28892:METLI RS06970
gene id: 28892:METLI_RS06970
uniprot id: J1L2U0
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

28892:METLI RS06265
gene id: 28892:METLI_RS06265
uniprot id: J0S052
names: Similarity
messages: Belongs to the UPF0215 family.

28892:METLI RS00420
gene id: 28892:METLI_RS00420
uniprot id: J0RX14
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

28892:METLI RS08145
gene id: 28892:METLI_RS08145
uniprot id: J0SA95
names: Similarity
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.

28892:METLI RS02745
gene id: 28892:METLI_RS02745
uniprot id: J0S7L2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS07880
gene id: 28892:METLI_RS07880
uniprot id: J1L470
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the aTrm56 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.

28892:METLI RS01690
gene id: 28892:METLI_RS01690
uniprot id: J1L106
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family.
messages: Cytoplasm
messages: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
messages: Heterodimer of two subunits, one of which binds GTP.

28892:METLI RS10270
gene id: 28892:METLI_RS10270
uniprot id: J0SBB5
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

28892:METLI RS04835
gene id: 28892:METLI_RS04835
uniprot id: J1APV5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

28892:METLI RS11255
gene id: 28892:METLI_RS11255
uniprot id: J1L4Z7
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS09210
gene id: 28892:METLI_RS09210
uniprot id: J1L3Y4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

28892:METLI RS08500
gene id: 28892:METLI_RS08500
uniprot id: J1L3J8
names: Cofactor
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

28892:METLI RS03630
gene id: 28892:METLI_RS03630
uniprot id: J0RYQ9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin subunit beta family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

28892:METLI RS00995
gene id: 28892:METLI_RS00995
uniprot id: J1AMW5
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS07570
gene id: 28892:METLI_RS07570
uniprot id: J1AR80
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS28 family.

28892:METLI RS02835
gene id: 28892:METLI_RS02835
uniprot id: J1L0M4
names: Cofactor
names: Similarity
messages: Belongs to the UPF0313 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

28892:METLI RS05380
gene id: 28892:METLI_RS05380
uniprot id: J0S8W7
names: Similarity
messages: Belongs to the class-I fumarase family.

28892:METLI RS02430
gene id: 28892:METLI_RS02430
uniprot id: J0S7F5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrE family.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

28892:METLI RS11975
gene id: 28892:METLI_RS11975
uniprot id: J0S384
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.
messages: Nucleus
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure.

28892:METLI RS04095
gene id: 28892:METLI_RS04095
uniprot id: J1L197
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6A family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

28892:METLI RS05895
gene id: 28892:METLI_RS05895
uniprot id: J1AQB3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the eIF-5A family.
messages: Cytoplasm
messages: Functions by promoting the formation of the first peptide bond.

28892:METLI RS02875
gene id: 28892:METLI_RS02875
uniprot id: J0S7N3
names: Function
names: Similarity
messages: Belongs to the group II decarboxylase family. MfnA subfamily.
messages: Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.

28892:METLI RS07730
gene id: 28892:METLI_RS07730
uniprot id: J0SA21
names: Similarity
messages: Belongs to the UPF0210 family.

28892:METLI RS03495
gene id: 28892:METLI_RS03495
uniprot id: J0S7Y4
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
messages: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.

28892:METLI RS00585
gene id: 28892:METLI_RS00585
uniprot id: J1L0F7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DNA polymerase delta/II small subunit family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

28892:METLI RS10070
gene id: 28892:METLI_RS10070
uniprot id: J0SB81
names: Similarity
messages: Belongs to the HsdR family.

28892:METLI RS00725
gene id: 28892:METLI_RS00725
uniprot id: J1AMR4
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
messages: Cytoplasm
messages: Homotetramer.

28892:METLI RS08995
gene id: 28892:METLI_RS08995
uniprot id: J0SAP6
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL21 family.

28892:METLI RS12015
gene id: 28892:METLI_RS12015
uniprot id: J0S391
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the THI4 family.
messages: Homooctamer; tetramer of dimers.
messages: Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS02110
gene id: 28892:METLI_RS02110
uniprot id: J1L190
names: Function
names: Similarity
messages: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
messages: Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.

28892:METLI RS01700
gene id: 28892:METLI_RS01700
uniprot id: J1L023
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the QueC family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).

28892:METLI RS08930
gene id: 28892:METLI_RS08930
uniprot id: J1L4Q0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 4 family.
messages: Binds 1 zinc ion per subunit.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

28892:METLI RS00755
gene id: 28892:METLI_RS00755
uniprot id: J0S6I1
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS04615
gene id: 28892:METLI_RS04615
uniprot id: J0S8J1
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

28892:METLI RS12020
gene id: 28892:METLI_RS12020
uniprot id: J1L5I5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M48B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

28892:METLI RS08615
gene id: 28892:METLI_RS08615
uniprot id: J0SAH7
names: Similarity
messages: Belongs to the UPF0147 family.

28892:METLI RS00605
gene id: 28892:METLI_RS00605
uniprot id: J0S6F3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

28892:METLI RS08365
gene id: 28892:METLI_RS08365
uniprot id: J0S181
names: Function
names: Similarity
messages: Acts on leucine, isoleucine and valine.
messages: Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.

28892:METLI RS11660
gene id: 28892:METLI_RS11660
uniprot id: J1AT65
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.
messages: Belongs to the TiaS family.
messages: Cytoplasm

28892:METLI RS06060
gene id: 28892:METLI_RS06060
uniprot id: J1AQE5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

28892:METLI RS08135
gene id: 28892:METLI_RS08135
uniprot id: J1L3D6
names: Function
names: Similarity
messages: Belongs to the GHMP kinase family. PoK subfamily.
messages: Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.

28892:METLI RS01940
gene id: 28892:METLI_RS01940
uniprot id: J0S775
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

28892:METLI RS11940
gene id: 28892:METLI_RS11940
uniprot id: J0SCA0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the STT3 family.
messages: Membrane

28892:METLI RS05840
gene id: 28892:METLI_RS05840
uniprot id: J1L270
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

28892:METLI RS06205
gene id: 28892:METLI_RS06205
uniprot id: J0S043
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

28892:METLI RS01680
gene id: 28892:METLI_RS01680
uniprot id: J1AN89
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TYW1 family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
messages: Cytoplasm
messages: Monomer.

28892:METLI RS00620
gene id: 28892:METLI_RS00620
uniprot id: J1KZE7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobD/CbiB family.
messages: Cell membrane
messages: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

28892:METLI RS07295
gene id: 28892:METLI_RS07295
uniprot id: J1L2Y5
names: Similarity
messages: Belongs to the carbamate kinase family.

28892:METLI RS02810
gene id: 28892:METLI_RS02810
uniprot id: J1L0M0
names: Function
names: Similarity
messages: Belongs to the ATP-dependent DNA ligase family.
messages: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

28892:METLI RS11185
gene id: 28892:METLI_RS11185
uniprot id: J0SBS2
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

28892:METLI RS04630
gene id: 28892:METLI_RS04630
uniprot id: J1L1L0
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

28892:METLI RS08690
gene id: 28892:METLI_RS08690
uniprot id: J0SAJ2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS09600
gene id: 28892:METLI_RS09600
uniprot id: J0S1Y9
names: Similarity
messages: Belongs to the UPF0179 family.

28892:METLI RS09480
gene id: 28892:METLI_RS09480
uniprot id: J1L460
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

28892:METLI RS00380
gene id: 28892:METLI_RS00380
uniprot id: J0S6A4
names: Similarity
messages: Belongs to the V-ATPase F subunit family.

28892:METLI RS06820
gene id: 28892:METLI_RS06820
uniprot id: J0S0I3
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS07380
gene id: 28892:METLI_RS07380
uniprot id: J0S9X0
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS05585
gene id: 28892:METLI_RS05585
uniprot id: J1L2Z3
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

28892:METLI RS02260
gene id: 28892:METLI_RS02260
uniprot id: J0S7C4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

28892:METLI RS09660
gene id: 28892:METLI_RS09660
uniprot id: J0SB21
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiN family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

28892:METLI RS02845
gene id: 28892:METLI_RS02845
uniprot id: J0S7N0
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS12335
gene id: 28892:METLI_RS12335
uniprot id: J1L172
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

28892:METLI RS02065
gene id: 28892:METLI_RS02065
uniprot id: J1L084
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS02685
gene id: 28892:METLI_RS02685
uniprot id: J1L0J7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

28892:METLI RS04380
gene id: 28892:METLI_RS04380
uniprot id: J1APN2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
messages: Cytoplasm
messages: Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.

28892:METLI RS12065
gene id: 28892:METLI_RS12065
uniprot id: J0SCB8
names: Similarity
messages: In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.
messages: In the central section; belongs to the CRISPR-associated helicase Cas3 family.

28892:METLI RS11535
gene id: 28892:METLI_RS11535
uniprot id: J1AT43
names: Cofactor
messages: Binds 2 irons ions per subunit via 4 cysteine residues per iron.

28892:METLI RS03245
gene id: 28892:METLI_RS03245
uniprot id: J0RYI9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

28892:METLI RS04505
gene id: 28892:METLI_RS04505
uniprot id: J1L1J3
names: Similarity
messages: Belongs to the HupF/HypC family.

28892:METLI RS07585
gene id: 28892:METLI_RS07585
uniprot id: J0S0V3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0056 (MarC) family.
messages: Cell membrane
messages: Membrane

28892:METLI RS03305
gene id: 28892:METLI_RS03305
uniprot id: J1L0V2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

28892:METLI RS11055
gene id: 28892:METLI_RS11055
uniprot id: J0S2M3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the thiamine-phosphate synthase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).

28892:METLI RS02440
gene id: 28892:METLI_RS02440
uniprot id: J1L0F2
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

28892:METLI RS08765
gene id: 28892:METLI_RS08765
uniprot id: J1L3P2
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS09695
gene id: 28892:METLI_RS09695
uniprot id: J0S203
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase HII family.
messages: Cytoplasm
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

28892:METLI RS10215
gene id: 28892:METLI_RS10215
uniprot id: J1L4G9
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS02235
gene id: 28892:METLI_RS02235
uniprot id: J0S7B9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: Located at the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

28892:METLI RS09010
gene id: 28892:METLI_RS09010
uniprot id: J1L3U0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

28892:METLI RS04550
gene id: 28892:METLI_RS04550
uniprot id: J0RZB8
names: Caution
names: Function
names: Similarity
messages: Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.
messages: Catalyzes the NAD(+)-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS03605
gene id: 28892:METLI_RS03605
uniprot id: J1L1Z0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1A family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

28892:METLI RS07505
gene id: 28892:METLI_RS07505
uniprot id: J1L420
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CobS family.
messages: Cell membrane
messages: Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
messages: Membrane

28892:METLI RS07145
gene id: 28892:METLI_RS07145
uniprot id: J1AR10
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS02485
gene id: 28892:METLI_RS02485
uniprot id: J0RY66
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

28892:METLI RS07910
gene id: 28892:METLI_RS07910
uniprot id: J0S104
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

28892:METLI RS03055
gene id: 28892:METLI_RS03055
uniprot id: J0S7R1
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

28892:METLI RS01005
gene id: 28892:METLI_RS01005
uniprot id: J1L0N7
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS07495
gene id: 28892:METLI_RS07495
uniprot id: J1AR68
names: Similarity
messages: Belongs to the UPF0284 family.

28892:METLI RS04430
gene id: 28892:METLI_RS04430
uniprot id: J1APP0
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Homodimer.

28892:METLI RS05730
gene id: 28892:METLI_RS05730
uniprot id: J0S935
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GGGP/HepGP synthase family. Group I subfamily.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

28892:METLI RS09305
gene id: 28892:METLI_RS09305
uniprot id: J1L431
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
messages: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
messages: Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.
messages: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.

28892:METLI RS03050
gene id: 28892:METLI_RS03050
uniprot id: J1ANW1
names: Similarity
messages: Belongs to the MEMO1 family.

28892:METLI RS03790
gene id: 28892:METLI_RS03790
uniprot id: J0S838
names: Similarity
messages: Belongs to the UPF0175 family.

28892:METLI RS10890
gene id: 28892:METLI_RS10890
uniprot id: J1L4T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

28892:METLI RS06070
gene id: 28892:METLI_RS06070
uniprot id: J1L391
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

28892:METLI RS09735
gene id: 28892:METLI_RS09735
uniprot id: J1AS95
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS06915
gene id: 28892:METLI_RS06915
uniprot id: J0S0J6
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

28892:METLI RS07575
gene id: 28892:METLI_RS07575
uniprot id: J0S9Z9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL24 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.

28892:METLI RS07725
gene id: 28892:METLI_RS07725
uniprot id: J1ARA3
names: Similarity
messages: Belongs to the UPF0237 family.

28892:METLI RS02170
gene id: 28892:METLI_RS02170
uniprot id: J0RY20
names: Function
names: Similarity
messages: Belongs to the MTD family.
messages: Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.

28892:METLI RS00580
gene id: 28892:METLI_RS00580
uniprot id: J0S6E8
names: Similarity
messages: Belongs to the DtxR/MntR family.

28892:METLI RS02005
gene id: 28892:METLI_RS02005
uniprot id: J0RXZ6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS10895
gene id: 28892:METLI_RS10895
uniprot id: J1ASU2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

28892:METLI RS08845
gene id: 28892:METLI_RS08845
uniprot id: J1ARS0
names: Similarity
messages: Belongs to the SUI1 family.

