIF4E-binding protein family.

9925:MIS18A
gene id: 9925:MIS18A
uniprot id: A0A452DXD1
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

9925:LOC102189098
gene id: 9925:LOC102189098
uniprot id: A0A452E9J0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M67A family. BRCC36 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. In the BRISC complex, interacts directly with ABRAXAS2. Identified in a complex with ABRAXAS2 and NUMA1. The BRISC complex interacts with the CSN complex. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BABAM2 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. Interacts with BRCA1. Binds polyubiquitin. Interacts with PWWP2B. Interacts with HDAC1; this interaction is enhanced in the presence of PWWP2B.
messages: Cytoplasm
messages: Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.
messages: Nucleus
messages: spindle pole

9925:GAB2
gene id: 9925:GAB2
uniprot id: A0A452F0U2
names: Similarity
messages: Belongs to the GAB family.

9925:ILVBL
gene id: 9925:ILVBL
uniprot id: A0A452F3Y6
names: Similarity
messages: Belongs to the TPP enzyme family.

9925:LOC102182655
gene id: 9925:LOC102182655
uniprot id: A0A452FXL1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9925:DAG1
gene id: 9925:DAG1
uniprot id: A0A452ESY5
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.
messages: Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.
messages: cytoskeleton
messages: extracellular space
messages: nucleoplasm
messages: sarcolemma

9925:STAC
gene id: 9925:STAC
uniprot id: A0A452G2X9
names: Subcellular Location Annotation
messages: sarcolemma

9925:MTMR4
gene id: 9925:MTMR4
uniprot id: A0A452FNW8
uniprot id: A0A452FP46
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm
messages: Membrane

9925:PDCL
gene id: 9925:PDCL
uniprot id: A0A452FTY2
names: Similarity
messages: Belongs to the phosducin family.

9925:LOC102190534
gene id: 9925:LOC102190534
uniprot id: A0A452DS58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SGK1
gene id: 9925:SGK1
uniprot id: A0A452E385
uniprot id: A0A452E3B6
uniprot id: A0A8C2R5U1
uniprot id: A0A8C2R682
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm

9925:SLC6A13
gene id: 9925:SLC6A13
uniprot id: A0A452DZ55
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9925:EXOC7
gene id: 9925:EXOC7
uniprot id: A0A452E5L5
uniprot id: A0A452E5P0
uniprot id: A0A452E5Q3
uniprot id: A0A452E5S2
names: Function
names: Similarity
messages: Belongs to the EXO70 family.
messages: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

9925:PAX3
gene id: 9925:PAX3
uniprot id: A0A452FR70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9925:GJA1
gene id: 9925:GJA1
uniprot id: A0A452DQ32
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with SGSM3 (By similarity). Interacts with RIC1/CIP150 (By similarity). Interacts with CNST and CSNK1D (By similarity). Interacts (via C-terminus) with TJP1. Interacts (via C-terminus) with SRC (via SH3 domain). Interacts (not ubiquitinated) with UBQLN4 (via UBA domain) (By similarity). Interacts with NOV. Interacts with TMEM65.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Endoplasmic reticulum
messages: Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles.
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9925:MAB21L1
gene id: 9925:MAB21L1
uniprot id: A0A452E920
names: Similarity
messages: Belongs to the mab-21 family.

9925:TTYH3
gene id: 9925:TTYH3
uniprot id: A0A452E1Q3
uniprot id: A0A452E1Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tweety family.
messages: Cell membrane
messages: Membrane
messages: Probable chloride channel.

9925:WDR91
gene id: 9925:WDR91
uniprot id: A0A8C2NTE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR91 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9925:KIF20A
gene id: 9925:KIF20A
uniprot id: A0A452FTK7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9925:NAGPA
gene id: 9925:NAGPA
uniprot id: A0A452FR72
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:CELSR2
gene id: 9925:CELSR2
uniprot id: A0A452G1Y6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor that may have an important role in cell/cell signaling during nervous system formation.

9925:GCNT1
gene id: 9925:GCNT1
uniprot id: A0A452E6X6
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9925:PAN2
gene id: 9925:PAN2
uniprot id: A0A8C2SG79
names: Activity Regulation
names: Caution
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. PAN2 subfamily.
messages: Binds 2 metal cations per subunit in the catalytic exonuclease domain.
messages: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation.
messages: Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.
messages: Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts with ZFP36.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: P-body
messages: Positively regulated by the regulatory subunit PAN3.
messages: The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.

9925:NEO1
gene id: 9925:NEO1
uniprot id: A0A452E5G5
uniprot id: A0A452E5I9
uniprot id: A0A452E5M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. DCC family.
messages: Membrane

9925:POLR3G
gene id: 9925:POLR3G
uniprot id: A0A452F305
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC7 RNA polymerase subunit family.
messages: Nucleus

9925:GPRIN3
gene id: 9925:GPRIN3
uniprot id: A0A452DW05
names: Function
messages: May be involved in neurite outgrowth.

9925:LOC102181045
gene id: 9925:LOC102181045
uniprot id: A0A452FYB9
uniprot id: A0A8C2NM49
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
messages: Belongs to the IL-1 family.
messages: Secreted

9925:PHYHIP
gene id: 9925:PHYHIP
uniprot id: A0A452E6T2
names: Similarity
messages: Belongs to the PHYHIP family.

9925:FNIP2
gene id: 9925:FNIP2
uniprot id: A0A452F0H8
uniprot id: A0A452F0I1
uniprot id: A0A452F0S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNIP family.
messages: Lysosome membrane
messages: Membrane

9925:IGF2
gene id: 9925:IGF2
uniprot id: A0A8C2SIN2
uniprot id: Q153G7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the insulin family.
messages: Interacts with MYORG; this interaction is required for IGF2 secretion. Interacts with integrins ITGAV:ITGB3 and ITGA6:ITGB4; integrin-binding is required for IGF2 signaling.
messages: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
messages: Secreted
messages: The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate.

9925:FAM171B
gene id: 9925:FAM171B
uniprot id: A0A452E6A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM171 family.
messages: Membrane

9925:LOC102184693
gene id: 9925:LOC102184693
uniprot id: A0A452G6N9
names: Similarity
messages: Belongs to the intermediate filament family.

9925:GNA14
gene id: 9925:GNA14
uniprot id: A0A452FH09
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9925:LOC102189358
gene id: 9925:LOC102189358
uniprot id: A0A452DX52
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:TRMU
gene id: 9925:TRMU
uniprot id: A0A452EYJ2
names: Function
names: Similarity
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.

9925:TES
gene id: 9925:TES
uniprot id: A0A452G6C0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prickle / espinas / testin family.
messages: Cytoplasm
messages: Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer.
messages: Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor.
messages: focal adhesion

9925:MDK
gene id: 9925:MDK
uniprot id: A0A452FGX2
names: Similarity
messages: Belongs to the pleiotrophin family.

9925:MTFR1L
gene id: 9925:MTFR1L
uniprot id: A0A8C2N8Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9925:ESD
gene id: 9925:ESD
uniprot id: A0A452FIG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the esterase D family.
messages: Cytoplasmic vesicle
messages: Serine hydrolase involved in the detoxification of formaldehyde.

9925:MPDZ
gene id: 9925:MPDZ
uniprot id: A0A452FNV2
names: Subcellular Location Annotation
messages: Cell membrane
messages: tight junction

9925:ARSK
gene id: 9925:ARSK
uniprot id: A0A452ETX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Lysosome

9925:AP3M1
gene id: 9925:AP3M1
uniprot id: A0A452DKD6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.

9925:SEC24B
gene id: 9925:SEC24B
uniprot id: A0A452F4C2
uniprot id: A0A452F4N6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9925:IL23A
gene id: 9925:IL23A
uniprot id: A0A452E667
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-6 superfamily.
messages: Secreted

9925:LOC102177596
gene id: 9925:LOC102177596
uniprot id: A0A452DT99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:FSHR
gene id: 9925:FSHR
uniprot id: B5AFX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
messages: Homotrimer. Functions as a homotrimer binding the FSH hormone heterodimer composed of CGA and FSHB (By similarity). Interacts with ARRB2 (By similarity). Interacts with APPL2; interaction is independent of follicle stimulating hormone stimulation.
messages: Membrane

9925:FAM65C
gene id: 9925:FAM65C
uniprot id: A0A452FKU6
names: Similarity
messages: Belongs to the RIPOR family.

9925:FGF14
gene id: 9925:FGF14
uniprot id: A0A452DPR5
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9925:EFHC1
gene id: 9925:EFHC1
uniprot id: A0A452EKG9
names: Subcellular Location Annotation
messages: cilium axoneme

9925:LOC102180749
gene id: 9925:LOC102180749
uniprot id: A0A452G5E5
names: Similarity
messages: Belongs to the copper type II ascorbate-dependent monooxygenase family.

9925:BAIAP2
gene id: 9925:BAIAP2
uniprot id: A0A452EZA6
uniprot id: A0A452EZB2
names: Function
names: Subcellular Location Annotation
messages: Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
messages: Membrane
messages: cytoskeleton
messages: filopodium
messages: ruffle

9925:TAS2R4
gene id: 9925:TAS2R4
uniprot id: A0A452E6S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9925:KIAA0196
gene id: 9925:KIAA0196
uniprot id: A0A452EAS6
names: Similarity
messages: Belongs to the strumpellin family.

9925:DNAJA4
gene id: 9925:DNAJA4
uniprot id: A0A452FX44
names: Subcellular Location Annotation
messages: Membrane

9925:AP1G2
gene id: 9925:AP1G2
uniprot id: A0A452FTZ7
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9925:NLE1
gene id: 9925:NLE1
uniprot id: A0A452EDE5
names: Subcellular Location Annotation
messages: nucleolus

9925:ANTXR1
gene id: 9925:ANTXR1
uniprot id: A0A452FTU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

9925:NFKB2
gene id: 9925:NFKB2
uniprot id: A0A452FBW1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:HEXA
gene id: 9925:HEXA
uniprot id: A0A452FCM6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 20 family.
messages: Lysosome

9925:CDK10
gene id: 9925:CDK10
uniprot id: A0A8C2XUC3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:GABRG2
gene id: 9925:GABRG2
uniprot id: A0A452FNX3
uniprot id: A0A452FP49
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:LOC102169865
gene id: 9925:LOC102169865
uniprot id: A0A452DMX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC108636617
gene id: 9925:LOC108636617
uniprot id: A0A452DN00
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:RNMT
gene id: 9925:RNMT
uniprot id: A0A452DL89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
messages: In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.
messages: Nucleus

9925:DLK1
gene id: 9925:DLK1
uniprot id: A0A0E3M2A0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:FRAT1
gene id: 9925:FRAT1
uniprot id: A0A452DX10
names: Similarity
messages: Belongs to the GSK-3-binding protein family.

9925:E2F8
gene id: 9925:E2F8
uniprot id: A0A452FTQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9925:LCK
gene id: 9925:LCK
uniprot id: A0A452EIH9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9925:AKAP12
gene id: 9925:AKAP12
uniprot id: A0A452EGT7
names: Subcellular Location Annotation
messages: Membrane

9925:LRP5
gene id: 9925:LRP5
uniprot id: A0A452FA21
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LDLR family.
messages: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes.
messages: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:CAMK2N2
gene id: 9925:CAMK2N2
uniprot id: A0A452F3N0
names: Similarity
messages: Belongs to the CAMK2N family.

9925:LOC102177045
gene id: 9925:LOC102177045
uniprot id: A0A452DNA7
names: Similarity
messages: Belongs to the peptidase A1 family.

9925:HSPB3
gene id: 9925:HSPB3
uniprot id: A0A452DNN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Nucleus

9925:PSMB2
gene id: 9925:PSMB2
uniprot id: A0A452EY04
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9925:TFF2
gene id: 9925:TFF2
uniprot id: A0A452G5Z9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:CACNG5
gene id: 9925:CACNG5
uniprot id: A0A452EXY3
names: Similarity
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

9925:NANOS2
gene id: 9925:NANOS2
uniprot id: A0A452ECP9
names: Similarity
messages: Belongs to the nanos family.

9925:FXN
gene id: 9925:FXN
uniprot id: A0A452F8K4
names: Similarity
messages: Belongs to the frataxin family.

9925:HIP1
gene id: 9925:HIP1
uniprot id: A0A8C2S0I2
names: Similarity
messages: Belongs to the SLA2 family.

9925:SH3GL3
gene id: 9925:SH3GL3
uniprot id: A0A452ETZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

9925:C1H3orf70
gene id: 9925:C1H3orf70
uniprot id: A0A452EZD7
names: Similarity
messages: Belongs to the UPF0524 family.

9925:PARVG
gene id: 9925:PARVG
uniprot id: A0A452F0R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: Cell membrane

9925:GTF2H1
gene id: 9925:GTF2H1
uniprot id: A0A452EM76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB1 family.
messages: Nucleus

9925:FBXO46
gene id: 9925:FBXO46
uniprot id: A0A452DXC7
names: Function
messages: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

9925:B3GAT3
gene id: 9925:B3GAT3
uniprot id: A0A452EV34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 43 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:ANXA10
gene id: 9925:ANXA10
uniprot id: A0A452EN54
names: Similarity
messages: Belongs to the annexin family.

9925:NSUN3
gene id: 9925:NSUN3
uniprot id: A0A452ED26
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9925:MCM5
gene id: 9925:MCM5
uniprot id: A0A452E861
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
messages: Belongs to the MCM family.
messages: Chromosome
messages: Component of the MCM2-7 complex.
messages: Nucleus

9925:PDGFC
gene id: 9925:PDGFC
uniprot id: A0A452ET29
names: Caution
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:ENO2
gene id: 9925:ENO2
uniprot id: G9JNA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9925:HOOK3
gene id: 9925:HOOK3
uniprot id: A0A452EUV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

9925:LOC102183616
gene id: 9925:LOC102183616
uniprot id: A0A452EHX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRB/QCR7 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9925:ALG8
gene id: 9925:ALG8
uniprot id: A0A452EQZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:INPPL1
gene id: 9925:INPPL1
uniprot id: A0A452ENQ7
names: Similarity
names: Subcellular Location Annotation
messages: Basal cell membrane
messages: Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
messages: Membrane
messages: Nucleus speckle
messages: filopodium
messages: lamellipodium
messages: spindle pole

9925:LOC102176914
gene id: 9925:LOC102176914
uniprot id: A0A452E2G4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiA prenyltransferase family.
messages: Converts protoheme IX and farnesyl diphosphate to heme O.
messages: Membrane
messages: Mitochondrion membrane

9925:HTR3A
gene id: 9925:HTR3A
uniprot id: A0A452G324
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:CHRNB2
gene id: 9925:CHRNB2
uniprot id: A0A452FAD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:HOXC13
gene id: 9925:HOXC13
uniprot id: A0A2S1UF42
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9925:MYOC
gene id: 9925:MYOC
uniprot id: A0A452EJD6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102191152
gene id: 9925:LOC102191152
uniprot id: A0A452EEK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane

9925:LOC102169846
gene id: 9925:LOC102169846
uniprot id: A0A452G679
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9925:C28H10orf53
gene id: 9925:C28H10orf53
uniprot id: A0A452DT39
names: Similarity
messages: Belongs to the UPF0728 family.

9925:ATP13A5
gene id: 9925:ATP13A5
uniprot id: A0A452E6Y4
uniprot id: A0A452E709
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:TMEM198
gene id: 9925:TMEM198
uniprot id: A0A452FP33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9925:PICK1
gene id: 9925:PICK1
uniprot id: A0A452EA26
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.
messages: cytoskeleton
messages: perinuclear region
messages: synaptosome

9925:ARPC5L
gene id: 9925:ARPC5L
uniprot id: H9TKZ4
names: Function
names: Similarity
messages: Belongs to the ARPC5 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.

9925:SLU7
gene id: 9925:SLU7
uniprot id: A0A452EI82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associated with the spliceosome.
messages: Belongs to the SLU7 family.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

9925:GNGT1
gene id: 9925:GNGT1
uniprot id: A0A8C2N9L4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9925:PHF10
gene id: 9925:PHF10
uniprot id: A0A452FG82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SAYP family.
messages: Nucleus

9925:DHRS7C
gene id: 9925:DHRS7C
uniprot id: A0A452EYQ2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:ATP6V1H
gene id: 9925:ATP6V1H
uniprot id: A0A452EVE9
uniprot id: A0A452EVG7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase H subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9925:NPHS2
gene id: 9925:NPHS2
uniprot id: A0A452DPB8
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9925:VANGL1
gene id: 9925:VANGL1
uniprot id: A0A452E8P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

9925:LOC102181743
gene id: 9925:LOC102181743
uniprot id: A0A452F3S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9925:TBX6
gene id: 9925:TBX6
uniprot id: A0A452EG45
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9925:PRRX2
gene id: 9925:PRRX2
uniprot id: A0A452FYV7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9925:ITGB8
gene id: 9925:ITGB8
uniprot id: A0A452F9L9
uniprot id: A0A452F9X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Melanosome
messages: Membrane
messages: Recycling endosome
messages: focal adhesion
messages: invadopodium membrane
messages: lamellipodium
messages: ruffle membrane

9925:KIF5C
gene id: 9925:KIF5C
uniprot id: A0A452EBH1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9925:CRELD1
gene id: 9925:CRELD1
uniprot id: A0A452EJ30
uniprot id: A0A8C2R508
names: Caution
names: Similarity
messages: Belongs to the CRELD family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:HEXIM1
gene id: 9925:HEXIM1
uniprot id: A0A452DPS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9925:MMP16
gene id: 9925:MMP16
uniprot id: A0A452EG34
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9925:LOC102173552
gene id: 9925:LOC102173552
uniprot id: A0A452F9R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9925:PLAA
gene id: 9925:PLAA
uniprot id: A0A452ENB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PLAP family.
messages: Cytoplasm

9925:MICAL1
gene id: 9925:MICAL1
uniprot id: A0A452EVK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm

9925:SEMA4A
gene id: 9925:SEMA4A
uniprot id: A0A452FQ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Membrane

9925:DYNC1LI1
gene id: 9925:DYNC1LI1
uniprot id: A0A452FZ41
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

9925:ILK
gene id: 9925:ILK
uniprot id: A0A452F0A3
names: Subcellular Location Annotation
messages: focal adhesion
messages: lamellipodium
messages: sarcomere

9925:LOC102185066
gene id: 9925:LOC102185066
uniprot id: A0A452EB66
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:P2RX7
gene id: 9925:P2RX7
uniprot id: A0A452FP31
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P2X receptor family.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9925:VPS51
gene id: 9925:VPS51
uniprot id: A0A452FZM4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the VPS51 family.
messages: Component of the Golgi-associated retrograde protein (GARP) complex. Component of the endosome-associated retrograde protein (EARP) complex.
messages: Endosome
messages: Involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. Acts as component of the EARP complex that is involved in endocytic recycling.
messages: Recycling endosome
messages: trans-Golgi network

9925:PDCD5
gene id: 9925:PDCD5
uniprot id: A0A452DSU1
names: Similarity
messages: Belongs to the PDCD5 family.

9925:CX3CR1
gene id: 9925:CX3CR1
uniprot id: A0A452DUY4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Found in a ternary complex with CX3CL1 and ITGAV:ITGB3 or ITGA4:ITGB1.
messages: Membrane

9925:HARS2
gene id: 9925:HARS2
uniprot id: A0A452E1W1
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9925:MUSTN1
gene id: 9925:MUSTN1
uniprot id: A0A8C2SM57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MUSTANG family.
messages: Nucleus

9925:SGSM1
gene id: 9925:SGSM1
uniprot id: A0A452F2H9
uniprot id: A0A452F2P6
names: Similarity
messages: Belongs to the RUTBC family.

9925:YTHDF3
gene id: 9925:YTHDF3
uniprot id: A0A452G7E6
uniprot id: A0A452G7I1
names: Function
names: Similarity
messages: Belongs to the YTHDF family.
messages: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.

9925:QARS
gene id: 9925:QARS
uniprot id: A0A452FR55
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9925:WLS
gene id: 9925:WLS
uniprot id: A0A452ES79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the wntless family.
messages: Golgi apparatus membrane
messages: Membrane

9925:UGT8
gene id: 9925:UGT8
uniprot id: A0A452F1D2
names: Similarity
messages: Belongs to the UDP-glycosyltransferase family.

9925:LOC102190909
gene id: 9925:LOC102190909
uniprot id: A0A452FKV2
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:SLC9A4
gene id: 9925:SLC9A4
uniprot id: A0A452DPL5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Interacts with CHP1 and CHP2.
messages: Membrane

9925:CXCL8
gene id: 9925:CXCL8
uniprot id: A0A452FCP2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Homodimer.
messages: Secreted

9925:OTOP2
gene id: 9925:OTOP2
uniprot id: A0A452EG55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the otopetrin family.
messages: Cell membrane
messages: Membrane

9925:LOC102172676
gene id: 9925:LOC102172676
uniprot id: A0A452EHW1
names: Similarity
messages: Belongs to the histone H2B family.

9925:LMF1
gene id: 9925:LMF1
uniprot id: A0A452FR12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lipase maturation factor family.
messages: Endoplasmic reticulum membrane
messages: Involved in the maturation of specific proteins in the endoplasmic reticulum.
messages: Membrane

9925:CTLA4
gene id: 9925:CTLA4
uniprot id: A0A8C2NF46
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
messages: Membrane

9925:CTDP1
gene id: 9925:CTDP1
uniprot id: A0A452EVD5
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: This promotes the activity of RNA polymerase II.

9925:CMPK1
gene id: 9925:CMPK1
uniprot id: I6U6S0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
messages: Binds 1 Mg(2+) ion per monomer.
messages: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

9925:CWF19L2
gene id: 9925:CWF19L2
uniprot id: A0A452EFJ2
names: Similarity
messages: Belongs to the CWF19 family.

9925:POLR3A
gene id: 9925:POLR3A
uniprot id: A0A452DLG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA polymerase beta' chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Nucleus

9925:LOC102190090
gene id: 9925:LOC102190090
uniprot id: A0A452ENU5
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102191033
gene id: 9925:LOC102191033
uniprot id: A0A452DUI6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CCM2
gene id: 9925:CCM2
uniprot id: A0A452FDI4
names: Similarity
messages: Belongs to the CCM2 family.

9925:ETV3
gene id: 9925:ETV3
uniprot id: A0A452F2T6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9925:VGLL3
gene id: 9925:VGLL3
uniprot id: A0A8C2N7R0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vestigial family.
messages: May act as a specific coactivator for the mammalian TEFs.
messages: Nucleus

9925:NUDT2
gene id: 9925:NUDT2
uniprot id: A0A452ECY5
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9925:ATP6V0D1
gene id: 9925:ATP6V0D1
uniprot id: A0A452F0M7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9925:CALB2
gene id: 9925:CALB2
uniprot id: A0A452F8K1
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Calretinin is a calcium-binding protein which is abundant in auditory neurons.

9925:SOSTDC1
gene id: 9925:SOSTDC1
uniprot id: A0A452EBH8
names: Caution
names: Similarity
messages: Belongs to the sclerostin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:ABI1
gene id: 9925:ABI1
uniprot id: A0A452EPK2
uniprot id: A0A452EPM3
uniprot id: A0A452EQH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABI family.
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9925:RELL2
gene id: 9925:RELL2
uniprot id: A0A452GA56
names: Similarity
messages: Belongs to the RELT family.

9925:LOC102174383
gene id: 9925:LOC102174383
uniprot id: A0A452E9P3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:AMIGO1
gene id: 9925:AMIGO1
uniprot id: A0A452DM39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Membrane

9925:LOC102179868
gene id: 9925:LOC102179868
uniprot id: A0A452E2T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ORC6
gene id: 9925:ORC6
uniprot id: A0A452FNJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORC6 family.
messages: Nucleus

9925:LOC102184922
gene id: 9925:LOC102184922
uniprot id: A0A452DMQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

9925:POPDC3
gene id: 9925:POPDC3
uniprot id: A0A452EX43
names: Similarity
messages: Belongs to the popeye family.

9925:SCARB2
gene id: 9925:SCARB2
uniprot id: A0A452EI55
names: Similarity
messages: Belongs to the CD36 family.

9925:VANGL2
gene id: 9925:VANGL2
uniprot id: A0A452ESW8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Vang family.
messages: Cell membrane
messages: Membrane

9925:ZNF213
gene id: 9925:ZNF213
uniprot id: A0A452DZG1
names: Subcellular Location Annotation
messages: Nucleus

9925:RAB3A
gene id: 9925:RAB3A
uniprot id: A0A452DUL2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9925:LOC102191624
gene id: 9925:LOC102191624
uniprot id: A0A452DZ30
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Membrane

9925:HSPA2
gene id: 9925:HSPA2
uniprot id: J9QIW8
names: Similarity
messages: Belongs to the heat shock protein 70 family.

9925:LOC102169981
gene id: 9925:LOC102169981
uniprot id: A0A452EAA2
names: Similarity
messages: Belongs to the histone H3 family.

9925:RNF4
gene id: 9925:RNF4
uniprot id: A0A452DPP6
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102169793
gene id: 9925:LOC102169793
uniprot id: A0A452F378
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9925:GCK
gene id: 9925:GCK
uniprot id: A0A452ERT8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hexokinase family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: cytosol

9925:ANXA9
gene id: 9925:ANXA9
uniprot id: A0A452FWB7
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9925:MAK16
gene id: 9925:MAK16
uniprot id: A0A452EYI1
names: Similarity
messages: Belongs to the MAK16 family.

9925:SOX4
gene id: 9925:SOX4
uniprot id: A0A452EGG9
names: Subcellular Location Annotation
messages: Nucleus

9925:SCML4
gene id: 9925:SCML4
uniprot id: A0A452E4Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCM family.
messages: Nucleus

9925:AMDHD2
gene id: 9925:AMDHD2
uniprot id: A0A452ELC6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.
messages: Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.

9925:IGF1
gene id: 9925:IGF1
uniprot id: A0A452F6Z4
uniprot id: A0A452F742
uniprot id: D2DS56
uniprot id: P51457
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the insulin family.
messages: Expressed in all tissues examined: brain, lung, liver, spleen, uterus, ovary, testis, heart and skeletal muscle.
messages: Forms a ternary complex with IGFR1 and ITGAV:ITGB3. Forms a ternary complex with IGFR1 and ITGA6:ITGB4.
messages: Secreted
messages: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).

9925:NCOA3
gene id: 9925:NCOA3
uniprot id: A0A452F2P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9925:RPL32
gene id: 9925:RPL32
uniprot id: A0A452E6T1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

9925:NIPAL2
gene id: 9925:NIPAL2
uniprot id: A0A452ERT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NIPA family.
messages: Membrane

9925:CLDN10
gene id: 9925:CLDN10
uniprot id: A0A452ENS3
uniprot id: A0A452EPB3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9925:FAM96B
gene id: 9925:FAM96B
uniprot id: A0A8C2PFE2
names: Similarity
messages: Belongs to the MIP18 family.

9925:IFNE
gene id: 9925:IFNE
uniprot id: A0A452DVR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:LOC102179556
gene id: 9925:LOC102179556
uniprot id: A0A452EIV7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:B3GNT4
gene id: 9925:B3GNT4
uniprot id: A0A452DYM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:STK32C
gene id: 9925:STK32C
uniprot id: A0A452DK93
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:DYNC1LI2
gene id: 9925:DYNC1LI2
uniprot id: A0A452ELW2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.
messages: Belongs to the dynein light intermediate chain family.
messages: Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).
messages: cytoskeleton

9925:LOC102182725
gene id: 9925:LOC102182725
uniprot id: A0A452DX26
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102182470
gene id: 9925:LOC102182470
uniprot id: A0A452E328
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:NFE2
gene id: 9925:NFE2
uniprot id: A0A452DPL7
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

9925:SBF2
gene id: 9925:SBF2
uniprot id: A0A452FA59
uniprot id: A0A452FAF6
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9925:SMPDL3B
gene id: 9925:SMPDL3B
uniprot id: A0A452EJJ7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acid sphingomyelinase family.
messages: Binds 2 Zn(2+) per subunit.
messages: Secreted

9925:ZNF445
gene id: 9925:ZNF445
uniprot id: A0A452EE84
names: Subcellular Location Annotation
messages: Nucleus

9925:PHOX2B
gene id: 9925:PHOX2B
uniprot id: A0A452F1A0
names: Subcellular Location Annotation
messages: Nucleus

9925:ODF2L
gene id: 9925:ODF2L
uniprot id: A0A452G4Q8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ODF2 family.
messages: centrosome

9925:ST8SIA2
gene id: 9925:ST8SIA2
uniprot id: A0A452EWV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9925:DKK1
gene id: 9925:DKK1
uniprot id: A0A452EMK4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9925:LOC100861197
gene id: 9925:LOC100861197
uniprot id: A0A452EJW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Pi family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Nucleus

9925:CAND2
gene id: 9925:CAND2
uniprot id: A0A452F2J8
names: Similarity
messages: Belongs to the CAND family.

9925:ALG10
gene id: 9925:ALG10
uniprot id: A0A452FT10
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG10 glucosyltransferase family.
messages: Membrane

9925:UBIAD1
gene id: 9925:UBIAD1
uniprot id: A0A452E7T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family.
messages: Membrane

9925:EIF3M
gene id: 9925:EIF3M
uniprot id: A0A452EB00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CSN7/EIF3M family. CSN7 subfamily.
messages: Belongs to the eIF-3 subunit M family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm

9925:PPP3CB
gene id: 9925:PPP3CB
uniprot id: A0A452DJT0
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9925:CACNG6
gene id: 9925:CACNG6
uniprot id: A0A452DVC2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit.

9925:TM4SF1
gene id: 9925:TM4SF1
uniprot id: A0A452EP11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9925:CCM2L
gene id: 9925:CCM2L
uniprot id: A0A452FAI4
names: Similarity
messages: Belongs to the CCM2 family.

9925:LOC102190981
gene id: 9925:LOC102190981
uniprot id: A0A452G4M0
names: Similarity
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Belongs to the intercrine gamma family.

9925:LOC108635997
gene id: 9925:LOC108635997
uniprot id: A0A452G2U2
names: Similarity
messages: Belongs to the intermediate filament family.

9925:LOC102171954
gene id: 9925:LOC102171954
uniprot id: A0A452DT97
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TTI2
gene id: 9925:TTI2
uniprot id: A0A452GAK1
names: Similarity
messages: Belongs to the TTI2 family.

9925:PHF20L1
gene id: 9925:PHF20L1
uniprot id: A0A452DYU8
uniprot id: A0A452DYZ8
names: Subcellular Location Annotation
messages: Nucleus

9925:MRPS12
gene id: 9925:MRPS12
uniprot id: A0A452EIR2
names: Similarity
messages: Belongs to the universal ribosomal protein uS12 family.

9925:ACTN2
gene id: 9925:ACTN2
uniprot id: A0A452E2J7
names: Similarity
messages: Belongs to the alpha-actinin family.

9925:CASQ1
gene id: 9925:CASQ1
uniprot id: A0A452DSM4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

9925:NKX2-8
gene id: 9925:NKX2-8
uniprot id: A0A452FFC7
names: Subcellular Location Annotation
messages: Nucleus

9925:VPS37A
gene id: 9925:VPS37A
uniprot id: A0A452EMZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

9925:LIPE
gene id: 9925:LIPE
uniprot id: A0A452FF98
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'GDXG' lipolytic enzyme family.
messages: Cell membrane
messages: Lipid droplet
messages: caveola
messages: cytosol

9925:FZR1
gene id: 9925:FZR1
uniprot id: A0A452EMH9
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9925:KMT5B
gene id: 9925:KMT5B
uniprot id: A0A452G3F8
names: Subcellular Location Annotation
messages: Chromosome
messages: Nucleus

9925:TNC
gene id: 9925:TNC
uniprot id: A0A452FFT4
uniprot id: A0A452FG92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

9925:PLA2G5
gene id: 9925:PLA2G5
uniprot id: A0A452F8H5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9925:SCNN1G
gene id: 9925:SCNN1G
uniprot id: A0A452F5L2
names: Subcellular Location Annotation
messages: Membrane

9925:NXPH4
gene id: 9925:NXPH4
uniprot id: A0A8C2SA95
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurexophilin family.
messages: May be signaling molecules that resemble neuropeptides.
messages: Secreted

9925:SLC12A2
gene id: 9925:SLC12A2
uniprot id: A0A452GAJ7
uniprot id: A0A452GAK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9925:PRPF38B
gene id: 9925:PRPF38B
uniprot id: A0A452FXL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRP38 family.
messages: May be required for pre-mRNA splicing.
messages: Nucleus

9925:USP3
gene id: 9925:USP3
uniprot id: A0A452FBH1
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9925:ARL5B
gene id: 9925:ARL5B
uniprot id: A0A452G939
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9925:LOC102172284
gene id: 9925:LOC102172284
uniprot id: A0A452E1C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102186299
gene id: 9925:LOC102186299
uniprot id: A0A452EVE4
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9925:LTB4R2
gene id: 9925:LTB4R2
uniprot id: A0A452DSX5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:SF3B6
gene id: 9925:SF3B6
uniprot id: A0A452E1Q5
names: Subcellular Location Annotation
messages: Nucleus

9925:OSBPL11
gene id: 9925:OSBPL11
uniprot id: A0A452G516
names: Similarity
messages: Belongs to the OSBP family.

9925:TPH1
gene id: 9925:TPH1
uniprot id: A0A452FMI3
names: Similarity
messages: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

9925:NRDE2
gene id: 9925:NRDE2
uniprot id: A0A452DS17
names: Similarity
messages: Belongs to the NRDE2 family.

9925:ZDHHC3
gene id: 9925:ZDHHC3
uniprot id: A0A452EZY6
uniprot id: A0A452EZZ6
uniprot id: A0A8C2XWU0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9925:GMFG
gene id: 9925:GMFG
uniprot id: A0A452DMF9
names: Similarity
messages: Belongs to the actin-binding proteins ADF family. GMF subfamily.

9925:CDC42EP2
gene id: 9925:CDC42EP2
uniprot id: A0A452E5G2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system
messages: Probably involved in the organization of the actin cytoskeleton.
messages: cytoskeleton

9925:EN1
gene id: 9925:EN1
uniprot id: A0A452F034
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Engrailed homeobox family.
messages: Nucleus

9925:ALOXE3
gene id: 9925:ALOXE3
uniprot id: A0A452FTY8
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:PBX2
gene id: 9925:PBX2
uniprot id: A0A452FK64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/PBX homeobox family.
messages: Nucleus

9925:QRSL1
gene id: 9925:QRSL1
uniprot id: A0A452F041
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Mitochondrion
messages: Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits.

9925:ENTPD3
gene id: 9925:ENTPD3
uniprot id: A0A452FVN4
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9925:AMD1
gene id: 9925:AMD1
uniprot id: A0A452FCI8
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic AdoMetDC family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.
messages: Heterotetramer of two alpha and two beta chains.

9925:LOC102182127
gene id: 9925:LOC102182127
uniprot id: A0A452E2Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Antiparallel disulfide-linked heterodimer of an alpha chain and a beta chain. Self-associates and forms higher oligomers.
messages: Belongs to the clusterin family.
messages: Endoplasmic reticulum
messages: Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.
messages: Membrane
messages: Microsome
messages: Mitochondrion membrane
messages: Nucleus
messages: Secreted
messages: chromaffin granule
messages: cytosol
messages: perinuclear region

9925:CKB
gene id: 9925:CKB
uniprot id: A0A452F2L8
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9925:LOC102170691
gene id: 9925:LOC102170691
uniprot id: A0A452G1I1
names: Similarity
messages: Belongs to the apolipoprotein L family.

9925:PPFIA2
gene id: 9925:PPFIA2
uniprot id: A0A452FQW3
uniprot id: A0A452FR09
names: Similarity
messages: Belongs to the liprin family. Liprin-alpha subfamily.

9925:PANX2
gene id: 9925:PANX2
uniprot id: A0A452EJ42
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9925:SLC5A7
gene id: 9925:SLC5A7
uniprot id: A0A452FRC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9925:MLEC
gene id: 9925:MLEC
uniprot id: A0A452EL72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the malectin family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:LRRC8E
gene id: 9925:LRRC8E
uniprot id: A0A452FCZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9925:SDHB
gene id: 9925:SDHB
uniprot id: A0A452EG76
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.
messages: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
messages: Mitochondrion inner membrane

9925:CABS1
gene id: 9925:CABS1
uniprot id: A0A452EE04
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Membrane
messages: Mitochondrion inner membrane
messages: flagellum

9925:SLC16A10
gene id: 9925:SLC16A10
uniprot id: A0A452FV81
names: Subcellular Location Annotation
messages: Membrane

9925:GPRC5B
gene id: 9925:GPRC5B
uniprot id: A0A452EYP8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:PPP1R12A
gene id: 9925:PPP1R12A
uniprot id: A0A452DU89
uniprot id: A0A452DUH0
uniprot id: A0A452DUQ9
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

9925:OMA1
gene id: 9925:OMA1
uniprot id: A0A452ER99
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

9925:RAD9A
gene id: 9925:RAD9A
uniprot id: A0A452ELP0
names: Similarity
messages: Belongs to the rad9 family.

9925:TMEM54
gene id: 9925:TMEM54
uniprot id: A0A452DPL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

9925:LOC102183030
gene id: 9925:LOC102183030
uniprot id: A0A452EM69
names: Similarity
messages: Belongs to the universal ribosomal protein uS17 family.

9925:PAXBP1
gene id: 9925:PAXBP1
uniprot id: A0A452FHB9
names: Similarity
messages: Belongs to the GCF family.

9925:LRRC42
gene id: 9925:LRRC42
uniprot id: A0A452FC61
names: Similarity
messages: Belongs to the LRRC42 family.

9925:DKK2
gene id: 9925:DKK2
uniprot id: A0A452G5G3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dickkopf family.
messages: Secreted

9925:HCAR2
gene id: 9925:HCAR2
uniprot id: A0A452E503
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:TRAPPC2L
gene id: 9925:TRAPPC2L
uniprot id: A0A452FR08
uniprot id: A0A8C2RWQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. Sedlin subfamily.
messages: perinuclear region

9925:SMO
gene id: 9925:SMO
uniprot id: A0A452FRY0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: cilium

9925:LOC102189434
gene id: 9925:LOC102189434
uniprot id: A0A452FCP1
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9925:MAN1A2
gene id: 9925:MAN1A2
uniprot id: A0A452EEZ9
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9925:AGO3
gene id: 9925:AGO3
uniprot id: A0A452E977
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argonaute family. Ago subfamily.
messages: Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.

9925:BTC
gene id: 9925:BTC
uniprot id: A0A452FZM7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:YEATS4
gene id: 9925:YEATS4
uniprot id: A0A452ELA2
names: Subcellular Location Annotation
messages: Nucleus

9925:AP3S1
gene id: 9925:AP3S1
uniprot id: A0A452DPL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

9925:TAS2R3
gene id: 9925:TAS2R3
uniprot id: A0A452E5A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor T2R family.
messages: Membrane

9925:MSH6
gene id: 9925:MSH6
uniprot id: A0A452EJX1
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Component of the post-replicative DNA mismatch repair system (MMR).

9925:SLC50A1
gene id: 9925:SLC50A1
uniprot id: A0A0F6T9B8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SWEET sugar transporter family.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates sugar transport across membranes.
messages: Membrane

9925:GSG1L
gene id: 9925:GSG1L
uniprot id: A0A452F2E8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Membrane

9925:HCN2
gene id: 9925:HCN2
uniprot id: A0A452FLF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9925:SLC22A8
gene id: 9925:SLC22A8
uniprot id: A0A452EP37
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9925:DUSP12
gene id: 9925:DUSP12
uniprot id: A0A452GA98
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9925:LOC102176643
gene id: 9925:LOC102176643
uniprot id: A0A452EQU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMN family.
messages: Cajal body
messages: Perikaryon
messages: Z line
messages: gem
messages: neuron projection

9925:ADGRG5
gene id: 9925:ADGRG5
uniprot id: A0A452G708
names: Subcellular Location Annotation
messages: Membrane

9925:VCL
gene id: 9925:VCL
uniprot id: A0A452DKU9
uniprot id: A0A452DLF4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction
messages: podosome

9925:OLFML1
gene id: 9925:OLFML1
uniprot id: A0A452FXE3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102169559
gene id: 9925:LOC102169559
uniprot id: A0A452DMP8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:GLYCTK
gene id: 9925:GLYCTK
uniprot id: A0A452DVW3
names: Similarity
messages: Belongs to the glycerate kinase type-2 family.

9925:HSPA14
gene id: 9925:HSPA14
uniprot id: A0A452FRH2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Component of ribosome-associated complex (RAC), a heterodimer composed of Hsp70/DnaK-type chaperone HSPA14 and Hsp40/DnaJ-type chaperone DNAJC2.
messages: Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity.
messages: cytosol

9925:SLC30A9
gene id: 9925:SLC30A9
uniprot id: A0A452DTD9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Endoplasmic reticulum
messages: Membrane
messages: Mitochondrion membrane
messages: Nucleus

9925:GSG1L2
gene id: 9925:GSG1L2
uniprot id: A0A8C2SBJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSG1 family.
messages: Belongs to the claudin family.
messages: Membrane
messages: tight junction

9925:LOC102185579
gene id: 9925:LOC102185579
uniprot id: A0A452GBI5
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:KRT77
gene id: 9925:KRT77
uniprot id: A0A452ELA7
names: Similarity
messages: Belongs to the intermediate filament family.

9925:SPACA4
gene id: 9925:SPACA4
uniprot id: A0A452E0J6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPACA4/bouncer family.
messages: Cell membrane
messages: Membrane

9925:CCDC58
gene id: 9925:CCDC58
uniprot id: A0A452E516
names: Similarity
messages: Belongs to the MIX23 family.

9925:CMC2
gene id: 9925:CMC2
uniprot id: A0A452EH45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CMC family.
messages: Mitochondrion

9925:PRP6
gene id: 9925:PRP6
uniprot id: A4PBF4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Secreted

9925:FAM47E
gene id: 9925:FAM47E
uniprot id: A0A452G1V6
names: Similarity
messages: Belongs to the FAM47 family.

9925:CTSK
gene id: 9925:CTSK
uniprot id: A0A452E8V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9925:ADCY1
gene id: 9925:ADCY1
uniprot id: A0A452FYH7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9925:LOC102168753
gene id: 9925:LOC102168753
uniprot id: A0A452DM68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CMAS
gene id: 9925:CMAS
uniprot id: A0A452DPA1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CMP-NeuNAc synthase family.
messages: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).
messages: Homotetramer; the active enzyme is formed by a dimer of dimers.

9925:MEIS1
gene id: 9925:MEIS1
uniprot id: A0A452GB18
uniprot id: A0A452GBG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9925:RPS6KA2
gene id: 9925:RPS6KA2
uniprot id: A0A452EVR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
messages: Cytoplasm

9925:MTMR12
gene id: 9925:MTMR12
uniprot id: A0A452DXF4
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9925:SRD5A3
gene id: 9925:SRD5A3
uniprot id: A0A452FA87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).
messages: Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism.

9925:EPO
gene id: 9925:EPO
uniprot id: A0A452G398
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
messages: Secreted

9925:ANO6
gene id: 9925:ANO6
uniprot id: A0A452DMJ2
uniprot id: A0A452DMM5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

9925:ITGA2
gene id: 9925:ITGA2
uniprot id: A0A452G912
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9925:PIGU
gene id: 9925:PIGU
uniprot id: A0A452FZR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGU family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:DGKE
gene id: 9925:DGKE
uniprot id: A0A452FWK5
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9925:LIPG
gene id: 9925:LIPG
uniprot id: A0A8C2R1P4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:SLCO4A1
gene id: 9925:SLCO4A1
uniprot id: A0A452FDL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Membrane

9925:GCNT4
gene id: 9925:GCNT4
uniprot id: A0A452DX01
names: Subcellular Location Annotation
messages: Golgi apparatus membrane
messages: Membrane

9925:MS4A18
gene id: 9925:MS4A18
uniprot id: A0A452EE25
names: Similarity
messages: Belongs to the MS4A family.

9925:ST6GALNAC6
gene id: 9925:ST6GALNAC6
uniprot id: A0A452DMC6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9925:CENPK
gene id: 9925:CENPK
uniprot id: A0A452F1C7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-K/MCM22 family.
messages: Nucleus
messages: centromere

9925:NUP93
gene id: 9925:NUP93
uniprot id: A0A452FKT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin interacting component (NIC) family.
messages: Nucleus membrane
messages: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.
messages: nuclear pore complex

9925:KEAP1
gene id: 9925:KEAP1
uniprot id: A0A452EAU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KEAP1 family.
messages: Cytoplasm
messages: Nucleus

9925:DLX4
gene id: 9925:DLX4
uniprot id: A0A452E643
names: Subcellular Location Annotation
messages: Nucleus

9925:TAAR1
gene id: 9925:TAAR1
uniprot id: A0A8C2QWV9
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:LOC108638228
gene id: 9925:LOC108638228
uniprot id: A0A452DR57
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9925:LOC102183943
gene id: 9925:LOC102183943
uniprot id: A0A452ERU6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:B4GALT3
gene id: 9925:B4GALT3
uniprot id: A0A452F8H0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9925:NUP98
gene id: 9925:NUP98
uniprot id: A0A452EVV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin GLFG family.
messages: Nucleus membrane
messages: nuclear pore complex

9925:VAMP3
gene id: 9925:VAMP3
uniprot id: A0A452EF34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Membrane

9925:MKS1
gene id: 9925:MKS1
uniprot id: A0A452FUL1
names: Subcellular Location Annotation
messages: cilium basal body

9925:ETFDH
gene id: 9925:ETFDH
uniprot id: A0A452FRH5
uniprot id: A0A8C2RYU3
names: Cofactor
names: Function
messages: Accepts electrons from ETF and reduces ubiquinone.
messages: Binds 1 [4Fe-4S] cluster.

9925:NEURL2
gene id: 9925:NEURL2
uniprot id: A0A452FSZ8
names: Subcellular Location Annotation
messages: Cytoplasm

9925:CTSD
gene id: 9925:CTSD
uniprot id: A0A452DRN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Lysosome
messages: extracellular space

9925:LOC102169634
gene id: 9925:LOC102169634
uniprot id: A0A452DZU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family. BCS1 subfamily.
messages: Membrane
messages: Mitochondrion inner membrane

9925:IER2
gene id: 9925:IER2
uniprot id: A0A452DVD0
names: Similarity
messages: Belongs to the IER family.

9925:CRSP-2
gene id: 9925:CRSP-2
uniprot id: B3IWF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcitonin family.
messages: Secreted

9925:PRDM4
gene id: 9925:PRDM4
uniprot id: A0A452F9I6
names: Function
names: Subcellular Location Annotation
messages: May function as a transcription factor involved in cell differentiation.
messages: Nucleus

9925:EPS8
gene id: 9925:EPS8
uniprot id: A0A452DUX9
uniprot id: A0A452DV71
names: Similarity
messages: Belongs to the EPS8 family.

9925:POLR1B
gene id: 9925:POLR1B
uniprot id: A0A452EMC1
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.

9925:TCN1
gene id: 9925:TCN1
uniprot id: A0A452F261
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9925:RXFP4
gene id: 9925:RXFP4
uniprot id: A0A452EDT8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:TLX1
gene id: 9925:TLX1
uniprot id: A0A452EYN0
names: Subcellular Location Annotation
messages: Nucleus

9925:HEXIM2
gene id: 9925:HEXIM2
uniprot id: A0A452DSE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HEXIM family.
messages: Nucleus

9925:ZNF622
gene id: 9925:ZNF622
uniprot id: A0A452DVH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the REI1 family.
messages: Cytoplasm

9925:ERC2
gene id: 9925:ERC2
uniprot id: A0A452DMV8
names: Subcellular Location Annotation
messages: Cytoplasm

9925:C16H1orf174
gene id: 9925:C16H1orf174
uniprot id: A0A452FLP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0688 family.
messages: Nucleus

9925:BCKDK
gene id: 9925:BCKDK
uniprot id: A0A452FNX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDK/BCKDK protein kinase family.
messages: Mitochondrion matrix

9925:PCLO
gene id: 9925:PCLO
uniprot id: A0A452ECR1
names: Subcellular Location Annotation
messages: Presynaptic active zone

9925:CAP1
gene id: 9925:CAP1
uniprot id: A0A452FHV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAP family.
messages: Cell membrane
messages: Membrane

9925:PTGR1
gene id: 9925:PTGR1
uniprot id: A0A452G830
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NADP-dependent oxidoreductase L4BD family.
messages: Cytoplasm
messages: Monomer or homodimer.

9925:AQP9
gene id: 9925:AQP9
uniprot id: A0A452F4R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9925:CDKAL1
gene id: 9925:CDKAL1
uniprot id: A0A452FPK2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. CDKAL1 subfamily.
messages: Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.
messages: Endoplasmic reticulum membrane

9925:EID1
gene id: 9925:EID1
uniprot id: A0A452DV84
names: Subcellular Location Annotation
messages: Nucleus

9925:RAD51
gene id: 9925:RAD51
uniprot id: A0A452G921
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Nucleus
messages: Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair.

9925:LPCAT2
gene id: 9925:LPCAT2
uniprot id: A0A452FKI4
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9925:SEC22B
gene id: 9925:SEC22B
uniprot id: A0A452E2I9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Melanosome
messages: Membrane
messages: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.
messages: cis-Golgi network membrane
messages: trans-Golgi network membrane

9925:FAS
gene id: 9925:FAS
uniprot id: X2KN74
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane raft

9925:RPL14
gene id: 9925:RPL14
uniprot id: A0A452F9G8
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL14 family.

9925:UCKL1
gene id: 9925:UCKL1
uniprot id: A0A8C2NUZ2
names: Similarity
messages: Belongs to the uridine kinase family.

9925:PARP10
gene id: 9925:PARP10
uniprot id: A0A8C2XVX3
names: Similarity
messages: Belongs to the ARTD/PARP family.

9925:TMEM87B
gene id: 9925:TMEM87B
uniprot id: A0A452FR76
names: Subcellular Location Annotation
messages: Membrane

9925:EEF1G
gene id: 9925:EEF1G
uniprot id: A0A452FNW0
names: Function
names: Subunit
messages: EF-1 is composed of four subunits: alpha, beta, delta, and gamma.
messages: Probably plays a role in anchoring the complex to other cellular components.

9925:PABPC4
gene id: 9925:PABPC4
uniprot id: A0A452F9K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyadenylate-binding protein type-1 family.
messages: Binds the poly(A) tail of mRNA.
messages: Cytoplasm

9925:CD247
gene id: 9925:CD247
uniprot id: A0A452DTN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD3Z/FCER1G family.
messages: Cell membrane
messages: Membrane

9925:GOT2
gene id: 9925:GOT2
uniprot id: A0A452EG24
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9925:CCNG2
gene id: 9925:CCNG2
uniprot id: A0A452DNI2
names: Similarity
messages: Belongs to the cyclin family.

9925:PRKAB2
gene id: 9925:PRKAB2
uniprot id: A0A452ETT9
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9925:GPRC5D
gene id: 9925:GPRC5D
uniprot id: T1SHH1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:HIF1A
gene id: 9925:HIF1A
uniprot id: G3LUM4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:ATF1
gene id: 9925:ATF1
uniprot id: A0A452EXG9
uniprot id: A0A452EXH3
names: Subcellular Location Annotation
messages: Nucleus

9925:NEU2
gene id: 9925:NEU2
uniprot id: A0A452FZ46
names: Similarity
messages: Belongs to the glycosyl hydrolase 33 family.

9925:HCAR1
gene id: 9925:HCAR1
uniprot id: A0A452E6W7
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:LOC102173953
gene id: 9925:LOC102173953
uniprot id: A0A452DMN0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:GDAP2
gene id: 9925:GDAP2
uniprot id: A0A452FAG9
names: Similarity
messages: Belongs to the GDAP2 family.

9925:C2H2orf76
gene id: 9925:C2H2orf76
uniprot id: A0A452EZS7
names: Similarity
messages: Belongs to the UPF0538 family.

9925:CTSC
gene id: 9925:CTSC
uniprot id: A0A452EJ14
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C1 family.
messages: Lysosome
messages: Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.

9925:CPNE3
gene id: 9925:CPNE3
uniprot id: A0A452DSF5
names: Similarity
messages: Belongs to the copine family.

9925:AK4
gene id: 9925:AK4
uniprot id: A0A452DUP7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP/ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP/ATP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.
messages: Mitochondrion matrix
messages: Monomer.

9925:WDR4
gene id: 9925:WDR4
uniprot id: A0A452FQC9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat TRM82 family.
messages: Nucleus
messages: Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.

9925:PANX3
gene id: 9925:PANX3
uniprot id: A0A452E5V2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pannexin family.
messages: Cell membrane
messages: Membrane
messages: Structural component of the gap junctions and the hemichannels.
messages: gap junction

9925:OXT
gene id: 9925:OXT
uniprot id: A0A182AUB2
names: Similarity
messages: Belongs to the vasopressin/oxytocin family.

9925:LOC102181844
gene id: 9925:LOC102181844
uniprot id: A0A8C2NEQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TSC22D1
gene id: 9925:TSC22D1
uniprot id: A0A452EBM0
uniprot id: A0A452EC52
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9925:CHML
gene id: 9925:CHML
uniprot id: A0A452DN11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.

9925:LOC102182331
gene id: 9925:LOC102182331
uniprot id: A0A452DPV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SLC6A7
gene id: 9925:SLC6A7
uniprot id: A0A452FLR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9925:DTWD2
gene id: 9925:DTWD2
uniprot id: A0A452EZ06
names: Similarity
messages: Belongs to the TDD superfamily. DTWD2 family.

9925:NCOA2
gene id: 9925:NCOA2
uniprot id: A0A452E5Q1
uniprot id: A0A452E662
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9925:ADCYAP1R1
gene id: 9925:ADCYAP1R1
uniprot id: A0A452DSU8
uniprot id: A0A452DSX2
names: Subcellular Location Annotation
messages: Membrane

9925:IMPDH1
gene id: 9925:IMPDH1
uniprot id: A0A452F2I9
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

9925:CRX
gene id: 9925:CRX
uniprot id: A0A452FR42
names: Subcellular Location Annotation
messages: Nucleus

9925:P2RX3
gene id: 9925:P2RX3
uniprot id: A0A452G0L6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P2X receptor family.
messages: Functional P2XRs are organized as homomeric and heteromeric trimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Receptor for ATP that acts as a ligand-gated ion channel.

9925:PRDM13
gene id: 9925:PRDM13
uniprot id: A0A452DSP9
names: Subcellular Location Annotation
messages: Nucleus

9925:UMOD
gene id: 9925:UMOD
uniprot id: A0A452EQ19
names: Caution
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: cilium membrane

9925:CDH18
gene id: 9925:CDH18
uniprot id: A0A452FDZ8
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9925:ATP6V1C2
gene id: 9925:ATP6V1C2
uniprot id: A0A452EZQ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase C subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits.

9925:STRN3
gene id: 9925:STRN3
uniprot id: A0A452F7F8
uniprot id: A0A452F8A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat striatin family.
messages: Membrane

9925:BRD1
gene id: 9925:BRD1
uniprot id: A0A452EM03
names: Subcellular Location Annotation
messages: Nucleus

9925:RPS6KA1
gene id: 9925:RPS6KA1
uniprot id: A0A452EPI5
uniprot id: A0A452EQI4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
messages: Cytoplasm

9925:HBEGF
gene id: 9925:HBEGF
uniprot id: A0A452FPQ2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:NSF
gene id: 9925:NSF
uniprot id: A0A452EEX0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.

9925:PSMG2
gene id: 9925:PSMG2
uniprot id: A0A452DTJ6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PSMG2 family.
messages: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.
messages: Forms a heterodimer with PSMG1.

9925:ESR1
gene id: 9925:ESR1
uniprot id: A0A452EJX7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Binds DNA as a homodimer.
messages: Membrane
messages: Nucleus
messages: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

9925:RCL1
gene id: 9925:RCL1
uniprot id: A0A452EC56
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.
messages: Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.
messages: nucleolus

9925:LHX9
gene id: 9925:LHX9
uniprot id: A0A452F3Y4
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102189040
gene id: 9925:LOC102189040
uniprot id: A0A452DTY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9925:DPH2
gene id: 9925:DPH2
uniprot id: A0A452DLZ2
names: Function
names: Similarity
messages: Belongs to the DPH1/DPH2 family. DPH2 subfamily.
messages: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.

9925:C14H8orf37
gene id: 9925:C14H8orf37
uniprot id: A0A452G5J6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in photoreceptor outer segment disk morphogenesis.
messages: Photoreceptor inner segment

9925:PREB
gene id: 9925:PREB
uniprot id: A0A452ECP0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat SEC12 family.
messages: Endoplasmic reticulum membrane
messages: Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.
messages: Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus
messages: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.

9925:NQO1
gene id: 9925:NQO1
uniprot id: A0A452G4A1
names: Similarity
messages: Belongs to the NAD(P)H dehydrogenase (quinone) family.

9925:ROCK1
gene id: 9925:ROCK1
uniprot id: A0A452EUH9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activated by RHOA binding. Inhibited by Y-27632.
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Homodimer.
messages: Membrane
messages: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.

9925:PGF
gene id: 9925:PGF
uniprot id: A0A8C2P010
uniprot id: A0A8C2P0S3
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9925:HTR1E
gene id: 9925:HTR1E
uniprot id: A0A452DZJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:LPCAT3
gene id: 9925:LPCAT3
uniprot id: A0A452EN28
names: Subcellular Location Annotation
messages: Membrane

9925:ELAC1
gene id: 9925:ELAC1
uniprot id: A0A452EKJ1
names: Subunit
messages: Homodimer.

9925:SVIL
gene id: 9925:SVIL
uniprot id: A0A452EVS5
names: Similarity
messages: Belongs to the villin/gelsolin family.

9925:TGFB2
gene id: 9925:TGFB2
uniprot id: A0A452FPM4
uniprot id: A0A452FPN4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked.
messages: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
messages: extracellular matrix

9925:DUSP2
gene id: 9925:DUSP2
uniprot id: A0A452G5C5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9925:SYNPR
gene id: 9925:SYNPR
uniprot id: A0A452G6Y4
uniprot id: A0A8C2R5V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptophysin/synaptobrevin family.
messages: Membrane

9925:KCNH3
gene id: 9925:KCNH3
uniprot id: A0A452EHC5
names: Subcellular Location Annotation
names: Subunit
messages: Membrane
messages: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits.

9925:PPP3R1
gene id: 9925:PPP3R1
uniprot id: A0A452DQU4
names: Similarity
messages: Belongs to the calcineurin regulatory subunit family.

9925:CPNE1
gene id: 9925:CPNE1
uniprot id: A0A452G758
names: Similarity
messages: Belongs to the copine family.

9925:SBK1
gene id: 9925:SBK1
uniprot id: A0A452DV88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
messages: Cytoplasm

9925:CNPY2
gene id: 9925:CNPY2
uniprot id: A0A452E9E9
names: Similarity
messages: Belongs to the canopy family.

9925:VKORC1
gene id: 9925:VKORC1
uniprot id: A0A452EKH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VKOR family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:RHO
gene id: 9925:RHO
uniprot id: A0A452F800
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Contains one covalently linked retinal chromophore.
messages: Membrane

9925:LOC108638123
gene id: 9925:LOC108638123
uniprot id: A0A452EP34
names: Subcellular Location Annotation
messages: Nucleus

9925:MB21D1
gene id: 9925:MB21D1
uniprot id: A0A452F4S2
names: Similarity
messages: Belongs to the mab-21 family.

9925:GJB6
gene id: 9925:GJB6
uniprot id: G8Z9I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9925:NUP107
gene id: 9925:NUP107
uniprot id: A0A452G9U2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nucleoporin Nup84/Nup107 family.
messages: Functions as a component of the nuclear pore complex (NPC).
messages: Nucleus membrane
messages: Part of the nuclear pore complex (NPC).
messages: nuclear pore complex

9925:LOC102169908
gene id: 9925:LOC102169908
uniprot id: A0A452DRA9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL33 family.

9925:LOC102181122
gene id: 9925:LOC102181122
uniprot id: A0A452DPU7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:FAM219A
gene id: 9925:FAM219A
uniprot id: A0A8C2NX32
names: Similarity
messages: Belongs to the FAM219 family.

9925:LVRN
gene id: 9925:LVRN
uniprot id: A0A452G0C4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Membrane

9925:AXL
gene id: 9925:AXL
uniprot id: A0A452FDZ2
uniprot id: A0A452FDZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Membrane

9925:LOC102188437
gene id: 9925:LOC102188437
uniprot id: A0A452EFA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CD37
gene id: 9925:CD37
uniprot id: A0A452FVC5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:T
gene id: 9925:T
uniprot id: A0A452E706
uniprot id: A0A8C2R2T7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9925:ATP10A
gene id: 9925:ATP10A
uniprot id: A0A452DU81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9925:TMEM88B
gene id: 9925:TMEM88B
uniprot id: A0A452EML5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM88 family.
messages: Membrane

9925:RAD1
gene id: 9925:RAD1
uniprot id: A0A452EPD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad1 family.
messages: Nucleus

9925:LOC108636029
gene id: 9925:LOC108636029
uniprot id: A0A452DUG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9925:ALDH1L2
gene id: 9925:ALDH1L2
uniprot id: A0A452FAC4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.
messages: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
messages: In the N-terminal section; belongs to the GART family.

9925:MOGS
gene id: 9925:MOGS
uniprot id: A0A452G388
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 63 family.
messages: Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.
messages: Endoplasmic reticulum membrane

9925:SCNN1D
gene id: 9925:SCNN1D
uniprot id: A0A8C2RQ98
names: Subcellular Location Annotation
messages: Membrane

9925:HOXC9
gene id: 9925:HOXC9
uniprot id: A0A452ESK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9925:FEV
gene id: 9925:FEV
uniprot id: A0A452EPV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9925:LOC102175603
gene id: 9925:LOC102175603
uniprot id: A0A452DUK3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:AKIRIN2
gene id: 9925:AKIRIN2
uniprot id: A0A8C2NIV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

9925:GALE
gene id: 9925:GALE
uniprot id: A0A452EKH0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
messages: Homodimer.

9925:DLD
gene id: 9925:DLD
uniprot id: A0A452FWC6
names: Cofactor
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: The active site is a redox-active disulfide bond.
messages: acrosome
messages: flagellum

9925:TSTA3
gene id: 9925:TSTA3
uniprot id: A0A452DX31
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

9925:LOC102182107
gene id: 9925:LOC102182107
uniprot id: A0A452EG43
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LRRFIP1
gene id: 9925:LRRFIP1
uniprot id: A0A452DSK9
names: Similarity
messages: Belongs to the LRRFIP family.

9925:DSG1
gene id: 9925:DSG1
uniprot id: A0A452FC03
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9925:LOC102173289
gene id: 9925:LOC102173289
uniprot id: A0A452DN92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:DHRS7
gene id: 9925:DHRS7
uniprot id: A0A452G765
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:LOC102190297
gene id: 9925:LOC102190297
uniprot id: A0A452G5E7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAMP family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity. Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

9925:RPLP1
gene id: 9925:RPLP1
uniprot id: A0A452E475
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

9925:CNOT7
gene id: 9925:CNOT7
uniprot id: A0A452E9X8
uniprot id: A0A452E9Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9925:C1D
gene id: 9925:C1D
uniprot id: A0A452G4B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the C1D family.
messages: Cytoplasm
messages: Monomer and homodimer.
messages: Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.
messages: nucleolus

9925:MED9
gene id: 9925:MED9
uniprot id: A0A452F023
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 9 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9925:SSBP4
gene id: 9925:SSBP4
uniprot id: A0A452FJS8
names: Subcellular Location Annotation
messages: Nucleus

9925:CPT1A
gene id: 9925:CPT1A
uniprot id: A0A452EPY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9925:SPTBN4
gene id: 9925:SPTBN4
uniprot id: A0A452EPS0
names: Similarity
messages: Belongs to the spectrin family.

9925:NKX2-5
gene id: 9925:NKX2-5
uniprot id: A0A452F0G4
names: Subcellular Location Annotation
messages: Nucleus

9925:CHURC1
gene id: 9925:CHURC1
uniprot id: A0A452EDH9
names: Similarity
messages: Belongs to the Churchill family.

9925:GABARAPL2
gene id: 9925:GABARAPL2
uniprot id: G3EHG8
names: Similarity
messages: Belongs to the ATG8 family.

9925:QPCT
gene id: 9925:QPCT
uniprot id: A0A452EXV2
names: Similarity
messages: Belongs to the glutaminyl-peptide cyclotransferase family.

9925:LOC108633351
gene id: 9925:LOC108633351
uniprot id: A0A452G1M3
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.

9925:LLGL2
gene id: 9925:LLGL2
uniprot id: A0A452EH14
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

9925:ADAMTS9
gene id: 9925:ADAMTS9
uniprot id: A0A452F319
uniprot id: A0A452F339
uniprot id: A0A452F360
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:PFDN6
gene id: 9925:PFDN6
uniprot id: A0A452FHF8
names: Similarity
messages: Belongs to the prefoldin subunit beta family.

9925:SPRTN
gene id: 9925:SPRTN
uniprot id: A0A452EI89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Spartan family.
messages: Chromosome
messages: Nucleus

9925:CACHD1
gene id: 9925:CACHD1
uniprot id: A0A452ECE3
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9925:TSC22D2
gene id: 9925:TSC22D2
uniprot id: A0A452EP85
uniprot id: A0A452EPJ7
names: Similarity
messages: Belongs to the TSC-22/Dip/Bun family.

9925:DCLRE1A
gene id: 9925:DCLRE1A
uniprot id: A0A452EW33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9925:ALDH4A1
gene id: 9925:ALDH4A1
uniprot id: A0A452EUE1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9925:TMOD1
gene id: 9925:TMOD1
uniprot id: A0A452FCT4
names: Subcellular Location Annotation
messages: cytoskeleton

9925:FOXI1
gene id: 9925:FOXI1
uniprot id: A0A452ES08
names: Subcellular Location Annotation
messages: Nucleus

9925:RELL1
gene id: 9925:RELL1
uniprot id: A0A452DRF8
names: Similarity
messages: Belongs to the RELT family.

9925:RPL28
gene id: 9925:RPL28
uniprot id: A0A452G373
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL28 family.

9925:FGD5
gene id: 9925:FGD5
uniprot id: A0A452FUY2
names: Subcellular Location Annotation
messages: cytoskeleton

9925:LOC102174724
gene id: 9925:LOC102174724
uniprot id: A0A452FZQ2
names: Subcellular Location Annotation
messages: Membrane

9925:SEC24D
gene id: 9925:SEC24D
uniprot id: A0A452G372
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9925:LTA
gene id: 9925:LTA
uniprot id: A0A452EMR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.
messages: Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14.
messages: Membrane
messages: Secreted

9925:TLCD2
gene id: 9925:TLCD2
uniprot id: A0A8C2XYX0
names: Subcellular Location Annotation
messages: Membrane

9925:CDS2
gene id: 9925:CDS2
uniprot id: A0A452FIL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
messages: Membrane

9925:GLI1
gene id: 9925:GLI1
uniprot id: A0A452DU66
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9925:PLSCR3
gene id: 9925:PLSCR3
uniprot id: A0A8C2Y3W9
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9925:C17H12orf65
gene id: 9925:C17H12orf65
uniprot id: A0A452FM28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Mitochondrion

9925:NAGK
gene id: 9925:NAGK
uniprot id: A0A452G2N2
names: Similarity
messages: Belongs to the eukaryotic-type N-acetylglucosamine kinase family.

9925:LOC102168949
gene id: 9925:LOC102168949
uniprot id: A0A452E3F9
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9925:DPF1
gene id: 9925:DPF1
uniprot id: A0A452E518
names: Similarity
messages: Belongs to the requiem/DPF family.

9925:SRPRB
gene id: 9925:SRPRB
uniprot id: A0A452FB30
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP receptor beta subunit family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:TAS1R2
gene id: 9925:TAS1R2
uniprot id: A0A452FBZ8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:KCNK7
gene id: 9925:KCNK7
uniprot id: A0A452FAZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9925:RFLNB
gene id: 9925:RFLNB
uniprot id: A0A452G8J6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Refilin family.
messages: Interacts with FLNA and FLNB.
messages: cytoskeleton

9925:BCL7C
gene id: 9925:BCL7C
uniprot id: A0A452EHJ2
uniprot id: A0A8C2SHW9
names: Similarity
messages: Belongs to the BCL7 family.

9925:CHSY1
gene id: 9925:CHSY1
uniprot id: A0A452G6I2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9925:GMPR2
gene id: 9925:GMPR2
uniprot id: A0A452E631
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

9925:NR1H4
gene id: 9925:NR1H4
uniprot id: A0A452FGU4
uniprot id: A0A452FGV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9925:UBXN1
gene id: 9925:UBXN1
uniprot id: A0A452DTL6
names: Subcellular Location Annotation
messages: Cytoplasm

9925:JPH3
gene id: 9925:JPH3
uniprot id: A0A452FAG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the junctophilin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.
messages: Membrane

9925:SLC25A45
gene id: 9925:SLC25A45
uniprot id: A0A452ERJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:RAB3IL1
gene id: 9925:RAB3IL1
uniprot id: A0A452F3P9
uniprot id: A0A452F3X5
names: Similarity
messages: Belongs to the SEC2 family.

9925:LOC102179480
gene id: 9925:LOC102179480
uniprot id: A0A452EGY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:EIF3A
gene id: 9925:EIF3A
uniprot id: A0A452EWF9
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit A family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3L and EIF3K. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with EIF4G1. Also interacts with KRT7 and PIWIL2.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

9925:SRP54
gene id: 9925:SRP54
uniprot id: A0A452G776
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1. Interacts with the SRP receptor subunit SRPRA.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Nucleus speckle
messages: The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.
messages: The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

9925:ALOX5
gene id: 9925:ALOX5
uniprot id: A0A452FR96
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:KCNAB2
gene id: 9925:KCNAB2
uniprot id: A0A452FNV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shaker potassium channel beta subunit family.
messages: Cell membrane
messages: Membrane
messages: axon
messages: cytoskeleton
messages: synaptosome

9925:BOK
gene id: 9925:BOK
uniprot id: A0A452G7C4
names: Similarity
messages: Belongs to the Bcl-2 family.

9925:LOC102176896
gene id: 9925:LOC102176896
uniprot id: A0A452ESQ4
uniprot id: A0A8C2R4W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
messages: Nucleus

9925:NAGLU
gene id: 9925:NAGLU
uniprot id: A0A452G3T7
names: Subcellular Location Annotation
messages: Lysosome

9925:LOC102172438
gene id: 9925:LOC102172438
uniprot id: A0A452F5X5
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:MRPL54
gene id: 9925:MRPL54
uniprot id: A0A452G822
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL54 family.
messages: Mitochondrion

9925:KCNMB1
gene id: 9925:KCNMB1
uniprot id: A0A452EUN6
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the KCNMB (TC 8.A.14.1) family.
messages: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.
messages: Membrane
messages: N-glycosylated.
messages: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

9925:DDR2
gene id: 9925:DDR2
uniprot id: A0A452FL91
names: Subcellular Location Annotation
messages: Membrane

9925:PCNX3
gene id: 9925:PCNX3
uniprot id: A0A8C2S1N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9925:GRIN1
gene id: 9925:GRIN1
uniprot id: A0A452EUI9
uniprot id: A0A452EUP4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9925:THNSL2
gene id: 9925:THNSL2
uniprot id: A0A452FDG6
names: Similarity
messages: Belongs to the threonine synthase family.

9925:LOC102168295
gene id: 9925:LOC102168295
uniprot id: A0A452DSW4
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9925:PSMB6
gene id: 9925:PSMB6
uniprot id: A0A452FSD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9925:GDF15
gene id: 9925:GDF15
uniprot id: A0A452GBA5
names: Similarity
messages: Belongs to the TGF-beta family.

9925:CADM4
gene id: 9925:CADM4
uniprot id: A0A452FQ85
names: Similarity
messages: Belongs to the nectin family.

9925:ALKBH1
gene id: 9925:ALKBH1
uniprot id: A0A452F2T9
names: Cofactor
messages: Binds 1 Fe(2+) ion per subunit.

9925:HTRA2
gene id: 9925:HTRA2
uniprot id: A0A452EDF2
names: Similarity
messages: Belongs to the peptidase S1C family.

9925:LOC102171353
gene id: 9925:LOC102171353
uniprot id: A0A452E8M9
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:MYB
gene id: 9925:MYB
uniprot id: A0A452E252
uniprot id: A0A8C2R9N5
uniprot id: A0A8C2R9U4
names: Subcellular Location Annotation
messages: Nucleus

9925:OTX1
gene id: 9925:OTX1
uniprot id: A0A452F345
names: Subcellular Location Annotation
messages: Nucleus

9925:SF1
gene id: 9925:SF1
uniprot id: A0A452G4Y3
uniprot id: A0A452G505
uniprot id: A0A8C2R2C2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BBP/SF1 family.
messages: Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.
messages: Nucleus

9925:CDK8
gene id: 9925:CDK8
uniprot id: A0A452DSU4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:SLC35A1
gene id: 9925:SLC35A1
uniprot id: A0A452F3M2
uniprot id: A0A8C2NPT4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9925:OCA2
gene id: 9925:OCA2
uniprot id: A0A452G2F2
names: Subcellular Location Annotation
messages: Membrane

9925:METAP1
gene id: 9925:METAP1
uniprot id: A0A452FLJ9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

9925:CAB39L
gene id: 9925:CAB39L
uniprot id: A0A452FEY0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

9925:SCRN1
gene id: 9925:SCRN1
uniprot id: A0A452FSS9
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9925:LLPH
gene id: 9925:LLPH
uniprot id: A0A452F7S4
names: Similarity
messages: Belongs to the learning-associated protein family.

