222136:BBW65 RS04860
gene id: 222136:BBW65_RS04860
uniprot id: A0A1B1U5Z1
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MsrP family.
messages: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.
messages: Heterodimer of a catalytic subunit (MsrP) and a heme-binding subunit (MsrQ).
messages: Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide.

222136:BBW65 RS03540
gene id: 222136:BBW65_RS03540
uniprot id: A0A1B1U597
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 2 family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

222136:BBW65 RS06880
gene id: 222136:BBW65_RS06880
uniprot id: A0A1B1U6W2
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum
messages: Belongs to the flagella basal body rod proteins family.
messages: Secreted

222136:BBW65 RS01910
gene id: 222136:BBW65_RS01910
uniprot id: A0A1B1U4F5
names: Subcellular Location Annotation
messages: Membrane

222136:BBW65 RS02060
gene id: 222136:BBW65_RS02060
uniprot id: A0A1B1U4M8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A monovalent cation. Ammonium or potassium.
messages: Belongs to the type III pantothenate kinase family.
messages: Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
messages: Cytoplasm
messages: Homodimer.

222136:BBW65 RS02020
gene id: 222136:BBW65_RS02020
uniprot id: A0A1B1U4H5
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily.
messages: Binds 2 Zn(2+) ions per subunit.
messages: Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS01735
gene id: 222136:BBW65_RS01735
uniprot id: A0A1B1U7K0
names: Similarity
messages: Belongs to the helicase family. RecG subfamily.

222136:BBW65 RS03420
gene id: 222136:BBW65_RS03420
uniprot id: A0A1B1U5E0
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

222136:BBW65 RS02290
gene id: 222136:BBW65_RS02290
uniprot id: A0A1B1U4I0
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS20 family.
messages: Binds directly to 16S ribosomal RNA.

222136:BBW65 RS03255
gene id: 222136:BBW65_RS03255
uniprot id: A0A1B1U545
names: Similarity
messages: Belongs to the threonine synthase family.

222136:BBW65 RS05050
gene id: 222136:BBW65_RS05050
uniprot id: A0A1B1U5X8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

222136:BBW65 RS04995
gene id: 222136:BBW65_RS04995
uniprot id: A0A1B1U5Y5
names: Similarity
messages: Belongs to the DprA/Smf family.

222136:BBW65 RS07420
gene id: 222136:BBW65_RS07420
uniprot id: A0A1B1U7B8
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
messages: DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS04195
gene id: 222136:BBW65_RS04195
uniprot id: A0A1B1U7P5
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase large chain family.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

222136:BBW65 RS05415
gene id: 222136:BBW65_RS05415
uniprot id: A0A1B1U681
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecY/SEC61-alpha family.
messages: Cell membrane
messages: Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

222136:BBW65 RS02995
gene id: 222136:BBW65_RS02995
uniprot id: A0A1B1U7I2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
messages: Belongs to the FliW family.
messages: Cytoplasm
messages: Interacts with translational regulator CsrA and flagellin(s).

222136:BBW65 RS04200
gene id: 222136:BBW65_RS04200
uniprot id: A0A1B1U5P6
names: Similarity
messages: Belongs to the nitroreductase family.

222136:BBW65 RS02175
gene id: 222136:BBW65_RS02175
uniprot id: A0A1B1U4G1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.
messages: Secreted

222136:BBW65 RS01165
gene id: 222136:BBW65_RS01165
uniprot id: A0A1B1U482
names: Subcellular Location Annotation
messages: Membrane

222136:BBW65 RS02050
gene id: 222136:BBW65_RS02050
uniprot id: A0A1B1U4H7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gmhB family.
messages: Cytoplasm

222136:BBW65 RS00170
gene id: 222136:BBW65_RS00170
uniprot id: A0A1B1U3J8
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

222136:BBW65 RS06825
gene id: 222136:BBW65_RS06825
uniprot id: A0A1B1U6V2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GrpE family.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

222136:BBW65 RS07620
gene id: 222136:BBW65_RS07620
uniprot id: A0A1B1U7G3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transaldolase family. Type 2 subfamily.
messages: Cytoplasm
messages: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

222136:BBW65 RS02260
gene id: 222136:BBW65_RS02260
uniprot id: A0A1B1U4M5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

222136:BBW65 RS04525
gene id: 222136:BBW65_RS04525
uniprot id: A0A1B1U5T4
names: Similarity
messages: Belongs to the RutC family.