28892:METLI RS03555
gene id: 28892:METLI_RS03555
uniprot id: J1L1Y1
names: Similarity
names: Subunit
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
messages: Heterooligomer of catalytic and regulatory chains.

28892:METLI RS00485
gene id: 28892:METLI_RS00485
uniprot id: J1L0D8
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

28892:METLI RS01390
gene id: 28892:METLI_RS01390
uniprot id: J1L0V1
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS02350
gene id: 28892:METLI_RS02350
uniprot id: J1L0D1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the LemA family.
messages: Membrane

28892:METLI RS07490
gene id: 28892:METLI_RS07490
uniprot id: J1L324
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).

28892:METLI RS00150
gene id: 28892:METLI_RS00150
uniprot id: J1AMG8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

28892:METLI RS03280
gene id: 28892:METLI_RS03280
uniprot id: J1ANZ4
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

28892:METLI RS02945
gene id: 28892:METLI_RS02945
uniprot id: J1ANV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.

28892:METLI RS02690
gene id: 28892:METLI_RS02690
uniprot id: J1ANR2
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

28892:METLI RS05900
gene id: 28892:METLI_RS05900
uniprot id: J1L358
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS10540
gene id: 28892:METLI_RS10540
uniprot id: J1L4M7
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

28892:METLI RS11455
gene id: 28892:METLI_RS11455
uniprot id: J1L606
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

28892:METLI RS04700
gene id: 28892:METLI_RS04700
uniprot id: J0RZE1
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

28892:METLI RS11235
gene id: 28892:METLI_RS11235
uniprot id: J1ASZ8
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS05665
gene id: 28892:METLI_RS05665
uniprot id: J0RZU0
names: Function
messages: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

28892:METLI RS02095
gene id: 28892:METLI_RS02095
uniprot id: J1L086
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
messages: Cytoplasm
messages: May catalyze the biosynthesis of dTMP using an unknown cosubstrate.
messages: Monomer.

28892:METLI RS05995
gene id: 28892:METLI_RS05995
uniprot id: J1L376
names: Subcellular Location Annotation
messages: Cytoplasm

28892:METLI RS05370
gene id: 28892:METLI_RS05370
uniprot id: J1L1Y6
names: Similarity
messages: Belongs to the universal ribosomal protein uL16 family.

28892:METLI RS09760
gene id: 28892:METLI_RS09760
uniprot id: J1L498
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

28892:METLI RS09065
gene id: 28892:METLI_RS09065
uniprot id: J1ARV7
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the LeuD family. LeuD type 2 subfamily.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS00700
gene id: 28892:METLI_RS00700
uniprot id: J1AMQ9
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS09535
gene id: 28892:METLI_RS09535
uniprot id: J1AS60
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

28892:METLI RS09325
gene id: 28892:METLI_RS09325
uniprot id: J0S1U3
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

28892:METLI RS11850
gene id: 28892:METLI_RS11850
uniprot id: J0S363
names: Similarity
messages: Belongs to the HAD-like hydrolase superfamily.

28892:METLI RS02915
gene id: 28892:METLI_RS02915
uniprot id: J1L0N8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PurS family.
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

28892:METLI RS07530
gene id: 28892:METLI_RS07530
uniprot id: J1L422
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS00395
gene id: 28892:METLI_RS00395
uniprot id: J1KZA4
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

28892:METLI RS04975
gene id: 28892:METLI_RS04975
uniprot id: J1L1R9
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase T1B family.
messages: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
messages: Cytoplasm
messages: The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.
messages: The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.

28892:METLI RS05500
gene id: 28892:METLI_RS05500
uniprot id: J1AQ56
names: Similarity
messages: Belongs to the MtxX family.

28892:METLI RS00335
gene id: 28892:METLI_RS00335
uniprot id: J1L0A6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the anthranilate phosphoribosyltransferase family.
messages: Binds 2 magnesium ions per monomer.
messages: Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS07455
gene id: 28892:METLI_RS07455
uniprot id: J1L412
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

28892:METLI RS01255
gene id: 28892:METLI_RS01255
uniprot id: J0S6R0
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS09520
gene id: 28892:METLI_RS09520
uniprot id: J1L539
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

28892:METLI RS02290
gene id: 28892:METLI_RS02290
uniprot id: J1L1B9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

28892:METLI RS04665
gene id: 28892:METLI_RS04665
uniprot id: J0S8J8
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

28892:METLI RS09800
gene id: 28892:METLI_RS09800
uniprot id: J1ASA4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

28892:METLI RS08565
gene id: 28892:METLI_RS08565
uniprot id: J1ARM7
names: Function
names: Similarity
messages: Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10-methylenetetrahydromethanopterin.
messages: Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
messages: In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
messages: In the N-terminal section; belongs to the formaldehyde-activating enzyme family.

28892:METLI RS03220
gene id: 28892:METLI_RS03220
uniprot id: J0RYI5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the diphthine synthase family.
messages: Homodimer.
messages: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.

28892:METLI RS02075
gene id: 28892:METLI_RS02075
uniprot id: J0S793
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyltransferase superfamily. Fibrillarin family.
messages: Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.
messages: Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.

28892:METLI RS04575
gene id: 28892:METLI_RS04575
uniprot id: J0RZC1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

28892:METLI RS10440
gene id: 28892:METLI_RS10440
uniprot id: J1L4K7
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS11770
gene id: 28892:METLI_RS11770
uniprot id: J1L663
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS11160
gene id: 28892:METLI_RS11160
uniprot id: J0SBR5
names: Similarity
messages: Belongs to the UPF0111 family.

28892:METLI RS07280
gene id: 28892:METLI_RS07280
uniprot id: J0S9V3
names: Similarity
messages: Belongs to the acylphosphatase family.

28892:METLI RS09525
gene id: 28892:METLI_RS09525
uniprot id: J0S1X5
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS09320
gene id: 28892:METLI_RS09320
uniprot id: J1L505
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

28892:METLI RS10290
gene id: 28892:METLI_RS10290
uniprot id: J1ASI9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS10665
gene id: 28892:METLI_RS10665
uniprot id: J0S2F1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein P1/P2 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

28892:METLI RS01250
gene id: 28892:METLI_RS01250
uniprot id: J1AN07
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

28892:METLI RS03580
gene id: 28892:METLI_RS03580
uniprot id: J1L1Y4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Belongs to the NnrE/AIBP family.
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
messages: Homotetramer.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS08960
gene id: 28892:METLI_RS08960
uniprot id: J1L3S9
names: Function
names: Similarity
messages: Belongs to the eIF-6 family.
messages: Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.

28892:METLI RS11505
gene id: 28892:METLI_RS11505
uniprot id: J1L549
names: Subcellular Location Annotation
messages: Cytoplasm

28892:METLI RS10295
gene id: 28892:METLI_RS10295
uniprot id: J0SBC0
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS03030
gene id: 28892:METLI_RS03030
uniprot id: J0S7Q6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
messages: Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.
messages: Cytoplasm
messages: Homodimer.

28892:METLI RS03185
gene id: 28892:METLI_RS03185
uniprot id: J0S7T2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS09350
gene id: 28892:METLI_RS09350
uniprot id: J0S1U7
names: Similarity
messages: Belongs to the peptidase C56 family.

28892:METLI RS01160
gene id: 28892:METLI_RS01160
uniprot id: J1L0R1
names: Similarity
messages: In the C-terminal section; belongs to the transposase 35 family.
messages: In the N-terminal section; belongs to the transposase 2 family.

28892:METLI RS02455
gene id: 28892:METLI_RS02455
uniprot id: J1L1E2
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

28892:METLI RS03545
gene id: 28892:METLI_RS03545
uniprot id: J1AP38
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

28892:METLI RS04045
gene id: 28892:METLI_RS04045
uniprot id: J1APE1
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS09615
gene id: 28892:METLI_RS09615
uniprot id: J0SB14
names: Cofactor
names: Similarity
messages: Belongs to the ELP3 family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

28892:METLI RS08725
gene id: 28892:METLI_RS08725
uniprot id: J1L4L2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.

28892:METLI RS04670
gene id: 28892:METLI_RS04670
uniprot id: J1L2L5
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

28892:METLI RS03780
gene id: 28892:METLI_RS03780
uniprot id: J1L134
names: Similarity
messages: Belongs to the archaeal-type GPI family.

28892:METLI RS04725
gene id: 28892:METLI_RS04725
uniprot id: J0RZE5
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS01885
gene id: 28892:METLI_RS01885
uniprot id: J1ANE7
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.
messages: Belongs to the RuBisCO large chain family. Type III subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.
messages: Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits.

28892:METLI RS05810
gene id: 28892:METLI_RS05810
uniprot id: J0RZW8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

28892:METLI RS10475
gene id: 28892:METLI_RS10475
uniprot id: J0SBF1
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

28892:METLI RS06135
gene id: 28892:METLI_RS06135
uniprot id: J1AQF9
names: Function
names: Similarity
messages: Belongs to the CheD family.
messages: Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.

28892:METLI RS04455
gene id: 28892:METLI_RS04455
uniprot id: J1APP4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

28892:METLI RS09380
gene id: 28892:METLI_RS09380
uniprot id: J1L444
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

28892:METLI RS07405
gene id: 28892:METLI_RS07405
uniprot id: J0S9X4
names: Similarity
messages: Belongs to the Mg-chelatase subunits D/I family.

28892:METLI RS01765
gene id: 28892:METLI_RS01765
uniprot id: J1L139
names: Caution
names: Function
names: Similarity
messages: Belongs to the UbiX/PAD1 family.
messages: Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS04635
gene id: 28892:METLI_RS04635
uniprot id: J1APS4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IlvD/Edd family.
messages: Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.
messages: Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS12525
gene id: 28892:METLI_RS12525
uniprot id: J0SBD5
names: Similarity
messages: Belongs to the peptidase C1 family.

28892:METLI RS05625
gene id: 28892:METLI_RS05625
uniprot id: J0S916
names: Cofactor
names: Function
names: Subunit
messages: Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

28892:METLI RS13295
gene id: 28892:METLI_RS13295
uniprot id: J1L0C0
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

28892:METLI RS02770
gene id: 28892:METLI_RS02770
uniprot id: J0S7L6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS06275
gene id: 28892:METLI_RS06275
uniprot id: J1AQH6
names: Subunit
messages: Homotetramer.

28892:METLI RS05560
gene id: 28892:METLI_RS05560
uniprot id: J1L2Y9
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the L-aspartate dehydrogenase family.
messages: Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
messages: The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.

28892:METLI RS03590
gene id: 28892:METLI_RS03590
uniprot id: J1L100
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL15 family.

28892:METLI RS10975
gene id: 28892:METLI_RS10975
uniprot id: J1L5R4
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS1 family.

28892:METLI RS06645
gene id: 28892:METLI_RS06645
uniprot id: J1AQQ0
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

28892:METLI RS07210
gene id: 28892:METLI_RS07210
uniprot id: J0S0P4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

28892:METLI RS03315
gene id: 28892:METLI_RS03315
uniprot id: J0S7V4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

28892:METLI RS08520
gene id: 28892:METLI_RS08520
uniprot id: J1L4H5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane
messages: Potential transporter for phosphate.

28892:METLI RS11985
gene id: 28892:METLI_RS11985
uniprot id: J1ATC7
names: Function
names: Similarity
messages: Belongs to the GTP-dependent DPCK family.
messages: Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).

28892:METLI RS09000
gene id: 28892:METLI_RS09000
uniprot id: J1L4R5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.
messages: Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.

28892:METLI RS07435
gene id: 28892:METLI_RS07435
uniprot id: J0S0S9
names: Function
names: Similarity
messages: Belongs to the CbiD family.
messages: Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.

28892:METLI RS11475
gene id: 28892:METLI_RS11475
uniprot id: J1L610
names: Similarity
messages: Belongs to the ZPR1 family.

28892:METLI RS03525
gene id: 28892:METLI_RS03525
uniprot id: J0S7Y9
names: Function
names: Similarity
messages: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
messages: Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).

28892:METLI RS08130
gene id: 28892:METLI_RS08130
uniprot id: J0S146
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS10005
gene id: 28892:METLI_RS10005
uniprot id: J1L4D8
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

28892:METLI RS04510
gene id: 28892:METLI_RS04510
uniprot id: J1APQ2
names: Function
names: Similarity
messages: Belongs to the HypA/HybF family.
messages: Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.

28892:METLI RS00615
gene id: 28892:METLI_RS00615
uniprot id: J0RX54
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PdxS/SNZ family.
messages: Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.
messages: In the presence of PdxT, forms a dodecamer of heterodimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS03115
gene id: 28892:METLI_RS03115
uniprot id: J1L1P2
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

28892:METLI RS06340
gene id: 28892:METLI_RS06340
uniprot id: J0S066
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BioY family.
messages: Cell membrane

28892:METLI RS01225
gene id: 28892:METLI_RS01225
uniprot id: J1AN02
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.
messages: Binds 2 magnesium ions per subunit.
messages: Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS03020
gene id: 28892:METLI_RS03020
uniprot id: J1L0Q1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm

28892:METLI RS07525
gene id: 28892:METLI_RS07525
uniprot id: J0S9Z3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

28892:METLI RS10175
gene id: 28892:METLI_RS10175
uniprot id: J0SB97
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

28892:METLI RS07020
gene id: 28892:METLI_RS07020
uniprot id: J1AQZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

28892:METLI RS08945
gene id: 28892:METLI_RS08945
uniprot id: J1ART6
names: Similarity
messages: Belongs to the PDCD5 family.