9925:NME4
gene id: 9925:NME4
uniprot id: A0A452FUA1
names: Similarity
messages: Belongs to the NDK family.

9925:DHX15
gene id: 9925:DHX15
uniprot id: A0A452G744
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.

9925:SNAP91
gene id: 9925:SNAP91
uniprot id: A0A452FLY4
names: Similarity
messages: Belongs to the PICALM/SNAP91 family.

9925:ITPR2
gene id: 9925:ITPR2
uniprot id: A0A452EWP8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the InsP3 receptor family.
messages: Endoplasmic reticulum membrane
messages: Homotetramer.
messages: Membrane
messages: Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
messages: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

9925:SLC6A19
gene id: 9925:SLC6A19
uniprot id: A0A452DZC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9925:CDX1
gene id: 9925:CDX1
uniprot id: A0A452FQD0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9925:OSBPL1A
gene id: 9925:OSBPL1A
uniprot id: A0A452DL29
names: Similarity
messages: Belongs to the OSBP family.

9925:SEMA3E
gene id: 9925:SEMA3E
uniprot id: A0A452FBI5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:KXD1
gene id: 9925:KXD1
uniprot id: A0A452GAM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KXD1 family.
messages: Lysosome membrane

9925:LOC102181115
gene id: 9925:LOC102181115
uniprot id: A0A452DX12
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102179758
gene id: 9925:LOC102179758
uniprot id: A0A452DZ62
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:RNF40
gene id: 9925:RNF40
uniprot id: A0A452DWC5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BRE1 family.
messages: Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.
messages: Nucleus

9925:LOC102181391
gene id: 9925:LOC102181391
uniprot id: A0A452DPF0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:UBN1
gene id: 9925:UBN1
uniprot id: A0A452FWD1
names: Similarity
messages: Belongs to the ubinuclein family.

9925:DLX1
gene id: 9925:DLX1
uniprot id: A0A452EKR5
names: Subcellular Location Annotation
messages: Nucleus

9925:AQP7
gene id: 9925:AQP7
uniprot id: A0A452DNC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9925:TMED10
gene id: 9925:TMED10
uniprot id: A0A452FNM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:BNIP1
gene id: 9925:BNIP1
uniprot id: A0A452DVN7
names: Subcellular Location Annotation
messages: Membrane

9925:NR5A1
gene id: 9925:NR5A1
uniprot id: A0A452FC16
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR5 subfamily.
messages: Nucleus

9925:DPF2
gene id: 9925:DPF2
uniprot id: A1E461
names: Similarity
messages: Belongs to the requiem/DPF family.

9925:NOTUM
gene id: 9925:NOTUM
uniprot id: A0A452EZP0
names: Similarity
messages: Belongs to the pectinacetylesterase family. Notum subfamily.

9925:CELF1
gene id: 9925:CELF1
uniprot id: A0A452FYG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CELF/BRUNOL family.
messages: Cytoplasm
messages: Nucleus

9925:LOC102170564
gene id: 9925:LOC102170564
uniprot id: A0A452FFP7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9925:SLC4A4
gene id: 9925:SLC4A4
uniprot id: A0A452FA81
uniprot id: A0A452FAC2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: Membrane

9925:CD2
gene id: 9925:CD2
uniprot id: A0A452FT63
names: Subcellular Location Annotation
messages: Membrane

9925:KCNG1
gene id: 9925:KCNG1
uniprot id: A0A452FU51
names: Subcellular Location Annotation
messages: Membrane

9925:ESRRA
gene id: 9925:ESRRA
uniprot id: A0A452EQJ7
uniprot id: A0A8C2PMM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9925:ACSM5
gene id: 9925:ACSM5
uniprot id: A0A452EMS4
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9925:MMP7
gene id: 9925:MMP7
uniprot id: A0A452G7R9
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9925:LHX5
gene id: 9925:LHX5
uniprot id: A0A452FRA4
names: Subcellular Location Annotation
messages: Nucleus

9925:THRAP3
gene id: 9925:THRAP3
uniprot id: A0A452FQG3
names: Similarity
messages: Belongs to the BCLAF1/THRAP3 family.

9925:PPP4R3B
gene id: 9925:PPP4R3B
uniprot id: A0A452E2N7
names: Similarity
messages: Belongs to the SMEK family.

9925:MTFR1
gene id: 9925:MTFR1
uniprot id: A0A452FQV9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9925:POLD2
gene id: 9925:POLD2
uniprot id: A0A452E0V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Nucleus

9925:PPP1R16B
gene id: 9925:PPP1R16B
uniprot id: A0A452ECE9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:LOC102179687
gene id: 9925:LOC102179687
uniprot id: A0A452E0Y9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PREPL
gene id: 9925:PREPL
uniprot id: A0A452G204
names: Similarity
messages: Belongs to the peptidase S9A family.

9925:ZDHHC23
gene id: 9925:ZDHHC23
uniprot id: A0A452EI07
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9925:CAMK1D
gene id: 9925:CAMK1D
uniprot id: A0A452DU38
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:ARAP2
gene id: 9925:ARAP2
uniprot id: A0A452EJR4
uniprot id: A0A452EK09
names: Subcellular Location Annotation
messages: Cytoplasm

9925:ZNF444
gene id: 9925:ZNF444
uniprot id: A0A452EQ76
names: Subcellular Location Annotation
messages: Nucleus

9925:ANXA1
gene id: 9925:ANXA1
uniprot id: A0A452FG03
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the annexin family.
messages: Cell membrane
messages: Early endosome
messages: Endosome
messages: Lateral cell membrane
messages: Membrane
messages: Nucleus
messages: The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.
messages: cilium
messages: extracellular exosome
messages: extracellular space
messages: phagocytic cup
messages: secretory vesicle lumen

9925:NR4A1
gene id: 9925:NR4A1
uniprot id: A0A452E0F2
uniprot id: A0A8C2S204
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR4 subfamily.
messages: In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7.
messages: Nucleus
messages: cytosol

9925:GJC1
gene id: 9925:GJC1
uniprot id: A0A452DY69
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins. Interacts with CNST.
messages: Belongs to the connexin family. Gamma-type subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9925:B4GALT7
gene id: 9925:B4GALT7
uniprot id: A0A452F2C7
uniprot id: A0A8C2NRD4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9925:DCTN2
gene id: 9925:DCTN2
uniprot id: A0A452FJ27
uniprot id: A0A8C2S6D2
names: Similarity
messages: Belongs to the dynactin subunit 2 family.

9925:GTF2A2
gene id: 9925:GTF2A2
uniprot id: A0A452EPF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFIIA subunit 2 family.
messages: Nucleus
messages: TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.

9925:TNFRSF4
gene id: 9925:TNFRSF4
uniprot id: A0A452FBG5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:CRISP2
gene id: 9925:CRISP2
uniprot id: A0A452DZW1
uniprot id: D6PX61
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:TMEM98
gene id: 9925:TMEM98
uniprot id: A0A452GA84
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM98 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: extracellular exosome

9925:LOC102169688
gene id: 9925:LOC102169688
uniprot id: A0A452E8S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ITGAM
gene id: 9925:ITGAM
uniprot id: A0A452EK18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9925:ITPKC
gene id: 9925:ITPKC
uniprot id: A0A452GBC7
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9925:ZC3H15
gene id: 9925:ZC3H15
uniprot id: A0A8C2PMZ5
names: Similarity
messages: Belongs to the ZC3H15/TMA46 family.

9925:RDX
gene id: 9925:RDX
uniprot id: A0A452FA94
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton
messages: microvillus

9925:CLIP1
gene id: 9925:CLIP1
uniprot id: A0A452FNI0
names: Subcellular Location Annotation
messages: cytoskeleton

9925:RIOK2
gene id: 9925:RIOK2
uniprot id: A0A452EWW4
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

9925:GRB7
gene id: 9925:GRB7
uniprot id: A0A452GBL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GRB7/10/14 family.
messages: Cytoplasm

9925:MED11
gene id: 9925:MED11
uniprot id: A0A8C2SBZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 11 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9925:ZYG11B
gene id: 9925:ZYG11B
uniprot id: A0A452DM72
names: Similarity
messages: Belongs to the zyg-11 family.

9925:TSSK6
gene id: 9925:TSSK6
uniprot id: A0A452EEA4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:STC1
gene id: 9925:STC1
uniprot id: A0A452E500
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9925:LOC102187154
gene id: 9925:LOC102187154
uniprot id: A0A452G6M6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UQCR10/QCR9 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
messages: Membrane
messages: Mitochondrion inner membrane

9925:LIMK1
gene id: 9925:LIMK1
uniprot id: A0A452GB28
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

9925:ADSSL1
gene id: 9925:ADSSL1
uniprot id: A0A452F4G4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
messages: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis.

9925:TRAPPC1
gene id: 9925:TRAPPC1
uniprot id: A0A452EHV5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9925:GALNT6
gene id: 9925:GALNT6
uniprot id: A0A452EZ78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9925:SLC7A8
gene id: 9925:SLC7A8
uniprot id: A0A452DTW3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Cell membrane
messages: Membrane

9925:HTR2A
gene id: 9925:HTR2A
uniprot id: A0A452EXR6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: G-protein coupled receptor for 5-hydroxytryptamine (serotonin).
messages: Membrane
messages: Presynapse
messages: Synapse
messages: Vesicle
messages: axon
messages: caveola
messages: dendrite

9925:MYBBP1A
gene id: 9925:MYBBP1A
uniprot id: A0A452F3T9
names: Similarity
messages: Belongs to the MYBBP1A family.

9925:CHD6
gene id: 9925:CHD6
uniprot id: A0A452F1D1
names: Similarity
messages: Belongs to the SNF2/RAD54 helicase family.

9925:PEX14
gene id: 9925:PEX14
uniprot id: A0A8C2Y0E6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-14 family.
messages: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.
messages: Peroxisome membrane

9925:ST8SIA3
gene id: 9925:ST8SIA3
uniprot id: A0A452FF14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9925:ANKRD13D
gene id: 9925:ANKRD13D
uniprot id: A0A452G9B6
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

9925:GABBR2
gene id: 9925:GABBR2
uniprot id: A0A452G051
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

9925:TIPIN
gene id: 9925:TIPIN
uniprot id: A0A452DLQ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSM3 family.
messages: Nucleus
messages: Plays an important role in the control of DNA replication and the maintenance of replication fork stability.

9925:DLX3
gene id: 9925:DLX3
uniprot id: A0A452E4Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the distal-less homeobox family.
messages: Nucleus

9925:HOXD8
gene id: 9925:HOXD8
uniprot id: A0A452EG99
names: Subcellular Location Annotation
messages: Nucleus

9925:FER
gene id: 9925:FER
uniprot id: A0A452EVE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.
messages: Cell membrane
messages: Membrane
messages: cytoskeleton

9925:SMARCA2
gene id: 9925:SMARCA2
uniprot id: A0A452G549
uniprot id: A0A452G553
uniprot id: A0A452G579
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9925:ELK3
gene id: 9925:ELK3
uniprot id: A0A452FF00
uniprot id: A0A8C2NDL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9925:SUGP1
gene id: 9925:SUGP1
uniprot id: A0A452FX71
names: Subcellular Location Annotation
messages: Nucleus

9925:SLC28A3
gene id: 9925:SLC28A3
uniprot id: A0A452F2T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.
messages: Membrane

9925:BMP6
gene id: 9925:BMP6
uniprot id: A0A452G7Z3
names: Similarity
messages: Belongs to the TGF-beta family.

9925:CLDN11
gene id: 9925:CLDN11
uniprot id: A0A452E6K8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9925:NAA38
gene id: 9925:NAA38
uniprot id: A0A452FUH6
uniprot id: A0A8C2RQU0
names: Function
names: Similarity
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.
messages: Belongs to the snRNP Sm proteins family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.

9925:ATRN
gene id: 9925:ATRN
uniprot id: A0A452G9E8
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:CBL
gene id: 9925:CBL
uniprot id: A0A452DW08
uniprot id: A0A452DW21
names: Domain
names: Function
messages: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
messages: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.

9925:SNAP23
gene id: 9925:SNAP23
uniprot id: A0A452DUG3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: synaptosome

9925:GSTO2
gene id: 9925:GSTO2
uniprot id: A0A452DP64
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9925:LOC106501735
gene id: 9925:LOC106501735
uniprot id: A0A452DN87
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PIGO
gene id: 9925:PIGO
uniprot id: A0A452EIR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:NEK7
gene id: 9925:NEK7
uniprot id: A0A452ENX3
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:FAXC
gene id: 9925:FAXC
uniprot id: A0A452E2T7
names: Similarity
messages: Belongs to the FAX family.

9925:ELP6
gene id: 9925:ELP6
uniprot id: A0A8C2SEH4
names: Similarity
messages: Belongs to the ELP6 family.

9925:RPS14
gene id: 9925:RPS14
uniprot id: A0A452ECV2
names: Similarity
messages: Belongs to the universal ribosomal protein uS11 family.

9925:GOT1
gene id: 9925:GOT1
uniprot id: A0A452FY52
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
messages: Homodimer.
messages: In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.

9925:HOXD10
gene id: 9925:HOXD10
uniprot id: A0A452E9H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9925:FOXK1
gene id: 9925:FOXK1
uniprot id: A0A452FGJ6
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102175500
gene id: 9925:LOC102175500
uniprot id: A0A452F1T9
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9925:MRPL50
gene id: 9925:MRPL50
uniprot id: A0A452EPU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL50 family.
messages: Mitochondrion

9925:GLI2
gene id: 9925:GLI2
uniprot id: A0A452F0Y2
uniprot id: A0A452F108
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9925:LOC102175795
gene id: 9925:LOC102175795
uniprot id: A0A452FJ15
names: Similarity
messages: Belongs to the NDK family.

9925:POLR2B
gene id: 9925:POLR2B
uniprot id: A0A452E652
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9925:CDX2
gene id: 9925:CDX2
uniprot id: A0A452G0A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Caudal homeobox family.
messages: Nucleus

9925:WT1
gene id: 9925:WT1
uniprot id: A0A452EEJ8
uniprot id: A0A452EET1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Cytoplasm
messages: Nucleus speckle

9925:LOC102190919
gene id: 9925:LOC102190919
uniprot id: A0A452FDW5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

9925:TSPAN16
gene id: 9925:TSPAN16
uniprot id: A0A8C2PI07
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:XPA
gene id: 9925:XPA
uniprot id: A0A452E499
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPA family.
messages: Nucleus

9925:ZFPL1
gene id: 9925:ZFPL1
uniprot id: A0A8C2XXE7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ZFPL1 family.
messages: Interacts with GOLGA2/GM130.
messages: Membrane
messages: Required for cis-Golgi integrity and efficient ER to Golgi transport.
messages: The B box-type and RING-type zinc fingers although degenerate play a central role in function of the protein.
messages: cis-Golgi network membrane

9925:SLC25A42
gene id: 9925:SLC25A42
uniprot id: A0A452EZG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:TYRP1
gene id: 9925:TYRP1
uniprot id: Q9XSG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosinase family.
messages: Melanosome membrane

9925:LOC102175225
gene id: 9925:LOC102175225
uniprot id: A0A452EFZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

9925:PPIL1
gene id: 9925:PPIL1
uniprot id: A0A452EJ98
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9925:CALCRL
gene id: 9925:CALCRL
uniprot id: A0A452EBB5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Heterodimer of CALCRL and RAMP1, RAMP2 or RAMP3.
messages: Membrane
messages: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9925:MED17
gene id: 9925:MED17
uniprot id: A0A452EKU9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 17 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9925:EIF4E2
gene id: 9925:EIF4E2
uniprot id: A0A452FJ66
uniprot id: A0A8C2N8Y4
names: Similarity
messages: Belongs to the eukaryotic initiation factor 4E family.

9925:MFSD11
gene id: 9925:MFSD11
uniprot id: A0A452G366
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-93 family.
messages: Membrane

9925:MRPL2
gene id: 9925:MRPL2
uniprot id: A0A452F0F9
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9925:KITLG
gene id: 9925:KITLG
uniprot id: Q95M19
uniprot id: T2B8G0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A soluble form is produced by proteolytic processing of the extracellular domain.
messages: Belongs to the SCF family.
messages: Cell membrane
messages: Cytoplasm
messages: Homodimer, non-covalently linked.
messages: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.
messages: Secreted
messages: Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity).
messages: cytoskeleton
messages: filopodium
messages: lamellipodium

9925:BDH1
gene id: 9925:BDH1
uniprot id: A0A452G711
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:LMOD2
gene id: 9925:LMOD2
uniprot id: A0A452FVX8
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

9925:RHCG
gene id: 9925:RHCG
uniprot id: A0A452EWE6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9925:CLDN3
gene id: 9925:CLDN3
uniprot id: A0A452DQ99
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the claudin family.
messages: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9925:RBX1
gene id: 9925:RBX1
uniprot id: A0A452G412
names: Similarity
messages: Belongs to the RING-box family.

9925:LOC102181962
gene id: 9925:LOC102181962
uniprot id: A0A452EHF7
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9925:CCL26
gene id: 9925:CCL26
uniprot id: A0A452FTU8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9925:DNASE2
gene id: 9925:DNASE2
uniprot id: A0A452F4G7
names: Similarity
messages: Belongs to the DNase II family.

9925:TRUB2
gene id: 9925:TRUB2
uniprot id: A0A452FH64
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9925:PPP2R5B
gene id: 9925:PPP2R5B
uniprot id: A0A452EZE3
names: Function
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B56 family.
messages: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

9925:LOC102185056
gene id: 9925:LOC102185056
uniprot id: A0A452EF31
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.
messages: Membrane
messages: Microsome membrane
messages: Mitochondrion inner membrane
messages: The omega-1 hydroxylase activity is stimulated by cytochrome b5.

9925:LPGAT1
gene id: 9925:LPGAT1
uniprot id: A0A452F5J5
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9925:INSM1
gene id: 9925:INSM1
uniprot id: A0A452DNX0
names: Subcellular Location Annotation
messages: Nucleus

9925:FOLR2
gene id: 9925:FOLR2
uniprot id: A0A452EDH0
names: Similarity
messages: Belongs to the folate receptor family.

9925:PPM1A
gene id: 9925:PPM1A
uniprot id: A0A452FPD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PP2C family.
messages: Membrane
messages: cytosol

9925:CNIH4
gene id: 9925:CNIH4
uniprot id: A0A452ELL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cornichon family.
messages: Membrane

9925:ALDH3A1
gene id: 9925:ALDH3A1
uniprot id: A0A452G1D4
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9925:LOC102185863
gene id: 9925:LOC102185863
uniprot id: A0A452DU68
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:RUNX3
gene id: 9925:RUNX3
uniprot id: A0A452FY78
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus

9925:ACTN4
gene id: 9925:ACTN4
uniprot id: A0A452E7A9
uniprot id: A0A452E7B9
names: Similarity
messages: Belongs to the alpha-actinin family.

9925:LOC102179346
gene id: 9925:LOC102179346
uniprot id: A0A452FFW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COX15/CtaA family.
messages: Membrane

9925:PLAT
gene id: 9925:PLAT
uniprot id: A0A452DK58
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:SPNS2
gene id: 9925:SPNS2
uniprot id: A0A452G0V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
messages: Membrane

9925:LOC102172159
gene id: 9925:LOC102172159
uniprot id: A0A452ECF0
names: Similarity
messages: Belongs to the Bcl-2 family.

9925:NCK2
gene id: 9925:NCK2
uniprot id: A0A452E3L1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endoplasmic reticulum

9925:XKR9
gene id: 9925:XKR9
uniprot id: A0A452ES82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9925:IPO7
gene id: 9925:IPO7
uniprot id: A0A452FYG8
names: Subcellular Location Annotation
messages: Cytoplasm

9925:POLR2H
gene id: 9925:POLR2H
uniprot id: A0A452DSZ5
names: Function
names: Similarity
messages: Belongs to the eukaryotic RPB8 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.

9925:GSK3A
gene id: 9925:GSK3A
uniprot id: A0A452GAY2
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

9925:RIMKLB
gene id: 9925:RIMKLB
uniprot id: A0A452FQN4
names: Similarity
messages: Belongs to the RimK family.

9925:EMP3
gene id: 9925:EMP3
uniprot id: A0A452G6C6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Probably involved in cell proliferation and cell-cell interactions.

9925:LOC100861311
gene id: 9925:LOC100861311
uniprot id: A0A452DQK1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KRTAP type 6 family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9925:PDE3B
gene id: 9925:PDE3B
uniprot id: A0A452E0S6
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9925:DERL3
gene id: 9925:DERL3
uniprot id: A0A452EMW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9925:APOA4
gene id: 9925:APOA4
uniprot id: A0A452ED43
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9925:LOC102179500
gene id: 9925:LOC102179500
uniprot id: A0A452EE28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:NUDT19
gene id: 9925:NUDT19
uniprot id: A0A452FJL8
names: Similarity
messages: Belongs to the Nudix hydrolase family.

9925:ALDOB
gene id: 9925:ALDOB
uniprot id: A0A452DP89
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9925:TIE1
gene id: 9925:TIE1
uniprot id: A0A452EH46
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:EIF6
gene id: 9925:EIF6
uniprot id: A0A452E7Q2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-6 family.
messages: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.
messages: Cytoplasm
messages: Monomer. Associates with the 60S ribosomal subunit. Interacts with RACK1. Interacts with DICER1, AGO2, TARBP2, MOV10 and RPL7A; they form a large RNA-induced silencing complex (RISC).
messages: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
messages: nucleolus

9925:SYNM
gene id: 9925:SYNM
uniprot id: A0A452EWP1
names: Similarity
messages: Belongs to the intermediate filament family.

9925:TNNI3
gene id: 9925:TNNI3
uniprot id: I6V1W5
names: Function
names: Similarity
messages: Belongs to the troponin I family.
messages: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9925:ASNA1
gene id: 9925:ASNA1
uniprot id: A0A452FRM6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
messages: Belongs to the arsA ATPase family.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.
messages: nucleolus

9925:GALNT11
gene id: 9925:GALNT11
uniprot id: A0A452G8Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9925:HGD
gene id: 9925:HGD
uniprot id: A0A452G882
names: Similarity
messages: Belongs to the homogentisate dioxygenase family.

9925:FXR1
gene id: 9925:FXR1
uniprot id: A0A452EYY2
uniprot id: A0A452EZC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cytoplasmic ribonucleoprotein granule
messages: Nucleus envelope
messages: Postsynapse
messages: Synapse
messages: dendritic spine

9925:TMED6
gene id: 9925:TMED6
uniprot id: A0A452E4B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:PCOLCE2
gene id: 9925:PCOLCE2
uniprot id: A0A452FWZ7
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:GDF5
gene id: 9925:GDF5
uniprot id: A0A452ECY9
names: Similarity
messages: Belongs to the TGF-beta family.

9925:LOC102172245
gene id: 9925:LOC102172245
uniprot id: A0A452EHC0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.
messages: Cell membrane
messages: Interacts with LIN7C.
messages: Lateral cell membrane
messages: Membrane

9925:LOC102169830
gene id: 9925:LOC102169830
uniprot id: A0A452EAP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus
messages: nucleolus

9925:TIMM9
gene id: 9925:TIMM9
uniprot id: A0A452FDX5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9925:SERPINB1
gene id: 9925:SERPINB1
uniprot id: A0A452F5G1
names: Similarity
messages: Belongs to the serpin family.

9925:LOC102184254
gene id: 9925:LOC102184254
uniprot id: A0A452DNZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:VPS37D
gene id: 9925:VPS37D
uniprot id: A0A452E6S3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

9925:LOC102171395
gene id: 9925:LOC102171395
uniprot id: A0A452EER2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:REV1
gene id: 9925:REV1
uniprot id: A0A452EDA7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-Y family.
messages: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
messages: Nucleus

9925:HIGD1A
gene id: 9925:HIGD1A
uniprot id: A0A452EDX0
names: Subcellular Location Annotation
messages: Mitochondrion inner membrane

9925:DPAGT1
gene id: 9925:DPAGT1
uniprot id: A0A452EAI2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family.
messages: Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:SLC19A3
gene id: 9925:SLC19A3
uniprot id: A0A452EUE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Membrane

9925:MTERF3
gene id: 9925:MTERF3
uniprot id: A0A452E1T8
names: Similarity
messages: Belongs to the mTERF family.

9925:CSN3
gene id: 9925:CSN3
uniprot id: A0A858NBR7
uniprot id: P02670
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the kappa-casein family.
messages: Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
messages: Mammary gland specific. Secreted in milk.
messages: Secreted

9925:GJB2
gene id: 9925:GJB2
uniprot id: A0A452DQS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9925:TMEM167B
gene id: 9925:TMEM167B
uniprot id: A0A8C2XVM8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KISH family.
messages: Golgi apparatus membrane
messages: Involved in the early part of the secretory pathway.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:CALHM1
gene id: 9925:CALHM1
uniprot id: A0A452DLY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9925:LDH-A
gene id: 9925:LDH-A
uniprot id: D1MGL8
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9925:IL20
gene id: 9925:IL20
uniprot id: A0A452ECT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-10 family.
messages: Immune regulatory cytokine.
messages: Secreted

9925:CHMP1A
gene id: 9925:CHMP1A
uniprot id: A0A8C2R634
names: Similarity
messages: Belongs to the SNF7 family.

9925:LAMB3
gene id: 9925:LAMB3
uniprot id: A0A452DLU8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC108633249
gene id: 9925:LOC108633249
uniprot id: A0A452E2I7
names: Subcellular Location Annotation
messages: Mitochondrion

9925:AMIGO2
gene id: 9925:AMIGO2
uniprot id: A0A452EHY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Membrane

9925:POU4F1
gene id: 9925:POU4F1
uniprot id: A0A452DPR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9925:CRYBB3
gene id: 9925:CRYBB3
uniprot id: A0A452E101
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9925:TARS2
gene id: 9925:TARS2
uniprot id: A0A452F5U5
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9925:ITPRIPL2
gene id: 9925:ITPRIPL2
uniprot id: A0A452E2Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Membrane

9925:RFFL
gene id: 9925:RFFL
uniprot id: A0A452ECW9
names: Subcellular Location Annotation
messages: Cell membrane

9925:CHAT
gene id: 9925:CHAT
uniprot id: A0A452ES55
names: Similarity
messages: Belongs to the carnitine/choline acetyltransferase family.

9925:KAT5
gene id: 9925:KAT5
uniprot id: A0A452EQH7
uniprot id: A0A452EQJ5
uniprot id: A0A452EQT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MYST (SAS/MOZ) family.
messages: Nucleus

9925:NTSR2
gene id: 9925:NTSR2
uniprot id: A0A452EA07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:POLR3K
gene id: 9925:POLR3K
uniprot id: A0A452FDS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
messages: Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: nucleolus

9925:LOC108636023
gene id: 9925:LOC108636023
uniprot id: A0A452EWD7
names: Similarity
messages: Belongs to the apolipoprotein L family.

9925:PEX2
gene id: 9925:PEX2
uniprot id: A0A452E8P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pex2/pex10/pex12 family.
messages: Membrane
messages: Peroxisome membrane

9925:GNA12
gene id: 9925:GNA12
uniprot id: A0A452FX54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

9925:CUEDC2
gene id: 9925:CUEDC2
uniprot id: A0A452E651
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CUEDC2 family.
messages: Cytoplasm
messages: Nucleus

9925:LOC102183372
gene id: 9925:LOC102183372
uniprot id: A0A452ER57
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9925:DNM3
gene id: 9925:DNM3
uniprot id: A0A452E3I4
uniprot id: A0A452E3J1
uniprot id: A0A8C2RJJ0
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.

9925:SERPINI1
gene id: 9925:SERPINI1
uniprot id: A0A452DLZ5
names: Similarity
messages: Belongs to the serpin family.

9925:MFN1
gene id: 9925:MFN1
uniprot id: A0A452FI01
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9925:GRK7
gene id: 9925:GRK7
uniprot id: A0A452EAU4
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9925:SLC25A29
gene id: 9925:SLC25A29
uniprot id: A0A452EIB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:RPL10L
gene id: 9925:RPL10L
uniprot id: A0A452DPE5
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9925:CKMT2
gene id: 9925:CKMT2
uniprot id: A0A452F654
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9925:WARS2
gene id: 9925:WARS2
uniprot id: A0A452EGV3
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9925:ESYT3
gene id: 9925:ESYT3
uniprot id: A0A452ET03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:LOC102183619
gene id: 9925:LOC102183619
uniprot id: A0A452EB30
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ICAM1
gene id: 9925:ICAM1
uniprot id: A0A452ETY7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. ICAM family.
messages: Membrane

9925:ABCG4
gene id: 9925:ABCG4
uniprot id: A0A8C2R3J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9925:LOC102174291
gene id: 9925:LOC102174291
uniprot id: A0A452E6A2
names: Similarity
messages: Belongs to the serpin family.

9925:ENGASE
gene id: 9925:ENGASE
uniprot id: A0A452F5K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 85 family.
messages: cytosol

9925:KANSL2
gene id: 9925:KANSL2
uniprot id: A0A452G6A5
uniprot id: Q861R7
names: Function
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
messages: Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.
messages: Nucleus
messages: Ubiquitously expressed.

9925:AKIRIN1
gene id: 9925:AKIRIN1
uniprot id: A0A452ETW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the akirin family.
messages: Nucleus

9925:SDHAF1
gene id: 9925:SDHAF1
uniprot id: A0A452E4Z9
names: Similarity
messages: Belongs to the complex I LYR family. SDHAF1 subfamily.

9925:P3H2
gene id: 9925:P3H2
uniprot id: A0A452E7F1
names: Similarity
messages: Belongs to the leprecan family.

9925:SF3B4
gene id: 9925:SF3B4
uniprot id: A0A452G3X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3B4 family.
messages: Nucleus

9925:LOC102168875
gene id: 9925:LOC102168875
uniprot id: A0A452G6D7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

9925:RBM22
gene id: 9925:RBM22
uniprot id: A0A452ESB3
names: Similarity
messages: Belongs to the SLT11 family.

9925:FKRP
gene id: 9925:FKRP
uniprot id: A0A452DRM9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LicD transferase family.
messages: Golgi apparatus membrane

9925:TBX2
gene id: 9925:TBX2
uniprot id: A0A452ELH5
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9925:ABCC9
gene id: 9925:ABCC9
uniprot id: A0A452G8L7
uniprot id: A0A452G8M6
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with KCNJ11.
messages: Membrane

9925:POLR2J
gene id: 9925:POLR2J
uniprot id: A0A452DYC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.
messages: Nucleus

9925:DCAF11
gene id: 9925:DCAF11
uniprot id: A0A452EWY7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat LEC14B family.
messages: Interacts with DDB1 and CUL4A.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

9925:RAB32
gene id: 9925:RAB32
uniprot id: A0A452EKZ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Membrane
messages: The small GTPases Rab are key regulators in vesicle trafficking.

9925:ADCY3
gene id: 9925:ADCY3
uniprot id: A0A452G4N4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9925:DSC3
gene id: 9925:DSC3
uniprot id: A0A452FKJ7
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9925:RHBDF2
gene id: 9925:RHBDF2
uniprot id: A0A452FZP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.

9925:MARVELD1
gene id: 9925:MARVELD1
uniprot id: A0A452F918
names: Subcellular Location Annotation
messages: Membrane

9925:CAT
gene id: 9925:CAT
uniprot id: A0A452FHI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the catalase family.
messages: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
messages: Peroxisome

9925:MTFP1
gene id: 9925:MTFP1
uniprot id: A0A452EEB6
names: Similarity
messages: Belongs to the MTFP1 family.

9925:MIF
gene id: 9925:MIF
uniprot id: A0A452FQK5
names: Similarity
messages: Belongs to the MIF family.

9925:ADCK5
gene id: 9925:ADCK5
uniprot id: A0A8C2RPP6
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9925:RAB21
gene id: 9925:RAB21
uniprot id: A0A452DQS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cleavage furrow
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: trans-Golgi network

9925:SUCLA2
gene id: 9925:SUCLA2
uniprot id: A0A452F6E5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
messages: Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.
messages: Mitochondrion

9925:XKR5
gene id: 9925:XKR5
uniprot id: A0A452F4Q4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9925:DPYS
gene id: 9925:DPYS
uniprot id: A0A452G247
names: PTM
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
messages: Carbamylation allows a single lysine to coordinate two divalent metal cations.

9925:LECT2
gene id: 9925:LECT2
uniprot id: A0A452FCJ1
names: Similarity
messages: Belongs to the LECT2/MIM-1 family.

9925:ST8SIA4
gene id: 9925:ST8SIA4
uniprot id: A0A452DMZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9925:PDRG1
gene id: 9925:PDRG1
uniprot id: A0A452EWR8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.
messages: Cytoplasm
messages: May play a role in chaperone-mediated protein folding.

9925:SNPH
gene id: 9925:SNPH
uniprot id: A0A8C2P8G0
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102174956
gene id: 9925:LOC102174956
uniprot id: A0A452E544
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ZSCAN29
gene id: 9925:ZSCAN29
uniprot id: A0A452FH27
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9925:NPR2
gene id: 9925:NPR2
uniprot id: A0A452DYK0
uniprot id: H2ET88
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9925:UGP2
gene id: 9925:UGP2
uniprot id: A0A8C2NUG4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UDPGP type 1 family.
messages: Homooctamer.
messages: UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen.

9925:ERRFI1
gene id: 9925:ERRFI1
uniprot id: A0A452EJ48
names: Subcellular Location Annotation
messages: Membrane
messages: Nucleus

9925:CA6
gene id: 9925:CA6
uniprot id: A0A452DMT4
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9925:IL1R1
gene id: 9925:IL1R1
uniprot id: A0A452EED2
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9925:FOXB2
gene id: 9925:FOXB2
uniprot id: A0A452DQM9
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102172954
gene id: 9925:LOC102172954
uniprot id: A0A452DWU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:CDC42EP5
gene id: 9925:CDC42EP5
uniprot id: A0A452E738
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BORG/CEP family.
messages: Endomembrane system

9925:FRZB
gene id: 9925:FRZB
uniprot id: A0A452FJK9
names: Caution
names: Function
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.

9925:NECAP1
gene id: 9925:NECAP1
uniprot id: A0A452EAL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NECAP family.
messages: Involved in endocytosis.
messages: clathrin-coated vesicle membrane

9925:SPRN
gene id: 9925:SPRN
uniprot id: C6ESG8
names: Function
names: Similarity
messages: Belongs to the SPRN family.
messages: Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP.

9925:ERCC2
gene id: 9925:ERCC2
uniprot id: A0A452FRN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RAD3/XPD subfamily.
messages: Nucleus

9925:ID3
gene id: 9925:ID3
uniprot id: A0A452FYD9
names: Subcellular Location Annotation
messages: Nucleus

9925:SNX9
gene id: 9925:SNX9
uniprot id: A0A452EIJ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Cytoplasmic vesicle membrane

9925:LOC102186232
gene id: 9925:LOC102186232
uniprot id: A0A8C2PH31
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LSM4
gene id: 9925:LSM4
uniprot id: A0A8C2QTK8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus

9925:PELP1
gene id: 9925:PELP1
uniprot id: A0A452G925
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RIX1/PELP1 family.
messages: Cytoplasm
messages: Nucleus

9925:MPI
gene id: 9925:MPI
uniprot id: A0A452EA58
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 1 family.
messages: Binds 1 zinc ion per subunit.
messages: Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

9925:SNAP25
gene id: 9925:SNAP25
uniprot id: A0A452FD97
uniprot id: A0A452FDT8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNAP-25 family.
messages: Cell membrane
messages: Membrane
messages: Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.
messages: Photoreceptor inner segment
messages: synaptosome
messages: t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.

9925:PDE6G
gene id: 9925:PDE6G
uniprot id: A0A452EUI3
names: Function
names: Similarity
messages: Belongs to the rod/cone cGMP-PDE gamma subunit family.
messages: Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.

9925:OIP5
gene id: 9925:OIP5
uniprot id: A0A452G5Q1
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
messages: centromere

9925:DCTPP1
gene id: 9925:DCTPP1
uniprot id: A0A452DXU3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homotetramer.
messages: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.
messages: cytosol

9925:LOC100861381
gene id: 9925:LOC100861381
uniprot id: Q6R651
names: Similarity
messages: Belongs to the intermediate filament family.

9925:BMP4
gene id: 9925:BMP4
uniprot id: A0A2Z4FRB3
uniprot id: A6N998
names: Similarity
messages: Belongs to the TGF-beta family.

9925:NOTCH2
gene id: 9925:NOTCH2
uniprot id: A0A452FP76
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOTCH family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Nucleus

9925:C15H11orf49
gene id: 9925:C15H11orf49
uniprot id: A0A8C2S581
uniprot id: A0A8C2Y1D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSTPP1 family.
messages: cytoskeleton

9925:GDF11
gene id: 9925:GDF11
uniprot id: A0A452DM24
names: Similarity
messages: Belongs to the TGF-beta family.

9925:SFRP4
gene id: 9925:SFRP4
uniprot id: A0A452DXL5
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:RARS2
gene id: 9925:RARS2
uniprot id: A0A452EAA9
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9925:TNFAIP2
gene id: 9925:TNFAIP2
uniprot id: A0A452DSY3
names: Similarity
messages: Belongs to the SEC6 family.

9925:TMEM186
gene id: 9925:TMEM186
uniprot id: A0A8C2R2U9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM186 family.
messages: Membrane

9925:MRPS21
gene id: 9925:MRPS21
uniprot id: A0A452FIR3
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

9925:SLC30A10
gene id: 9925:SLC30A10
uniprot id: A0A452FP64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9925:MRPL4
gene id: 9925:MRPL4
uniprot id: A0A452DLY1
names: Similarity
messages: Belongs to the universal ribosomal protein uL4 family.

9925:SIVA1
gene id: 9925:SIVA1
uniprot id: A0A452FIV7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
messages: Nucleus

9925:BMPR1B
gene id: 9925:BMPR1B
uniprot id: A0A452F241
uniprot id: A0A452F2E9
uniprot id: B5AFX6
uniprot id: Q4PRC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9925:VPS41
gene id: 9925:VPS41
uniprot id: A0A452DST1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS41 family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.
messages: Vesicle
messages: clathrin-coated vesicle
messages: trans-Golgi network

9925:CMKLR1
gene id: 9925:CMKLR1
uniprot id: A0A452E3R0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Membrane

9925:CRABP1
gene id: 9925:CRABP1
uniprot id: A0A452F8E2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9925:RAD52
gene id: 9925:RAD52
uniprot id: A0A452DYL1
names: Similarity
messages: Belongs to the RAD52 family.

9925:ORMDL2
gene id: 9925:ORMDL2
uniprot id: A0A452F5J6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9925:LMOD1
gene id: 9925:LMOD1
uniprot id: A0A452DU46
names: Subcellular Location Annotation
messages: cytoskeleton
messages: sarcomere

9925:LOC102169288
gene id: 9925:LOC102169288
uniprot id: A0A452E7P3
names: Similarity
messages: Belongs to the HPF1 family.

9925:TEFM
gene id: 9925:TEFM
uniprot id: A0A452FZ70
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TEFM family.
messages: Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.
messages: mitochondrion nucleoid

9925:SPTAN1
gene id: 9925:SPTAN1
uniprot id: A0A452EHE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spectrin family.
messages: cell cortex
messages: cytoskeleton

9925:ZFYVE9
gene id: 9925:ZFYVE9
uniprot id: A0A452GAR7
uniprot id: A0A452GB02
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane

9925:EXO1
gene id: 9925:EXO1
uniprot id: A0A452EF10
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.
messages: Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Nucleus

9925:SLC35B3
gene id: 9925:SLC35B3
uniprot id: A0A452F3S4
uniprot id: A0A452F415
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9925:SIDT1
gene id: 9925:SIDT1
uniprot id: A0A452EW95
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SID1 family.
messages: Membrane

9925:ABHD3
gene id: 9925:ABHD3
uniprot id: A0A452FYY9
names: Similarity
messages: Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

9925:PSMC2
gene id: 9925:PSMC2
uniprot id: A0A452ER37
names: Similarity
messages: Belongs to the AAA ATPase family.

9925:CA4
gene id: 9925:CA4
uniprot id: A0A452G7Y5
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.

9925:PLCG1
gene id: 9925:PLCG1
uniprot id: A0A452FZI4
names: Function
messages: Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.

9925:PITX2
gene id: 9925:PITX2
uniprot id: A0A0H3XRN2
uniprot id: A0A452E417
uniprot id: A0A452E421
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9925:PRCP
gene id: 9925:PRCP
uniprot id: A0A452E754
names: Similarity
messages: Belongs to the peptidase S28 family.

9925:HSP90AB1
gene id: 9925:HSP90AB1
uniprot id: A0A452F327
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

9925:RFTN2
gene id: 9925:RFTN2
uniprot id: A0A452EDW7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the raftlin family.
messages: Cell membrane
messages: Membrane

9925:RARA
gene id: 9925:RARA
uniprot id: A0A452EMU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Nucleus

9925:C3AR1
gene id: 9925:C3AR1
uniprot id: A0A452DUR2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Belongs to the chemokine-like receptor (CMKLR) family.
messages: Cell membrane
messages: Interacts with VGF-derived peptide TLQP-21.
messages: Membrane
messages: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.

9925:TRMT112
gene id: 9925:TRMT112
uniprot id: A0A452FVR4
names: Similarity
messages: Belongs to the TRM112 family.

9925:HAGH
gene id: 9925:HAGH
uniprot id: A0A452FQ64
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9925:NDUFB2
gene id: 9925:NDUFB2
uniprot id: A0A452EXX4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB2 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9925:ELOVL2
gene id: 9925:ELOVL2
uniprot id: A0A452DNY4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL2 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9925:TOR1A
gene id: 9925:TOR1A
uniprot id: A0A452FDT1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.
messages: Endoplasmic reticulum lumen

9925:HCRTR1
gene id: 9925:HCRTR1
uniprot id: A0A452E7T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:UBA5
gene id: 9925:UBA5
uniprot id: A0A452FIL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus

9925:PIGV
gene id: 9925:PIGV
uniprot id: A0A452FYH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGV family.
messages: Endoplasmic reticulum membrane
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.
messages: Membrane

9925:PRIMPOL
gene id: 9925:PRIMPOL
uniprot id: A0A452EUL5
names: Similarity
messages: Belongs to the eukaryotic-type primase small subunit family.

9925:LOC102180594
gene id: 9925:LOC102180594
uniprot id: A0A452DZ01
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

9925:LOC102186759
gene id: 9925:LOC102186759
uniprot id: A0A452G8F3
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:AKT2
gene id: 9925:AKT2
uniprot id: A0A452EQ89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
messages: Cytoplasm

9925:GADD45G
gene id: 9925:GADD45G
uniprot id: A0A452EWC6
names: Similarity
messages: Belongs to the GADD45 family.

9925:SENP7
gene id: 9925:SENP7
uniprot id: A0A452DV21
names: Similarity
messages: Belongs to the peptidase C48 family.

9925:LOC102181154
gene id: 9925:LOC102181154
uniprot id: A0A452EYB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9925:FAM126B
gene id: 9925:FAM126B
uniprot id: A0A452EVM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Hyccin family.
messages: Cell membrane
messages: Membrane
messages: cytosol

9925:SPTY2D1
gene id: 9925:SPTY2D1
uniprot id: A0A452FCP3
names: Similarity
messages: Belongs to the SPT2 family.

9925:AIM1
gene id: 9925:AIM1
uniprot id: A0A452FFP3
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9925:STK17B
gene id: 9925:STK17B
uniprot id: A0A452EIV5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:SOD2
gene id: 9925:SOD2
uniprot id: A0A452E294
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
messages: Homotetramer.
messages: Mitochondrion matrix

9925:CPPED1
gene id: 9925:CPPED1
uniprot id: A0A452F948
names: Function
names: Similarity
messages: Belongs to the metallophosphoesterase superfamily. CPPED1 family.
messages: Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.

9925:LOC108634229
gene id: 9925:LOC108634229
uniprot id: A0A452EUD2
names: Similarity
messages: Belongs to the peptidase A1 family.

9925:LOC102180215
gene id: 9925:LOC102180215
uniprot id: A0A452E9V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM8 family.
messages: Membrane

9925:LOC102169980
gene id: 9925:LOC102169980
uniprot id: A0A452DYT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:NDUFA11
gene id: 9925:NDUFA11
uniprot id: A0A452FHJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA11 subunit family.
messages: Mitochondrion inner membrane

9925:ZFPM1
gene id: 9925:ZFPM1
uniprot id: A0A452E2Z5
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC108636628
gene id: 9925:LOC108636628
uniprot id: A0A452E0W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:HPDL
gene id: 9925:HPDL
uniprot id: A0A452E319
names: Similarity
messages: Belongs to the 4HPPD family.

9925:LOC102185494
gene id: 9925:LOC102185494
uniprot id: A0A452EXJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNF-like-inhibitor family.
messages: Secreted

9925:LOC108637118
gene id: 9925:LOC108637118
uniprot id: A0A452E2N3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:KEF96 p05
gene id: 9925:KEF96_p05
uniprot id: Q7YBC1
uniprot id: S6ASB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
messages: Membrane
messages: Mitochondrion inner membrane

9925:UCK1
gene id: 9925:UCK1
uniprot id: A0A452E6I6
names: Similarity
messages: Belongs to the uridine kinase family.

9925:SEC24A
gene id: 9925:SEC24A
uniprot id: A0A452G0M5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
messages: COPII-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9925:PRKD2
gene id: 9925:PRKD2
uniprot id: A0A452FHM6
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

9925:TINAG
gene id: 9925:TINAG
uniprot id: A0A452E5Y6
names: Similarity
messages: Belongs to the peptidase C1 family.

9925:LTA4H
gene id: 9925:LTA4H
uniprot id: A0A452F0G8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm

9925:LOC102176290
gene id: 9925:LOC102176290
uniprot id: A0A452EIU9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UQCRH/QCR6 family.
messages: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Mitochondrion inner membrane

9925:STIM1
gene id: 9925:STIM1
uniprot id: A0A452F0Z6
uniprot id: A0A452F137
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:ROMO1
gene id: 9925:ROMO1
uniprot id: A0A452E3J5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGR2 family.
messages: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
messages: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.
messages: Mitochondrion inner membrane

9925:RBCK1
gene id: 9925:RBCK1
uniprot id: A0A452G7S2
names: Similarity
messages: Belongs to the RBR family.

9925:SMAD6
gene id: 9925:SMAD6
uniprot id: A0A452ECS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9925:LOC102187653
gene id: 9925:LOC102187653
uniprot id: A0A452DPZ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:RXRB
gene id: 9925:RXRB
uniprot id: A0A452E335
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

9925:GALNT10
gene id: 9925:GALNT10
uniprot id: A0A452EYJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9925:ABCC5
gene id: 9925:ABCC5
uniprot id: A0A452FXQ4
names: Subcellular Location Annotation
messages: Membrane

9925:CUL3
gene id: 9925:CUL3
uniprot id: A0A452DVZ8
names: Similarity
messages: Belongs to the cullin family.

9925:SLC25A17
gene id: 9925:SLC25A17
uniprot id: A0A8C2NYZ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:PLD5
gene id: 9925:PLD5
uniprot id: A0A452F1V1
names: Similarity
messages: Belongs to the phospholipase D family.

9925:CDH2
gene id: 9925:CDH2
uniprot id: A0A452F6C4
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9925:AASS
gene id: 9925:AASS
uniprot id: A0A452E108
names: Similarity
messages: In the C-terminal section; belongs to the saccharopine dehydrogenase family.
messages: In the N-terminal section; belongs to the AlaDH/PNT family.

9925:SLC33A1
gene id: 9925:SLC33A1
uniprot id: A0A452EHX5
names: Subcellular Location Annotation
messages: Membrane

9925:TMEM30A
gene id: 9925:TMEM30A
uniprot id: A0A452FS07
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

9925:CAPN7
gene id: 9925:CAPN7
uniprot id: A0A452FN84
names: Similarity
messages: Belongs to the peptidase C2 family.

9925:RBM42
gene id: 9925:RBM42
uniprot id: A0A452E0C8
uniprot id: A0A452E0I3
names: Similarity
messages: Belongs to the RRM RBM42 family.

9925:CNNM4
gene id: 9925:CNNM4
uniprot id: A0A452EIC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: Membrane
messages: Metal transporter.

9925:CD74
gene id: 9925:CD74
uniprot id: A0A8C2N5H2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:BVES
gene id: 9925:BVES
uniprot id: A0A452DWR8
names: Similarity
messages: Belongs to the popeye family.

9925:SLC2A4
gene id: 9925:SLC2A4
uniprot id: I0BWM0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Endomembrane system
messages: Membrane
messages: perinuclear region

9925:LDHB
gene id: 9925:LDHB
uniprot id: A0A452E480
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9925:TMOD2
gene id: 9925:TMOD2
uniprot id: A0A452FSM2
names: Subcellular Location Annotation
messages: cytoskeleton

9925:TSHZ3
gene id: 9925:TSHZ3
uniprot id: A0A452ENH8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.
messages: Nucleus

9925:MMP23B
gene id: 9925:MMP23B
uniprot id: A0A452G094
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:PTGS1
gene id: 9925:PTGS1
uniprot id: A0A452DMH9
names: Caution
names: Similarity
messages: Belongs to the prostaglandin G/H synthase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102177414
gene id: 9925:LOC102177414
uniprot id: A0A452E3P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM198 family.
messages: Membrane

9925:NOVA1
gene id: 9925:NOVA1
uniprot id: A0A452F715
uniprot id: A0A452F764
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with PTBP2; the interaction is direct.
messages: Nucleus

9925:SEMA6A
gene id: 9925:SEMA6A
uniprot id: A0A452F3A0
uniprot id: A0A452F3F7
uniprot id: A0A452F3L7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102175436
gene id: 9925:LOC102175436
uniprot id: A0A452EE56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9925:SND1
gene id: 9925:SND1
uniprot id: A0A452FU71
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.

9925:HABP2
gene id: 9925:HABP2
uniprot id: A0A452FA32
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:FYTTD1
gene id: 9925:FYTTD1
uniprot id: A0A452FHL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UIF family.
messages: Nucleus speckle
messages: nucleoplasm

9925:TFPI2
gene id: 9925:TFPI2
uniprot id: A0A452G9D6
names: Subcellular Location Annotation
messages: Secreted

9925:OSGEP
gene id: 9925:OSGEP
uniprot id: A0A8C2RNZ7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleus

9925:LOC108633453
gene id: 9925:LOC108633453
uniprot id: A0A452DNW0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102182894
gene id: 9925:LOC102182894
uniprot id: A0A452G8V4
names: Similarity
messages: Belongs to the globin family.

9925:NOL8
gene id: 9925:NOL8
uniprot id: A0A452FV23
names: Subcellular Location Annotation
messages: nucleolus

9925:PRKACB
gene id: 9925:PRKACB
uniprot id: A0A452FXJ7
uniprot id: A0A452FXT1
uniprot id: A0A452FYA4
uniprot id: A0A452FYK9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
messages: Nucleus

9925:LOC102185107
gene id: 9925:LOC102185107
uniprot id: A0A452DQG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:IYD
gene id: 9925:IYD
uniprot id: A0A452G9S6
names: Subcellular Location Annotation
messages: Cell membrane

9925:DIEXF
gene id: 9925:DIEXF
uniprot id: A0A452FK85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP25 family.
messages: nucleolus

9925:HGS
gene id: 9925:HGS
uniprot id: A0A452G1F4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.
messages: multivesicular body membrane

9925:ASUN
gene id: 9925:ASUN
uniprot id: A0A452DNR2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the asunder family.
messages: Cytoplasm
messages: Nucleus

9925:PHC2
gene id: 9925:PHC2
uniprot id: A0A8C2NFZ3
names: Subcellular Location Annotation
messages: Nucleus

9925:TRIM21
gene id: 9925:TRIM21
uniprot id: A0A452FZ00
names: Subcellular Location Annotation
messages: Cytoplasm

9925:CPT1C
gene id: 9925:CPT1C
uniprot id: A0A8C2RVY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the carnitine/choline acetyltransferase family.
messages: Membrane
messages: Mitochondrion outer membrane

9925:ADGRG6
gene id: 9925:ADGRG6
uniprot id: A0A452FPG4
uniprot id: A0A452FPI1
uniprot id: A0A452FPJ3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:ALOX12B
gene id: 9925:ALOX12B
uniprot id: A0A452FQN7
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:GCFC2
gene id: 9925:GCFC2
uniprot id: A0A452ETN1
names: Similarity
messages: Belongs to the GCF family.

9925:ECHS1
gene id: 9925:ECHS1
uniprot id: A0A452DLQ9
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9925:DGKB
gene id: 9925:DGKB
uniprot id: A0A452FGG3
uniprot id: A0A452FGK8
uniprot id: A0A452FH45
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9925:N4BP3
gene id: 9925:N4BP3
uniprot id: A0A452G5P8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the N4BP3 family.
messages: Vesicle
messages: dendrite

9925:AP1B1
gene id: 9925:AP1B1
uniprot id: A0A452FHH1
uniprot id: A0A452FHM1
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9925:UNC5B
gene id: 9925:UNC5B
uniprot id: A0A452ECC3
uniprot id: A0A452ECQ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-5 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding.

9925:SGF29
gene id: 9925:SGF29
uniprot id: A0A452EQP6
names: Subcellular Location Annotation
messages: Nucleus

9925:FZD6
gene id: 9925:FZD6
uniprot id: A0A452EZ62
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:RPS3A
gene id: 9925:RPS3A
uniprot id: A0A452EVI7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus
messages: nucleolus

9925:NSMCE4A
gene id: 9925:NSMCE4A
uniprot id: A0A452ENN7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE4 family.
messages: Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.
messages: Component of the SMC5-SMC6 complex.
messages: Nucleus
messages: telomere

9925:FGF20
gene id: 9925:FGF20
uniprot id: A0A452EP49
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9925:LOC102189373
gene id: 9925:LOC102189373
uniprot id: A0A452FCP7
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9925:SLC37A2
gene id: 9925:SLC37A2
uniprot id: A0A452EG79
uniprot id: A0A452EGL9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.
messages: Membrane

9925:DUS3L
gene id: 9925:DUS3L
uniprot id: A0A452FHK9
names: Similarity
messages: Belongs to the dus family. Dus3 subfamily.

9925:CDH8
gene id: 9925:CDH8
uniprot id: A0A452F432
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9925:LOC102184252
gene id: 9925:LOC102184252
uniprot id: A0A452EC23
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:C15H11orf87
gene id: 9925:C15H11orf87
uniprot id: A0A452E366
names: Subcellular Location Annotation
messages: Membrane

9925:MEX3D
gene id: 9925:MEX3D
uniprot id: A0A452EEE1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:ADCK1
gene id: 9925:ADCK1
uniprot id: A0A452G7Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.
messages: Secreted

9925:ELP2
gene id: 9925:ELP2
uniprot id: A0A452EW80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat ELP2 family.
messages: Cytoplasm
messages: Nucleus

9925:KDR
gene id: 9925:KDR
uniprot id: A0A452DTK5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9925:ZNF532
gene id: 9925:ZNF532
uniprot id: A0A452E025
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9925:REXO4
gene id: 9925:REXO4
uniprot id: A0A452DZR9
names: Similarity
messages: Belongs to the REXO4 family.

9925:TROVE2
gene id: 9925:TROVE2
uniprot id: A0A452F4E3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Ro 60 kDa family.
messages: Cytoplasm

9925:MAPK9
gene id: 9925:MAPK9
uniprot id: A0A452EJ55
uniprot id: A0A452EJ75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Cytoplasm
messages: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

9925:LOC108633784
gene id: 9925:LOC108633784
uniprot id: A0A452DTU8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
messages: Secreted

9925:FGG
gene id: 9925:FGG
uniprot id: A0A452EM67
uniprot id: A0A452EN73
names: Subcellular Location Annotation
names: Subunit
messages: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
messages: Secreted

9925:ATP5O
gene id: 9925:ATP5O
uniprot id: A0A8C2NCS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion inner membrane

9925:LOC102173384
gene id: 9925:LOC102173384
uniprot id: A0A059U1E3
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9925:C7H5orf63
gene id: 9925:C7H5orf63
uniprot id: A0A452FT28
names: Similarity
messages: Belongs to the glutaredoxin family.

9925:FGD3
gene id: 9925:FGD3
uniprot id: A0A452DZK2
uniprot id: A0A452DZL3
names: Subcellular Location Annotation
messages: cytoskeleton

9925:CDK20
gene id: 9925:CDK20
uniprot id: A0A452EEB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
messages: cilium

9925:LOC102186788
gene id: 9925:LOC102186788
uniprot id: A0A452DX47
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ACADL
gene id: 9925:ACADL
uniprot id: A0A452ED25
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acyl-CoA dehydrogenase family.
messages: Homotetramer.
messages: Mitochondrion matrix

9925:MEX3A
gene id: 9925:MEX3A
uniprot id: A0A452EDX4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:GUF1
gene id: 9925:GUF1
uniprot id: A0A452E339
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding elongation factor family. LepA subfamily.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Mitochondrion inner membrane
messages: Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.

9925:PRPF3
gene id: 9925:PRPF3
uniprot id: A0A452ERP9
uniprot id: A0A8C2N6A3
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex).

9925:TOMM22
gene id: 9925:TOMM22
uniprot id: A0A8C2SIR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom22 family.
messages: Mitochondrion outer membrane

9925:HMOX1
gene id: 9925:HMOX1
uniprot id: F6M7A9
names: Similarity
messages: Belongs to the heme oxygenase family.

9925:MATK
gene id: 9925:MATK
uniprot id: A0A452ELJ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9925:GNA11
gene id: 9925:GNA11
uniprot id: A0A452EAS1
names: Similarity
messages: Belongs to the G-alpha family. G(q) subfamily.

9925:C7H5orf24
gene id: 9925:C7H5orf24
uniprot id: A0A452EAX5
names: Similarity
messages: Belongs to the UPF0461 family.

9925:DRD5
gene id: 9925:DRD5
uniprot id: A0A452DWQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:XRCC3
gene id: 9925:XRCC3
uniprot id: A0A452FG83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Cytoplasm
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.
messages: Nucleus

9925:TNFRSF6B
gene id: 9925:TNFRSF6B
uniprot id: A0A452FVT9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:SLF2
gene id: 9925:SLF2
uniprot id: A0A452FGI2
names: Similarity
messages: Belongs to the FAM178 family.

9925:RAB3C
gene id: 9925:RAB3C
uniprot id: A0A452DLV5
uniprot id: A0A452DLV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9925:IRX1
gene id: 9925:IRX1
uniprot id: A0A452F2J9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9925:MELK
gene id: 9925:MELK
uniprot id: A0A452G6D5
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9925:AMACR
gene id: 9925:AMACR
uniprot id: A0A452E8V4
names: Similarity
messages: Belongs to the CoA-transferase III family.

9925:PAEP
gene id: 9925:PAEP
uniprot id: P02756
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Alternate disulfide bonds occur in equal amounts.
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
messages: Secreted
messages: Synthesized in mammary gland and secreted in milk.
messages: Under physiological conditions beta-lactoglobulin exists as an equilibrium mixture of monomeric and dimeric forms (By similarity). Interaction with LMBR1L is controversial (By similarity).

9925:PPP5C
gene id: 9925:PPP5C
uniprot id: A0A452FYS8
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.

9925:C3H1orf123
gene id: 9925:C3H1orf123
uniprot id: A0A8C2NRE8
names: Similarity
messages: Belongs to the UPF0587 family.

9925:LOC102191477
gene id: 9925:LOC102191477
uniprot id: A0A452E2P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:NPEPPS
gene id: 9925:NPEPPS
uniprot id: A0A452FQK2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Membrane

9925:RNASEH1
gene id: 9925:RNASEH1
uniprot id: A0A452FM14
names: Function
names: Similarity
messages: Belongs to the RNase H family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

9925:IFNG
gene id: 9925:IFNG
uniprot id: P79154
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the type II (or gamma) interferon family.
messages: Homodimer. Interacts with IFNGR1 (via extracellular domain); this interaction promotes IFNGR1 dimerization.
messages: Released primarily from activated T lymphocytes.
messages: Secreted
messages: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).

9925:LOC102181181
gene id: 9925:LOC102181181
uniprot id: A0A452F8B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

9925:LOC102168522
gene id: 9925:LOC102168522
uniprot id: A0A452FFU2
uniprot id: A0A8C2RB45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9925:SLC12A6
gene id: 9925:SLC12A6
uniprot id: A0A452E6L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9925:SLC25A38
gene id: 9925:SLC25A38
uniprot id: A0A452FQZ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.
messages: Membrane
messages: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.
messages: Mitochondrion inner membrane
messages: Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis.

9925:ERCC1
gene id: 9925:ERCC1
uniprot id: A0A452G3Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERCC1/RAD10/SWI10 family.
messages: Nucleus

9925:THAP1
gene id: 9925:THAP1
uniprot id: A0A452EC21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the THAP1 family.
messages: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.
messages: Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.
messages: nucleoplasm

9925:PLA2G15
gene id: 9925:PLA2G15
uniprot id: A0A452DYD0
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9925:SYK
gene id: 9925:SYK
uniprot id: A0A452EBK3
uniprot id: A0A452EBP4
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.

9925:APOE
gene id: 9925:APOE
uniprot id: A0A452FL25
names: Similarity
messages: Belongs to the apolipoprotein A1/A4/E family.

9925:STARD6
gene id: 9925:STARD6
uniprot id: A0A452ESH0
names: Function
messages: May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols.

9925:RHBG
gene id: 9925:RHBG
uniprot id: A0A452F626
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
messages: Membrane

9925:ZC3H12C
gene id: 9925:ZC3H12C
uniprot id: A0A452FH34
names: Similarity
messages: Belongs to the ZC3H12 family.

9925:ANTXR2
gene id: 9925:ANTXR2
uniprot id: A0A452EEY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATR family.
messages: Membrane

9925:PCSK1
gene id: 9925:PCSK1
uniprot id: A0A452E007
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S8 family.
messages: Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
messages: Vesicle
messages: secretory vesicle

9925:MGAT5
gene id: 9925:MGAT5
uniprot id: A0A452GBB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 18 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Secreted

9925:INSIG2
gene id: 9925:INSIG2
uniprot id: G1DGF2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9925:NTMT1
gene id: 9925:NTMT1
uniprot id: A0A452DYM0
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

9925:LOC102184740
gene id: 9925:LOC102184740
uniprot id: A0A452E0P6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TMEM131
gene id: 9925:TMEM131
uniprot id: A0A452FX59
names: Similarity
messages: Belongs to the TMEM131 family.

9925:DUS4L
gene id: 9925:DUS4L
uniprot id: A0A452E5V1
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.

9925:MRGBP
gene id: 9925:MRGBP
uniprot id: A0A452EMF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EAF7 family.
messages: Nucleus

9925:LOC102179033
gene id: 9925:LOC102179033
uniprot id: A0A452DW41
names: Similarity
messages: Belongs to the PRAME family.

9925:RAP2B
gene id: 9925:RAP2B
uniprot id: A0A452E9E7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ras family.
messages: Endosome membrane
messages: Palmitoylated.
messages: Recycling endosome membrane
messages: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form.

9925:IL33
gene id: 9925:IL33
uniprot id: A0A452FD34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family. Highly divergent.
messages: Chromosome
messages: Nucleus
messages: Secreted
messages: Vesicle
messages: secretory vesicle

9925:STAT2
gene id: 9925:STAT2
uniprot id: A0A452ET77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9925:DDI1
gene id: 9925:DDI1
uniprot id: A0A8C2XXW0
names: Similarity
messages: Belongs to the DDI1 family.

9925:TMEM38A
gene id: 9925:TMEM38A
uniprot id: A0A452FVZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM38 family.
messages: Membrane
messages: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.

9925:RFT1
gene id: 9925:RFT1
uniprot id: A0A452EQ74
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RFT1 family.
messages: May be involved in N-linked oligosaccharide assembly.
messages: Membrane

9925:ARL5C
gene id: 9925:ARL5C
uniprot id: A0A452DW46
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9925:PDE4A
gene id: 9925:PDE4A
uniprot id: A0A452FD65
uniprot id: A0A8C2NK15
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9925:GABBR1
gene id: 9925:GABBR1
uniprot id: A0A452EI80
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:ARRDC1
gene id: 9925:ARRDC1
uniprot id: A0A452G3H1
names: Similarity
messages: Belongs to the arrestin family.

9925:LOC102174506
gene id: 9925:LOC102174506
uniprot id: A0A452FSB1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IGFL family.
messages: Secreted

9925:IFI6
gene id: 9925:IFI6
uniprot id: A0A452F2E5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFI6/IFI27 family.
messages: Membrane

9925:KDM4C
gene id: 9925:KDM4C
uniprot id: A0A452G806
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM3 histone demethylase family.
messages: Nucleus

9925:LOC102184368
gene id: 9925:LOC102184368
uniprot id: A0A452E2X0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:NDUFS7
gene id: 9925:NDUFS7
uniprot id: A0A452DXI1
uniprot id: A0A8C2R9J1
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

9925:PPARGC1B
gene id: 9925:PPARGC1B
uniprot id: A0A452DQD6
names: Subcellular Location Annotation
messages: Nucleus

9925:BRINP2
gene id: 9925:BRINP2
uniprot id: A0A452ELS2
names: Similarity
messages: Belongs to the BRINP family.

9925:COPG2
gene id: 9925:COPG2
uniprot id: A0A452E3J9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COPG family.
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.

9925:TMEM57
gene id: 9925:TMEM57
uniprot id: A0A452G9G8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the macoilin family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus membrane
messages: Plays a role in the regulation of neuronal activity.
messages: Rough endoplasmic reticulum membrane

9925:LOC102169149
gene id: 9925:LOC102169149
uniprot id: A0A452EDZ4
names: Similarity
messages: Belongs to the S-100 family.

9925:LOC102177035
gene id: 9925:LOC102177035
uniprot id: A0A452EC02
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:EDNRA
gene id: 9925:EDNRA
uniprot id: A0A452FAQ5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with HDAC7 and KAT5.
messages: Membrane
messages: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

9925:CHDH
gene id: 9925:CHDH
uniprot id: A0A452E2A6
names: Similarity
messages: Belongs to the GMC oxidoreductase family.

9925:RCAN1
gene id: 9925:RCAN1
uniprot id: A0A452FI22
uniprot id: A0A452FIE4
names: Similarity
messages: Belongs to the RCAN family.

9925:SHANK2
gene id: 9925:SHANK2
uniprot id: A0A452FUR6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.
messages: Postsynaptic density

9925:HSD17B3
gene id: 9925:HSD17B3
uniprot id: A0A452GAM8
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:LOC102179376
gene id: 9925:LOC102179376
uniprot id: A0A452DVX8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TCP11L2
gene id: 9925:TCP11L2
uniprot id: A0A452EL43
names: Similarity
messages: Belongs to the TCP11 family.

9925:TLE4
gene id: 9925:TLE4
uniprot id: A0A452FAF4
uniprot id: A0A452FAS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat Groucho/TLE family.
messages: Nucleus

9925:FAM135A
gene id: 9925:FAM135A
uniprot id: A0A452EHA0
names: Similarity
messages: Belongs to the FAM135 family.

9925:SDCCAG3
gene id: 9925:SDCCAG3
uniprot id: A0A452F6P7
uniprot id: A0A452F7B2
names: Similarity
messages: Belongs to the ENTR1 family.

9925:CMTM7
gene id: 9925:CMTM7
uniprot id: A0A452FLV2
names: Subcellular Location Annotation
messages: Membrane

9925:ITPRIP
gene id: 9925:ITPRIP
uniprot id: A0A452FFN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITPRIP family.
messages: Membrane

9925:TPO
gene id: 9925:TPO
uniprot id: A0A452FIT4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prostaglandin G/H synthase family.
messages: Interacts with DUOX1, DUOX2 and CYBA.
messages: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:TBX4
gene id: 9925:TBX4
uniprot id: A0A452FF81
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9925:ZNF326
gene id: 9925:ZNF326
uniprot id: A0A452EZZ9
uniprot id: A0A452F042
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AKAP95 family.
messages: Nucleus matrix

9925:NME7
gene id: 9925:NME7
uniprot id: A0A452E1D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: cilium axoneme

9925:IMPACT
gene id: 9925:IMPACT
uniprot id: A0A452DKQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IMPACT family.
messages: Cytoplasm

9925:SLC12A7
gene id: 9925:SLC12A7
uniprot id: A0A452F6W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9925:LOC102177329
gene id: 9925:LOC102177329
uniprot id: A0A452FHT9
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:PTTG1
gene id: 9925:PTTG1
uniprot id: A0A452GAU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the securin family.
messages: Cytoplasm
messages: Nucleus

9925:BET1
gene id: 9925:BET1
uniprot id: A0A452F8S7
names: Subcellular Location Annotation
messages: Membrane

9925:HLF
gene id: 9925:HLF
uniprot id: A0A452EDI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9925:PTCD2
gene id: 9925:PTCD2
uniprot id: A0A452EYJ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTCD2 family.
messages: Mitochondrion

9925:TARBP2
gene id: 9925:TARBP2
uniprot id: A0A8C2R993
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TARBP2 family.
messages: Cytoplasm
messages: Nucleus
messages: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1.
messages: Self-associates. Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with EIF2AK2/PKR and inhibits its protein kinase activity. Interacts with DHX9 and PRKRA. Interacts with DICER1, AGO2, MOV10, EIF6 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC).
messages: perinuclear region

9925:SLAIN1
gene id: 9925:SLAIN1
uniprot id: A0A8C2NL86
names: Similarity
messages: Belongs to the SLAIN motif-containing family.

9925:LOC102169103
gene id: 9925:LOC102169103
uniprot id: A0A8C2S9L9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PFKFB2
gene id: 9925:PFKFB2
uniprot id: A0A452FXL5
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9925:AK6
gene id: 9925:AK6
uniprot id: A0A452F332
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK6 subfamily.
messages: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.
messages: Cajal body
messages: Monomer and homodimer. Interacts with COIL (via C-terminus).
messages: nucleoplasm

9925:STX19
gene id: 9925:STX19
uniprot id: A0A452DNT7
names: Similarity
messages: Belongs to the syntaxin family.

9925:ANO4
gene id: 9925:ANO4
uniprot id: A0A452E8P4
uniprot id: A0A452E9C9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:GRM6
gene id: 9925:GRM6
uniprot id: A0A452FZU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9925:CHST14
gene id: 9925:CHST14
uniprot id: A0A452DR63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:CCNB2
gene id: 9925:CCNB2
uniprot id: A0A452EMV1
names: Similarity
messages: Belongs to the cyclin family.

9925:SGTA
gene id: 9925:SGTA
uniprot id: A0A452G497
names: Similarity
messages: Belongs to the SGT family.

9925:PPA1
gene id: 9925:PPA1
uniprot id: A0A452EUK4
names: Similarity
messages: Belongs to the PPase family.

9925:LOC108638298
gene id: 9925:LOC108638298
uniprot id: A0A452DSF7
names: Function
messages: The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulfur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa).

9925:BARHL1
gene id: 9925:BARHL1
uniprot id: A0A452FZC3
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102176942
gene id: 9925:LOC102176942
uniprot id: A0A452E624
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:IRF2BP2
gene id: 9925:IRF2BP2
uniprot id: A0A452E944
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRF2BP family.
messages: Nucleus

9925:LOC106502180
gene id: 9925:LOC106502180
uniprot id: A0A452E1R6
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9925:RBL2
gene id: 9925:RBL2
uniprot id: A0A452G0H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the retinoblastoma protein (RB) family.
messages: Nucleus

9925:SMIM8
gene id: 9925:SMIM8
uniprot id: A0A452EA43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM8 family.
messages: Membrane

9925:WNK1
gene id: 9925:WNK1
uniprot id: A0A452EAR1
uniprot id: A0A452EAZ9
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9925:RPS16
gene id: 9925:RPS16
uniprot id: A0A452FWU9
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

9925:LOC102177548
gene id: 9925:LOC102177548
uniprot id: A0A452E1J0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102169641
gene id: 9925:LOC102169641
uniprot id: A0A452EPP3
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

9925:RRAGA
gene id: 9925:RRAGA
uniprot id: A0A452DQZ4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTR/RAG GTP-binding protein family.
messages: Cytoplasm
messages: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.
messages: Lysosome

9925:HM13
gene id: 9925:HM13
uniprot id: A0A452GAF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9925:IAH1
gene id: 9925:IAH1
uniprot id: A0A452EVP3
names: Function
names: Similarity
messages: Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.
messages: Probable lipase.