222136:BBW65 RS05410
gene id: 222136:BBW65_RS05410
uniprot id: A0A1B1U686
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

222136:BBW65 RS02590
gene id: 222136:BBW65_RS02590
uniprot id: A0A1B1U4S4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the Nth/MutY family.
messages: Binds 1 [4Fe-4S] cluster.
messages: DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

222136:BBW65 RS01035
gene id: 222136:BBW65_RS01035
uniprot id: A0A1B1U3Z5
names: Domain
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the glutamyl-tRNA reductase family.
messages: Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
messages: During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.
messages: Homodimer.
messages: Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.

222136:BBW65 RS05060
gene id: 222136:BBW65_RS05060
uniprot id: A0A1B1U623
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

222136:BBW65 RS05350
gene id: 222136:BBW65_RS05350
uniprot id: A0A1B1U685
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

222136:BBW65 RS00485
gene id: 222136:BBW65_RS00485
uniprot id: A0A1B1U3P1
names: Subcellular Location Annotation
messages: Membrane

222136:BBW65 RS00905
gene id: 222136:BBW65_RS00905
uniprot id: A0A1B1U3W9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliQ/MopD/SpaQ family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

222136:BBW65 RS02810
gene id: 222136:BBW65_RS02810
uniprot id: A0A1B1U4X0
names: Similarity
messages: Belongs to the asparaginase 1 family.

222136:BBW65 RS06250
gene id: 222136:BBW65_RS06250
uniprot id: A0A1B1U6Q0
names: Subcellular Location Annotation
messages: Membrane

222136:BBW65 RS04180
gene id: 222136:BBW65_RS04180
uniprot id: A0A1B1U7M0
names: Similarity
messages: Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.

222136:BBW65 RS07490
gene id: 222136:BBW65_RS07490
uniprot id: A0A1B1U7D0
names: Caution
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnD subfamily.
messages: Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS05360
gene id: 222136:BBW65_RS05360
uniprot id: A0A1B1U675
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

222136:BBW65 RS02385
gene id: 222136:BBW65_RS02385
uniprot id: A0A1B1U4U0
names: Similarity
messages: Belongs to the phosphate acetyltransferase and butyryltransferase family.

222136:BBW65 RS03765
gene id: 222136:BBW65_RS03765
uniprot id: A0A1B1U5D7
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
messages: Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
messages: Cytoplasm
messages: Monomer.
messages: The C-terminal coiled-coil domain is crucial for aminoacylation activity.
messages: ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.

222136:BBW65 RS06455
gene id: 222136:BBW65_RS06455
uniprot id: A0A1B1U6S0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase epsilon chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane.

222136:BBW65 RS02670
gene id: 222136:BBW65_RS02670
uniprot id: A0A1B1U4V7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane
messages: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.

222136:BBW65 RS02770
gene id: 222136:BBW65_RS02770
uniprot id: A0A1B1U4V9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.
messages: Cytoplasm
messages: Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

222136:BBW65 RS02845
gene id: 222136:BBW65_RS02845
uniprot id: A0A1B1U541
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.
messages: Membrane
messages: The accessory proteins ExbB and ExbD seem to form a complex with TonB.

222136:BBW65 RS05355
gene id: 222136:BBW65_RS05355
uniprot id: A0A1B1U637
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

222136:BBW65 RS04375
gene id: 222136:BBW65_RS04375
uniprot id: A0A1B1U5S6
names: Similarity
messages: Belongs to the homoserine dehydrogenase family.

222136:BBW65 RS02350
gene id: 222136:BBW65_RS02350
uniprot id: A0A1B1U4N3
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
messages: Belongs to the amidase family. GatA subfamily.
messages: Heterotrimer of A, B and C subunits.

222136:BBW65 RS06945
gene id: 222136:BBW65_RS06945
uniprot id: A0A1B1U781
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

222136:BBW65 RS06705
gene id: 222136:BBW65_RS06705
uniprot id: A0A1B1U6Y2
names: Function
names: Similarity
messages: Belongs to the thymidylate kinase family.
messages: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.

222136:BBW65 RS07310
gene id: 222136:BBW65_RS07310
uniprot id: A0A1B1U7G4
names: Subcellular Location Annotation
messages: Membrane

222136:BBW65 RS04640
gene id: 222136:BBW65_RS04640
uniprot id: A0A1B1U5V2
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. MoaA family.
messages: Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.
messages: Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
messages: Monomer and homodimer.

222136:BBW65 RS00270
gene id: 222136:BBW65_RS00270
uniprot id: A0A1B1U3M5
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

222136:BBW65 RS02615
gene id: 222136:BBW65_RS02615
uniprot id: A0A1B1U4U7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.
messages: Cytoplasm
messages: In the C-terminal section; belongs to the helicase family. RecG subfamily.
messages: In the N-terminal section; belongs to the UvrB family.