28892:METLI RS02760
gene id: 28892:METLI_RS02760
uniprot id: J1L0L0
names: Similarity
messages: Belongs to the tRNA methyltransferase O family.

28892:METLI RS09225
gene id: 28892:METLI_RS09225
uniprot id: J1L4W0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TspO/BZRP family.
messages: Membrane

28892:METLI RS03195
gene id: 28892:METLI_RS03195
uniprot id: J0RYH9
names: Subcellular Location Annotation
messages: Cytoplasm
messages: Nucleus

28892:METLI RS03905
gene id: 28892:METLI_RS03905
uniprot id: J0S854
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvB family.
messages: Cytoplasm
messages: Has 3 domains, the large (RuvB-L) and small ATPase (RuvB-S) domains and the C-terminal head (RuvB-H) domain. The head domain binds DNA, while the ATPase domains jointly bind ATP, ADP or are empty depending on the state of the subunit in the translocation cycle. During a single DNA translocation step the structure of each domain remains the same, but their relative positions change.
messages: Homohexamer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. RuvB forms 2 homohexamers on either side of HJ DNA bound by 1 or 2 RuvA tetramers; 4 subunits per hexamer contact DNA at a time. Coordinated motions by a converter formed by DNA-disengaged RuvB subunits stimulates ATP hydrolysis and nucleotide exchange. Immobilization of the converter enables RuvB to convert the ATP-contained energy into a lever motion, pulling 2 nucleotides of DNA out of the RuvA tetramer per ATP hydrolyzed, thus driving DNA branch migration. The RuvB motors rotate together with the DNA substrate, which together with the progressing nucleotide cycle form the mechanistic basis for DNA recombination by continuous HJ branch migration. Branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves cruciform DNA.

28892:METLI RS02195
gene id: 28892:METLI_RS02195
uniprot id: J0RY23
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

28892:METLI RS09085
gene id: 28892:METLI_RS09085
uniprot id: J1L3V5
names: Similarity
messages: Belongs to the bacterial solute-binding protein 1 family. WtpA subfamily.

28892:METLI RS02565
gene id: 28892:METLI_RS02565
uniprot id: J1ANP3
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS00470
gene id: 28892:METLI_RS00470
uniprot id: J1KZC0
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS05535
gene id: 28892:METLI_RS05535
uniprot id: J1L2Y4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

28892:METLI RS00775
gene id: 28892:METLI_RS00775
uniprot id: J1AMS5
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

28892:METLI RS03060
gene id: 28892:METLI_RS03060
uniprot id: J1L1N3
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

28892:METLI RS07220
gene id: 28892:METLI_RS07220
uniprot id: J1AR21
names: Similarity
messages: Belongs to the MCM family.

28892:METLI RS10660
gene id: 28892:METLI_RS10660
uniprot id: J1L5K9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.

28892:METLI RS08325
gene id: 28892:METLI_RS08325
uniprot id: J1ARJ8
names: Similarity
messages: Belongs to the UPF0145 family.

28892:METLI RS08990
gene id: 28892:METLI_RS08990
uniprot id: J1ARU5
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase Pus10 family.
messages: Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.

28892:METLI RS09670
gene id: 28892:METLI_RS09670
uniprot id: J0S200
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC transporter superfamily.
messages: Cell membrane
messages: Membrane
messages: Part of an ABC transporter complex. Responsible for energy coupling to the transport system.
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

28892:METLI RS02010
gene id: 28892:METLI_RS02010
uniprot id: J1L076
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0316 family.
messages: Cell membrane
messages: Membrane

28892:METLI RS10350
gene id: 28892:METLI_RS10350
uniprot id: J1L5G0
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the thiamine-monophosphate kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.

28892:METLI RS08410
gene id: 28892:METLI_RS08410
uniprot id: J0SAE5
names: Similarity
messages: Belongs to the Ahb/Nir family.

28892:METLI RS02190
gene id: 28892:METLI_RS02190
uniprot id: J1L1A3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29.

28892:METLI RS05415
gene id: 28892:METLI_RS05415
uniprot id: J0RZP8
names: Function
names: Similarity
messages: Belongs to the adenylate cyclase family. DacZ subfamily.
messages: Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.

28892:METLI RS03365
gene id: 28892:METLI_RS03365
uniprot id: J0S7W2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Dps family.
messages: Homododecamer. The 12 identical subunits form a hollow sphere into which the mineral iron core of up to 300 Fe(3+) can be deposited.
messages: Protects DNA from oxidative damage by sequestering intracellular Fe2+ ion and storing it in the form of Fe3+ oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe2+ ions, which prevents hydroxyl radical production by the Fenton reaction.
messages: nucleoid

28892:METLI RS03770
gene id: 28892:METLI_RS03770
uniprot id: J1L226
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS04885
gene id: 28892:METLI_RS04885
uniprot id: J1APW2
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS08665
gene id: 28892:METLI_RS08665
uniprot id: J0SAI7
names: Similarity
names: Subunit
messages: Belongs to the HTP reductase family.
messages: Homodimer.

28892:METLI RS10755
gene id: 28892:METLI_RS10755
uniprot id: J1L5M4
names: Similarity
messages: Belongs to the glutamate synthase family.

28892:METLI RS02185
gene id: 28892:METLI_RS02185
uniprot id: J0S7B0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

28892:METLI RS10705
gene id: 28892:METLI_RS10705
uniprot id: J1L5L6
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

28892:METLI RS09215
gene id: 28892:METLI_RS09215
uniprot id: J1ARY3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

28892:METLI RS04755
gene id: 28892:METLI_RS04755
uniprot id: J1L1M8
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS00720
gene id: 28892:METLI_RS00720
uniprot id: J1KZG6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

28892:METLI RS06120
gene id: 28892:METLI_RS06120
uniprot id: J1L3A1
names: Domain
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CheB family.
messages: Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.
messages: Cytoplasm
messages: Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
messages: Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.

28892:METLI RS09620
gene id: 28892:METLI_RS09620
uniprot id: J1L555
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase small subunit family.
messages: Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

28892:METLI RS07190
gene id: 28892:METLI_RS07190
uniprot id: J1L2X0
names: Similarity
messages: Belongs to the PurH family.

28892:METLI RS10260
gene id: 28892:METLI_RS10260
uniprot id: J1L4H6
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

28892:METLI RS10250
gene id: 28892:METLI_RS10250
uniprot id: J1L5E5
names: Function
names: Similarity
messages: Belongs to the V-ATPase F subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

28892:METLI RS13045
gene id: 28892:METLI_RS13045
uniprot id: J1L1J9
names: Function
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

28892:METLI RS10910
gene id: 28892:METLI_RS10910
uniprot id: J1L4T9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS03035
gene id: 28892:METLI_RS03035
uniprot id: J1L1M6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IPP isomerase type 2 family.
messages: Cytoplasm
messages: Homooctamer. Dimer of tetramers.
messages: Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS05365
gene id: 28892:METLI_RS05365
uniprot id: J0RZP0
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS11825
gene id: 28892:METLI_RS11825
uniprot id: J0S358
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS00360
gene id: 28892:METLI_RS00360
uniprot id: J1L0B2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

28892:METLI RS00925
gene id: 28892:METLI_RS00925
uniprot id: J1L0M3
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

28892:METLI RS10640
gene id: 28892:METLI_RS10640
uniprot id: J0S2E8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecE/SEC61-gamma family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
messages: Membrane

28892:METLI RS02285
gene id: 28892:METLI_RS02285
uniprot id: J0S7C9
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

28892:METLI RS03310
gene id: 28892:METLI_RS03310
uniprot id: J1ANZ8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS02415
gene id: 28892:METLI_RS02415
uniprot id: J0RY55
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrB family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

28892:METLI RS01240
gene id: 28892:METLI_RS01240
uniprot id: J0RXF9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eIF-2-beta/eIF-5 family.
messages: Heterotrimer composed of an alpha, a beta and a gamma chain.
messages: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.

28892:METLI RS10390
gene id: 28892:METLI_RS10390
uniprot id: J1ASK5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SRP19 family.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

28892:METLI RS07935
gene id: 28892:METLI_RS07935
uniprot id: J0S109
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.

28892:METLI RS07755
gene id: 28892:METLI_RS07755
uniprot id: J0SA26
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.

28892:METLI RS09495
gene id: 28892:METLI_RS09495
uniprot id: J1L535
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

28892:METLI RS03895
gene id: 28892:METLI_RS03895
uniprot id: J1L158
names: Similarity
messages: Belongs to the RuvC family.

28892:METLI RS06065
gene id: 28892:METLI_RS06065
uniprot id: J0S9A0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Archaeal flagellum
messages: Belongs to the archaeal flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.

28892:METLI RS10795
gene id: 28892:METLI_RS10795
uniprot id: J1ASS3
names: Similarity
messages: Belongs to the glutamate synthase family.

28892:METLI RS00610
gene id: 28892:METLI_RS00610
uniprot id: J1L0G2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the glutaminase PdxT/SNO family.
messages: Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
messages: In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

28892:METLI RS08975
gene id: 28892:METLI_RS08975
uniprot id: J1L4Q9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

28892:METLI RS07385
gene id: 28892:METLI_RS07385
uniprot id: J1L403
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS04785
gene id: 28892:METLI_RS04785
uniprot id: J1APU7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS03565
gene id: 28892:METLI_RS03565
uniprot id: J1L0Z5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAC-alpha family.
messages: Contacts the emerging nascent chain on the ribosome.
messages: Homodimer. Interacts with the ribosome. Binds ribosomal RNA.

28892:METLI RS05885
gene id: 28892:METLI_RS05885
uniprot id: J0RZY1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS05315
gene id: 28892:METLI_RS05315
uniprot id: J0RZN1
names: Similarity
messages: Belongs to the UPF0212 family.

28892:METLI RS01220
gene id: 28892:METLI_RS01220
uniprot id: J1KZP7
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase IV family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
messages: Homodimer.

28892:METLI RS02495
gene id: 28892:METLI_RS02495
uniprot id: J1ANN3
names: Similarity
messages: Belongs to the HdrC family.

28892:METLI RS10380
gene id: 28892:METLI_RS10380
uniprot id: J1L5G5
names: Function
names: Similarity
messages: Belongs to the TFIIB family.
messages: Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

28892:METLI RS03025
gene id: 28892:METLI_RS03025
uniprot id: J1ANV7
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

28892:METLI RS09555
gene id: 28892:METLI_RS09555
uniprot id: J1L469
names: Function
names: Similarity
messages: Belongs to the MsrA Met sulfoxide reductase family.
messages: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.

28892:METLI RS04180
gene id: 28892:METLI_RS04180
uniprot id: J0S8A7
names: Similarity
messages: Belongs to the thymidylate kinase family.

28892:METLI RS04185
gene id: 28892:METLI_RS04185
uniprot id: J1L2B7
names: Similarity
messages: Belongs to the HisA/HisF family.

28892:METLI RS06300
gene id: 28892:METLI_RS06300
uniprot id: J1AQH9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecD.

28892:METLI RS00350
gene id: 28892:METLI_RS00350
uniprot id: J1AMK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

28892:METLI RS11925
gene id: 28892:METLI_RS11925
uniprot id: J0S376
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

28892:METLI RS02180
gene id: 28892:METLI_RS02180
uniprot id: J1ANI9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.

28892:METLI RS06710
gene id: 28892:METLI_RS06710
uniprot id: J1L3L9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS10420
gene id: 28892:METLI_RS10420
uniprot id: J0SBE5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS6 family.

28892:METLI RS09310
gene id: 28892:METLI_RS09310
uniprot id: J1AS22
names: Similarity
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

28892:METLI RS02245
gene id: 28892:METLI_RS02245
uniprot id: J0RY29
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

28892:METLI RS03915
gene id: 28892:METLI_RS03915
uniprot id: J1L163
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS04605
gene id: 28892:METLI_RS04605
uniprot id: J1L1K7
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS00495
gene id: 28892:METLI_RS00495
uniprot id: J1KZC5
names: Similarity
messages: Belongs to the DMRL synthase family.

28892:METLI RS01725
gene id: 28892:METLI_RS01725
uniprot id: J1L025
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

28892:METLI RS12395
gene id: 28892:METLI_RS12395
uniprot id: J0RZW2
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS11520
gene id: 28892:METLI_RS11520
uniprot id: J1L619
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS06715
gene id: 28892:METLI_RS06715
uniprot id: J0S0G9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Membrane

28892:METLI RS00635
gene id: 28892:METLI_RS00635
uniprot id: J1L0G8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

28892:METLI RS09270
gene id: 28892:METLI_RS09270
uniprot id: J0SAV3
names: Function
names: Similarity
messages: Belongs to the eukaryotic RecA-like protein family.
messages: Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.

28892:METLI RS04165
gene id: 28892:METLI_RS04165
uniprot id: J0RZ19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM19 family.
messages: Membrane

28892:METLI RS10865
gene id: 28892:METLI_RS10865
uniprot id: J1L4S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.
messages: Membrane

28892:METLI RS10100
gene id: 28892:METLI_RS10100
uniprot id: J0SB86
names: Similarity
messages: Belongs to the TBP family.