9925:EHD2
gene id: 9925:EHD2
uniprot id: A0A452EA50
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9925:DCK
gene id: 9925:DCK
uniprot id: A0A452G244
names: Similarity
messages: Belongs to the DCK/DGK family.

9925:NACC1
gene id: 9925:NACC1
uniprot id: A0A452FUV1
names: Subcellular Location Annotation
messages: Nucleus

9925:DMRT3
gene id: 9925:DMRT3
uniprot id: A0A452EEU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9925:LOC102178508
gene id: 9925:LOC102178508
uniprot id: A0A452DXQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102180455
gene id: 9925:LOC102180455
uniprot id: A0A452F1L4
uniprot id: A0A452F1T0
uniprot id: A0A8C2N739
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9925:PACSIN1
gene id: 9925:PACSIN1
uniprot id: A0A452DZB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytosol
messages: ruffle membrane
messages: synaptosome

9925:CHRNE
gene id: 9925:CHRNE
uniprot id: A0A8C2SAJ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:KRT19
gene id: 9925:KRT19
uniprot id: A0A452FYB3
names: Similarity
messages: Belongs to the intermediate filament family.

9925:TBCA
gene id: 9925:TBCA
uniprot id: A0A452FI28
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TBCA family.
messages: Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.
messages: Tubulin-folding protein; involved in the early step of the tubulin folding pathway.
messages: cytoskeleton

9925:NOL12
gene id: 9925:NOL12
uniprot id: A0A452FK12
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRP17 family.
messages: Interacts with KIAA1191.
messages: nucleolus

9925:CRYGC
gene id: 9925:CRYGC
uniprot id: A0A452F310
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9925:MITF
gene id: 9925:MITF
uniprot id: A0A452FLK6
uniprot id: A0A452FM93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9925:MARCO
gene id: 9925:MARCO
uniprot id: A0A452FYZ2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:MPPED2
gene id: 9925:MPPED2
uniprot id: A0A452EZG7
names: Similarity
messages: Belongs to the UPF0046 family.

9925:RUNDC3A
gene id: 9925:RUNDC3A
uniprot id: A0A452FUK8
uniprot id: A0A8C2S0E2
uniprot id: A0A8C2S158
names: Similarity
messages: Belongs to the RUNDC3 family.

9925:CRISP1
gene id: 9925:CRISP1
uniprot id: D6PX60
names: Caution
names: Similarity
messages: Belongs to the CRISP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:NFIL3
gene id: 9925:NFIL3
uniprot id: A0A452DZZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death.
messages: Belongs to the bZIP family. NFIL3 subfamily.
messages: Homodimer. Binds DNA as a dimer.
messages: Nucleus

9925:TMC5
gene id: 9925:TMC5
uniprot id: A0A452FA18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMC family.
messages: Membrane

9925:MIGA2
gene id: 9925:MIGA2
uniprot id: A0A452FIV9
names: Similarity
messages: Belongs to the mitoguardin family.

9925:FAM32A
gene id: 9925:FAM32A
uniprot id: A0A452FG54
names: Similarity
messages: Belongs to the FAM32 family.

9925:SDAD1
gene id: 9925:SDAD1
uniprot id: A0A452DTF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SDA1 family.
messages: Required for 60S pre-ribosomal subunits export to the cytoplasm.
messages: nucleolus

9925:SLC17A8
gene id: 9925:SLC17A8
uniprot id: A0A452EXX9
names: Subcellular Location Annotation
messages: Membrane

9925:BMS1
gene id: 9925:BMS1
uniprot id: A0A452FSI8
names: Subcellular Location Annotation
messages: nucleolus

9925:PRDX1
gene id: 9925:PRDX1
uniprot id: A0A452E1R9
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9925:SLC17A2
gene id: 9925:SLC17A2
uniprot id: A0A452DW75
names: Subcellular Location Annotation
messages: Membrane

9925:SLC9A1
gene id: 9925:SLC9A1
uniprot id: A0A452FVM0
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9925:BMP1
gene id: 9925:BMP1
uniprot id: A0A452FSN3
names: Caution
names: Cofactor
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:MGME1
gene id: 9925:MGME1
uniprot id: A0A452DVL4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MGME1 family.
messages: Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair.
messages: Mitochondrion

9925:F11R
gene id: 9925:F11R
uniprot id: A0A452FHD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily.
messages: Cell membrane
messages: Membrane
messages: tight junction

9925:EFEMP2
gene id: 9925:EFEMP2
uniprot id: A0A452EXQ1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:PRMT3
gene id: 9925:PRMT3
uniprot id: A0A452EVN6
names: Subcellular Location Annotation
messages: Cytoplasm

9925:NDRG2
gene id: 9925:NDRG2
uniprot id: A0A452EAY4
uniprot id: A0A452EAZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDRG family.
messages: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.
messages: Cytoplasm

9925:HNRNPK
gene id: 9925:HNRNPK
uniprot id: A0A452EN49
uniprot id: D5K776
names: Subcellular Location Annotation
messages: Cytoplasm
messages: nucleoplasm
messages: podosome

9925:IZUMO3
gene id: 9925:IZUMO3
uniprot id: A0A452F4U9
names: Similarity
messages: Belongs to the Izumo family.

9925:PROC
gene id: 9925:PROC
uniprot id: A0A452F6K1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC108636623
gene id: 9925:LOC108636623
uniprot id: A0A452DYA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:CKS1B
gene id: 9925:CKS1B
uniprot id: A0A452ECB3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CKS family.
messages: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
messages: Forms a homohexamer that can probably bind six kinase subunits.

9925:PHKG1
gene id: 9925:PHKG1
uniprot id: A0A452FGA5
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily.
messages: Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.

9925:FAM149A
gene id: 9925:FAM149A
uniprot id: A0A452ETY2
names: Similarity
messages: Belongs to the FAM149 family.

9925:LOC102175834
gene id: 9925:LOC102175834
uniprot id: A0A452E114
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:MMP27
gene id: 9925:MMP27
uniprot id: A0A452ED54
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9925:PHF1
gene id: 9925:PHF1
uniprot id: A0A452FRK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9925:CAB39
gene id: 9925:CAB39
uniprot id: A0A452FY20
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mo25 family.
messages: Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
messages: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

9925:IL20RA
gene id: 9925:IL20RA
uniprot id: A0A452EUF5
names: Subcellular Location Annotation
messages: Membrane

9925:ELF5
gene id: 9925:ELF5
uniprot id: A0A452EJQ9
uniprot id: X2CU32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9925:MON1A
gene id: 9925:MON1A
uniprot id: A0A452EKS5
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

9925:SLC12A3
gene id: 9925:SLC12A3
uniprot id: A0A452FPI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9925:KHDRBS1
gene id: 9925:KHDRBS1
uniprot id: A0A452EF54
names: Similarity
messages: Belongs to the KHDRBS family.

9925:LIN28A
gene id: 9925:LIN28A
uniprot id: A0A075TUV4
uniprot id: A0A452FF48
names: Similarity
messages: Belongs to the lin-28 family.

9925:LOC102168954
gene id: 9925:LOC102168954
uniprot id: A0A452DWV7
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9925:MSH4
gene id: 9925:MSH4
uniprot id: A0A452G769
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.

9925:LOC102169111
gene id: 9925:LOC102169111
uniprot id: A0A452DXU6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:MMACHC
gene id: 9925:MMACHC
uniprot id: A0A452G8L9
names: Similarity
messages: Belongs to the MMACHC family.

9925:GALNTL5
gene id: 9925:GALNTL5
uniprot id: A0A452F827
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Membrane

9925:HRH4
gene id: 9925:HRH4
uniprot id: A0A452DKI0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:KIF3B
gene id: 9925:KIF3B
uniprot id: A0A452GAB0
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9925:PTDSS1
gene id: 9925:PTDSS1
uniprot id: A0A452ER53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphatidyl serine synthase family.
messages: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:CDH11
gene id: 9925:CDH11
uniprot id: A0A452E2V9
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9925:SCTR
gene id: 9925:SCTR
uniprot id: A0A452FS22
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102174842
gene id: 9925:LOC102174842
uniprot id: A0A452DZP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:LTN1
gene id: 9925:LTN1
uniprot id: A0A452F206
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LTN1 family.
messages: Component of the ribosome quality control complex (RQC).
messages: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.
messages: cytosol

9925:FAHD1
gene id: 9925:FAHD1
uniprot id: A0A8C2RXH2
names: Similarity
messages: Belongs to the FAH family.

9925:WIF1
gene id: 9925:WIF1
uniprot id: A0A452EB31
names: Caution
names: Function
names: Subcellular Location Annotation
messages: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:NAGA
gene id: 9925:NAGA
uniprot id: A0A452G9E9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyl hydrolase 27 family.
messages: Homodimer.
messages: Lysosome

9925:SSH1
gene id: 9925:SSH1
uniprot id: A0A452E9I2
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

9925:SLC25A11
gene id: 9925:SLC25A11
uniprot id: A0A452FB58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:STMN4
gene id: 9925:STMN4
uniprot id: A0A452FDU8
uniprot id: A0A452FE73
uniprot id: A0A8C2XZP1
names: Similarity
messages: Belongs to the stathmin family.

9925:ADNP
gene id: 9925:ADNP
uniprot id: A0A452G9V2
names: Subcellular Location Annotation
messages: Nucleus

9925:PATL1
gene id: 9925:PATL1
uniprot id: A0A452G530
names: Similarity
messages: Belongs to the PAT1 family.

9925:RPL3
gene id: 9925:RPL3
uniprot id: A0A452G2Z1
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9925:IQCD
gene id: 9925:IQCD
uniprot id: A0A452F2L4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC10 family.
messages: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.
messages: flagellum axoneme

9925:FN3K
gene id: 9925:FN3K
uniprot id: A0A452FE83
names: Similarity
messages: Belongs to the fructosamine kinase family.

9925:PIGH
gene id: 9925:PIGH
uniprot id: A0A8C2RG18
names: Similarity
messages: Belongs to the PIGH family.

9925:GCLM
gene id: 9925:GCLM
uniprot id: A0A452G227
names: Similarity
names: Subunit
messages: Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.
messages: Heterodimer of a catalytic heavy chain and a regulatory light chain.

9925:LOC102185481
gene id: 9925:LOC102185481
uniprot id: A0A452DN99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TPRG1L
gene id: 9925:TPRG1L
uniprot id: A0A452DU01
names: Similarity
messages: Belongs to the TPRG1 family.

9925:TM6SF1
gene id: 9925:TM6SF1
uniprot id: A0A452FIL0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM6SF family.
messages: Membrane

9925:PWP2
gene id: 9925:PWP2
uniprot id: A0A8C2NP01
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat PWP2 family.
messages: nucleolus

9925:IFNA
gene id: 9925:IFNA
uniprot id: C5IU72
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:FAM229B
gene id: 9925:FAM229B
uniprot id: A0A452F538
names: Similarity
messages: Belongs to the FAM229 family.

9925:RASSF1
gene id: 9925:RASSF1
uniprot id: A0A452FEJ9
names: Subcellular Location Annotation
messages: cytoskeleton

9925:IQSEC3
gene id: 9925:IQSEC3
uniprot id: A0A452EW72
uniprot id: A0A452EW76
names: Similarity
messages: Belongs to the BRAG family.

9925:LOC102188781
gene id: 9925:LOC102188781
uniprot id: A0A452FLX5
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9925:SOX21
gene id: 9925:SOX21
uniprot id: A0A452FAF2
names: Subcellular Location Annotation
messages: Nucleus

9925:LRRC8B
gene id: 9925:LRRC8B
uniprot id: A0A452G5Y1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9925:LOC102177288
gene id: 9925:LOC102177288
uniprot id: A0A452DQX3
names: Similarity
messages: Belongs to the actin family.

9925:RSBN1L
gene id: 9925:RSBN1L
uniprot id: A0A452DS50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

9925:PIAS4
gene id: 9925:PIAS4
uniprot id: A0A452EQ32
names: Similarity
messages: Belongs to the PIAS family.

9925:RWDD3
gene id: 9925:RWDD3
uniprot id: A0A452ECB5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:GPR180
gene id: 9925:GPR180
uniprot id: A0A452EXE0
names: Subcellular Location Annotation
messages: Membrane

9925:CRABP2
gene id: 9925:CRABP2
uniprot id: A0A0A7CPQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9925:RCAN2
gene id: 9925:RCAN2
uniprot id: A0A452F4K4
names: Function
names: Similarity
messages: Belongs to the RCAN family.
messages: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

9925:GADD45GIP1
gene id: 9925:GADD45GIP1
uniprot id: A0A452F2F8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
messages: Belongs to the mitochondrion-specific ribosomal protein mL64 family.
messages: Mitochondrion
messages: Nucleus

9925:OPRK1
gene id: 9925:OPRK1
uniprot id: A0A452FSH1
uniprot id: W0T0L9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
messages: Interacts with NHERF1. Interacts with GABARAPL1.
messages: Membrane

9925:ASPN
gene id: 9925:ASPN
uniprot id: A0A452ESI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
messages: extracellular matrix

9925:PRKG2
gene id: 9925:PRKG2
uniprot id: A0A452EPF5
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.

9925:ZEB1
gene id: 9925:ZEB1
uniprot id: A0A452EVD0
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

9925:PSD
gene id: 9925:PSD
uniprot id: A0A452EUS8
names: Subcellular Location Annotation
messages: Membrane
messages: ruffle membrane

9925:LOC102188471
gene id: 9925:LOC102188471
uniprot id: A0A452F848
names: Similarity
messages: Belongs to the CSN9 family.

9925:HINT2
gene id: 9925:HINT2
uniprot id: A0A452E2L2
names: Similarity
messages: Belongs to the HINT family.

9925:PDIA6
gene id: 9925:PDIA6
uniprot id: A0A452DVG8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein disulfide isomerase family.
messages: Endoplasmic reticulum lumen
messages: Melanosome

9925:NEK9
gene id: 9925:NEK9
uniprot id: A0A452FPB7
names: Similarity
messages: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.

9925:CCNA2
gene id: 9925:CCNA2
uniprot id: A0A452F227
names: Similarity
messages: Belongs to the cyclin family. Cyclin AB subfamily.

9925:LOC102173140
gene id: 9925:LOC102173140
uniprot id: A0A452DSS3
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9925:MCU
gene id: 9925:MCU
uniprot id: A0A452F8G5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.
messages: Mitochondrion inner membrane

9925:SPACA3
gene id: 9925:SPACA3
uniprot id: D7R6C7
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9925:HNF4G
gene id: 9925:HNF4G
uniprot id: A0A452DMD8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Nucleus

9925:SKIV2L
gene id: 9925:SKIV2L
uniprot id: A0A452EEJ2
names: Subcellular Location Annotation
messages: Cytoplasm

9925:LOC108633473
gene id: 9925:LOC108633473
uniprot id: A0A452G9Y1
names: Similarity
messages: Belongs to the serpin family.

9925:INA
gene id: 9925:INA
uniprot id: A0A452FIN8
names: Similarity
messages: Belongs to the intermediate filament family.

9925:TWF1
gene id: 9925:TWF1
uniprot id: A0A452FSY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
messages: cytoskeleton

9925:A4GNT
gene id: 9925:A4GNT
uniprot id: A0A452F1M7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 32 family.
messages: Golgi apparatus membrane

9925:FAM160B1
gene id: 9925:FAM160B1
uniprot id: A0A452FF64
names: Similarity
messages: Belongs to the FHIP family.

9925:PDGFD
gene id: 9925:PDGFD
uniprot id: A0A452DTD6
names: Caution
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:CRYGN
gene id: 9925:CRYGN
uniprot id: A0A452GB80
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9925:CRYGS
gene id: 9925:CRYGS
uniprot id: A0A452FNS3
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9925:NDST3
gene id: 9925:NDST3
uniprot id: A0A452ESG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9925:PIGM
gene id: 9925:PIGM
uniprot id: A0A452DSW2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGM family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.
messages: Membrane

9925:TCEB1
gene id: 9925:TCEB1
uniprot id: A0A452EPB9
names: Similarity
messages: Belongs to the SKP1 family.

9925:FOXN2
gene id: 9925:FOXN2
uniprot id: A0A452G440
names: Subcellular Location Annotation
messages: Nucleus

9925:HPS5
gene id: 9925:HPS5
uniprot id: A0A452E091
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HPS5 family.
messages: Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.
messages: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
messages: cytosol

9925:MAPK7
gene id: 9925:MAPK7
uniprot id: A0A452EIN2
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9925:LGI1
gene id: 9925:LGI1
uniprot id: A0A452FB69
names: Subcellular Location Annotation
messages: Secreted

9925:METTL3
gene id: 9925:METTL3
uniprot id: A0A452EWW0
names: Similarity
messages: Belongs to the MT-A70-like family.

9925:SPO11
gene id: 9925:SPO11
uniprot id: A0A452FWI4
names: Similarity
messages: Belongs to the TOP6A family.

9925:SH3PXD2B
gene id: 9925:SH3PXD2B
uniprot id: A0A452EZU4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3PXD2 family.
messages: Cytoplasm

9925:RPRD1B
gene id: 9925:RPRD1B
uniprot id: A0A0M3KWF7
names: Function
names: Similarity
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD.

9925:SFXN2
gene id: 9925:SFXN2
uniprot id: A0A8C2XUH8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9925:NAMPT
gene id: 9925:NAMPT
uniprot id: A0A452EHM0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAPRTase family.
messages: Cytoplasm
messages: Homodimer.
messages: Nucleus
messages: Secreted

9925:NKD2
gene id: 9925:NKD2
uniprot id: A0A452FPZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKD family.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway.
messages: Cell membrane
messages: Cytoplasm

9925:DAZL
gene id: 9925:DAZL
uniprot id: J9R1M9
names: Subcellular Location Annotation
messages: Cytoplasm

9925:SNUPN
gene id: 9925:SNUPN
uniprot id: A0A452F3J0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snurportin family.
messages: Cytoplasm
messages: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
messages: Nucleus

9925:ESYT2
gene id: 9925:ESYT2
uniprot id: A0A452ED67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the extended synaptotagmin family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:SCARB1
gene id: 9925:SCARB1
uniprot id: A0A452F386
names: Similarity
messages: Belongs to the CD36 family.

9925:SLC16A8
gene id: 9925:SLC16A8
uniprot id: A0A452ES12
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
messages: Membrane

9925:TEX10
gene id: 9925:TEX10
uniprot id: A0A452EE10
names: Similarity
messages: Belongs to the IPI1/TEX10 family.

9925:AQP2
gene id: 9925:AQP2
uniprot id: A0A452FW03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9925:YPEL3
gene id: 9925:YPEL3
uniprot id: A0A452FKY5
names: Similarity
messages: Belongs to the yippee family.

9925:AQP4
gene id: 9925:AQP4
uniprot id: A0A452E2K9
uniprot id: A0A452E2M8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9925:NINJ1
gene id: 9925:NINJ1
uniprot id: A0A452F4U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ninjurin family.
messages: Membrane

9925:MEGF8
gene id: 9925:MEGF8
uniprot id: A0A452ENX2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:LOC102181002
gene id: 9925:LOC102181002
uniprot id: A0A452ELP7
names: Similarity
messages: Belongs to the peptidase A1 family.

9925:PIK3CD
gene id: 9925:PIK3CD
uniprot id: A0A452FD91
uniprot id: A0A8C2RE34
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9925:SFXN1
gene id: 9925:SFXN1
uniprot id: A0A452FNP4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Mitochondrion membrane

9925:TUFM
gene id: 9925:TUFM
uniprot id: A0A452FF42
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9925:CCDC90B
gene id: 9925:CCDC90B
uniprot id: A0A452FRV6
names: Similarity
messages: Belongs to the CCDC90 family.

9925:ATP5F1
gene id: 9925:ATP5F1
uniprot id: A0A452EBH4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ATPase B chain family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(0) has three main subunits: a, b and c.
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9925:STK17A
gene id: 9925:STK17A
uniprot id: A0A452EEA2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:LOC102173207
gene id: 9925:LOC102173207
uniprot id: A0A452G190
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase CarF family.
messages: Membrane

9925:IMPA1
gene id: 9925:IMPA1
uniprot id: A0A452EUA9
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9925:RC3H1
gene id: 9925:RC3H1
uniprot id: A0A452DP18
names: Subcellular Location Annotation
messages: P-body

9925:CASP9
gene id: 9925:CASP9
uniprot id: A0A452E8W3
names: Similarity
messages: Belongs to the peptidase C14A family.

9925:SNX11
gene id: 9925:SNX11
uniprot id: A0A452F0R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9925:ERLIN2
gene id: 9925:ERLIN2
uniprot id: A0A452G6G9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the band 7/mec-2 family.
messages: Endoplasmic reticulum membrane
messages: Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.
messages: Membrane

9925:NCOA1
gene id: 9925:NCOA1
uniprot id: A0A452EWH7
uniprot id: A0A452EWI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRC/p160 nuclear receptor coactivator family.
messages: Nucleus

9925:ADCYAP1
gene id: 9925:ADCYAP1
uniprot id: A0A452DLC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9925:FAM124A
gene id: 9925:FAM124A
uniprot id: A0A452F120
names: Similarity
messages: Belongs to the FAM124 family.

9925:LIF
gene id: 9925:LIF
uniprot id: A0A452EKJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LIF/OSM family.
messages: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
messages: Secreted

9925:DMRT1
gene id: 9925:DMRT1
uniprot id: A0A452FX24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9925:HSD17B1
gene id: 9925:HSD17B1
uniprot id: A0A452FYT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Favors the reduction of estrogens and androgens. Uses preferentially NADH.

9925:ACVR1B
gene id: 9925:ACVR1B
uniprot id: A0A452F5H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9925:C15H11orf70
gene id: 9925:C15H11orf70
uniprot id: A0A452DYQ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CFAP300 family.
messages: Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.
messages: Cytoplasm

9925:ARG1
gene id: 9925:ARG1
uniprot id: C6K4R6
names: Cofactor
names: Similarity
messages: Belongs to the arginase family.
messages: Binds 2 manganese ions per subunit.

9925:MDM1
gene id: 9925:MDM1
uniprot id: A0A452FTG0
uniprot id: A0A452FTI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MDM1 family.
messages: Nucleus
messages: centriole

9925:GNG12
gene id: 9925:GNG12
uniprot id: A0A452ERK1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9925:CTGF
gene id: 9925:CTGF
uniprot id: A0A452G077
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:LOC102185550
gene id: 9925:LOC102185550
uniprot id: A0A452EBJ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:HOMER1
gene id: 9925:HOMER1
uniprot id: A0A452G4P0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Homer family.
messages: Cytoplasm
messages: Postsynaptic density
messages: Synapse

9925:TJAP1
gene id: 9925:TJAP1
uniprot id: A0A452FJQ4
names: Subcellular Location Annotation
messages: Membrane

9925:TACC2
gene id: 9925:TACC2
uniprot id: A0A452EFN5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: Cytoplasm

9925:FAT4
gene id: 9925:FAT4
uniprot id: A0A452ESS9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LHB
gene id: 9925:LHB
uniprot id: Q1RP71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9925:MRPL37
gene id: 9925:MRPL37
uniprot id: A0A452EYL5
names: Subcellular Location Annotation
messages: Mitochondrion

9925:BGLAP
gene id: 9925:BGLAP
uniprot id: A0A8C2NFR8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Binds strongly to apatite and calcium.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Secreted

9925:LOC102189696
gene id: 9925:LOC102189696
uniprot id: A0A452DUY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PHACTR2
gene id: 9925:PHACTR2
uniprot id: A0A452EJT7
names: Similarity
names: Subunit
messages: Belongs to the phosphatase and actin regulator family.
messages: Binds PPP1CA and actin.

9925:KDSR
gene id: 9925:KDSR
uniprot id: A0A452FG25
uniprot id: A0A452FG85
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:CCKBR
gene id: 9925:CCKBR
uniprot id: A0A452F475
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:PYCR1
gene id: 9925:PYCR1
uniprot id: A0A452G933
names: Similarity
messages: Belongs to the pyrroline-5-carboxylate reductase family.

9925:GIF
gene id: 9925:GIF
uniprot id: A0A452EXR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic cobalamin transport proteins family.
messages: Secreted

9925:C15H11orf1
gene id: 9925:C15H11orf1
uniprot id: A0A452G586
names: Function
names: Subcellular Location Annotation
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
messages: cilium axoneme

9925:TMCC1
gene id: 9925:TMCC1
uniprot id: A0A452EWZ1
names: Similarity
messages: Belongs to the TEX28 family.

9925:DLK2
gene id: 9925:DLK2
uniprot id: A0A452DR75
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102184867
gene id: 9925:LOC102184867
uniprot id: A0A452DYY4
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:GBAS
gene id: 9925:GBAS
uniprot id: A0A452F7R4
names: Similarity
messages: Belongs to the NipSnap family.

9925:TNNT1
gene id: 9925:TNNT1
uniprot id: W8FZK0
names: Function
names: Similarity
messages: Belongs to the troponin T family.
messages: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

9925:LOC102181408
gene id: 9925:LOC102181408
uniprot id: A0A452E9X5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:MKX
gene id: 9925:MKX
uniprot id: A0A452FKX0
names: Subcellular Location Annotation
messages: Nucleus

9925:GGA3
gene id: 9925:GGA3
uniprot id: A0A452DP37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

9925:AP1G1
gene id: 9925:AP1G1
uniprot id: A0A452DTT2
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9925:PPP3CA
gene id: 9925:PPP3CA
uniprot id: A0A452G896
uniprot id: A0A452G8C4
names: Similarity
messages: Belongs to the PPP phosphatase family. PP-2B subfamily.

9925:LOC102177561
gene id: 9925:LOC102177561
uniprot id: A0A452DXK1
names: Function
messages: The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulfur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa).

9925:SUPT20H
gene id: 9925:SUPT20H
uniprot id: A0A452E4P5
names: Similarity
messages: Belongs to the SPT20 family.

9925:LOC100861136
gene id: 9925:LOC100861136
uniprot id: A0A452E2N1
names: Subcellular Location Annotation
messages: Membrane

9925:CD34
gene id: 9925:CD34
uniprot id: A0A452DS98
names: Subcellular Location Annotation
messages: Membrane

9925:P4HA1
gene id: 9925:P4HA1
uniprot id: A0A452EJ18
uniprot id: A0A452EJK8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9925:PEX1
gene id: 9925:PEX1
uniprot id: A0A452GBG1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: cytosol

9925:KEF96 p03
gene id: 9925:KEF96_p03
uniprot id: E0XJX1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 5 family.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9925:LOC102187315
gene id: 9925:LOC102187315
uniprot id: A0A452DPC2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:YRDC
gene id: 9925:YRDC
uniprot id: A0A452DV91
names: Similarity
messages: Belongs to the SUA5 family.

9925:ARAP3
gene id: 9925:ARAP3
uniprot id: A0A452E0G6
names: Subcellular Location Annotation
messages: Cytoplasm

9925:UCN
gene id: 9925:UCN
uniprot id: A0A8C2QW74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Secreted

9925:NKX3-2
gene id: 9925:NKX3-2
uniprot id: A0A452E6U2
names: Subcellular Location Annotation
messages: Nucleus

9925:NAPB
gene id: 9925:NAPB
uniprot id: A0A452FD59
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNAP family.
messages: Membrane
messages: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

9925:TOB1
gene id: 9925:TOB1
uniprot id: A0A452DQ17
names: Similarity
messages: Belongs to the BTG family.

9925:REM2
gene id: 9925:REM2
uniprot id: A0A452EAY7
names: Subcellular Location Annotation
messages: Cell membrane

9925:SMOC1
gene id: 9925:SMOC1
uniprot id: A0A452E8Q4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:INSIG1
gene id: 9925:INSIG1
uniprot id: I1WZP5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INSIG family.
messages: Endoplasmic reticulum membrane
messages: Mediates feedback control of cholesterol synthesis.
messages: Membrane

9925:CTC1
gene id: 9925:CTC1
uniprot id: A0A452G019
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CTC1 family.
messages: Nucleus
messages: telomere

9925:C18H19orf12
gene id: 9925:C18H19orf12
uniprot id: A0A452FTC3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the C19orf12 family.
messages: Mitochondrion membrane

9925:LOC102190691
gene id: 9925:LOC102190691
uniprot id: A0A452G0Q7
names: Similarity
messages: Belongs to the DNAJC25 family.

9925:UBE4A
gene id: 9925:UBE4A
uniprot id: A0A452F377
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin conjugation factor E4 family.
messages: Cytoplasm
messages: The U-box domain is required for the ubiquitin protein ligase activity.
messages: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Also functions as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates.

9925:ZAR1
gene id: 9925:ZAR1
uniprot id: A0A452F5Q9
names: Similarity
names: Subunit
messages: Belongs to the ZAR1 family.
messages: Interacts with YBX2.

9925:DHX8
gene id: 9925:DHX8
uniprot id: A0A452DZC2
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102177846
gene id: 9925:LOC102177846
uniprot id: A0A452DNE3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains (PubMed:6504138, PubMed:2207090, PubMed:7704569). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:6504138, PubMed:2207090, PubMed:7704569). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:6504138, PubMed:2207090, PubMed:7704569).
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9925:NUP58
gene id: 9925:NUP58
uniprot id: A0A452E096
names: Subcellular Location Annotation
messages: nuclear pore complex

9925:LOC102182773
gene id: 9925:LOC102182773
uniprot id: A0A452EBG6
names: Similarity
names: Subunit
messages: Homooctamer.
messages: In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.
messages: In the N-terminal section; belongs to the SAICAR synthetase family.

9925:SHMT1
gene id: 9925:SHMT1
uniprot id: A0A452EH27
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

9925:ABCD4
gene id: 9925:ABCD4
uniprot id: A0A452EZP4
names: Subcellular Location Annotation
messages: Membrane

9925:EPC1
gene id: 9925:EPC1
uniprot id: A0A452DRY9
uniprot id: A0A452DS09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enhancer of polycomb family.
messages: Nucleus

9925:PADI3
gene id: 9925:PADI3
uniprot id: A0A452E2U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9925:LOC106503078
gene id: 9925:LOC106503078
uniprot id: A0A452EW59
names: Similarity
messages: Belongs to the GcvT family.

9925:VARS
gene id: 9925:VARS
uniprot id: A0A452E6L4
uniprot id: A0A452E6R0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9925:AASDHPPT
gene id: 9925:AASDHPPT
uniprot id: A0A452F1Y2
names: Similarity
messages: Belongs to the P-Pant transferase superfamily. AcpS family.

9925:LOC102175073
gene id: 9925:LOC102175073
uniprot id: A0A452DR36
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CRHBP
gene id: 9925:CRHBP
uniprot id: A0A452FX32
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CRF-binding protein family.
messages: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.
messages: Secreted

9925:DVL3
gene id: 9925:DVL3
uniprot id: A0A452EF16
names: Similarity
messages: Belongs to the DSH family.

9925:CASKIN2
gene id: 9925:CASKIN2
uniprot id: A0A452FKC2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9925:SLC7A5
gene id: 9925:SLC7A5
uniprot id: A0A452FBF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.
messages: Cell membrane
messages: Membrane

9925:FAM131A
gene id: 9925:FAM131A
uniprot id: A0A8C2PE90
uniprot id: A0A8C2PGZ7
names: Similarity
messages: Belongs to the FAM131 family.

9925:SLC25A25
gene id: 9925:SLC25A25
uniprot id: A0A452FJC7
uniprot id: A0A452FJV9
uniprot id: A0A8C2RK58
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9925:SLC35B1
gene id: 9925:SLC35B1
uniprot id: A0A452F081
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
messages: Membrane

9925:TFAP2D
gene id: 9925:TFAP2D
uniprot id: A0A452FSN5
names: Similarity
messages: Belongs to the AP-2 family.

9925:GNRH1
gene id: 9925:GNRH1
uniprot id: A0A452EVB9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GnRH family.
messages: Secreted
messages: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

9925:NEFL
gene id: 9925:NEFL
uniprot id: A0A452EA90
names: Similarity
messages: Belongs to the intermediate filament family.

9925:ATP5L
gene id: 9925:ATP5L
uniprot id: A0A452DYD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

9925:FECH
gene id: 9925:FECH
uniprot id: A0A452ETQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Mitochondrion inner membrane

9925:FGF9
gene id: 9925:FGF9
uniprot id: A0A452FF06
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9925:SPARC
gene id: 9925:SPARC
uniprot id: A9LLG1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
messages: Belongs to the SPARC family.
messages: Membrane
messages: basement membrane

9925:ADORA2B
gene id: 9925:ADORA2B
uniprot id: A0A452EWS9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

9925:C11H9orf78
gene id: 9925:C11H9orf78
uniprot id: A0A452GA07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TLS1 family.
messages: Nucleus

9925:DNAAF1
gene id: 9925:DNAAF1
uniprot id: A0A452DTY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNAAF1 family.
messages: Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli.
messages: cilium

9925:SMAD3
gene id: 9925:SMAD3
uniprot id: A0A452EI09
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dwarfin/SMAD family.
messages: Cytoplasm
messages: Nucleus

9925:RAB3IP
gene id: 9925:RAB3IP
uniprot id: A0A452E2Y1
names: Similarity
messages: Belongs to the SEC2 family.

9925:FBXO48
gene id: 9925:FBXO48
uniprot id: A0A452F3K1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO9) composed of CUL1, SKP1, RBX1 and FBXO9. Interacts with TTI1 and TELO2; when TTI1 and TELO2 are phosphorylated by CK2.
messages: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway. Regulates also PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation.

9925:UPK1B
gene id: 9925:UPK1B
uniprot id: A0A452G537
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9925:NFS1
gene id: 9925:NFS1
uniprot id: A0A452F2X7
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.

9925:PEX5L
gene id: 9925:PEX5L
uniprot id: A0A452FKC4
uniprot id: A0A452FKV8
uniprot id: A0A8C2RZI0
names: Similarity
messages: Belongs to the peroxisomal targeting signal receptor family.

9925:ASIC3
gene id: 9925:ASIC3
uniprot id: A0A452ERK5
names: Subcellular Location Annotation
messages: Membrane

9925:GPX8
gene id: 9925:GPX8
uniprot id: A0A452FPY4
names: Similarity
messages: Belongs to the glutathione peroxidase family.

9925:EPB42
gene id: 9925:EPB42
uniprot id: A0A452FSQ7
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.

9925:XIRP1
gene id: 9925:XIRP1
uniprot id: A0A452EB48
names: Domain
names: Function
names: Similarity
messages: Belongs to the Xin family.
messages: Protects actin filaments from depolymerization.
messages: Xin repeats bind F-actin.

9925:OTUB2
gene id: 9925:OTUB2
uniprot id: A0A452FF73
names: Similarity
messages: Belongs to the peptidase C65 family.

9925:VPS18
gene id: 9925:VPS18
uniprot id: A0A452FYQ4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS18 family.
messages: Membrane

9925:YARS2
gene id: 9925:YARS2
uniprot id: A0A452DNJ8
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9925:CACNB3
gene id: 9925:CACNB3
uniprot id: A0A452ECF7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: Cytoplasm

9925:LCMT1
gene id: 9925:LCMT1
uniprot id: A0A452EQV1
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. LCMT family.
messages: Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

9925:FURIN
gene id: 9925:FURIN
uniprot id: A0A452FNT1
names: Similarity
messages: Belongs to the peptidase S8 family.

9925:LOC102169702
gene id: 9925:LOC102169702
uniprot id: A0A452F5Z1
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the lipoxygenase family.
messages: Binds 1 Fe cation per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:GDF2
gene id: 9925:GDF2
uniprot id: A0A452F3N3
names: Similarity
messages: Belongs to the TGF-beta family.

9925:LOC102175229
gene id: 9925:LOC102175229
uniprot id: A0A452DWA2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:FXYD5
gene id: 9925:FXYD5
uniprot id: A0A452G9T5
names: Similarity
messages: Belongs to the FXYD family.

9925:TXNRD1
gene id: 9925:TXNRD1
uniprot id: A0A452FGF2
uniprot id: A0A452FGQ8
names: Cofactor
names: Similarity
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.

9925:MAP3K10
gene id: 9925:MAP3K10
uniprot id: A0A452F957
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

9925:EVA1C
gene id: 9925:EVA1C
uniprot id: A0A452EYH0
uniprot id: A0A452EYU6
names: Similarity
messages: Belongs to the EVA1 family.

9925:SETD3
gene id: 9925:SETD3
uniprot id: A0A452E8X8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.
messages: Cytoplasm
messages: Interacts with MYOD1.

9925:MAS1
gene id: 9925:MAS1
uniprot id: A0A452EEQ1
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:SLC34A2
gene id: 9925:SLC34A2
uniprot id: A0A452ERT5
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

9925:MYO5A
gene id: 9925:MYO5A
uniprot id: A0A452FET7
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9925:HOOK2
gene id: 9925:HOOK2
uniprot id: A0A452F265
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hook family.
messages: cytoskeleton

9925:ARID3C
gene id: 9925:ARID3C
uniprot id: A0A452EXR2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Homodimer.
messages: Nucleus
messages: Transcription factor.

9925:NUDT21
gene id: 9925:NUDT21
uniprot id: A0A452G8A2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Nudix hydrolase family. CPSF5 subfamily.
messages: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.
messages: Cytoplasm
messages: Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.
messages: Nucleus

9925:NGRN
gene id: 9925:NGRN
uniprot id: A0A452DRY8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the neugrin family.
messages: Forms a regulatory protein-RNA complex, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA. Interacts with 16S mt-rRNA; this interaction is direct.
messages: Mitochondrion membrane
messages: Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system.

9925:TNP2
gene id: 9925:TNP2
uniprot id: A0A8C2RKQ3
names: Function
names: Similarity
messages: Belongs to the nuclear transition protein 2 family.
messages: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.

9925:PITHD1
gene id: 9925:PITHD1
uniprot id: A0A452E7M6
names: Similarity
messages: Belongs to the PITHD1 family.

9925:CTBP1
gene id: 9925:CTBP1
uniprot id: A0A452G220
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
messages: Nucleus

9925:LOC102172331
gene id: 9925:LOC102172331
uniprot id: M9PPI4
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9925:PLEKHA8
gene id: 9925:PLEKHA8
uniprot id: A0A452FQC3
names: Subcellular Location Annotation
messages: trans-Golgi network membrane

9925:PYGL
gene id: 9925:PYGL
uniprot id: A0A452G9U4
names: Function
names: Similarity
messages: Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
messages: Belongs to the glycogen phosphorylase family.

9925:CLRN3
gene id: 9925:CLRN3
uniprot id: A0A452EEY4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clarin family.
messages: Membrane

9925:TMEM258
gene id: 9925:TMEM258
uniprot id: A0A8C2SB61
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OST5 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9925:NAV3
gene id: 9925:NAV3
uniprot id: A0A452EBE9
uniprot id: A0A452EBV3
uniprot id: A0A452EBZ5
uniprot id: A0A452EC65
names: Similarity
messages: Belongs to the Nav/unc-53 family.

9925:TMEM218
gene id: 9925:TMEM218
uniprot id: A0A452G323
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM218 family.
messages: May be involved in ciliary biogenesis or function.
messages: Membrane
messages: cilium

9925:VPS35
gene id: 9925:VPS35
uniprot id: A0A452G510
names: Function
names: Similarity
messages: Belongs to the VPS35 family.
messages: Plays a role in vesicular protein sorting.

9925:AGPAT3
gene id: 9925:AGPAT3
uniprot id: A0A452F818
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9925:WNT2B
gene id: 9925:WNT2B
uniprot id: A0A452DYJ8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9925:FUZ
gene id: 9925:FUZ
uniprot id: A0A452FIN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fuzzy family.
messages: cytoskeleton

9925:B4GALT5
gene id: 9925:B4GALT5
uniprot id: A0A452EZN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9925:B3GNT3
gene id: 9925:B3GNT3
uniprot id: A0A452G4Q5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:LOC102189488
gene id: 9925:LOC102189488
uniprot id: A0A452FYD6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the protein prenyltransferase subunit beta family.
messages: Binds 1 zinc ion per subunit.
messages: Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.
messages: Heterodimer of FNTA and FNTB.

9925:LOC102188049
gene id: 9925:LOC102188049
uniprot id: A0A452DSH8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:AASDH
gene id: 9925:AASDH
uniprot id: A0A452FN21
uniprot id: A0A452FN36
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9925:YKT6
gene id: 9925:YKT6
uniprot id: A0A452G9Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptobrevin family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity.

9925:LOC102175177
gene id: 9925:LOC102175177
uniprot id: A0A452E1G6
names: Subcellular Location Annotation
messages: Cell membrane

9925:CCNG1
gene id: 9925:CCNG1
uniprot id: A0A452DQR8
names: Similarity
messages: Belongs to the cyclin family.

9925:GALNTL6
gene id: 9925:GALNTL6
uniprot id: A0A8C2QW02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9925:APOC3
gene id: 9925:APOC3
uniprot id: A0A452EM11
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the apolipoprotein C3 family.
messages: Secreted

9925:SPC25
gene id: 9925:SPC25
uniprot id: A0A452FFW3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC25 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9925:OPN1SW
gene id: 9925:OPN1SW
uniprot id: A0A452F0H0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.
messages: Membrane
messages: Photoreceptor inner segment
messages: photoreceptor outer segment

9925:SEC11C
gene id: 9925:SEC11C
uniprot id: A0A452DTE6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S26B family.
messages: Component of the signal peptidase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:PHLDA1
gene id: 9925:PHLDA1
uniprot id: A0A452DR04
names: Subcellular Location Annotation
messages: Cytoplasm

9925:DDX5
gene id: 9925:DDX5
uniprot id: A0A452E9Y3
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.

9925:IRX5
gene id: 9925:IRX5
uniprot id: A0A452EB64
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/IRO homeobox family.
messages: Nucleus

9925:LOC108637993
gene id: 9925:LOC108637993
uniprot id: A0A452F701
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNF-like-inhibitor family.
messages: Secreted

9925:CORO1B
gene id: 9925:CORO1B
uniprot id: A0A452F0Q2
names: Similarity
messages: Belongs to the WD repeat coronin family.

9925:CLPP
gene id: 9925:CLPP
uniprot id: A0A452FS09
names: Similarity
messages: Belongs to the peptidase S14 family.

9925:LOC102186401
gene id: 9925:LOC102186401
uniprot id: A0A452EFE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SFN
gene id: 9925:SFN
uniprot id: A0A452DME8
names: Similarity
messages: Belongs to the 14-3-3 family.

9925:MAT2A
gene id: 9925:MAT2A
uniprot id: A0A8C2P6P0
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.
messages: Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.
messages: Catalyzes the formation of S-adenosylmethionine from methionine and ATP.

9925:NDUFC1
gene id: 9925:NDUFC1
uniprot id: A0A452ETM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9925:ACTA2
gene id: 9925:ACTA2
uniprot id: A0A452F296
names: Similarity
messages: Belongs to the actin family.

9925:HCN1
gene id: 9925:HCN1
uniprot id: A0A452G059
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9925:PDGFB
gene id: 9925:PDGFB
uniprot id: A0A452G438
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9925:TSN
gene id: 9925:TSN
uniprot id: A0A452E566
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the translin family.
messages: DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.
messages: Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.
messages: Nucleus
messages: Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring.

9925:TAF5
gene id: 9925:TAF5
uniprot id: A0A8C2R2B2
names: Similarity
messages: Belongs to the WD repeat TAF5 family.

9925:SGPL1
gene id: 9925:SGPL1
uniprot id: A0A452EJV8
names: Similarity
messages: Belongs to the group II decarboxylase family.

9925:ITGB6
gene id: 9925:ITGB6
uniprot id: A0A452EJ04
uniprot id: J7GY82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

9925:UBA52
gene id: 9925:UBA52
uniprot id: A0A452FYQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.
messages: In the N-terminal section; belongs to the ubiquitin family.
messages: Nucleus
messages: Part of the 60S ribosomal subunit. Interacts with UBQLN1 (via UBA domain).

9925:NBR1
gene id: 9925:NBR1
uniprot id: A0A452FT88
names: Subcellular Location Annotation
messages: Lysosome
messages: autophagosome

9925:THEMIS2
gene id: 9925:THEMIS2
uniprot id: A0A452EDD8
names: Similarity
messages: Belongs to the themis family.

9925:ASF1A
gene id: 9925:ASF1A
uniprot id: A0A452DX55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9925:MMP20
gene id: 9925:MMP20
uniprot id: A0A452G6Y7
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9925:LOC106503663
gene id: 9925:LOC106503663
uniprot id: A0A059TZ03
uniprot id: A0A452ELJ1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9925:NPC2
gene id: 9925:NPC2
uniprot id: A0A452F982
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPC2 family.
messages: Secreted

9925:PEMT
gene id: 9925:PEMT
uniprot id: A0A452DY36
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.
messages: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Mitochondrion membrane

9925:NUP133
gene id: 9925:NUP133
uniprot id: A0A452G6M0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleoporin Nup133 family.
messages: nuclear pore complex

9925:RAG2
gene id: 9925:RAG2
uniprot id: A0A452DZ81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAG2 family.
messages: Nucleus

9925:ABCC3
gene id: 9925:ABCC3
uniprot id: A0A452EPE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

9925:LOC102191036
gene id: 9925:LOC102191036
uniprot id: A0A452DPP3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:HOGA1
gene id: 9925:HOGA1
uniprot id: A0A452F4W2
uniprot id: A0A8C2PLJ2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the final step in the metabolic pathway of hydroxyproline.
messages: Homotetramer.

9925:PON2
gene id: 9925:PON2
uniprot id: A0A452FRQ4
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the paraoxonase family.
messages: Binds 2 calcium ions per subunit.
messages: Glycosylated.

9925:PUS7L
gene id: 9925:PUS7L
uniprot id: A0A452E7S8
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.

9925:GUCY2D
gene id: 9925:GUCY2D
uniprot id: A0A452EPN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane
messages: Photoreceptor outer segment membrane

9925:GINS2
gene id: 9925:GINS2
uniprot id: A0A452EV02
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS2/PSF2 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus

9925:RIBC2
gene id: 9925:RIBC2
uniprot id: A0A452F7L7
names: Similarity
messages: Belongs to the RIB43A family.

9925:SLC43A2
gene id: 9925:SLC43A2
uniprot id: A0A452FRS2
names: Subcellular Location Annotation
messages: Membrane

9925:CENPV
gene id: 9925:CENPV
uniprot id: A0A452FZV7
names: Similarity
messages: Belongs to the Gfa family.

9925:EFS
gene id: 9925:EFS
uniprot id: A0A452G2I5
uniprot id: A0A8C2R7D3
names: Similarity
messages: Belongs to the CAS family.

9925:TMEM120A
gene id: 9925:TMEM120A
uniprot id: A0A452FS78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Nucleus inner membrane

9925:GK5
gene id: 9925:GK5
uniprot id: A0A452F2H8
names: Similarity
messages: Belongs to the FGGY kinase family.

9925:TMEM161B
gene id: 9925:TMEM161B
uniprot id: A0A452G872
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM161 family.
messages: Membrane

9925:SLC7A6
gene id: 9925:SLC7A6
uniprot id: A0A452E345
names: Subcellular Location Annotation
messages: Membrane

9925:PIPOX
gene id: 9925:PIPOX
uniprot id: A0A452E8J7
names: Similarity
messages: Belongs to the MSOX/MTOX family.

9925:LOC102168550
gene id: 9925:LOC102168550
uniprot id: A0A452DQS8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PDIK1L
gene id: 9925:PDIK1L
uniprot id: A0A452F8N9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:LOC102186384
gene id: 9925:LOC102186384
uniprot id: A0A452E604
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CBFA2T2
gene id: 9925:CBFA2T2
uniprot id: A0A452EZL3
names: Similarity
messages: Belongs to the CBFA2T family.

9925:NMB
gene id: 9925:NMB
uniprot id: A0A452E2K5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bombesin/neuromedin-B/ranatensin family.
messages: Secreted
messages: neuron projection

9925:TBC1D7
gene id: 9925:TBC1D7
uniprot id: A0A8C2S1P6
uniprot id: G1DFS4
names: Subcellular Location Annotation
messages: Cytoplasmic vesicle
messages: Vesicle

9925:RPL22L1
gene id: 9925:RPL22L1
uniprot id: A0A452E3C0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

9925:THEMIS
gene id: 9925:THEMIS
uniprot id: A0A452FBJ9
names: Similarity
messages: Belongs to the themis family.

9925:TRIM25
gene id: 9925:TRIM25
uniprot id: A0A452EC58
names: Subcellular Location Annotation
messages: Cytoplasm

9925:MT3
gene id: 9925:MT3
uniprot id: A5HC27
names: Function
names: Similarity
messages: Belongs to the metallothionein superfamily. Type 1 family.
messages: Metallothioneins have a high content of cysteine residues that bind various heavy metals.

9925:LOC102187052
gene id: 9925:LOC102187052
uniprot id: A0A8C2NYF8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CALR3
gene id: 9925:CALR3
uniprot id: A0A452EPL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calreticulin family.
messages: Endoplasmic reticulum lumen

9925:IRGQ
gene id: 9925:IRGQ
uniprot id: A0A452E2B2
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9925:KRT4
gene id: 9925:KRT4
uniprot id: A0A452G800
names: Similarity
messages: Belongs to the intermediate filament family.

9925:LGI3
gene id: 9925:LGI3
uniprot id: A0A452G2X6
names: Subcellular Location Annotation
messages: Secreted

9925:LOC102172084
gene id: 9925:LOC102172084
uniprot id: A0A452FYF4
uniprot id: A0A452FYV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mical family.
messages: Cytoplasm

9925:LOC102179183
gene id: 9925:LOC102179183
uniprot id: A0A452G2G6
names: Similarity
messages: Belongs to the 'GDXG' lipolytic enzyme family.

9925:ARHGAP32
gene id: 9925:ARHGAP32
uniprot id: A0A452F4I2
names: Similarity
messages: Belongs to the PX domain-containing GAP family.

9925:LOC102182981
gene id: 9925:LOC102182981
uniprot id: A0A452DMB9
names: Similarity
messages: Belongs to the SNURF family.

9925:LOC102186976
gene id: 9925:LOC102186976
uniprot id: A0A452FZT9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:PSMD7
gene id: 9925:PSMD7
uniprot id: A0A452F550
names: Similarity
messages: Belongs to the peptidase M67A family.

9925:ISL2
gene id: 9925:ISL2
uniprot id: A0A452ER63
names: Subcellular Location Annotation
messages: Nucleus

9925:APOPT1
gene id: 9925:APOPT1
uniprot id: A0A452FX23
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COA8 family.
messages: Mitochondrion inner membrane

9925:NDUFB3
gene id: 9925:NDUFB3
uniprot id: A0A452FQM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB3 subunit family.
messages: Mitochondrion inner membrane

9925:MALSU1
gene id: 9925:MALSU1
uniprot id: A0A452FT39
names: Similarity
messages: Belongs to the Iojap/RsfS family.

9925:LOC102178679
gene id: 9925:LOC102178679
uniprot id: A0A452ELU5
names: Similarity
messages: Belongs to the serpin family.

9925:DRC1
gene id: 9925:DRC1
uniprot id: A0A452DN57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DRC1 family.
messages: cilium axoneme
messages: flagellum axoneme

9925:KRT1
gene id: 9925:KRT1
uniprot id: A0A452GA47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane

9925:CSRNP2
gene id: 9925:CSRNP2
uniprot id: A0A452EZ71
uniprot id: A0A8C2N646
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9925:DEDD
gene id: 9925:DEDD
uniprot id: A0A452G415
names: Subcellular Location Annotation
messages: nucleolus

9925:TMEM33
gene id: 9925:TMEM33
uniprot id: A0A452G7T9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PER33/POM33 family.
messages: Membrane

9925:METTL6
gene id: 9925:METTL6
uniprot id: A0A452FI74
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9925:TMEM63B
gene id: 9925:TMEM63B
uniprot id: A0A452E391
uniprot id: A0A452E3D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9925:HS2ST1
gene id: 9925:HS2ST1
uniprot id: A0A452G6X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:ISCA2
gene id: 9925:ISCA2
uniprot id: A0A452DSX3
uniprot id: A0A8C2PDJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HesB/IscA family.
messages: Mitochondrion

9925:AAR2
gene id: 9925:AAR2
uniprot id: A0A452FHW4
names: Function
names: Similarity
messages: Belongs to the AAR2 family.
messages: Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing.

9925:FOXD1
gene id: 9925:FOXD1
uniprot id: A0A452DN80
names: Subcellular Location Annotation
messages: Nucleus

9925:KIAA1147
gene id: 9925:KIAA1147
uniprot id: A0A452ES34
names: Similarity
messages: Belongs to the DENND11 family.

9925:ELL2
gene id: 9925:ELL2
uniprot id: A0A452DXN8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9925:LIPM
gene id: 9925:LIPM
uniprot id: A0A452FDG0
uniprot id: A0A452FDG9
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9925:VSX1
gene id: 9925:VSX1
uniprot id: A0A452FQL4
names: Subcellular Location Annotation
messages: Nucleus

9925:EFEMP1
gene id: 9925:EFEMP1
uniprot id: A0A452FHB5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:DCAF13
gene id: 9925:DCAF13
uniprot id: A0A452FEI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat DCAF13/WDSOF1 family.
messages: nucleolus

9925:FAM124B
gene id: 9925:FAM124B
uniprot id: A0A452DSR2
names: Similarity
messages: Belongs to the FAM124 family.

9925:PRF1
gene id: 9925:PRF1
uniprot id: A0A452DK36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Secreted

9925:TNFRSF19
gene id: 9925:TNFRSF19
uniprot id: A0A452FKU7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:OGN
gene id: 9925:OGN
uniprot id: A0A452EV37
uniprot id: A1YZ35
names: Similarity
messages: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.

9925:CD93
gene id: 9925:CD93
uniprot id: A0A452DZ60
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102181052
gene id: 9925:LOC102181052
uniprot id: A0A452FWM8
uniprot id: A0A452FXE2
names: Similarity
messages: Belongs to the SELO family.

9925:TM9SF1
gene id: 9925:TM9SF1
uniprot id: A0A452FHN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9925:CNEP1R1
gene id: 9925:CNEP1R1
uniprot id: A0A452FKZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNEP1R1 family.
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane

9925:KCNV1
gene id: 9925:KCNV1
uniprot id: A0A452FUG1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.
messages: Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.
messages: Membrane
messages: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes.

9925:LOC102191157
gene id: 9925:LOC102191157
uniprot id: A0A452DXA1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CDKN2AIP
gene id: 9925:CDKN2AIP
uniprot id: A0A452FHG4
names: Similarity
messages: Belongs to the CARF family.

9925:CLN5
gene id: 9925:CLN5
uniprot id: A0A452FXM8
names: Similarity
messages: Belongs to the CLN5 family.

9925:FAM188A
gene id: 9925:FAM188A
uniprot id: A0A452E951
uniprot id: A0A452E9K8
names: Function
names: Similarity
messages: Belongs to the MINDY deubiquitinase family. FAM188 subfamily.
messages: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

9925:LOC102188409
gene id: 9925:LOC102188409
uniprot id: A0A452E805
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ZNF174
gene id: 9925:ZNF174
uniprot id: A0A452E9W1
names: Subcellular Location Annotation
messages: Nucleus

9925:GPN3
gene id: 9925:GPN3
uniprot id: A0A452EIF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GPN-loop GTPase family.
messages: Binds to RNA polymerase II (RNAPII).
messages: Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
messages: Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.

9925:JAKMIP1
gene id: 9925:JAKMIP1
uniprot id: A0A452FPE9
names: Similarity
messages: Belongs to the JAKMIP family.

9925:FKTN
gene id: 9925:FKTN
uniprot id: A0A452DZJ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LicD transferase family.
messages: Golgi apparatus membrane

9925:LOC102171189
gene id: 9925:LOC102171189
uniprot id: A0A452DTE0
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.

9925:PAX5
gene id: 9925:PAX5
uniprot id: A0A452F3C5
uniprot id: A0A8C2QZ02
names: Subcellular Location Annotation
messages: Nucleus

9925:TMEM192
gene id: 9925:TMEM192
uniprot id: A0A452G2F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM192 family.
messages: Late endosome
messages: Lysosome membrane
messages: Membrane

9925:SLC6A1
gene id: 9925:SLC6A1
uniprot id: A0A452EBY6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9925:FAM83F
gene id: 9925:FAM83F
uniprot id: A0A452G5M7
names: Similarity
messages: Belongs to the FAM83 family.

9925:IREB2
gene id: 9925:IREB2
uniprot id: A0A452FRW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Cytoplasm

9925:LOC106502530
gene id: 9925:LOC106502530
uniprot id: A0A452E369
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9925:RFX3
gene id: 9925:RFX3
uniprot id: A0A452E8U8
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102188268
gene id: 9925:LOC102188268
uniprot id: A0A452EIE8
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9925:LGI4
gene id: 9925:LGI4
uniprot id: A0A452DRW0
names: Subcellular Location Annotation
messages: Secreted

9925:LOC102186381
gene id: 9925:LOC102186381
uniprot id: A0A452EFS9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL34 family.

9925:LPAR6
gene id: 9925:LPAR6
uniprot id: A0A452FA83
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:PFKFB3
gene id: 9925:PFKFB3
uniprot id: A0A452FTG2
uniprot id: A0A452FTI6
uniprot id: A0A452FTP2
uniprot id: A0A8C2R0E2
names: Similarity
messages: In the C-terminal section; belongs to the phosphoglycerate mutase family.

9925:AHCYL1
gene id: 9925:AHCYL1
uniprot id: A0A452FSG9
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

9925:CNTF
gene id: 9925:CNTF
uniprot id: A0A452E586
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNTF family.
messages: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
messages: Cytoplasm

9925:AGRP
gene id: 9925:AGRP
uniprot id: A0A452G574
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:ARID5B
gene id: 9925:ARID5B
uniprot id: A0A452F8Y8
names: Similarity
messages: Belongs to the ARID5B family.

9925:TMEM132E
gene id: 9925:TMEM132E
uniprot id: A0A452ERS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM132 family.
messages: Membrane

9925:LOC102177258
gene id: 9925:LOC102177258
uniprot id: A0A452E455
names: Function
messages: Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle.

9925:ANKZF1
gene id: 9925:ANKZF1
uniprot id: A0A452FQ20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ANKZF1/VMS1 family.
messages: Cytoplasm

9925:TBC1D31
gene id: 9925:TBC1D31
uniprot id: A0A452EBQ0
uniprot id: A0A452EBQ6
names: Function
names: Subcellular Location Annotation
messages: Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation.
messages: centriolar satellite
messages: cilium basal body

9925:LOC102185520
gene id: 9925:LOC102185520
uniprot id: A0A452DPH6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102179574
gene id: 9925:LOC102179574
uniprot id: A0A452F9J7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9925:DPT
gene id: 9925:DPT
uniprot id: A0A452ELL8
names: Similarity
messages: Belongs to the dermatopontin family.

9925:TXNL4A
gene id: 9925:TXNL4A
uniprot id: A0A452F8N1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9925:C6H4orf48
gene id: 9925:C6H4orf48
uniprot id: A0A452DN45
names: Subcellular Location Annotation
messages: Secreted

9925:SLC17A7
gene id: 9925:SLC17A7
uniprot id: A0A452EXG8
names: Subcellular Location Annotation
messages: Membrane

9925:PRKCH
gene id: 9925:PRKCH
uniprot id: A0A452EXK6
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis.
messages: Cytoplasm
messages: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation.

9925:PLPPR2
gene id: 9925:PLPPR2
uniprot id: A0A452DXW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9925:LOC102174398
gene id: 9925:LOC102174398
uniprot id: A0A452E5F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9925:EXOC3L1
gene id: 9925:EXOC3L1
uniprot id: A0A452FZ30
names: Similarity
messages: Belongs to the SEC6 family.

9925:SMARCD1
gene id: 9925:SMARCD1
uniprot id: A0A452EUX3
names: Similarity
messages: Belongs to the SMARCD family.

9925:ZNF598
gene id: 9925:ZNF598
uniprot id: A0A452EED0
names: Similarity
messages: Belongs to the ZNF598/HEL2 family.

9925:NRXN2
gene id: 9925:NRXN2
uniprot id: A0A452FEU4
uniprot id: A0A452FF79
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:PLK1
gene id: 9925:PLK1
uniprot id: A0A452FQM0
names: Similarity
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.

9925:GSR
gene id: 9925:GSR
uniprot id: A0A452EXH1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Cytoplasm
messages: Maintains high levels of reduced glutathione in the cytosol.

9925:GNG5
gene id: 9925:GNG5
uniprot id: A0A452ETY3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9925:PER3
gene id: 9925:PER3
uniprot id: A0A452FMZ6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:LOC102191193
gene id: 9925:LOC102191193
uniprot id: A0A452E6M4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:KEF96 p07
gene id: 9925:KEF96_p07
uniprot id: E0XJW7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 3 family.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9925:CAV2
gene id: 9925:CAV2
uniprot id: A0A452EF60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

9925:MRPL22
gene id: 9925:MRPL22
uniprot id: A0A452FEU0
names: Similarity
messages: Belongs to the universal ribosomal protein uL22 family.

9925:FOXJ2
gene id: 9925:FOXJ2
uniprot id: A0A452FFQ9
names: Subcellular Location Annotation
messages: Nucleus

9925:MAPK13
gene id: 9925:MAPK13
uniprot id: A0A452FU55
names: Similarity
names: Subunit
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
messages: Interacts with MAPK8IP2.

9925:ANKRD13A
gene id: 9925:ANKRD13A
uniprot id: A0A452FKY4
names: Function
names: Subcellular Location Annotation
messages: Endosome
messages: Late endosome
messages: Membrane
messages: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane.

9925:RHBDD1
gene id: 9925:RHBDD1
uniprot id: A0A452F446
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102181105
gene id: 9925:LOC102181105
uniprot id: A0A452ESX1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9925:B4GAT1
gene id: 9925:B4GAT1
uniprot id: A0A452EHU1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 49 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:PALMD
gene id: 9925:PALMD
uniprot id: A0A452G5M5
names: Similarity
messages: Belongs to the paralemmin family.

9925:PNPO
gene id: 9925:PNPO
uniprot id: A0A452DR09
names: Function
names: Similarity
messages: Belongs to the pyridoxamine 5'-phosphate oxidase family.
messages: Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).

9925:MON2
gene id: 9925:MON2
uniprot id: A0A452DX07
names: Similarity
messages: Belongs to the MON2 family.

9925:LOC102171408
gene id: 9925:LOC102171408
uniprot id: A0A452DSB8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ZAR1L
gene id: 9925:ZAR1L
uniprot id: A0A452ECI3
names: Similarity
names: Subunit
messages: Belongs to the ZAR1 family.
messages: Interacts with YBX2.

9925:LOC102181961
gene id: 9925:LOC102181961
uniprot id: A0A8C2NY99
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:GNPNAT1
gene id: 9925:GNPNAT1
uniprot id: A0A452FFF1
names: Similarity
names: Subunit
messages: Belongs to the acetyltransferase family. GNA1 subfamily.
messages: Homodimer.

9925:NDUFA8
gene id: 9925:NDUFA8
uniprot id: A0A452FT17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9925:PTOV1
gene id: 9925:PTOV1
uniprot id: A0A452E261
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activates transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation.
messages: Belongs to the Mediator complex subunit 25 family. PTOV1 subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: May interact with CREBBP. Interacts with FLOT1.
messages: Nucleus
messages: perinuclear region

9925:LOC102183280
gene id: 9925:LOC102183280
uniprot id: A0A452E1V4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:KCNN4
gene id: 9925:KCNN4
uniprot id: A0A452F380
names: Subcellular Location Annotation
messages: Membrane

9925:SRD5A1
gene id: 9925:SRD5A1
uniprot id: A0A452EAN1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the steroid 5-alpha reductase family.
messages: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
messages: Membrane
messages: Microsome membrane

9925:EXOG
gene id: 9925:EXOG
uniprot id: A0A452EGM5
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

9925:FOLR1
gene id: 9925:FOLR1
uniprot id: A0A452FHW0
names: Similarity
messages: Belongs to the folate receptor family.

9925:LOC102177672
gene id: 9925:LOC102177672
uniprot id: A0A452G1F9
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:LOC102169350
gene id: 9925:LOC102169350
uniprot id: A0A452G3A4
names: Similarity
messages: Belongs to the glycosyl hydrolase 13 family.

9925:PTH2R
gene id: 9925:PTH2R
uniprot id: A0A452DQB4
names: Subcellular Location Annotation
messages: Membrane

9925:S100A11
gene id: 9925:S100A11
uniprot id: A0A452DZE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the S-100 family.
messages: Facilitates the differentiation and the cornification of keratinocytes.
messages: Homodimer; disulfide-linked.

9925:PI4K2B
gene id: 9925:PI4K2B
uniprot id: A0A452FNS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
messages: Membrane

9925:CSNK1A1
gene id: 9925:CSNK1A1
uniprot id: A0A452EE29
uniprot id: A0A452EEA1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:PPP1CB
gene id: 9925:PPP1CB
uniprot id: A0A452EJ96
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: nucleolus
messages: nucleoplasm

9925:FICD
gene id: 9925:FICD
uniprot id: A0A452ESE4
names: Similarity
messages: Belongs to the fic family.

9925:KCNT2
gene id: 9925:KCNT2
uniprot id: A0A452EQC9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:TERF2
gene id: 9925:TERF2
uniprot id: A0A452FZ10
names: Subcellular Location Annotation
messages: telomere

9925:LOC102179036
gene id: 9925:LOC102179036
uniprot id: A0A452FRZ3
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

9925:BEST1
gene id: 9925:BEST1
uniprot id: A0A452DRR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anion channel-forming bestrophin (TC 1.A.46) family. Calcium-sensitive chloride channel subfamily.
messages: Cell membrane
messages: Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
messages: Membrane

9925:DOK4
gene id: 9925:DOK4
uniprot id: A0A452G041
uniprot id: A0A8C2PL58
names: Similarity
messages: Belongs to the DOK family. Type B subfamily.

9925:ACAD9
gene id: 9925:ACAD9
uniprot id: A0A452FFQ6
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9925:CCT5
gene id: 9925:CCT5
uniprot id: A0A452F3U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9925:PTPRB
gene id: 9925:PTPRB
uniprot id: A0A452F427
uniprot id: A0A452F454
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

9925:C7H19orf70
gene id: 9925:C7H19orf70
uniprot id: A0A452G0R1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic13 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Membrane
messages: Mitochondrion inner membrane

9925:LOC108637952
gene id: 9925:LOC108637952
uniprot id: A0A452EYJ1
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

9925:UNC50
gene id: 9925:UNC50
uniprot id: A0A452EJH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the unc-50 family.
messages: Membrane
messages: Nucleus inner membrane

9925:AFP
gene id: 9925:AFP
uniprot id: A0A452DWC9
names: Subcellular Location Annotation
messages: Secreted

9925:CNRIP1
gene id: 9925:CNRIP1
uniprot id: A0A452EYK4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CNRIP family.
messages: Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.
messages: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.

9925:LOC102185617
gene id: 9925:LOC102185617
uniprot id: A0A452E490
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9925:EREG
gene id: 9925:EREG
uniprot id: A0A452DLR7
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:DHODH
gene id: 9925:DHODH
uniprot id: A0A452DLT1
uniprot id: A0A452DLT9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.
messages: Mitochondrion inner membrane

9925:STOML1
gene id: 9925:STOML1
uniprot id: A0A452FF35
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9925:LOC102183165
gene id: 9925:LOC102183165
uniprot id: A0A452DVB5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SUB1
gene id: 9925:SUB1
uniprot id: A0A452DX93
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional coactivator PC4 family.
messages: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
messages: Homodimer. Interacts with CSTF2.
messages: Nucleus

9925:RARS
gene id: 9925:RARS
uniprot id: A0A452FHC1
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9925:COMTD1
gene id: 9925:COMTD1
uniprot id: A0A452DRF4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.

9925:MYOD1
gene id: 9925:MYOD1
uniprot id: I7BWT2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.
messages: Nucleus

9925:GFOD1
gene id: 9925:GFOD1
uniprot id: A0A8C2S0B0
names: Similarity
messages: Belongs to the Gfo/Idh/MocA family.

9925:PSD2
gene id: 9925:PSD2
uniprot id: A0A452ENF5
names: Subcellular Location Annotation
messages: Membrane
messages: ruffle membrane

9925:LIN7C
gene id: 9925:LIN7C
uniprot id: A0A8C2NVT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9925:HTR5A
gene id: 9925:HTR5A
uniprot id: A0A452E9I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:ACAT2
gene id: 9925:ACAT2
uniprot id: A0A452F099
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9925:LOC108633800
gene id: 9925:LOC108633800
uniprot id: A0A452DMI4
names: Similarity
messages: Belongs to the cornifin (SPRR) family.

9925:SLC5A8
gene id: 9925:SLC5A8
uniprot id: A0A452EES5
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9925:RPL18A
gene id: 9925:RPL18A
uniprot id: A0A452G3Q2
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL20 family.

9925:RGMB
gene id: 9925:RGMB
uniprot id: A0A452FNF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the repulsive guidance molecule (RGM) family.
messages: Cell membrane
messages: Membrane

9925:MIOX
gene id: 9925:MIOX
uniprot id: A0A452FJR2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the myo-inositol oxygenase family.
messages: Binds 2 iron ions per subunit.
messages: Cytoplasm

9925:THTPA
gene id: 9925:THTPA
uniprot id: A0A452F7U1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ThTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Hydrolase highly specific for thiamine triphosphate (ThTP).
messages: Monomer.

9925:ELOVL1
gene id: 9925:ELOVL1
uniprot id: A0A452E079
uniprot id: V5N403
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ELO family. ELOVL1 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.
messages: Endoplasmic reticulum membrane
messages: Interacts with LASS2, TECR and HSD17B12.
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9925:GOLPH3L
gene id: 9925:GOLPH3L
uniprot id: A0A452F2Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLPH3/VPS74 family.
messages: Golgi stack membrane
messages: Membrane
messages: trans-Golgi network membrane

9925:ANXA4
gene id: 9925:ANXA4
uniprot id: A0A452G9Y2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Zymogen granule membrane

9925:FGF1
gene id: 9925:FGF1
uniprot id: A0A142I1Y1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heparin-binding growth factors family.
messages: Cytoplasm
messages: Nucleus
messages: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.
messages: Secreted
messages: cell cortex
messages: cytosol

9925:NDUFB7
gene id: 9925:NDUFB7
uniprot id: A0A452EGT0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB7 subunit family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9925:ENO1
gene id: 9925:ENO1
uniprot id: A0A452EU55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Cytoplasm

9925:CTSL
gene id: 9925:CTSL
uniprot id: A0A452FFI6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9925:RPS5
gene id: 9925:RPS5
uniprot id: A0A452F9Y6
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9925:VWC2
gene id: 9925:VWC2
uniprot id: A0A452FG22
names: Subcellular Location Annotation
messages: Synapse

9925:CDH5
gene id: 9925:CDH5
uniprot id: A0A452EQV9
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9925:ARF4
gene id: 9925:ARF4
uniprot id: A0A452DS03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9925:GNPTAB
gene id: 9925:GNPTAB
uniprot id: A0A452FWU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the stealth family.
messages: Membrane

9925:STAT4
gene id: 9925:STAT4
uniprot id: A0A452FGT3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9925:LOC102186918
gene id: 9925:LOC102186918
uniprot id: A0A452EC18
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone H1/H5 family.
messages: Nucleus

9925:STK38
gene id: 9925:STK38
uniprot id: A0A452E4G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily.
messages: Cytoplasm

9925:ATP10B
gene id: 9925:ATP10B
uniprot id: A0A452FXB6
uniprot id: A0A452FYC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9925:PARP16
gene id: 9925:PARP16
uniprot id: A0A452E9F8
names: Similarity
messages: Belongs to the ARTD/PARP family.

9925:STX7
gene id: 9925:STX7
uniprot id: A0A452ENI2
names: Similarity
messages: Belongs to the syntaxin family.

9925:POU2F1
gene id: 9925:POU2F1
uniprot id: A0A452G945
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus
messages: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.

9925:METTL11B
gene id: 9925:METTL11B
uniprot id: A0A452DVJ8
names: Similarity
messages: Belongs to the methyltransferase superfamily. NTM1 family.

9925:TBCD
gene id: 9925:TBCD
uniprot id: A0A452FBF4
uniprot id: A0A452FC13
names: Similarity
messages: Belongs to the TBCD family.

9925:TNFRSF9
gene id: 9925:TNFRSF9
uniprot id: A0A452E393
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102180368
gene id: 9925:LOC102180368
uniprot id: A0A452FIN7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9925:PEX19
gene id: 9925:PEX19
uniprot id: A0A452EGH5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxin-19 family.
messages: Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.
messages: Membrane
messages: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.
messages: Peroxisome membrane

9925:GOSR2
gene id: 9925:GOSR2
uniprot id: A0A452ET48
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOSR2 family.
messages: Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
messages: Membrane

9925:NMU
gene id: 9925:NMU
uniprot id: A0A452EDD1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NmU family.
messages: Secreted

9925:FMO1
gene id: 9925:FMO1
uniprot id: A0A452E6M3
uniprot id: A0A452E6N7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:SDHAF2
gene id: 9925:SDHAF2
uniprot id: A0A452FSY4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SDHAF2 family.
messages: Interacts with SDHA within the SDH catalytic dimer.
messages: Mitochondrion matrix
messages: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.

9925:MEX3C
gene id: 9925:MEX3C
uniprot id: A0A452F2V3
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:TM9SF3
gene id: 9925:TM9SF3
uniprot id: A0A452EBK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9925:SESN2
gene id: 9925:SESN2
uniprot id: A0A452FUJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sestrin family.
messages: Cytoplasm

9925:ANAPC16
gene id: 9925:ANAPC16
uniprot id: A0A452EUZ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APC16 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
messages: Cytoplasm
messages: Nucleus
messages: kinetochore

9925:SEPT8
gene id: 9925:SEPT8
uniprot id: A0A452EJB8
uniprot id: A0A452EK25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9925:ATP5G1
gene id: 9925:ATP5G1
uniprot id: A0A452EXR7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
messages: Mitochondrion membrane

9925:UFM1
gene id: 9925:UFM1
uniprot id: A0A452EEH0
names: Function
names: Similarity
messages: Belongs to the UFM1 family.
messages: Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.

9925:LOC108633342
gene id: 9925:LOC108633342
uniprot id: A0A452EDE6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:SLC25A44
gene id: 9925:SLC25A44
uniprot id: A0A452E8C8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:LCAT
gene id: 9925:LCAT
uniprot id: A0A452EJ90
names: Similarity
messages: Belongs to the AB hydrolase superfamily. Lipase family.

9925:FOXR1
gene id: 9925:FOXR1
uniprot id: A0A452F8Q4
names: Subcellular Location Annotation
messages: Nucleus

9925:KCNC4
gene id: 9925:KCNC4
uniprot id: A0A452FPH3
uniprot id: A0A452FPQ5
names: Subcellular Location Annotation
messages: Membrane

9925:SSH3
gene id: 9925:SSH3
uniprot id: A0A8C2RR13
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family.

9925:KCNJ1
gene id: 9925:KCNJ1
uniprot id: A0A8C2PAN6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9925:KIAA0907
gene id: 9925:KIAA0907
uniprot id: A0A452FRD1
names: Similarity
messages: Belongs to the KHDC4 family.

9925:KIFC3
gene id: 9925:KIFC3
uniprot id: A0A452FWX8
uniprot id: A0A452FX82
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9925:YWHAH
gene id: 9925:YWHAH
uniprot id: A0A452EU44
names: Similarity
messages: Belongs to the 14-3-3 family.

9925:NME5
gene id: 9925:NME5
uniprot id: A0A452EME5
names: Similarity
messages: Belongs to the NDK family.

9925:SPTBN1
gene id: 9925:SPTBN1
uniprot id: A0A452ENG9
uniprot id: A0A452EPK3
names: Similarity
messages: Belongs to the spectrin family.

9925:CORO1C
gene id: 9925:CORO1C
uniprot id: A0A452FNA0
names: Similarity
messages: Belongs to the WD repeat coronin family.

9925:CPEB2
gene id: 9925:CPEB2
uniprot id: A0A452FP70
uniprot id: A0A452FPA2
names: Similarity
messages: Belongs to the RRM CPEB family.

9925:CES2
gene id: 9925:CES2
uniprot id: A0A452F9A7
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

9925:ATP6V0C
gene id: 9925:ATP6V0C
uniprot id: A0A452FRS6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Membrane
messages: Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.
messages: Vacuole membrane
messages: clathrin-coated vesicle membrane
messages: synaptic vesicle membrane

9925:PLRG1
gene id: 9925:PLRG1
uniprot id: A0A452EJH1
names: Similarity
messages: Belongs to the WD repeat PRL1/PRL2 family.

9925:DIO2
gene id: 9925:DIO2
uniprot id: A0A452EKG0
names: Function
names: Similarity
messages: Belongs to the iodothyronine deiodinase family.
messages: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine).

9925:GPR37
gene id: 9925:GPR37
uniprot id: A0A452FEC9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:TUBD1
gene id: 9925:TUBD1
uniprot id: A0A452F1L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tubulin family.
messages: Nucleus
messages: centriole
messages: cilium

9925:DNASE1L3
gene id: 9925:DNASE1L3
uniprot id: A0A452FMP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNase I family.
messages: Nucleus envelope
messages: Zymogen granule

9925:CHST8
gene id: 9925:CHST8
uniprot id: A0A452FA40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:FOXP1
gene id: 9925:FOXP1
uniprot id: A0A452F1P1
names: Subcellular Location Annotation
messages: Nucleus

9925:GUCY2C
gene id: 9925:GUCY2C
uniprot id: A0A452E1V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Membrane

9925:LOC102188430
gene id: 9925:LOC102188430
uniprot id: A0A452E2H2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:VAT1L
gene id: 9925:VAT1L
uniprot id: A0A452G3P6
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

9925:LOC102181382
gene id: 9925:LOC102181382
uniprot id: A0A452ECM5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9925:LOC102187205
gene id: 9925:LOC102187205
uniprot id: A0A452DQQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:DPEP3
gene id: 9925:DPEP3
uniprot id: A0A452G4L4
names: Subcellular Location Annotation
messages: Membrane

9925:DUSP26
gene id: 9925:DUSP26
uniprot id: A0A8C2PFI5
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9925:LOC102185233
gene id: 9925:LOC102185233
uniprot id: A0A452DV45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TCP1
gene id: 9925:TCP1
uniprot id: A0A452EVX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: centrosome

9925:WNT8B
gene id: 9925:WNT8B
uniprot id: A0A8C2RUY4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9925:GGNBP2
gene id: 9925:GGNBP2
uniprot id: A0A452F422
uniprot id: A0A452F482
uniprot id: A0A8C2RQ66
uniprot id: A0A8C2RT53
names: Function
messages: May be involved in spermatogenesis.

9925:SKIL
gene id: 9925:SKIL
uniprot id: A0A452DY18
names: Similarity
messages: Belongs to the SKI family.

9925:MTMR7
gene id: 9925:MTMR7
uniprot id: A0A452DQI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
messages: Cytoplasm

9925:RRM1
gene id: 9925:RRM1
uniprot id: A0A452F6S5
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

9925:LOC102190774
gene id: 9925:LOC102190774
uniprot id: A0A452DW50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:STARD13
gene id: 9925:STARD13
uniprot id: A0A452FJE7
uniprot id: A0A452FJG1
names: Subcellular Location Annotation
messages: Cytoplasm

9925:IRGC
gene id: 9925:IRGC
uniprot id: A0A452DV87
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.

9925:GRIN3A
gene id: 9925:GRIN3A
uniprot id: A0A452G736
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.

9925:GMPR
gene id: 9925:GMPR
uniprot id: A0A8C2Y192
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
messages: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
messages: Homotetramer.

9925:NKX6-1
gene id: 9925:NKX6-1
uniprot id: A0A452FUR1
names: Subcellular Location Annotation
messages: Nucleus

9925:CPSF6
gene id: 9925:CPSF6
uniprot id: A0A452E5B8
uniprot id: A0A452E5C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Nucleus

9925:SH3RF1
gene id: 9925:SH3RF1
uniprot id: A0A452FSX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SH3RF family.
messages: lamellipodium
messages: perinuclear region
messages: trans-Golgi network

9925:LOC102174337
gene id: 9925:LOC102174337
uniprot id: A0A452DUS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CAPN5
gene id: 9925:CAPN5
uniprot id: A0A452E1M5
names: Similarity
messages: Belongs to the peptidase C2 family.

9925:SEMA4C
gene id: 9925:SEMA4C
uniprot id: A0A452F0G1
uniprot id: A0A8C2P0U8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:ACTG2
gene id: 9925:ACTG2
uniprot id: A0A452DZK4
uniprot id: A0A8C2RJE3
names: Similarity
messages: Belongs to the actin family.

9925:LOC102189444
gene id: 9925:LOC102189444
uniprot id: A0A452E492
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9925:DHDDS
gene id: 9925:DHDDS
uniprot id: A0A452EDZ8
names: Similarity
messages: Belongs to the UPP synthase family.

9925:LOC102174710
gene id: 9925:LOC102174710
uniprot id: A0A452E470
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:LOC102179792
gene id: 9925:LOC102179792
uniprot id: A0A452DXH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:XYLB
gene id: 9925:XYLB
uniprot id: A0A452FYS1
names: Function
names: Similarity
messages: Belongs to the FGGY kinase family.
messages: Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis.

9925:PCYOX1L
gene id: 9925:PCYOX1L
uniprot id: A0A452FR45
names: Similarity
messages: Belongs to the prenylcysteine oxidase family.

9925:FABP7
gene id: 9925:FABP7
uniprot id: A0A452FX97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9925:PTGER2
gene id: 9925:PTGER2
uniprot id: J7JZC4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:TNFSF4
gene id: 9925:TNFSF4
uniprot id: A0A452FAW5
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9925:ATP6V1G2
gene id: 9925:ATP6V1G2
uniprot id: A0A452FY25
names: Function
names: Similarity
names: Subunit
messages: Belongs to the V-ATPase G subunit family.
messages: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.

9925:SPC24
gene id: 9925:SPC24
uniprot id: A0A452FIW5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the SPC24 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9925:LOC102185247
gene id: 9925:LOC102185247
uniprot id: A0A452E5U7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SDC3
gene id: 9925:SDC3
uniprot id: A0A452ERE2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syndecan proteoglycan family.
messages: Cell surface proteoglycan.
messages: Membrane

9925:ATG4D
gene id: 9925:ATG4D
uniprot id: A0A452F1U2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C54 family.
messages: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.
messages: Cytoplasm

9925:LOC102171511
gene id: 9925:LOC102171511
uniprot id: A0A452DV98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CDC20
gene id: 9925:CDC20
uniprot id: A0A452FC83
names: Similarity
messages: Belongs to the WD repeat CDC20/Fizzy family.

9925:RSRP1
gene id: 9925:RSRP1
uniprot id: A0A452ER76
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RSRP family.
messages: Nucleus
messages: Probably acts as a spliceosomal factor that contributes to spliceosome assembly and regulates the isoform switching of proteins such as PARP6.

9925:OLFM3
gene id: 9925:OLFM3
uniprot id: A0A452DWG8
uniprot id: A0A452DWI0
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9925:LOC102185401
gene id: 9925:LOC102185401
uniprot id: A0A452FJ07
names: Similarity
messages: Belongs to the serpin family.

9925:NGB
gene id: 9925:NGB
uniprot id: A0A452F441
names: Similarity
messages: Belongs to the globin family.

9925:LOC102174373
gene id: 9925:LOC102174373
uniprot id: A0A452G189
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. NDST subfamily.
messages: Membrane

9925:LOC102179595
gene id: 9925:LOC102179595
uniprot id: A0A452DQ89
names: Function
messages: The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulfur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa).

9925:CPA6
gene id: 9925:CPA6
uniprot id: A0A452FS08
names: Similarity
messages: Belongs to the peptidase M14 family.

9925:BMP7
gene id: 9925:BMP7
uniprot id: A0A452E223
names: Similarity
messages: Belongs to the TGF-beta family.

9925:LOC102179294
gene id: 9925:LOC102179294
uniprot id: A0A8C2NVG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Lipocalin family.
messages: Secreted

9925:LTBR
gene id: 9925:LTBR
uniprot id: I6SMD9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102175243
gene id: 9925:LOC102175243
uniprot id: A0A452DT72
names: Similarity
messages: Belongs to the histone H2B family.

9925:ACO2
gene id: 9925:ACO2
uniprot id: A0A452DW73
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aconitase/IPM isomerase family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
messages: Mitochondrion

9925:LOC102185215
gene id: 9925:LOC102185215
uniprot id: A0A452DQV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:EEF2KMT
gene id: 9925:EEF2KMT
uniprot id: A0A452EPV4
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.

9925:MMS22L
gene id: 9925:MMS22L
uniprot id: A0A452F999
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MMS22 family. MMS22L subfamily.
messages: Chromosome
messages: Nucleus

9925:KRT23
gene id: 9925:KRT23
uniprot id: A0A452EF71
names: Similarity
messages: Belongs to the intermediate filament family.

9925:LMBR1
gene id: 9925:LMBR1
uniprot id: A0A452EMI4
names: Similarity
messages: Belongs to the LIMR family.

9925:ZDHHC1
gene id: 9925:ZDHHC1
uniprot id: A0A452E0P5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9925:LOXL3
gene id: 9925:LOXL3
uniprot id: A0A452FS61
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lysyl oxidase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
messages: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
messages: extracellular space

9925:NAA25
gene id: 9925:NAA25
uniprot id: A0A452E523
names: Similarity
messages: Belongs to the MDM20/NAA25 family.

9925:GRK3
gene id: 9925:GRK3
uniprot id: A0A452FKL7
names: Similarity
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.

9925:XRN2
gene id: 9925:XRN2
uniprot id: A0A452DTJ8
names: Function
names: Similarity
messages: Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.
messages: Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.

9925:DLC1
gene id: 9925:DLC1
uniprot id: A0A452EWD2
uniprot id: A0A452EWF4
uniprot id: A0A452EWG7
names: Subcellular Location Annotation
messages: Cytoplasm

9925:SLC35C2
gene id: 9925:SLC35C2
uniprot id: A0A452EG32
names: Subcellular Location Annotation
messages: Membrane

9925:JAGN1
gene id: 9925:JAGN1
uniprot id: A0A452E9W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the jagunal family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:GJA5
gene id: 9925:GJA5
uniprot id: A0A452E514
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9925:LOC102184041
gene id: 9925:LOC102184041
uniprot id: A0A452ESD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GST superfamily. Pi family.
messages: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
messages: Cytoplasm
messages: Homodimer.
messages: Mitochondrion
messages: Nucleus

9925:LOC102183418
gene id: 9925:LOC102183418
uniprot id: A0A452DRM7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SLC9A3R2
gene id: 9925:SLC9A3R2
uniprot id: A0A452EVV7
uniprot id: A0A452EVW7
uniprot id: A0A8C2S760
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Endomembrane system
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.

9925:KCNK3
gene id: 9925:KCNK3
uniprot id: A0A452G8X9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9925:SLC7A2
gene id: 9925:SLC7A2
uniprot id: A0A452G3W3
uniprot id: A0A452G426
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.
messages: Cell membrane
messages: Membrane

9925:YOD1
gene id: 9925:YOD1
uniprot id: A0A452EJV7
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin.

9925:PDE1B
gene id: 9925:PDE1B
uniprot id: A0A452GAQ1
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9925:SKA1
gene id: 9925:SKA1
uniprot id: A0A452EMN7
names: Similarity
messages: Belongs to the SKA1 family.

9925:LIN7B
gene id: 9925:LIN7B
uniprot id: A0A452F746
uniprot id: A0A8C2XWC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the lin-7 family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane
messages: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.
messages: Postsynaptic density membrane
messages: tight junction

9925:SPPL2B
gene id: 9925:SPPL2B
uniprot id: A0A452F5Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Endosome membrane
messages: Lysosome membrane
messages: Membrane

9925:APLP1
gene id: 9925:APLP1
uniprot id: A0A8C2XWZ3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the APP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:MAPRE1
gene id: 9925:MAPRE1
uniprot id: A0A452FST7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

9925:SYT2
gene id: 9925:SYT2
uniprot id: A0A452FVH5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptotagmin family.
messages: Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.
messages: May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
messages: synaptic vesicle membrane

9925:ZFP36
gene id: 9925:ZFP36
uniprot id: A0A452FS29
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.
messages: Cytoplasm
messages: Nucleus
messages: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

9925:NDFIP2
gene id: 9925:NDFIP2
uniprot id: A0A452EF12
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9925:NR2E3
gene id: 9925:NR2E3
uniprot id: A0A452EMS2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9925:L3MBTL3
gene id: 9925:L3MBTL3
uniprot id: A0A452FR05
names: Subcellular Location Annotation
messages: Nucleus

9925:HOXC11
gene id: 9925:HOXC11
uniprot id: A0A452G1W3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9925:MGAT1
gene id: 9925:MGAT1
uniprot id: A0A452DZX1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
messages: Membrane
messages: The cofactor is mostly bound to the substrate.

9925:CDR2L
gene id: 9925:CDR2L
uniprot id: A0A452G4B2
names: Similarity
messages: Belongs to the CDR2 family.

9925:SEPT4
gene id: 9925:SEPT4
uniprot id: A0A452FZD4
uniprot id: A0A8C2PBJ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9925:YME1L1
gene id: 9925:YME1L1
uniprot id: A0A452G9W9
names: Similarity
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the N-terminal section; belongs to the AAA ATPase family.

9925:SRRT
gene id: 9925:SRRT
uniprot id: A0A452E486
names: Similarity
messages: Belongs to the ARS2 family.

9925:LOC102186455
gene id: 9925:LOC102186455
uniprot id: A0A452E852
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:CCNYL1
gene id: 9925:CCNYL1
uniprot id: A0A452E6C6
names: Similarity
messages: Belongs to the cyclin family. Cyclin Y subfamily.

9925:PTBP1
gene id: 9925:PTBP1
uniprot id: A0A452F421
uniprot id: A0A8C2S4N7
names: Subcellular Location Annotation
messages: Nucleus

9925:ARSG
gene id: 9925:ARSG
uniprot id: A0A452E4W0
names: Similarity
messages: Belongs to the sulfatase family.

9925:MRPL53
gene id: 9925:MRPL53
uniprot id: A0A452DZS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL53 family.
messages: Mitochondrion

9925:MAP3K5
gene id: 9925:MAP3K5
uniprot id: A0A452FWU2
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9925:STAM
gene id: 9925:STAM
uniprot id: A0A452DQV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STAM family.
messages: Early endosome membrane
messages: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

9925:LOC102177643
gene id: 9925:LOC102177643
uniprot id: A0A452E3V5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:DRAM1
gene id: 9925:DRAM1
uniprot id: A0A452FA53
names: Subcellular Location Annotation
messages: Membrane

9925:DAD1
gene id: 9925:DAD1
uniprot id: A0A452EZZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DAD/OST2 family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.

9925:HDAC2
gene id: 9925:HDAC2
uniprot id: A0A452FXL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the histone deacetylase family. HD Type 1 subfamily.
messages: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
messages: Nucleus

9925:OLFM4
gene id: 9925:OLFM4
uniprot id: A0A452EDJ3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102169897
gene id: 9925:LOC102169897
uniprot id: A0A452F3R0
names: Subcellular Location Annotation
messages: Membrane

9925:MIEF1
gene id: 9925:MIEF1
uniprot id: A0A452EZR9
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion outer membrane

9925:LOC102175358
gene id: 9925:LOC102175358
uniprot id: A0A452DQR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9925:CHRD
gene id: 9925:CHRD
uniprot id: A0A452E873
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chordin family.
messages: Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.
messages: Secreted

9925:LHPP
gene id: 9925:LHPP
uniprot id: A0A452EXK5
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

9925:SLC1A7
gene id: 9925:SLC1A7
uniprot id: A0A452FA57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9925:ELL3
gene id: 9925:ELL3
uniprot id: A0A452EPJ1
uniprot id: A0A8C2RAR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Nucleus

9925:CALHM2
gene id: 9925:CALHM2
uniprot id: A0A452EMK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9925:EIF2A
gene id: 9925:EIF2A
uniprot id: A0A452FUT9
names: Function
names: Similarity
messages: Belongs to the WD repeat EIF2A family.
messages: Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

9925:LOC102188157
gene id: 9925:LOC102188157
uniprot id: A0A452DXE3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SLC27A4
gene id: 9925:SLC27A4
uniprot id: A0A452G7M8
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9925:DDX41
gene id: 9925:DDX41
uniprot id: A0A452E157
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX41 subfamily.

9925:TMEM150C
gene id: 9925:TMEM150C
uniprot id: A0A452ECM4
names: Subcellular Location Annotation
messages: Membrane

9925:NUP62
gene id: 9925:NUP62
uniprot id: A0A452EAV8
names: Similarity
messages: Belongs to the nucleoporin NSP1/NUP62 family.

9925:LOC102175203
gene id: 9925:LOC102175203
uniprot id: A0A452DMS2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102183751
gene id: 9925:LOC102183751
uniprot id: A0A452FHX5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Mitochondrion intermembrane space
messages: Required for assembly of mitochondrial respiratory chain complexes.

9925:GNG4
gene id: 9925:GNG4
uniprot id: A0A452DL78
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9925:STARD3
gene id: 9925:STARD3
uniprot id: A0A452FD86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STARD3 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9925:HOXB6
gene id: 9925:HOXB6
uniprot id: A0A452DXW1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9925:LOC102178586
gene id: 9925:LOC102178586
uniprot id: A0A452DW09
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:TTC27
gene id: 9925:TTC27
uniprot id: A0A452F011
names: Similarity
messages: Belongs to the TTC27 family.

9925:LOC102184705
gene id: 9925:LOC102184705
uniprot id: A0A452DY73
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:STEAP4
gene id: 9925:STEAP4
uniprot id: A0A452DXA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9925:ZBED9
gene id: 9925:ZBED9
uniprot id: A0A452ENK9
names: Subcellular Location Annotation
messages: Nucleus

9925:SEZ6L2
gene id: 9925:SEZ6L2
uniprot id: A0A452FYW1
uniprot id: A0A452FZB4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:MMP2
gene id: 9925:MMP2
uniprot id: A0A452EUZ5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: extracellular matrix

9925:RNF5
gene id: 9925:RNF5
uniprot id: A0A8C2S9Q0
names: Domain
names: Function
names: Subcellular Location Annotation
messages: E3 ubiquitin-protein ligase.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion membrane
messages: The RING-type zinc finger domain is responsible for E3 ligase activity.

9925:RPS6KB1
gene id: 9925:RPS6KB1
uniprot id: D1MGL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
messages: Cytoplasm

9925:DLG1
gene id: 9925:DLG1
uniprot id: A0A452E2S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: Membrane

9925:MAPK6
gene id: 9925:MAPK6
uniprot id: A0A452G716
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

9925:NAA11
gene id: 9925:NAA11
uniprot id: A0A452E097
names: Similarity
messages: Belongs to the acetyltransferase family. ARD1 subfamily.

9925:KEF96 p09
gene id: 9925:KEF96_p09
uniprot id: D0VEF8
uniprot id: Q32643
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase protein 8 family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. Component of an ATP synthase complex composed of ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and ATP5MJ (By similarity). Interacts with PRICKLE3 (By similarity).
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion membrane

9925:ADAMTS14
gene id: 9925:ADAMTS14
uniprot id: A0A452EP21
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:LOC108637886
gene id: 9925:LOC108637886
uniprot id: A0A452DW17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

9925:LOC102190498
gene id: 9925:LOC102190498
uniprot id: A0A452EPL4
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9925:HSPB6
gene id: 9925:HSPB6
uniprot id: A0A452DU61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small heat shock protein (HSP20) family.
messages: Cytoplasm
messages: Nucleus

9925:GDI2
gene id: 9925:GDI2
uniprot id: A0A452G6V6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab GDI family.
messages: Cytoplasm
messages: Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.

9925:OXSR1
gene id: 9925:OXSR1
uniprot id: A0A452EZ97
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

9925:INSL6
gene id: 9925:INSL6
uniprot id: A0A452FEB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted

9925:ATRAID
gene id: 9925:ATRAID
uniprot id: A0A452ENK5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:VPS29
gene id: 9925:VPS29
uniprot id: A0A452DWY1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
messages: Belongs to the VPS29 family.
messages: Endosome membrane

9925:CNOT1
gene id: 9925:CNOT1
uniprot id: A0A452E3Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT1 family.
messages: Nucleus

9925:GRB2
gene id: 9925:GRB2
uniprot id: A0A452ET74
names: Subcellular Location Annotation
messages: Endosome
messages: Golgi apparatus
messages: Nucleus

9925:ULK3
gene id: 9925:ULK3
uniprot id: A0A452FTS1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:LACTB2
gene id: 9925:LACTB2
uniprot id: A0A452EAU9
names: Function
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.
messages: Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.

9925:OGG1
gene id: 9925:OGG1
uniprot id: A0A452FPR9
names: Function
names: Similarity
messages: Belongs to the type-1 OGG1 family.
messages: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

9925:TPK1
gene id: 9925:TPK1
uniprot id: A0A452EDU3
names: Similarity
messages: Belongs to the thiamine pyrophosphokinase family.

9925:LOC102173645
gene id: 9925:LOC102173645
uniprot id: A0A452E0Q4
names: Similarity
messages: Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

9925:SLC2A13
gene id: 9925:SLC2A13
uniprot id: A0A452FP08
names: Similarity
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

9925:RAB3GAP2
gene id: 9925:RAB3GAP2
uniprot id: A0A452ECW0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP regulatory subunit family.
messages: Cytoplasm

9925:PIGW
gene id: 9925:PIGW
uniprot id: A0A452EF75
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGW family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.

9925:ME3
gene id: 9925:ME3
uniprot id: A0A452EKF4
uniprot id: A0A452EKP7
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9925:DAPK3
gene id: 9925:DAPK3
uniprot id: A0A452F3E9
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:ABCA1
gene id: 9925:ABCA1
uniprot id: A0A452FX28
names: Subcellular Location Annotation
messages: Membrane

9925:CEP63
gene id: 9925:CEP63
uniprot id: A0A452G727
uniprot id: A0A452G796
names: Similarity
messages: Belongs to the CEP63 family.

9925:LOC102190876
gene id: 9925:LOC102190876
uniprot id: A0A452E1B9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

9925:LMNA
gene id: 9925:LMNA
uniprot id: A0A452FQ33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9925:LOC102178483
gene id: 9925:LOC102178483
uniprot id: G8FGA4
names: Function
messages: The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulfur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa).

9925:FAM193A
gene id: 9925:FAM193A
uniprot id: A0A452FPH5
names: Similarity
messages: Belongs to the FAM193 family.

9925:AGPAT2
gene id: 9925:AGPAT2
uniprot id: A0A452EMZ4
names: Domain
names: Function
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
messages: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
messages: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.

9925:LOC102180330
gene id: 9925:LOC102180330
uniprot id: A0A452F0P6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm
messages: May play a role in lipid transport protein in Schwann cells. May bind cholesterol.
messages: Monomer.

9925:LOC102191741
gene id: 9925:LOC102191741
uniprot id: A0A452E219
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase subunit 5A family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Mitochondrion inner membrane

9925:KIAA0430
gene id: 9925:KIAA0430
uniprot id: A0A452DXE6
names: Subcellular Location Annotation
messages: Peroxisome

9925:TP53INP1
gene id: 9925:TP53INP1
uniprot id: A0A452DZ02
uniprot id: A0A8C2RYD0
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

9925:SLC5A1
gene id: 9925:SLC5A1
uniprot id: V9I0K9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9925:RRH
gene id: 9925:RRH
uniprot id: A0A8C2P4U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9925:GBA2
gene id: 9925:GBA2
uniprot id: A0A452G1H9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the non-lysosomal glucosylceramidase family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.

9925:ACVR2B
gene id: 9925:ACVR2B
uniprot id: W8P9F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9925:SLC20A2
gene id: 9925:SLC20A2
uniprot id: A0A452FTH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Sodium-phosphate symporter.

9925:CHAC2
gene id: 9925:CHAC2
uniprot id: A0A452EWJ0
uniprot id: A0A452EWP6
names: Function
names: Similarity
messages: Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
messages: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

9925:TRIM10
gene id: 9925:TRIM10
uniprot id: A0A8C2PDL0
names: Subcellular Location Annotation
messages: Cytoplasm

9925:ABCG1
gene id: 9925:ABCG1
uniprot id: A0A452DUB9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
messages: Membrane

9925:LOC102187613
gene id: 9925:LOC102187613
uniprot id: A0A452EFW5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:POLR3B
gene id: 9925:POLR3B
uniprot id: A0A452ESS0
names: Function
names: Similarity
messages: Belongs to the RNA polymerase beta chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

9925:LOC102176524
gene id: 9925:LOC102176524
uniprot id: A0A452FKJ3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.
messages: Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:SLC30A4
gene id: 9925:SLC30A4
uniprot id: A0A452FFX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9925:PPRC1
gene id: 9925:PPRC1
uniprot id: A0A452E8L4
names: Subcellular Location Annotation
messages: Nucleus

9925:KCNJ5
gene id: 9925:KCNJ5
uniprot id: A0A452EDV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.
messages: Membrane

9925:PIGB
gene id: 9925:PIGB
uniprot id: A0A452F7F9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:SMARCA5
gene id: 9925:SMARCA5
uniprot id: A0A452EIB7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
messages: Nucleus

9925:SPAG9
gene id: 9925:SPAG9
uniprot id: A0A452FSH2
names: Similarity
messages: Belongs to the JIP scaffold family.

9925:MVB12B
gene id: 9925:MVB12B
uniprot id: A0A452EGG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MVB12 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9925:SH3GLB1
gene id: 9925:SH3GLB1
uniprot id: A0A452G8L4
uniprot id: A0A452G8S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Golgi apparatus membrane
messages: Midbody
messages: Mitochondrion outer membrane
messages: autophagosome membrane

9925:PLAU
gene id: 9925:PLAU
uniprot id: A0A452DLQ8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:SIX5
gene id: 9925:SIX5
uniprot id: A0A452FQ65
names: Subcellular Location Annotation
messages: Nucleus

9925:KCNA4
gene id: 9925:KCNA4
uniprot id: A0A452DMS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.
messages: Cell membrane
messages: Membrane
messages: axon

9925:KIAA1024
gene id: 9925:KIAA1024
uniprot id: A0A452G1T1
names: Similarity
messages: Belongs to the MINAR family.

9925:C11H2orf70
gene id: 9925:C11H2orf70
uniprot id: A0A452F0H4
names: Similarity
messages: Belongs to the CIMIP2 family.

9925:TSPAN33
gene id: 9925:TSPAN33
uniprot id: A0A452FH43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9925:ATXN1L
gene id: 9925:ATXN1L
uniprot id: A0A452E924
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

9925:RANGRF
gene id: 9925:RANGRF
uniprot id: A0A452G0E7
uniprot id: A0A8C2S790
names: Similarity
messages: Belongs to the MOG1 family.

9925:AGAP1
gene id: 9925:AGAP1
uniprot id: A0A452ERT0
uniprot id: A0A452ERZ7
names: Similarity
messages: Belongs to the centaurin gamma-like family.

9925:LOC102182812
gene id: 9925:LOC102182812
uniprot id: A0A452DWH5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:GCG
gene id: 9925:GCG
uniprot id: A0A452FHY7
names: Similarity
messages: Belongs to the glucagon family.

9925:VPS16
gene id: 9925:VPS16
uniprot id: A0A452E7D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS16 family.
messages: Early endosome
messages: Late endosome membrane
messages: Lysosome membrane
messages: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.
messages: Vesicle

9925:C7
gene id: 9925:C7
uniprot id: A0A452EW20
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complement C6/C7/C8/C9 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:ATL1
gene id: 9925:ATL1
uniprot id: A0A8C2NZ54
uniprot id: A0A8C2P178
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9925:ELOVL6
gene id: 9925:ELOVL6
uniprot id: A0A096ZEB3
names: Caution
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL6 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: N-Glycosylated.

9925:MYO1A
gene id: 9925:MYO1A
uniprot id: A0A452E9U3
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9925:SLC13A3
gene id: 9925:SLC13A3
uniprot id: A0A452FZ33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.
messages: Membrane

9925:LOC102173838
gene id: 9925:LOC102173838
uniprot id: A0A452DP13
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:HMGN1
gene id: 9925:HMGN1
uniprot id: A0A452DQR9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9925:EML4
gene id: 9925:EML4
uniprot id: A0A452F0E0
uniprot id: A0A452F0H6
names: Similarity
messages: Belongs to the WD repeat EMAP family.

9925:DPY19L4
gene id: 9925:DPY19L4
uniprot id: A0A8C2RY64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dpy-19 family.
messages: Membrane
messages: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins.

9925:RPL8
gene id: 9925:RPL8
uniprot id: A0A452G0W0
names: Similarity
messages: Belongs to the universal ribosomal protein uL2 family.

9925:SH3GL2
gene id: 9925:SH3GL2
uniprot id: A0A452FDV4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endophilin family.
messages: Membrane

9925:OPA3
gene id: 9925:OPA3
uniprot id: A0A452EYT7
uniprot id: A0A8C2RYD7
names: Function
names: Similarity
messages: Belongs to the OPA3 family.
messages: May play some role in mitochondrial processes.

9925:RCAN3
gene id: 9925:RCAN3
uniprot id: A0A452FKG8
names: Similarity
messages: Belongs to the RCAN family.

9925:PSEN2
gene id: 9925:PSEN2
uniprot id: A0A452G168
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase A22A family.
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Homodimer.
messages: Membrane
messages: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
messages: The PAL motif is required for normal active site conformation.

9925:MMP11
gene id: 9925:MMP11
uniprot id: A0A452FG56
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9925:GSTCD
gene id: 9925:GSTCD
uniprot id: A0A452F3H9
names: Similarity
messages: Belongs to the GSTCD family.

9925:LOC108633414
gene id: 9925:LOC108633414
uniprot id: A0A452E1V4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:LOC108636006
gene id: 9925:LOC108636006
uniprot id: A0A452DST2
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9925:NSUN4
gene id: 9925:NSUN4
uniprot id: A0A452FWY3
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9925:ATXN1
gene id: 9925:ATXN1
uniprot id: A0A452F616
uniprot id: A0A452F620
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATXN1 family.
messages: Nucleus

9925:VPS72
gene id: 9925:VPS72
uniprot id: A0A452EME9
names: Function
names: Similarity
messages: Belongs to the VPS72/YL1 family.
messages: Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling.

9925:ACSL1
gene id: 9925:ACSL1
uniprot id: A0A452FP97
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent AMP-binding enzyme family.
messages: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.
messages: Endoplasmic reticulum membrane
messages: Mitochondrion outer membrane

9925:USP14
gene id: 9925:USP14
uniprot id: A0A452DSP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase C19 family. USP14/UBP6 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS.

9925:PRKAA1
gene id: 9925:PRKAA1
uniprot id: A0A452F0I9
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.

9925:FAM69A
gene id: 9925:FAM69A
uniprot id: A0A452FDA5
uniprot id: A0A452FDJ9
names: Similarity
messages: Belongs to the DIPK family.

9925:NUP155
gene id: 9925:NUP155
uniprot id: A0A452EYE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the non-repetitive/WGA-negative nucleoporin family.
messages: nuclear pore complex

9925:ALB
gene id: 9925:ALB
uniprot id: A0A452F7K4
names: Subcellular Location Annotation
messages: Secreted

9925:TRIP10
gene id: 9925:TRIP10
uniprot id: A0A452FPC7
uniprot id: A0A452FPD1
names: Subcellular Location Annotation
messages: cytoskeleton

9925:LOC102171420
gene id: 9925:LOC102171420
uniprot id: A0A452DVD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TOMM40L
gene id: 9925:TOMM40L
uniprot id: A0A452F2K4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Tom40 family.
messages: Membrane
messages: Mitochondrion outer membrane

9925:SFR1
gene id: 9925:SFR1
uniprot id: A0A452FDB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SFR1/MEI5 family.
messages: Nucleus

9925:DSG2
gene id: 9925:DSG2
uniprot id: A0A452EUS1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: desmosome

9925:CENPO
gene id: 9925:CENPO
uniprot id: A0A452EK44
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CENP-O/MCM21 family.
messages: Nucleus

9925:GCSH
gene id: 9925:GCSH
uniprot id: A0A452E1E4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GcvH family.
messages: Binds 1 lipoyl cofactor covalently.
messages: Mitochondrion
messages: The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
messages: The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).
messages: The glycine cleavage system is composed of four proteins: P, T, L and H.

9925:PAQR6
gene id: 9925:PAQR6
uniprot id: A0A452F9Q1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9925:TRAF3
gene id: 9925:TRAF3
uniprot id: A0A452G7I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TNF receptor-associated factor family.
messages: Cytoplasm

9925:B3GNT5
gene id: 9925:B3GNT5
uniprot id: A0A452DVF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:TACSTD2
gene id: 9925:TACSTD2
uniprot id: A0A452EEQ6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPCAM family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:PLCB4
gene id: 9925:PLCB4
uniprot id: A0A452FTU9
uniprot id: A0A452FU18
uniprot id: A0A452FUL5
names: Cofactor
names: Function
messages: Binds 1 Ca(2+) ion per subunit.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9925:LOC102177727
gene id: 9925:LOC102177727
uniprot id: A0A452EDR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:SOX14
gene id: 9925:SOX14
uniprot id: B7SZV1
names: Subcellular Location Annotation
messages: Nucleus

9925:MS4A13
gene id: 9925:MS4A13
uniprot id: A0A452FH21
names: Similarity
messages: Belongs to the MS4A family.

9925:RRN3
gene id: 9925:RRN3
uniprot id: A0A452EP64
names: Similarity
messages: Belongs to the RRN3 family.

9925:TMED2
gene id: 9925:TMED2
uniprot id: A0A452EM38
uniprot id: A0A8C2QZJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9925:FARSB
gene id: 9925:FARSB
uniprot id: A0A452EKA8
names: Similarity
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.

9925:OTULIN
gene id: 9925:OTULIN
uniprot id: A0A452FK61
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C65 family. Otulin subfamily.
messages: Cytoplasm

9925:SPPL2A
gene id: 9925:SPPL2A
uniprot id: A0A452FDS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Endosome membrane
messages: Lysosome membrane
messages: Membrane

9925:STX1B
gene id: 9925:STX1B
uniprot id: A0A452EW87
names: Similarity
messages: Belongs to the syntaxin family.

9925:ANXA6
gene id: 9925:ANXA6
uniprot id: A0A452EVG2
uniprot id: A0A452EVH6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
messages: Melanosome

9925:STMN2
gene id: 9925:STMN2
uniprot id: A0A452EK85
names: Similarity
messages: Belongs to the stathmin family.

9925:NMT1
gene id: 9925:NMT1
uniprot id: A0A452DX74
names: Function
names: Similarity
messages: Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.
messages: Belongs to the NMT family.

9925:SYCP2L
gene id: 9925:SYCP2L
uniprot id: A0A452F4U2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SYCP2 family.
messages: Nucleus

9925:NDFIP1
gene id: 9925:NDFIP1
uniprot id: A0A452G350
names: Subcellular Location Annotation
messages: Endosome membrane
messages: Membrane

9925:MSMB
gene id: 9925:MSMB
uniprot id: A0A8C2S3Z5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-microseminoprotein family.
messages: Secreted

9925:MEGF9
gene id: 9925:MEGF9
uniprot id: A0A452GBE0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102171143
gene id: 9925:LOC102171143
uniprot id: A0A452EYL2
names: Similarity
messages: Belongs to the apolipoprotein L family.

9925:SLC39A7
gene id: 9925:SLC39A7
uniprot id: A0A452FWS5
names: Subcellular Location Annotation
messages: Membrane

9925:TMEM107
gene id: 9925:TMEM107
uniprot id: A0A452G122
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102188961
gene id: 9925:LOC102188961
uniprot id: A0A452DZS1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ARL14
gene id: 9925:ARL14
uniprot id: A0A452DSL2
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9925:CRY2
gene id: 9925:CRY2
uniprot id: A0A452FUT4
names: Cofactor
names: Similarity
messages: Belongs to the DNA photolyase class-1 family.
messages: Binds 1 FAD per subunit.

9925:HSD17B11
gene id: 9925:HSD17B11
uniprot id: A0A452E9U4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:MED13L
gene id: 9925:MED13L
uniprot id: A0A452EZP7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 13 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9925:GBX2
gene id: 9925:GBX2
uniprot id: A0A452EY65
names: Subcellular Location Annotation
messages: Nucleus

9925:CLIC6
gene id: 9925:CLIC6
uniprot id: A0A452EVK4
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cytoplasm
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane

9925:CADM2
gene id: 9925:CADM2
uniprot id: A0A452FWQ7
names: Similarity
messages: Belongs to the nectin family.

9925:DCAF1
gene id: 9925:DCAF1
uniprot id: A0A452DUX3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPRBP/DCAF1 family.
messages: Nucleus

9925:EEF1B2
gene id: 9925:EEF1B2
uniprot id: H9TKZ5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.
messages: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.

9925:ITGB2
gene id: 9925:ITGB2
uniprot id: Q5VI41
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the integrin beta chain family.
messages: Both Ser-746 and Ser-757 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-759 (but not on Ser-757) allows interaction with 14-3-3 proteins.
messages: Cell membrane
messages: Heterodimer of an alpha and a beta subunit. The ITGB2 beta subunit associates with the ITGAL, ITGAM, ITGAX or ITGAD alpah subunits. Found in a complex with CD177 and ITGAM/CD11b. Interacts with FGR. Interacts with COPS5 and RANBP9. Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23). Interacts with THBD.
messages: Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils.
messages: Membrane raft
messages: The VWFA domain (or beta I domain) contains three cation-binding sites: the ligand-associated metal ion-binding site (LIMBS or SyMBS), the metal ion-dependent adhesion site (MIDAS), and the adjacent MIDAS site (ADMIDAS). This domain is also part of the ligand-binding site.

9925:ENDOU
gene id: 9925:ENDOU
uniprot id: A0A452F3I8
names: Similarity
names: Subunit
messages: Belongs to the ENDOU family.
messages: Monomer.

9925:SMC2
gene id: 9925:SMC2
uniprot id: A0A452DRD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family. SMC2 subfamily.
messages: Chromosome
messages: Nucleus

9925:LOC102180474
gene id: 9925:LOC102180474
uniprot id: A0A452E8B1
names: Similarity
messages: Belongs to the glycosyl hydrolase 1 family.

9925:ADRA2C
gene id: 9925:ADRA2C
uniprot id: A0A452DXT7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:ARL3
gene id: 9925:ARL3
uniprot id: A0A452EAL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9925:PM20D2
gene id: 9925:PM20D2
uniprot id: A0A452ERD0
names: Function
names: Similarity
messages: Belongs to the peptidase M20A family.
messages: Catalyzes the peptide bond hydrolysis in dipeptides having basic amino acids lysine, ornithine or arginine at C-terminus.

9925:F13A1
gene id: 9925:F13A1
uniprot id: A0A452FF40
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9925:SLC6A17
gene id: 9925:SLC6A17
uniprot id: A0A452FJR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

9925:MMP12
gene id: 9925:MMP12
uniprot id: A0A452G894
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9925:WNT5A
gene id: 9925:WNT5A
uniprot id: A0A452EU78
uniprot id: A0A452EUB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9925:PTAR1
gene id: 9925:PTAR1
uniprot id: A0A452DUD4
names: Similarity
messages: Belongs to the protein prenyltransferase subunit alpha family.

9925:AMPD3
gene id: 9925:AMPD3
uniprot id: A0A452EG84
uniprot id: A0A452EG85
uniprot id: A0A452EGC0
uniprot id: A0A452EGJ2
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.

9925:TNFSF14
gene id: 9925:TNFSF14
uniprot id: I3NP96
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9925:RPLP2
gene id: 9925:RPLP2
uniprot id: A0A452F1F7
names: Function
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Plays an important role in the elongation step of protein synthesis.

9925:DNAJC2
gene id: 9925:DNAJC2
uniprot id: A0A452FIC9
names: Function
names: Subcellular Location Annotation
messages: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.
messages: cytosol

9925:DVL1
gene id: 9925:DVL1
uniprot id: A0A452ENR1
names: Similarity
messages: Belongs to the DSH family.

9925:RPS28
gene id: 9925:RPS28
uniprot id: A0A452F1P5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

9925:LOC102182511
gene id: 9925:LOC102182511
uniprot id: A0A452E737
names: Function
names: Similarity
messages: Belongs to the PET191 family.
messages: Involved in an early step of the mitochondrial complex IV assembly process.

9925:ADD3
gene id: 9925:ADD3
uniprot id: A0A452FCB9
uniprot id: A0A452FCG5
names: Similarity
messages: Belongs to the aldolase class II family. Adducin subfamily.

9925:SPSB2
gene id: 9925:SPSB2
uniprot id: A0A452FQG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Cytoplasm

9925:LOC102190481
gene id: 9925:LOC102190481
uniprot id: A0A452E5J1
names: Similarity
messages: Belongs to the GST superfamily. Mu family.

9925:SIX1
gene id: 9925:SIX1
uniprot id: A0A452G009
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102180243
gene id: 9925:LOC102180243
uniprot id: A0A452DQG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:DHCR7
gene id: 9925:DHCR7
uniprot id: A0A452EN35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Membrane

9925:AKAP3
gene id: 9925:AKAP3
uniprot id: A0A452G3M2
uniprot id: A0A452G3R9
names: Similarity
messages: Belongs to the AKAP110 family.

9925:SFTPD
gene id: 9925:SFTPD
uniprot id: A0A452F525
names: Similarity
names: Subunit
messages: Belongs to the SFTPD family.
messages: Oligomeric complex of 4 set of homotrimers.

9925:USP16
gene id: 9925:USP16
uniprot id: A0A452G3Y9
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase C19 family. USP16 subfamily.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Homotetramer.
messages: Nucleus
messages: Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.
messages: Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.
messages: The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin.

9925:SGMS1
gene id: 9925:SGMS1
uniprot id: A0A452FH92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sphingomyelin synthase family.
messages: Membrane

9925:RNF152
gene id: 9925:RNF152
uniprot id: A0A452E7R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNF152 family.
messages: Lysosome membrane
messages: Membrane

9925:DYRK2
gene id: 9925:DYRK2
uniprot id: A0A452FX07
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.

9925:IL4R
gene id: 9925:IL4R
uniprot id: A0A452FD64
names: Function
names: Similarity
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.

9925:PDE8B
gene id: 9925:PDE8B
uniprot id: A0A452FS51
uniprot id: A0A452FS95
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9925:UCK2
gene id: 9925:UCK2
uniprot id: A0A452FUW7
names: Similarity
messages: Belongs to the uridine kinase family.

9925:SNRPN
gene id: 9925:SNRPN
uniprot id: A0A452F0H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

9925:ACTBL2
gene id: 9925:ACTBL2
uniprot id: A0A452DT40
names: Similarity
messages: Belongs to the actin family.

9925:INSL3
gene id: 9925:INSL3
uniprot id: Q9N0Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the insulin family.
messages: Secreted
messages: Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor.

9925:LOC102188608
gene id: 9925:LOC102188608
uniprot id: A0A452FJI6
uniprot id: A0A452FJJ4
names: Similarity
messages: Belongs to the calcitonin family.

9925:POLR2L
gene id: 9925:POLR2L
uniprot id: A0A452FR10
names: Similarity
messages: Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.

9925:ACTN3
gene id: 9925:ACTN3
uniprot id: A0A452EI96
names: Similarity
messages: Belongs to the alpha-actinin family.

9925:FUCA1
gene id: 9925:FUCA1
uniprot id: A0A452DS37
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

9925:DERL1
gene id: 9925:DERL1
uniprot id: A0A452F6Z6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the derlin family.
messages: Endoplasmic reticulum membrane
messages: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.
messages: Membrane

9925:HACD3
gene id: 9925:HACD3
uniprot id: A0A8C2PF29
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:BCAP29
gene id: 9925:BCAP29
uniprot id: A0A452EHM9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCAP29/BCAP31 family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays a role in the export of secreted proteins in the ER.

9925:SS18L2
gene id: 9925:SS18L2
uniprot id: A0A452FG99
names: Similarity
messages: Belongs to the SS18 family.

9925:MAB21L3
gene id: 9925:MAB21L3
uniprot id: A0A452F7C4
names: Similarity
messages: Belongs to the mab-21 family.

9925:TPM4
gene id: 9925:TPM4
uniprot id: A0A452E083
uniprot id: A0A452E0A4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tropomyosin family.
messages: cytoskeleton

9925:LOC102181595
gene id: 9925:LOC102181595
uniprot id: A0A452EFB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:SLC17A1
gene id: 9925:SLC17A1
uniprot id: A0A452G4E3
names: Subcellular Location Annotation
messages: Membrane

9925:EFNA5
gene id: 9925:EFNA5
uniprot id: A0A8C2PCP5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:ZIC5
gene id: 9925:ZIC5
uniprot id: A0A452E2Y5
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9925:FZD10
gene id: 9925:FZD10
uniprot id: A0A452DWU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Membrane

9925:HBBC
gene id: 9925:HBBC
uniprot id: P02078
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.
messages: Red blood cells.
messages: This type of beta-C chain is found when anemia has been experimentally produced.

9925:FMO2
gene id: 9925:FMO2
uniprot id: A0A452FG45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9925:LOC102191547
gene id: 9925:LOC102191547
uniprot id: A0A452ELD1
uniprot id: O18809
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the cytochrome P450 family.
messages: Bioactivates 3-methylindole (3MI) by dehydrogenation to the putative electrophile 3-methylene-indolenine. Stereoselectively catalyzes the formation of the 1R,2S-oxide from naphthalene. Lack activity with other common P450 substrates including 7-ethoxycoumarin.
messages: Endoplasmic reticulum membrane
messages: Lung specific.
messages: Membrane
messages: Microsome membrane

9925:UBALD2
gene id: 9925:UBALD2
uniprot id: A0A452FHQ2
names: Similarity
messages: Belongs to the UBALD family.

9925:TRNAU1AP
gene id: 9925:TRNAU1AP
uniprot id: A0A452FS86
uniprot id: A0A452FSR1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM TRSPAP family.
messages: Cytoplasm
messages: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.
messages: Nucleus

9925:PHYHIPL
gene id: 9925:PHYHIPL
uniprot id: A0A452F6E8
names: Similarity
messages: Belongs to the PHYHIP family.

9925:CDK5RAP1
gene id: 9925:CDK5RAP1
uniprot id: A0A452G5T0
names: Similarity
messages: Belongs to the methylthiotransferase family. MiaB subfamily.

9925:LOC102168750
gene id: 9925:LOC102168750
uniprot id: A0A452DNC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:NSUN2
gene id: 9925:NSUN2
uniprot id: A0A452F9G6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
messages: extracellular exosome

9925:OSBPL10
gene id: 9925:OSBPL10
uniprot id: A0A452F260
names: Similarity
messages: Belongs to the OSBP family.

9925:DLGAP3
gene id: 9925:DLGAP3
uniprot id: A0A452FT61
names: Similarity
messages: Belongs to the SAPAP family.

9925:NEK6
gene id: 9925:NEK6
uniprot id: A0A452EJL8
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:CCR9
gene id: 9925:CCR9
uniprot id: A0A452EM82
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:LOC102189694
gene id: 9925:LOC102189694
uniprot id: A0A452E035
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:NKX2-3
gene id: 9925:NKX2-3
uniprot id: A0A452F1N9
names: Subcellular Location Annotation
messages: Nucleus

9925:STK38L
gene id: 9925:STK38L
uniprot id: A0A452EP22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily.
messages: Cytoplasm

9925:RPL36
gene id: 9925:RPL36
uniprot id: A0A452EMZ1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL36 family.

9925:BMP5
gene id: 9925:BMP5
uniprot id: A0A452E3P9
names: Similarity
messages: Belongs to the TGF-beta family.

9925:ETFRF1
gene id: 9925:ETFRF1
uniprot id: A0A452FRN9
names: Similarity
messages: Belongs to the complex I LYR family.

9925:HTRA3
gene id: 9925:HTRA3
uniprot id: A0A452FRJ7
names: Similarity
messages: Belongs to the peptidase S1C family.

9925:TMEM86B
gene id: 9925:TMEM86B
uniprot id: A0A8C2XWK8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM86 family.
messages: Membrane

9925:AK2
gene id: 9925:AK2
uniprot id: A0A452FVS1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK2 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Mitochondrion intermembrane space
messages: Monomer.

9925:DNAL4
gene id: 9925:DNAL4
uniprot id: A0A452F6V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9925:ZSCAN16
gene id: 9925:ZSCAN16
uniprot id: A0A452EB82
names: Subcellular Location Annotation
messages: Nucleus

9925:PTHLH
gene id: 9925:PTHLH
uniprot id: E2EAI4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the parathyroid hormone family.
messages: Cytoplasm
messages: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.
messages: Nucleus
messages: Osteostatin is a potent inhibitor of osteoclastic bone resorption.
messages: PTHrP interacts with PTH1R (via N-terminal extracellular domain).
messages: Secreted
messages: There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.

9925:IMP4
gene id: 9925:IMP4
uniprot id: A0A452GB15
names: Subcellular Location Annotation
messages: nucleolus

9925:KIN
gene id: 9925:KIN
uniprot id: A0A452EEV9
names: Similarity
messages: Belongs to the KIN17 family.

9925:LOC102177737
gene id: 9925:LOC102177737
uniprot id: A0A452DWF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:HARBI1
gene id: 9925:HARBI1
uniprot id: A0A452EKN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HARBI1 family.
messages: Cytoplasm
messages: Nucleus
messages: Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity.

9925:GDF7
gene id: 9925:GDF7
uniprot id: A0A452E7W6
names: Similarity
messages: Belongs to the TGF-beta family.

9925:POMGNT1
gene id: 9925:POMGNT1
uniprot id: A0A452EN45
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 13 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.
messages: The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.
messages: The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein.

9925:ANKRD34C
gene id: 9925:ANKRD34C
uniprot id: A0A452E181
names: Similarity
messages: Belongs to the ANKRD34 family.

9925:SLC30A3
gene id: 9925:SLC30A3
uniprot id: A0A452G943
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
messages: Membrane

9925:RPA1
gene id: 9925:RPA1
uniprot id: A0A452G730
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
messages: Belongs to the replication factor A protein 1 family.
messages: Component of the heterotrimeric canonical replication protein A complex (RPA).
messages: PML body

9925:ATP8A2
gene id: 9925:ATP8A2
uniprot id: A0A452DZ29
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9925:LOC102176137
gene id: 9925:LOC102176137
uniprot id: A0A452E0K5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CSK
gene id: 9925:CSK
uniprot id: A0A452FQZ5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9925:LOC102173852
gene id: 9925:LOC102173852
uniprot id: A0A452ECJ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9925:ZDHHC22
gene id: 9925:ZDHHC22
uniprot id: A0A452EFV0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9925:LOC102188498
gene id: 9925:LOC102188498
uniprot id: A0A452EDT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ADGRF4
gene id: 9925:ADGRF4
uniprot id: A0A452EP76
names: Subcellular Location Annotation
messages: Membrane

9925:PEX16
gene id: 9925:PEX16
uniprot id: A0A452E7Z4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxin-16 family.
messages: Peroxisome membrane

9925:MED21
gene id: 9925:MED21
uniprot id: A0A452EYI5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 21 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9925:CPEB3
gene id: 9925:CPEB3
uniprot id: A0A452EZR3
names: Similarity
messages: Belongs to the RRM CPEB family.

9925:G6PC3
gene id: 9925:G6PC3
uniprot id: A0A452E0S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucose-6-phosphatase family.
messages: Endoplasmic reticulum membrane

9925:CANT1
gene id: 9925:CANT1
uniprot id: A0A452EYE6
names: Similarity
messages: Belongs to the apyrase family.

9925:UBE2K
gene id: 9925:UBE2K
uniprot id: A9LM11
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9925:LPCAT1
gene id: 9925:LPCAT1
uniprot id: A0A452DY95
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9925:C16H1orf27
gene id: 9925:C16H1orf27
uniprot id: A0A8C2SJW7
uniprot id: A0A8C2SM42
names: Function
names: Similarity
messages: Belongs to the ODR-4 family.
messages: May play a role in the trafficking of a subset of G-protein coupled receptors.

9925:ADAM10
gene id: 9925:ADAM10
uniprot id: A0A452DUH2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:HSP90AA1
gene id: 9925:HSP90AA1
uniprot id: A0A452FMZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heat shock protein 90 family.
messages: Melanosome

9925:KCNK2
gene id: 9925:KCNK2
uniprot id: A0A452FI40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9925:TNFSF9
gene id: 9925:TNFSF9
uniprot id: A0A452DQE5
uniprot id: A0A8C2NIC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Secreted

9925:LOC108638300
gene id: 9925:LOC108638300
uniprot id: A0A452DUN1
names: Function
messages: The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulfur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa).

9925:SFPQ
gene id: 9925:SFPQ
uniprot id: A0A452FRY3
uniprot id: A0A452FS13
names: Subcellular Location Annotation
messages: Nucleus speckle

9925:ZDHHC7
gene id: 9925:ZDHHC7
uniprot id: A0A452DZE6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9925:WDFY1
gene id: 9925:WDFY1
uniprot id: A0A452DW48
names: Subcellular Location Annotation
messages: Early endosome
messages: Endosome

9925:TLR9
gene id: 9925:TLR9
uniprot id: B3VI23
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Endoplasmic reticulum membrane
messages: Endosome
messages: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production.
messages: Lysosome
messages: Membrane
messages: phagosome

9925:DVL2
gene id: 9925:DVL2
uniprot id: A0A452G429
names: Similarity
messages: Belongs to the DSH family.

9925:EHD3
gene id: 9925:EHD3
uniprot id: A0A452F1T8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9925:ARMC8
gene id: 9925:ARMC8
uniprot id: A0A452DNH2
uniprot id: A0A452DNI7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:SLC2A9
gene id: 9925:SLC2A9
uniprot id: A0A452EWL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane

9925:LOC102175652
gene id: 9925:LOC102175652
uniprot id: A0A452DTG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102187636
gene id: 9925:LOC102187636
uniprot id: A0A452EA29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SLC7A14
gene id: 9925:SLC7A14
uniprot id: A0A452F055
names: Subcellular Location Annotation
messages: Membrane

9925:SEC23A
gene id: 9925:SEC23A
uniprot id: A0A452G819
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SEC23/SEC24 family. SEC23 subfamily.
messages: COPII-coated vesicle membrane
messages: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: cytosol

9925:HLX
gene id: 9925:HLX
uniprot id: A0A452EK78
names: Subcellular Location Annotation
messages: Nucleus

9925:MKNK2
gene id: 9925:MKNK2
uniprot id: A0A452G8Z5
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:LOC102174578
gene id: 9925:LOC102174578
uniprot id: A0A8C2RWA2
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9925:PSMC4
gene id: 9925:PSMC4
uniprot id: A0A452EVH8
names: Similarity
messages: Belongs to the AAA ATPase family.

9925:ADGRF1
gene id: 9925:ADGRF1
uniprot id: A0A452FZX8
names: Subcellular Location Annotation
messages: Membrane

9925:MRPL27
gene id: 9925:MRPL27
uniprot id: A0A452DVB9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

9925:LOC102173997
gene id: 9925:LOC102173997
uniprot id: A0A0C4Y1X3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c family.
messages: Binds 1 heme group per subunit.
messages: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.
messages: Mitochondrion intermembrane space
messages: Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

9925:LOC102188971
gene id: 9925:LOC102188971
uniprot id: A0A452DTL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ASCC3
gene id: 9925:ASCC3
uniprot id: A0A452FU25
names: Similarity
messages: Belongs to the helicase family.

9925:RNFT1
gene id: 9925:RNFT1
uniprot id: A0A452F858
names: Subcellular Location Annotation
messages: Membrane

9925:FERMT2
gene id: 9925:FERMT2
uniprot id: A0A452FVF2
names: Similarity
messages: Belongs to the kindlin family.

9925:KCNJ4
gene id: 9925:KCNJ4
uniprot id: A0A452DWI8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.
messages: Membrane

9925:TK1
gene id: 9925:TK1
uniprot id: A0A452EXI1
names: Similarity
messages: Belongs to the thymidine kinase family.

9925:HACL1
gene id: 9925:HACL1
uniprot id: A0A452EF36
names: Similarity
messages: Belongs to the TPP enzyme family.

9925:ENPP3
gene id: 9925:ENPP3
uniprot id: A0A452DM80
names: Subcellular Location Annotation
messages: Secreted

9925:PRDM10
gene id: 9925:PRDM10
uniprot id: A0A452G7X3
uniprot id: A0A452G869
names: Function
names: Subcellular Location Annotation
messages: May be involved in transcriptional regulation.
messages: Nucleus

9925:ANXA11
gene id: 9925:ANXA11
uniprot id: A0A452DL82
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9925:TPMT
gene id: 9925:TPMT
uniprot id: A0A452DS26
names: Similarity
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.
messages: Monomer.

9925:PAQR5
gene id: 9925:PAQR5
uniprot id: A0A452EWU5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9925:CEP76
gene id: 9925:CEP76
uniprot id: A0A452FH15
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CEP76 family.
messages: Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.
messages: centriole

9925:ECHDC1
gene id: 9925:ECHDC1
uniprot id: A0A452DNY1
names: Similarity
messages: Belongs to the enoyl-CoA hydratase/isomerase family.

9925:PDHB
gene id: 9925:PDHB
uniprot id: A0A452EB05
names: Function
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
messages: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.

9925:PRPH2
gene id: 9925:PRPH2
uniprot id: A0A452EY74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRPH2/ROM1 family.
messages: Membrane

9925:MTHFD1
gene id: 9925:MTHFD1
uniprot id: A0A452DNI3
names: Similarity
names: Subunit
messages: Homodimer.
messages: In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.
messages: In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

9925:COQ5
gene id: 9925:COQ5
uniprot id: A0A452F991
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
messages: Mitochondrion inner membrane

9925:IKBKAP
gene id: 9925:IKBKAP
uniprot id: A0A452G121
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP1/IKA1 family.
messages: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
messages: Cytoplasm
messages: Nucleus

9925:ASTE1
gene id: 9925:ASTE1
uniprot id: A0A452FK14
names: Similarity
messages: Belongs to the asteroid family.

9925:GSG2
gene id: 9925:GSG2
uniprot id: A0A452E3Y0
names: Subcellular Location Annotation
messages: Chromosome

9925:PSMD5
gene id: 9925:PSMD5
uniprot id: A0A452FI84
names: Similarity
messages: Belongs to the proteasome subunit S5B/HSM3 family.

9925:PARK7
gene id: 9925:PARK7
uniprot id: A0A452FM54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C56 family.
messages: Membrane raft

9925:NOP10
gene id: 9925:NOP10
uniprot id: A0A452EA49
names: Similarity
messages: Belongs to the NOP10 family.

9925:LOC100861175
gene id: 9925:LOC100861175
uniprot id: Q6R646
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9925:PRKRIP1
gene id: 9925:PRKRIP1
uniprot id: A0A452FSR7
names: Similarity
messages: Belongs to the PRKRIP1 family.

9925:MRPL3
gene id: 9925:MRPL3
uniprot id: A0A452G023
names: Similarity
messages: Belongs to the universal ribosomal protein uL3 family.

9925:MARK3
gene id: 9925:MARK3
uniprot id: A0A452F5H0
uniprot id: A0A452F5R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9925:FXYD6
gene id: 9925:FXYD6
uniprot id: A0A452EXD0
names: Similarity
messages: Belongs to the FXYD family.

9925:DNAJC27
gene id: 9925:DNAJC27
uniprot id: A0A452EIN1
names: Function
names: Subunit
messages: GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.
messages: Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).

9925:MRE11A
gene id: 9925:MRE11A
uniprot id: A0A452FJ80
uniprot id: A0A452FKE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRE11/RAD32 family.
messages: Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
messages: Nucleus

9925:CASS4
gene id: 9925:CASS4
uniprot id: A0A452G2V8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9925:LOC102181083
gene id: 9925:LOC102181083
uniprot id: A0A452E1V4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:PURB
gene id: 9925:PURB
uniprot id: A0A452E7Q9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

9925:PPBP
gene id: 9925:PPBP
uniprot id: A0A452FUC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9925:ADCY9
gene id: 9925:ADCY9
uniprot id: A0A452E8C5
names: Similarity
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

9925:LPAR5
gene id: 9925:LPAR5
uniprot id: A0A452DR20
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:CRYBA4
gene id: 9925:CRYBA4
uniprot id: A0A452G1C1
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9925:IL37
gene id: 9925:IL37
uniprot id: A0A452DPS1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-1 family.
messages: Secreted

9925:LRP6
gene id: 9925:LRP6
uniprot id: A0A452ENK7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LDLR family.
messages: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes.
messages: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:STAT6
gene id: 9925:STAT6
uniprot id: A0A8C2Y3F5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9925:PRC1
gene id: 9925:PRC1
uniprot id: A0A452DNM8
uniprot id: A0A452DNQ2
names: Similarity
messages: Belongs to the MAP65/ASE1 family.

9925:LOC102174258
gene id: 9925:LOC102174258
uniprot id: A0A452EBE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:MAPT
gene id: 9925:MAPT
uniprot id: A0A452G6R7
uniprot id: A0A452G6X8
uniprot id: O02828
names: Domain
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Cell membrane
messages: Expressed in neurons.
messages: Interacts with MARK1, MARK2, MARK3 and MARK4 (By similarity). Interacts with SQSTM1 when polyubiquitinated (By similarity). Interacts with PSMC2 through SQSTM1 (By similarity). Interacts with FKBP4 (By similarity). Binds to CSNK1D (By similarity). Interacts with SGK1 (By similarity). Interacts with PIN1 (By similarity). Interacts with LRRK2 (By similarity). Interacts with LRP1, leading to endocytosis; this interaction is reduced in the presence of LRPAP1/RAP (By similarity).
messages: Membrane
messages: Phosphorylation at various serine and threonine residues in S-P or T-P motifs by proline-directed protein kinases (PDPK1, CDK1, CDK5, GSK3, MAPK) (a few sites per protein in interphase, more in mitosis), and at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1, MARK2, MARK3, MARK4), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylation at Ser-224 by BRSK1 and BRSK2 in neurons affects ability to bind microtubules and plays a role in neuron polarization. Phosphorylated by PHK. Dephosphorylation at several serine and threonine residues by the serine/threonine phosphatase PPP5C (By similarity).
messages: Polyubiquitinated. Requires functional TRAF6 and may provoke SQSTM1-dependent degradation by the proteasome (By similarity).
messages: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
messages: The tau/MAP repeat binds to tubulin. Type I isoforms contain 3 repeats while type II isoforms contain 4 repeats.
messages: axon
messages: cytoskeleton
messages: cytosol
messages: dendrite

9925:SERPINA10
gene id: 9925:SERPINA10
uniprot id: A0A452FT34
names: Similarity
messages: Belongs to the serpin family.

9925:PDP1
gene id: 9925:PDP1
uniprot id: A0A452FH12
names: Similarity
messages: Belongs to the PP2C family.

9925:SGTB
gene id: 9925:SGTB
uniprot id: A0A452EQA8
names: Similarity
messages: Belongs to the SGT family.

9925:FLAD1
gene id: 9925:FLAD1
uniprot id: A0A452G2N4
names: Function
names: Similarity
messages: Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
messages: In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.
messages: In the N-terminal section; belongs to the MoaB/Mog family.

9925:NCBP2
gene id: 9925:NCBP2
uniprot id: A0A452G489
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RRM NCBP2 family.
messages: Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.
messages: Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.
messages: Nucleus

9925:OLFML2A
gene id: 9925:OLFML2A
uniprot id: A0A8C2XTI2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:OSBP
gene id: 9925:OSBP
uniprot id: A0A452DT55
names: Similarity
messages: Belongs to the OSBP family.

9925:PDE7B
gene id: 9925:PDE7B
uniprot id: A0A452G625
uniprot id: A0A452G628
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9925:NFE2L2
gene id: 9925:NFE2L2
uniprot id: A0A0A7MB97
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

9925:ARID1A
gene id: 9925:ARID1A
uniprot id: A0A452E5F7
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC108636627
gene id: 9925:LOC108636627
uniprot id: A0A452E209
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:OXA1L
gene id: 9925:OXA1L
uniprot id: A0A452FN25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OXA1/ALB3/YidC family.
messages: Membrane

9925:MUL1
gene id: 9925:MUL1
uniprot id: A0A452FFX4
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102176008
gene id: 9925:LOC102176008
uniprot id: A0A452DUC4
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9925:GMDS
gene id: 9925:GMDS
uniprot id: A0A452F187
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.

9925:GSK3B
gene id: 9925:GSK3B
uniprot id: A0A097P8R4
uniprot id: A0A452EM17
names: Similarity
messages: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.

9925:MSR1
gene id: 9925:MSR1
uniprot id: A0A452E777
names: Subcellular Location Annotation
messages: Membrane

9925:RPL15
gene id: 9925:RPL15
uniprot id: A0A452ELX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ribosomal protein eL15 family.
messages: Cytoplasm

9925:DDX55
gene id: 9925:DDX55
uniprot id: A0A452FE04
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9925:KRT39
gene id: 9925:KRT39
uniprot id: A0A452EZJ4
names: Similarity
messages: Belongs to the intermediate filament family.

9925:LOC102180195
gene id: 9925:LOC102180195
uniprot id: A0A452DS00
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:HRH1
gene id: 9925:HRH1
uniprot id: A0A452EC28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:SMPD2
gene id: 9925:SMPD2
uniprot id: A0A452FP12
names: Similarity
messages: Belongs to the neutral sphingomyelinase family.

9925:LSM14A
gene id: 9925:LSM14A
uniprot id: A0A452DZV7
uniprot id: A0A452DZY5
names: Similarity
messages: Belongs to the LSM14 family.

9925:HMGN3
gene id: 9925:HMGN3
uniprot id: A0A8C2RSB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMGN family.
messages: Nucleus

9925:AFMID
gene id: 9925:AFMID
uniprot id: A0A452G8S6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynurenine formamidase family.
messages: Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.
messages: Homodimer.
messages: Nucleus
messages: The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.
messages: cytosol

9925:RNF34
gene id: 9925:RNF34
uniprot id: A0A452E2L7
names: Subcellular Location Annotation
messages: Cell membrane

9925:LOC102168691
gene id: 9925:LOC102168691
uniprot id: A0A452ENX6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 56 family.
messages: Cell membrane
messages: Membrane

9925:HSF4
gene id: 9925:HSF4
uniprot id: A0A452DQF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HSF family.
messages: Nucleus

9925:SIX4
gene id: 9925:SIX4
uniprot id: A0A452EBD2
names: Subcellular Location Annotation
messages: Nucleus

9925:SSX2IP
gene id: 9925:SSX2IP
uniprot id: A0A452G4B6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIP family.
messages: adherens junction
messages: centriolar satellite

9925:PTK6
gene id: 9925:PTK6
uniprot id: A0A452G1W5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9925:ZSCAN23
gene id: 9925:ZSCAN23
uniprot id: A0A452F264
names: Subcellular Location Annotation
messages: Nucleus

9925:GSTM3
gene id: 9925:GSTM3
uniprot id: A0A452E0A7
names: Similarity
messages: Belongs to the GST superfamily. Mu family.

9925:RXRG
gene id: 9925:RXRG
uniprot id: A0A452G8I4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR2 subfamily.
messages: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
messages: Homodimer. Heterodimer; with a rar molecule.
messages: Nucleus
messages: Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.

9925:NFIX
gene id: 9925:NFIX
uniprot id: A0A452FNB9
uniprot id: A0A452FNC3
uniprot id: A0A452FNF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CTF/NF-I family.
messages: Binds DNA as a homodimer.
messages: Nucleus
messages: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

9925:KDELC1
gene id: 9925:KDELC1
uniprot id: A0A452FYZ5
names: Similarity
messages: Belongs to the KDELC family.

9925:LOC102189109
gene id: 9925:LOC102189109
uniprot id: A0A452FIU1
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9925:TMEM116
gene id: 9925:TMEM116
uniprot id: A0A8C2RNE3
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102171676
gene id: 9925:LOC102171676
uniprot id: A0A452E3K5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:BCL7B
gene id: 9925:BCL7B
uniprot id: A0A452DMW9
names: Similarity
messages: Belongs to the BCL7 family.

9925:GGPS1
gene id: 9925:GGPS1
uniprot id: A0A452ER44
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

9925:AP4S1
gene id: 9925:AP4S1
uniprot id: A0A452ETL1
names: Similarity
messages: Belongs to the adaptor complexes small subunit family.

9925:DPP7
gene id: 9925:DPP7
uniprot id: A0A452F4B1
names: Similarity
messages: Belongs to the peptidase S28 family.

9925:NAV2
gene id: 9925:NAV2
uniprot id: A0A452DM61
uniprot id: A0A452DM65
uniprot id: A0A452DM74
names: Similarity
messages: Belongs to the Nav/unc-53 family.

9925:TIMM10B
gene id: 9925:TIMM10B
uniprot id: A0A452FBY5
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9925:LALBA
gene id: 9925:LALBA
uniprot id: A5JSS8
uniprot id: P00712
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Belongs to the glycosyl hydrolase 22 family.
messages: Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).
messages: Mammary gland specific. Secreted in milk.
messages: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
messages: Secreted

9925:DMAP1
gene id: 9925:DMAP1
uniprot id: A0A452FM22
names: Subcellular Location Annotation
messages: Nucleus

9925:PTPN2
gene id: 9925:PTPN2
uniprot id: A0A452EI40
uniprot id: A0A452EI47
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.

9925:TMEFF2
gene id: 9925:TMEFF2
uniprot id: A0A452FZT1
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:SH3RF3
gene id: 9925:SH3RF3
uniprot id: A0A452ETB1
names: Similarity
messages: Belongs to the SH3RF family.