28892:METLI RS09455
gene id: 28892:METLI_RS09455
uniprot id: J1L456
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS08980
gene id: 28892:METLI_RS08980
uniprot id: J0S1J3
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.

28892:METLI RS01180
gene id: 28892:METLI_RS01180
uniprot id: J0S6Q2
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS04610
gene id: 28892:METLI_RS04610
uniprot id: J1APR9
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS08360
gene id: 28892:METLI_RS08360
uniprot id: J1L4F4
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

28892:METLI RS04325
gene id: 28892:METLI_RS04325
uniprot id: J1APM5
names: Similarity
names: Subunit
messages: Belongs to the FBP aldolase/phosphatase family.
messages: Homooctamer; dimer of tetramers.

28892:METLI RS04315
gene id: 28892:METLI_RS04315
uniprot id: J0RZ82
names: Similarity
messages: Belongs to the DeoC/FbaB aldolase family.

28892:METLI RS00180
gene id: 28892:METLI_RS00180
uniprot id: J0S666
names: Function
names: Similarity
names: Subunit
messages: Belongs to the threonine synthase family. Cysteate synthase subfamily.
messages: Homotrimer.
messages: Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate.

28892:METLI RS11355
gene id: 28892:METLI_RS11355
uniprot id: J1L5Y4
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS05120
gene id: 28892:METLI_RS05120
uniprot id: J0S8S2
names: Subcellular Location Annotation
messages: Cell membrane

28892:METLI RS03595
gene id: 28892:METLI_RS03595
uniprot id: J1AP46
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

28892:METLI RS02865
gene id: 28892:METLI_RS02865
uniprot id: J1L0M7
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

28892:METLI RS04740
gene id: 28892:METLI_RS04740
uniprot id: J0S8K8
names: Similarity
messages: Belongs to the complex I 20 kDa subunit family.

28892:METLI RS04375
gene id: 28892:METLI_RS04375
uniprot id: J1L1H4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS12245
gene id: 28892:METLI_RS12245
uniprot id: J1KZ59
names: Similarity
messages: Belongs to the methyl-accepting chemotaxis (MCP) protein family.

28892:METLI RS01210
gene id: 28892:METLI_RS01210
uniprot id: J1L0R9
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

28892:METLI RS07775
gene id: 28892:METLI_RS07775
uniprot id: J1ARB2
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS10180
gene id: 28892:METLI_RS10180
uniprot id: J1L5D4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.
messages: Belongs to the peptidase S16 family. Archaeal LonB subfamily.
messages: Cell membrane
messages: Homohexamer. Organized in a ring with a central cavity.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

28892:METLI RS07550
gene id: 28892:METLI_RS07550
uniprot id: J0S9Z6
names: Similarity
messages: Belongs to the glycosyltransferase 2 family.

28892:METLI RS08400
gene id: 28892:METLI_RS08400
uniprot id: J1L3I3
names: Similarity
messages: Belongs to the catalase family.

28892:METLI RS02965
gene id: 28892:METLI_RS02965
uniprot id: J0RYE2
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SMC family.
messages: Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.
messages: Cytoplasm
messages: Homodimer.
messages: Required for chromosome condensation and partitioning.

28892:METLI RS11305
gene id: 28892:METLI_RS11305
uniprot id: J1L508
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Binds 1 Fe(3+) ion per subunit.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

28892:METLI RS00565
gene id: 28892:METLI_RS00565
uniprot id: J0RX43
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Membrane

28892:METLI RS04100
gene id: 28892:METLI_RS04100
uniprot id: J1APF6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TOP6B family.
messages: Homodimer. Heterotetramer of two Top6A and two Top6B chains.
messages: Relaxes both positive and negative superturns and exhibits a strong decatenase activity.

28892:METLI RS01890
gene id: 28892:METLI_RS01890
uniprot id: J0S767
names: Caution
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the eIF-2B alpha/beta/delta subunits family. R15P isomerase subfamily.
messages: Catalyzes the isomerization of ribose 1,5-bisphosphate (R15P) to ribulose 1,5-bisphosphate (RuBP), the CO(2) acceptor and substrate for RubisCO. Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and RubisCO.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds via a cis-phosphoenolate intermediate.

28892:METLI RS07175
gene id: 28892:METLI_RS07175
uniprot id: J0S9T7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.
messages: Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
messages: Homodimer.

28892:METLI RS02880
gene id: 28892:METLI_RS02880
uniprot id: J1L1K3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
messages: Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

28892:METLI RS00320
gene id: 28892:METLI_RS00320
uniprot id: J1KZ91
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpB family.
messages: Tetramer of two alpha and two beta chains.
messages: The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.

28892:METLI RS11615
gene id: 28892:METLI_RS11615
uniprot id: J0SC13
names: Function
names: Similarity
messages: Belongs to the archaeal-type DHQ synthase family.
messages: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.

28892:METLI RS10300
gene id: 28892:METLI_RS10300
uniprot id: J1L5F2
names: Subcellular Location Annotation
messages: Cytoplasm

28892:METLI RS05965
gene id: 28892:METLI_RS05965
uniprot id: J0S980
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

28892:METLI RS08470
gene id: 28892:METLI_RS08470
uniprot id: J1L4G6
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase gamma subunit family.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

28892:METLI RS12205
gene id: 28892:METLI_RS12205
uniprot id: J0S3C1
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS11335
gene id: 28892:METLI_RS11335
uniprot id: J0S2S4
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

28892:METLI RS08260
gene id: 28892:METLI_RS08260
uniprot id: J1L4D5
names: Function
names: Similarity
messages: Antitoxin component of a type II toxin-antitoxin (TA) system.
messages: Belongs to the UPF0165 family.

28892:METLI RS03205
gene id: 28892:METLI_RS03205
uniprot id: J1ANY0
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS02225
gene id: 28892:METLI_RS02225
uniprot id: J1L0A8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

28892:METLI RS08850
gene id: 28892:METLI_RS08850
uniprot id: J0SAL9
names: Function
names: Similarity
messages: Belongs to the CobB/CobQ family. CobQ subfamily.
messages: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.

28892:METLI RS08835
gene id: 28892:METLI_RS08835
uniprot id: J0S1G9
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS04520
gene id: 28892:METLI_RS04520
uniprot id: J1L2J4
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS02310
gene id: 28892:METLI_RS02310
uniprot id: J0S7D2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cytidylate kinase family. Type 2 subfamily.
messages: Cytoplasm

28892:METLI RS03290
gene id: 28892:METLI_RS03290
uniprot id: J0S7V1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS10940
gene id: 28892:METLI_RS10940
uniprot id: J1ASV1
names: Similarity
messages: Belongs to the carbamoyltransferase HypF family.

28892:METLI RS01345
gene id: 28892:METLI_RS01345
uniprot id: J1L0U1
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS08570
gene id: 28892:METLI_RS08570
uniprot id: J0SAG7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

28892:METLI RS00715
gene id: 28892:METLI_RS00715
uniprot id: J0RX73
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

28892:METLI RS03275
gene id: 28892:METLI_RS03275
uniprot id: J1L0U8
names: Cofactor
names: Similarity
messages: Belongs to the MsrB Met sulfoxide reductase family.
messages: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.

28892:METLI RS01715
gene id: 28892:METLI_RS01715
uniprot id: J1L124
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Part of the 30S ribosomal subunit.
messages: With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.

28892:METLI RS03295
gene id: 28892:METLI_RS03295
uniprot id: J1L1S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

28892:METLI RS09680
gene id: 28892:METLI_RS09680
uniprot id: J1AS85
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
messages: Binds 1 FAD per subunit.
messages: Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduction reaction proceeds via syn addition of hydrogen for double bonds.

28892:METLI RS05485
gene id: 28892:METLI_RS05485
uniprot id: J1L2X7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm

28892:METLI RS03460
gene id: 28892:METLI_RS03460
uniprot id: J1L0Y0
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS03920
gene id: 28892:METLI_RS03920
uniprot id: J1APB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FNT transporter (TC 2.A.44) family.
messages: Membrane

28892:METLI RS07540
gene id: 28892:METLI_RS07540
uniprot id: J1L333
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CetZ family.
messages: Cytoplasm
messages: Involved in cell shape control.

28892:METLI RS03600
gene id: 28892:METLI_RS03600
uniprot id: J0S804
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 2 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

28892:METLI RS00655
gene id: 28892:METLI_RS00655
uniprot id: J0S6G2
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

28892:METLI RS08465
gene id: 28892:METLI_RS08465
uniprot id: J0SAE9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

28892:METLI RS10830
gene id: 28892:METLI_RS10830
uniprot id: J1L5N7
names: Similarity
messages: Belongs to the AOR/FOR family.

28892:METLI RS00015
gene id: 28892:METLI_RS00015
uniprot id: J0RWU2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

28892:METLI RS04105
gene id: 28892:METLI_RS04105
uniprot id: J0S892
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

28892:METLI RS09385
gene id: 28892:METLI_RS09385
uniprot id: J1AS36
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

28892:METLI RS05550
gene id: 28892:METLI_RS05550
uniprot id: J1AQ62
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NadC/ModD family.
messages: Hexamer formed by 3 homodimers.
messages: Involved in the catabolism of quinolinic acid (QA).

28892:METLI RS03510
gene id: 28892:METLI_RS03510
uniprot id: J0RYN9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.
messages: Cell membrane
messages: Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.

28892:METLI RS12210
gene id: 28892:METLI_RS12210
uniprot id: J1L5K8
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS12040
gene id: 28892:METLI_RS12040
uniprot id: J0SCB5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

28892:METLI RS05610
gene id: 28892:METLI_RS05610
uniprot id: J0RZT1
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS01365
gene id: 28892:METLI_RS01365
uniprot id: J0S6S6
names: Function
names: Similarity
messages: Belongs to the EF-1-beta/EF-1-delta family.
messages: Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.

28892:METLI RS08955
gene id: 28892:METLI_RS08955
uniprot id: J0S1I9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL31 family.

28892:METLI RS11720
gene id: 28892:METLI_RS11720
uniprot id: J1L655
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.

28892:METLI RS08265
gene id: 28892:METLI_RS08265
uniprot id: J0S164
names: Function
names: Similarity
messages: Belongs to the PINc/VapC protein family.
messages: Toxic component of a toxin-antitoxin (TA) system. An RNase.

28892:METLI RS04265
gene id: 28892:METLI_RS04265
uniprot id: J0RZ74
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SLC41A transporter family.
messages: Membrane

28892:METLI RS09260
gene id: 28892:METLI_RS09260
uniprot id: J1L3Z4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

28892:METLI RS07165
gene id: 28892:METLI_RS07165
uniprot id: J1L2W6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

28892:METLI RS03370
gene id: 28892:METLI_RS03370
uniprot id: J1L1U3
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS11905
gene id: 28892:METLI_RS11905
uniprot id: J1L5G6
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

28892:METLI RS02200
gene id: 28892:METLI_RS02200
uniprot id: J1L0A5
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

28892:METLI RS07065
gene id: 28892:METLI_RS07065
uniprot id: J1L2V1
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

28892:METLI RS05360
gene id: 28892:METLI_RS05360
uniprot id: J1L2V6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

28892:METLI RS09550
gene id: 28892:METLI_RS09550
uniprot id: J0S1Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MntP (TC 9.B.29) family.
messages: Cell membrane
messages: Probably functions as a manganese efflux pump.

28892:METLI RS07555
gene id: 28892:METLI_RS07555
uniprot id: J1L426
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS09230
gene id: 28892:METLI_RS09230
uniprot id: J0S1P3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

28892:METLI RS01235
gene id: 28892:METLI_RS01235
uniprot id: J1L0S3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FGAMS family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

28892:METLI RS05920
gene id: 28892:METLI_RS05920
uniprot id: J1L362
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

28892:METLI RS06020
gene id: 28892:METLI_RS06020
uniprot id: J1L381
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine-cytosine permease (2.A.39) family.
messages: Membrane

28892:METLI RS11675
gene id: 28892:METLI_RS11675
uniprot id: J0S2Z2
names: Similarity
messages: Belongs to the deoxyhypusine synthase family.

28892:METLI RS06895
gene id: 28892:METLI_RS06895
uniprot id: J0S0J2
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS07425
gene id: 28892:METLI_RS07425
uniprot id: J1AR54
names: Domain
names: Function
names: Miscellaneous
names: Similarity
messages: Belongs to the CobB/CbiA family.
messages: Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
messages: Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP, and cobyrinate or Ni-sirohydrochlorin, and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.
messages: The a and c carboxylates of cobyrinate and Ni-sirohydrochlorin are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.

28892:METLI RS06900
gene id: 28892:METLI_RS06900
uniprot id: J1AQX2
names: Similarity
messages: Belongs to the anti-sigma-factor antagonist family.

28892:METLI RS10675
gene id: 28892:METLI_RS10675
uniprot id: J0SBI2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

28892:METLI RS09025
gene id: 28892:METLI_RS09025
uniprot id: J1L4R9
names: Similarity
messages: Belongs to the eukaryotic/archaeal PrmC-related family.

28892:METLI RS01685
gene id: 28892:METLI_RS01685
uniprot id: J0S6Z9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

28892:METLI RS00390
gene id: 28892:METLI_RS00390
uniprot id: J0RX04
names: Function
names: Similarity
messages: Belongs to the ATPase alpha/beta chains family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.