9925:CTNNA1
gene id: 9925:CTNNA1
uniprot id: A0A452DRY3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vinculin/alpha-catenin family.
messages: Cell membrane
messages: Membrane
messages: adherens junction

9925:SCN1B
gene id: 9925:SCN1B
uniprot id: A0A452G6B7
names: Subcellular Location Annotation
messages: Membrane

9925:NRDC
gene id: 9925:NRDC
uniprot id: A0A452F6B6
names: Similarity
messages: Belongs to the peptidase M16 family.

9925:IFI44
gene id: 9925:IFI44
uniprot id: A0A452ECX4
uniprot id: A0A452ED95
names: Similarity
messages: Belongs to the IFI44 family.

9925:SPARCL1
gene id: 9925:SPARCL1
uniprot id: A0A452DTT6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPARC family.
messages: extracellular matrix

9925:NOP16
gene id: 9925:NOP16
uniprot id: A0A452FL79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOP16 family.
messages: nucleolus

9925:RPS21
gene id: 9925:RPS21
uniprot id: A0A452EGY3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS21 family.
messages: Component of the 40S small ribosomal subunit.
messages: Endoplasmic reticulum
messages: Rough endoplasmic reticulum
messages: cytosol

9925:LOC102179166
gene id: 9925:LOC102179166
uniprot id: A0A452DN60
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:S1PR4
gene id: 9925:S1PR4
uniprot id: A0A452EBK6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:LOC102169182
gene id: 9925:LOC102169182
uniprot id: A0A452DR46
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.

9925:OPN5
gene id: 9925:OPN5
uniprot id: A0A452FM79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9925:ADAM19
gene id: 9925:ADAM19
uniprot id: A0A452DRQ2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:MEIG1
gene id: 9925:MEIG1
uniprot id: A0A8C2R5J3
names: Function
names: Similarity
messages: Belongs to the MEIG1 family.
messages: Essential for spermiogenesis.

9925:XPO1
gene id: 9925:XPO1
uniprot id: A0A452F3H8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exportin family.
messages: Cytoplasm

9925:ADM
gene id: 9925:ADM
uniprot id: A0A452FPW9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adrenomedullin family.
messages: Secreted

9925:NUDT17
gene id: 9925:NUDT17
uniprot id: A0A8C2QS10
names: Function
names: Similarity
messages: Belongs to the Nudix hydrolase family.
messages: Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.

9925:SIAH2
gene id: 9925:SIAH2
uniprot id: A0A452EQQ6
names: Domain
names: Function
names: Similarity
messages: Belongs to the SINA (Seven in absentia) family.
messages: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
messages: The RING-type zinc finger domain is essential for ubiquitin ligase activity.
messages: The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family.

9925:PDE4D
gene id: 9925:PDE4D
uniprot id: A0A452EZC8
uniprot id: A0A452EZJ8
names: Cofactor
names: Similarity
messages: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
messages: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

9925:DDX31
gene id: 9925:DDX31
uniprot id: A0A452FBS9
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9925:LOC102170373
gene id: 9925:LOC102170373
uniprot id: A0A452FLD6
names: Similarity
messages: Belongs to the serpin family.

9925:NUDC
gene id: 9925:NUDC
uniprot id: A0A452E1B4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudC family.
messages: Midbody
messages: spindle

9925:LOC102184831
gene id: 9925:LOC102184831
uniprot id: A0A452DUE6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PTER
gene id: 9925:PTER
uniprot id: A0A452DNI8
names: Caution
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.
messages: Binds 2 divalent metal cations per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:CSN1S2
gene id: 9925:CSN1S2
uniprot id: A0A6H0DUE2
uniprot id: P33049
names: Function
names: Polymorphism
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the alpha-casein family.
messages: Important role in the capacity of milk to transport calcium phosphate.
messages: Mammary gland specific. Secreted in milk.
messages: Secreted
messages: The frequencies of the A, B and C alleles is estimated to be 0.85, 0.04 and 0.11 in the French dairy breeds 'Alpine' and 'Saanen'.

9925:LOC102178319
gene id: 9925:LOC102178319
uniprot id: A0A452DRQ7
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:WNT16
gene id: 9925:WNT16
uniprot id: A0A452EV56
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9925:PSMD4
gene id: 9925:PSMD4
uniprot id: A0A452G3P7
names: Similarity
messages: Belongs to the proteasome subunit S5A family.

9925:CD5
gene id: 9925:CD5
uniprot id: A0A452DRH8
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:HS3ST1
gene id: 9925:HS3ST1
uniprot id: A0A452DQN3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9925:ART1
gene id: 9925:ART1
uniprot id: A0A452E7T0
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9925:NPY
gene id: 9925:NPY
uniprot id: A0A452DUF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NPY family.
messages: Secreted

9925:TADA1
gene id: 9925:TADA1
uniprot id: A0A452EN46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TADA1 family.
messages: Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.
messages: Nucleus
messages: Probably involved in transcriptional regulation.

9925:COQ8A
gene id: 9925:COQ8A
uniprot id: A0A452ED42
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9925:S100A7A
gene id: 9925:S100A7A
uniprot id: A0A452FKU3
names: Similarity
messages: Belongs to the S-100 family.

9925:SLC29A4
gene id: 9925:SLC29A4
uniprot id: A0A452EGV9
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Membrane

9925:CNTN1
gene id: 9925:CNTN1
uniprot id: A0A452EVJ3
names: Similarity
messages: Belongs to the immunoglobulin superfamily. Contactin family.

9925:MASTL
gene id: 9925:MASTL
uniprot id: A0A452E9R0
names: Subcellular Location Annotation
messages: Nucleus
messages: centrosome

9925:GC
gene id: 9925:GC
uniprot id: A0A452G129
names: Function
names: Subcellular Location Annotation
messages: Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
messages: Secreted

9925:TNS3
gene id: 9925:TNS3
uniprot id: A0A452GB50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9925:LOC102171083
gene id: 9925:LOC102171083
uniprot id: A0A452E8K3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TYW3
gene id: 9925:TYW3
uniprot id: A0A452E023
names: Function
names: Similarity
messages: Belongs to the TYW3 family.
messages: Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA.

9925:LOC102181752
gene id: 9925:LOC102181752
uniprot id: A0A8C2NCV7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PIP family.
messages: Monomer. Interacts with AZGP1.
messages: Secreted

9925:LOC102190216
gene id: 9925:LOC102190216
uniprot id: A0A452ECT4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SUSD5
gene id: 9925:SUSD5
uniprot id: A0A452DVH9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:HOXB9
gene id: 9925:HOXB9
uniprot id: A0A452FQ53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus
messages: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

9925:SLC39A14
gene id: 9925:SLC39A14
uniprot id: A0A452FVK5
uniprot id: A0A452FVT6
names: Subcellular Location Annotation
messages: Membrane

9925:NDRG1
gene id: 9925:NDRG1
uniprot id: A0A452ET94
names: Similarity
messages: Belongs to the NDRG family.

9925:CHRNB1
gene id: 9925:CHRNB1
uniprot id: A0A452ELM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:NOL6
gene id: 9925:NOL6
uniprot id: A0A452E9A4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRAP family.
messages: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
messages: nucleolus

9925:C18H19orf54
gene id: 9925:C18H19orf54
uniprot id: A0A452G6Z0
names: Similarity
messages: Belongs to the ACTMAP family.

9925:NKX2-1
gene id: 9925:NKX2-1
uniprot id: A0A452FVM6
names: Subcellular Location Annotation
messages: Nucleus

9925:IWS1
gene id: 9925:IWS1
uniprot id: A0A452DYI5
uniprot id: A0A452DYJ4
names: Subcellular Location Annotation
messages: Nucleus

9925:NADK2
gene id: 9925:NADK2
uniprot id: A0A452EC30
uniprot id: A0A452ECI1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAD kinase family.
messages: Homodimer.
messages: Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.
messages: Mitochondrion

9925:NT5C3A
gene id: 9925:NT5C3A
uniprot id: A0A452FI48
uniprot id: A0A452FI94
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrimidine 5'-nucleotidase family.
messages: Cytoplasm

9925:MTFR2
gene id: 9925:MTFR2
uniprot id: A0A452E4I2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MTFR1 family.
messages: Mitochondrion
messages: Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission.

9925:ADRA2A
gene id: 9925:ADRA2A
uniprot id: A0A452DNK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:FAM98C
gene id: 9925:FAM98C
uniprot id: A0A452FAJ3
names: Similarity
messages: Belongs to the FAM98 family.

9925:GJC3
gene id: 9925:GJC3
uniprot id: A0A452DRY2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9925:LOC108635605
gene id: 9925:LOC108635605
uniprot id: A0A452EDM5
names: Function
messages: The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.

9925:DHRS9
gene id: 9925:DHRS9
uniprot id: A0A452F2W4
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:CRTC3
gene id: 9925:CRTC3
uniprot id: A0A452F5X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TORC family.
messages: Cytoplasm
messages: Nucleus

9925:SEMA4G
gene id: 9925:SEMA4G
uniprot id: A0A452F197
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:GATA5
gene id: 9925:GATA5
uniprot id: A0A452ELD5
names: Subcellular Location Annotation
messages: Nucleus

9925:PPM1D
gene id: 9925:PPM1D
uniprot id: A0A452FV70
names: Similarity
messages: Belongs to the PP2C family.

9925:LOC102190016
gene id: 9925:LOC102190016
uniprot id: A0A452E5X4
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9925:TMEM9
gene id: 9925:TMEM9
uniprot id: A0A452F1W5
names: Similarity
messages: Belongs to the TMEM9 family.

9925:LOC102177036
gene id: 9925:LOC102177036
uniprot id: A0A452DRN5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:FAM13A
gene id: 9925:FAM13A
uniprot id: A0A452EV11
uniprot id: A0A452EV24
names: Similarity
messages: Belongs to the FAM13 family.

9925:MTOR
gene id: 9925:MTOR
uniprot id: A0A452FCH1
uniprot id: D9I5T4
names: Similarity
messages: Belongs to the PI3/PI4-kinase family.

9925:FOXP4
gene id: 9925:FOXP4
uniprot id: A0A452DVQ5
names: Subcellular Location Annotation
messages: Nucleus

9925:TAS1R1
gene id: 9925:TAS1R1
uniprot id: A0A452FZ98
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:SPP2
gene id: 9925:SPP2
uniprot id: A0A452FHF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPP2 family.
messages: Could coordinate an aspect of bone turnover.
messages: Secreted

9925:GSTZ1
gene id: 9925:GSTZ1
uniprot id: A0A8C2NPS8
uniprot id: A0A8C2NQL8
uniprot id: A0A8C2QTU0
names: Similarity
messages: Belongs to the GST superfamily. Zeta family.

9925:SAP30
gene id: 9925:SAP30
uniprot id: A0A452EV62
names: Similarity
messages: Belongs to the SAP30 family.

9925:GGT7
gene id: 9925:GGT7
uniprot id: A0A452FS11
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gamma-glutamyltransferase family.
messages: Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.
messages: Membrane

9925:CCT6A
gene id: 9925:CCT6A
uniprot id: A0A452ETE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9925:HEBP2
gene id: 9925:HEBP2
uniprot id: A0A452FS44
names: Similarity
messages: Belongs to the HEBP family.

9925:PSMD9
gene id: 9925:PSMD9
uniprot id: A0A452FD51
names: Similarity
messages: Belongs to the proteasome subunit p27 family.

9925:TOP1
gene id: 9925:TOP1
uniprot id: A0A452FWC1
names: Function
names: Similarity
messages: Belongs to the type IB topoisomerase family.
messages: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

9925:PNLIPRP3
gene id: 9925:PNLIPRP3
uniprot id: A0A452EXK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9925:CWC25
gene id: 9925:CWC25
uniprot id: A0A452EPF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CWC25 family.
messages: Nucleus

9925:ATP6V0E2
gene id: 9925:ATP6V0E2
uniprot id: A0A8C2PE74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase e1/e2 subunit family.
messages: Membrane

9925:DFNA5
gene id: 9925:DFNA5
uniprot id: A0A452G988
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gasdermin family.
messages: Cell membrane
messages: Membrane

9925:FAM118B
gene id: 9925:FAM118B
uniprot id: A0A8C2R5S1
names: Similarity
messages: Belongs to the FAM118 family.

9925:ZDHHC20
gene id: 9925:ZDHHC20
uniprot id: A0A452F7G6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9925:PRPSAP1
gene id: 9925:PRPSAP1
uniprot id: A0A452G7P2
names: Similarity
messages: Belongs to the ribose-phosphate pyrophosphokinase family.

9925:ATP8B1
gene id: 9925:ATP8B1
uniprot id: A0A452EC68
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9925:ZSCAN21
gene id: 9925:ZSCAN21
uniprot id: A0A452F3H3
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102181119
gene id: 9925:LOC102181119
uniprot id: A0A452F149
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

9925:SLC10A4
gene id: 9925:SLC10A4
uniprot id: A0A452G4I3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.
messages: Membrane

9925:TGM5
gene id: 9925:TGM5
uniprot id: A0A452EPE1
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9925:GLP1R
gene id: 9925:GLP1R
uniprot id: A0A452FQ81
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9925:CAMLG
gene id: 9925:CAMLG
uniprot id: A0A452DRW5
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.

9925:GLMP
gene id: 9925:GLMP
uniprot id: A0A452F4D2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GLMP family.
messages: Interacts (via lumenal domain) with lysosomal protein MFSD1; the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stability and lysosomal localization of MFSD1.
messages: Lysosome membrane
messages: Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization.

9925:JAK3
gene id: 9925:JAK3
uniprot id: A0A452DZ12
names: Similarity
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

9925:PRKAR1A
gene id: 9925:PRKAR1A
uniprot id: A0A452E8D8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cAMP-dependent kinase regulatory chain family.
messages: Cell membrane
messages: Membrane

9925:RNF13
gene id: 9925:RNF13
uniprot id: A0A452DU48
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102179966
gene id: 9925:LOC102179966
uniprot id: A0A452E1F9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:EIF5
gene id: 9925:EIF5
uniprot id: A0A452FHV2
names: Similarity
messages: Belongs to the eIF-2-beta/eIF-5 family.

9925:BBS7
gene id: 9925:BBS7
uniprot id: A0A452FKE4
names: Function
names: Subunit
messages: Part of BBSome complex.
messages: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.

9925:CRYBB1
gene id: 9925:CRYBB1
uniprot id: A0A452FT78
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9925:ACER1
gene id: 9925:ACER1
uniprot id: A0A452DWI4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkaline ceramidase family.
messages: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
messages: Membrane

9925:CAMK2G
gene id: 9925:CAMK2G
uniprot id: A0A452E2N0
uniprot id: A0A452E2S0
uniprot id: A0A452E2S8
uniprot id: A0A452E2U3
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9925:S100PBP
gene id: 9925:S100PBP
uniprot id: A0A452F657
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102172428
gene id: 9925:LOC102172428
uniprot id: A0A452G0V0
names: Similarity
messages: Belongs to the apolipoprotein L family.

9925:LOC102173107
gene id: 9925:LOC102173107
uniprot id: A0A452DMD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:GINS4
gene id: 9925:GINS4
uniprot id: A0A452EV27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GINS4/SLD5 family.
messages: Chromosome
messages: Nucleus
messages: Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.

9925:LOC102169925
gene id: 9925:LOC102169925
uniprot id: A0A452F7Y8
names: Similarity
messages: Belongs to the serpin family.

9925:CTSW
gene id: 9925:CTSW
uniprot id: A0A452DRU7
names: Similarity
messages: Belongs to the peptidase C1 family.

9925:NPBWR1
gene id: 9925:NPBWR1
uniprot id: A0A452E5M2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:SPOPL
gene id: 9925:SPOPL
uniprot id: A0A452FFL5
uniprot id: A0A452FGC7
names: Similarity
messages: Belongs to the Tdpoz family.

9925:SCD5
gene id: 9925:SCD5
uniprot id: A0A452F3E5
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acid desaturase type 1 family.
messages: Membrane
messages: The histidine box domains are involved in binding the catalytic metal ions.

9925:LOC102183691
gene id: 9925:LOC102183691
uniprot id: A0A452DQI7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:DCP1B
gene id: 9925:DCP1B
uniprot id: A0A452EJY4
names: Similarity
messages: Belongs to the DCP1 family.

9925:PFN2
gene id: 9925:PFN2
uniprot id: A0A452FL85
names: Similarity
messages: Belongs to the profilin family.

9925:LOC102184512
gene id: 9925:LOC102184512
uniprot id: A0A8C2P3Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase VIIb family.
messages: Membrane
messages: Mitochondrion inner membrane

9925:LOC102191000
gene id: 9925:LOC102191000
uniprot id: A0A452ESX4
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9925:TAF1B
gene id: 9925:TAF1B
uniprot id: A0A452EIN8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRN7/TAF1B family.
messages: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.
messages: nucleolus

9925:OXTR
gene id: 9925:OXTR
uniprot id: A0A452DVB6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

9925:MUC13
gene id: 9925:MUC13
uniprot id: A0A452DNK5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:CSAD
gene id: 9925:CSAD
uniprot id: A0A452G6X6
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9925:GNPAT
gene id: 9925:GNPAT
uniprot id: A0A452EEA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Peroxisome membrane

9925:PSMD8
gene id: 9925:PSMD8
uniprot id: A0A452G754
names: Similarity
messages: Belongs to the proteasome subunit S14 family.

9925:SP4
gene id: 9925:SP4
uniprot id: A0A452E0Q8
names: Subcellular Location Annotation
messages: Nucleus

9925:SF3A3
gene id: 9925:SF3A3
uniprot id: A0A452FFE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SF3A3 family.
messages: Nucleus

9925:LOC102186111
gene id: 9925:LOC102186111
uniprot id: A0A452ELS1
names: Similarity
messages: Belongs to the serpin family.

9925:FOXA1
gene id: 9925:FOXA1
uniprot id: A0A452FTW6
names: Subcellular Location Annotation
messages: Nucleus

9925:PLPP3
gene id: 9925:PLPP3
uniprot id: A0A452FPG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9925:DPEP1
gene id: 9925:DPEP1
uniprot id: A0A452EFM3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.
messages: Homodimer; disulfide-linked.
messages: Membrane

9925:LOC102187580
gene id: 9925:LOC102187580
uniprot id: A0A452EEG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:ZFYVE26
gene id: 9925:ZFYVE26
uniprot id: A0A452FFB4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A.
messages: Midbody
messages: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.

9925:PELO
gene id: 9925:PELO
uniprot id: A0A452EVD1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel.
messages: Cytoplasm

9925:LOC102191128
gene id: 9925:LOC102191128
uniprot id: A0A452DNG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SLC37A4
gene id: 9925:SLC37A4
uniprot id: A0A452G2G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
messages: Membrane

9925:GALNT15
gene id: 9925:GALNT15
uniprot id: A0A452EE99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9925:NFYA
gene id: 9925:NFYA
uniprot id: A0A452FG62
uniprot id: A0A452FG76
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NFYA/HAP2 subunit family.
messages: Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.
messages: Heterotrimer.
messages: Nucleus

9925:CDH24
gene id: 9925:CDH24
uniprot id: A0A452EC04
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9925:DPH3
gene id: 9925:DPH3
uniprot id: A0A452EVU6
names: Similarity
messages: Belongs to the DPH3 family.

9925:ADCK2
gene id: 9925:ADCK2
uniprot id: A0A452G1V7
names: Similarity
messages: Belongs to the protein kinase superfamily. ADCK protein kinase family.

9925:LOC102169614
gene id: 9925:LOC102169614
uniprot id: A0A452DQK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:NTF4
gene id: 9925:NTF4
uniprot id: A0A452DZW8
names: Similarity
messages: Belongs to the NGF-beta family.

9925:ATAD2B
gene id: 9925:ATAD2B
uniprot id: A0A452EWS0
names: Similarity
messages: Belongs to the AAA ATPase family.

9925:FGFBP1
gene id: 9925:FGFBP1
uniprot id: A0A452DX68
names: Similarity
messages: Belongs to the fibroblast growth factor-binding protein family.

9925:OSBPL6
gene id: 9925:OSBPL6
uniprot id: A0A452DY78
uniprot id: A0A452DYE6
uniprot id: A0A452DYR6
uniprot id: A0A452DYV3
names: Similarity
messages: Belongs to the OSBP family.

9925:THOC6
gene id: 9925:THOC6
uniprot id: A0A452EHF8
names: Similarity
messages: Belongs to the WD repeat THOC6 family.

9925:ALG5
gene id: 9925:ALG5
uniprot id: A0A452ESM5
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

9925:TUBA8
gene id: 9925:TUBA8
uniprot id: A0A452FRB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains (PubMed:6504138, PubMed:2207090, PubMed:7704569). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:6504138, PubMed:2207090, PubMed:7704569). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:6504138, PubMed:2207090, PubMed:7704569).
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9925:CCDC126
gene id: 9925:CCDC126
uniprot id: A0A452FX04
names: Subcellular Location Annotation
messages: Secreted

9925:GTF2E2
gene id: 9925:GTF2E2
uniprot id: A0A452FI96
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFIIE beta subunit family.
messages: Nucleus
messages: Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
messages: Tetramer of two alpha and two beta chains.

9925:FZD9
gene id: 9925:FZD9
uniprot id: A0A452DMA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor Fz/Smo family.
messages: Membrane

9925:TSEN2
gene id: 9925:TSEN2
uniprot id: A0A452EID7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA-intron endonuclease family.
messages: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.
messages: Nucleus

9925:LOC102177275
gene id: 9925:LOC102177275
uniprot id: A0A452E4U1
names: Similarity
messages: Belongs to the intermediate filament family.

9925:LOC108633258
gene id: 9925:LOC108633258
uniprot id: A0A452EMK2
names: Subcellular Location Annotation
messages: Membrane

9925:HOXB3
gene id: 9925:HOXB3
uniprot id: A0A452EJ22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9925:NDUFS4
gene id: 9925:NDUFS4
uniprot id: A0A452G117
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS4 subunit family.
messages: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.
messages: Mitochondrion inner membrane

9925:LOC108636632
gene id: 9925:LOC108636632
uniprot id: A0A452EBR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:MRPL52
gene id: 9925:MRPL52
uniprot id: A0A452EJR2
uniprot id: A0A8C2PHL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL52 family.
messages: Mitochondrion

9925:LOC102190429
gene id: 9925:LOC102190429
uniprot id: A0A452DTZ0
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS25 family.
messages: Component of the small ribosomal subunit.

9925:MAP3K6
gene id: 9925:MAP3K6
uniprot id: A0A452DR23
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

9925:NDEL1
gene id: 9925:NDEL1
uniprot id: A0A452FJB8
uniprot id: A0A452FK73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nudE family.
messages: centrosome
messages: kinetochore
messages: spindle

9925:NECTIN3
gene id: 9925:NECTIN3
uniprot id: A0A452F7Y4
names: Similarity
messages: Belongs to the nectin family.

9925:GLUL
gene id: 9925:GLUL
uniprot id: A0A452G2Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cell membrane
messages: Membrane
messages: Microsome
messages: Mitochondrion

9925:C10H14orf1
gene id: 9925:C10H14orf1
uniprot id: A0A452E5Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG28 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:MRPS5
gene id: 9925:MRPS5
uniprot id: A0A452FGN3
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

9925:NID2
gene id: 9925:NID2
uniprot id: A0A452F5Y3
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: basement membrane

9925:ARRDC2
gene id: 9925:ARRDC2
uniprot id: A0A452DUM9
uniprot id: A0A452DUP0
names: Similarity
messages: Belongs to the arrestin family.

9925:EXOSC3
gene id: 9925:EXOSC3
uniprot id: A0A452F4Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRP40 family.
messages: Cytoplasm
messages: nucleolus

9925:LOC102191110
gene id: 9925:LOC102191110
uniprot id: A0A452ESY8
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

9925:CAV3
gene id: 9925:CAV3
uniprot id: A0A452E251
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the caveolin family.
messages: Cell membrane
messages: Golgi apparatus membrane
messages: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.
messages: Membrane
messages: caveola

9925:IDE
gene id: 9925:IDE
uniprot id: A0A452EWG8
names: Similarity
messages: Belongs to the peptidase M16 family.

9925:MIXL1
gene id: 9925:MIXL1
uniprot id: A0A8C2PH41
names: Subcellular Location Annotation
messages: Nucleus

9925:SLC39A2
gene id: 9925:SLC39A2
uniprot id: E7E822
names: Subcellular Location Annotation
messages: Membrane

9925:ACTR5
gene id: 9925:ACTR5
uniprot id: A0A452E6E9
names: Similarity
messages: Belongs to the actin family.

9925:RGS5
gene id: 9925:RGS5
uniprot id: A0A452FPM6
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.

9925:SYNGR1
gene id: 9925:SYNGR1
uniprot id: A0A452F4G5
uniprot id: A0A452F510
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9925:TMEM251
gene id: 9925:TMEM251
uniprot id: A0A452FBW4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LYSET family.
messages: Membrane

9925:PFKM
gene id: 9925:PFKM
uniprot id: A0A452G4K3
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homo- and heterotetramers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:QKI
gene id: 9925:QKI
uniprot id: A0A452F789
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Homodimer. Does not require RNA to homodimerize. Able to heterodimerize with BICC1.
messages: Nucleus
messages: RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor.

9925:LOC102190537
gene id: 9925:LOC102190537
uniprot id: A0A452G3Y8
uniprot id: A0A8C2RUI3
names: Similarity
messages: Belongs to the MHC class I family.

9925:MAP6
gene id: 9925:MAP6
uniprot id: A0A452FUV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STOP family.
messages: cytoskeleton

9925:LOC102183346
gene id: 9925:LOC102183346
uniprot id: A0A452DSC0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:MOGAT1
gene id: 9925:MOGAT1
uniprot id: A0A452DS70
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:SLX4
gene id: 9925:SLX4
uniprot id: A0A452EYF1
uniprot id: A0A8C2R672
names: Similarity
messages: Belongs to the SLX4 family.

9925:PAPSS1
gene id: 9925:PAPSS1
uniprot id: A0A452DV72
names: Similarity
messages: In the C-terminal section; belongs to the sulfate adenylyltransferase family.
messages: In the N-terminal section; belongs to the APS kinase family.

9925:ATP1B1
gene id: 9925:ATP1B1
uniprot id: A0A452FU58
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the X(+)/potassium ATPases subunit beta family.
messages: Membrane
messages: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.

9925:LOC102183310
gene id: 9925:LOC102183310
uniprot id: A0A452DUR8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SERPINF1
gene id: 9925:SERPINF1
uniprot id: A0A452G7E7
names: Similarity
messages: Belongs to the serpin family.

9925:LOC102186727
gene id: 9925:LOC102186727
uniprot id: A0A452FMQ6
names: Similarity
messages: Belongs to the MHC class II family.

9925:SLC26A1
gene id: 9925:SLC26A1
uniprot id: A0A452DQE8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Sodium-independent sulfate anion transporter. Can transport other anions including bicarbonate, thiosulfate and oxalate.

9925:LOC102179515
gene id: 9925:LOC102179515
uniprot id: A0A452F6J7
names: Similarity
messages: Belongs to the intermediate filament family.

9925:LOC102180761
gene id: 9925:LOC102180761
uniprot id: A0A452E5Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:LOC102170976
gene id: 9925:LOC102170976
uniprot id: A0A452DXX6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:KIAA1191
gene id: 9925:KIAA1191
uniprot id: A0A452EIG9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the P33MONOX family.
messages: Cytoplasm
messages: Interacts with NELFB, NOL12 and PRNP.
messages: Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.

9925:KIF5B
gene id: 9925:KIF5B
uniprot id: A0A452F874
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9925:LOC102180889
gene id: 9925:LOC102180889
uniprot id: A0A452FPP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9925:ZNF706
gene id: 9925:ZNF706
uniprot id: A0A452DTV1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:LOC102185355
gene id: 9925:LOC102185355
uniprot id: A0A452DW53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ARL11
gene id: 9925:ARL11
uniprot id: A0A452DQA0
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9925:EIF3K
gene id: 9925:EIF3K
uniprot id: A0A452FS00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit K family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Nucleus

9925:LOC102180829
gene id: 9925:LOC102180829
uniprot id: A0A452ESP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase U48 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:CAMTA2
gene id: 9925:CAMTA2
uniprot id: A0A452E726
names: Similarity
names: Subunit
messages: Belongs to the CAMTA family.
messages: May interact with calmodulin.

9925:TRAPPC6A
gene id: 9925:TRAPPC6A
uniprot id: A0A8C2XZ57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAPP small subunits family. BET3 subfamily.
messages: Endoplasmic reticulum
messages: cis-Golgi network

9925:SSBP3
gene id: 9925:SSBP3
uniprot id: A0A452FW80
uniprot id: A0A452FX13
names: Subcellular Location Annotation
messages: Nucleus

9925:CLCN7
gene id: 9925:CLCN7
uniprot id: A0A452EUI5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel (TC 2.A.49) family.
messages: Membrane

9925:HNRNPDL
gene id: 9925:HNRNPDL
uniprot id: A0A452E357
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:LOC102180319
gene id: 9925:LOC102180319
uniprot id: A0A452DWW3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:FDXR
gene id: 9925:FDXR
uniprot id: A0A452EV68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferredoxin--NADP reductase type 1 family.
messages: Mitochondrion
messages: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.

9925:COG8
gene id: 9925:COG8
uniprot id: A0A452FLJ5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the COG8 family.
messages: Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.
messages: Golgi apparatus membrane
messages: Membrane

9925:S1PR2
gene id: 9925:S1PR2
uniprot id: A0A452E2Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:VTA1
gene id: 9925:VTA1
uniprot id: A0A452FL63
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VTA1 family.
messages: Cytoplasm
messages: Endosome membrane
messages: Membrane

9925:TNF
gene id: 9925:TNF
uniprot id: P13296
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity). Promotes osteoclastogenesis and therefore mediates bone resorption (By similarity).
messages: Homotrimer. Interacts with SPPL2B (By similarity).
messages: Membrane
messages: O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
messages: Secreted
messages: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
messages: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity).
messages: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space (By similarity).
messages: The soluble form is demyristoylated by SIRT6, promoting its secretion.

9925:EDEM1
gene id: 9925:EDEM1
uniprot id: A0A452E774
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9925:CPNE8
gene id: 9925:CPNE8
uniprot id: A0A452G7D8
names: Similarity
messages: Belongs to the copine family.

9925:MAPKAP1
gene id: 9925:MAPKAP1
uniprot id: A0A452G8W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SIN1 family.
messages: Cytoplasmic vesicle

9925:PSMD12
gene id: 9925:PSMD12
uniprot id: A0A452G300
names: Similarity
messages: Belongs to the proteasome subunit p55 family.

9925:SCP2
gene id: 9925:SCP2
uniprot id: A0A452DRP4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. Thiolase family.
messages: Cytoplasm
messages: Interacts with PEX5; the interaction is essential for peroxisomal import.
messages: Mitochondrion

9925:PRR15
gene id: 9925:PRR15
uniprot id: A0A452E479
names: Similarity
messages: Belongs to the PRR15 family.

9925:LOC102176457
gene id: 9925:LOC102176457
uniprot id: A0A452F292
names: Similarity
messages: Belongs to the intermediate filament family.

9925:LOC102171808
gene id: 9925:LOC102171808
uniprot id: A0A452E3R9
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9925:PPARG
gene id: 9925:PPARG
uniprot id: H6WNB0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Heterodimer with other nuclear receptors.
messages: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
messages: Nucleus

9925:ENTPD7
gene id: 9925:ENTPD7
uniprot id: A0A452E4C7
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9925:RBM17
gene id: 9925:RBM17
uniprot id: A0A452FSJ2
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the spliceosome.
messages: Nucleus
messages: Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.

9925:DTNA
gene id: 9925:DTNA
uniprot id: A0A452EI67
uniprot id: A0A452EIE1
uniprot id: A0A452EIG6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

9925:LOC102181965
gene id: 9925:LOC102181965
uniprot id: A0A8C2NQK6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.
messages: Belongs to the IL-1 family.
messages: Secreted

9925:TEKT2
gene id: 9925:TEKT2
uniprot id: A0A452G951
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tektin family.
messages: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.
messages: flagellum

9925:MOV10
gene id: 9925:MOV10
uniprot id: A0A452FNR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.
messages: P-body

9925:SEC13
gene id: 9925:SEC13
uniprot id: A0A452EQU0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat SEC13 family.
messages: Lysosome membrane

9925:HAPLN1
gene id: 9925:HAPLN1
uniprot id: A0A452FU44
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:TMEM17
gene id: 9925:TMEM17
uniprot id: A0A452ECZ9
names: Subcellular Location Annotation
messages: Membrane

9925:ATP5J
gene id: 9925:ATP5J
uniprot id: A0A452FLK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic ATPase subunit F6 family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.
messages: Mitochondrion
messages: Mitochondrion inner membrane

9925:KNG1
gene id: 9925:KNG1
uniprot id: A0A452E819
names: Subcellular Location Annotation
messages: extracellular space

9925:LLGL1
gene id: 9925:LLGL1
uniprot id: A0A452ENM0
names: Similarity
messages: Belongs to the WD repeat L(2)GL family.

9925:LOC102177429
gene id: 9925:LOC102177429
uniprot id: A0A8C2R433
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PTPRCAP
gene id: 9925:PTPRCAP
uniprot id: A0A452E0C6
names: Subcellular Location Annotation
names: Subunit
messages: Interacts with CD45/PTPRC.
messages: Membrane

9925:ZNRF3
gene id: 9925:ZNRF3
uniprot id: A0A452E7P7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZNRF3 family.
messages: Cell membrane

9925:DNAJC16
gene id: 9925:DNAJC16
uniprot id: A0A452ESS6
names: Function
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Plays an important role in regulating the size of autophagosomes during the formation process.

9925:IDH3A
gene id: 9925:IDH3A
uniprot id: A0A452EKB7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the isocitrate and isopropylmalate dehydrogenases family.
messages: Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.
messages: Mitochondrion

9925:SMYD2
gene id: 9925:SMYD2
uniprot id: A0A452F760
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
messages: cytosol

9925:ELOVL7
gene id: 9925:ELOVL7
uniprot id: A0A452DNN6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL7 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: The C-terminal di-lysine motif may confer endoplasmic reticulum localization.

9925:MLH1
gene id: 9925:MLH1
uniprot id: A0A452EAM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: Nucleus

9925:KPNA3
gene id: 9925:KPNA3
uniprot id: A0A452FEC0
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9925:YIPF5
gene id: 9925:YIPF5
uniprot id: A0A452F7L1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YIP1 family.
messages: Membrane

9925:LOC108636735
gene id: 9925:LOC108636735
uniprot id: A0A452DR12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the KRTAP type 6 family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9925:RARRES2
gene id: 9925:RARRES2
uniprot id: A0A0K0QVA4
names: Subcellular Location Annotation
messages: Secreted

9925:LOC102181861
gene id: 9925:LOC102181861
uniprot id: A0A452EH91
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102188021
gene id: 9925:LOC102188021
uniprot id: A0A452FWH6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIII family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits MT-CO1, MT-CO2 and MT-CO3, encoded in the mitochondrial DNA, and 11 supernumerary subunits COX4I, COX5A, COX5B, COX6A, COX6B, COX6C, COX7A, COX7B, COX7C, COX8 and NDUFA4, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9925:TMED5
gene id: 9925:TMED5
uniprot id: A0A452EU71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9925:HOXC10
gene id: 9925:HOXC10
uniprot id: A0A452DTC4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9925:FAM167B
gene id: 9925:FAM167B
uniprot id: A0A452FY27
names: Similarity
messages: Belongs to the FAM167 (SEC) family.

9925:PSMA8
gene id: 9925:PSMA8
uniprot id: A0A452F784
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase T1A family.
messages: Nucleus

9925:LOC102185760
gene id: 9925:LOC102185760
uniprot id: A0A452DQ34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC108638292
gene id: 9925:LOC108638292
uniprot id: A0A452E4X2
names: Function
messages: The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulfur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa).

9925:RALYL
gene id: 9925:RALYL
uniprot id: A0A8C2R353
names: Similarity
messages: Belongs to the RRM HNRPC family. RALY subfamily.

9925:STX12
gene id: 9925:STX12
uniprot id: A0A452FXY3
names: Similarity
messages: Belongs to the syntaxin family.

9925:FOXE1
gene id: 9925:FOXE1
uniprot id: A0A452DS04
names: Subcellular Location Annotation
messages: Nucleus

9925:ARRDC3
gene id: 9925:ARRDC3
uniprot id: A0A452G7C3
names: Similarity
messages: Belongs to the arrestin family.

9925:HSCB
gene id: 9925:HSCB
uniprot id: A0A452G4V6
names: Similarity
messages: Belongs to the HscB family.

9925:HMGCS2
gene id: 9925:HMGCS2
uniprot id: D4P8J3
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
messages: Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

9925:DMRTA2
gene id: 9925:DMRTA2
uniprot id: A0A452EK21
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9925:DTD2
gene id: 9925:DTD2
uniprot id: A0A452E953
names: Similarity
messages: Belongs to the DTD family.

9925:LOC102174423
gene id: 9925:LOC102174423
uniprot id: A0A452DRJ2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mis12 family.
messages: Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.
messages: kinetochore

9925:FASLG
gene id: 9925:FASLG
uniprot id: X2KPF1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Cell membrane
messages: Cytoplasmic form induces gene transcription inhibition.
messages: Cytoplasmic vesicle lumen
messages: Lysosome lumen
messages: Nucleus
messages: Secreted

9925:DDO
gene id: 9925:DDO
uniprot id: A0A452DMZ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DAMOX/DASOX family.
messages: Peroxisome

9925:KCNA10
gene id: 9925:KCNA10
uniprot id: A0A452E3W6
names: Subcellular Location Annotation
messages: Membrane

9925:MRPS27
gene id: 9925:MRPS27
uniprot id: A0A452G0S6
names: Subcellular Location Annotation
messages: Mitochondrion

9925:ELF3
gene id: 9925:ELF3
uniprot id: A0A452E5R8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9925:LOC102189227
gene id: 9925:LOC102189227
uniprot id: A0A452EGG4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PGK2
gene id: 9925:PGK2
uniprot id: A0A452DPV3
names: Similarity
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Monomer.

9925:GNGT2
gene id: 9925:GNGT2
uniprot id: A0A452FPU4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9925:DLGAP4
gene id: 9925:DLGAP4
uniprot id: A0A452FN86
uniprot id: A0A452FN89
uniprot id: A0A8C2SE19
uniprot id: A0A8C2SEY0
names: Similarity
messages: Belongs to the SAPAP family.

9925:NOSTRIN
gene id: 9925:NOSTRIN
uniprot id: A0A452EC67
names: Subcellular Location Annotation
messages: cytoskeleton

9925:ACTL10
gene id: 9925:ACTL10
uniprot id: A0A452DN44
names: Similarity
messages: Belongs to the actin family.

9925:DOCK5
gene id: 9925:DOCK5
uniprot id: A0A452DMY2
names: Similarity
messages: Belongs to the DOCK family.

9925:SDPR
gene id: 9925:SDPR
uniprot id: A0A452FAV0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAVIN family.
messages: caveola

9925:HSD17B2
gene id: 9925:HSD17B2
uniprot id: A0A452DN30
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:CYR61
gene id: 9925:CYR61
uniprot id: A0A452GBG4
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCN family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:GPR6
gene id: 9925:GPR6
uniprot id: A0A452E1Z2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:LSM6
gene id: 9925:LSM6
uniprot id: A0A452E3D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.
messages: Nucleus

9925:LOC102180307
gene id: 9925:LOC102180307
uniprot id: A0A452DWU1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H4 family.
messages: Chromosome
messages: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:SMG6
gene id: 9925:SMG6
uniprot id: A0A452FLF5
names: Domain
names: Function
names: Subcellular Location Annotation
messages: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini.
messages: Plays a role in nonsense-mediated mRNA decay.
messages: The PINc domain confers endonuclease activity and is expected to bind the catalytic metal ion.
messages: cytosol
messages: nucleolus
messages: telomere

9925:FUT4
gene id: 9925:FUT4
uniprot id: A0A452EGX4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 10 family.
messages: Golgi stack membrane

9925:SAR1A
gene id: 9925:SAR1A
uniprot id: A0A452F730
names: Similarity
messages: Belongs to the small GTPase superfamily. SAR1 family.

9925:ANKRD13C
gene id: 9925:ANKRD13C
uniprot id: A0A452FIT2
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102187417
gene id: 9925:LOC102187417
uniprot id: A0A452DQL3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:IP6K2
gene id: 9925:IP6K2
uniprot id: A0A452EWA7
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9925:GHITM
gene id: 9925:GHITM
uniprot id: A9LLG2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

9925:TMEM59
gene id: 9925:TMEM59
uniprot id: A0A452E410
uniprot id: A0A452E420
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM59 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:GPR4
gene id: 9925:GPR4
uniprot id: A0A452DRU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:SERPINB7
gene id: 9925:SERPINB7
uniprot id: A0A452DT10
names: Similarity
messages: Belongs to the serpin family.

9925:CHRM2
gene id: 9925:CHRM2
uniprot id: A0A452DPN3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.

9925:WNT7B
gene id: 9925:WNT7B
uniprot id: A0A452ELQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9925:MYLK4
gene id: 9925:MYLK4
uniprot id: A0A452DVZ5
uniprot id: A0A452DW64
uniprot id: A0A452DW74
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:LOC102175174
gene id: 9925:LOC102175174
uniprot id: A0A452DKU2
names: Subcellular Location Annotation
messages: Nucleus

9925:LHCGR
gene id: 9925:LHCGR
uniprot id: A0A0G2YFV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Membrane
messages: Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

9925:ZKSCAN4
gene id: 9925:ZKSCAN4
uniprot id: A0A452ECB6
names: Subcellular Location Annotation
messages: Nucleus

9925:CA3
gene id: 9925:CA3
uniprot id: A0A452ECP7
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9925:VIPR1
gene id: 9925:VIPR1
uniprot id: A0A452FIH0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9925:PADI1
gene id: 9925:PADI1
uniprot id: A0A452F6C0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein arginine deiminase family.
messages: Catalyzes the deimination of arginine residues of proteins.
messages: Cytoplasm

9925:ABCC11
gene id: 9925:ABCC11
uniprot id: A0A452DMT8
names: Subcellular Location Annotation
messages: Membrane

9925:DOK1
gene id: 9925:DOK1
uniprot id: A0A452G6U1
names: Similarity
messages: Belongs to the DOK family. Type A subfamily.

9925:CNP
gene id: 9925:CNP
uniprot id: A0A452DU53
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 2H phosphoesterase superfamily. CNPase family.
messages: Exists as monomers and homodimers.
messages: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.
messages: Melanosome
messages: Membrane

9925:DPH6
gene id: 9925:DPH6
uniprot id: A0A452G2F4
uniprot id: A0A8C2NL28
names: Function
names: Similarity
messages: Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.
messages: Belongs to the Diphthine--ammonia ligase family.

9925:TPD52L2
gene id: 9925:TPD52L2
uniprot id: A0A452FHN5
names: Similarity
messages: Belongs to the TPD52 family.

9925:TLR1
gene id: 9925:TLR1
uniprot id: F1CGU1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane
messages: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides.

9925:PPM1N
gene id: 9925:PPM1N
uniprot id: A0A8C2RX97
names: Similarity
messages: Belongs to the PP2C family.

9925:SLC25A34
gene id: 9925:SLC25A34
uniprot id: A0A8C2S0X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:PKIA
gene id: 9925:PKIA
uniprot id: A0A452FQ82
names: Function
names: Similarity
messages: Belongs to the PKI family.
messages: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

9925:PKMYT1
gene id: 9925:PKMYT1
uniprot id: A0A452E9Q4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:TM9SF2
gene id: 9925:TM9SF2
uniprot id: A0A452E1Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
messages: Membrane

9925:DDB1
gene id: 9925:DDB1
uniprot id: A0A452ENH1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DDB1 family.
messages: Component of complexes involved in DNA repair and protein ubiquitination. May play a role in the regulation of the circadian clock.
messages: Component of the UV-DDB complex.
messages: Nucleus
messages: The core of the protein consists of three WD40 beta-propeller domains.

9925:SLC39A1
gene id: 9925:SLC39A1
uniprot id: A0A452E9K3
uniprot id: F4ZW67
names: Subcellular Location Annotation
messages: Membrane

9925:MFNG
gene id: 9925:MFNG
uniprot id: A0A452DYF8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:MCUB
gene id: 9925:MCUB
uniprot id: A0A452EAA8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCU (TC 1.A.77) family.
messages: Membrane
messages: Mitochondrion inner membrane

9925:LOC102174001
gene id: 9925:LOC102174001
uniprot id: A0A452E915
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TBX20
gene id: 9925:TBX20
uniprot id: A0A452E768
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9925:FAM131C
gene id: 9925:FAM131C
uniprot id: A0A452ELN4
names: Similarity
messages: Belongs to the FAM131 family.

9925:RPL23
gene id: 9925:RPL23
uniprot id: A0A452EU40
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Component of the large ribosomal subunit.

9925:LOC106502686
gene id: 9925:LOC106502686
uniprot id: A0A452DS19
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9925:IRAK1BP1
gene id: 9925:IRAK1BP1
uniprot id: A0A452F3F2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IRAK1BP1 family.
messages: Cytoplasm
messages: Nucleus

9925:RBM15
gene id: 9925:RBM15
uniprot id: A0A452G9D3
names: Similarity
messages: Belongs to the RRM Spen family.

9925:LOC102184403
gene id: 9925:LOC102184403
uniprot id: A0A452DUL1
names: Similarity
messages: Belongs to the TCAF family.

9925:METTL8
gene id: 9925:METTL8
uniprot id: A0A452EN94
names: Function
names: Similarity
messages: Belongs to the methyltransferase superfamily. METL family.
messages: S-adenosyl-L-methionine-dependent methyltransferase.

9925:AARS
gene id: 9925:AARS
uniprot id: A0A452ESX0
names: Cofactor
names: Domain
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: ISGylated.
messages: Monomer. Interacts with ANKRD16; the interaction is direct.

9925:GOLM1
gene id: 9925:GOLM1
uniprot id: A0A452FQ55
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GOLM family.
messages: Membrane

9925:LNPK
gene id: 9925:LNPK
uniprot id: A0A452EC74
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the lunapark family.
messages: Endoplasmic reticulum membrane
messages: Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.
messages: Plays a role in determining ER morphology.
messages: The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.

9925:PROSC
gene id: 9925:PROSC
uniprot id: A0A452FU89
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.

9925:SCAMP4
gene id: 9925:SCAMP4
uniprot id: A0A452G8R5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9925:ID1
gene id: 9925:ID1
uniprot id: A0A452E6S0
names: Subcellular Location Annotation
messages: Nucleus

9925:RUNX2
gene id: 9925:RUNX2
uniprot id: A0A452ETJ7
uniprot id: A0A452EU36
uniprot id: A0A452EU42
names: Function
names: Subcellular Location Annotation
messages: Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.
messages: Nucleus

9925:ORMDL1
gene id: 9925:ORMDL1
uniprot id: A0A452EH98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9925:CMBL
gene id: 9925:CMBL
uniprot id: A0A452FU60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dienelactone hydrolase family.
messages: cytosol

9925:IPMK
gene id: 9925:IPMK
uniprot id: A0A452F0B4
uniprot id: A0A8C2RXJ1
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9925:RBM5
gene id: 9925:RBM5
uniprot id: A0A452F4Y6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RBM5/RBM10 family.
messages: Nucleus

9925:TNRC6A
gene id: 9925:TNRC6A
uniprot id: A0A452F9Z0
names: Similarity
messages: Belongs to the GW182 family.

9925:MEGF11
gene id: 9925:MEGF11
uniprot id: A0A452FS42
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:HOXA6
gene id: 9925:HOXA6
uniprot id: A0A452ER78
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9925:CACNG2
gene id: 9925:CACNG2
uniprot id: A0A452E8D5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
messages: Membrane
messages: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.

9925:EMP2
gene id: 9925:EMP2
uniprot id: A0A452E9P4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the PMP-22/EMP/MP20 family.
messages: Cell membrane
messages: Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion.
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Membrane raft
messages: Nucleus
messages: perinuclear region

9925:FAM76A
gene id: 9925:FAM76A
uniprot id: A0A452E2K4
names: Similarity
messages: Belongs to the FAM76 family.

9925:SLC17A3
gene id: 9925:SLC17A3
uniprot id: A0A452FDU6
names: Subcellular Location Annotation
messages: Membrane

9925:KIAA1324
gene id: 9925:KIAA1324
uniprot id: A0A452FUZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELAPOR family.
messages: Cell membrane
messages: Membrane

9925:CHRM5
gene id: 9925:CHRM5
uniprot id: A0A452E3M5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9925:NME6
gene id: 9925:NME6
uniprot id: A0A452G753
names: Similarity
messages: Belongs to the NDK family.

9925:LOC102168812
gene id: 9925:LOC102168812
uniprot id: A0A452EKY4
names: Similarity
messages: Belongs to the peptidase A1 family.

9925:SCN3B
gene id: 9925:SCN3B
uniprot id: A0A452DS24
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
messages: Membrane
messages: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.

9925:HCN4
gene id: 9925:HCN4
uniprot id: A0A452E8B9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the potassium channel HCN family.
messages: Cell membrane
messages: Membrane

9925:DTX2
gene id: 9925:DTX2
uniprot id: A0A452EIN4
uniprot id: A0A452EIP7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9925:RDH12
gene id: 9925:RDH12
uniprot id: A0A452G7T2
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:PLPP4
gene id: 9925:PLPP4
uniprot id: A0A452EI90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9925:MEP1B
gene id: 9925:MEP1B
uniprot id: A0A452DL84
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:FRG1
gene id: 9925:FRG1
uniprot id: A0A452E8P1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FRG1 family.
messages: Cajal body
messages: nucleolus

9925:SUCNR1
gene id: 9925:SUCNR1
uniprot id: A0A452DVW0
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:PARD6A
gene id: 9925:PARD6A
uniprot id: A0A452DVD2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

9925:LOC108636448
gene id: 9925:LOC108636448
uniprot id: A0A452DU27
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:FAM175A
gene id: 9925:FAM175A
uniprot id: A0A452EWB2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM175 family. Abraxas subfamily.
messages: Nucleus

9925:GPAM
gene id: 9925:GPAM
uniprot id: A0A452FEF6
uniprot id: A0A452FEM6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPAT/DAPAT family.
messages: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.
messages: Mitochondrion outer membrane

9925:SLC25A22
gene id: 9925:SLC25A22
uniprot id: A0A452EHP1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:TAF1D
gene id: 9925:TAF1D
uniprot id: A0A452G7H4
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.
messages: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.
messages: Nucleus

9925:LOC102175171
gene id: 9925:LOC102175171
uniprot id: A0A452EXA4
names: Similarity
messages: Belongs to the GST superfamily. Alpha family.

9925:LOC102181592
gene id: 9925:LOC102181592
uniprot id: A0A452FQ25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CALHM family.
messages: Membrane

9925:ZDHHC16
gene id: 9925:ZDHHC16
uniprot id: A0A452FYM8
uniprot id: A0A452FZC6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9925:FHL5
gene id: 9925:FHL5
uniprot id: A0A452E5C1
names: Function
names: Subcellular Location Annotation
messages: May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.
messages: Nucleus

9925:SLC48A1
gene id: 9925:SLC48A1
uniprot id: A0A452EBG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HRG family.
messages: Endosome membrane
messages: Membrane
messages: phagosome membrane

9925:USP44
gene id: 9925:USP44
uniprot id: A0A452DP71
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9925:LOC102177790
gene id: 9925:LOC102177790
uniprot id: A0A452DZJ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:CAMK4
gene id: 9925:CAMK4
uniprot id: A0A452EA99
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:LOC102189595
gene id: 9925:LOC102189595
uniprot id: A0A452FKK5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.

9925:SLC35F4
gene id: 9925:SLC35F4
uniprot id: A0A8C2NWL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9925:RHPN2
gene id: 9925:RHPN2
uniprot id: A0A452E2S5
names: Similarity
messages: Belongs to the RHPN family.

9925:GRHL3
gene id: 9925:GRHL3
uniprot id: A0A452F7N1
names: Subcellular Location Annotation
messages: Nucleus

9925:MORF4L1
gene id: 9925:MORF4L1
uniprot id: A0A452DY88
uniprot id: A0A452DYU9
names: Subcellular Location Annotation
messages: Nucleus

9925:BOD1
gene id: 9925:BOD1
uniprot id: A0A452FIY0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BOD1 family.
messages: centrosome
messages: kinetochore

9925:VEGFA
gene id: 9925:VEGFA
uniprot id: A0A024DAZ8
uniprot id: K4P986
names: Similarity
messages: Belongs to the PDGF/VEGF growth factor family.

9925:UCN2
gene id: 9925:UCN2
uniprot id: A0A452DTN9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

9925:FAM83A
gene id: 9925:FAM83A
uniprot id: A0A452E699
names: Similarity
messages: Belongs to the FAM83 family.

9925:LOC108633262
gene id: 9925:LOC108633262
uniprot id: A0A452FDX9
names: Similarity
messages: Belongs to the intermediate filament family.

9925:WDR24
gene id: 9925:WDR24
uniprot id: A0A452FM91
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the WD repeat WDR24 family.
messages: Lysosome membrane

9925:CNPY1
gene id: 9925:CNPY1
uniprot id: A0A452E798
names: Similarity
messages: Belongs to the canopy family.

9925:LOC108637965
gene id: 9925:LOC108637965
uniprot id: A0A452FAK0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:SLC19A2
gene id: 9925:SLC19A2
uniprot id: A0A452EDL0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
messages: Cell membrane
messages: High-affinity transporter for the intake of thiamine.

9925:FAM3C
gene id: 9925:FAM3C
uniprot id: A0A452G8V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM3 family.
messages: Secreted

9925:ZUFSP
gene id: 9925:ZUFSP
uniprot id: A0A452FR06
names: Similarity
names: Subunit
messages: Belongs to the peptidase C78 family. ZUFSP subfamily.
messages: Interacts with RPA1 and RPA2.

9925:LOC102186170
gene id: 9925:LOC102186170
uniprot id: A0A452E691
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:HYAL2
gene id: 9925:HYAL2
uniprot id: A0A452DVX5
names: Similarity
messages: Belongs to the glycosyl hydrolase 56 family.

9925:SLC18A2
gene id: 9925:SLC18A2
uniprot id: A0A452FWY0
names: Subcellular Location Annotation
messages: Membrane

9925:TMEM145
gene id: 9925:TMEM145
uniprot id: A0A452DPF7
names: Subcellular Location Annotation
messages: Membrane

9925:RPP14
gene id: 9925:RPP14
uniprot id: A0A452F9G4
names: Similarity
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

9925:PIK3R1
gene id: 9925:PIK3R1
uniprot id: A0A452FGW5
uniprot id: A0A452FHR1
names: Similarity
messages: Belongs to the PI3K p85 subunit family.

9925:PHF20
gene id: 9925:PHF20
uniprot id: A0A452EWV9
names: Subcellular Location Annotation
messages: Nucleus

9925:ALX1
gene id: 9925:ALX1
uniprot id: A0A452G2P5
names: Subcellular Location Annotation
messages: Nucleus

9925:POU2F3
gene id: 9925:POU2F3
uniprot id: A0A452EZP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-2 subfamily.
messages: Nucleus

9925:XKR7
gene id: 9925:XKR7
uniprot id: A0A452GA50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XK family.
messages: Membrane

9925:ATP7B
gene id: 9925:ATP7B
uniprot id: A0A452FW69
uniprot id: A0A452FX39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Membrane
messages: trans-Golgi network membrane

9925:HK2
gene id: 9925:HK2
uniprot id: A0A452ECG9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hexokinase family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: cytosol

9925:LOC102170675
gene id: 9925:LOC102170675
uniprot id: A0A452EFI0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SLC9A3
gene id: 9925:SLC9A3
uniprot id: A0A452FGZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
messages: Cell membrane
messages: Membrane
messages: Recycling endosome membrane

9925:BAP1
gene id: 9925:BAP1
uniprot id: A0A452FLD0
names: Similarity
messages: Belongs to the peptidase C12 family.

9925:QTRT1
gene id: 9925:QTRT1
uniprot id: A0A452EKD3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.
messages: Cytoplasm
messages: Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.
messages: Mitochondrion outer membrane

9925:RC3H2
gene id: 9925:RC3H2
uniprot id: A0A452F967
names: Subcellular Location Annotation
messages: P-body

9925:LOC102174969
gene id: 9925:LOC102174969
uniprot id: A0A452FC76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9925:LOC102174428
gene id: 9925:LOC102174428
uniprot id: A0A452FZ07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCO1/2 family.
messages: Mitochondrion inner membrane

9925:ZNRF4
gene id: 9925:ZNRF4
uniprot id: A0A8C2P9F3
names: Subcellular Location Annotation
messages: Membrane

9925:DDX10
gene id: 9925:DDX10
uniprot id: A0A452EQ78
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9925:LCLAT1
gene id: 9925:LCLAT1
uniprot id: A0A452FQD4
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9925:TMEM126B
gene id: 9925:TMEM126B
uniprot id: A0A452EF70
names: Subcellular Location Annotation
messages: Membrane

9925:CDA
gene id: 9925:CDA
uniprot id: A0A452GAK9
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

9925:LOC102168981
gene id: 9925:LOC102168981
uniprot id: A0A452E8J0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CTSS
gene id: 9925:CTSS
uniprot id: A0A452FQB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C1 family.
messages: Lysosome

9925:GBA
gene id: 9925:GBA
uniprot id: A0A8C2N4S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyl hydrolase 30 family.
messages: Lysosome membrane

9925:AK1
gene id: 9925:AK1
uniprot id: A0A452E712
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK1 subfamily.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Monomer.

9925:PIGS
gene id: 9925:PIGS
uniprot id: A0A452F1F1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PIGS family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:EIF4A2
gene id: 9925:EIF4A2
uniprot id: A0A452EBN6
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9925:MSRA
gene id: 9925:MSRA
uniprot id: A0A8C2NNE4
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.

9925:FGFR1
gene id: 9925:FGFR1
uniprot id: A0A452E6E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Membrane
messages: Nucleus
messages: Vesicle
messages: cytosol

9925:GOSR1
gene id: 9925:GOSR1
uniprot id: A0A452FAA5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GOSR1 family.
messages: Component of several multiprotein Golgi SNARE complexes.
messages: Golgi apparatus membrane
messages: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.
messages: Membrane

9925:NME3
gene id: 9925:NME3
uniprot id: A0A452FGI6
names: Similarity
messages: Belongs to the NDK family.

9925:TPX2
gene id: 9925:TPX2
uniprot id: A0A452FVK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TPX2 family.
messages: Nucleus
messages: spindle pole

9925:RTFDC1
gene id: 9925:RTFDC1
uniprot id: A0A452EXA5
names: Similarity
names: Subunit
messages: Belongs to the rtf2 family.
messages: Interacts with DDI2; probably also interacts with DDI1.

9925:ERCC4
gene id: 9925:ERCC4
uniprot id: A0A452FPB0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPF family.
messages: Nucleus

9925:SCOC
gene id: 9925:SCOC
uniprot id: A0A452FX29
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCOC family.
messages: Positive regulator of amino acid starvation-induced autophagy.
messages: trans-Golgi network

9925:FYN
gene id: 9925:FYN
uniprot id: A0A452DZ83
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9925:AP2B1
gene id: 9925:AP2B1
uniprot id: A0A452F9D0
uniprot id: A0A452F9H7
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9925:LOC102185363
gene id: 9925:LOC102185363
uniprot id: A0A452EZ92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LEG1 family.
messages: Secreted

9925:KCNQ4
gene id: 9925:KCNQ4
uniprot id: A0A452ELV0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:LOC102173049
gene id: 9925:LOC102173049
uniprot id: A0A452E2R6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cathelicidin family.
messages: Secreted

9925:ARL6IP4
gene id: 9925:ARL6IP4
uniprot id: A0A452ELA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ARL6IP4 family.
messages: Nucleus speckle
messages: nucleolus

9925:CSNK1D
gene id: 9925:CSNK1D
uniprot id: A0A452EAE6
uniprot id: A0A452EAF0
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:CREBL2
gene id: 9925:CREBL2
uniprot id: A0A8C2NC70
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. ATF subfamily.
messages: Nucleus

9925:RDH10
gene id: 9925:RDH10
uniprot id: A0A452EW84
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:MRPL32
gene id: 9925:MRPL32
uniprot id: A0A452G652
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

9925:LOC102176061
gene id: 9925:LOC102176061
uniprot id: A0A452EGQ2
names: Similarity
messages: Belongs to the glycine N-acyltransferase family.

9925:TMEFF1
gene id: 9925:TMEFF1
uniprot id: A0A452EYM0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:DUSP1
gene id: 9925:DUSP1
uniprot id: A0A452FKQ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
messages: Nucleus

9925:GPR137C
gene id: 9925:GPR137C
uniprot id: A0A452FAK8
names: Subcellular Location Annotation
messages: Lysosome membrane
messages: Membrane

9925:RPRD1A
gene id: 9925:RPRD1A
uniprot id: A0A452F794
uniprot id: A0A452F842
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with the RNA polymerase II complex.
messages: Belongs to the UPF0400 (RTT103) family.
messages: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.
messages: Nucleus

9925:IMPA2
gene id: 9925:IMPA2
uniprot id: A0A452FQ77
names: Similarity
messages: Belongs to the inositol monophosphatase superfamily.

9925:UBAP2L
gene id: 9925:UBAP2L
uniprot id: A0A452FJR3
uniprot id: A0A452FKJ1
names: Subcellular Location Annotation
messages: Cytoplasm

9925:LOC102172897
gene id: 9925:LOC102172897
uniprot id: A0A452EM77
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9925:LOC102175435
gene id: 9925:LOC102175435
uniprot id: A0A452DMJ1
names: Subcellular Location Annotation
messages: Membrane

9925:RTCA
gene id: 9925:RTCA
uniprot id: A0A452F710
names: Function
names: Similarity
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.

9925:ING4
gene id: 9925:ING4
uniprot id: A0A452G205
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9925:CEBPZ
gene id: 9925:CEBPZ
uniprot id: A0A452FFL1
names: Similarity
messages: Belongs to the CBF/MAK21 family.

9925:CRYL1
gene id: 9925:CRYL1
uniprot id: A0A452FC66
names: Similarity
messages: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

9925:GFRA2
gene id: 9925:GFRA2
uniprot id: A0A452EVB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GDNFR family.
messages: Cell membrane
messages: Membrane
messages: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.

9925:IFRD1
gene id: 9925:IFRD1
uniprot id: A0A452EZS8
names: Similarity
messages: Belongs to the IFRD family.

9925:POU6F1
gene id: 9925:POU6F1
uniprot id: A0A452G7A9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9925:NT5E
gene id: 9925:NT5E
uniprot id: A0A452E4U4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 5'-nucleotidase family.
messages: Membrane

9925:GAL3ST1
gene id: 9925:GAL3ST1
uniprot id: A0A452E4H9
names: Similarity
messages: Belongs to the galactose-3-O-sulfotransferase family.

9925:TM6SF2
gene id: 9925:TM6SF2
uniprot id: A0A452DZS4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TM6SF family.
messages: Membrane

9925:STRIP1
gene id: 9925:STRIP1
uniprot id: A0A452EBP8
names: Similarity
messages: Belongs to the STRIP family.

9925:CASP3
gene id: 9925:CASP3
uniprot id: H9B8T7
names: Similarity
messages: Belongs to the peptidase C14A family.

9925:ETHE1
gene id: 9925:ETHE1
uniprot id: A0A452EI23
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9925:CD38
gene id: 9925:CD38
uniprot id: A0A452DQ25
names: Similarity
messages: Belongs to the ADP-ribosyl cyclase family.

9925:IL1RL2
gene id: 9925:IL1RL2
uniprot id: A0A452G585
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9925:PPIL4
gene id: 9925:PPIL4
uniprot id: A0A452E4I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.
messages: Nucleus
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9925:LPAR3
gene id: 9925:LPAR3
uniprot id: A0A452EZM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:ALDOC
gene id: 9925:ALDOC
uniprot id: A0A452DZ43
names: Similarity
messages: Belongs to the class I fructose-bisphosphate aldolase family.

9925:LOC102168270
gene id: 9925:LOC102168270
uniprot id: A0A452FUH0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 6 family.
messages: Binds 1 Mn(2+) ion per subunit.
messages: Membrane

9925:EOGT
gene id: 9925:EOGT
uniprot id: A0A452EJR1
names: Similarity
messages: Belongs to the glycosyltransferase 61 family.

9925:PSPH
gene id: 9925:PSPH
uniprot id: A0A452DYB1
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily. SerB family.

9925:ADTRP
gene id: 9925:ADTRP
uniprot id: A0A452G3X1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIG1 family.
messages: Membrane

9925:LOC102189778
gene id: 9925:LOC102189778
uniprot id: A0A452E1H3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:EHD4
gene id: 9925:EHD4
uniprot id: A0A452G1I9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9925:PGAP1
gene id: 9925:PGAP1
uniprot id: A0A452F4I0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GPI inositol-deacylase family.
messages: Endoplasmic reticulum membrane
messages: Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.
messages: Membrane

9925:MSX1
gene id: 9925:MSX1
uniprot id: A0A452EK01
names: Subcellular Location Annotation
messages: Nucleus

9925:ELF2
gene id: 9925:ELF2
uniprot id: A0A452F4W1
uniprot id: A0A452F4X3
uniprot id: A0A452F4Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9925:NOC2L
gene id: 9925:NOC2L
uniprot id: A0A452EYW0
names: Similarity
messages: Belongs to the NOC2 family.

9925:TSHB
gene id: 9925:TSHB
uniprot id: I3RYY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycoprotein hormones subunit beta family.
messages: Secreted

9925:STOML3
gene id: 9925:STOML3
uniprot id: A0A452FQB6
uniprot id: A0A452FQK3
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9925:LHX4
gene id: 9925:LHX4
uniprot id: A0A452EXX8
names: Subcellular Location Annotation
messages: Nucleus

9925:CD320
gene id: 9925:CD320
uniprot id: A0A2L1FDV6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102174032
gene id: 9925:LOC102174032
uniprot id: A0A452EEJ9
names: Similarity
messages: Belongs to the peptidase C48 family.

9925:MKNK1
gene id: 9925:MKNK1
uniprot id: A0A452G159
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:CERS2
gene id: 9925:CERS2
uniprot id: A0A452FTH2
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9925:LOC108636433
gene id: 9925:LOC108636433
uniprot id: A0A452DSQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:FAM162A
gene id: 9925:FAM162A
uniprot id: A0A452G0R2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0389 family.
messages: Membrane

9925:TERT
gene id: 9925:TERT
uniprot id: A0A452DW47
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the reverse transcriptase family. Telomerase subfamily.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.
messages: The RNA-interacting domain 1 (RD1)/N-terminal extension (NTE) is required for interaction with the pseudoknot-template domain of each of TERC dimers. It contains anchor sites that bind primer nucleotides upstream of the RNA-DNA hybrid and is thus an essential determinant of repeat addition processivity.
messages: The RNA-interacting domain 2 (RD2) is essential for both interaction with the CR4-CR5 domain of TERC and for DNA synthesis.
messages: The primer grip sequence in the RT domain is required for telomerase activity and for stable association with short telomeric primers.
messages: nucleolus
messages: nucleoplasm
messages: telomere

9925:LOC102175086
gene id: 9925:LOC102175086
uniprot id: A0A452DNL1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:NAALADL2
gene id: 9925:NAALADL2
uniprot id: A0A452F6B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Membrane

9925:NKD1
gene id: 9925:NKD1
uniprot id: A0A452FMP8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKD family.
messages: Cell autonomous antagonist of the canonical Wnt signaling pathway.
messages: Cell membrane
messages: Cytoplasm

9925:LOC102188114
gene id: 9925:LOC102188114
uniprot id: A0A452EEQ3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:MS4A1
gene id: 9925:MS4A1
uniprot id: A0A452ELI0
names: Similarity
messages: Belongs to the MS4A family.

9925:FOXL2
gene id: 9925:FOXL2
uniprot id: Q8MIP2
names: Function
names: PTM
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: Detected in the majority of somatic cells in the developing ovary.
messages: Interacts with ESR1. Interacts with UBE2I/UBC9. Interacts with SMAD3. Interacts with DDX20.
messages: Nucleus
messages: Sumoylated with SUMO1; sumoylation is required for transcriptional repression activity.
messages: Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination (By similarity). Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells (By similarity). Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Activates SIRT1 transcription under cellular stress conditions (By similarity). Activates transcription of OSR2 (By similarity). Is a transcriptional repressor of STAR (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a regulator of CYP19 expression.

9925:LOC102184282
gene id: 9925:LOC102184282
uniprot id: A0A452EX40
uniprot id: A0A452EX45
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Interacts (via extracellular domain region) with trypsin.
messages: Membrane

9925:PGM2
gene id: 9925:PGM2
uniprot id: A0A452ERF7
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9925:ITGA1
gene id: 9925:ITGA1
uniprot id: A0A452FI09
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:LOC102184937
gene id: 9925:LOC102184937
uniprot id: A0A452F873
names: Function
names: Similarity
messages: Belongs to the cytochrome c oxidase subunit 6B.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.

9925:LIX1L
gene id: 9925:LIX1L
uniprot id: A0A452EDD3
names: Similarity
messages: Belongs to the LIX1 family.

9925:LOC102184151
gene id: 9925:LOC102184151
uniprot id: A0A452DTE2
names: Similarity
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

9925:SCNM1
gene id: 9925:SCNM1
uniprot id: A0A452EL07
names: Subcellular Location Annotation
messages: Nucleus speckle
messages: nucleoplasm

9925:MSTO1
gene id: 9925:MSTO1
uniprot id: A0A452GBJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the misato family.
messages: Mitochondrion outer membrane

9925:FGF23
gene id: 9925:FGF23
uniprot id: A0A452EX52
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9925:AKAP5
gene id: 9925:AKAP5
uniprot id: A0A452E7F0
names: Subcellular Location Annotation
messages: Membrane

9925:YWHAG
gene id: 9925:YWHAG
uniprot id: A0A452G3B3
names: Similarity
messages: Belongs to the 14-3-3 family.

9925:LOC102190120
gene id: 9925:LOC102190120
uniprot id: A0A452DWW5
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PTN
gene id: 9925:PTN
uniprot id: A0A452GA51
names: Similarity
messages: Belongs to the pleiotrophin family.

9925:CARM1
gene id: 9925:CARM1
uniprot id: A0A452DXF8
names: Subcellular Location Annotation
messages: Nucleus

9925:KCNK1
gene id: 9925:KCNK1
uniprot id: A0A452G5X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Cell membrane
messages: Cytoplasmic vesicle
messages: Endosome
messages: Membrane
messages: Perikaryon
messages: Recycling endosome
messages: Synaptic cell membrane
messages: Vesicle
messages: dendrite

9925:DCLK1
gene id: 9925:DCLK1
uniprot id: A0A452FQ21
uniprot id: A0A452FQ44
names: Similarity
messages: Belongs to the protein kinase superfamily.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

9925:PTPN4
gene id: 9925:PTPN4
uniprot id: A0A452ECC7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
messages: May act at junctions between the membrane and the cytoskeleton.
messages: cytoskeleton

9925:AVIL
gene id: 9925:AVIL
uniprot id: A0A452EXK7
names: Similarity
messages: Belongs to the villin/gelsolin family.

9925:CACNB2
gene id: 9925:CACNB2
uniprot id: A0A452DN16
uniprot id: A0A452DN38
uniprot id: A0A452DN74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calcium channel beta subunit family.
messages: sarcolemma

9925:STPG1
gene id: 9925:STPG1
uniprot id: A0A452EP53
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:AVPI1
gene id: 9925:AVPI1
uniprot id: A0A452EL31
names: Function
messages: May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.

9925:LOC102188999
gene id: 9925:LOC102188999
uniprot id: A0A452F9V4
names: Function
names: Similarity
messages: Belongs to the TYW1 family.
messages: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis.

9925:SLC12A9
gene id: 9925:SLC12A9
uniprot id: A0A452GA06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9925:PDXK
gene id: 9925:PDXK
uniprot id: A0A452DXH7
names: Similarity
messages: Belongs to the pyridoxine kinase family.

9925:PTGES
gene id: 9925:PTGES
uniprot id: A0A452FZ93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Membrane

9925:BLCAP
gene id: 9925:BLCAP
uniprot id: A0A452EEN4
names: Similarity
messages: Belongs to the BLCAP family.

9925:PROS1
gene id: 9925:PROS1
uniprot id: A0A452E432
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:GRPEL2
gene id: 9925:GRPEL2
uniprot id: A0A452G916
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GrpE family.
messages: Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
messages: Mitochondrion matrix

9925:MRPL43
gene id: 9925:MRPL43
uniprot id: A0A452FTE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL43 family.
messages: Mitochondrion

9925:GALT
gene id: 9925:GALT
uniprot id: A0A452G3S3
names: Cofactor
names: Similarity
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.
messages: Binds 1 Fe cation per subunit.

9925:GTF2H4
gene id: 9925:GTF2H4
uniprot id: A0A452FP19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TFB2 family.
messages: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.
messages: Nucleus

9925:TSSC4
gene id: 9925:TSSC4
uniprot id: A0A452EA35
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TSSC4 family.
messages: Cytoplasm
messages: Nucleus

9925:MYO1C
gene id: 9925:MYO1C
uniprot id: A0A452FRT5
uniprot id: A0A452FSB2
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9925:CEBPE
gene id: 9925:CEBPE
uniprot id: A0A452FW47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. C/EBP subfamily.
messages: Nucleus

9925:ATG16L1
gene id: 9925:ATG16L1
uniprot id: A0A452G7K6
uniprot id: A0A452G7N1
uniprot id: A0A452G7W6
names: Similarity
messages: Belongs to the WD repeat ATG16 family.

9925:GABRR3
gene id: 9925:GABRR3
uniprot id: A0A452DZC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:AP2A2
gene id: 9925:AP2A2
uniprot id: A0A452G2Q0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).
messages: Belongs to the adaptor complexes large subunit family.
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.
messages: coated pit

9925:MGP
gene id: 9925:MGP
uniprot id: A0A8C2NBA2
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
messages: Belongs to the osteocalcin/matrix Gla protein family.
messages: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
messages: Requires vitamin K-dependent gamma-carboxylation for its function.
messages: Secreted

9925:GKAP1
gene id: 9925:GKAP1
uniprot id: A0A452G293
uniprot id: A0A452G2A7
names: Similarity
messages: Belongs to the GKAP1 family.

9925:NLN
gene id: 9925:NLN
uniprot id: A0A452FYX5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

9925:ACAD8
gene id: 9925:ACAD8
uniprot id: A0A452E8J9
names: Similarity
messages: Belongs to the acyl-CoA dehydrogenase family.

9925:SLC35F2
gene id: 9925:SLC35F2
uniprot id: A0A452FXY2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC35F solute transporter family.
messages: Membrane

9925:FAM207A
gene id: 9925:FAM207A
uniprot id: A0A452F171
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLX9 family.
messages: nucleolus

9925:TOR3A
gene id: 9925:TOR3A
uniprot id: A0A452FJ72
names: Similarity
messages: Belongs to the ClpA/ClpB family. Torsin subfamily.

9925:MRPS6
gene id: 9925:MRPS6
uniprot id: A0A452FE31
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.

9925:LSM2
gene id: 9925:LSM2
uniprot id: A0A8C2S2X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Binds specifically to the 3'-terminal U-tract of U6 snRNA.
messages: Nucleus

9925:RBBP5
gene id: 9925:RBBP5
uniprot id: A0A452EKQ1
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102181867
gene id: 9925:LOC102181867
uniprot id: A0A452E3N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:DOLK
gene id: 9925:DOLK
uniprot id: A0A452EI13
names: Similarity
messages: Belongs to the polyprenol kinase family.

9925:LOC102184089
gene id: 9925:LOC102184089
uniprot id: A0A452FYT6
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9925:LOC102178584
gene id: 9925:LOC102178584
uniprot id: A0A452E721
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:TNK2
gene id: 9925:TNK2
uniprot id: A0A452EC95
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Nucleus

9925:CDR2
gene id: 9925:CDR2
uniprot id: A0A452EG09
names: Similarity
messages: Belongs to the CDR2 family.

9925:LOC102169373
gene id: 9925:LOC102169373
uniprot id: A0A452FIA9
names: Similarity
messages: Belongs to the peptidase A1 family.

9925:ARPC2
gene id: 9925:ARPC2
uniprot id: A0A452DVC4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARPC2 family.
messages: Cell projection
messages: Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.
messages: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
messages: cytoskeleton
messages: synaptosome

9925:S100A5
gene id: 9925:S100A5
uniprot id: A0A452G563
names: Similarity
messages: Belongs to the S-100 family.

9925:SLC14A1
gene id: 9925:SLC14A1
uniprot id: A0A452DSC4
uniprot id: D3INW7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the urea transporter family.
messages: Cell membrane
messages: Homotrimer; each subunit contains a pore through which urea permeates (By similarity). Identified in a complex with STOM (By similarity).
messages: Mediates the transport of urea driven by a concentration gradient across the cell membranes of erythrocytes and the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism (By similarity). Facilitates water transport in erythrocytes (By similarity).
messages: Membrane

9925:AATF
gene id: 9925:AATF
uniprot id: A0A452E3Y2
names: Similarity
messages: Belongs to the AATF family.

9925:ERGIC3
gene id: 9925:ERGIC3
uniprot id: A0A452DVJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERGIC family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Golgi apparatus membrane
messages: Plays a role in transport between endoplasmic reticulum and Golgi.

9925:TBCB
gene id: 9925:TBCB
uniprot id: A0A452FXK6
names: Similarity
messages: Belongs to the TBCB family.

9925:PPP2R2B
gene id: 9925:PPP2R2B
uniprot id: A0A452ENE8
uniprot id: A0A452ENH0
names: Similarity
messages: Belongs to the phosphatase 2A regulatory subunit B family.

9925:TERF1
gene id: 9925:TERF1
uniprot id: A0A452E928
uniprot id: A0A452E9Q1
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
messages: Homodimer.
messages: Nucleus
messages: telomere

9925:SUFU
gene id: 9925:SUFU
uniprot id: A0A452FM19
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SUFU family.
messages: Cytoplasm
messages: Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).
messages: Nucleus

9925:FFAR1
gene id: 9925:FFAR1
uniprot id: A0A452E5F4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:LOC102169561
gene id: 9925:LOC102169561
uniprot id: A0A452EZS2
names: Similarity
messages: Belongs to the peptidase A1 family.

9925:RBBP8
gene id: 9925:RBBP8
uniprot id: A0A452EF39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COM1/SAE2/CtIP family.
messages: Nucleus

9925:NIFK
gene id: 9925:NIFK
uniprot id: A0A452E467
names: Subcellular Location Annotation
messages: nucleolus

9925:FMO5
gene id: 9925:FMO5
uniprot id: A0A452EK71
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters.
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Microsome membrane

9925:NCBP1
gene id: 9925:NCBP1
uniprot id: A0A452FCQ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NCBP1 family.
messages: Nucleus

9925:TRAPPC4
gene id: 9925:TRAPPC4
uniprot id: A0A452GA04
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAPP small subunits family.
messages: Endoplasmic reticulum
messages: Part of the multisubunit transport protein particle (TRAPP) complex.
messages: cis-Golgi network

9925:C28H10orf35
gene id: 9925:C28H10orf35
uniprot id: A0A452EKS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM241 family.
messages: Membrane

9925:SLC5A5
gene id: 9925:SLC5A5
uniprot id: A0A452FET9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9925:IFT57
gene id: 9925:IFT57
uniprot id: A0A452F428
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IFT57 family.
messages: cilium basal body

9925:C15H11orf88
gene id: 9925:C15H11orf88
uniprot id: A0A452GA37
names: Similarity
messages: Belongs to the HOATZ family.

9925:MMAA
gene id: 9925:MMAA
uniprot id: A0A452FMB4
names: Similarity
messages: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.

9925:SPIRE1
gene id: 9925:SPIRE1
uniprot id: A0A452E8K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spire family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytoskeleton

9925:IRF5
gene id: 9925:IRF5
uniprot id: A0A8C2PII9
names: Subcellular Location Annotation
messages: Nucleus

9925:SLC9A3R1
gene id: 9925:SLC9A3R1
uniprot id: A0A452E5R9
names: Function
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Endomembrane system
messages: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.

9925:DSCR3
gene id: 9925:DSCR3
uniprot id: A0A452FR13
names: Similarity
messages: Belongs to the VPS26 family.

9925:ZDHHC14
gene id: 9925:ZDHHC14
uniprot id: A0A452FLY2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9925:MTNR1A
gene id: 9925:MTNR1A
uniprot id: A0A452EXJ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
messages: Membrane

9925:ZPR1
gene id: 9925:ZPR1
uniprot id: A0A452EKT0
names: Similarity
messages: Belongs to the ZPR1 family.

9925:FMNL2
gene id: 9925:FMNL2
uniprot id: A0A452G9R4
uniprot id: A0A452GA58
names: Similarity
messages: Belongs to the formin homology family.

9925:DEFB123
gene id: 9925:DEFB123
uniprot id: A0A8C2NQJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the beta-defensin family.
messages: Has antibacterial activity.
messages: Secreted

9925:TEF
gene id: 9925:TEF
uniprot id: A0A452ESX6
uniprot id: A0A452EU33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. PAR subfamily.
messages: Nucleus

9925:BCL2L1
gene id: 9925:BCL2L1
uniprot id: A0A452FWV3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane
messages: Mitochondrion matrix
messages: Nucleus membrane
messages: centrosome
messages: cytosol
messages: synaptic vesicle membrane

9925:ABCC1
gene id: 9925:ABCC1
uniprot id: A0A452E542
uniprot id: A0A452E590
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
messages: Cell membrane
messages: Membrane

9925:LOC102181374
gene id: 9925:LOC102181374
uniprot id: A0A452E7P1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9925:TNR
gene id: 9925:TNR
uniprot id: A0A452DYX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

9925:OTP
gene id: 9925:OTP
uniprot id: A0A452F7B5
names: Subcellular Location Annotation
messages: Nucleus

9925:EFTUD2
gene id: 9925:EFTUD2
uniprot id: A0A452E8S4
names: Subcellular Location Annotation
messages: Nucleus

9925:NSMCE2
gene id: 9925:NSMCE2
uniprot id: A0A452GBA7
uniprot id: A0A452GBD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NSE2 family.
messages: Nucleus

9925:IHH
gene id: 9925:IHH
uniprot id: A0A452EW38
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

9925:LSM7
gene id: 9925:LSM7
uniprot id: A0A8C2SJ53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus

9925:LETM2
gene id: 9925:LETM2
uniprot id: A0A452EPM9
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion inner membrane

9925:LCA5
gene id: 9925:LCA5
uniprot id: A0A452FRP4
names: Similarity
messages: Belongs to the LCA5 family.

9925:GIP
gene id: 9925:GIP
uniprot id: A0A452E5Z8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.
messages: Secreted

9925:SUMO3
gene id: 9925:SUMO3
uniprot id: A0A452ESL6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ubiquitin family. SUMO subfamily.
messages: Nucleus

9925:ATXN2L
gene id: 9925:ATXN2L
uniprot id: A0A452E1V5
names: Similarity
messages: Belongs to the ataxin-2 family.

9925:TJP1
gene id: 9925:TJP1
uniprot id: A0A452EZ98
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: tight junction

9925:INTS9
gene id: 9925:INTS9
uniprot id: A0A452EDV6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.
messages: Nucleus

9925:ESR2
gene id: 9925:ESR2
uniprot id: B5AFX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR3 subfamily.
messages: Nucleus

9925:ADRM1
gene id: 9925:ADRM1
uniprot id: A0A452ERL1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADRM1 family.
messages: Cytoplasm
messages: Nucleus

9925:ADSL
gene id: 9925:ADSL
uniprot id: A0A452EVG3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

9925:MAN1A1
gene id: 9925:MAN1A1
uniprot id: A0A452E3Y1
names: Similarity
messages: Belongs to the glycosyl hydrolase 47 family.

9925:GNA13
gene id: 9925:GNA13
uniprot id: A0A452EJE8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-alpha family. G(12) subfamily.
messages: Membrane

9925:VPS4A
gene id: 9925:VPS4A
uniprot id: A0A452E851
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AAA ATPase family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Membrane

9925:CSF1
gene id: 9925:CSF1
uniprot id: A0A452GAN0
names: Function
names: Subunit
messages: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
messages: Homodimer or heterodimer; disulfide-linked. Interacts with CSF1R.

9925:TFEB
gene id: 9925:TFEB
uniprot id: A0A452EM33
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MiT/TFE family.
messages: Nucleus

9925:SEMA6B
gene id: 9925:SEMA6B
uniprot id: A0A452G208
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:IL12A
gene id: 9925:IL12A
uniprot id: O02814
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-6 superfamily.
messages: Heterodimer with IL12B; disulfide-linked. This heterodimer is known as interleukin IL-12. Heterodimer with EBI3/IL27B; not disulfide-linked. This heterodimer is known as interleukin IL-35. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).
messages: Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (By similarity). As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine (By similarity). Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (By similarity).
messages: Secreted

9925:UROD
gene id: 9925:UROD
uniprot id: A0A452G9G3
names: Similarity
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Homodimer.

9925:ATP5B
gene id: 9925:ATP5B
uniprot id: A0A452E573
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ATPase alpha/beta chains family.
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

9925:NDUFB8
gene id: 9925:NDUFB8
uniprot id: A0A452EKC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB8 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9925:LOC108638252
gene id: 9925:LOC108638252
uniprot id: A0A452DYD2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase g subunit family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.
messages: Mitochondrion

9925:LTBP3
gene id: 9925:LTBP3
uniprot id: A0A452FUD2
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:UTP6
gene id: 9925:UTP6
uniprot id: A0A452F303
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UTP6 family.
messages: nucleolus

9925:CRCP
gene id: 9925:CRCP
uniprot id: A0A8C2XY05
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic RPC9 RNA polymerase subunit family.
messages: Nucleus

9925:LOC108633910
gene id: 9925:LOC108633910
uniprot id: A0A452DS03
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9925:MYO1F
gene id: 9925:MYO1F
uniprot id: A0A452EPM6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9925:CDH19
gene id: 9925:CDH19
uniprot id: A0A452E1Y4
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9925:LOC102191173
gene id: 9925:LOC102191173
uniprot id: A0A452GAI5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.
messages: Golgi apparatus

9925:ACTR1B
gene id: 9925:ACTR1B
uniprot id: A0A452FL06
names: Similarity
messages: Belongs to the actin family.

9925:SNW1
gene id: 9925:SNW1
uniprot id: A0A452E277
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SNW family.
messages: Identified in the spliceosome C complex.
messages: Involved in pre-mRNA splicing.
messages: Nucleus

9925:LOC102178967
gene id: 9925:LOC102178967
uniprot id: A0A8C2R7P9
names: Similarity
messages: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.

9925:CCHCR1
gene id: 9925:CCHCR1
uniprot id: A0A452FBK3
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a regulator of keratinocyte proliferation or differentiation.
messages: Nucleus

9925:AFF1
gene id: 9925:AFF1
uniprot id: A0A452DWP5
uniprot id: A0A452DX33
names: Similarity
messages: Belongs to the AF4 family.

9925:CILP2
gene id: 9925:CILP2
uniprot id: A0A452EW91
names: Subcellular Location Annotation
messages: extracellular matrix

9925:LOC102179187
gene id: 9925:LOC102179187
uniprot id: A0A452DXC5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:RRS1
gene id: 9925:RRS1
uniprot id: A0A452DZB0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRS1 family.
messages: Involved in ribosomal large subunit assembly.
messages: Nucleus

9925:SMG9
gene id: 9925:SMG9
uniprot id: A0A452FM24
names: Similarity
messages: Belongs to the SMG9 family.

9925:NR1D1
gene id: 9925:NR1D1
uniprot id: A0A452F0F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9925:COQ10B
gene id: 9925:COQ10B
uniprot id: A0A452FG73
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9925:HNF4A
gene id: 9925:HNF4A
uniprot id: A0A452EZL4
uniprot id: A0A452EZQ3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9925:SLC35D1
gene id: 9925:SLC35D1
uniprot id: A0A452G7Q2
names: Subcellular Location Annotation
messages: Membrane

9925:UPP2
gene id: 9925:UPP2
uniprot id: A0A452F2A2
names: Function
names: Similarity
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

9925:PEX13
gene id: 9925:PEX13
uniprot id: A0A452EGG1
names: Similarity
messages: Belongs to the peroxin-13 family.

9925:MYO9B
gene id: 9925:MYO9B
uniprot id: A0A452E9N9
uniprot id: A0A452E9P1
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9925:NDUFS2
gene id: 9925:NDUFS2
uniprot id: A0A452FXF1
names: Similarity
messages: Belongs to the complex I 49 kDa subunit family.

9925:FAM72A
gene id: 9925:FAM72A
uniprot id: A0A452FK62
names: Similarity
messages: Belongs to the FAM72 family.

9925:RSBN1
gene id: 9925:RSBN1
uniprot id: A0A8C2RC24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the round spermatid basic protein 1 family.
messages: Nucleus

9925:LOC102172435
gene id: 9925:LOC102172435
uniprot id: A0A452E3R2
names: Function
names: Similarity
messages: Belongs to the ferritin family.
messages: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

9925:LOC102177219
gene id: 9925:LOC102177219
uniprot id: A0A452DVG9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:GPR182
gene id: 9925:GPR182
uniprot id: A0A452DW22
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:DDA1
gene id: 9925:DDA1
uniprot id: A0A8C2NZX9
names: Similarity
messages: Belongs to the DDA1 family.

9925:FAM221A
gene id: 9925:FAM221A
uniprot id: A0A452E3K9
uniprot id: A0A452E3N6
names: Similarity
messages: Belongs to the FAM221 family.

9925:B4GALNT2
gene id: 9925:B4GALNT2
uniprot id: A0A0K0PU76
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family.
messages: Membrane

9925:GALM
gene id: 9925:GALM
uniprot id: A0A452EPB0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aldose epimerase family.
messages: Monomer.
messages: Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism.

9925:COPS9
gene id: 9925:COPS9
uniprot id: A0A452DW83
names: Similarity
messages: Belongs to the CSN9 family.

9925:GFAP
gene id: 9925:GFAP
uniprot id: A0A452FV03
names: Similarity
messages: Belongs to the intermediate filament family.

9925:SNRNP200
gene id: 9925:SNRNP200
uniprot id: A0A452FF99
names: Similarity
messages: Belongs to the helicase family. SKI2 subfamily.

9925:BORA
gene id: 9925:BORA
uniprot id: A0A452DUX0
names: Similarity
messages: Belongs to the BORA family.

9925:IL1B
gene id: 9925:IL1B
uniprot id: A7Y3X8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-1 family.
messages: IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.
messages: Lysosome
messages: Monomer. Interacts with MEFV.
messages: Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.
messages: Secreted
messages: cytosol
messages: extracellular exosome

9925:LPXN
gene id: 9925:LPXN
uniprot id: A0A452FAM8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paxillin family.
messages: Cell membrane
messages: Cytoplasm
messages: Nucleus
messages: The LIM domain 3 is critical for focal adhesion targeting and the suppression of paxillin (PXN) tyrosine phosphorylation. The LIM domain 3 alone or both LIM domains 3 and 4 can mediate interaction with AR.
messages: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN).
messages: focal adhesion
messages: perinuclear region
messages: podosome

9925:TACC1
gene id: 9925:TACC1
uniprot id: A0A452FYM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACC family.
messages: Cytoplasm

9925:TTR
gene id: 9925:TTR
uniprot id: A0A452E2C8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transthyretin family.
messages: Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4.
messages: Secreted
messages: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

9925:C9H6orf120
gene id: 9925:C9H6orf120
uniprot id: A0A452DRG3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0669 family.
messages: May be involved in induction of apoptosis in CD4(+) T-cells, but not CD8(+) T-cells or hepatocytes.
messages: Secreted

9925:HTR1D
gene id: 9925:HTR1D
uniprot id: A0A452E6Y0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Homodimer. Heterodimer with HTR1B.
messages: Membrane

9925:FAR1
gene id: 9925:FAR1
uniprot id: A0A452F3J7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fatty acyl-CoA reductase family.
messages: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
messages: Peroxisome membrane

9925:BARX2
gene id: 9925:BARX2
uniprot id: A0A452FKT6
names: Subcellular Location Annotation
messages: Nucleus

9925:CSRNP1
gene id: 9925:CSRNP1
uniprot id: A0A452FLI0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AXUD1 family.
messages: Nucleus

9925:BMP8B
gene id: 9925:BMP8B
uniprot id: A0A452G135
names: Similarity
messages: Belongs to the TGF-beta family.

9925:NDUFAF2
gene id: 9925:NDUFAF2
uniprot id: A0A452GBD1
names: Similarity
messages: Belongs to the complex I NDUFA12 subunit family.

9925:LPO
gene id: 9925:LPO
uniprot id: A0A452E9Y6
names: Activity Regulation
names: Biotechnology
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Tissue Specificity
messages: Belongs to the peroxidase family. XPO subfamily.
messages: Binds 1 Ca(2+) ion per heterodimer.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per heterodimer.
messages: Cytoplasm
messages: Heme-containing oxidoreductase which catalyzes the conversion of thiocyanate (SCN(-)) into antimicrobial agent hypothiocyanous acid (OSCN(-)) in the presence of hydrogen peroxide (H2O2) (By similarity). Also involved in the conversion of iodide (I(-)) into hypoiodite (IO(-)) in the presence of H2O2 (By similarity). Responsible for the inactivation of a wide range of micro-organisms and hence, important component of defense mechanism (PubMed:10894086). Shows antibacterial properties against several Gram-positive bacteria including some Staphylococcus species and Gram-negative bacteria including E.coli, P.aeruginosa and some Salmonella species (PubMed:10894086). Inhibits the growth of several fungi including A.niger, Trichoderma species, C.cassicola, P.meadii and C.salmonicolor (PubMed:10894086). Does not have anti-fungal activity towards C.albicans and Pythium species (PubMed:10894086). May protect the udder from infection and may promote growth in newborns (PubMed:10894086). May be implicated in airway host defense against infection (By similarity). May contribute to maintaining an appropriate H2O2 cellular level, therefore protecting cells from H2O2-caused injuries and inflammation (By similarity).
messages: Inhibited by small molecule methimazole (MMZ).
messages: Mammary gland; milk.
messages: Secreted
messages: The drug propylthiouracilin was reported to bind to the distal heme-pockets of LPO (PubMed:25760705). However, the paper was retracted as some concerns were raised about the modeling.
messages: The lactoperoxidase system is used by the dairy industry for the preservation of raw milk during transportation (PubMed:10894086). Freshly obtained milk is supplemented with thiocyanate and hydrogen peroxide which are used by milk LPO to produce antimicrobial agents (PubMed:10894086).
messages: Thiocyanate (SCN(-)) and hypothiocyanite (OSCN(-)) are bound in the distal heme cavity. The iodide ion (I(-)) occupies a position which is stabilized by the interactions with heme moiety, His-226, Arg-372 and Glu-375. Hydrogen peroxide is held between the heme iron and His-226.

9925:DPM2
gene id: 9925:DPM2
uniprot id: A0A8C2RGM7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DPM2 family.
messages: Component of the dolichol-phosphate mannose (DPM) synthase complex.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.

9925:NRF1
gene id: 9925:NRF1
uniprot id: A0A452E8Z6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NRF1/Ewg family.
messages: Nucleus

9925:FAM228A
gene id: 9925:FAM228A
uniprot id: A0A8C2SBQ2
names: Similarity
messages: Belongs to the FAM228 family.

9925:TRIP13
gene id: 9925:TRIP13
uniprot id: A0A452FN60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AAA ATPase family. PCH2 subfamily.
messages: Nucleus
messages: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways.
messages: Specifically interacts with the ligand binding domain of the thyroid receptor (TR). This interaction does not require the presence of thyroid hormone for its interaction. Interacts with proteasome subunit PSMA8; to participate in meiosis progression during spermatogenesis.

9925:SLC35E4
gene id: 9925:SLC35E4
uniprot id: A0A452FC11
names: Subcellular Location Annotation
messages: Membrane

9925:POU3F1
gene id: 9925:POU3F1
uniprot id: A0A452DUK6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family. Class-3 subfamily.
messages: Nucleus

9925:SLC34A1
gene id: 9925:SLC34A1
uniprot id: A0A452F936
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the SLC34A transporter family.
messages: Cell membrane
messages: Membrane

9925:SERPING1
gene id: 9925:SERPING1
uniprot id: A0A452F9H1
names: Similarity
messages: Belongs to the serpin family.

9925:TMEM147
gene id: 9925:TMEM147
uniprot id: I6VSD2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
names: Tissue Specificity
messages: (Microbial infection) Interacts with H.contortus GAL-1 (via domain galectin 2).
messages: (Microbial infection) Involved in the immunomodulatory effects exerted by H.contortus GAL-1 on host peripheral blood mononuclear cells to down-regulate host immune response.
messages: Belongs to the TMEM147 family.
messages: Cell membrane
messages: Component of the back of Sec61 (BOS) complex, composed of NCLN/Nicalin, NOMO (NOMO1, NOMO2 or NOMO3) and TMEM147. The BOS complex is part of the multi-pass translocon (MPT) complex, composed of three subcomplexes, the GEL complex (composed of RAB5IF/OPTI and TMCO1), the BOS complex (composed of NCLN/Nicalin, NOMO and TMEM147) and the PAT complex (composed of WDR83OS/Asterix and CCDC47). The MPT complex associates with the SEC61 complex. Interacts with CHRM3, CHRM1 and AVPR2. Interacts with LBR; promoting LBR localization to the nucleus inner membrane. Interacts with DHCR7.
messages: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. Regulates LBR localization to the nucleus inner membrane.
messages: Endoplasmic reticulum membrane
messages: Expressed in T-cells, B-cells and monocytes.
messages: Nucleus membrane

9925:PARD6B
gene id: 9925:PARD6B
uniprot id: A0A452FZS3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PAR6 family.
messages: Cytoplasm
messages: tight junction

9925:CA7
gene id: 9925:CA7
uniprot id: A0A452FJF3
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

9925:TMEM214
gene id: 9925:TMEM214
uniprot id: A0A452DVD7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TMEM214 family.
messages: Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.
messages: Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:SIGMAR1
gene id: 9925:SIGMAR1
uniprot id: A0A452G380
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ERG2 family.
messages: Cell junction
messages: Cytoplasmic vesicle
messages: Endoplasmic reticulum membrane
messages: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.
messages: Homotrimer.
messages: Lipid droplet
messages: Membrane
messages: Nucleus envelope
messages: Nucleus inner membrane
messages: Nucleus outer membrane
messages: Postsynaptic density membrane
messages: The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.
messages: Vesicle
messages: growth cone

9925:NGFR
gene id: 9925:NGFR
uniprot id: A0A452F7J6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:COPA
gene id: 9925:COPA
uniprot id: A0A452EPZ3
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: COPI-coated vesicle membrane
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane
messages: Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.
messages: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.

9925:SLC22A4
gene id: 9925:SLC22A4
uniprot id: A0A452FJ23
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Basal cell membrane
messages: Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
messages: Interacts with PDZK1.

9925:DENR
gene id: 9925:DENR
uniprot id: A0A452G331
names: Similarity
messages: Belongs to the DENR family.

9925:C14H8orf22
gene id: 9925:C14H8orf22
uniprot id: A0A452F0I0
names: Similarity
messages: Belongs to the PPDPF family.

9925:SCNN1A
gene id: 9925:SCNN1A
uniprot id: A0A452DZR4
names: Subcellular Location Annotation
messages: Membrane

9925:RBPJ
gene id: 9925:RBPJ
uniprot id: A0A452FLF2
uniprot id: A0A452FLR6
uniprot id: A0A452FMH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Su(H) family.
messages: Nucleus

9925:LZTFL1
gene id: 9925:LZTFL1
uniprot id: A0A452FVB8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the LZTFL1 family.
messages: Cytoplasm
messages: Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
messages: Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking.

9925:LOC102175006
gene id: 9925:LOC102175006
uniprot id: A0A452DRX2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102181565
gene id: 9925:LOC102181565
uniprot id: A0A452DVQ3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS1 family.
messages: Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.
messages: Cytoplasm
messages: May play a role during erythropoiesis through regulation of transcription factor DDIT3.
messages: Nucleus
messages: nucleolus

9925:IL17RD
gene id: 9925:IL17RD
uniprot id: A0A452G5U7
names: Subcellular Location Annotation
messages: Membrane

9925:SLC6A9
gene id: 9925:SLC6A9
uniprot id: A0A452G8T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.
messages: Cell membrane
messages: Membrane

9925:SARM1
gene id: 9925:SARM1
uniprot id: A0A452DP93
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SARM1 family.
messages: axon

9925:SMC4
gene id: 9925:SMC4
uniprot id: A0A452F7D5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMC family.
messages: Chromosome
messages: Nucleus

9925:LOC102187069
gene id: 9925:LOC102187069
uniprot id: A0A452EMI5
names: Similarity
messages: Belongs to the COX20 family.

9925:ING3
gene id: 9925:ING3
uniprot id: A0A452E0X8
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ING family.
messages: Component of an histone acetyltransferase complex.
messages: Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.
messages: Nucleus
messages: The PHD-type zinc finger mediates the binding to H3K4me3.

9925:CBFB
gene id: 9925:CBFB
uniprot id: A0A452FEY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CBF-beta family.
messages: Nucleus

9925:IL18R1
gene id: 9925:IL18R1
uniprot id: A0A452E1R2
names: Similarity
messages: Belongs to the interleukin-1 receptor family.

9925:CDC26
gene id: 9925:CDC26
uniprot id: A0A452EFE9
names: Function
names: Similarity
messages: Belongs to the CDC26 family.
messages: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

9925:DDIT4
gene id: 9925:DDIT4
uniprot id: A0A452E9D5
names: Similarity
messages: Belongs to the DDIT4 family.

9925:PGLYRP3
gene id: 9925:PGLYRP3
uniprot id: A0A8C2R311
uniprot id: A0A8C2R317
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

9925:NUS1
gene id: 9925:NUS1
uniprot id: A0A452G2N7
names: Similarity
messages: Belongs to the UPP synthase family.

9925:ARL4D
gene id: 9925:ARL4D
uniprot id: A0A452DRY5
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9925:CPS1
gene id: 9925:CPS1
uniprot id: A0A452G0C9
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:TNFSF13B
gene id: 9925:TNFSF13B
uniprot id: C4NZX0
names: Similarity
messages: Belongs to the tumor necrosis factor family.

9925:STAMBPL1
gene id: 9925:STAMBPL1
uniprot id: A0A452E7N6
names: Similarity
messages: Belongs to the peptidase M67C family.

9925:LOC102173704
gene id: 9925:LOC102173704
uniprot id: A0A452DXV6
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:MTAP
gene id: 9925:MTAP
uniprot id: A0A452EN12
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
messages: Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
messages: Cytoplasm
messages: Homotrimer.
messages: Nucleus

9925:NCAPH
gene id: 9925:NCAPH
uniprot id: A0A452FTW5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CND2 (condensin subunit 2) family.
messages: Chromosome
messages: Cytoplasm
messages: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.

9925:LOC102169002
gene id: 9925:LOC102169002
uniprot id: A0A452EEV6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9925:DSG4
gene id: 9925:DSG4
uniprot id: A0A097ITJ2
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9925:VPS25
gene id: 9925:VPS25
uniprot id: A0A452ES90
names: Similarity
messages: Belongs to the VPS25 family.

9925:GUCA2A
gene id: 9925:GUCA2A
uniprot id: A0A452DRJ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9925:ZRANB2
gene id: 9925:ZRANB2
uniprot id: A0A452E095
uniprot id: A0A452E0B3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZRANB2 family.
messages: Nucleus
messages: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.

9925:MMRN1
gene id: 9925:MMRN1
uniprot id: A0A452FPQ0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:SLC1A1
gene id: 9925:SLC1A1
uniprot id: A0A452F4Y8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9925:RIPK2
gene id: 9925:RIPK2
uniprot id: A0A452F5Y4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
messages: Cytoplasm
messages: Found in a signaling complex consisting of at least ARHGEF2, NOD2 and RIPK2.
messages: Serine/threonine/tyrosine-protein kinase that plays an essential role in modulation of innate and adaptive immune responses. Acts as a key effector of NOD1 and NOD2 signaling pathways: upon activation by bacterial peptidoglycans, NOD1 and NOD2 oligomerize and recruit RIPK2 via CARD-CARD domains, leading to the formation of RIPK2 filaments.

9925:MED6
gene id: 9925:MED6
uniprot id: A0A452FWS0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 6 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex.
messages: Nucleus

9925:TNS1
gene id: 9925:TNS1
uniprot id: A0A452ELZ4
uniprot id: A0A452EMM8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PTEN phosphatase protein family.
messages: focal adhesion

9925:PPIB
gene id: 9925:PPIB
uniprot id: A0A452F9Y8
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9925:TIMP2
gene id: 9925:TIMP2
uniprot id: A0A452G0J3
names: Similarity
messages: Belongs to the protease inhibitor I35 (TIMP) family.

9925:METTL14
gene id: 9925:METTL14
uniprot id: A0A452FYV2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MT-A70-like family.
messages: Heterodimer; heterodimerizes with METTL3 to form an antiparallel heterodimer that constitutes an active methyltransferase.
messages: Nucleus
messages: The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation. In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization. M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis. M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells.

9925:NME9
gene id: 9925:NME9
uniprot id: A0A452EKJ7
names: Similarity
messages: Belongs to the NDK family.

9925:CENPN
gene id: 9925:CENPN
uniprot id: A0A452EEF2
names: Similarity
messages: Belongs to the CENP-N/CHL4 family.

9925:LOC102177974
gene id: 9925:LOC102177974
uniprot id: A0A452ECV0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:UBA2
gene id: 9925:UBA2
uniprot id: A0A452EJL0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ubiquitin-activating E1 family.
messages: Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.
messages: Nucleus
messages: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

9925:LOC102181615
gene id: 9925:LOC102181615
uniprot id: A0A452DNV0
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SYNGR4
gene id: 9925:SYNGR4
uniprot id: A0A452G6V7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9925:PAM16
gene id: 9925:PAM16
uniprot id: A0A8C2RFD7
names: Similarity
messages: Belongs to the TIM16/PAM16 family.

9925:EME1
gene id: 9925:EME1
uniprot id: A0A452EUD1
names: Similarity
messages: Belongs to the EME1/MMS4 family.

9925:CFAP45
gene id: 9925:CFAP45
uniprot id: A0A452EXX0
names: Similarity
messages: Belongs to the CFAP45 family.

9925:NXT1
gene id: 9925:NXT1
uniprot id: A0A8C2R5K4
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.
messages: Nucleus

9925:CACNA2D1
gene id: 9925:CACNA2D1
uniprot id: A0A452FSR3
uniprot id: A0A452FSU2
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9925:ANPEP
gene id: 9925:ANPEP
uniprot id: A0A452E2A2
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Membrane

9925:IQSEC1
gene id: 9925:IQSEC1
uniprot id: A0A452G0T9
uniprot id: A0A452G0X9
names: Similarity
messages: Belongs to the BRAG family.

9925:AZIN2
gene id: 9925:AZIN2
uniprot id: A0A8C2N7F9
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9925:LOC102171142
gene id: 9925:LOC102171142
uniprot id: A0A452EK55
names: Similarity
messages: Belongs to the serpin family.

9925:CEBPG
gene id: 9925:CEBPG
uniprot id: A0A452DXM1
names: Similarity
messages: Belongs to the bZIP family. C/EBP subfamily.

9925:LOC102176522
gene id: 9925:LOC102176522
uniprot id: A0A452FQ73
names: Similarity
messages: Belongs to the intermediate filament family.

9925:THYN1
gene id: 9925:THYN1
uniprot id: A0A452ENW2
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.

9925:ITGA7
gene id: 9925:ITGA7
uniprot id: A0A452FU63
uniprot id: A0A452FU83
uniprot id: A0A452FUV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9925:PIGZ
gene id: 9925:PIGZ
uniprot id: A0A452FD47
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 22 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:CDC37
gene id: 9925:CDC37
uniprot id: A0A452DMC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9925:CHST9
gene id: 9925:CHST9
uniprot id: A0A452FKC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:ADGRF5
gene id: 9925:ADGRF5
uniprot id: A0A452DXP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

9925:LOC102187504
gene id: 9925:LOC102187504
uniprot id: A0A452FGU1
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9925:FANCM
gene id: 9925:FANCM
uniprot id: A0A452EPF1
names: Similarity
messages: Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.

9925:PSD4
gene id: 9925:PSD4
uniprot id: A0A452G149
names: Subcellular Location Annotation
messages: Membrane
messages: ruffle membrane

9925:HYLS1
gene id: 9925:HYLS1
uniprot id: A0A452G0X6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HYLS1 family.
messages: centriole
messages: cilium

9925:ATP10D
gene id: 9925:ATP10D
uniprot id: A0A452EZV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
messages: Membrane

9925:LOC102188265
gene id: 9925:LOC102188265
uniprot id: A0A452DL87
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9925:CNOT8
gene id: 9925:CNOT8
uniprot id: A0A452ETP2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAF1 family.
messages: Nucleus

9925:SENP6
gene id: 9925:SENP6
uniprot id: A0A452DZQ4
names: Similarity
messages: Belongs to the peptidase C48 family.

9925:IL7R
gene id: 9925:IL7R
uniprot id: A0A452FG19
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the type I cytokine receptor family. Type 4 subfamily.
messages: Membrane
messages: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
messages: The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R.

9925:NAALAD2
gene id: 9925:NAALAD2
uniprot id: A0A452EZS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Membrane

9925:PCSK4
gene id: 9925:PCSK4
uniprot id: A0A452F304
names: Similarity
messages: Belongs to the peptidase S8 family.

9925:PPT2
gene id: 9925:PPT2
uniprot id: A0A452EW18
uniprot id: A0A452EW43
names: Similarity
messages: Belongs to the palmitoyl-protein thioesterase family.

9925:FAM83D
gene id: 9925:FAM83D
uniprot id: A0A452FTM2
names: Similarity
messages: Belongs to the FAM83 family.

9925:SHMT2
gene id: 9925:SHMT2
uniprot id: A0A452DPN1
names: Function
names: Similarity
messages: Belongs to the SHMT family.
messages: Interconversion of serine and glycine.

9925:CHN1
gene id: 9925:CHN1
uniprot id: A0A452F0M4
names: Function
messages: GTPase-activating protein for p21-rac.

9925:BAX
gene id: 9925:BAX
uniprot id: A0A076FVB8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Bcl-2 family.
messages: Membrane

9925:CDIPT
gene id: 9925:CDIPT
uniprot id: A0A452F8S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

9925:EPHA7
gene id: 9925:EPHA7
uniprot id: A0A452FFD4
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102180236
gene id: 9925:LOC102180236
uniprot id: A0A452FWD5
names: Similarity
messages: Belongs to the KHDC1 family.

9925:PA2G4
gene id: 9925:PA2G4
uniprot id: A0A452DZ57
names: Similarity
messages: Belongs to the peptidase M24 family.

9925:AGK
gene id: 9925:AGK
uniprot id: A0A452FRX8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AGK family.
messages: Membrane
messages: Mitochondrion inner membrane
messages: Mitochondrion intermembrane space

9925:ZCCHC6
gene id: 9925:ZCCHC6
uniprot id: A0A452F1B1
uniprot id: A0A452F1I9
uniprot id: A0A452F1S2
uniprot id: A0A452F1Y5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B-like family.
messages: Cytoplasm

9925:B9D2
gene id: 9925:B9D2
uniprot id: A0A452FVZ5
names: Subcellular Location Annotation
messages: cilium basal body

9925:PTCH1
gene id: 9925:PTCH1
uniprot id: A0A452EJ12
uniprot id: A0A452EJ24
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9925:VPS33B
gene id: 9925:VPS33B
uniprot id: A0A452EH53
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STXBP/unc-18/SEC1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: clathrin-coated vesicle

9925:TPST1
gene id: 9925:TPST1
uniprot id: A0A452FDP9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein sulfotransferase family.
messages: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
messages: Golgi apparatus membrane

9925:SERPINA12
gene id: 9925:SERPINA12
uniprot id: A0A452ETR7
uniprot id: A0A452EU68
names: Similarity
messages: Belongs to the serpin family.

9925:KCNJ12
gene id: 9925:KCNJ12
uniprot id: A0A452E375
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.
messages: Cell membrane
messages: Membrane

9925:FXR2
gene id: 9925:FXR2
uniprot id: A0A452DQC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMR1 family.
messages: Cytoplasmic ribonucleoprotein granule
messages: Postsynapse
messages: Synapse

9925:ARHGDIB
gene id: 9925:ARHGDIB
uniprot id: A0A452E8X3
names: Similarity
messages: Belongs to the Rho GDI family.

9925:SNTG1
gene id: 9925:SNTG1
uniprot id: A0A452FSQ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the syntrophin family.
messages: cytoskeleton

9925:LOC108637981
gene id: 9925:LOC108637981
uniprot id: A0A452DZV6
names: Subcellular Location Annotation
messages: Secreted

9925:MUS81
gene id: 9925:MUS81
uniprot id: A0A452FVR9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XPF family.
messages: Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).
messages: Interacts with EME1.
messages: Nucleus

9925:MAML1
gene id: 9925:MAML1
uniprot id: A0A452FZ77
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mastermind family.
messages: Nucleus speckle

9925:EBF3
gene id: 9925:EBF3
uniprot id: A0A452F963
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the COE family.
messages: Nucleus

9925:LIG4
gene id: 9925:LIG4
uniprot id: A0A452DM92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP-dependent DNA ligase family.
messages: Nucleus

9925:ZFHX4
gene id: 9925:ZFHX4
uniprot id: A0A452EYP1
names: Subcellular Location Annotation
messages: Nucleus

9925:WNT3A
gene id: 9925:WNT3A
uniprot id: A0A452EUC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Wnt family.
messages: Ligand for members of the frizzled family of seven transmembrane receptors.
messages: extracellular matrix

9925:MTNR1B
gene id: 9925:MTNR1B
uniprot id: A0A452FBZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:ANKS3
gene id: 9925:ANKS3
uniprot id: A0A452EY94
names: Function
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9925:BAC5
gene id: 9925:BAC5
uniprot id: P82018
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: BAC5 sequence consists almost exclusively of X-P-P-Y repeats.
messages: Belongs to the cathelicidin family.
messages: Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Shows a potent antimicrobial activity against the Gram-negative bacteria E.coli, S.typhimurium and P.aeruginosa. Less active against the Gram-positive bacteria S.aureus, L.monocytogenes and B.subtilis.
messages: Elastase is responsible for its maturation.
messages: Secreted

9925:GABARAP
gene id: 9925:GABARAP
uniprot id: A0A452FI93
names: Similarity
messages: Belongs to the ATG8 family.

9925:SEC61G
gene id: 9925:SEC61G
uniprot id: A0A8C2PBE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecE/SEC61-gamma family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:LOC102172464
gene id: 9925:LOC102172464
uniprot id: A0A452DPC5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:EYA3
gene id: 9925:EYA3
uniprot id: A0A452G7T6
uniprot id: A0A452G803
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9925:ATG13
gene id: 9925:ATG13
uniprot id: A0A452ELX3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.
messages: Belongs to the ATG13 family. Metazoan subfamily.
messages: Preautophagosomal structure

9925:CHRM1
gene id: 9925:CHRM1
uniprot id: A0A452ECH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane
messages: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

9925:UXS1
gene id: 9925:UXS1
uniprot id: A0A452FSN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.
messages: Golgi stack membrane
messages: Membrane

9925:PLG
gene id: 9925:PLG
uniprot id: A0A8C2R2U7
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family. Plasminogen subfamily.
messages: Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
messages: Secreted

9925:TXNDC8
gene id: 9925:TXNDC8
uniprot id: A0A452G697
names: Similarity
messages: Belongs to the thioredoxin family.

9925:MTMR6
gene id: 9925:MTMR6
uniprot id: A0A452FVA9
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

9925:SLC6A3
gene id: 9925:SLC6A3
uniprot id: A0A452FJC8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.
messages: Cell membrane
messages: Membrane
messages: axon
messages: neuron projection

9925:RAD51D
gene id: 9925:RAD51D
uniprot id: A0A452FA90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family. RAD51 subfamily.
messages: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.
messages: Nucleus

9925:MRPS33
gene id: 9925:MRPS33
uniprot id: A0A452FUE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS33 family.
messages: Mitochondrion

9925:ASF1B
gene id: 9925:ASF1B
uniprot id: A0A452EXZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ASF1 family.
messages: Nucleus

9925:GMPPB
gene id: 9925:GMPPB
uniprot id: A0A452DLU2
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9925:GPR61
gene id: 9925:GPR61
uniprot id: A0A452DM10
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:ITPKB
gene id: 9925:ITPKB
uniprot id: A0A452EV15
names: Similarity
messages: Belongs to the inositol phosphokinase (IPK) family.

9925:APCS
gene id: 9925:APCS
uniprot id: A0A452G8G4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pentraxin family.
messages: Binds 2 calcium ions per subunit.
messages: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
messages: Secreted

9925:NEIL1
gene id: 9925:NEIL1
uniprot id: A0A452FPL4
names: Similarity
messages: Belongs to the FPG family.

9925:CTNNBL1
gene id: 9925:CTNNBL1
uniprot id: A0A452FPI8
names: Subcellular Location Annotation
messages: Nucleus

9925:SIKE1
gene id: 9925:SIKE1
uniprot id: A0A452ELT8
names: Similarity
messages: Belongs to the SIKE family.

9925:POLG2
gene id: 9925:POLG2
uniprot id: A0A452F0G0
uniprot id: A0A8C2S6A0
names: Subcellular Location Annotation
messages: Mitochondrion

9925:RRP1B
gene id: 9925:RRP1B
uniprot id: A0A452FJI3
uniprot id: A0A8C2NLT6
names: Similarity
messages: Belongs to the RRP1 family.

9925:PANK4
gene id: 9925:PANK4
uniprot id: A0A452F5Y5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Activity is strongly promoted by Co(2+), Ni(2+), Mg(2+) and Mn(2+). Activity is inhibited by EDTA.
messages: Belongs to the type II pantothenate kinase family.
messages: Cytoplasm
messages: Homodimer. Interacts with PKM.
messages: In the N-terminal section; belongs to the type II pantothenate kinase family.
messages: Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels.

9925:TOR1AIP1
gene id: 9925:TOR1AIP1
uniprot id: A0A452G682
uniprot id: A0A452G6H2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TOR1AIP family.
messages: Membrane

9925:PLD3
gene id: 9925:PLD3
uniprot id: A0A452FWZ1
names: Similarity
messages: Belongs to the phospholipase D family.

9925:KIAA1161
gene id: 9925:KIAA1161
uniprot id: A0A452E235
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9925:TRMO
gene id: 9925:TRMO
uniprot id: A0A452E237
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

9925:BACE2
gene id: 9925:BACE2
uniprot id: A0A452FB32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A1 family.
messages: Endosome
messages: Membrane

9925:ODC1
gene id: 9925:ODC1
uniprot id: A0A452GA10
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family.

9925:NAA35
gene id: 9925:NAA35
uniprot id: A0A452EJC1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells.
messages: Belongs to the MAK10 family.
messages: Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.
messages: Cytoplasm

9925:OGDHL
gene id: 9925:OGDHL
uniprot id: A0A452FP45
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9925:NEIL3
gene id: 9925:NEIL3
uniprot id: A0A452DZ16
names: Similarity
messages: Belongs to the FPG family.

9925:KYNU
gene id: 9925:KYNU
uniprot id: A0A452G451
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kynureninase family.
messages: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:NDUFB4
gene id: 9925:NDUFB4
uniprot id: A0A452EJU6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB4 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9925:OLFM2
gene id: 9925:OLFM2
uniprot id: A0A452FA39
uniprot id: A0A452FA44
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9925:HSD17B4
gene id: 9925:HSD17B4
uniprot id: A0A452EBH2
names: Subcellular Location Annotation
messages: Peroxisome

9925:EPHA5
gene id: 9925:EPHA5
uniprot id: A0A452E3I8
uniprot id: A0A452E3J6
uniprot id: A0A452E3M1
names: Subcellular Location Annotation
messages: Membrane

9925:PTH1R
gene id: 9925:PTH1R
uniprot id: A0A452DV82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family.
messages: Cell membrane
messages: Membrane

9925:POPDC2
gene id: 9925:POPDC2
uniprot id: A0A452ENH5
names: Similarity
messages: Belongs to the popeye family.

9925:DDAH2
gene id: 9925:DDAH2
uniprot id: A0A452G8U8
names: Function
names: Similarity
messages: Belongs to the DDAH family.
messages: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

9925:HSPA4
gene id: 9925:HSPA4
uniprot id: A0A452DZT8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 70 family.
messages: Cytoplasm
messages: Interacts with TJP1/ZO-1.

9925:AXIN2
gene id: 9925:AXIN2
uniprot id: A0A452FEH8
names: Subcellular Location Annotation
messages: Cytoplasm

9925:CCNJL
gene id: 9925:CCNJL
uniprot id: A0A452F9B6
names: Similarity
messages: Belongs to the cyclin family.

9925:OPALIN
gene id: 9925:OPALIN
uniprot id: A0A452EYA0
uniprot id: A0A8C2RNL9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.
messages: Membrane

9925:STEAP3
gene id: 9925:STEAP3
uniprot id: A0A452FDC7
uniprot id: A0A452FDS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9925:MPHOSPH10
gene id: 9925:MPHOSPH10
uniprot id: A0A452FUW2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPP10 family.
messages: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
messages: nucleolus

9925:EBNA1BP2
gene id: 9925:EBNA1BP2
uniprot id: A0A452FMC8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP2 family.
messages: Required for the processing of the 27S pre-rRNA.
messages: nucleolus

9925:CDH15
gene id: 9925:CDH15
uniprot id: A0A452F7W3
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9925:KAT6B
gene id: 9925:KAT6B
uniprot id: A0A452DJS0
names: Similarity
messages: Belongs to the MYST (SAS/MOZ) family.

9925:HAAO
gene id: 9925:HAAO
uniprot id: A0A452EKB2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the 3-HAO family.
messages: Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

9925:HRH3
gene id: 9925:HRH3
uniprot id: A0A452DTH6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:SLC5A9
gene id: 9925:SLC5A9
uniprot id: A0A452DWV2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Cell membrane
messages: Membrane

9925:ISYNA1
gene id: 9925:ISYNA1
uniprot id: A0A452FRH9
names: Similarity
messages: Belongs to the myo-inositol 1-phosphate synthase family.

9925:RNGTT
gene id: 9925:RNGTT
uniprot id: A0A452F5W0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.
messages: In the C-terminal section; belongs to the eukaryotic GTase family.
messages: In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.
messages: Nucleus

9925:CHST1
gene id: 9925:CHST1
uniprot id: A0A452DXK3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
messages: Membrane

9925:EML5
gene id: 9925:EML5
uniprot id: A0A452F503
uniprot id: A0A452F555
names: Function
names: Similarity
messages: Belongs to the WD repeat EMAP family.
messages: May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

9925:CASQ2
gene id: 9925:CASQ2
uniprot id: A0A452EKU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calsequestrin family.
messages: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.
messages: Sarcoplasmic reticulum lumen

9925:CMTM6
gene id: 9925:CMTM6
uniprot id: A0A452E5C6
names: Subcellular Location Annotation
messages: Membrane

9925:FIBIN
gene id: 9925:FIBIN
uniprot id: A0A452DSW9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FIBIN family.
messages: Endoplasmic reticulum
messages: Golgi apparatus
messages: Homodimer; disulfide-linked. Seems to also exist as monomers.
messages: Secreted

9925:FIP1L1
gene id: 9925:FIP1L1
uniprot id: A0A452G507
uniprot id: A0A452G559
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FIP1 family.
messages: Nucleus

9925:NR4A2
gene id: 9925:NR4A2
uniprot id: A0A452EDZ0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the nuclear hormone receptor family.
messages: Cytoplasm
messages: Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.
messages: Nucleus

9925:UBAP2
gene id: 9925:UBAP2
uniprot id: A0A452FTW7
names: Subcellular Location Annotation
messages: Cytoplasm

9925:GALNT14
gene id: 9925:GALNT14
uniprot id: A0A452EAC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9925:SYCE1
gene id: 9925:SYCE1
uniprot id: A0A8C2R3K4
names: Similarity
messages: Belongs to the SYCE family.

9925:EMC7
gene id: 9925:EMC7
uniprot id: A0A452FE61
names: Similarity
names: Subunit
messages: Belongs to the EMC7 family.
messages: Component of the ER membrane protein complex (EMC).

9925:CRKL
gene id: 9925:CRKL
uniprot id: A0A452DSI4
names: Similarity
messages: Belongs to the CRK family.

9925:GANAB
gene id: 9925:GANAB
uniprot id: A0A452FP43
uniprot id: A0A452FP74
names: Similarity
messages: Belongs to the glycosyl hydrolase 31 family.

9925:TFAP2E
gene id: 9925:TFAP2E
uniprot id: A0A452FK36
names: Similarity
messages: Belongs to the AP-2 family.

9925:RRP1
gene id: 9925:RRP1
uniprot id: A0A452FGB8
names: Similarity
messages: Belongs to the RRP1 family.

9925:GPT2
gene id: 9925:GPT2
uniprot id: A0A452GAD8
names: Similarity
names: Subunit
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
messages: Homodimer.

9925:PRKAB1
gene id: 9925:PRKAB1
uniprot id: A0A452FIT0
names: Function
names: Similarity
messages: Belongs to the 5'-AMP-activated protein kinase beta subunit family.
messages: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

9925:EP300
gene id: 9925:EP300
uniprot id: A0A452F2D2
uniprot id: A0A452F2F6
names: Subcellular Location Annotation
messages: Cytoplasm

9925:PSKH1
gene id: 9925:PSKH1
uniprot id: A0A452FPP7
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:RPS10
gene id: 9925:RPS10
uniprot id: A5JST4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS10 family.

9925:KCNE2
gene id: 9925:KCNE2
uniprot id: A0A452DSG8
names: Similarity
messages: Belongs to the potassium channel KCNE family.

9925:TNFSF10
gene id: 9925:TNFSF10
uniprot id: A0A452EXA6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tumor necrosis factor family.
messages: Homotrimer.
messages: Membrane
messages: Secreted

9925:UTP15
gene id: 9925:UTP15
uniprot id: A0A452EXS0
names: Subcellular Location Annotation
messages: nucleolus

9925:LOC102181033
gene id: 9925:LOC102181033
uniprot id: A0A452DY92
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:N6AMT1
gene id: 9925:N6AMT1
uniprot id: A0A452EV03
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

9925:SLC26A3
gene id: 9925:SLC26A3
uniprot id: A0A452GB98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
messages: Membrane

9925:FEZ1
gene id: 9925:FEZ1
uniprot id: A0A452ET64
names: Similarity
messages: Belongs to the zygin family.

9925:SEBOX
gene id: 9925:SEBOX
uniprot id: A0A452G0N1
names: Subcellular Location Annotation
messages: Nucleus

9925:DTNB
gene id: 9925:DTNB
uniprot id: A0A452E4X9
uniprot id: A0A452E4Z8
uniprot id: A0A452E517
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dystrophin family. Dystrobrevin subfamily.
messages: Cytoplasm

9925:LOC102183964
gene id: 9925:LOC102183964
uniprot id: A0A452DRZ5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:MC4R
gene id: 9925:MC4R
uniprot id: G1EIN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).

9925:SOX12
gene id: 9925:SOX12
uniprot id: A0A452DWF2
names: Subcellular Location Annotation
messages: Nucleus

9925:CHRNA3
gene id: 9925:CHRNA3
uniprot id: A0A452ELM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:LOC102182294
gene id: 9925:LOC102182294
uniprot id: A0A452DL40
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.
messages: Membrane
messages: Microsome membrane
messages: Mitochondrion inner membrane
messages: The omega-1 hydroxylase activity is stimulated by cytochrome b5.

9925:LOC102170932
gene id: 9925:LOC102170932
uniprot id: A0A452E0H2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CCDC25 family.
messages: Cell membrane
messages: Endomembrane system
messages: Interacts (via cytoplasmic region) with ILK.

9925:NDUFS6
gene id: 9925:NDUFS6
uniprot id: A0A452FDC1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFS6 subunit family.
messages: Mitochondrion inner membrane

9925:ST6GALNAC5
gene id: 9925:ST6GALNAC5
uniprot id: A0A452EW14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9925:CES5A
gene id: 9925:CES5A
uniprot id: A0A452FQP6
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

9925:ARL2
gene id: 9925:ARL2
uniprot id: A0A452FH66
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Arf family.
messages: centrosome

9925:C7H19orf53
gene id: 9925:C7H19orf53
uniprot id: A0A452F347
names: Function
names: Similarity
messages: Belongs to the UPF0390 family.
messages: May have a potential role in hypercalcemia of malignancy.

9925:LOC108633423
gene id: 9925:LOC108633423
uniprot id: A0A452DSS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:POC5
gene id: 9925:POC5
uniprot id: A0A452DZ68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POC5 family.
messages: Essential for the assembly of the distal half of centrioles, required for centriole elongation.
messages: centriole

9925:RUNX1T1
gene id: 9925:RUNX1T1
uniprot id: A0A452EJP0
uniprot id: A0A452EJU7
uniprot id: A0A452EJY7
names: Similarity
messages: Belongs to the CBFA2T family.

9925:ASIC1
gene id: 9925:ASIC1
uniprot id: A0A452G5G4
names: Subcellular Location Annotation
messages: Membrane

9925:PRDM8
gene id: 9925:PRDM8
uniprot id: A0A452F8M9
names: Subcellular Location Annotation
messages: Nucleus

9925:ZSCAN26
gene id: 9925:ZSCAN26
uniprot id: A0A452EEV1
names: Subcellular Location Annotation
messages: Nucleus

9925:CLCNKA
gene id: 9925:CLCNKA
uniprot id: A0A452G531
names: Subcellular Location Annotation
messages: Membrane

9925:MAP2K6
gene id: 9925:MAP2K6
uniprot id: A0A452FY29
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:LOC102183207
gene id: 9925:LOC102183207
uniprot id: A0A452E109
names: Similarity
messages: Belongs to the peptidase M14 family.

9925:PIK3C3
gene id: 9925:PIK3C3
uniprot id: A0A452ERG8
uniprot id: A0A452ERQ4
uniprot id: A0A452ERU8
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9925:LOC102177244
gene id: 9925:LOC102177244
uniprot id: A0A452DSL4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

9925:DPP4
gene id: 9925:DPP4
uniprot id: A0A452FGG5
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Belongs to the peptidase S9B family. DPPIV subfamily.
messages: Cell junction
messages: Cell membrane
messages: Membrane raft
messages: invadopodium membrane
messages: lamellipodium membrane

9925:CSNK2A2
gene id: 9925:CSNK2A2
uniprot id: A0A452FFM4
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:SEMA6D
gene id: 9925:SEMA6D
uniprot id: A0A452ED00
uniprot id: A0A452ED64
uniprot id: A0A452EDH3
uniprot id: A0A8C2NSL3
uniprot id: A0A8C2NUH6
uniprot id: A0A8C2NW84
uniprot id: A0A8C2QUT6
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:EIF2B5
gene id: 9925:EIF2B5
uniprot id: A0A452G622
uniprot id: A0A8C2RDW7
names: Similarity
messages: Belongs to the eIF-2B gamma/epsilon subunits family.

9925:AGO2
gene id: 9925:AGO2
uniprot id: A0A452E3F5
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argonaute family. Ago subfamily.
messages: Hydroxylated. 4-hydroxylation appears to enhance protein stability but is not required for miRNA-binding or endonuclease activity.
messages: Interacts with DICER1 through its Piwi domain and with TARBP2 during assembly of the RNA-induced silencing complex (RISC). Together, DICER1, AGO2 and TARBP2 constitute the trimeric RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC). Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Note however that the term RISC has also been used to describe the trimeric RLC/miRLC. The formation of RISC complexes containing siRNAs rather than miRNAs appears to occur independently of DICER1. Interacts with AGO1. Also interacts with DDB1, DDX5, DDX6, DDX20, DHX30, DHX36, DDX47, DHX9, ELAVL, FXR1, GEMIN4, HNRNPF, IGF2BP1, ILF3, IMP8, MATR3, PABPC1, PRMT5, P4HA1, P4HB, RBM4, SART3, TNRC6A, TNRC6B, UPF1 and YBX1. Interacts with the P-body components DCP1A and XRN1. Associates with polysomes and messenger ribonucleoproteins (mNRPs). Interacts with RBM4; the interaction is modulated under stress-induced conditions, occurs under both cell proliferation and differentiation conditions and in an RNA-and phosphorylation-independent manner. Interacts with LIMD1, WTIP and AJUBA. Interacts with TRIM71. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with APOBEC3A, APOBEC3C, APOBEC3F and APOBEC3H. Interacts with DICER1, TARBP2, EIF6, MOV10 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC). Interacts with FMR1. Interacts with ZFP36.
messages: Nucleus
messages: P-body
messages: Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions.
messages: The Piwi domain may perform RNA cleavage by a mechanism similar to that of RNase H. However, while RNase H utilizes a triad of Asp-Asp-Glu (DDE) for metal ion coordination, this protein appears to utilize a triad of Asp-Asp-His (DDH).

9925:SLC1A6
gene id: 9925:SLC1A6
uniprot id: A0A452E0T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
messages: Membrane

9925:CALB1
gene id: 9925:CALB1
uniprot id: A0A452FGU7
names: Function
names: Similarity
messages: Belongs to the calbindin family.
messages: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

9925:CNOT6L
gene id: 9925:CNOT6L
uniprot id: A0A452DSF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCR4/nocturin family.
messages: Cytoplasm
messages: Nucleus

9925:ARL5A
gene id: 9925:ARL5A
uniprot id: A0A452G2A5
names: Similarity
messages: Belongs to the small GTPase superfamily. Arf family.

9925:HIBCH
gene id: 9925:HIBCH
uniprot id: A0A452FTN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enoyl-CoA hydratase/isomerase family.
messages: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.
messages: Mitochondrion

9925:STEAP2
gene id: 9925:STEAP2
uniprot id: A0A452FEV1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STEAP family.
messages: Endosome membrane
messages: Membrane

9925:EMSY
gene id: 9925:EMSY
uniprot id: A0A452EUK7
uniprot id: A0A452EUM4
uniprot id: A0A452EUR5
names: Subcellular Location Annotation
messages: Nucleus

9925:NADK
gene id: 9925:NADK
uniprot id: A0A452FTW8
names: Similarity
messages: Belongs to the NAD kinase family.

9925:EMC8
gene id: 9925:EMC8
uniprot id: A0A452FF87
names: Similarity
messages: Belongs to the EMC8/EMC9 family.

9925:LOC102183344
gene id: 9925:LOC102183344
uniprot id: A0A452E253
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TFCP2
gene id: 9925:TFCP2
uniprot id: A0A452FLV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the grh/CP2 family. CP2 subfamily.
messages: Nucleus

9925:ABR
gene id: 9925:ABR
uniprot id: A0A452FVU2
uniprot id: A0A452FVU7
names: Subcellular Location Annotation
messages: Synapse
messages: axon
messages: dendritic spine

9925:ZDHHC13
gene id: 9925:ZDHHC13
uniprot id: A0A452G0P0
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Cytoplasmic vesicle membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9925:UMPS
gene id: 9925:UMPS
uniprot id: A0A452G195
names: Similarity
messages: In the C-terminal section; belongs to the OMP decarboxylase family.
messages: In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

9925:S100A16
gene id: 9925:S100A16
uniprot id: A0A452G7N6
names: Similarity
messages: Belongs to the S-100 family.

9925:RDH13
gene id: 9925:RDH13
uniprot id: A0A452F855
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:UNC45A
gene id: 9925:UNC45A
uniprot id: A0A452FHK1
names: Subcellular Location Annotation
messages: perinuclear region

9925:PGM1
gene id: 9925:PGM1
uniprot id: A0A452F6I3
uniprot id: A0A452F6J5
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9925:AOC1
gene id: 9925:AOC1
uniprot id: A0A452F849
names: Cofactor
names: PTM
names: Similarity
messages: Belongs to the copper/topaquinone oxidase family.
messages: Contains 1 topaquinone per subunit.
messages: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.

9925:NFE2L1
gene id: 9925:NFE2L1
uniprot id: A0A452EQK7
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

9925:DDIT3
gene id: 9925:DDIT3
uniprot id: M1PEQ4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bZIP family.
messages: Cytoplasm
messages: Heterodimer.
messages: Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
messages: Nucleus
messages: Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.
messages: Ubiquitinated, leading to its degradation by the proteasome.

9925:IPO5
gene id: 9925:IPO5
uniprot id: A0A452F3M1
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:TRADD
gene id: 9925:TRADD
uniprot id: A0A452G086
names: Subcellular Location Annotation
messages: Nucleus
messages: cytoskeleton

9925:CSTA
gene id: 9925:CSTA
uniprot id: A0A452EZ91
names: Similarity
messages: Belongs to the cystatin family.

9925:CD164L2
gene id: 9925:CD164L2
uniprot id: A0A452FVU6
uniprot id: A0A8C2QSE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CD164 family.
messages: Membrane

9925:PATZ1
gene id: 9925:PATZ1
uniprot id: A0A452FCX8
uniprot id: A0A452FCY6
uniprot id: A0A8C2Y169
names: Subcellular Location Annotation
messages: Nucleus

9925:STOML2
gene id: 9925:STOML2
uniprot id: A0A452G4H8
names: Similarity
messages: Belongs to the band 7/mec-2 family.

9925:TYMS
gene id: 9925:TYMS
uniprot id: A0A452DJT2
names: Similarity
messages: Belongs to the thymidylate synthase family.

9925:TBX19
gene id: 9925:TBX19
uniprot id: A0A452EJ52
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Nucleus

9925:LOC102172792
gene id: 9925:LOC102172792
uniprot id: A0A452EUX6
names: Similarity
messages: Belongs to the peptidase A1 family.

9925:GNG11
gene id: 9925:GNG11
uniprot id: A0A452FZE2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G protein gamma family.
messages: Cell membrane
messages: G proteins are composed of 3 units; alpha, beta and gamma.
messages: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

9925:OLFM1
gene id: 9925:OLFM1
uniprot id: A0A452E8C9
names: Subcellular Location Annotation
messages: Secreted
messages: Synapse

9925:LDB1
gene id: 9925:LDB1
uniprot id: A0A452EB14
names: Similarity
messages: Belongs to the LDB family.

9925:AGBL5
gene id: 9925:AGBL5
uniprot id: A0A452ECH3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Midbody
messages: Nucleus
messages: cytosol
messages: spindle

9925:PDS5A
gene id: 9925:PDS5A
uniprot id: A0A452G6A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PDS5 family.
messages: Nucleus

9925:ATIC
gene id: 9925:ATIC
uniprot id: A0A452F6I8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PurH family.
messages: cytosol

9925:GMNN
gene id: 9925:GMNN
uniprot id: A0A452FAV7
uniprot id: A0A8C2RHY1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the geminin family.
messages: Nucleus

9925:TAF11
gene id: 9925:TAF11
uniprot id: A0A452FY55
names: Similarity
messages: Belongs to the TAF11 family.

9925:RPS13
gene id: 9925:RPS13
uniprot id: A0A452FSE1
names: Similarity
messages: Belongs to the universal ribosomal protein uS15 family.

9925:PAN3
gene id: 9925:PAN3
uniprot id: A0A452E5Z5
uniprot id: A0A452E603
uniprot id: A0A452E608
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. PAN3 family.
messages: Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.
messages: Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PABPC1 (via PABC domain), conferring substrate specificity of the enzyme complex. Interacts with the GW182 family proteins TNRC6A, TNRC6B and TNRC6C.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: P-body
messages: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.
messages: The N-terminal zinc finger binds to poly(A) RNA.
messages: The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.

9925:PGM2L1
gene id: 9925:PGM2L1
uniprot id: A0A452G4Z6
names: Similarity
messages: Belongs to the phosphohexose mutase family.

9925:GUCA2B
gene id: 9925:GUCA2B
uniprot id: A0A452FAQ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylin family.
messages: Secreted

9925:CCNE2
gene id: 9925:CCNE2
uniprot id: A0A452FPZ6
names: Similarity
messages: Belongs to the cyclin family.

9925:BFSP1
gene id: 9925:BFSP1
uniprot id: A0A452G3W4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: cell cortex
messages: cytoskeleton

9925:LOC102182663
gene id: 9925:LOC102182663
uniprot id: A5HEW1
uniprot id: Q9N0U7
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
messages: Belongs to the cytochrome P450 family.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane
messages: Regulated predominantly by intracellular cAMP levels. The 17,20-lyase activity is stimulated by cytochrome b5, which acts as an allosteric effector increasing the Vmax of the lyase activity.

9925:MRPS7
gene id: 9925:MRPS7
uniprot id: A0A452G9S0
names: Similarity
messages: Belongs to the universal ribosomal protein uS7 family.

9925:ADGRL4
gene id: 9925:ADGRL4
uniprot id: A0A452FC38
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:IL12B
gene id: 9925:IL12B
uniprot id: P68221
uniprot id: Q6E218
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).
messages: Belongs to the IL-12B family.
messages: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.
messages: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer. Interacts with NBR1; this interaction promotes IL-12 secretion (By similarity).
messages: Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer. Interacts with NBR1; this interaction promotes IL-12 secretion.
messages: Secreted

9925:TBRG1
gene id: 9925:TBRG1
uniprot id: A0A452FEF0
names: Subcellular Location Annotation
messages: Nucleus

9925:CCT2
gene id: 9925:CCT2
uniprot id: A0A452G4D6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCP-1 chaperonin family.
messages: Cytoplasm

9925:USH1G
gene id: 9925:USH1G
uniprot id: A0A452E4X0
names: Function
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9925:LOC102181343
gene id: 9925:LOC102181343
uniprot id: A0A452E3C0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL22 family.

9925:GABRB2
gene id: 9925:GABRB2
uniprot id: A0A452G0D4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:REXO2
gene id: 9925:REXO2
uniprot id: A0A452DZQ7
names: Similarity
messages: Belongs to the oligoribonuclease family.

9925:IL15
gene id: 9925:IL15
uniprot id: A0A452FXZ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-15/IL-21 family.
messages: Secreted

9925:TFRC
gene id: 9925:TFRC
uniprot id: A0A452GAA0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M28 family. M28B subfamily.
messages: Cell membrane
messages: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.
messages: Homodimer; disulfide-linked.
messages: Melanosome
messages: Membrane
messages: Stearoylated.

9925:SEPT11
gene id: 9925:SEPT11
uniprot id: A0A452FGM9
uniprot id: A0A8C2NBQ8
uniprot id: A0A8C2NBS0
uniprot id: A0A8C2QRP1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Filament-forming cytoskeletal GTPase.
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.

9925:OLFML3
gene id: 9925:OLFML3
uniprot id: A0A452G3W0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LSM14B
gene id: 9925:LSM14B
uniprot id: A0A452E381
uniprot id: A0A452E392
names: Similarity
messages: Belongs to the LSM14 family.

9925:TSPYL5
gene id: 9925:TSPYL5
uniprot id: A0A452DWU4
names: Similarity
messages: Belongs to the nucleosome assembly protein (NAP) family.

9925:LOC102169399
gene id: 9925:LOC102169399
uniprot id: A0A452G2X4
names: Similarity
messages: Belongs to the Arg-specific ADP-ribosyltransferase family.

9925:LEPROT
gene id: 9925:LEPROT
uniprot id: A0A8C2QTL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OB-RGRP/VPS55 family.
messages: Membrane

9925:PIK3C2A
gene id: 9925:PIK3C2A
uniprot id: A0A452ENZ1
names: Similarity
messages: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.

9925:MPDU1
gene id: 9925:MPDU1
uniprot id: A0A452F8I1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MPDU1 (TC 2.A.43.3) family.
messages: Membrane
messages: Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors.

9925:CCND2
gene id: 9925:CCND2
uniprot id: A0A452G0W2
names: Similarity
messages: Belongs to the cyclin family.

9925:IK
gene id: 9925:IK
uniprot id: A0A8C2QX97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RED family.
messages: Nucleus

9925:REEP5
gene id: 9925:REEP5
uniprot id: A0A452FHI3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DP1 family.
messages: Membrane

9925:AQP6
gene id: 9925:AQP6
uniprot id: A0A452EHG4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9925:ATP6V1B1
gene id: 9925:ATP6V1B1
uniprot id: A0A452EKE7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Apical cell membrane
messages: Belongs to the ATPase alpha/beta chains family.
messages: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.
messages: V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.

9925:AP3D1
gene id: 9925:AP3D1
uniprot id: A0A452FXQ1
names: Similarity
messages: Belongs to the adaptor complexes large subunit family.

9925:LOC102183481
gene id: 9925:LOC102183481
uniprot id: A0A452ERP3
names: Similarity
messages: Belongs to the neutral ceramidase family.

9925:LSM5
gene id: 9925:LSM5
uniprot id: A0A452FYD5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the snRNP Sm proteins family.
messages: LSm subunits form a heteromer with a doughnut shape.
messages: Nucleus
messages: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.

9925:KRT84
gene id: 9925:KRT84
uniprot id: A0A452FY57
names: Similarity
messages: Belongs to the intermediate filament family.

9925:NDC80
gene id: 9925:NDC80
uniprot id: A0A452DL00
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
messages: Belongs to the NDC80/HEC1 family.
messages: Component of the NDC80 complex.
messages: Nucleus
messages: kinetochore

9925:PURG
gene id: 9925:PURG
uniprot id: A0A452FX10
uniprot id: A0A8C2PIW6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PUR DNA-binding protein family.
messages: Nucleus

9925:SEMA3D
gene id: 9925:SEMA3D
uniprot id: A0A452F5B1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the semaphorin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:MAP2K3
gene id: 9925:MAP2K3
uniprot id: A0A452EK95
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:LOC102180752
gene id: 9925:LOC102180752
uniprot id: A0A452DQR0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TRMT13
gene id: 9925:TRMT13
uniprot id: A0A452ER01
names: Function
names: Similarity
messages: Belongs to the methyltransferase TRM13 family.
messages: tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).