28892:METLI RS09475
gene id: 28892:METLI_RS09475
uniprot id: J0S1W7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS03625
gene id: 28892:METLI_RS03625
uniprot id: J1L1Z5
names: Similarity
messages: Belongs to the CTAG/PCC1 family.

28892:METLI RS00505
gene id: 28892:METLI_RS00505
uniprot id: J0S6D3
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

28892:METLI RS03955
gene id: 28892:METLI_RS03955
uniprot id: J1L268
names: Function
names: Similarity
names: Subunit
messages: Belongs to the SepCysS family.
messages: Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)).
messages: Homodimer. Interacts with SepRS.

28892:METLI RS00230
gene id: 28892:METLI_RS00230
uniprot id: J1L085
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

28892:METLI RS06785
gene id: 28892:METLI_RS06785
uniprot id: J0S9M7
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS00690
gene id: 28892:METLI_RS00690
uniprot id: J0RX68
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

28892:METLI RS04420
gene id: 28892:METLI_RS04420
uniprot id: J0RZ99
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

28892:METLI RS10635
gene id: 28892:METLI_RS10635
uniprot id: J1L5K4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS04660
gene id: 28892:METLI_RS04660
uniprot id: J1APS6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm

28892:METLI RS01460
gene id: 28892:METLI_RS01460
uniprot id: J1L0W4
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS06670
gene id: 28892:METLI_RS06670
uniprot id: J1AQQ5
names: Caution
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutS family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.

28892:METLI RS00365
gene id: 28892:METLI_RS00365
uniprot id: J0RWZ8
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase proteolipid subunit family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

28892:METLI RS03090
gene id: 28892:METLI_RS03090
uniprot id: J0RYG1
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.
messages: Binds 1 [3Fe-4S] cluster.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

28892:METLI RS01040
gene id: 28892:METLI_RS01040
uniprot id: J1L0P3
names: Similarity
messages: Belongs to the acylphosphatase family.

28892:METLI RS05620
gene id: 28892:METLI_RS05620
uniprot id: J1AQ74
names: Function
names: Subunit
messages: Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.
messages: Heterodimer of the IorA and IorB subunits.

28892:METLI RS03615
gene id: 28892:METLI_RS03615
uniprot id: J1L105
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

28892:METLI RS02905
gene id: 28892:METLI_RS02905
uniprot id: J1L1K8
names: Function
names: Similarity
messages: Belongs to the ferredoxin thioredoxin reductase beta subunit family.
messages: Catalytic subunit of the ferredoxin-thioredoxin reductase (FTR), which catalyzes the two-electron reduction of thioredoxins by the electrons provided by reduced ferredoxin.

28892:METLI RS02710
gene id: 28892:METLI_RS02710
uniprot id: J1L0K2
names: Function
names: Similarity
messages: Belongs to the glutamate synthase family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

28892:METLI RS02950
gene id: 28892:METLI_RS02950
uniprot id: J0S7P7
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS08580
gene id: 28892:METLI_RS08580
uniprot id: J1L3L2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
messages: Cytoplasm
messages: Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.
messages: In Archaea the pyridoxal phosphate cofactor is not covalently bound to Lys but ligated by other amino acids.
messages: Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.

28892:METLI RS06600
gene id: 28892:METLI_RS06600
uniprot id: J1AQN9
names: Similarity
messages: Belongs to the Nth/MutY family.

28892:METLI RS02130
gene id: 28892:METLI_RS02130
uniprot id: J0S7A3
names: Similarity
messages: Belongs to the intimin/invasin family.

28892:METLI RS01675
gene id: 28892:METLI_RS01675
uniprot id: J1KZZ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. O-phosphoseryl-tRNA(Cys) synthetase subfamily.
messages: Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).
messages: Homotetramer. Interacts with SepCysS.

28892:METLI RS11360
gene id: 28892:METLI_RS11360
uniprot id: J0S2S9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS04760
gene id: 28892:METLI_RS04760
uniprot id: J1APU2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS04410
gene id: 28892:METLI_RS04410
uniprot id: J0S8F9
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS17 family.

28892:METLI RS03585
gene id: 28892:METLI_RS03585
uniprot id: J0RYQ1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

28892:METLI RS04390
gene id: 28892:METLI_RS04390
uniprot id: J1L2H5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic-type primase large subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Heterodimer of a small subunit (PriS) and a large subunit (PriL).
messages: Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

28892:METLI RS08620
gene id: 28892:METLI_RS08620
uniprot id: J1L4J1
names: Similarity
messages: Belongs to the UPF0047 family.

28892:METLI RS07060
gene id: 28892:METLI_RS07060
uniprot id: J0S0L9
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

28892:METLI RS01440
gene id: 28892:METLI_RS01440
uniprot id: J1L0V9
names: Similarity
messages: Belongs to the glycogen phosphorylase family.

28892:METLI RS07565
gene id: 28892:METLI_RS07565
uniprot id: J1L337
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL8 family.
messages: Cytoplasm
messages: Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
messages: Part of the 50S ribosomal subunit. Probably part of the RNase P complex.

28892:METLI RS02590
gene id: 28892:METLI_RS02590
uniprot id: J1ANP6
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

28892:METLI RS05280
gene id: 28892:METLI_RS05280
uniprot id: J0S8U8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

28892:METLI RS05530
gene id: 28892:METLI_RS05530
uniprot id: J0S8Z8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CitM (TC 2.A.11) transporter family.
messages: Cell membrane
messages: Membrane

28892:METLI RS05805
gene id: 28892:METLI_RS05805
uniprot id: J1L339
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

28892:METLI RS10785
gene id: 28892:METLI_RS10785
uniprot id: J0S2H6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamine synthetase family.
messages: Cytoplasm

28892:METLI RS09190
gene id: 28892:METLI_RS09190
uniprot id: J1ARX8
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS09060
gene id: 28892:METLI_RS09060
uniprot id: J1L3V2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

28892:METLI RS02595
gene id: 28892:METLI_RS02595
uniprot id: J0S7I7
names: Function
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).

28892:METLI RS01275
gene id: 28892:METLI_RS01275
uniprot id: J1AN12
names: Similarity
messages: Belongs to the peptidase M24B family.

28892:METLI RS02535
gene id: 28892:METLI_RS02535
uniprot id: J1L0H0
names: Similarity
messages: Belongs to the alpha-IPM synthase/homocitrate synthase family.

28892:METLI RS06705
gene id: 28892:METLI_RS06705
uniprot id: J0S9K5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

28892:METLI RS10265
gene id: 28892:METLI_RS10265
uniprot id: J1ASI4
names: Function
names: Similarity
messages: Belongs to the V-ATPase D subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

28892:METLI RS01360
gene id: 28892:METLI_RS01360
uniprot id: J1AN26
names: Function
names: Similarity
messages: Belongs to the LDH/MDH superfamily.
messages: Catalyzes the reversible oxidation of malate to oxaloacetate.

28892:METLI RS11625
gene id: 28892:METLI_RS11625
uniprot id: J0S2Y2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.

28892:METLI RS04655
gene id: 28892:METLI_RS04655
uniprot id: J1L1L4
names: Similarity
messages: Belongs to the HMBS family.

28892:METLI RS02680
gene id: 28892:METLI_RS02680
uniprot id: J0RYA0
names: Similarity
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.

28892:METLI RS09790
gene id: 28892:METLI_RS09790
uniprot id: J1L4A3
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS10185
gene id: 28892:METLI_RS10185
uniprot id: J0S274
names: Similarity
messages: Belongs to the peptidase U62 family.

28892:METLI RS07600
gene id: 28892:METLI_RS07600
uniprot id: J0SA02
names: Function
names: Similarity
messages: Belongs to the threonine synthase family.
messages: Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.

28892:METLI RS09640
gene id: 28892:METLI_RS09640
uniprot id: J0SB18
names: Similarity
messages: Belongs to the eIF-2-alpha family.

28892:METLI RS03005
gene id: 28892:METLI_RS03005
uniprot id: J0S7Q2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PEPCase type 2 family.
messages: Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
messages: Homotetramer.

28892:METLI RS09285
gene id: 28892:METLI_RS09285
uniprot id: J1L419
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

28892:METLI RS05670
gene id: 28892:METLI_RS05670
uniprot id: J1L238
names: Similarity
messages: Belongs to the helicase family. RAD3/XPD subfamily.

28892:METLI RS05345
gene id: 28892:METLI_RS05345
uniprot id: J1L1Y2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

28892:METLI RS05945
gene id: 28892:METLI_RS05945
uniprot id: J1L367
names: Similarity
messages: Belongs to the AAA ATPase family.

28892:METLI RS09195
gene id: 28892:METLI_RS09195
uniprot id: J0SAT8
names: Similarity
messages: Belongs to the phosphoribulokinase family.

28892:METLI RS09635
gene id: 28892:METLI_RS09635
uniprot id: J1AS77
names: Cofactor
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS27 family.
messages: Binds 1 zinc ion per subunit.

28892:METLI RS05270
gene id: 28892:METLI_RS05270
uniprot id: J1L1W9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HCP family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 hybrid [4Fe-2O-2S] cluster.
messages: Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
messages: Cytoplasm

28892:METLI RS08880
gene id: 28892:METLI_RS08880
uniprot id: J1L4P1
names: Similarity
messages: Belongs to the small heat shock protein (HSP20) family.

28892:METLI RS08940
gene id: 28892:METLI_RS08940
uniprot id: J1L3S3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS19 family.
messages: May be involved in maturation of the 30S ribosomal subunit.
messages: Part of the 30S ribosomal subunit.

28892:METLI RS02605
gene id: 28892:METLI_RS02605
uniprot id: J0RY87
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NifD/NifK/NifE/NifN family.
messages: Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).
messages: This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.

28892:METLI RS07345
gene id: 28892:METLI_RS07345
uniprot id: J1L2Z5
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

28892:METLI RS05940
gene id: 28892:METLI_RS05940
uniprot id: J0S976
names: Similarity
messages: Belongs to the UPF0107 family.

28892:METLI RS10240
gene id: 28892:METLI_RS10240
uniprot id: J1ASI2
names: Function
names: Similarity
messages: Belongs to the V-ATPase E subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

28892:METLI RS07225
gene id: 28892:METLI_RS07225
uniprot id: J0S9U6
names: Similarity
messages: Belongs to the MCM family.

28892:METLI RS09655
gene id: 28892:METLI_RS09655
uniprot id: J1AS82
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CbiM family.
messages: Cell membrane
messages: Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.
messages: Membrane
messages: Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.

28892:METLI RS07050
gene id: 28892:METLI_RS07050
uniprot id: J0S9R6
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M42 family.
messages: Binds 2 divalent metal cations per subunit.

28892:METLI RS05740
gene id: 28892:METLI_RS05740
uniprot id: J0RZV3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
messages: Homotrimer.

28892:METLI RS01455
gene id: 28892:METLI_RS01455
uniprot id: J0S6U6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS02930
gene id: 28892:METLI_RS02930
uniprot id: J1L1L1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofC family.
messages: Guanylyltransferase that catalyzes the activation of (2S)-2-phospholactate (2-PL) as (2S)-lactyl-2-diphospho-5'-guanosine, via the condensation of 2-PL with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
messages: Homodimer.

28892:METLI RS00490
gene id: 28892:METLI_RS00490
uniprot id: J0RX28
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

28892:METLI RS01705
gene id: 28892:METLI_RS01705
uniprot id: J1ANB2
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.
messages: Binds 1 S-adenosyl-L-methionine per subunit.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS06485
gene id: 28892:METLI_RS06485
uniprot id: J1AQL5
names: Similarity
messages: Belongs to the TBP family.

28892:METLI RS10990
gene id: 28892:METLI_RS10990
uniprot id: J1ASW1
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Part of the 30S ribosomal subunit.

28892:METLI RS00375
gene id: 28892:METLI_RS00375
uniprot id: J1AMK5
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.

28892:METLI RS03965
gene id: 28892:METLI_RS03965
uniprot id: J1L170
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ThiI family.
messages: Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS04190
gene id: 28892:METLI_RS04190
uniprot id: J0RZ50
names: Function
names: Similarity
messages: Belongs to the MfnB family.
messages: Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).

28892:METLI RS07160
gene id: 28892:METLI_RS07160
uniprot id: J0S0N5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Membrane

28892:METLI RS02920
gene id: 28892:METLI_RS02920
uniprot id: J1ANU7
names: Similarity
messages: Belongs to the SAICAR synthetase family.

28892:METLI RS02215
gene id: 28892:METLI_RS02215
uniprot id: J1L1A8
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

28892:METLI RS08430
gene id: 28892:METLI_RS08430
uniprot id: J1L3I8
names: Similarity
messages: Belongs to the intimin/invasin family.

28892:METLI RS07520
gene id: 28892:METLI_RS07520
uniprot id: J1AR72
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

28892:METLI RS04820
gene id: 28892:METLI_RS04820
uniprot id: J1L2N5
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS08985
gene id: 28892:METLI_RS08985
uniprot id: J1L3T4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the methyltransferase superfamily. TrmY family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.

28892:METLI RS05955
gene id: 28892:METLI_RS05955
uniprot id: J1L292
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
messages: Belongs to the AAA ATPase family.
messages: Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.
messages: Cytoplasm
messages: Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.