9925:FUBP1
gene id: 9925:FUBP1
uniprot id: A0A452EGT8
names: Subcellular Location Annotation
messages: Nucleus

9925:FSCN3
gene id: 9925:FSCN3
uniprot id: A0A452EAN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fascin family.
messages: cytoskeleton

9925:RMI1
gene id: 9925:RMI1
uniprot id: A0A452EEA6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RMI1 family.
messages: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
messages: Nucleus

9925:AEBP1
gene id: 9925:AEBP1
uniprot id: A0A452F924
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M14 family.
messages: Secreted

9925:RIF1
gene id: 9925:RIF1
uniprot id: A0A452FDE0
names: Subcellular Location Annotation
messages: Nucleus
messages: telomere

9925:SIX3
gene id: 9925:SIX3
uniprot id: A0A452E3R7
names: Subcellular Location Annotation
messages: Nucleus

9925:LAMTOR3
gene id: 9925:LAMTOR3
uniprot id: A0A1B2VWD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR3 family.
messages: Endosome membrane
messages: Late endosome membrane

9925:GDF6
gene id: 9925:GDF6
uniprot id: A0A452FA65
names: Similarity
messages: Belongs to the TGF-beta family.

9925:ACVR2A
gene id: 9925:ACVR2A
uniprot id: A0A452EGE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9925:PLCB3
gene id: 9925:PLCB3
uniprot id: A0A452FAC8
names: Cofactor
names: Function
messages: Binds 1 Ca(2+) ion per subunit.
messages: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

9925:PSMB1
gene id: 9925:PSMB1
uniprot id: A0A1Q1N997
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome complex.
messages: Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
messages: Cytoplasm
messages: Nucleus

9925:TLR5
gene id: 9925:TLR5
uniprot id: C0L636
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9925:ACTR8
gene id: 9925:ACTR8
uniprot id: A0A452EQS1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the actin family. ARP8 subfamily.
messages: Chromosome
messages: Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.
messages: Nucleus
messages: Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.
messages: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

9925:C7H5orf30
gene id: 9925:C7H5orf30
uniprot id: A0A452DSA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UNC119-binding protein family.
messages: Cytoplasm
messages: cilium

9925:HOXB8
gene id: 9925:HOXB8
uniprot id: A0A452ERW1
names: Subcellular Location Annotation
messages: Nucleus

9925:PTCH2
gene id: 9925:PTCH2
uniprot id: A0A452F1K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9925:STAT1
gene id: 9925:STAT1
uniprot id: A0A452E166
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transcription factor STAT family.
messages: Cytoplasm
messages: Nucleus

9925:TACR3
gene id: 9925:TACR3
uniprot id: A0A452FE45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:UST
gene id: 9925:UST
uniprot id: A0A452E8G5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 3 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:NR2C1
gene id: 9925:NR2C1
uniprot id: A0A452EKE9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9925:CDH20
gene id: 9925:CDH20
uniprot id: A0A452G978
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9925:PGBD1
gene id: 9925:PGBD1
uniprot id: A0A452EIP3
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102176567
gene id: 9925:LOC102176567
uniprot id: A0A452FQY0
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:BRINP1
gene id: 9925:BRINP1
uniprot id: A0A452E5G9
names: Similarity
messages: Belongs to the BRINP family.

9925:SEPHS1
gene id: 9925:SEPHS1
uniprot id: A0A452GAE9
names: Function
messages: Synthesizes selenophosphate from selenide and ATP.

9925:VIP
gene id: 9925:VIP
uniprot id: A0A452EQ59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glucagon family.
messages: Secreted

9925:SLC25A51
gene id: 9925:SLC25A51
uniprot id: A0A452DVE4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:SRF
gene id: 9925:SRF
uniprot id: A0A452EB23
names: Subcellular Location Annotation
messages: Nucleus

9925:TNN
gene id: 9925:TNN
uniprot id: A0A452EVN2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tenascin family.
messages: extracellular matrix

9925:ASB8
gene id: 9925:ASB8
uniprot id: A0A452E214
names: Function
messages: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

9925:DENND5A
gene id: 9925:DENND5A
uniprot id: A0A452EG69
uniprot id: A0A452EGL0
names: Caution
names: Similarity
messages: Belongs to the RAB6IP1 family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:TNKS2
gene id: 9925:TNKS2
uniprot id: A0A452FI27
names: Function
names: Similarity
messages: Belongs to the ARTD/PARP family.
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9925:EHD1
gene id: 9925:EHD1
uniprot id: A0A452FFI1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Endosome membrane
messages: Membrane

9925:UNC13B
gene id: 9925:UNC13B
uniprot id: A0A452EDY0
names: Subcellular Location Annotation
messages: Cytoplasm

9925:PPP2CA
gene id: 9925:PPP2CA
uniprot id: A0A452FUS0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family.
messages: Cytoplasm

9925:CENPB
gene id: 9925:CENPB
uniprot id: A0A452E632
names: Subcellular Location Annotation
messages: Nucleus

9925:PTK7
gene id: 9925:PTK7
uniprot id: A0A452FAW0
names: Subcellular Location Annotation
messages: Membrane

9925:TRHDE
gene id: 9925:TRHDE
uniprot id: A0A452EA40
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Membrane

9925:CLEC16A
gene id: 9925:CLEC16A
uniprot id: A0A452EKK4
names: Similarity
messages: Belongs to the CLEC16A/gop-1 family.

9925:LASP1
gene id: 9925:LASP1
uniprot id: A0A452FAX2
names: Function
names: Subcellular Location Annotation
messages: Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.
messages: cell cortex
messages: cytoskeleton

9925:STX3
gene id: 9925:STX3
uniprot id: A0A452EXQ4
names: Similarity
messages: Belongs to the syntaxin family.

9925:EFNA2
gene id: 9925:EFNA2
uniprot id: A0A452G6S0
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:NUBP2
gene id: 9925:NUBP2
uniprot id: A0A8C2RXP8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
messages: Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.
messages: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
messages: Cytoplasm
messages: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.
messages: Nucleus
messages: centrosome

9925:TMEM50B
gene id: 9925:TMEM50B
uniprot id: A0A452EDM1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0220 family.
messages: Membrane

9925:P4HA3
gene id: 9925:P4HA3
uniprot id: A0A452FIE0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P4HA family.
messages: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.
messages: Endoplasmic reticulum lumen

9925:SEPT9
gene id: 9925:SEPT9
uniprot id: A0A452G9N2
uniprot id: A0A452GA63
uniprot id: A0A452GA68
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.

9925:ISPD
gene id: 9925:ISPD
uniprot id: A0A452G144
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.
messages: Homodimer.
messages: cytosol

9925:SLC29A1
gene id: 9925:SLC29A1
uniprot id: A0A452FND2
names: Similarity
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Basolateral cell membrane
messages: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
messages: Lateral cell membrane
messages: Membrane

9925:LOC102191315
gene id: 9925:LOC102191315
uniprot id: A0A452ECW5
names: Similarity
messages: Belongs to the peptidase A1 family.

9925:TSR3
gene id: 9925:TSR3
uniprot id: A0A452EVW0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:PMVK
gene id: 9925:PMVK
uniprot id: A0A452FYM9
names: Subcellular Location Annotation
messages: cytosol

9925:NEUROD1
gene id: 9925:NEUROD1
uniprot id: A0A452EGQ4
names: Subcellular Location Annotation
messages: Nucleus

9925:ICMT
gene id: 9925:ICMT
uniprot id: A0A452E9V2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.
messages: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:CTNNBIP1
gene id: 9925:CTNNBIP1
uniprot id: A0A452FWJ1
names: Similarity
messages: Belongs to the CTNNBIP1 family.

9925:POFUT1
gene id: 9925:POFUT1
uniprot id: A0A452FHC7
names: Similarity
messages: Belongs to the glycosyltransferase 65 family.

9925:LOC102181811
gene id: 9925:LOC102181811
uniprot id: A0A452EJH3
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102189835
gene id: 9925:LOC102189835
uniprot id: A0A8C2S238
uniprot id: A0A8C2S2S1
names: Similarity
messages: Belongs to the LDH/MDH superfamily. LDH family.

9925:LOC102171502
gene id: 9925:LOC102171502
uniprot id: A0A452FIE6
uniprot id: A0A452FIG0
uniprot id: A0A452FIZ4
names: Similarity
names: Subunit
messages: Belongs to the RUNDC3 family.
messages: Interacts with RAP2A.

9925:PRDX2
gene id: 9925:PRDX2
uniprot id: A0A452DY24
names: Function
names: Similarity
messages: Belongs to the peroxiredoxin family.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.

9925:CCDC86
gene id: 9925:CCDC86
uniprot id: A0A452ELC9
names: Subcellular Location Annotation
messages: Nucleus

9925:ASPHD1
gene id: 9925:ASPHD1
uniprot id: A0A8C2S8C7
names: Similarity
messages: Belongs to the aspartyl/asparaginyl beta-hydroxylase family.

9925:PLA2G1B
gene id: 9925:PLA2G1B
uniprot id: A0A452E442
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9925:PTCD3
gene id: 9925:PTCD3
uniprot id: A0A452EAC5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mS39 family.
messages: Mitochondrion

9925:GORASP2
gene id: 9925:GORASP2
uniprot id: A0A452EKD0
names: Similarity
messages: Belongs to the GORASP family.

9925:RAB3B
gene id: 9925:RAB3B
uniprot id: A0A452F7P3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9925:STK40
gene id: 9925:STK40
uniprot id: A0A452FGC2
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
messages: Nucleus

9925:TGFB1I1
gene id: 9925:TGFB1I1
uniprot id: A0A8C2RB50
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paxillin family.
messages: cytoskeleton
messages: focal adhesion

9925:MAPRE3
gene id: 9925:MAPRE3
uniprot id: A0A452FLU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

9925:PKNOX1
gene id: 9925:PKNOX1
uniprot id: A0A452FB38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TALE/MEIS homeobox family.
messages: Nucleus

9925:MAPK1IP1L
gene id: 9925:MAPK1IP1L
uniprot id: A0A452EQ07
names: Similarity
messages: Belongs to the MISS family.

9925:LOC102175877
gene id: 9925:LOC102175877
uniprot id: A0A452EF01
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:IMMT
gene id: 9925:IMMT
uniprot id: A0A452G707
uniprot id: A0A452G789
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MICOS complex subunit Mic60 family.
messages: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
messages: Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.
messages: Mitochondrion inner membrane

9925:RBP2
gene id: 9925:RBP2
uniprot id: A0A075VSP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9925:SYNCRIP
gene id: 9925:SYNCRIP
uniprot id: A0A452FZ40
uniprot id: A0A452FZT8
names: Subcellular Location Annotation
messages: Cytoplasm

9925:MAPK8IP1
gene id: 9925:MAPK8IP1
uniprot id: A0A452ERV8
uniprot id: A0A452ERW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JIP scaffold family.
messages: Cytoplasm

9925:SOAT2
gene id: 9925:SOAT2
uniprot id: A0A452G1B8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:KCNQ1
gene id: 9925:KCNQ1
uniprot id: A0A452FFW2
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.1/KCNQ1 sub-subfamily.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Endoplasmic reticulum
messages: Lateral cell membrane
messages: Membrane
messages: Membrane raft

9925:PEBP4
gene id: 9925:PEBP4
uniprot id: A0A452F714
names: Similarity
messages: Belongs to the phosphatidylethanolamine-binding protein family.

9925:SMIM15
gene id: 9925:SMIM15
uniprot id: A0A452DWM7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SMIM15 family.
messages: Membrane

9925:MCM9
gene id: 9925:MCM9
uniprot id: A0A452F4Y7
uniprot id: A0A452F5J2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCM family.
messages: Chromosome
messages: Nucleus

9925:GRM1
gene id: 9925:GRM1
uniprot id: A0A452G1X1
uniprot id: A0A452G284
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family.
messages: Cell membrane
messages: Membrane

9925:LOC102178173
gene id: 9925:LOC102178173
uniprot id: A0A8C2S8T9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:RACK1
gene id: 9925:RACK1
uniprot id: A0A452ESG4
names: Similarity
messages: Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.

9925:NSUN5
gene id: 9925:NSUN5
uniprot id: A0A452EAS7
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9925:DYDC1
gene id: 9925:DYDC1
uniprot id: A0A452E1K8
names: Similarity
messages: Belongs to the dpy-30 family.

9925:CNNM2
gene id: 9925:CNNM2
uniprot id: A0A452EVU5
uniprot id: A0A452EVV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ACDP family.
messages: Cell membrane
messages: Membrane
messages: Metal transporter.

9925:RAD23B
gene id: 9925:RAD23B
uniprot id: A0A452FP98
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAD23 family.
messages: Cytoplasm
messages: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.
messages: Nucleus

9925:LOC102180781
gene id: 9925:LOC102180781
uniprot id: A0A452DLZ4
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:GART
gene id: 9925:GART
uniprot id: A0A452F8K0
names: Similarity
messages: In the C-terminal section; belongs to the GART family.
messages: In the N-terminal section; belongs to the GARS family.
messages: In the central section; belongs to the AIR synthase family.

9925:KCNK12
gene id: 9925:KCNK12
uniprot id: A0A452DYM3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
messages: Membrane

9925:LOC108633281
gene id: 9925:LOC108633281
uniprot id: A0A452DR39
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Cytoplasm
messages: Monomer.

9925:UGGT2
gene id: 9925:UGGT2
uniprot id: A0A452DT37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 8 family.
messages: Endoplasmic reticulum lumen

9925:CHRNG
gene id: 9925:CHRNG
uniprot id: A0A452EM93
uniprot id: A0A8C2N8S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:RHBDL2
gene id: 9925:RHBDL2
uniprot id: A0A452FD68
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S54 family.
messages: Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
messages: Membrane

9925:TMPRSS3
gene id: 9925:TMPRSS3
uniprot id: A0A452E3P5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:ENPEP
gene id: 9925:ENPEP
uniprot id: A0A452FFI8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M1 family.
messages: Binds 1 zinc ion per subunit.
messages: Membrane

9925:TIMM8B
gene id: 9925:TIMM8B
uniprot id: A0A8C2PCD2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the small Tim family.
messages: Heterohexamer.
messages: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
messages: Mitochondrion inner membrane
messages: The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.

9925:SFMBT2
gene id: 9925:SFMBT2
uniprot id: A0A452EGJ7
names: Subcellular Location Annotation
messages: Nucleus

9925:EZR
gene id: 9925:EZR
uniprot id: A0A452F2C6
names: Subcellular Location Annotation
messages: Membrane
messages: cytoskeleton
messages: microvillus

9925:LOC108638299
gene id: 9925:LOC108638299
uniprot id: A0A452DY08
names: Function
messages: The keratin products of mammalian epidermal derivatives such as wool and hair consist of microfibrils embedded in a rigid matrix of other proteins. The matrix proteins include the high-sulfur and high-tyrosine keratins, having molecular weights of 6-20 kDa, whereas the microfibrils contain the larger, low-sulfur keratins (40-56 kDa).

9925:SUPT16H
gene id: 9925:SUPT16H
uniprot id: A0A452E9E4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase M24 family. SPT16 subfamily.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Component of the FACT complex.
messages: Nucleus

9925:TRPT1
gene id: 9925:TRPT1
uniprot id: A0A452FIE9
names: Function
names: Similarity
messages: Belongs to the KptA/TPT1 family.
messages: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.

9925:CCR7
gene id: 9925:CCR7
uniprot id: A0A8C2PE33
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:LOC102181716
gene id: 9925:LOC102181716
uniprot id: A0A452FEA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
messages: myofibril

9925:FGF7
gene id: 9925:FGF7
uniprot id: A0A452ER05
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9925:PNKD
gene id: 9925:PNKD
uniprot id: A0A452DP27
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9925:IL2RA
gene id: 9925:IL2RA
uniprot id: A0A452E014
names: Caution
names: Function
names: Subunit
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.
messages: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.

9925:TMEM265
gene id: 9925:TMEM265
uniprot id: A0A452EEX2
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9925:DDX52
gene id: 9925:DDX52
uniprot id: A0A452DSN4
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9925:KIF24
gene id: 9925:KIF24
uniprot id: A0A452DZU8
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

9925:FGF3
gene id: 9925:FGF3
uniprot id: A0A452DMM2
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9925:PPP1CA
gene id: 9925:PPP1CA
uniprot id: A0A452EER0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PPP phosphatase family. PP-1 subfamily.
messages: nucleolus
messages: nucleoplasm

9925:LOC102170668
gene id: 9925:LOC102170668
uniprot id: A0A452DU43
names: Subcellular Location Annotation
messages: Membrane

9925:FAM46C
gene id: 9925:FAM46C
uniprot id: A0A452DRJ3
names: Similarity
messages: Belongs to the TENT family.

9925:PNLIP
gene id: 9925:PNLIP
uniprot id: A0A8C2XXX7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9925:SHROOM3
gene id: 9925:SHROOM3
uniprot id: A0A452FGS7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the shroom family.
messages: cytoskeleton

9925:ZNF215
gene id: 9925:ZNF215
uniprot id: A0A452EI35
names: Subcellular Location Annotation
messages: Nucleus

9925:AP2M1
gene id: 9925:AP2M1
uniprot id: A0A452F6X6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes medium subunit family.
messages: Cell membrane
messages: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.
messages: coated pit

9925:ACP5
gene id: 9925:ACP5
uniprot id: A0A452EKM6
names: Cofactor
messages: Binds 2 iron ions per subunit.

9925:OSTC
gene id: 9925:OSTC
uniprot id: A0A452ET24
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OSTC family.
messages: Component of the oligosaccharyltransferase (OST) complex.
messages: Membrane
messages: Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

9925:LOC102188304
gene id: 9925:LOC102188304
uniprot id: A0A452E441
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:RAB3D
gene id: 9925:RAB3D
uniprot id: A0A452EMT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Protein transport. Probably involved in vesicular traffic.

9925:LOC102179881
gene id: 9925:LOC102179881
uniprot id: E7FKN1
names: Similarity
messages: Belongs to the intermediate filament family.

9925:LEPR
gene id: 9925:LEPR
uniprot id: A0A452FSY9
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the type I cytokine receptor family. Type 2 subfamily.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9925:LOC102184086
gene id: 9925:LOC102184086
uniprot id: A0A452DPG9
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:NDUFC2
gene id: 9925:NDUFC2
uniprot id: A0A452G0F9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFC2 subunit family.
messages: Mitochondrion inner membrane

9925:F12
gene id: 9925:F12
uniprot id: A0A452DRJ1
names: Caution
names: Subcellular Location Annotation
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Secreted

9925:TSPO
gene id: 9925:TSPO
uniprot id: A0A452EC57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

9925:MYC
gene id: 9925:MYC
uniprot id: A0A452EI51
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Efficient DNA binding requires dimerization with another bHLH protein.
messages: Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform.
messages: nucleolus
messages: nucleoplasm

9925:LAMTOR5
gene id: 9925:LAMTOR5
uniprot id: A0A452EZ49
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR5 family.
messages: Lysosome

9925:RPL38
gene id: 9925:RPL38
uniprot id: A0A8C2SBG0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL38 family.

9925:CCDC85B
gene id: 9925:CCDC85B
uniprot id: A0A452DMT2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC85 family.
messages: adherens junction

9925:LOC102183723
gene id: 9925:LOC102183723
uniprot id: A0A452E9G6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PRUNE1
gene id: 9925:PRUNE1
uniprot id: A0A452E8V1
names: Similarity
messages: Belongs to the PPase class C family. Prune subfamily.

9925:LOC102183966
gene id: 9925:LOC102183966
uniprot id: A0A452EFT9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102177192
gene id: 9925:LOC102177192
uniprot id: A0A452FYA5
names: Similarity
messages: Belongs to the CDC50/LEM3 family.

9925:FAM120B
gene id: 9925:FAM120B
uniprot id: A0A452G7L3
uniprot id: A0A452G7N4
names: Similarity
messages: Belongs to the constitutive coactivator of PPAR-gamma family.

9925:ME1
gene id: 9925:ME1
uniprot id: A0A452FQE3
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

9925:TMED7
gene id: 9925:TMED7
uniprot id: A0A452EK79
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9925:AK3
gene id: 9925:AK3
uniprot id: A0A452FYF6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family. AK3 subfamily.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.
messages: Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
messages: Mitochondrion matrix
messages: Monomer.

9925:ATAD1
gene id: 9925:ATAD1
uniprot id: A0A452FDF4
names: Similarity
messages: Belongs to the AAA ATPase family.

9925:FAM83C
gene id: 9925:FAM83C
uniprot id: A0A452FGH6
names: Similarity
messages: Belongs to the FAM83 family.

9925:NKAIN2
gene id: 9925:NKAIN2
uniprot id: A0A8C2RS27
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NKAIN family.
messages: Cell membrane
messages: Membrane

9925:ERCC5
gene id: 9925:ERCC5
uniprot id: A0A452EKR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
messages: Nucleus

9925:MPP7
gene id: 9925:MPP7
uniprot id: A0A452F6F7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane
messages: adherens junction
messages: tight junction

9925:GDF10
gene id: 9925:GDF10
uniprot id: A0A452E2Q4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer.
messages: Secreted

9925:NAA30
gene id: 9925:NAA30
uniprot id: A0A452ENW7
names: Similarity
messages: Belongs to the acetyltransferase family. MAK3 subfamily.

9925:ELP5
gene id: 9925:ELP5
uniprot id: A0A452E4B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELP5 family.
messages: Cytoplasm
messages: Nucleus

9925:EBPL
gene id: 9925:EBPL
uniprot id: A0A452ELF5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EBP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:USP10
gene id: 9925:USP10
uniprot id: A0A452G532
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family. USP10 subfamily.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9925:SLC4A10
gene id: 9925:SLC4A10
uniprot id: A0A452GB51
uniprot id: A0A452GBD6
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lateral cell membrane
messages: Membrane

9925:MSTN
gene id: 9925:MSTN
uniprot id: A5YU17
uniprot id: Q6T5B8
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts specifically as a negative regulator of skeletal muscle growth.
messages: Belongs to the TGF-beta family.
messages: Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.
messages: Secreted
messages: Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.

9925:ADRA2B
gene id: 9925:ADRA2B
uniprot id: A0A452ES56
uniprot id: A0A8C2QXT8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
messages: Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
messages: Cell membrane
messages: Membrane

9925:RECQL5
gene id: 9925:RECQL5
uniprot id: A0A452E119
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RecQ subfamily.
messages: Nucleus

9925:TIMM22
gene id: 9925:TIMM22
uniprot id: A0A452ET68
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Tim17/Tim22/Tim23 family.
messages: Component of the TIM22 complex.
messages: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.
messages: Membrane
messages: Mitochondrion inner membrane

9925:SPSB4
gene id: 9925:SPSB4
uniprot id: A0A452DX28
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SPSB family.
messages: Cytoplasm

9925:LOC102172278
gene id: 9925:LOC102172278
uniprot id: A0A8C2SCK7
names: Similarity
messages: Belongs to the CBP3 family.

9925:HS3ST2
gene id: 9925:HS3ST2
uniprot id: A0A452DR26
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9925:A1CF
gene id: 9925:A1CF
uniprot id: A0A452FDW8
names: Subcellular Location Annotation
messages: Cytoplasm

9925:LOC102173092
gene id: 9925:LOC102173092
uniprot id: A0A452DQY7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SCAMP5
gene id: 9925:SCAMP5
uniprot id: A0A452F6D3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SCAMP family.
messages: Membrane

9925:LOC102172226
gene id: 9925:LOC102172226
uniprot id: A0A452EHW1
names: Similarity
messages: Belongs to the histone H2B family.

9925:PRPF38A
gene id: 9925:PRPF38A
uniprot id: A0A452FZB1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRP38 family.
messages: Component of the spliceosome B complex.
messages: Involved in pre-mRNA splicing as a component of the spliceosome.
messages: Nucleus

9925:LOC102185156
gene id: 9925:LOC102185156
uniprot id: A0A452EX01
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9925:C23H6orf89
gene id: 9925:C23H6orf89
uniprot id: A0A452FW45
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Golgi apparatus membrane
messages: Membrane

9925:MLLT11
gene id: 9925:MLLT11
uniprot id: A0A452DML1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLLT11 family.
messages: Nucleus
messages: centrosome

9925:DHRS7B
gene id: 9925:DHRS7B
uniprot id: A0A8C2P928
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:LRRC8C
gene id: 9925:LRRC8C
uniprot id: A0A8C2R1E9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LRRC8 family.
messages: Cell membrane
messages: Membrane

9925:IFNGR1
gene id: 9925:IFNGR1
uniprot id: A0A452EHZ9
names: Similarity
messages: Belongs to the type II cytokine receptor family.

9925:CLEC12B
gene id: 9925:CLEC12B
uniprot id: A0A452E8H9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:GDF9
gene id: 9925:GDF9
uniprot id: B7U4A2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.
messages: Secreted

9925:PPIC
gene id: 9925:PPIC
uniprot id: A0A452ENM1
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9925:GSS
gene id: 9925:GSS
uniprot id: A0A452G5S8
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic GSH synthase family.
messages: Binds 1 Mg(2+) ion per subunit.

9925:PELI1
gene id: 9925:PELI1
uniprot id: A0A452FM66
uniprot id: A0A8C2QSV9
names: Function
names: Similarity
messages: Belongs to the pellino family.
messages: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

9925:ITM2C
gene id: 9925:ITM2C
uniprot id: A0A452FAP6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ITM2 family.
messages: Membrane

9925:LIMK2
gene id: 9925:LIMK2
uniprot id: A0A452F3K2
names: Similarity
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

9925:SV2C
gene id: 9925:SV2C
uniprot id: A0A452EWI7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9925:ST3GAL6
gene id: 9925:ST3GAL6
uniprot id: A0A452EGP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9925:TMEM41B
gene id: 9925:TMEM41B
uniprot id: A0A452ETA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM41 family.
messages: Membrane

9925:ZDHHC12
gene id: 9925:ZDHHC12
uniprot id: A0A452G7E2
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9925:FAM91A1
gene id: 9925:FAM91A1
uniprot id: A0A452DYX3
names: Similarity
messages: Belongs to the FAM91 family.

9925:CHRNA4
gene id: 9925:CHRNA4
uniprot id: A0A452FS60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
messages: Cell membrane
messages: Membrane
messages: Postsynaptic cell membrane
messages: Synaptic cell membrane

9925:C24H18orf21
gene id: 9925:C24H18orf21
uniprot id: A0A452FWV1
names: Similarity
messages: Belongs to the UPF0711 family.

9925:MON1B
gene id: 9925:MON1B
uniprot id: A0A452FFS3
names: Function
names: Similarity
messages: Belongs to the MON1/SAND family.
messages: Plays an important role in membrane trafficking through the secretory apparatus.

9925:IKBKB
gene id: 9925:IKBKB
uniprot id: A0A452EKT6
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:GATAD2B
gene id: 9925:GATAD2B
uniprot id: A0A452F0L4
uniprot id: A0A8C2REB1
names: Subcellular Location Annotation
messages: Nucleus

9925:PARPBP
gene id: 9925:PARPBP
uniprot id: A0A452FRI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PARI family.
messages: Cytoplasm
messages: Nucleus

9925:INO80
gene id: 9925:INO80
uniprot id: A0A452E3G3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Component of the INO80 chromatin-remodeling complex.
messages: Nucleus
messages: The DBINO region is involved in binding to DNA.

9925:LOC102176495
gene id: 9925:LOC102176495
uniprot id: A0A452DJW6
names: Domain
names: Similarity
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.

9925:AKR1E2
gene id: 9925:AKR1E2
uniprot id: A0A452DP80
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9925:MED24
gene id: 9925:MED24
uniprot id: A0A452FBA6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 24 family.
messages: Nucleus

9925:KLC3
gene id: 9925:KLC3
uniprot id: A0A452G729
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9925:AGA
gene id: 9925:AGA
uniprot id: A0A452DS23
names: Similarity
messages: Belongs to the Ntn-hydrolase family.

9925:LOC102171837
gene id: 9925:LOC102171837
uniprot id: A0A8C2NYD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ran family.
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: Nucleus

9925:NRCAM
gene id: 9925:NRCAM
uniprot id: A0A452G9B2
names: Similarity
messages: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

9925:ACKR3
gene id: 9925:ACKR3
uniprot id: A0A452DNS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:HOXB7
gene id: 9925:HOXB7
uniprot id: A0A452F107
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family.
messages: Nucleus

9925:POLR3D
gene id: 9925:POLR3D
uniprot id: A0A452EBL3
names: Subcellular Location Annotation
messages: Nucleus

9925:CLUH
gene id: 9925:CLUH
uniprot id: A0A452DQ90
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CLU family.
messages: Cytoplasm
messages: Cytoplasmic granule
messages: mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis.

9925:RNASE10
gene id: 9925:RNASE10
uniprot id: A0A452DN90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9925:CCDC181
gene id: 9925:CCDC181
uniprot id: A0A452EEL8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CCDC181 family.
messages: Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.
messages: cytoskeleton

9925:UBE2M
gene id: 9925:UBE2M
uniprot id: A0A452EWN3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9925:USP13
gene id: 9925:USP13
uniprot id: A0A452FCT8
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9925:KEF96 p12
gene id: 9925:KEF96_p12
uniprot id: D0VEF5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242.
messages: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
messages: Membrane
messages: Mitochondrion inner membrane

9925:GPR87
gene id: 9925:GPR87
uniprot id: A0A452G8D0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:TMEM2
gene id: 9925:TMEM2
uniprot id: A0A452G4K9
names: Similarity
messages: Belongs to the CEMIP family.

9925:PAQR3
gene id: 9925:PAQR3
uniprot id: A0A452EFD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9925:PLXDC2
gene id: 9925:PLXDC2
uniprot id: A0A452FUB3
names: Subcellular Location Annotation
messages: Membrane

9925:ACSM4
gene id: 9925:ACSM4
uniprot id: A0A452F6C5
names: Similarity
messages: Belongs to the ATP-dependent AMP-binding enzyme family.

9925:MLF2
gene id: 9925:MLF2
uniprot id: A0A452EKA5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MLF family.
messages: Cytoplasm

9925:SLC2A3
gene id: 9925:SLC2A3
uniprot id: D4P8R9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
messages: Cell membrane
messages: Cell projection
messages: Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Perikaryon
messages: Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.

9925:EVA1B
gene id: 9925:EVA1B
uniprot id: A0A452E822
names: Similarity
messages: Belongs to the EVA1 family.

9925:RFNG
gene id: 9925:RFNG
uniprot id: A0A452G5I0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:LOC102180151
gene id: 9925:LOC102180151
uniprot id: A0A452F893
names: Subcellular Location Annotation
messages: Membrane

9925:IFT43
gene id: 9925:IFT43
uniprot id: A0A452E8L8
names: Similarity
messages: Belongs to the IFT43 family.

9925:NPC1L1
gene id: 9925:NPC1L1
uniprot id: A0A452EN38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the patched family.
messages: Membrane

9925:EIF1AD
gene id: 9925:EIF1AD
uniprot id: A0A452EHP6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the EIF1AD family.
messages: Interacts with GAPDH and STAT1.
messages: Plays a role into cellular response to oxidative stress. Decreases cell proliferation.

9925:ZC3H12D
gene id: 9925:ZC3H12D
uniprot id: A0A452G5G5
names: Similarity
messages: Belongs to the ZC3H12 family.

9925:GPR20
gene id: 9925:GPR20
uniprot id: A0A452DYW4
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:SNX8
gene id: 9925:SNX8
uniprot id: A0A452FK80
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sorting nexin family.
messages: Membrane

9925:ENO4
gene id: 9925:ENO4
uniprot id: A0A452F935
names: Similarity
messages: Belongs to the enolase family.

9925:CPSF2
gene id: 9925:CPSF2
uniprot id: A0A452FVM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.
messages: Nucleus

9925:TMEM106B
gene id: 9925:TMEM106B
uniprot id: A0A8C2N9E4
names: Similarity
messages: Belongs to the TMEM106 family.

9925:CPSF7
gene id: 9925:CPSF7
uniprot id: A0A452ELZ0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRM CPSF6/7 family.
messages: Nucleus

9925:LOC102168248
gene id: 9925:LOC102168248
uniprot id: A0A452EDT6
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:FGD6
gene id: 9925:FGD6
uniprot id: A0A452FDK8
names: Subcellular Location Annotation
messages: cytoskeleton

9925:LOC102172376
gene id: 9925:LOC102172376
uniprot id: A0A8C2RGE0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 6A family.
messages: Membrane
messages: Mitochondrion inner membrane

9925:NDUFAF4
gene id: 9925:NDUFAF4
uniprot id: A0A452FB70
names: Similarity
names: Subunit
messages: Belongs to the NDUFAF4 family.
messages: Binds calmodulin. Interacts with NDUFAF3.

9925:FAM19A1
gene id: 9925:FAM19A1
uniprot id: A0A8C2PHQ4
names: Similarity
messages: Belongs to the TAFA family.

9925:PLPPR5
gene id: 9925:PLPPR5
uniprot id: A0A452G5B7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9925:APOM
gene id: 9925:APOM
uniprot id: A0A452DQJ9
uniprot id: A0A8C2RS10
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
messages: Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.
messages: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
messages: Secreted

9925:LOC102174664
gene id: 9925:LOC102174664
uniprot id: A0A452EH73
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pancreatic ribonuclease family.
messages: Secreted

9925:S100A4
gene id: 9925:S100A4
uniprot id: A0A452G2G1
names: Similarity
messages: Belongs to the S-100 family.

9925:BMPR1A
gene id: 9925:BMPR1A
uniprot id: A0A452DLL6
uniprot id: G3LUU9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9925:METTL4
gene id: 9925:METTL4
uniprot id: A0A452DKJ1
uniprot id: A0A8C2RR17
names: Similarity
messages: Belongs to the MT-A70-like family.

9925:SPDEF
gene id: 9925:SPDEF
uniprot id: A0A8C2XV59
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ETS family.
messages: Nucleus

9925:GPR156
gene id: 9925:GPR156
uniprot id: A0A452FJ38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.
messages: Cell membrane
messages: Membrane

9925:GSC
gene id: 9925:GSC
uniprot id: A0A452FMK4
names: Subcellular Location Annotation
messages: Nucleus

9925:E2F6
gene id: 9925:E2F6
uniprot id: A0A8C2Y297
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9925:INHBC
gene id: 9925:INHBC
uniprot id: A0A452F1N2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TGF-beta family.
messages: Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.
messages: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
messages: Secreted

9925:LOC108633170
gene id: 9925:LOC108633170
uniprot id: A0A452DQ46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9925:CLK4
gene id: 9925:CLK4
uniprot id: A0A452F9Z6
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:LOC102184211
gene id: 9925:LOC102184211
uniprot id: A0A452FFG9
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
messages: Membrane
messages: desmosome

9925:STX16
gene id: 9925:STX16
uniprot id: A0A452EPT6
names: Similarity
messages: Belongs to the syntaxin family.

9925:LOC102178345
gene id: 9925:LOC102178345
uniprot id: A0A452ED28
names: Similarity
messages: Belongs to the peptidase A1 family.

9925:ACAA1
gene id: 9925:ACAA1
uniprot id: A0A452E401
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9925:TRUB1
gene id: 9925:TRUB1
uniprot id: A0A452FGD3
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family.

9925:LOC102168475
gene id: 9925:LOC102168475
uniprot id: A0A452EBU3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:BBS2
gene id: 9925:BBS2
uniprot id: A0A452FF41
names: Subcellular Location Annotation
messages: centriolar satellite
messages: cilium membrane

9925:ADAMTS6
gene id: 9925:ADAMTS6
uniprot id: A0A452FXW5
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:ADGRA3
gene id: 9925:ADGRA3
uniprot id: A0A452FBU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
messages: Membrane

9925:ALKBH8
gene id: 9925:ALKBH8
uniprot id: A0A452DXR0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alkB family.
messages: Cytoplasm

9925:ALDH2
gene id: 9925:ALDH2
uniprot id: A0A452FSS5
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9925:TM4SF4
gene id: 9925:TM4SF4
uniprot id: A0A452DWC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9925:CORIN
gene id: 9925:CORIN
uniprot id: A0A452DVD4
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:E2F3
gene id: 9925:E2F3
uniprot id: A0A452E4U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9925:SPEN
gene id: 9925:SPEN
uniprot id: A0A452G1G8
names: Similarity
messages: Belongs to the RRM Spen family.

9925:VWA9
gene id: 9925:VWA9
uniprot id: A0A452EEK7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the INTS14 family.
messages: Nucleus
messages: Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

9925:GATSL2
gene id: 9925:GATSL2
uniprot id: A0A452F890
names: Similarity
messages: Belongs to the GATS family.

9925:TMEM206
gene id: 9925:TMEM206
uniprot id: A0A452G5K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the proton-activated chloride channel family.
messages: Cell membrane
messages: Membrane

9925:HAGHL
gene id: 9925:HAGHL
uniprot id: A0A452EGI0
names: Similarity
messages: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

9925:YAE1D1
gene id: 9925:YAE1D1
uniprot id: A0A452ESZ4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:LOC102191549
gene id: 9925:LOC102191549
uniprot id: A0A452EQ34
names: Subcellular Location Annotation
messages: Membrane

9925:CARTPT
gene id: 9925:CARTPT
uniprot id: A0A452E7P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CART family.
messages: Secreted

9925:CLDN19
gene id: 9925:CLDN19
uniprot id: A0A452F236
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9925:ACTL6A
gene id: 9925:ACTL6A
uniprot id: A0A452EY84
names: Similarity
messages: Belongs to the actin family.

9925:CPSF3L
gene id: 9925:CPSF3L
uniprot id: A0A452FS82
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.
messages: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
messages: Nucleus

9925:SLBP
gene id: 9925:SLBP
uniprot id: A0A452F9F1
names: Similarity
messages: Belongs to the SLBP family.

9925:LOC100860781
gene id: 9925:LOC100860781
uniprot id: A5JST2
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9925:RMND1
gene id: 9925:RMND1
uniprot id: A0A452EHG0
names: Similarity
messages: Belongs to the RMD1/sif2 family.

9925:MAN2B1
gene id: 9925:MAN2B1
uniprot id: J7F5B7
names: Cofactor
names: Similarity
messages: Belongs to the glycosyl hydrolase 38 family.
messages: Binds 1 zinc ion per subunit.

9925:XYLT1
gene id: 9925:XYLT1
uniprot id: A0A452G8H7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycosyltransferase 14 family. XylT subfamily.
messages: Golgi apparatus membrane
messages: Membrane
messages: Monomer.

9925:LOC102179041
gene id: 9925:LOC102179041
uniprot id: A0A452E7V8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ENTPD8
gene id: 9925:ENTPD8
uniprot id: A0A452EA25
names: Similarity
messages: Belongs to the GDA1/CD39 NTPase family.

9925:CLDN15
gene id: 9925:CLDN15
uniprot id: A0A452G8Y7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the claudin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
messages: tight junction

9925:UCHL1
gene id: 9925:UCHL1
uniprot id: A0A452F853
names: Similarity
messages: Belongs to the peptidase C12 family.

9925:LOC102190566
gene id: 9925:LOC102190566
uniprot id: A0A452DR17
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:EEF1D
gene id: 9925:EEF1D
uniprot id: A0A0K0WZB8
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.

9925:GALK1
gene id: 9925:GALK1
uniprot id: A0A452DRC0
names: Similarity
messages: Belongs to the GHMP kinase family. GalK subfamily.

9925:CNOT11
gene id: 9925:CNOT11
uniprot id: A0A452G8P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT11 family.
messages: Cytoplasm
messages: Nucleus

9925:CMTM4
gene id: 9925:CMTM4
uniprot id: A0A452FKT2
names: Subcellular Location Annotation
messages: Membrane

9925:ADAMTS20
gene id: 9925:ADAMTS20
uniprot id: A0A452GAL8
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:LOC102183587
gene id: 9925:LOC102183587
uniprot id: A0A452DWN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102173489
gene id: 9925:LOC102173489
uniprot id: A0A452F7A7
names: Similarity
messages: Belongs to the DDI1 family.

9925:TXNIP
gene id: 9925:TXNIP
uniprot id: A0A452F1U3
names: Similarity
messages: Belongs to the arrestin family.

9925:LIPT2
gene id: 9925:LIPT2
uniprot id: A0A452FVQ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LipB family.
messages: Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
messages: Mitochondrion

9925:PPP1R2
gene id: 9925:PPP1R2
uniprot id: A0A452DU41
names: Similarity
messages: Belongs to the protein phosphatase inhibitor 2 family.

9925:HBM
gene id: 9925:HBM
uniprot id: A0A8C2R3G3
names: Similarity
messages: Belongs to the globin family.

9925:MAPRE2
gene id: 9925:MAPRE2
uniprot id: A0A452DKX2
uniprot id: A0A452DL06
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPRE family.
messages: cytoskeleton

9925:NCDN
gene id: 9925:NCDN
uniprot id: A0A452G7Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neurochondrin family.
messages: Postsynapse

9925:DDR1
gene id: 9925:DDR1
uniprot id: A0A452FK02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9925:LOC102190950
gene id: 9925:LOC102190950
uniprot id: A0A452DWL3
names: Similarity
messages: Belongs to the NSG family.

9925:TAF10
gene id: 9925:TAF10
uniprot id: A0A452EBR3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF10 family.
messages: Nucleus
messages: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription.

9925:ODF1
gene id: 9925:ODF1
uniprot id: I6ZM92
names: Function
messages: Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail.

9925:BASP1
gene id: 9925:BASP1
uniprot id: A0A452DTF4
names: Similarity
messages: Belongs to the BASP1 family.

9925:ALG6
gene id: 9925:ALG6
uniprot id: A0A452F7I1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ALG6/ALG8 glucosyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:P2RY1
gene id: 9925:P2RY1
uniprot id: A0A452DY13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:CDV3
gene id: 9925:CDV3
uniprot id: A0A452GBL9
names: Similarity
messages: Belongs to the CDV3 family.

9925:CACYBP
gene id: 9925:CACYBP
uniprot id: A0A452FJL5
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).
messages: Nucleus

9925:WHAMM
gene id: 9925:WHAMM
uniprot id: A0A452EN09
names: Subcellular Location Annotation
messages: Membrane

9925:TXNL4B
gene id: 9925:TXNL4B
uniprot id: A0A452DMV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DIM1 family.
messages: Nucleus
messages: Plays role in pre-mRNA splicing.

9925:CD68
gene id: 9925:CD68
uniprot id: A0A452FT55
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

9925:NOS1
gene id: 9925:NOS1
uniprot id: A0A452G3C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NOS family.
messages: dendritic spine
messages: sarcolemma

9925:PACSIN2
gene id: 9925:PACSIN2
uniprot id: A0A452E625
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PACSIN family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Early endosome
messages: Endosome membrane
messages: Membrane
messages: Recycling endosome membrane
messages: caveola
messages: cytoskeleton
messages: ruffle membrane

9925:SASS6
gene id: 9925:SASS6
uniprot id: A0A452F4Z2
names: Subcellular Location Annotation
messages: centrosome

9925:CSNK2A1
gene id: 9925:CSNK2A1
uniprot id: A0A452FP18
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:NAXE
gene id: 9925:NAXE
uniprot id: A0A452ELA0
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NnrE/AIBP family.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis.
messages: Homodimer. Interacts with APOA1 and APOA2.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mitochondrion
messages: Secreted
messages: Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation.

9925:ZDHHC5
gene id: 9925:ZDHHC5
uniprot id: A0A452EX88
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DHHC palmitoyltransferase family.
messages: Membrane
messages: The DHHC domain is required for palmitoyltransferase activity.

9925:LOC108633278
gene id: 9925:LOC108633278
uniprot id: A0A452E0A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.
messages: Nucleus

9925:ADAMTS5
gene id: 9925:ADAMTS5
uniprot id: A0A452F813
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:PSMA5
gene id: 9925:PSMA5
uniprot id: A0A452DZK5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Cytoplasm
messages: Nucleus
messages: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.

9925:ITGA5
gene id: 9925:ITGA5
uniprot id: A0A452EMC7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9925:FAM49A
gene id: 9925:FAM49A
uniprot id: A0A452F6L7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CYRI family.
messages: Interacts with RAC1 (GTP-bound form preferentially).
messages: Membrane

9925:GABARAPL1
gene id: 9925:GABARAPL1
uniprot id: A0A452G120
names: Similarity
messages: Belongs to the ATG8 family.

9925:CCL22
gene id: 9925:CCL22
uniprot id: A0A452FQ04
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9925:PPP1R3B
gene id: 9925:PPP1R3B
uniprot id: A0A452DSS5
names: Subunit
messages: Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.

9925:RAB18
gene id: 9925:RAB18
uniprot id: I1W1N3
names: Subcellular Location Annotation
messages: Apical cell membrane
messages: Cell membrane
messages: Lipid droplet

9925:LOC102172465
gene id: 9925:LOC102172465
uniprot id: A0A452F0E7
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the diacylglycerol acyltransferase family.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102176340
gene id: 9925:LOC102176340
uniprot id: A0A452EZ39
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9925:FBLN1
gene id: 9925:FBLN1
uniprot id: A0A452F2U7
uniprot id: A0A452F2Z1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the fibulin family.
messages: Homomultimerizes and interacts with various extracellular matrix components.
messages: Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:FAM214A
gene id: 9925:FAM214A
uniprot id: A0A452E3Z1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATOS family.
messages: Nucleus

9925:GTPBP10
gene id: 9925:GTPBP10
uniprot id: A0A452FA06
names: Similarity
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.

9925:TMCC3
gene id: 9925:TMCC3
uniprot id: A0A452FDD4
names: Similarity
messages: Belongs to the TEX28 family.

9925:CDK5R2
gene id: 9925:CDK5R2
uniprot id: A0A452EDF0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cyclin-dependent kinase 5 activator family.
messages: Cell membrane
messages: Heterodimer of a catalytic subunit and a regulatory subunit.
messages: Membrane

9925:BECN2
gene id: 9925:BECN2
uniprot id: A0A8C2RMV6
names: Similarity
messages: Belongs to the beclin family.

9925:PAG-11
gene id: 9925:PAG-11
uniprot id: Q9TTW5
names: Similarity
messages: Belongs to the peptidase A1 family.

9925:SLC4A9
gene id: 9925:SLC4A9
uniprot id: A0A452ET22
names: Similarity
names: Subcellular Location Annotation
messages: Basolateral cell membrane
messages: Belongs to the anion exchanger (TC 2.A.31) family.
messages: Cell membrane
messages: Lateral cell membrane
messages: Membrane

9925:GALNT1
gene id: 9925:GALNT1
uniprot id: A0A452F6U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9925:IZUMO4
gene id: 9925:IZUMO4
uniprot id: A0A8C2SFC6
names: Similarity
messages: Belongs to the Izumo family.

9925:TGFBR1
gene id: 9925:TGFBR1
uniprot id: A0A2S1UF15
uniprot id: A0A2S1YEP4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
messages: Membrane

9925:URAD
gene id: 9925:URAD
uniprot id: A0A452ESX5
names: Function
names: Similarity
messages: Belongs to the OHCU decarboxylase family.
messages: Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.

9925:LOC102177863
gene id: 9925:LOC102177863
uniprot id: A0A452DQX1
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CPNE6
gene id: 9925:CPNE6
uniprot id: A0A452G9H4
names: Similarity
messages: Belongs to the copine family.

9925:RNF114
gene id: 9925:RNF114
uniprot id: A0A452E8Q6
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling.
messages: Nucleus

9925:PAQR8
gene id: 9925:PAQR8
uniprot id: A0A452DQE7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ADIPOR family.
messages: Membrane

9925:NPTX2
gene id: 9925:NPTX2
uniprot id: A0A452ETK0
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102168959
gene id: 9925:LOC102168959
uniprot id: C6ZP52
names: Function
names: Similarity
names: Subunit
messages: Belongs to the globin family.
messages: Heterotetramer of two alpha chains and two beta chains.
messages: Involved in oxygen transport from the lung to the various peripheral tissues.

9925:KEF96 p10
gene id: 9925:KEF96_p10
uniprot id: D2KMJ8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome c oxidase subunit 2 family.
messages: Binds a copper A center.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9925:GAD2
gene id: 9925:GAD2
uniprot id: A0A452FGS2
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9925:LOC108633408
gene id: 9925:LOC108633408
uniprot id: A0A452DRQ7
names: Similarity
names: Subunit
messages: Belongs to the histone H3 family.
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:TBCE
gene id: 9925:TBCE
uniprot id: A0A452F825
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TBCE family.
messages: Cytoplasm

9925:SPPL2C
gene id: 9925:SPPL2C
uniprot id: A0A452DNA9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase A22B family.
messages: Membrane

9925:UCN3
gene id: 9925:UCN3
uniprot id: A0A452DU17
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
messages: Binds with high affinity to CRF receptors 2-alpha and 2-beta.
messages: Secreted
messages: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress.

9925:ANKS4B
gene id: 9925:ANKS4B
uniprot id: A0A452F1Z5
names: Function
messages: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

9925:FAM221B
gene id: 9925:FAM221B
uniprot id: A0A8C2PGB8
names: Similarity
messages: Belongs to the FAM221 family.

9925:HACD2
gene id: 9925:HACD2
uniprot id: A0A452FUP2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:HMGCR
gene id: 9925:HMGCR
uniprot id: A0A452ES40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HMG-CoA reductase family.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Peroxisome membrane

9925:STC2
gene id: 9925:STC2
uniprot id: A0A452DRL0
names: Similarity
names: Subunit
messages: Belongs to the stanniocalcin family.
messages: Homodimer; disulfide-linked.

9925:HDC
gene id: 9925:HDC
uniprot id: A0A452EZB3
names: Similarity
names: Subunit
messages: Belongs to the group II decarboxylase family.
messages: Homodimer.

9925:METAP1D
gene id: 9925:METAP1D
uniprot id: A0A452DRZ2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

9925:OTUD7B
gene id: 9925:OTUD7B
uniprot id: A0A452FEV4
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:LOC102187772
gene id: 9925:LOC102187772
uniprot id: A0A8C2NYE4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SLC25A23
gene id: 9925:SLC25A23
uniprot id: A0A452DVK7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane
messages: Mitochondrion inner membrane

9925:HKDC1
gene id: 9925:HKDC1
uniprot id: A0A452E4U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hexokinase family.
messages: Membrane
messages: Mitochondrion outer membrane
messages: cytosol

9925:PAFAH1B1
gene id: 9925:PAFAH1B1
uniprot id: A0A452FXL9
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LIS1/nudF family.
messages: Can self-associate. Interacts with DCX, dynein, dynactin, IQGAP1, KATNB1, NDE1, NDEL1, NUDC and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling. Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits.
messages: Dimerization mediated by the LisH domain may be required to activate dynein.
messages: Nucleus membrane
messages: Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.
messages: centrosome
messages: cytoskeleton
messages: spindle

9925:ADGRE5
gene id: 9925:ADGRE5
uniprot id: A0A452E3U2
uniprot id: A0A452E3X6
names: Caution
names: Subcellular Location Annotation
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:MEGF10
gene id: 9925:MEGF10
uniprot id: A0A452G2K5
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:PRDM5
gene id: 9925:PRDM5
uniprot id: A0A452F729
names: Subcellular Location Annotation
messages: Nucleus

9925:EIF4A1
gene id: 9925:EIF4A1
uniprot id: A0A452FLQ8
names: Domain
names: Function
names: Similarity
messages: Belongs to the DEAD box helicase family. eIF4A subfamily.
messages: RNA helicase.
messages: The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

9925:PITX3
gene id: 9925:PITX3
uniprot id: A0A452DR02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family. Bicoid subfamily.
messages: Nucleus

9925:TFIP11
gene id: 9925:TFIP11
uniprot id: A0A452EYY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TFP11/STIP family.
messages: Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.
messages: Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.
messages: Nucleus

9925:UPF2
gene id: 9925:UPF2
uniprot id: A0A452FDB7
names: Subcellular Location Annotation
messages: Cytoplasm

9925:LOC102173983
gene id: 9925:LOC102173983
uniprot id: A0A452E0V4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SRSF1
gene id: 9925:SRSF1
uniprot id: A0A452E5C9
names: Similarity
messages: Belongs to the splicing factor SR family.

9925:CUL9
gene id: 9925:CUL9
uniprot id: A0A452EKL8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cullin family.
messages: Cytoplasm

9925:LOC102178740
gene id: 9925:LOC102178740
uniprot id: A0A452EL39
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:LOC102181492
gene id: 9925:LOC102181492
uniprot id: A0A452E4B5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:USO1
gene id: 9925:USO1
uniprot id: A0A452EJ63
uniprot id: A0A452EJA2
uniprot id: A0A452EJA3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VDP/USO1/EDE1 family.
messages: Membrane

9925:WTAP
gene id: 9925:WTAP
uniprot id: A0A452G7K8
names: Similarity
messages: Belongs to the fl(2)d family.

9925:LOC102173738
gene id: 9925:LOC102173738
uniprot id: A0A452EBE1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

9925:LOC102170832
gene id: 9925:LOC102170832
uniprot id: A0A452DYU4
names: Subcellular Location Annotation
messages: mitochondrion nucleoid

9925:CKM
gene id: 9925:CKM
uniprot id: A0A452FZ73
names: Similarity
messages: Belongs to the ATP:guanido phosphotransferase family.

9925:TAC1
gene id: 9925:TAC1
uniprot id: A0A3G2SW47
uniprot id: A0A452FQV2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tachykinin family.
messages: Secreted
messages: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

9925:ELP3
gene id: 9925:ELP3
uniprot id: A0A452G4D4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

9925:PCSK7
gene id: 9925:PCSK7
uniprot id: A0A452FRA3
names: Similarity
messages: Belongs to the peptidase S8 family.

9925:RPL6
gene id: 9925:RPL6
uniprot id: A0A452EP46
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL6 family.

9925:TMEM233
gene id: 9925:TMEM233
uniprot id: A0A452DS85
names: Similarity
messages: Belongs to the CD225/Dispanin family.

9925:SORL1
gene id: 9925:SORL1
uniprot id: A0A452FGN5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS10-related sortilin family. SORL1 subfamily.
messages: Cell membrane
messages: Early endosome membrane
messages: Endoplasmic reticulum membrane
messages: Endosome membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Recycling endosome membrane
messages: Secreted
messages: multivesicular body membrane
messages: secretory vesicle membrane
messages: trans-Golgi network membrane

9925:MGAT2
gene id: 9925:MGAT2
uniprot id: A0A452E5V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 16 (GT16) protein family.
messages: Golgi apparatus membrane
messages: Membrane

9925:TOM1
gene id: 9925:TOM1
uniprot id: A0A452FWU3
uniprot id: A0A452FXK1
names: Similarity
messages: Belongs to the TOM1 family.

9925:PHOX2A
gene id: 9925:PHOX2A
uniprot id: A0A452F2B7
names: Subcellular Location Annotation
messages: Nucleus

9925:LDLRAD1
gene id: 9925:LDLRAD1
uniprot id: A0A8C2NR76
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:METTL15
gene id: 9925:METTL15
uniprot id: A0A452F3G4
names: Similarity
messages: Belongs to the methyltransferase superfamily. RsmH family.

9925:SLC9A8
gene id: 9925:SLC9A8
uniprot id: A0A452FA96
names: Similarity
messages: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.

9925:LOC102190650
gene id: 9925:LOC102190650
uniprot id: A0A452G0T6
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.

9925:ARPC1A
gene id: 9925:ARPC1A
uniprot id: A0A452EHP3
names: Function
names: Similarity
messages: Belongs to the WD repeat ARPC1 family.
messages: Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

9925:NCAN
gene id: 9925:NCAN
uniprot id: A0A452FU90
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:LOC102180576
gene id: 9925:LOC102180576
uniprot id: A0A452FRJ2
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:LOC102179469
gene id: 9925:LOC102179469
uniprot id: A0A452DW09
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:MED29
gene id: 9925:MED29
uniprot id: A0A8C2RNP8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Mediator complex subunit 29 family.
messages: Nucleus

9925:RGS9BP
gene id: 9925:RGS9BP
uniprot id: A0A452DU36
names: Similarity
messages: Belongs to the RGS7BP/RGS9BP family.

9925:LARS2
gene id: 9925:LARS2
uniprot id: A0A452DP98
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

9925:NPB
gene id: 9925:NPB
uniprot id: A0A452FHJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the neuropeptide B/W family.
messages: Secreted

9925:SENP1
gene id: 9925:SENP1
uniprot id: A0A452FIQ0
names: Similarity
messages: Belongs to the peptidase C48 family.

9925:DUPD1
gene id: 9925:DUPD1
uniprot id: A0A8C2S282
names: Similarity
messages: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

9925:KEF96 p08
gene id: 9925:KEF96_p08
uniprot id: D2KMK0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Membrane
messages: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
messages: Mitochondrion inner membrane

9925:RPS27L
gene id: 9925:RPS27L
uniprot id: A0A8C2QSY9
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

9925:TCF7L2
gene id: 9925:TCF7L2
uniprot id: A0A452E0X1
uniprot id: A0A452E141
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9925:LOC102169970
gene id: 9925:LOC102169970
uniprot id: A0A452DNT6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ERP29
gene id: 9925:ERP29
uniprot id: A0A452ECE5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Does not seem to be a disulfide isomerase.
messages: Endoplasmic reticulum lumen
messages: Homodimer.
messages: Melanosome

9925:LOC102180750
gene id: 9925:LOC102180750
uniprot id: A0A452DV13
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:EPDR1
gene id: 9925:EPDR1
uniprot id: A0A452F835
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ependymin family.
messages: Binds anionic lipids and gangliosides at acidic pH.
messages: Lysosome lumen

9925:TUBB6
gene id: 9925:TUBB6
uniprot id: A0A452G1A9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the tubulin family.
messages: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
messages: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
messages: cytoskeleton

9925:LOC108636629
gene id: 9925:LOC108636629
uniprot id: A0A452E2N8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:BTG3
gene id: 9925:BTG3
uniprot id: A0A023IYG5
names: Similarity
messages: Belongs to the BTG family.

9925:EEF1A1
gene id: 9925:EEF1A1
uniprot id: A0A452E2H7
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

9925:TMEM120B
gene id: 9925:TMEM120B
uniprot id: A0A452EMM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM120 family.
messages: Membrane
messages: Nucleus inner membrane

9925:PLA1A
gene id: 9925:PLA1A
uniprot id: A0A452EDY5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AB hydrolase superfamily. Lipase family.
messages: Secreted

9925:MMP1
gene id: 9925:MMP1
uniprot id: A0A452E3S6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9925:EPHA2
gene id: 9925:EPHA2
uniprot id: A0A452ERX4
names: Subcellular Location Annotation
messages: Membrane

9925:CITED4
gene id: 9925:CITED4
uniprot id: A0A452EJ20
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CITED family.
messages: Nucleus

9925:PRKCZ
gene id: 9925:PRKCZ
uniprot id: A0A452E688
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
messages: Cytoplasm

9925:TM2D2
gene id: 9925:TM2D2
uniprot id: A0A452FMJ6
names: Subcellular Location Annotation
messages: Membrane

9925:KCNG2
gene id: 9925:KCNG2
uniprot id: A0A452E9X6
names: Subcellular Location Annotation
messages: Membrane

9925:MAP2K5
gene id: 9925:MAP2K5
uniprot id: A0A452FL00
uniprot id: A0A8C2NVM1
names: Similarity
messages: Belongs to the protein kinase superfamily.

9925:LOC102181522
gene id: 9925:LOC102181522
uniprot id: A0A452E0E9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:GAST
gene id: 9925:GAST
uniprot id: A0A452ECX6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gastrin/cholecystokinin family.
messages: Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
messages: Secreted

9925:LOC102168236
gene id: 9925:LOC102168236
uniprot id: A0A452FAD8
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.

9925:TDP1
gene id: 9925:TDP1
uniprot id: A0A452ECF8
uniprot id: A0A452ECR8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tyrosyl-DNA phosphodiesterase family.
messages: Nucleus

9925:LOC102180153
gene id: 9925:LOC102180153
uniprot id: A0A452DN89
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM45 family.
messages: Membrane

9925:KDELR1
gene id: 9925:KDELR1
uniprot id: A0A452FJ43
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERD2 family.
messages: COPI-coated vesicle membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:MARK1
gene id: 9925:MARK1
uniprot id: A0A452F5X9
uniprot id: A0A452F6G8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
messages: dendrite

9925:ATP5D
gene id: 9925:ATP5D
uniprot id: A0A452GB32
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase epsilon chain family.
messages: Mitochondrion inner membrane

9925:RIMKLA
gene id: 9925:RIMKLA
uniprot id: A0A452EQ69
names: Similarity
messages: Belongs to the RimK family.

9925:NSMCE1
gene id: 9925:NSMCE1
uniprot id: A0A452FBG3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NSE1 family.
messages: Component of the Smc5-Smc6 complex.
messages: Nucleus
messages: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.
messages: telomere

9925:GPR37L1
gene id: 9925:GPR37L1
uniprot id: A0A452E487
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:ADRA1D
gene id: 9925:ADRA1D
uniprot id: A0A452DLY9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.
messages: Membrane
messages: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

9925:EXTL1
gene id: 9925:EXTL1
uniprot id: A0A452EEH7
uniprot id: A0A452EEQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 47 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:BICC1
gene id: 9925:BICC1
uniprot id: A0A452E118
names: Similarity
messages: Belongs to the BicC family.

9925:CILP
gene id: 9925:CILP
uniprot id: A0A452EDB6
uniprot id: A0A452EDJ1
names: Subcellular Location Annotation
messages: extracellular matrix

9925:NDUFA7
gene id: 9925:NDUFA7
uniprot id: A0A8C2PBE4
names: Function
names: Similarity
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFA7 subunit family.
messages: Complex I is composed of 45 different subunits.

9925:KARS
gene id: 9925:KARS
uniprot id: A0A452EJX4
uniprot id: A0A452EKC9
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9925:ABL1
gene id: 9925:ABL1
uniprot id: A0A452FJM7
uniprot id: A0A452FKI1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9925:TMEM263
gene id: 9925:TMEM263
uniprot id: A0A452ERR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM263 family.
messages: Membrane

9925:TMEM63A
gene id: 9925:TMEM63A
uniprot id: A0A665AV17
uniprot id: W6AWL7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CSC1 (TC 1.A.17) family.
messages: Membrane

9925:OSBPL5
gene id: 9925:OSBPL5
uniprot id: A0A452FXG3
names: Similarity
messages: Belongs to the OSBP family.

9925:VPS37B
gene id: 9925:VPS37B
uniprot id: A0A452F130
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the VPS37 family.
messages: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
messages: Endosome membrane
messages: Late endosome membrane

9925:CPLX3
gene id: 9925:CPLX3
uniprot id: A0A452DLN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complexin/synaphin family.
messages: Synapse

9925:KRT82
gene id: 9925:KRT82
uniprot id: A0A452GAM5
names: Similarity
messages: Belongs to the intermediate filament family.

9925:FAM193B
gene id: 9925:FAM193B
uniprot id: A0A452FX81
uniprot id: A0A452FXX9
names: Similarity
messages: Belongs to the FAM193 family.

9925:BCAN
gene id: 9925:BCAN
uniprot id: A0A452E992
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aggrecan/versican proteoglycan family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:ORAI3
gene id: 9925:ORAI3
uniprot id: A0A452EMD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

9925:DCAF10
gene id: 9925:DCAF10
uniprot id: A0A452E3I5
names: Function
names: Similarity
messages: Belongs to the WD repeat DCAF10 family.
messages: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

9925:LOC102191560
gene id: 9925:LOC102191560
uniprot id: A0A452E0K9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adaptor complexes small subunit family.
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

9925:COQ10A
gene id: 9925:COQ10A
uniprot id: A0A452EM10
names: Function
names: Similarity
names: Subunit
messages: Belongs to the COQ10 family.
messages: Interacts with coenzyme Q.
messages: Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.

9925:CHST12
gene id: 9925:CHST12
uniprot id: A0A452DRR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfotransferase 2 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:CDH22
gene id: 9925:CDH22
uniprot id: A0A452F743
names: Function
names: Subcellular Location Annotation
messages: Cadherins are calcium-dependent cell adhesion proteins.
messages: Cell membrane
messages: Membrane

9925:DMGDH
gene id: 9925:DMGDH
uniprot id: A0A452FL57
names: Similarity
messages: Belongs to the GcvT family.

9925:PROK2
gene id: 9925:PROK2
uniprot id: A0A1S6PXH4
uniprot id: A0A452FGH7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AVIT (prokineticin) family.
messages: Secreted

9925:DIS3L
gene id: 9925:DIS3L
uniprot id: A0A452E192
names: Similarity
messages: Belongs to the RNR ribonuclease family.

9925:NUP88
gene id: 9925:NUP88
uniprot id: A0A8C2S5J8
names: Subcellular Location Annotation
messages: nuclear pore complex

9925:CIAO1
gene id: 9925:CIAO1
uniprot id: A0A452FMH1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the WD repeat CIA1 family.
messages: Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.
messages: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.

9925:ITGAL
gene id: 9925:ITGAL
uniprot id: Q32Y13
uniprot id: Q32Y14
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9925:MRM1
gene id: 9925:MRM1
uniprot id: A0A452DXF3
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

9925:GPR141
gene id: 9925:GPR141
uniprot id: A0A452E5H5
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:CNOT9
gene id: 9925:CNOT9
uniprot id: A0A452G6W7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CNOT9 family.
messages: P-body

9925:PPP1R7
gene id: 9925:PPP1R7
uniprot id: A0A452EBZ9
names: Similarity
messages: Belongs to the SDS22 family.

9925:LOC102184552
gene id: 9925:LOC102184552
uniprot id: A0A452E365
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TMEM55B
gene id: 9925:TMEM55B
uniprot id: A0A452EJM0
names: Function
names: Subcellular Location Annotation
messages: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane
messages: Membrane
messages: phagosome membrane

9925:TSNAX
gene id: 9925:TSNAX
uniprot id: A0A452EAM4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the translin family.
messages: Nucleus

9925:NIT1
gene id: 9925:NIT1
uniprot id: A0A452DTV3
names: Similarity
messages: Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.

9925:GPR68
gene id: 9925:GPR68
uniprot id: A0A452E1K6
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:TCF7
gene id: 9925:TCF7
uniprot id: A0A452GAV5
uniprot id: A0A452GBC2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TCF/LEF family.
messages: Nucleus

9925:CA11
gene id: 9925:CA11
uniprot id: A0A452FTK2
names: Function
names: Similarity
messages: Belongs to the alpha-carbonic anhydrase family.
messages: Does not have a catalytic activity.

9925:IMPDH2
gene id: 9925:IMPDH2
uniprot id: A0A452E7M2
uniprot id: A0A8C2SJ22
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.
messages: Nucleus

9925:ASAH1
gene id: 9925:ASAH1
uniprot id: A0A452E0H9
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acid ceramidase family.
messages: Heterodimer.
messages: Lysosome

9925:CCL28
gene id: 9925:CCL28
uniprot id: A0A8C2XUB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9925:NDUFAB1
gene id: 9925:NDUFAB1
uniprot id: A0A452E7C6
names: Function
names: Similarity
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.

9925:DNASE1
gene id: 9925:DNASE1
uniprot id: A0A452F6X0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNase I family.
messages: Nucleus envelope
messages: Zymogen granule

9925:GGA2
gene id: 9925:GGA2
uniprot id: A0A452EZJ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGA protein family.
messages: Early endosome membrane
messages: Endosome membrane
messages: Membrane
messages: trans-Golgi network membrane

9925:RAD21
gene id: 9925:RAD21
uniprot id: A0A452E4Q2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the rad21 family.
messages: Nucleus

9925:TSPAN12
gene id: 9925:TSPAN12
uniprot id: A0A452EDP9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9925:FAM8A1
gene id: 9925:FAM8A1
uniprot id: A0A452E2H0
names: Subcellular Location Annotation
messages: Membrane

9925:SPON1
gene id: 9925:SPON1
uniprot id: A0A452FYE2
names: Subcellular Location Annotation
messages: extracellular matrix

9925:LMNB2
gene id: 9925:LMNB2
uniprot id: A0A452EGA4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intermediate filament family.
messages: Nucleus lamina

9925:ZEB2
gene id: 9925:ZEB2
uniprot id: A0A452FGS1
names: Similarity
messages: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.

9925:EGFL7
gene id: 9925:EGFL7
uniprot id: A0A8C2SB73
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:LOC102168979
gene id: 9925:LOC102168979
uniprot id: A0A452FTY4
names: Function
names: Similarity
messages: Belongs to the SAA family.
messages: Major acute phase reactant. Apolipoprotein of the HDL complex.

9925:E2F5
gene id: 9925:E2F5
uniprot id: A0A452EDR6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the E2F/DP family.
messages: Nucleus

9925:FMO4
gene id: 9925:FMO4
uniprot id: A0A452FY71
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FMO family.
messages: Endoplasmic reticulum membrane

9925:AQP3
gene id: 9925:AQP3
uniprot id: A0A6C0WYK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MIP/aquaporin (TC 1.A.8) family.
messages: Cell membrane
messages: Membrane

9925:ZNF18
gene id: 9925:ZNF18
uniprot id: A0A452EAE7
names: Subcellular Location Annotation
messages: Nucleus

9925:SCRN3
gene id: 9925:SCRN3
uniprot id: A0A452E463
names: Similarity
messages: Belongs to the peptidase C69 family. Secernin subfamily.

9925:TRABD2B
gene id: 9925:TRABD2B
uniprot id: A0A452EV31
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TIKI family.
messages: Cell membrane
messages: Divalent metal cations. Mn(2+) or Co(2+).
messages: Membrane
messages: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation.

9925:LOC102177976
gene id: 9925:LOC102177976
uniprot id: A0A452DWD7
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:IL6
gene id: 9925:IL6
uniprot id: E3UT57
uniprot id: Q28319
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an essential factor in bone homeostasis and on vessels directly or indirectly by induction of VEGF, resulting in increased angiogenesis activity and vascular permeability. Induces, through 'trans-signaling' and synergistically with IL1B and TNF, the production of VEGF. Involved in metabolic controls, is discharged into the bloodstream after muscle contraction increasing lipolysis and improving insulin resistance (By similarity). 'Trans-signaling' in central nervous system also regulates energy and glucose homeostasis. Mediates, through GLP-1, crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand (By similarity). Also acts as a myokine (By similarity). Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). Also has a pivotal role in iron metabolism by regulating HAMP/hepcidin expression upon inflammation or bacterial infection (By similarity). Through activation of IL6ST-YAP-NOTCH pathway, induces inflammation-induced epithelial regeneration (By similarity).
messages: Belongs to the IL-6 superfamily.
messages: Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST. Interacts with IL6R (via the N-terminal ectodomain); this interaction may be affected by IL6R-binding with SORL1, hence decreasing IL6 cis signaling. Interacts with SORL1 (via the N-terminal ectodomain); this interaction leads to IL6 internalization and lysosomal degradation. May form a trimeric complex with the soluble SORL1 ectodomain and soluble IL6R receptor; this interaction might stabilize circulating IL6, hence promoting IL6 trans signaling.
messages: Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.
messages: IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (By similarity). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells (By similarity).
messages: IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology. In the innate immune response, is synthesized by myeloid cells, such as macrophages and dendritic cells, upon recognition of pathogens through toll-like receptors (TLRs) at the site of infection or tissue injury (By similarity). In the adaptive immune response, is required for the differentiation of B cells into immunoglobulin-secreting cells. Plays a major role in the differentiation of CD4(+) T cell subsets. Essential factor for the development of T follicular helper (Tfh) cells that are required for the induction of germinal-center formation. Required to drive naive CD4(+) T cells to the Th17 lineage. Also required for proliferation of myeloma cells and the survival of plasmablast cells.
messages: Secreted

9925:COPS6
gene id: 9925:COPS6
uniprot id: A0A8C2S956
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M67A family. CSN6 subfamily.
messages: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.
messages: Cytoplasm
messages: Nucleus

9925:THPO
gene id: 9925:THPO
uniprot id: A0A452F1T3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPO/TPO family.
messages: Secreted

9925:NAB1
gene id: 9925:NAB1
uniprot id: A0A452FLP7
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NAB family.
messages: Homomultimers may associate with EGR1 bound to DNA.
messages: Nucleus

9925:LAMP3
gene id: 9925:LAMP3
uniprot id: A0A452EAF9
uniprot id: A0A452EAX1
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMP family.
messages: Endosome membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Lysosome membrane
messages: Membrane

9925:FAM174A
gene id: 9925:FAM174A
uniprot id: A0A452F8X2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FAM174 family.
messages: Membrane

9925:LCN9
gene id: 9925:LCN9
uniprot id: A0A452G5A7
names: Similarity
messages: Belongs to the calycin superfamily. Lipocalin family.