28892:METLI RS04065
gene id: 28892:METLI_RS04065
uniprot id: J0S883
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

28892:METLI RS09330
gene id: 28892:METLI_RS09330
uniprot id: J1L436
names: Function
messages: Catalyzes the synthesis of GMP from XMP.

28892:METLI RS06910
gene id: 28892:METLI_RS06910
uniprot id: J1L3T1
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS11585
gene id: 28892:METLI_RS11585
uniprot id: J1AT51
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-I 3-dehydroquinase family.
messages: Homodimer.
messages: Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.

28892:METLI RS09340
gene id: 28892:METLI_RS09340
uniprot id: J0SAX8
names: Similarity
messages: Belongs to the thioesterase PaaI family.

28892:METLI RS10590
gene id: 28892:METLI_RS10590
uniprot id: J0S2D7
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Membrane

28892:METLI RS02625
gene id: 28892:METLI_RS02625
uniprot id: J1L1G2
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the AP endonuclease 2 family.
messages: Binds 3 Zn(2+) ions.
messages: Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.

28892:METLI RS01500
gene id: 28892:METLI_RS01500
uniprot id: J1AN56
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TMEM175 family.
messages: Membrane

28892:METLI RS07170
gene id: 28892:METLI_RS07170
uniprot id: J1AR13
names: Cofactor
names: Similarity
messages: Belongs to the TPP enzyme family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.

28892:METLI RS09815
gene id: 28892:METLI_RS09815
uniprot id: J0S217
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds at least 2 Zn(2+) per subunit.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

28892:METLI RS02540
gene id: 28892:METLI_RS02540
uniprot id: J1ANP0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
messages: Heterodimer of LeuC and LeuD.

28892:METLI RS01775
gene id: 28892:METLI_RS01775
uniprot id: J1L032
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CofD family.
messages: Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS02400
gene id: 28892:METLI_RS02400
uniprot id: J1ANL9
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Belongs to the MtrG family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

28892:METLI RS08775
gene id: 28892:METLI_RS08775
uniprot id: J0SAK5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PRA-CH family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
messages: Cytoplasm
messages: Homodimer.

28892:METLI RS05735
gene id: 28892:METLI_RS05735
uniprot id: J1L325
names: Similarity
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

28892:METLI RS01865
gene id: 28892:METLI_RS01865
uniprot id: J0S765
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the diaminopimelate epimerase family.
messages: Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS04570
gene id: 28892:METLI_RS04570
uniprot id: J1L2K3
names: Similarity
messages: Belongs to the GARS family.

28892:METLI RS03085
gene id: 28892:METLI_RS03085
uniprot id: J1L1N7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL18 family.

28892:METLI RS11245
gene id: 28892:METLI_RS11245
uniprot id: J1L5W3
names: Similarity
messages: Belongs to the dihydropyrimidine dehydrogenase family.

28892:METLI RS02265
gene id: 28892:METLI_RS02265
uniprot id: J1L1B5
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eL32 family.

28892:METLI RS10605
gene id: 28892:METLI_RS10605
uniprot id: J0SBH0
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

28892:METLI RS02275
gene id: 28892:METLI_RS02275
uniprot id: J1L0B8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

28892:METLI RS02335
gene id: 28892:METLI_RS02335
uniprot id: J0S7D8
names: Similarity
messages: Belongs to the TrpF family.

28892:METLI RS07680
gene id: 28892:METLI_RS07680
uniprot id: J1L446
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

28892:METLI RS11630
gene id: 28892:METLI_RS11630
uniprot id: J1L572
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Cytoplasm

28892:METLI RS03045
gene id: 28892:METLI_RS03045
uniprot id: J1L0Q6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
messages: Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.
messages: Cytoplasm
messages: Homodimer.

28892:METLI RS05480
gene id: 28892:METLI_RS05480
uniprot id: J0S8Y8
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
messages: Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
messages: Cytoplasm
messages: Feedback inhibited by histidine.

28892:METLI RS01435
gene id: 28892:METLI_RS01435
uniprot id: J0S6U1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).
messages: Belongs to the TDD superfamily. TSR3 family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS05980
gene id: 28892:METLI_RS05980
uniprot id: J1L296
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the archaeosine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.

28892:METLI RS04525
gene id: 28892:METLI_RS04525
uniprot id: J0RZB4
names: Similarity
messages: Belongs to the UPF0235 family.

28892:METLI RS08550
gene id: 28892:METLI_RS08550
uniprot id: J1L4H8
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'-methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'-deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'-deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'-deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: SAH is a product of SAM methyltransferases and is known to be a feedback inhibitor of these enzymes. As a result of this inhibition, organisms have evolved efficient enzymes to metabolize SAH via different pathways. The pathway found in methanogens differs from the canonical pathway, it uses the deamination of S-adenosyl-L-homocysteine to form S-inosyl-L-homocysteine for the regeneration of SAM from S-adenosyl-L-homocysteine. 5'-deoxyadenosine is a radical SAM enzyme reaction product which strongly inhibits radical SAM enzymes. A pathway for removing this product must be present in methanogens where the MTA/SAH nucleosidase which normally metabolizes this compound is absent.

28892:METLI RS08515
gene id: 28892:METLI_RS08515
uniprot id: J0SAF9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

28892:METLI RS02280
gene id: 28892:METLI_RS02280
uniprot id: J1ANK4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Part of the 30S ribosomal subunit. Contacts protein S4.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

28892:METLI RS01570
gene id: 28892:METLI_RS01570
uniprot id: J1KZW9
names: Similarity
messages: Belongs to the HMG-CoA reductase family.

28892:METLI RS02700
gene id: 28892:METLI_RS02700
uniprot id: J1L1H3
names: Similarity
messages: Belongs to the adenosylhomocysteinase family.

28892:METLI RS04515
gene id: 28892:METLI_RS04515
uniprot id: J0S8H3
names: Similarity
messages: Belongs to the HypE family.

28892:METLI RS05310
gene id: 28892:METLI_RS05310
uniprot id: J1L2U8
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.

28892:METLI RS10285
gene id: 28892:METLI_RS10285
uniprot id: J1L4I0
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS06315
gene id: 28892:METLI_RS06315
uniprot id: J0S061
names: Similarity
messages: Belongs to the archease family.

28892:METLI RS00595
gene id: 28892:METLI_RS00595
uniprot id: J1KZE2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

28892:METLI RS10230
gene id: 28892:METLI_RS10230
uniprot id: J0S284
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the V-ATPase 116 kDa subunit family.
messages: Membrane

28892:METLI RS05495
gene id: 28892:METLI_RS05495
uniprot id: J1L208
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal histone HMF family.
messages: Chromosome
messages: Cytoplasm

28892:METLI RS07285
gene id: 28892:METLI_RS07285
uniprot id: J1L3Z0
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS02600
gene id: 28892:METLI_RS02600
uniprot id: J1L1F8
names: Similarity
messages: Belongs to the NifD/NifK/NifE/NifN family.

28892:METLI RS07580
gene id: 28892:METLI_RS07580
uniprot id: J1L429
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

28892:METLI RS04385
gene id: 28892:METLI_RS04385
uniprot id: J0S8F6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PCNA family.
messages: Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.
messages: Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
messages: Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.

28892:METLI RS07230
gene id: 28892:METLI_RS07230
uniprot id: J1L3Y1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the activator 1 small subunits family. RfcS subfamily.
messages: Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).
messages: Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.

28892:METLI RS03550
gene id: 28892:METLI_RS03550
uniprot id: J0S7Z4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PyrI family.
messages: Binds 1 zinc ion per subunit.
messages: Contains catalytic and regulatory chains.
messages: Involved in allosteric regulation of aspartate carbamoyltransferase.

28892:METLI RS07840
gene id: 28892:METLI_RS07840
uniprot id: J1ARC0
names: Function
names: Similarity
messages: Belongs to the rubredoxin family.
messages: Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.

28892:METLI RS03080
gene id: 28892:METLI_RS03080
uniprot id: J0S7R5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

28892:METLI RS08590
gene id: 28892:METLI_RS08590
uniprot id: J0SAH2
names: Similarity
messages: Belongs to the UPF0173 family.

28892:METLI RS06040
gene id: 28892:METLI_RS06040
uniprot id: J0S995
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

28892:METLI RS02300
gene id: 28892:METLI_RS02300
uniprot id: J1L0C3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal adenylate kinase family.
messages: Cytoplasm

28892:METLI RS02510
gene id: 28892:METLI_RS02510
uniprot id: J0RY71
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FTR family.
messages: Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR).
messages: Cytoplasm
messages: Homotetramer.

28892:METLI RS11620
gene id: 28892:METLI_RS11620
uniprot id: J1L638
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
messages: Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
messages: Homodecamer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS11890
gene id: 28892:METLI_RS11890
uniprot id: J0SC94
names: Similarity
messages: Belongs to the phosphohexose mutase family.

28892:METLI RS11485
gene id: 28892:METLI_RS11485
uniprot id: J1AT34
names: Similarity
messages: Belongs to the aspartokinase family.

28892:METLI RS09445
gene id: 28892:METLI_RS09445
uniprot id: J1L527
names: Function
names: Similarity
names: Subunit
messages: Belongs to the ribose 5-phosphate isomerase family.
messages: Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
messages: Homodimer.

28892:METLI RS04120
gene id: 28892:METLI_RS04120
uniprot id: J1L1A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the archaeal NMN adenylyltransferase family.
messages: Cytoplasm

28892:METLI RS02410
gene id: 28892:METLI_RS02410
uniprot id: J1L1D4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrA family.
messages: Binds 1 5-hydroxybenzimidazolylcobamide group.
messages: Cell membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

28892:METLI RS05580
gene id: 28892:METLI_RS05580
uniprot id: J0S908
names: Similarity
messages: Belongs to the DNA polymerase type-B family.

28892:METLI RS03075
gene id: 28892:METLI_RS03075
uniprot id: J1ANW4
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

28892:METLI RS05285
gene id: 28892:METLI_RS05285
uniprot id: J1L2U5
names: Similarity
messages: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.

28892:METLI RS05985
gene id: 28892:METLI_RS05985
uniprot id: J1AQC9
names: Similarity
messages: Belongs to the archaeosine synthase type 1 family.

28892:METLI RS02420
gene id: 28892:METLI_RS02420
uniprot id: J1L0E7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrC family.
messages: Cell membrane
messages: Membrane
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

28892:METLI RS02435
gene id: 28892:METLI_RS02435
uniprot id: J0RY59
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase alpha subunit family.
messages: Binds 2 coenzyme F430 non-covalently per MCR complex. Coenzyme F430 is a yellow nickel porphinoid. Methyl-coenzyme-M reductase is activated when the enzyme-bound coenzyme F430 is reduced to the Ni(I) oxidation state.
messages: Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2-(methylthio)ethanesulfonate) using coenzyme B (CoB or 7-mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

28892:METLI RS07870
gene id: 28892:METLI_RS07870
uniprot id: J1ARC5
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TFE family.
messages: Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.
messages: The winged helix domain is involved in binding to DNA in the preinitiation complex.
messages: Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.

28892:METLI RS08625
gene id: 28892:METLI_RS08625
uniprot id: J0S1C9
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS09560
gene id: 28892:METLI_RS09560
uniprot id: J1AS64
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endonuclease V family.
messages: Cytoplasm
messages: DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.

28892:METLI RS05795
gene id: 28892:METLI_RS05795
uniprot id: J1AQ97
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

28892:METLI RS03870
gene id: 28892:METLI_RS03870
uniprot id: J0RYV3
names: Similarity
messages: Belongs to the UPF0175 family.

28892:METLI RS02255
gene id: 28892:METLI_RS02255
uniprot id: J1ANK0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit.

28892:METLI RS09820
gene id: 28892:METLI_RS09820
uniprot id: J1L4A6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta' chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.
messages: Part of the RNA polymerase complex.

28892:METLI RS03390
gene id: 28892:METLI_RS03390
uniprot id: J0S7W7
names: Similarity
messages: Belongs to the serpin family.

28892:METLI RS04840
gene id: 28892:METLI_RS04840
uniprot id: J0S8M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

28892:METLI RS09580
gene id: 28892:METLI_RS09580
uniprot id: J1L472
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.
messages: Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
messages: Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
messages: Cytoplasm
messages: Homodimer.

28892:METLI RS03105
gene id: 28892:METLI_RS03105
uniprot id: J0S7S0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

28892:METLI RS11915
gene id: 28892:METLI_RS11915
uniprot id: J0SC97
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

28892:METLI RS11735
gene id: 28892:METLI_RS11735
uniprot id: J1AT79
names: Similarity
messages: Belongs to the thiolase-like superfamily. UPF0219 family.

28892:METLI RS01905
gene id: 28892:METLI_RS01905
uniprot id: J1L056
names: Similarity
messages: Belongs to the UPF0288 family.

28892:METLI RS06815
gene id: 28892:METLI_RS06815
uniprot id: J1L3R6
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS02910
gene id: 28892:METLI_RS02910
uniprot id: J0RYD5
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Cytoplasm
messages: Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.
messages: Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.

28892:METLI RS07270
gene id: 28892:METLI_RS07270
uniprot id: J1L2Y2
names: Similarity
messages: Belongs to the phosphohexose mutase family.

28892:METLI RS10815
gene id: 28892:METLI_RS10815
uniprot id: J1L4S0
names: Similarity
messages: Belongs to the P(II) protein family.

28892:METLI RS02240
gene id: 28892:METLI_RS02240
uniprot id: J1L1B1
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS4 family.

28892:METLI RS04565
gene id: 28892:METLI_RS04565
uniprot id: J0S8I2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.

28892:METLI RS05860
gene id: 28892:METLI_RS05860
uniprot id: J0RZX7
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS07095
gene id: 28892:METLI_RS07095
uniprot id: J1AR02
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

28892:METLI RS05745
gene id: 28892:METLI_RS05745
uniprot id: J1L250
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

28892:METLI RS02925
gene id: 28892:METLI_RS02925
uniprot id: J0S7P3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofG family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

28892:METLI RS09665
gene id: 28892:METLI_RS09665
uniprot id: J1L562
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS09375
gene id: 28892:METLI_RS09375
uniprot id: J0S1V1
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the histidinol dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.

28892:METLI RS06295
gene id: 28892:METLI_RS06295
uniprot id: J1L2E8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Involved in protein export.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the protein translocation apparatus. Forms a complex with SecF.

28892:METLI RS10655
gene id: 28892:METLI_RS10655
uniprot id: J0SBH9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. Probably involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
messages: Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.

28892:METLI RS08480
gene id: 28892:METLI_RS08480
uniprot id: J1L3J4
names: Similarity
names: Subunit
messages: Belongs to the methyl-coenzyme M reductase beta subunit family.
messages: Hexamer of two alpha, two beta, and two gamma chains.
messages: MCR is a hexamer of two alpha, two beta, and two gamma chains, forming a dimer of heterotrimers.

28892:METLI RS01820
gene id: 28892:METLI_RS01820
uniprot id: J0RXW4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.
messages: Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS09200
gene id: 28892:METLI_RS09200
uniprot id: J1L4V4
names: Cofactor
names: Similarity
messages: Belongs to the desulfoferrodoxin family.
messages: Binds 1 Fe(2+) ion per subunit. The iron ion 2 is coordinated via four histidines and one cysteine residue.
messages: Binds 1 Fe(3+) ion per subunit. The iron ion 1 is coordinated via 4 cysteine residues.

28892:METLI RS00135
gene id: 28892:METLI_RS00135
uniprot id: J1L066
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

28892:METLI RS02490
gene id: 28892:METLI_RS02490
uniprot id: J1L0G1
names: Similarity
messages: Belongs to the HdrB family.

28892:METLI RS04770
gene id: 28892:METLI_RS04770
uniprot id: J1L2M9
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS05725
gene id: 28892:METLI_RS05725
uniprot id: J1AQ86
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

28892:METLI RS10905
gene id: 28892:METLI_RS10905
uniprot id: J0S2J7
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS11650
gene id: 28892:METLI_RS11650
uniprot id: J0S2Y6
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

28892:METLI RS09510
gene id: 28892:METLI_RS09510
uniprot id: J1AS56
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS04290
gene id: 28892:METLI_RS04290
uniprot id: J0RZ79
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ThiC family.
messages: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS02380
gene id: 28892:METLI_RS02380
uniprot id: J0S7E7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

28892:METLI RS00070
gene id: 28892:METLI_RS00070
uniprot id: J1KZ49
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal FAD synthase family.
messages: Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.
messages: Homodimer.

28892:METLI RS04530
gene id: 28892:METLI_RS04530
uniprot id: J1L1J6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DnaG primase family.
messages: Forms a ternary complex with MCM helicase and DNA.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

28892:METLI RS02425
gene id: 28892:METLI_RS02425
uniprot id: J1ANM2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MtrD family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
messages: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH.

28892:METLI RS02295
gene id: 28892:METLI_RS02295
uniprot id: J0RY35
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

28892:METLI RS01270
gene id: 28892:METLI_RS01270
uniprot id: J1KZQ4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).

28892:METLI RS07355
gene id: 28892:METLI_RS07355
uniprot id: J0S9W6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
messages: Membrane

28892:METLI RS05160
gene id: 28892:METLI_RS05160
uniprot id: J1L1V1
names: Similarity
messages: Belongs to the thioesterase PaaI family.

28892:METLI RS02250
gene id: 28892:METLI_RS02250
uniprot id: J1L0B3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles.
messages: Part of the 30S ribosomal subunit.

28892:METLI RS07685
gene id: 28892:METLI_RS07685
uniprot id: J0S0W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MCH family.
messages: Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+).
messages: Cytoplasm

28892:METLI RS01840
gene id: 28892:METLI_RS01840
uniprot id: J1L152
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

28892:METLI RS10880
gene id: 28892:METLI_RS10880
uniprot id: J1L5P5
names: Function
names: Similarity
messages: Belongs to the glutaredoxin family.
messages: Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro.

28892:METLI RS04415
gene id: 28892:METLI_RS04415
uniprot id: J1L2H9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

28892:METLI RS05410
gene id: 28892:METLI_RS05410
uniprot id: J1L2W3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the succinate/malate CoA ligase alpha subunit family.
messages: Heterotetramer of two alpha and two beta subunits.
messages: Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.

28892:METLI RS05340
gene id: 28892:METLI_RS05340
uniprot id: J0RZN6
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the asparaginase 1 family. GatD subfamily.
messages: Heterodimer of GatD and GatE.

28892:METLI RS02220
gene id: 28892:METLI_RS02220
uniprot id: J0RY26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic/archaeal RNase P protein component 1 family.
messages: Consists of a catalytic RNA component and at least 4-5 protein subunits.
messages: Cytoplasm
messages: Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

28892:METLI RS05335
gene id: 28892:METLI_RS05335
uniprot id: J1L2V2
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.
messages: Belongs to the GatB/GatE family. GatE subfamily.
messages: Heterodimer of GatD and GatE.

28892:METLI RS08820
gene id: 28892:METLI_RS08820
uniprot id: J1ARR7
names: Similarity
messages: Belongs to the ParA family. MinD subfamily.

28892:METLI RS10340
gene id: 28892:METLI_RS10340
uniprot id: J1ASJ8
names: Similarity
messages: Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

28892:METLI RS04780
gene id: 28892:METLI_RS04780
uniprot id: J1L1N1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS00590
gene id: 28892:METLI_RS00590
uniprot id: J0RX48
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.
messages: Cell membrane
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Requires K(+) for maximal activity.
messages: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.

28892:METLI RS07920
gene id: 28892:METLI_RS07920
uniprot id: J1ARD4
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

28892:METLI RS07650
gene id: 28892:METLI_RS07650
uniprot id: J0SA10
names: Similarity
messages: Belongs to the UPF0285 family.

28892:METLI RS11020
gene id: 28892:METLI_RS11020
uniprot id: J0SBP2
names: Function
names: Similarity
messages: Belongs to the CDC6/cdc18 family.
messages: Involved in regulation of DNA replication.

28892:METLI RS05590
gene id: 28892:METLI_RS05590
uniprot id: J0RZS7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
messages: Binds 1 FMN per subunit.
messages: Catalyzes the conversion of dihydroorotate to orotate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS11780
gene id: 28892:METLI_RS11780
uniprot id: J1L5A7
names: Similarity
messages: Belongs to the UPF0305 family.

28892:METLI RS05865
gene id: 28892:METLI_RS05865
uniprot id: J1L275
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

28892:METLI RS05710
gene id: 28892:METLI_RS05710
uniprot id: J1L318
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

28892:METLI RS05465
gene id: 28892:METLI_RS05465
uniprot id: J0RZQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

28892:METLI RS09165
gene id: 28892:METLI_RS09165
uniprot id: J1ARX4
names: Function
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane
messages: Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.

28892:METLI RS07665
gene id: 28892:METLI_RS07665
uniprot id: J1L353
names: Function
names: Similarity
messages: Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

28892:METLI RS11315
gene id: 28892:METLI_RS11315
uniprot id: J0SBU9
names: Similarity
messages: Belongs to the radical SAM superfamily. KamA family.

28892:METLI RS09440
gene id: 28892:METLI_RS09440
uniprot id: J0SAZ0
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

28892:METLI RS10330
gene id: 28892:METLI_RS10330
uniprot id: J0S2A0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

28892:METLI RS08920
gene id: 28892:METLI_RS08920
uniprot id: J1ART2
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS05490
gene id: 28892:METLI_RS05490
uniprot id: J0RZR1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the imidazoleglycerol-phosphate dehydratase family.
messages: Cytoplasm

28892:METLI RS09630
gene id: 28892:METLI_RS09630
uniprot id: J1L480
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL42 family.
messages: Binds 1 zinc ion per subunit.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

28892:METLI RS09805
gene id: 28892:METLI_RS09805
uniprot id: J0SB41
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Part of the RNA polymerase complex.

28892:METLI RS10150
gene id: 28892:METLI_RS10150
uniprot id: J0SB93
names: Similarity
messages: Belongs to the TCP-1 chaperonin family.

28892:METLI RS02445
gene id: 28892:METLI_RS02445
uniprot id: J1ANM5
names: Subunit
messages: MCR is composed of three subunits: alpha, beta, and gamma. The function of proteins C and D is not known.

28892:METLI RS10735
gene id: 28892:METLI_RS10735
uniprot id: J0S2G6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the CRISPR-associated exonuclease Cas4 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
messages: Mg(2+) or Mn(2+) required for ssDNA cleavage activity.

28892:METLI RS02545
gene id: 28892:METLI_RS02545
uniprot id: J0S7H7
names: Similarity
messages: Belongs to the LeuD family. LeuD type 2 subfamily.

28892:METLI RS07205
gene id: 28892:METLI_RS07205
uniprot id: J1L3X6
names: Function
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.

28892:METLI RS03040
gene id: 28892:METLI_RS03040
uniprot id: J0RYF2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the isopentenyl phosphate kinase family.
messages: Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
messages: Homodimer.

28892:METLI RS05915
gene id: 28892:METLI_RS05915
uniprot id: J1AQB6
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the eukaryotic release factor 1 family. Pelota subfamily.
messages: Cytoplasm
messages: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.
messages: Monomer.
messages: The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.

28892:METLI RS06215
gene id: 28892:METLI_RS06215
uniprot id: J1L2D6
names: Similarity
messages: Belongs to the HypD family.

28892:METLI RS00570
gene id: 28892:METLI_RS00570
uniprot id: J1KZD8
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS01330
gene id: 28892:METLI_RS01330
uniprot id: J1KZR3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

28892:METLI RS06960
gene id: 28892:METLI_RS06960
uniprot id: J1L3T8
names: Similarity
messages: Belongs to the IMPACT family.

28892:METLI RS07460
gene id: 28892:METLI_RS07460
uniprot id: J0S0T2
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

28892:METLI RS02210
gene id: 28892:METLI_RS02210
uniprot id: J0S7B4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head.
messages: Part of the 30S ribosomal subunit.

28892:METLI RS11435
gene id: 28892:METLI_RS11435
uniprot id: J1L533
names: Similarity
messages: Belongs to the pterin-4-alpha-carbinolamine dehydratase family.

28892:METLI RS01100
gene id: 28892:METLI_RS01100
uniprot id: J1L0Q0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

28892:METLI RS01120
gene id: 28892:METLI_RS01120
uniprot id: J0S6P4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

28892:METLI RS02385
gene id: 28892:METLI_RS02385
uniprot id: J1L1D1
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS03330
gene id: 28892:METLI_RS03330
uniprot id: J1L0V8
names: Similarity
messages: Belongs to the SIS family. PHI subfamily.

28892:METLI RS10400
gene id: 28892:METLI_RS10400
uniprot id: J1L5G9
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eS8 family.
messages: Part of the 30S ribosomal subunit.

28892:METLI RS09830
gene id: 28892:METLI_RS09830
uniprot id: J0SB45
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Participates in transcription termination.

28892:METLI RS06345
gene id: 28892:METLI_RS06345
uniprot id: J1L2F4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS10580
gene id: 28892:METLI_RS10580
uniprot id: J0SBG5
names: Function
names: Similarity
messages: Belongs to the archaeal 6-HMPDK family.
messages: Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).

28892:METLI RS08840
gene id: 28892:METLI_RS08840
uniprot id: J1L3Q2
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS09730
gene id: 28892:METLI_RS09730
uniprot id: J1L493
names: Similarity
messages: Belongs to the band 7/mec-2 family.

28892:METLI RS06675
gene id: 28892:METLI_RS06675
uniprot id: J0S9K2
names: Function
names: Similarity
messages: Belongs to the DNA mismatch repair MutL/HexB family.
messages: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.

28892:METLI RS09905
gene id: 28892:METLI_RS09905
uniprot id: J0SB54
names: Function
names: Similarity
messages: Belongs to the 2H phosphoesterase superfamily. ThpR family.
messages: Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.

28892:METLI RS11595
gene id: 28892:METLI_RS11595
uniprot id: J1L634
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the shikimate dehydrogenase family.
messages: Homodimer.
messages: Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS03230
gene id: 28892:METLI_RS03230
uniprot id: J1ANY5
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS10425
gene id: 28892:METLI_RS10425
uniprot id: J1L5H3
names: Function
names: Similarity
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.

28892:METLI RS04365
gene id: 28892:METLI_RS04365
uniprot id: J1L2H1
names: Similarity
messages: Belongs to the peptidase M20A family.

28892:METLI RS05100
gene id: 28892:METLI_RS05100
uniprot id: J1L2S1
names: Caution
names: Function
names: Similarity
messages: Belongs to the TBP family.
messages: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS09470
gene id: 28892:METLI_RS09470
uniprot id: J1L530
names: Similarity
messages: Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.