9925:TP53BP2
gene id: 9925:TP53BP2
uniprot id: A0A452G265
names: Subcellular Location Annotation
messages: Nucleus

9925:IL4
gene id: 9925:IL4
uniprot id: P79155
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the IL-4/IL-13 family.
messages: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4.
messages: Secreted

9925:STRADB
gene id: 9925:STRADB
uniprot id: A0A452ERI1
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
messages: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation.

9925:PHTF2
gene id: 9925:PHTF2
uniprot id: A0A452EIV9
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102182458
gene id: 9925:LOC102182458
uniprot id: A0A452DY82
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:LOC102188506
gene id: 9925:LOC102188506
uniprot id: A0A452F8T9
names: Subcellular Location Annotation
messages: Membrane

9925:PUS3
gene id: 9925:PUS3
uniprot id: A0A452EBI4
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.

9925:NKX6-3
gene id: 9925:NKX6-3
uniprot id: A0A452DPJ9
names: Subcellular Location Annotation
messages: Nucleus

9925:B3GALT2
gene id: 9925:B3GALT2
uniprot id: A0A452DR82
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 31 family.
messages: Golgi apparatus membrane
messages: Membrane

9925:UBE2I
gene id: 9925:UBE2I
uniprot id: A0A452F1N3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9925:MS4A10
gene id: 9925:MS4A10
uniprot id: A0A452DZL5
names: Similarity
messages: Belongs to the MS4A family.

9925:ALOX5AP
gene id: 9925:ALOX5AP
uniprot id: A0A452FE40
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAPEG family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:SLC52A2
gene id: 9925:SLC52A2
uniprot id: A0A452EML4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the riboflavin transporter family.
messages: Cell membrane
messages: Membrane
messages: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.

9925:PIAS1
gene id: 9925:PIAS1
uniprot id: A0A452EJT2
names: Similarity
messages: Belongs to the PIAS family.

9925:KPNA5
gene id: 9925:KPNA5
uniprot id: A0A452G264
names: Function
names: Similarity
messages: Belongs to the importin alpha family.
messages: Functions in nuclear protein import.

9925:CRYBA1
gene id: 9925:CRYBA1
uniprot id: A0A452EHV1
names: Function
names: Similarity
messages: Belongs to the beta/gamma-crystallin family.
messages: Crystallins are the dominant structural components of the vertebrate eye lens.

9925:SULT1C2
gene id: 9925:SULT1C2
uniprot id: A0A452FGS8
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9925:C10H14orf166
gene id: 9925:C10H14orf166
uniprot id: A0A452F5I1
names: Similarity
messages: Belongs to the RTRAF family.

9925:B4GALT1
gene id: 9925:B4GALT1
uniprot id: E9NRZ3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 7 family.
messages: Golgi apparatus membrane
messages: Membrane
messages: Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.

9925:BCAR1
gene id: 9925:BCAR1
uniprot id: A0A452G738
uniprot id: A0A452G743
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CAS family.
messages: focal adhesion

9925:DNA2
gene id: 9925:DNA2
uniprot id: A0A452F7L2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.
messages: Mitochondrion
messages: Nucleus

9925:SOGA3
gene id: 9925:SOGA3
uniprot id: A0A452DS97
names: Similarity
messages: Belongs to the SOGA family.

9925:LOC102172282
gene id: 9925:LOC102172282
uniprot id: A0A452E361
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:GALNT16
gene id: 9925:GALNT16
uniprot id: A0A452FYX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9925:SRPRA
gene id: 9925:SRPRA
uniprot id: A0A452EC92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:LOC102176060
gene id: 9925:LOC102176060
uniprot id: A0A452ECN8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ORMDL3
gene id: 9925:ORMDL3
uniprot id: A0A452G8N4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ORM family.
messages: Membrane
messages: Negative regulator of sphingolipid synthesis.

9925:KLC2
gene id: 9925:KLC2
uniprot id: A0A452ER77
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the kinesin light chain family.
messages: Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.
messages: Oligomeric complex composed of two heavy chains and two light chains.
messages: cytoskeleton

9925:RDH8
gene id: 9925:RDH8
uniprot id: A0A452FDJ7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Membrane
messages: Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity.

9925:DYNLL1
gene id: 9925:DYNLL1
uniprot id: A0A452F8J5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dynein light chain family.
messages: cytoskeleton

9925:PARP9
gene id: 9925:PARP9
uniprot id: A0A452ETJ6
names: Similarity
messages: Belongs to the ARTD/PARP family.

9925:ERBIN
gene id: 9925:ERBIN
uniprot id: A0A452EL59
uniprot id: A0A452EL85
uniprot id: A0A452ELI9
uniprot id: A0A452ELY3
names: Similarity
messages: Belongs to the LAP (LRR and PDZ) protein family.

9925:PCNX1
gene id: 9925:PCNX1
uniprot id: A0A452G791
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9925:UCP1
gene id: 9925:UCP1
uniprot id: A0A452E6H7
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: May undergo ubiquitin-mediated proteasomal degradation.
messages: Membrane
messages: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.
messages: Mitochondrion inner membrane

9925:CSNK1G2
gene id: 9925:CSNK1G2
uniprot id: A0A452EAX9
names: Similarity
messages: Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

9925:LOC102175526
gene id: 9925:LOC102175526
uniprot id: A0A452G5C0
names: Function
names: Similarity
messages: Belongs to the phospholipid scramblase family.
messages: May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.

9925:NUMB
gene id: 9925:NUMB
uniprot id: A0A452F030
uniprot id: A0A452F060
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Plays a role in the process of neurogenesis.

9925:POU4F2
gene id: 9925:POU4F2
uniprot id: A0A452EC03
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the POU transcription factor family.
messages: Nucleus

9925:HOXA10
gene id: 9925:HOXA10
uniprot id: A0A452EMU6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9925:PXMP2
gene id: 9925:PXMP2
uniprot id: A0A452G001
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peroxisomal membrane protein PXMP2/4 family.
messages: Membrane

9925:DTX3
gene id: 9925:DTX3
uniprot id: A0A8C2RIB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Deltex family.
messages: Cytoplasm

9925:DPYSL4
gene id: 9925:DPYSL4
uniprot id: A0A452DKV2
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9925:GLIS2
gene id: 9925:GLIS2
uniprot id: A0A452FMS6
names: Similarity
messages: Belongs to the GLI C2H2-type zinc-finger protein family.

9925:TFAP2A
gene id: 9925:TFAP2A
uniprot id: A0A452F4L7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AP-2 family.
messages: Nucleus

9925:LOC102179637
gene id: 9925:LOC102179637
uniprot id: A0A452G721
names: Similarity
messages: Belongs to the peptidase A1 family.

9925:TLR6
gene id: 9925:TLR6
uniprot id: F1CGU3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9925:CAPN10
gene id: 9925:CAPN10
uniprot id: A0A452EWS5
names: Similarity
messages: Belongs to the peptidase C2 family.

9925:ENDOG
gene id: 9925:ENDOG
uniprot id: A0A452FG10
names: Similarity
messages: Belongs to the DNA/RNA non-specific endonuclease family.

9925:GNS
gene id: 9925:GNS
uniprot id: P50426
names: Cofactor
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Lysosome
messages: Processed by internal peptidase.
messages: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

9925:BCL9L
gene id: 9925:BCL9L
uniprot id: A0A452DQM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BCL9 family.
messages: Nucleus

9925:TLX3
gene id: 9925:TLX3
uniprot id: A0A452DZ08
names: Subcellular Location Annotation
messages: Nucleus

9925:RET
gene id: 9925:RET
uniprot id: A0A452FIX0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane
messages: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.

9925:PLCD1
gene id: 9925:PLCD1
uniprot id: A0A452ECQ4
names: Cofactor
messages: Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain.

9925:TACR2
gene id: 9925:TACR2
uniprot id: A0A452FLN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:NEUROD6
gene id: 9925:NEUROD6
uniprot id: A0A452E677
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102186672
gene id: 9925:LOC102186672
uniprot id: A0A452DMM8
uniprot id: A0A452DMN1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S1 family.
messages: Membrane

9925:FAM20C
gene id: 9925:FAM20C
uniprot id: A0A452G0J9
names: Similarity
messages: Belongs to the FAM20 family.

9925:MARCKS
gene id: 9925:MARCKS
uniprot id: A0A452E037
names: Similarity
messages: Belongs to the MARCKS family.

9925:HAUS3
gene id: 9925:HAUS3
uniprot id: A0A452EJP3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAUS3 family.
messages: spindle

9925:LDLRAD3
gene id: 9925:LDLRAD3
uniprot id: A0A452FSA4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:FAH
gene id: 9925:FAH
uniprot id: A0A452EEE5
names: Similarity
messages: Belongs to the FAH family.

9925:RPL5
gene id: 9925:RPL5
uniprot id: A0A452EQ37
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Cytoplasm

9925:CASP14
gene id: 9925:CASP14
uniprot id: A0A452F7T4
names: Similarity
messages: Belongs to the peptidase C14A family.

9925:GPR65
gene id: 9925:GPR65
uniprot id: A0A8C2NIC8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:LCOR
gene id: 9925:LCOR
uniprot id: A0A452DYB7
names: Subcellular Location Annotation
messages: Nucleus

9925:LIN52
gene id: 9925:LIN52
uniprot id: A0A452FX76
names: Similarity
messages: Belongs to the lin-52 family.

9925:IL7
gene id: 9925:IL7
uniprot id: A0A452EFQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IL-7/IL-9 family.
messages: Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis.
messages: Interacts with IL7R and CSF2RG.
messages: Secreted

9925:SLC15A4
gene id: 9925:SLC15A4
uniprot id: A0A452FEK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
messages: Membrane

9925:GPR171
gene id: 9925:GPR171
uniprot id: A0A452DX34
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:HAMP
gene id: 9925:HAMP
uniprot id: A0A452G6H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hepcidin family.
messages: Secreted

9925:ANO3
gene id: 9925:ANO3
uniprot id: A0A452FGZ2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anoctamin family.
messages: Cell membrane
messages: Membrane

9925:GSPT1
gene id: 9925:GSPT1
uniprot id: A0A452DZN0
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

9925:MTCH2
gene id: 9925:MTCH2
uniprot id: A0A452EDM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrial carrier (TC 2.A.29) family.
messages: Membrane

9925:LOC102188887
gene id: 9925:LOC102188887
uniprot id: A0A452EWF2
names: Similarity
messages: Belongs to the type-B carboxylesterase/lipase family.

9925:LOC102174380
gene id: 9925:LOC102174380
uniprot id: A0A452FNS8
names: Similarity
messages: Belongs to the glycosyl hydrolase 35 family.

9925:TXLNB
gene id: 9925:TXLNB
uniprot id: A0A452G9A6
names: Similarity
messages: Belongs to the taxilin family.

9925:BANP
gene id: 9925:BANP
uniprot id: A0A8C2RPT3
names: Similarity
messages: Belongs to the BANP/SMAR1 family.

9925:CPD
gene id: 9925:CPD
uniprot id: A0A452ETV6
names: Similarity
messages: Belongs to the peptidase M14 family.

9925:KDM3B
gene id: 9925:KDM3B
uniprot id: A0A452G3P0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM2 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
messages: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
messages: Nucleus
messages: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.

9925:PPP4R3A
gene id: 9925:PPP4R3A
uniprot id: A0A452E340
names: Similarity
messages: Belongs to the SMEK family.

9925:LONP1
gene id: 9925:LONP1
uniprot id: A0A452DPV7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters.
messages: Belongs to the peptidase S16 family.
messages: Homohexamer. Organized in a ring with a central cavity. The ATP-binding and proteolytic domains (AP-domain) form a hexameric chamber, while the N-terminal domain is arranged as a trimer of dimers. DNA and RNA binding is stimulated by substrate and inhibited by ATP binding. Interacts with TWNK and mitochondrial DNA polymerase subunit POLG.
messages: Mitochondrion matrix

9925:SKA3
gene id: 9925:SKA3
uniprot id: A0A452F0W9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SKA3 family.
messages: kinetochore
messages: spindle

9925:FAM168B
gene id: 9925:FAM168B
uniprot id: A0A452FVI3
names: Similarity
messages: Belongs to the FAM168 family.

9925:EIF3E
gene id: 9925:EIF3E
uniprot id: A0A452DRD5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit E family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
messages: Cytoplasm
messages: Nucleus
messages: PML body
messages: Phosphorylated upon DNA damage, probably by ATM or ATR.

9925:LOC108636429
gene id: 9925:LOC108636429
uniprot id: A0A452E016
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CNFN
gene id: 9925:CNFN
uniprot id: A0A452ELR1
names: Similarity
messages: Belongs to the cornifelin family.

9925:LOC108636544
gene id: 9925:LOC108636544
uniprot id: A0A452DW99
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.
messages: Secreted

9925:FLCN
gene id: 9925:FLCN
uniprot id: A0A452GB67
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the folliculin family.
messages: Lysosome membrane
messages: Membrane
messages: Nucleus
messages: centrosome
messages: cilium
messages: cytosol
messages: spindle

9925:STMN1
gene id: 9925:STMN1
uniprot id: A0A452FTR2
names: Similarity
messages: Belongs to the stathmin family.

9925:CARMIL3
gene id: 9925:CARMIL3
uniprot id: A0A452DXZ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CARMIL family.
messages: Cytoplasm

9925:EGR3
gene id: 9925:EGR3
uniprot id: A0A452FPV1
uniprot id: A0A452FPX1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EGR C2H2-type zinc-finger protein family.
messages: Nucleus

9925:ADRA1B
gene id: 9925:ADRA1B
uniprot id: A0A452F3S8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Cytoplasm
messages: Membrane
messages: Nucleus membrane
messages: This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
messages: caveola

9925:DOT1L
gene id: 9925:DOT1L
uniprot id: A0A452ERM4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.
messages: Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.
messages: Histone methyltransferase. Methylates 'Lys-79' of histone H3.
messages: In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.
messages: Nucleus

9925:IDO1
gene id: 9925:IDO1
uniprot id: W5U964
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

9925:GALNT12
gene id: 9925:GALNT12
uniprot id: A0A452EEI9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
messages: Golgi apparatus membrane
messages: Membrane

9925:EPHB1
gene id: 9925:EPHB1
uniprot id: A0A452F900
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: dendrite

9925:EPHX1
gene id: 9925:EPHX1
uniprot id: A0A452F2I2
uniprot id: F2X2Y8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S33 family.
messages: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9925:SEPT2
gene id: 9925:SEPT2
uniprot id: A0A452G8J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.
messages: Cleavage furrow
messages: Filament-forming cytoskeletal GTPase.
messages: Midbody
messages: Septins polymerize into heterooligomeric protein complexes that form filaments.
messages: cilium membrane
messages: flagellum
messages: spindle

9925:PARVA
gene id: 9925:PARVA
uniprot id: A0A452G0P9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the parvin family.
messages: Cell membrane

9925:PGPEP1
gene id: 9925:PGPEP1
uniprot id: A0A452G7R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C15 family.
messages: Cytoplasm
messages: Removes 5-oxoproline from various penultimate amino acid residues except L-proline.

9925:UPF1
gene id: 9925:UPF1
uniprot id: A0A452E6L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA2/NAM7 helicase family.
messages: Cytoplasm

9925:HACD1
gene id: 9925:HACD1
uniprot id: A0A452G630
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:RNF31
gene id: 9925:RNF31
uniprot id: A0A452G9V5
names: Similarity
messages: Belongs to the RBR family.

9925:MLST8
gene id: 9925:MLST8
uniprot id: A0A452DRC5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the WD repeat LST8 family.
messages: Cytoplasm
messages: Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.
messages: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA.

9925:TMEM208
gene id: 9925:TMEM208
uniprot id: A0A8C2XRS1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM208 family.
messages: Endoplasmic reticulum membrane
messages: May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.
messages: Membrane

9925:LOC102181061
gene id: 9925:LOC102181061
uniprot id: A0A452DWQ7
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ADAMTS12
gene id: 9925:ADAMTS12
uniprot id: A0A452FEI8
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:MRPS18B
gene id: 9925:MRPS18B
uniprot id: A0A452FKR4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
messages: Mitochondrion

9925:DGKZ
gene id: 9925:DGKZ
uniprot id: A0A452F363
uniprot id: A0A452F399
uniprot id: A0A452F3N1
names: Similarity
messages: Belongs to the eukaryotic diacylglycerol kinase family.

9925:MAP3K11
gene id: 9925:MAP3K11
uniprot id: A0A452E300
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

9925:KCNA6
gene id: 9925:KCNA6
uniprot id: A0A452DWQ4
names: Subcellular Location Annotation
messages: Membrane

9925:MDH1
gene id: 9925:MDH1
uniprot id: A0A452EQW7
names: Similarity
names: Subunit
messages: Belongs to the LDH/MDH superfamily. MDH type 2 family.
messages: Homodimer.

9925:LOC102184291
gene id: 9925:LOC102184291
uniprot id: A0A452E9E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TTC30/dfy-1/fleer family.
messages: Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.
messages: cilium

9925:NUCB1
gene id: 9925:NUCB1
uniprot id: A0A8C2R841
names: Similarity
messages: Belongs to the nucleobindin family.

9925:LOC102178870
gene id: 9925:LOC102178870
uniprot id: A0A452DW09
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:ATP6V1E1
gene id: 9925:ATP6V1E1
uniprot id: A0A452FQM7
names: Similarity
messages: Belongs to the V-ATPase E subunit family.

9925:EYA4
gene id: 9925:EYA4
uniprot id: A0A452FL61
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HAD-like hydrolase superfamily. EYA family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Nucleus

9925:NLK
gene id: 9925:NLK
uniprot id: A0A452FQA0
names: Activity Regulation
names: Similarity
messages: Activated by threonine and tyrosine phosphorylation.
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.

9925:FAM149B1
gene id: 9925:FAM149B1
uniprot id: A0A8C2PFW4
names: Similarity
messages: Belongs to the FAM149 family.

9925:HSPD1
gene id: 9925:HSPD1
uniprot id: A0A452DQM6
names: Similarity
messages: Belongs to the chaperonin (HSP60) family.

9925:PPP1R12C
gene id: 9925:PPP1R12C
uniprot id: A0A452F158
names: Subcellular Location Annotation
names: Subunit
messages: PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.
messages: stress fiber

9925:TCTEX1D4
gene id: 9925:TCTEX1D4
uniprot id: A0A452E072
names: Similarity
messages: Belongs to the dynein light chain Tctex-type family.

9925:GTF2I
gene id: 9925:GTF2I
uniprot id: A0A452DX80
uniprot id: A0A452DXC3
uniprot id: A0A452DXG8
names: Subcellular Location Annotation
messages: Nucleus

9925:TMEM94
gene id: 9925:TMEM94
uniprot id: A0A452EIL6
names: Subcellular Location Annotation
messages: Membrane

9925:KRT40
gene id: 9925:KRT40
uniprot id: A0A452FZW3
names: Similarity
messages: Belongs to the intermediate filament family.

9925:TLR2
gene id: 9925:TLR2
uniprot id: Q0GC71
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Toll-like receptor family.
messages: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (By similarity).
messages: Ester-bound lipid substrates are bound through a crevice formed between the LRR 11 and LRR 12.
messages: Glycosylation of Asn-442 is critical for secretion of the N-terminal ectodomain of TLR2.
messages: In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.
messages: Interacts with LY96, TLR1 and TLR6 (via extracellular domain). TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36. Binds MYD88 (via TIR domain). Interacts with TICAM1. Interacts with CNPY3. Interacts with ATG16L1. Interacts with PPP1R11. Interacts with TICAM2. Interacts with TIRAP (By similarity).
messages: Membrane
messages: Membrane raft
messages: The ATG16L1-binding motif mediates interaction with ATG16L1.
messages: Ubiquitinated at Lys-754 by PPP1R11, leading to its degradation. Deubiquitinated by USP2.
messages: phagosome membrane

9925:BPIFC
gene id: 9925:BPIFC
uniprot id: A0A452FI56
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

9925:FGR
gene id: 9925:FGR
uniprot id: A0A452ER48
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family.
messages: Cell membrane

9925:SERPINE3
gene id: 9925:SERPINE3
uniprot id: A0A452EL19
names: Similarity
messages: Belongs to the serpin family.

9925:TMEM43
gene id: 9925:TMEM43
uniprot id: A0A452FFF7
uniprot id: A0A452FG13
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM43 family.
messages: Membrane

9925:EPS8L2
gene id: 9925:EPS8L2
uniprot id: A0A452EU61
names: Similarity
messages: Belongs to the EPS8 family.

9925:USP39
gene id: 9925:USP39
uniprot id: A0A452FH76
names: Subcellular Location Annotation
messages: Nucleus

9925:MYO1D
gene id: 9925:MYO1D
uniprot id: A0A452EPI6
names: Similarity
messages: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

9925:CLIC1
gene id: 9925:CLIC1
uniprot id: A0A452FXD6
names: Domain
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chloride channel CLIC family.
messages: Cell membrane
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
messages: Membrane
messages: Nucleus membrane

9925:RBM46
gene id: 9925:RBM46
uniprot id: A0A452DLT8
names: Subcellular Location Annotation
messages: Cytoplasm

9925:SLCO1A2
gene id: 9925:SLCO1A2
uniprot id: A0A452F3I5
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:SERP1
gene id: 9925:SERP1
uniprot id: W6CGL7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RAMP4 family.
messages: Endoplasmic reticulum membrane
messages: May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.
messages: Membrane

9925:MANBAL
gene id: 9925:MANBAL
uniprot id: A0A452FX90
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0239 family.
messages: Membrane

9925:ACLY
gene id: 9925:ACLY
uniprot id: A0A452FSH4
uniprot id: A0A452FSK9
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.
messages: In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.

9925:ABCB8
gene id: 9925:ABCB8
uniprot id: A0A452FTM6
names: Subcellular Location Annotation
messages: Membrane

9925:EPHA8
gene id: 9925:EPHA8
uniprot id: A0A452FTC4
names: Subcellular Location Annotation
messages: Membrane

9925:PFDN2
gene id: 9925:PFDN2
uniprot id: A0A452FKK3
names: Function
names: Similarity
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.

9925:ISCU
gene id: 9925:ISCU
uniprot id: A0A452FB22
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form. May modulate NFS1 desulfurase activity in a zinc-dependent manner. Modulates the interaction between FXN and the cysteine desulfurase complex.

9925:RAB39A
gene id: 9925:RAB39A
uniprot id: A0A452FBJ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Rab family.
messages: Cell membrane
messages: Membrane

9925:PHC3
gene id: 9925:PHC3
uniprot id: A0A452EJB2
uniprot id: A0A452EJJ2
uniprot id: A0A452EJM2
names: Subcellular Location Annotation
messages: Nucleus

9925:WAPL
gene id: 9925:WAPL
uniprot id: A0A452EI00
names: Similarity
messages: Belongs to the WAPL family.

9925:VDR
gene id: 9925:VDR
uniprot id: A0A1P8DAB5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family. NR1 subfamily.
messages: Cytoplasm
messages: Nucleus

9925:SLC12A4
gene id: 9925:SLC12A4
uniprot id: A0A452G615
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC12A transporter family.
messages: Membrane

9925:CCL5
gene id: 9925:CCL5
uniprot id: A0A452EWQ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine beta (chemokine CC) family.
messages: Secreted

9925:LOC108635911
gene id: 9925:LOC108635911
uniprot id: A0A452DMK1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the small GTPase superfamily. Ran family.
messages: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.
messages: Nucleus

9925:ADPRM
gene id: 9925:ADPRM
uniprot id: A0A452FJN2
names: Similarity
names: Subunit
messages: Belongs to the ADPRibase-Mn family.
messages: Monomer.

9925:LOC102184268
gene id: 9925:LOC102184268
uniprot id: A0A452E6T7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:GINS3
gene id: 9925:GINS3
uniprot id: A0A452FIC0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GINS3/PSF3 family.
messages: Chromosome
messages: Component of the GINS complex.
messages: Nucleus
messages: The GINS complex plays an essential role in the initiation of DNA replication.

9925:L3HYPDH
gene id: 9925:L3HYPDH
uniprot id: A0A452FAK7
names: Similarity
messages: Belongs to the proline racemase family.

9925:SULT6B1
gene id: 9925:SULT6B1
uniprot id: A0A452FYG5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9925:IDO2
gene id: 9925:IDO2
uniprot id: A0A452G1X3
names: Similarity
messages: Belongs to the indoleamine 2,3-dioxygenase family.

9925:UBE2H
gene id: 9925:UBE2H
uniprot id: A0A452FPZ3
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9925:SPIRE2
gene id: 9925:SPIRE2
uniprot id: A0A452F9M9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the spire family.
messages: Cell membrane
messages: Cytoplasmic vesicle membrane
messages: Membrane
messages: cytoskeleton

9925:GSKIP
gene id: 9925:GSKIP
uniprot id: A0A452EEJ4
names: Similarity
messages: Belongs to the GSKIP family.

9925:C1S
gene id: 9925:C1S
uniprot id: A0A452ECU4
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:CD9
gene id: 9925:CD9
uniprot id: B0LXL2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Cell membrane
messages: Membrane
messages: extracellular exosome

9925:NT5DC1
gene id: 9925:NT5DC1
uniprot id: A0A452G1E7
names: Similarity
messages: Belongs to the 5'(3')-deoxyribonucleotidase family.

9925:CDC37L1
gene id: 9925:CDC37L1
uniprot id: A0A452G209
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDC37 family.
messages: Cytoplasm

9925:GALR1
gene id: 9925:GALR1
uniprot id: A0A452DKN4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Membrane

9925:FCHO2
gene id: 9925:FCHO2
uniprot id: A0A452EBP5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FCHO family.
messages: clathrin-coated pit

9925:CASR
gene id: 9925:CASR
uniprot id: T1URP7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:NSUN6
gene id: 9925:NSUN6
uniprot id: A0A452ED23
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.

9925:SLC39A3
gene id: 9925:SLC39A3
uniprot id: F4ZW68
names: Subcellular Location Annotation
messages: Membrane

9925:TGM7
gene id: 9925:TGM7
uniprot id: A0A452F4K1
uniprot id: A0A452F4P4
names: Cofactor
names: Similarity
messages: Belongs to the transglutaminase superfamily. Transglutaminase family.
messages: Binds 1 Ca(2+) ion per subunit.

9925:GMPPA
gene id: 9925:GMPPA
uniprot id: A0A452EZM7
uniprot id: A0A452EZZ7
names: Similarity
messages: Belongs to the transferase hexapeptide repeat family.

9925:BDKRB1
gene id: 9925:BDKRB1
uniprot id: A0A452DNN3
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

9925:ROM1
gene id: 9925:ROM1
uniprot id: A0A452E321
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRPH2/ROM1 family.
messages: Membrane

9925:DMRTA1
gene id: 9925:DMRTA1
uniprot id: A0A452FS26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DMRT family.
messages: Nucleus

9925:CHD1
gene id: 9925:CHD1
uniprot id: A0A452G2U7
names: Subcellular Location Annotation
messages: Nucleus

9925:GTF2IRD1
gene id: 9925:GTF2IRD1
uniprot id: A0A452FC07
uniprot id: A0A452FC49
uniprot id: A0A452FCM0
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102177180
gene id: 9925:LOC102177180
uniprot id: A0A452E8D2
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:ASL
gene id: 9925:ASL
uniprot id: C6K4R7
names: Similarity
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

9925:LOC102172829
gene id: 9925:LOC102172829
uniprot id: A0A452EBD9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SNRPE
gene id: 9925:SNRPE
uniprot id: A0A452FW53
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP Sm proteins family.
messages: Nucleus
messages: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.
messages: cytosol

9925:PARP14
gene id: 9925:PARP14
uniprot id: A0A452F597
names: Similarity
messages: Belongs to the ARTD/PARP family.

9925:MKI67
gene id: 9925:MKI67
uniprot id: A0A452FUY8
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102184120
gene id: 9925:LOC102184120
uniprot id: A0A452EV66
names: Similarity
messages: Belongs to the TCAF family.

9925:NTSR1
gene id: 9925:NTSR1
uniprot id: A0A452G5N1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane

9925:FOXS1
gene id: 9925:FOXS1
uniprot id: A0A452EIG1
names: Subcellular Location Annotation
messages: Nucleus

9925:MSRB3
gene id: 9925:MSRB3
uniprot id: A0A452ECI2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit.
messages: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.

9925:SNX4
gene id: 9925:SNX4
uniprot id: A0A452EGT9
names: Similarity
messages: Belongs to the sorting nexin family.

9925:TARS
gene id: 9925:TARS
uniprot id: A0A452EHA4
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.

9925:TLR3
gene id: 9925:TLR3
uniprot id: A0A452ESD4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Toll-like receptor family.
messages: Membrane

9925:LSM12
gene id: 9925:LSM12
uniprot id: A0A452F456
names: Similarity
messages: Belongs to the LSM12 family.

9925:GPR17
gene id: 9925:GPR17
uniprot id: A0A452E1N3
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:THOC5
gene id: 9925:THOC5
uniprot id: A0A452G815
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the THOC5 family.
messages: Nucleus

9925:LOC102176897
gene id: 9925:LOC102176897
uniprot id: A0A452E7P2
names: Similarity
messages: Belongs to the aldo/keto reductase family.

9925:FLT4
gene id: 9925:FLT4
uniprot id: A0A452EI25
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
messages: Cell membrane
messages: Membrane

9925:NKX2-2
gene id: 9925:NKX2-2
uniprot id: A0A452G216
names: Subcellular Location Annotation
messages: Nucleus

9925:CXCL10
gene id: 9925:CXCL10
uniprot id: Q867B3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the intercrine alpha (chemokine CxC) family.
messages: Secreted

9925:UBE2E3
gene id: 9925:UBE2E3
uniprot id: A0A452E067
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9925:ENOPH1
gene id: 9925:ENOPH1
uniprot id: A0A452FUP0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.
messages: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Monomer.
messages: Nucleus

9925:LOC102186320
gene id: 9925:LOC102186320
uniprot id: A0A452DVS0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
messages: Monomer. Homodimer; disulfide-linked.
messages: Secreted
messages: The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.
messages: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.
messages: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.

9925:HOXB13
gene id: 9925:HOXB13
uniprot id: A0A452G8N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Abd-B homeobox family.
messages: Nucleus

9925:PKD1
gene id: 9925:PKD1
uniprot id: A0A452EV73
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polycystin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:SULT1B1
gene id: 9925:SULT1B1
uniprot id: A0A452DQX5
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9925:ELMO3
gene id: 9925:ELMO3
uniprot id: A0A452G901
names: Function
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

9925:RNF8
gene id: 9925:RNF8
uniprot id: A0A452DUR3
names: Caution
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.
messages: Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.
messages: Belongs to the CHFR family.
messages: Belongs to the RNF8 family.
messages: Cytoplasm
messages: E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains…
messages: Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.
messages: Midbody
messages: Nucleus
messages: The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.
messages: telomere

9925:SSRP1
gene id: 9925:SSRP1
uniprot id: A0A452E8Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SSRP1 family.
messages: Chromosome
messages: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
messages: Nucleus

9925:LGR4
gene id: 9925:LGR4
uniprot id: A0A452GBH5
names: Subcellular Location Annotation
messages: Membrane

9925:ORC3
gene id: 9925:ORC3
uniprot id: A0A452FWS3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ORC3 family.
messages: Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.
messages: Nucleus

9925:VAX1
gene id: 9925:VAX1
uniprot id: A0A452DMM9
names: Subcellular Location Annotation
messages: Nucleus

9925:PPP6R3
gene id: 9925:PPP6R3
uniprot id: A0A452FDQ2
names: Similarity
messages: Belongs to the SAPS family.

9925:LOC102173106
gene id: 9925:LOC102173106
uniprot id: A0A452DNY7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:SLC41A3
gene id: 9925:SLC41A3
uniprot id: A0A452ENW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Acts as a magnesium transporter.
messages: Belongs to the SLC41A transporter family.
messages: Membrane

9925:ALG3
gene id: 9925:ALG3
uniprot id: A0A452ESW1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.
messages: Belongs to the glycosyltransferase 58 family.
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:LAMTOR1
gene id: 9925:LAMTOR1
uniprot id: A0A452EE38
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LAMTOR1 family.
messages: Endosome membrane
messages: Late endosome membrane
messages: Lysosome membrane

9925:CHPF
gene id: 9925:CHPF
uniprot id: A0A452E9P2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
messages: Golgi stack membrane
messages: Membrane

9925:ZC2HC1C
gene id: 9925:ZC2HC1C
uniprot id: A0A452G591
names: Similarity
messages: Belongs to the ZC2HC1 family.

9925:DZIP1
gene id: 9925:DZIP1
uniprot id: A0A452DT09
uniprot id: A0A452DT17
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DZIP C2H2-type zinc-finger protein family.
messages: cilium basal body

9925:LOC102182562
gene id: 9925:LOC102182562
uniprot id: E7EC28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thymosin beta family.
messages: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
messages: cytoskeleton

9925:RGR
gene id: 9925:RGR
uniprot id: A0A452FZB3
names: Subcellular Location Annotation
messages: Membrane

9925:C14H8orf46
gene id: 9925:C14H8orf46
uniprot id: A0A452E5I6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vexin family.
messages: Cell membrane
messages: Membrane
messages: Nucleus

9925:LOC102177871
gene id: 9925:LOC102177871
uniprot id: A0A452DW84
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:HS3ST6
gene id: 9925:HS3ST6
uniprot id: A0A452FBH4
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9925:RPGRIP1L
gene id: 9925:RPGRIP1L
uniprot id: A0A452EW23
names: Similarity
messages: Belongs to the RPGRIP1 family.

9925:FGF11
gene id: 9925:FGF11
uniprot id: A0A452DUH7
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9925:MPP6
gene id: 9925:MPP6
uniprot id: A0A452F828
uniprot id: A0A452F838
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MAGUK family.
messages: Cell membrane

9925:INIP
gene id: 9925:INIP
uniprot id: A0A8C2PKD9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SOSS-C family.
messages: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).
messages: Component of the SOSS complex.
messages: Nucleus

9925:SERINC3
gene id: 9925:SERINC3
uniprot id: A0A452FEG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TDE1 family.
messages: Membrane

9925:LOC102188434
gene id: 9925:LOC102188434
uniprot id: A0A452EEG7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase IV family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.
messages: Membrane
messages: Mitochondrion inner membrane

9925:PPIF
gene id: 9925:PPIF
uniprot id: A0A452DKJ7
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

9925:CPN1
gene id: 9925:CPN1
uniprot id: A0A452DSP2
names: Similarity
messages: Belongs to the peptidase M14 family.

9925:TFAP2C
gene id: 9925:TFAP2C
uniprot id: A0A452EUP1
uniprot id: A0A8C2QW26
names: Similarity
messages: Belongs to the AP-2 family.

9925:NANOG
gene id: 9925:NANOG
uniprot id: F8UVM8
uniprot id: I7FNK5
names: Subcellular Location Annotation
messages: Nucleus

9925:DPYSL2
gene id: 9925:DPYSL2
uniprot id: A0A452G996
uniprot id: A0A452G9S2
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.

9925:MTF2
gene id: 9925:MTF2
uniprot id: A0A452FX85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Polycomblike family.
messages: Nucleus

9925:AIMP2
gene id: 9925:AIMP2
uniprot id: A0A452ENH7
names: Subcellular Location Annotation
messages: Nucleus
messages: cytosol

9925:RPL29
gene id: 9925:RPL29
uniprot id: A0A452EI45
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL29 family.

9925:HARS
gene id: 9925:HARS
uniprot id: A0A452F498
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

9925:FAM45A
gene id: 9925:FAM45A
uniprot id: A0A452FF34
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DENND10 family.
messages: Endosome
messages: Late endosome

9925:TTC39A
gene id: 9925:TTC39A
uniprot id: A0A452DQE9
uniprot id: A0A452DQF5
names: Similarity
messages: Belongs to the TTC39 family.

9925:SV2B
gene id: 9925:SV2B
uniprot id: A0A452G3Q3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily.
messages: Membrane
messages: synaptic vesicle membrane

9925:ST3GAL5
gene id: 9925:ST3GAL5
uniprot id: S5M3Z0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9925:ASPDH
gene id: 9925:ASPDH
uniprot id: A0A452FQL2
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.

9925:PLD1
gene id: 9925:PLD1
uniprot id: A0A452E2A1
uniprot id: A0A452E2C3
uniprot id: A0A452E2F5
names: Similarity
messages: Belongs to the phospholipase D family.

9925:TSEN15
gene id: 9925:TSEN15
uniprot id: A0A452FID9
names: Similarity
messages: Belongs to the SEN15 family.

9925:MAP3K9
gene id: 9925:MAP3K9
uniprot id: A0A452EWR0
uniprot id: A0A452EWR9
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Homodimerization via the leucine zipper domains is required for autophosphorylation.

9925:RNASEH2A
gene id: 9925:RNASEH2A
uniprot id: A0A452ELC4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family. Eukaryotic subfamily.
messages: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

9925:FAM151A
gene id: 9925:FAM151A
uniprot id: A0A452EIX3
names: Similarity
messages: Belongs to the FAM151 family.

9925:CDCA8
gene id: 9925:CDCA8
uniprot id: A0A452G8W1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the borealin family.
messages: centromere

9925:SNRPB
gene id: 9925:SNRPB
uniprot id: A0A452G2U0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the snRNP SmB/SmN family.
messages: Nucleus

9925:ST6GAL1
gene id: 9925:ST6GAL1
uniprot id: A0A452EGM7
uniprot id: E9NST4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 29 family.
messages: Membrane

9925:LOC102174495
gene id: 9925:LOC102174495
uniprot id: P02102
names: Function
names: Similarity
names: Subunit
names: Tissue Specificity
messages: Belongs to the globin family.
messages: Beta-type chain found in early embryos.
messages: Heterotetramer of two epsilon chains and two alpha chains.
messages: Red blood cells.

9925:PHLDA3
gene id: 9925:PHLDA3
uniprot id: A0A452EGJ6
names: Subcellular Location Annotation
messages: Cytoplasm

9925:LOC102177619
gene id: 9925:LOC102177619
uniprot id: A0A452DN28
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:MCMBP
gene id: 9925:MCMBP
uniprot id: A0A452EUF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCMBP family.
messages: Nucleus

9925:SERBP1
gene id: 9925:SERBP1
uniprot id: A0A452G8G7
names: Similarity
messages: Belongs to the SERBP1-HABP4 family.

9925:AMIGO3
gene id: 9925:AMIGO3
uniprot id: A0A452DV19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. AMIGO family.
messages: Membrane

9925:OCLN
gene id: 9925:OCLN
uniprot id: A0A452DMX9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELL/occludin family.
messages: Cell membrane
messages: May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
messages: Membrane
messages: tight junction

9925:ETF1
gene id: 9925:ETF1
uniprot id: A0A452E0V0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm

9925:MRPL28
gene id: 9925:MRPL28
uniprot id: A0A8C2R8R9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

9925:TSPAN17
gene id: 9925:TSPAN17
uniprot id: A0A452EPR7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9925:ACOT8
gene id: 9925:ACOT8
uniprot id: A0A452F0N9
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9925:CNOT2
gene id: 9925:CNOT2
uniprot id: A0A452FJ91
names: Similarity
messages: Belongs to the CNOT2/3/5 family.

9925:FOXO1
gene id: 9925:FOXO1
uniprot id: A0A452F3R8
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:SPDL1
gene id: 9925:SPDL1
uniprot id: A0A452EQ60
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Spindly family.
messages: Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.
messages: Nucleus
messages: Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.
messages: centrosome
messages: kinetochore
messages: spindle pole

9925:LOC102186527
gene id: 9925:LOC102186527
uniprot id: A0A452FTU5
names: Similarity
messages: Belongs to the cystatin family.

9925:SARS
gene id: 9925:SARS
uniprot id: A0A452FAB7
names: Similarity
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.

9925:PHF5A
gene id: 9925:PHF5A
uniprot id: A0A8C2QWM2
names: Similarity
messages: Belongs to the PHF5 family.

9925:CD53
gene id: 9925:CD53
uniprot id: A0A452EJY8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9925:CD3D
gene id: 9925:CD3D
uniprot id: A0A452DT34
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

9925:ATG2A
gene id: 9925:ATG2A
uniprot id: A0A452EY85
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATG2 family.
messages: Endoplasmic reticulum membrane
messages: Lipid droplet
messages: Preautophagosomal structure membrane

9925:PIM3
gene id: 9925:PIM3
uniprot id: A0A452F4S0
names: Function
names: Similarity
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.
messages: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.

9925:WASF3
gene id: 9925:WASF3
uniprot id: A0A452F1M3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SCAR/WAVE family.
messages: Binds actin and the Arp2/3 complex.
messages: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
messages: cytoskeleton

9925:GPRIN1
gene id: 9925:GPRIN1
uniprot id: A0A452DZ03
names: Function
messages: May be involved in neurite outgrowth.

9925:ISOC1
gene id: 9925:ISOC1
uniprot id: A0A452F7M8
names: Similarity
messages: Belongs to the isochorismatase family.

9925:GIPC3
gene id: 9925:GIPC3
uniprot id: A0A452F7A4
names: Similarity
messages: Belongs to the GIPC family.

9925:LOC100860813
gene id: 9925:LOC100860813
uniprot id: A0A452E4F7
names: Similarity
messages: Belongs to the MHC class II family.

9925:PGLYRP1
gene id: 9925:PGLYRP1
uniprot id: A0A452EEM4
names: Function
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
messages: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems.

9925:EARS2
gene id: 9925:EARS2
uniprot id: A0A452FNV1
names: Function
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).

9925:LOC108633924
gene id: 9925:LOC108633924
uniprot id: A0A452E4C3
names: Similarity
messages: Belongs to the histone H3 family.

9925:MRPL30
gene id: 9925:MRPL30
uniprot id: A0A452FWK2
names: Similarity
messages: Belongs to the universal ribosomal protein uL30 family.

9925:CCDC94
gene id: 9925:CCDC94
uniprot id: A0A452EXZ2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CWC16 family. YJU2 subfamily.
messages: Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.
messages: Nucleus
messages: Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex.

9925:PRRX1
gene id: 9925:PRRX1
uniprot id: A0A452E2W3
uniprot id: A0A452E2X5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the paired homeobox family.
messages: Nucleus

9925:LOC102189370
gene id: 9925:LOC102189370
uniprot id: A0A452F9C0
names: Function
names: Similarity
messages: Belongs to the GST superfamily. Omega family.
messages: Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).

9925:EPN3
gene id: 9925:EPN3
uniprot id: A0A452FS77
names: Similarity
messages: Belongs to the epsin family.

9925:MSLN
gene id: 9925:MSLN
uniprot id: A0A452DRG4
names: Similarity
messages: Belongs to the mesothelin family.

9925:NMNAT3
gene id: 9925:NMNAT3
uniprot id: A0A452G700
names: Similarity
messages: Belongs to the eukaryotic NMN adenylyltransferase family.

9925:LOC102184830
gene id: 9925:LOC102184830
uniprot id: A0A452DZI1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TMTC4
gene id: 9925:TMTC4
uniprot id: A0A452ENZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMTC family.
messages: Endoplasmic reticulum
messages: Membrane

9925:CHMP7
gene id: 9925:CHMP7
uniprot id: A0A452FZ86
names: Similarity
messages: Belongs to the SNF7 family.

9925:SKAP2
gene id: 9925:SKAP2
uniprot id: A0A452E9S5
names: Similarity
messages: Belongs to the SKAP family.

9925:MMP13
gene id: 9925:MMP13
uniprot id: A0A452FGN2
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.

9925:LOC102191297
gene id: 9925:LOC102191297
uniprot id: A0A452DYN3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9925:DHH
gene id: 9925:DHH
uniprot id: A0A452E142
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the hedgehog family.
messages: Cell membrane
messages: Endoplasmic reticulum membrane
messages: Golgi apparatus membrane
messages: Membrane
messages: Multimer.
messages: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
messages: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

9925:ITGB5
gene id: 9925:ITGB5
uniprot id: A0A452EVX2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin beta chain family.
messages: Cell membrane
messages: Membrane

9925:MIS12
gene id: 9925:MIS12
uniprot id: A0A452DX06
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the mis12 family.
messages: Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.
messages: kinetochore

9925:KHSRP
gene id: 9925:KHSRP
uniprot id: A0A452GA60
uniprot id: A0A452GAP9
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC108638212
gene id: 9925:LOC108638212
uniprot id: A0A452DPH3
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:TP53INP2
gene id: 9925:TP53INP2
uniprot id: A0A452G2M2
names: Subcellular Location Annotation
messages: PML body
messages: autophagosome
messages: cytosol

9925:USP4
gene id: 9925:USP4
uniprot id: A0A452F0Y7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase C19 family.
messages: Cytoplasm
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.
messages: Nucleus

9925:MBOAT7
gene id: 9925:MBOAT7
uniprot id: A0A452FD06
names: Subcellular Location Annotation
messages: Membrane

9925:HR
gene id: 9925:HR
uniprot id: A0A452FZ90
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the JHDM2 histone demethylase family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.
messages: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.
messages: Nucleus
messages: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.

9925:XRCC6
gene id: 9925:XRCC6
uniprot id: A0A452EDQ6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ku70 family.
messages: Nucleus

9925:PNPLA1
gene id: 9925:PNPLA1
uniprot id: A0A452FE16
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:FABP3
gene id: 9925:FABP3
uniprot id: Q6S4N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
messages: Cytoplasm

9925:TAF6
gene id: 9925:TAF6
uniprot id: A0A452GBB3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TAF6 family.
messages: Nucleus

9925:ADCY5
gene id: 9925:ADCY5
uniprot id: A0A452FR89
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
messages: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
messages: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
messages: Membrane

9925:ACTL6B
gene id: 9925:ACTL6B
uniprot id: A0A452F0X5
names: Similarity
messages: Belongs to the actin family.

9925:HOXC8
gene id: 9925:HOXC8
uniprot id: A0A1S5UZS7
names: Subcellular Location Annotation
messages: Nucleus

9925:TP53
gene id: 9925:TP53
uniprot id: A0A452G0A3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
messages: Belongs to the p53 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds DNA as a homotetramer.
messages: Cytoplasm
messages: Endoplasmic reticulum
messages: Mitochondrion matrix
messages: Nucleus
messages: PML body
messages: centrosome

9925:ORAI2
gene id: 9925:ORAI2
uniprot id: A0A452E2B1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Orai family.
messages: Membrane

9925:SLC26A5
gene id: 9925:SLC26A5
uniprot id: A0A452FVN6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
messages: Membrane
messages: Voltage-sensitive motor protein that drives outer hair cell (OHC) electromotility (eM) and participates in sound amplification in the hearing organ. Converts changes in the transmembrane electric potential into mechanical displacements resulting in the coupling of its expansion to movement of a charged voltage sensor across the lipid membrane. The nature of the voltage sensor is not completely clear, and two models compete. In the first model, acts as an incomplete transporter where intracellular chloride anion acts as extrinsic voltage sensor that drives conformational change in the protein which is sufficient to produce a length change in the plane of the membrane and hence in the length of the OHC. The second model in which multiple charged amino acid residues are distributed at the intracellular and extracellular membrane interfaces that form an intrinsic voltage sensor, whose movement produces the non-linear capacitance (NLC). However, the effective voltage sensor may be the result of a hybrid voltage sensor, assembled from intrinsic charge (charged residues) and extrinsic charge (bound anion). Notably, binding of anions to the anion-binding pocket partially neutralizes the intrinsic positive charge rather than to form an electrically negative sensor, therefore remaining charge may serve as voltage sensor that, after depolarization, moves from down (expanded state) to up (contracted) conformation, which is accompanied by an eccentric contraction of the intermembrane cross-sectional area of the protein as well as a major increase in the hydrophobic thickness of the protein having as consequences the plasma membrane thickening and the cell contraction after membrane depolarization. The anion-binding pocket transits from the inward-open (Down) state, where it is exposed toward the intracellular solvent in the absence of anion, to the occluded (Up) state upon anion binding. Salicylate competes for the anion-binding site and inhibits the voltage-sensor movement, and…

9925:LOC102169851
gene id: 9925:LOC102169851
uniprot id: A0A452EMZ0
names: Similarity
messages: Belongs to the cytochrome P450 family.

9925:RBFOX2
gene id: 9925:RBFOX2
uniprot id: A0A452EJF3
uniprot id: A0A8C2N548
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: RNA-binding protein that regulates alternative splicing events.

9925:LOC102168381
gene id: 9925:LOC102168381
uniprot id: A0A452DNG6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytochrome P450 family.
messages: Cytochromes P450 are a group of heme-thiolate monooxygenases.
messages: Endoplasmic reticulum membrane
messages: Microsome membrane

9925:GJA3
gene id: 9925:GJA3
uniprot id: A0A452DNZ8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family. Alpha-type (group II) subfamily.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9925:LSR
gene id: 9925:LSR
uniprot id: A0A452ESE3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the immunoglobulin superfamily. LISCH7 family.
messages: Membrane
messages: tight junction

9925:MMP14
gene id: 9925:MMP14
uniprot id: Q9XSP0
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M10A family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Can bind about 5 Ca(2+) ions per subunit.
messages: Cytoplasm
messages: Melanosome

9925:PTGIR
gene id: 9925:PTGIR
uniprot id: A0A452EWA8
names: Similarity
messages: Belongs to the G-protein coupled receptor 1 family.

9925:KIAA1429
gene id: 9925:KIAA1429
uniprot id: A0A452ET57
uniprot id: A0A452ET72
names: Similarity
messages: Belongs to the vir family.

9925:PLA2G2F
gene id: 9925:PLA2G2F
uniprot id: A0A452EVZ9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phospholipase A2 family.
messages: Binds 1 Ca(2+) ion per subunit.
messages: Secreted

9925:ATF7IP
gene id: 9925:ATF7IP
uniprot id: A0A452DQD7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCAF family.
messages: Nucleus

9925:RAB3GAP1
gene id: 9925:RAB3GAP1
uniprot id: A0A452DRR5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Rab3-GAP catalytic subunit family.
messages: Cytoplasm
messages: Endoplasmic reticulum

9925:TMEM205
gene id: 9925:TMEM205
uniprot id: A0A452DU54
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM205 family.
messages: Membrane

9925:IFIH1
gene id: 9925:IFIH1
uniprot id: A0A452FBA2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the helicase family. RLR subfamily.
messages: Cytoplasm

9925:MYF6
gene id: 9925:MYF6
uniprot id: D9IVD7
names: Subcellular Location Annotation
messages: Nucleus

9925:INSRR
gene id: 9925:INSRR
uniprot id: A0A452FCS9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
messages: Membrane

9925:PFDN4
gene id: 9925:PFDN4
uniprot id: A0A452F9W2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
messages: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.

9925:DNAJA1
gene id: 9925:DNAJA1
uniprot id: A0A452ERL0
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102182595
gene id: 9925:LOC102182595
uniprot id: A0A8C2R572
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PCSK5
gene id: 9925:PCSK5
uniprot id: A0A452DQZ9
uniprot id: A0A452DR00
uniprot id: A0A452DRA5
names: Similarity
messages: Belongs to the peptidase S8 family.

9925:ADGRL2
gene id: 9925:ADGRL2
uniprot id: A0A452F6J1
uniprot id: A0A452F736
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102180732
gene id: 9925:LOC102180732
uniprot id: A0A452DS34
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:EDN3
gene id: 9925:EDN3
uniprot id: A0A452EYV9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endothelin/sarafotoxin family.
messages: Secreted

9925:LTV1
gene id: 9925:LTV1
uniprot id: A0A452EIC8
names: Similarity
messages: Belongs to the LTV1 family.

9925:LOC108633177
gene id: 9925:LOC108633177
uniprot id: A0A452E2Q8
names: Similarity
messages: Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.

9925:SETD6
gene id: 9925:SETD6
uniprot id: A0A452DX78
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.
messages: Nucleus
messages: Protein-lysine N-methyltransferase.

9925:CHMP4C
gene id: 9925:CHMP4C
uniprot id: A0A452DSF9
names: Similarity
messages: Belongs to the SNF7 family.

9925:RPS2
gene id: 9925:RPS2
uniprot id: A0A452FMT2
names: Similarity
messages: Belongs to the universal ribosomal protein uS5 family.

9925:MED18
gene id: 9925:MED18
uniprot id: A0A452FCN3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Mediator complex subunit 18 family.
messages: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
messages: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
messages: Nucleus

9925:TSHZ1
gene id: 9925:TSHZ1
uniprot id: A0A452EVF0
names: Similarity
messages: Belongs to the teashirt C2H2-type zinc-finger protein family.

9925:DHTKD1
gene id: 9925:DHTKD1
uniprot id: A0A452EC98
names: Similarity
messages: Belongs to the alpha-ketoglutarate dehydrogenase family.

9925:TNFSF13
gene id: 9925:TNFSF13
uniprot id: D3Y602
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tumor necrosis factor family.
messages: Secreted

9925:LOC102172432
gene id: 9925:LOC102172432
uniprot id: A0A452E3H3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UDP-glycosyltransferase family.
messages: Membrane

9925:CCDC65
gene id: 9925:CCDC65
uniprot id: A0A452E0R5
names: Subcellular Location Annotation
messages: flagellum axoneme

9925:TP53RK
gene id: 9925:TP53RK
uniprot id: A0A452G6K2
names: Similarity
messages: Belongs to the protein kinase superfamily. BUD32 family.

9925:LOC102188953
gene id: 9925:LOC102188953
uniprot id: A0A8C2RNF3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCTS1 family.
messages: Cytoplasm

9925:SULT4A1
gene id: 9925:SULT4A1
uniprot id: A0A452F9S3
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9925:PRKD1
gene id: 9925:PRKD1
uniprot id: A0A452F161
uniprot id: A0A452F1G8
names: Activity Regulation
names: Similarity
names: Subcellular Location Annotation
messages: Activated by DAG and phorbol esters.
messages: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
messages: Cytoplasm
messages: Membrane

9925:YBEY
gene id: 9925:YBEY
uniprot id: A0A452DW38
names: Similarity
messages: Belongs to the endoribonuclease YbeY family.

9925:LYZL6
gene id: 9925:LYZL6
uniprot id: A0A452E4F6
names: Similarity
messages: Belongs to the glycosyl hydrolase 22 family.

9925:PAG-6
gene id: 9925:PAG-6
uniprot id: Q9TTX0
names: Similarity
messages: Belongs to the peptidase A1 family.

9925:ZHX3
gene id: 9925:ZHX3
uniprot id: A0A452FGZ1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9925:LOC102183297
gene id: 9925:LOC102183297
uniprot id: A0A452FY31
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

9925:EIF3B
gene id: 9925:EIF3B
uniprot id: A0A452E278
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit B family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with UPF2. Interacts with METTL3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
messages: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: The RRM domain mediates interaction with EIF3J.

9925:PDC
gene id: 9925:PDC
uniprot id: A0A452E229
names: Similarity
messages: Belongs to the phosducin family.

9925:SRP9
gene id: 9925:SRP9
uniprot id: A0A452DSJ6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SRP9 family.
messages: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.
messages: Cytoplasm

9925:HADHB
gene id: 9925:HADHB
uniprot id: A0A452FZ72
names: Similarity
messages: Belongs to the thiolase-like superfamily. Thiolase family.

9925:GLS
gene id: 9925:GLS
uniprot id: A0A452DX27
uniprot id: A0A452DXG4
names: Similarity
messages: Belongs to the glutaminase family.

9925:AURKA
gene id: 9925:AURKA
uniprot id: A0A452FYJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
messages: centrosome

9925:COMP
gene id: 9925:COMP
uniprot id: A0A452EQ17
names: Caution
names: Similarity
messages: Belongs to the thrombospondin family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:BAZ1A
gene id: 9925:BAZ1A
uniprot id: A0A452F9I7
names: Subcellular Location Annotation
messages: Nucleus

9925:SF3B3
gene id: 9925:SF3B3
uniprot id: A0A452FB80
names: Subcellular Location Annotation
messages: Nucleus

9925:LOC102172353
gene id: 9925:LOC102172353
uniprot id: A0A452EES7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LOC102189976
gene id: 9925:LOC102189976
uniprot id: A0A452E618
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:CLTB
gene id: 9925:CLTB
uniprot id: A0A452F3N4
uniprot id: A0A452F3Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the clathrin light chain family.
messages: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.
messages: Cytoplasmic vesicle membrane
messages: coated pit

9925:ITGA9
gene id: 9925:ITGA9
uniprot id: A0A452FI26
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9925:PCNX4
gene id: 9925:PCNX4
uniprot id: A0A452GB60
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pecanex family.
messages: Membrane

9925:CACNA2D3
gene id: 9925:CACNA2D3
uniprot id: A0A452FS12
uniprot id: A0A452FSB0
names: Similarity
messages: Belongs to the calcium channel subunit alpha-2/delta family.

9925:KRTCAP3
gene id: 9925:KRTCAP3
uniprot id: A0A452G6U8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM54 family.
messages: Membrane

9925:HSD17B7
gene id: 9925:HSD17B7
uniprot id: A0A452DSV0
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.

9925:RNASEH2B
gene id: 9925:RNASEH2B
uniprot id: A0A452F3W4
uniprot id: A1E460
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNase H2 subunit B family.
messages: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
messages: Nucleus
messages: The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C.

9925:ADPRHL2
gene id: 9925:ADPRHL2
uniprot id: A0A452E8X2
names: Similarity
messages: Belongs to the ADP-ribosylglycohydrolase family.

9925:YWHAZ
gene id: 9925:YWHAZ
uniprot id: A0A097C2Z1
names: Similarity
messages: Belongs to the 14-3-3 family.

9925:RIPPLY2
gene id: 9925:RIPPLY2
uniprot id: A0A8C2NPZ9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ripply family.
messages: Nucleus

9925:SFRP1
gene id: 9925:SFRP1
uniprot id: A0A452EKX5
names: Caution
names: Similarity
messages: Belongs to the secreted frizzled-related protein (sFRP) family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:MRPL51
gene id: 9925:MRPL51
uniprot id: A0A452E827
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mitochondrion-specific ribosomal protein mL51 family.
messages: Mitochondrion

9925:USP2
gene id: 9925:USP2
uniprot id: A0A452DNV5
uniprot id: A0A452DNZ3
names: Function
names: Similarity
messages: Belongs to the peptidase C19 family.
messages: Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.

9925:CERS3
gene id: 9925:CERS3
uniprot id: A0A452G378
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus

9925:RIN1
gene id: 9925:RIN1
uniprot id: A0A452G250
names: Similarity
messages: Belongs to the RIN (Ras interaction/interference) family.

9925:ARHGEF3
gene id: 9925:ARHGEF3
uniprot id: A0A452ENX5
names: Function
names: Subcellular Location Annotation
messages: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
messages: Cytoplasm

9925:NR2F1
gene id: 9925:NR2F1
uniprot id: A0A452E513
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nuclear hormone receptor family.
messages: Nucleus

9925:SUMF1
gene id: 9925:SUMF1
uniprot id: A0A452G7P6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sulfatase-modifying factor family.
messages: Endoplasmic reticulum lumen

9925:NPEPL1
gene id: 9925:NPEPL1
uniprot id: A0A452FEG1
names: Similarity
messages: Belongs to the peptidase M17 family.

9925:ADAMTS19
gene id: 9925:ADAMTS19
uniprot id: A0A452F7E9
names: Caution
names: Cofactor
names: Subcellular Location Annotation
messages: Binds 1 zinc ion per subunit.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: extracellular matrix

9925:PLPPR3
gene id: 9925:PLPPR3
uniprot id: A0A452DXY9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PA-phosphatase related phosphoesterase family.
messages: Membrane

9925:DNAJC18
gene id: 9925:DNAJC18
uniprot id: A0A452FPW6
names: Subcellular Location Annotation
messages: Endoplasmic reticulum membrane
messages: Membrane

9925:MFSD6
gene id: 9925:MFSD6
uniprot id: A0A452ED57
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the major facilitator superfamily. MFSD6 family.
messages: Membrane

9925:GJB4
gene id: 9925:GJB4
uniprot id: A0A452E199
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A connexon is composed of a hexamer of connexins.
messages: Belongs to the connexin family.
messages: Cell membrane
messages: Membrane
messages: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
messages: gap junction

9925:OVCA2
gene id: 9925:OVCA2
uniprot id: A0A8C2RV39
names: Similarity
messages: Belongs to the LovG family.

9925:LOC106503501
gene id: 9925:LOC106503501
uniprot id: A0A452DY82
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2A family.
messages: Chromosome
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:ELOVL5
gene id: 9925:ELOVL5
uniprot id: A4PBF5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ELO family. ELOVL5 subfamily.
messages: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: dendrite

9925:EIF4A3
gene id: 9925:EIF4A3
uniprot id: A0A452FXC4
names: Similarity
messages: Belongs to the DEAD box helicase family.

9925:PSME2
gene id: 9925:PSME2
uniprot id: A0A452FV15
names: Similarity
messages: Belongs to the PA28 family.

9925:KIZ
gene id: 9925:KIZ
uniprot id: A0A452FDZ3
uniprot id: A0A452FEN7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the kizuna family.
messages: Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
messages: centrosome
messages: cilium basal body

9925:ATP13A4
gene id: 9925:ATP13A4
uniprot id: A0A452EDF9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.
messages: Membrane

9925:HBP1
gene id: 9925:HBP1
uniprot id: A0A452FXT6
uniprot id: A0A8C2NS51
names: Function
names: Subcellular Location Annotation
messages: Nucleus
messages: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

9925:LOC102183891
gene id: 9925:LOC102183891
uniprot id: A0A452DNT1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:BCHE
gene id: 9925:BCHE
uniprot id: A0A452G909
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type-B carboxylesterase/lipase family.
messages: Secreted

9925:ALPL
gene id: 9925:ALPL
uniprot id: A0A452EAH5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the alkaline phosphatase family.
messages: Binds 1 Mg(2+) ion.
messages: Binds 2 Zn(2+) ions.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

9925:NFE2L3
gene id: 9925:NFE2L3
uniprot id: A0A452E175
names: Similarity
messages: Belongs to the bZIP family. CNC subfamily.

9925:ITGA3
gene id: 9925:ITGA3
uniprot id: A0A452EQV8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the integrin alpha chain family.
messages: Membrane

9925:MYRF
gene id: 9925:MYRF
uniprot id: A0A452DPJ8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MRF family.
messages: Membrane

9925:GDNF
gene id: 9925:GDNF
uniprot id: A0A452FSD7
uniprot id: A0A8C2R844
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TGF-beta family. GDNF subfamily.
messages: Secreted

9925:CDC42SE2
gene id: 9925:CDC42SE2
uniprot id: A0A452FLB2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CDC42SE/SPEC family.
messages: Cell membrane
messages: Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.
messages: Membrane
messages: Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.
messages: cytoskeleton

9925:ANXA2
gene id: 9925:ANXA2
uniprot id: A0A452DSB1
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: A pair of annexin repeats may form one binding site for calcium and phospholipid.
messages: Belongs to the annexin family.
messages: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.
messages: Membrane
messages: basement membrane

9925:LOC102182538
gene id: 9925:LOC102182538
uniprot id: A0A3G5ECF5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PMG family.
messages: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
messages: Interacts with hair keratins.

9925:HACD4
gene id: 9925:HACD4
uniprot id: A0A452DST9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the very long-chain fatty acids dehydratase HACD family.
messages: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
messages: Endoplasmic reticulum membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:FUCA2
gene id: 9925:FUCA2
uniprot id: A0A452FCG0
names: Function
names: Similarity
names: Subunit
messages: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
messages: Belongs to the glycosyl hydrolase 29 family.
messages: Homotetramer.

9925:TOLLIP
gene id: 9925:TOLLIP
uniprot id: A0A452ECK1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tollip family.
messages: Cytoplasm

9925:RPL26
gene id: 9925:RPL26
uniprot id: A0A452G1I8
names: Similarity
messages: Belongs to the universal ribosomal protein uL24 family.

9925:TM4SF18
gene id: 9925:TM4SF18
uniprot id: A0A8C2N742
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the L6 tetraspanin family.
messages: Membrane

9925:TMED3
gene id: 9925:TMED3
uniprot id: A0A452DXF0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EMP24/GP25L family.
messages: Endoplasmic reticulum membrane
messages: Endoplasmic reticulum-Golgi intermediate compartment membrane
messages: Membrane
messages: cis-Golgi network membrane

9925:LOC102172503
gene id: 9925:LOC102172503
uniprot id: A0A452EGJ4
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eIF-3 subunit F family.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.
messages: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.
messages: Cytoplasm
messages: Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

9925:EFNA4
gene id: 9925:EFNA4
uniprot id: A0A452DXJ2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ephrin family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:MINPP1
gene id: 9925:MINPP1
uniprot id: A0A452EEL3
names: Similarity
messages: Belongs to the histidine acid phosphatase family. MINPP1 subfamily.

9925:SFXN4
gene id: 9925:SFXN4
uniprot id: A0A452E9T8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sideroflexin family.
messages: Membrane

9925:SLCO5A1
gene id: 9925:SLCO5A1
uniprot id: A0A452FLE9
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the organo anion transporter (TC 2.A.60) family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

9925:JUN
gene id: 9925:JUN
uniprot id: A0A452DQ92
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bZIP family. Jun subfamily.
messages: Nucleus

9925:LOC102176442
gene id: 9925:LOC102176442
uniprot id: A0A452DU47
names: Similarity
messages: Belongs to the globin family.

9925:DR1
gene id: 9925:DR1
uniprot id: A0A452FGD2
names: Similarity
messages: Belongs to the NC2 beta/DR1 family.

9925:NAPRT
gene id: 9925:NAPRT
uniprot id: A0A8C2NN19
names: Function
names: PTM
names: Similarity
messages: Belongs to the NAPRTase family.
messages: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.
messages: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.

9925:LOC108634038
gene id: 9925:LOC108634038
uniprot id: A0A452FBC4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:C7H19orf25
gene id: 9925:C7H19orf25
uniprot id: A0A452ERF6
names: Similarity
messages: Belongs to the UPF0449 family.

9925:POLD1
gene id: 9925:POLD1
uniprot id: A0A452F6A8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DNA polymerase type-B family.
messages: Nucleus

9925:LOC102187492
gene id: 9925:LOC102187492
uniprot id: A0A452DTZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:PREP
gene id: 9925:PREP
uniprot id: A0A452F941
names: Similarity
messages: Belongs to the peptidase S9A family.

9925:LOC102181069
gene id: 9925:LOC102181069
uniprot id: A0A452EF45
names: Similarity
messages: Belongs to the sulfotransferase 1 family.

9925:ZHX1
gene id: 9925:ZHX1
uniprot id: A0A452E8D7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ZHX family.
messages: Nucleus

9925:MFSD8
gene id: 9925:MFSD8
uniprot id: A0A452FX70
names: Subcellular Location Annotation
messages: Membrane

9925:UBE2G2
gene id: 9925:UBE2G2
uniprot id: A0A452DSW7
names: Similarity
messages: Belongs to the ubiquitin-conjugating enzyme family.

9925:LOC102175297
gene id: 9925:LOC102175297
uniprot id: A0A452DZ94
names: Cofactor
names: Function
names: Subunit
messages: Binds 1 zinc ion per subunit.
messages: Homotetramer.
messages: Involved in the regulation of homocysteine metabolism.

9925:HABP4
gene id: 9925:HABP4
uniprot id: A0A452F5C8
names: Similarity
messages: Belongs to the SERBP1-HABP4 family.

9925:FGF17
gene id: 9925:FGF17
uniprot id: A0A8C2P0Z0
names: Similarity
messages: Belongs to the heparin-binding growth factors family.

9925:NUP50
gene id: 9925:NUP50
uniprot id: A0A452G5Q7
names: Subcellular Location Annotation
messages: nuclear pore complex

9925:NDUFB1
gene id: 9925:NDUFB1
uniprot id: A0A452ERZ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
messages: Belongs to the complex I NDUFB1 subunit family.
messages: Complex I is composed of 45 different subunits.
messages: Mitochondrion inner membrane

9925:HMX3
gene id: 9925:HMX3
uniprot id: A0A452E634
names: Subcellular Location Annotation
messages: Nucleus

9925:DES
gene id: 9925:DES
uniprot id: A0A452DWL1
names: Similarity
messages: Belongs to the intermediate filament family.

9925:NOG
gene id: 9925:NOG
uniprot id: A0A2Z4FR29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the noggin family.
messages: Homodimer.
messages: Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.
messages: Secreted

9925:TRPC3
gene id: 9925:TRPC3
uniprot id: A0A452G4L8
names: Subcellular Location Annotation
messages: Membrane

9925:BAAT
gene id: 9925:BAAT
uniprot id: A0A452G088
names: Similarity
messages: Belongs to the C/M/P thioester hydrolase family.

9925:TSPAN31
gene id: 9925:TSPAN31
uniprot id: A0A452EN86
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9925:LOC102173562
gene id: 9925:LOC102173562
uniprot id: A0A452DQ46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the cytochrome c oxidase VIIc family.
messages: Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits. The complex is composed of a catalytic core of 3 subunits, encoded in the mitochondrial DNA, and 11 supernumerary subunits, which are encoded in the nuclear genome. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).
messages: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
messages: Membrane
messages: Mitochondrion inner membrane

9925:DLGAP1
gene id: 9925:DLGAP1
uniprot id: A0A452F312
names: Similarity
messages: Belongs to the SAPAP family.

9925:ALDH8A1
gene id: 9925:ALDH8A1
uniprot id: A0A452FSX2
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

9925:LBR
gene id: 9925:LBR
uniprot id: A0A452EHT5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ERG4/ERG24 family.
messages: Cytoplasm
messages: Endoplasmic reticulum membrane
messages: Membrane
messages: Nucleus inner membrane

9925:GTF2B
gene id: 9925:GTF2B
uniprot id: A0A452G5K0
names: Similarity
messages: Belongs to the TFIIB family.

9925:CHUK
gene id: 9925:CHUK
uniprot id: A0A452EYD5
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

9925:RAD54L2
gene id: 9925:RAD54L2
uniprot id: A0A452DYL9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SNF2/RAD54 helicase family.
messages: Nucleus

9925:TSPAN9
gene id: 9925:TSPAN9
uniprot id: A0A452EJN5
uniprot id: A0A452EJW2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tetraspanin (TM4SF) family.
messages: Membrane

9925:LOC102184973
gene id: 9925:LOC102184973
uniprot id: A0A452E8L2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the G-protein coupled receptor 1 family.
messages: Cell membrane
messages: Membrane
messages: Putative odorant or sperm cell receptor.

9925:LYVE1
gene id: 9925:LYVE1
uniprot id: A0A452G259
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

9925:USMG5
gene id: 9925:USMG5
uniprot id: A0A452DPJ0
names: Subcellular Location Annotation
messages: Membrane
messages: Mitochondrion membrane

9925:LOC108638229
gene id: 9925:LOC108638229
uniprot id: A0A452F680
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the somatotropin/prolactin family.
messages: Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
messages: Secreted

9925:KMT5C
gene id: 9925:KMT5C
uniprot id: A0A452E1L7
names: Subcellular Location Annotation
messages: Nucleus

9925:FAM210B
gene id: 9925:FAM210B
uniprot id: A0A452FCV5
names: Similarity
messages: Belongs to the FAM210 family.

9925:SYNGR2
gene id: 9925:SYNGR2
uniprot id: A0A452DWG5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the synaptogyrin family.
messages: Membrane

9925:SLC45A1
gene id: 9925:SLC45A1
uniprot id: A0A452G2W2
names: Subcellular Location Annotation
messages: Membrane

9925:LOC102185323
gene id: 9925:LOC102185323
uniprot id: A0A452E1V4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the histone H2B family.
messages: Nucleus
messages: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

9925:TSHR
gene id: 9925:TSHR
uniprot id: A0A452F6C1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Basolateral cell membrane
messages: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.
messages: Cell membrane
messages: Interacts with heterodimer GPHA2:GPHB5; this interaction stimulates cAMP production. Interacts (via the PDZ-binding motif) with SCRIB; regulates TSHR trafficking and function.
messages: Lateral cell membrane
messages: Membrane
messages: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.

9925:PLIN1
gene id: 9925:PLIN1
uniprot id: A0A452FW84
names: Similarity
messages: Belongs to the perilipin family.

9925:HOXA1
gene id: 9925:HOXA1
uniprot id: A0A452FUM2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Antp homeobox family. Labial subfamily.
messages: Nucleus

9925:PDZK1IP1
gene id: 9925:PDZK1IP1
uniprot id: A0A452E2H5
uniprot id: A0A8C2NJE5
names: Subcellular Location Annotation
messages: Membrane

9925:TMEM216
gene id: 9925:TMEM216
uniprot id: A0A8C2SA14
names: Subcellular Location Annotation
messages: Membrane

9925:PARP1
gene id: 9925:PARP1
uniprot id: A0A452F3M5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ARTD/PARP family.
messages: Chromosome
messages: Interacts (when auto-poly-ADP-ribosylated) with AIFM1.
messages: Nucleus
messages: Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.
messages: This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis.

9925:SORCS3
gene id: 9925:SORCS3
uniprot id: A0A452DQH6
names: Similarity
messages: Belongs to the VPS10-related sortilin family. SORCS subfamily.

9925:SERPINI2
gene id: 9925:SERPINI2
uniprot id: A0A452F5F2
names: Similarity
messages: Belongs to the serpin family.