28892:METLI RS07770
gene id: 28892:METLI_RS07770
uniprot id: J1L368
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS10630
gene id: 28892:METLI_RS10630
uniprot id: J0SBH4
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DtdA deacylase family.
messages: Binds 2 Zn(2+) ions per subunit.
messages: D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.
messages: Monomer.

28892:METLI RS01845
gene id: 28892:METLI_RS01845
uniprot id: J0RXX0
names: Similarity
messages: Belongs to the LarC family.

28892:METLI RS07945
gene id: 28892:METLI_RS07945
uniprot id: J1ARD7
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS06505
gene id: 28892:METLI_RS06505
uniprot id: J1L2I1
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS07090
gene id: 28892:METLI_RS07090
uniprot id: J1L2V4
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS10280
gene id: 28892:METLI_RS10280
uniprot id: J0S291
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS10245
gene id: 28892:METLI_RS10245
uniprot id: J0SBB0
names: Function
names: Similarity
messages: Belongs to the V-ATPase V0D/AC39 subunit family.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

28892:METLI RS00315
gene id: 28892:METLI_RS00315
uniprot id: J0RWZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the TrpA family.
messages: Tetramer of two alpha and two beta chains.
messages: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.

28892:METLI RS08600
gene id: 28892:METLI_RS08600
uniprot id: J0S1C4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm

28892:METLI RS09390
gene id: 28892:METLI_RS09390
uniprot id: J0SAY4
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS08965
gene id: 28892:METLI_RS08965
uniprot id: J1ARU0
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL20 family.
messages: Part of the 50S ribosomal subunit. Binds 23S rRNA.

28892:METLI RS05680
gene id: 28892:METLI_RS05680
uniprot id: J0S926
names: Similarity
names: Subunit
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
messages: Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.

28892:METLI RS08970
gene id: 28892:METLI_RS08970
uniprot id: J0SAP1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prefoldin alpha subunit family.
messages: Belongs to the prefoldin subunit alpha family.
messages: Cytoplasm
messages: Heterohexamer of two alpha and four beta subunits.
messages: Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.

28892:METLI RS00665
gene id: 28892:METLI_RS00665
uniprot id: J0RX63
names: Similarity
messages: Belongs to the MoaB/Mog family.

28892:METLI RS08105
gene id: 28892:METLI_RS08105
uniprot id: J0S142
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal dihydroneopterin aldolase family.
messages: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).
messages: Homotetramer.

28892:METLI RS08800
gene id: 28892:METLI_RS08800
uniprot id: J0SAL0
names: Similarity
messages: Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.

28892:METLI RS11590
gene id: 28892:METLI_RS11590
uniprot id: J0SC08
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

28892:METLI RS02695
gene id: 28892:METLI_RS02695
uniprot id: J0S7K4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HisA/HisF family.
messages: Cytoplasm
messages: Heterodimer of HisH and HisF.
messages: IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.

28892:METLI RS11715
gene id: 28892:METLI_RS11715
uniprot id: J0SC31
names: Similarity
messages: Belongs to the site-specific recombinase resolvase family.

28892:METLI RS10745
gene id: 28892:METLI_RS10745
uniprot id: J1ASR5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.

28892:METLI RS08505
gene id: 28892:METLI_RS08505
uniprot id: J1ARM1
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UMP kinase family.
messages: Catalyzes the reversible phosphorylation of UMP to UDP.
messages: Cytoplasm
messages: Homohexamer.
messages: Inhibited by UTP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS04705
gene id: 28892:METLI_RS04705
uniprot id: J1L1M0
names: Similarity
messages: Belongs to the TPP enzyme family.

28892:METLI RS06975
gene id: 28892:METLI_RS06975
uniprot id: J0S9Q4
names: Similarity
messages: Belongs to the CutA family.

28892:METLI RS04320
gene id: 28892:METLI_RS04320
uniprot id: J1L1G5
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS00325
gene id: 28892:METLI_RS00325
uniprot id: J1AMJ5
names: Similarity
messages: Belongs to the TrpF family.

28892:METLI RS02270
gene id: 28892:METLI_RS02270
uniprot id: J0RY32
names: Function
names: Similarity
names: Subunit
messages: Belongs to the eukaryotic ribosomal protein eL19 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

28892:METLI RS08140
gene id: 28892:METLI_RS08140
uniprot id: J1ARH1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal phosphopantothenate synthetase family.
messages: Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS06245
gene id: 28892:METLI_RS06245
uniprot id: J1AQH3
names: Similarity
messages: Belongs to the UPF0251 family.

28892:METLI RS02230
gene id: 28892:METLI_RS02230
uniprot id: J1ANJ7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.

28892:METLI RS06500
gene id: 28892:METLI_RS06500
uniprot id: J0S0A0
names: Similarity
messages: Belongs to the UPF0310 family.

28892:METLI RS07895
gene id: 28892:METLI_RS07895
uniprot id: J1ARC9
names: Similarity
messages: Belongs to the UPF0280 family.

28892:METLI RS01200
gene id: 28892:METLI_RS01200
uniprot id: J1AMZ8
names: Similarity
messages: Belongs to the FrhG family.

28892:METLI RS06790
gene id: 28892:METLI_RS06790
uniprot id: J1L3R1
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS11875
gene id: 28892:METLI_RS11875
uniprot id: J0S367
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.
messages: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
messages: Cytoplasm

28892:METLI RS10160
gene id: 28892:METLI_RS10160
uniprot id: J0S271
names: Similarity
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.

28892:METLI RS00110
gene id: 28892:METLI_RS00110
uniprot id: J1L061
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

28892:METLI RS02160
gene id: 28892:METLI_RS02160
uniprot id: J0S7A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the mer family.
messages: Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
messages: Cytoplasm

28892:METLI RS04305
gene id: 28892:METLI_RS04305
uniprot id: J0S8E3
names: Similarity
messages: Belongs to the AAA ATPase family. CDC48 subfamily.

28892:METLI RS11960
gene id: 28892:METLI_RS11960
uniprot id: J1ATC3
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the transcriptional regulatory CopG/NikR family.
messages: Binds 1 nickel ion per subunit.
messages: Transcriptional regulator.

28892:METLI RS01265
gene id: 28892:METLI_RS01265
uniprot id: J0RXG4
names: Similarity
messages: Belongs to the AAA ATPase family.

28892:METLI RS11995
gene id: 28892:METLI_RS11995
uniprot id: J0S388
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the protein kinase superfamily. BUD32 family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Component of the KEOPS complex that consists of Kae1, Bud32, Cgi121 and Pcc1; the whole complex dimerizes.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the protein kinase superfamily. Tyr protein kinase family. BUD32 subfamily.
messages: In the N-terminal section; belongs to the KAE1 / TsaD family.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function.

28892:METLI RS10650
gene id: 28892:METLI_RS10650
uniprot id: J1ASP6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

28892:METLI RS03845
gene id: 28892:METLI_RS03845
uniprot id: J0RYV0
names: Similarity
messages: Belongs to the UPF0175 family.

28892:METLI RS06695
gene id: 28892:METLI_RS06695
uniprot id: J1L2M2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Mediates influx of magnesium ions.
messages: Membrane

28892:METLI RS11545
gene id: 28892:METLI_RS11545
uniprot id: J1L624
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peroxiredoxin family. Prx6 subfamily.
messages: Cytoplasm
messages: Homodecamer. Pentamer of dimers that assemble into a ring structure.
messages: The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.
messages: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.

28892:METLI RS09490
gene id: 28892:METLI_RS09490
uniprot id: J0SAZ6
names: Similarity
messages: Belongs to the peptidase S49 family.

28892:METLI RS00140
gene id: 28892:METLI_RS00140
uniprot id: J0RWW0
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

28892:METLI RS00705
gene id: 28892:METLI_RS00705
uniprot id: J0S6H2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. Hel308 subfamily.
messages: DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.
messages: Monomer.

28892:METLI RS03530
gene id: 28892:METLI_RS03530
uniprot id: J1L1X6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HdrA family.
messages: Cytoplasm
messages: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
messages: The ferredoxin:CoB-CoM heterodisulfide reductase is composed of three subunits; HdrA, HdrB and HdrC.

28892:METLI RS09595
gene id: 28892:METLI_RS09595
uniprot id: J1L550
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycerol-1-phosphate dehydrogenase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS04650
gene id: 28892:METLI_RS04650
uniprot id: J0RZD4
names: Similarity
messages: Belongs to the precorrin methyltransferase family.

28892:METLI RS07620
gene id: 28892:METLI_RS07620
uniprot id: J1AR88
names: Subunit
messages: Heterotetramer of one alpha, one beta, one delta and one gamma chain.

28892:METLI RS11990
gene id: 28892:METLI_RS11990
uniprot id: J0SCA7
names: Similarity
messages: Belongs to the eukaryotic ribosomal protein eS24 family.

28892:METLI RS08215
gene id: 28892:METLI_RS08215
uniprot id: J1L3F1
names: Similarity
messages: Belongs to the HepT RNase toxin family.

28892:METLI RS11165
gene id: 28892:METLI_RS11165
uniprot id: J1L5U8
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: Potential transporter for phosphate.

28892:METLI RS01900
gene id: 28892:METLI_RS01900
uniprot id: J0RXY2
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS10325
gene id: 28892:METLI_RS10325
uniprot id: J1L5F7
names: Similarity
messages: Belongs to the archaeal-type GPI family.

28892:METLI RS05645
gene id: 28892:METLI_RS05645
uniprot id: J1L234
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.

28892:METLI RS09400
gene id: 28892:METLI_RS09400
uniprot id: J0S1V5
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS10555
gene id: 28892:METLI_RS10555
uniprot id: J1L5J4
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS00430
gene id: 28892:METLI_RS00430
uniprot id: J1AML6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Ni-containing carbon monoxide dehydrogenase family.
messages: CODH oxidizes carbon monoxide coupled, via CooF, to the reduction of a hydrogen cation by a hydrogenase (possibly CooH).
messages: Homodimer.

28892:METLI RS00545
gene id: 28892:METLI_RS00545
uniprot id: J1KZD5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. CofH family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
messages: The FO synthase complex consists of two subunits, CofG and CofH.

28892:METLI RS09275
gene id: 28892:METLI_RS09275
uniprot id: J1L4X0
names: Function
names: Similarity
messages: Belongs to the archaeal SPP-like hydrolase family.
messages: Catalyzes the dephosphorylation of 2-phosphoglycolate.

28892:METLI RS03660
gene id: 28892:METLI_RS03660
uniprot id: J1L200
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

28892:METLI RS09810
gene id: 28892:METLI_RS09810
uniprot id: J1L582
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Cytoplasm
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Part of the RNA polymerase complex.

28892:METLI RS00090
gene id: 28892:METLI_RS00090
uniprot id: J0RWV5
names: Caution
names: Function
names: Similarity
messages: Belongs to the tRNA pseudouridine synthase TruA family.
messages: Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

28892:METLI RS05720
gene id: 28892:METLI_RS05720
uniprot id: J1L248
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

28892:METLI RS11980
gene id: 28892:METLI_RS11980
uniprot id: J1L5H7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal Spt4 family.
messages: Heterodimer composed of Spt4 and Spt5.
messages: Stimulates transcription elongation.

28892:METLI RS03240
gene id: 28892:METLI_RS03240
uniprot id: J1L1R7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PRA-PH family.
messages: Cytoplasm

28892:METLI RS02305
gene id: 28892:METLI_RS02305
uniprot id: J1ANK6
names: Subcellular Location Annotation
messages: Membrane

28892:METLI RS01335
gene id: 28892:METLI_RS01335
uniprot id: J1AN21
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

28892:METLI RS00645
gene id: 28892:METLI_RS00645
uniprot id: J1KZF1
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

28892:METLI RS11725
gene id: 28892:METLI_RS11725
uniprot id: J0S305
names: Function
names: Similarity
messages: Belongs to the archaeal riboflavin kinase family.
messages: Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).

28892:METLI RS07350
gene id: 28892:METLI_RS07350
uniprot id: J1AR42
names: Subcellular Location Annotation
messages: Cell membrane
messages: Membrane

28892:METLI RS01105
gene id: 28892:METLI_RS01105
uniprot id: J0RXD4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the archaeal DNA polymerase II family.
messages: Heterodimer of a large subunit and a small subunit.
messages: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.

28892:METLI RS01710
gene id: 28892:METLI_RS01710
uniprot id: J0S727
names: Cofactor
messages: Binds 1 zinc ion per subunit.

28892:METLI RS03100
gene id: 28892:METLI_RS03100
uniprot id: J1ANW7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

28892:METLI RS04170
gene id: 28892:METLI_RS04170
uniprot id: J1L1B4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

28892:METLI RS09255
gene id: 28892:METLI_RS09255
uniprot id: J0S1P9
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

28892:METLI RS01300
gene id: 28892:METLI_RS01300
uniprot id: J1KZR0
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

28892:METLI RS05595
gene id: 28892:METLI_RS05595
uniprot id: J1L225
names: Cofactor
messages: Binds 1 [2Fe-2S] cluster per subunit.

28892:METLI RS10170
gene id: 28892:METLI_RS10170
uniprot id: J1ASG7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.
messages: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
messages: Cytoplasm

28892:METLI RS07300
gene id: 28892:METLI_RS07300
uniprot id: J1AR33
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-I family.