222136:BBW65 RS04580
gene id: 222136:BBW65_RS04580
uniprot id: A0A1B1U5T3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.
messages: Catalyzes the sodium-dependent transport of glutamate.
messages: Cell membrane

222136:BBW65 RS01485
gene id: 222136:BBW65_RS01485
uniprot id: A0A1B1U479
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS05025
gene id: 222136:BBW65_RS05025
uniprot id: A0A1B1U615
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

222136:BBW65 RS07500
gene id: 222136:BBW65_RS07500
uniprot id: A0A1B1U7I0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

222136:BBW65 RS06805
gene id: 222136:BBW65_RS06805
uniprot id: A0A1B1U703
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the AdoMet synthase family.
messages: Binds 1 potassium ion per subunit.
messages: Binds 2 divalent ions per subunit.
messages: Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS06795
gene id: 222136:BBW65_RS06795
uniprot id: A0A1B1U6X8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NDK family.
messages: Cytoplasm
messages: Homotetramer.
messages: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.

222136:BBW65 RS04585
gene id: 222136:BBW65_RS04585
uniprot id: A0A1B1U5U3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family. SRP54 subfamily.
messages: Cytoplasm

222136:BBW65 RS04660
gene id: 222136:BBW65_RS04660
uniprot id: A0A1B1U5Q8
names: Similarity
messages: Belongs to the class-I fumarase family.

222136:BBW65 RS05875
gene id: 222136:BBW65_RS05875
uniprot id: A0A1B1U7W6
names: Similarity
names: Subunit
messages: Belongs to the RNase H family.
messages: Monomer.

222136:BBW65 RS01420
gene id: 222136:BBW65_RS01420
uniprot id: A0A1B1U468
names: Function
names: Similarity
messages: Belongs to the cyclophilin-type PPIase family.
messages: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

222136:BBW65 RS04870
gene id: 222136:BBW65_RS04870
uniprot id: A0A1B1U645
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nicotinamide ribonucleoside (NR) uptake permease (TC 4.B.1) family.
messages: Membrane

222136:BBW65 RS01280
gene id: 222136:BBW65_RS01280
uniprot id: A0A1B1U475
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmH family.
messages: Cytoplasm
messages: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.

222136:BBW65 RS00450
gene id: 222136:BBW65_RS00450
uniprot id: A0A1B1U3Q7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SurE nucleotidase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Cytoplasm
messages: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.

222136:BBW65 RS00145
gene id: 222136:BBW65_RS00145
uniprot id: A0A1B1U3I8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. Important for motility and virulence.
messages: Heteromer of FlaA and FlaB. FlaB is located proximal to the hook while the remainder of the filament is composed of the predominant FlaA.
messages: Secreted

222136:BBW65 RS00360
gene id: 222136:BBW65_RS00360
uniprot id: A0A1B1U3N6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family. DXPS subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
messages: Homodimer.

222136:BBW65 RS00660
gene id: 222136:BBW65_RS00660
uniprot id: A0A1B1U3R5
names: Function
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: The fumarate reductase enzyme complex is required for fumarate respiration. This subunit anchors the complex in the membrane and binds a diheme cytochrome b.

222136:BBW65 RS00325
gene id: 222136:BBW65_RS00325
uniprot id: A0A1B1U3N2
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

222136:BBW65 RS01655
gene id: 222136:BBW65_RS01655
uniprot id: A0A1B1U4B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum
messages: Belongs to the bacterial flagellin family.
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. Important for motility and virulence.
messages: Heteromer of FlaA and FlaB. FlaB is located proximal to the hook while the remainder of the filament is composed of the predominant FlaA.
messages: Secreted

222136:BBW65 RS01990
gene id: 222136:BBW65_RS01990
uniprot id: A0A1B1U4I7
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

222136:BBW65 RS03795
gene id: 222136:BBW65_RS03795
uniprot id: A0A1B1U5C6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the endoribonuclease YbeY family.
messages: Binds 1 zinc ion.
messages: Cytoplasm
messages: Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.

222136:BBW65 RS04530
gene id: 222136:BBW65_RS04530
uniprot id: A0A1B1U5V7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methylthiotransferase family. RimO subfamily.
messages: Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein uS12.
messages: Cytoplasm

222136:BBW65 RS06920
gene id: 222136:BBW65_RS06920
uniprot id: A0A1B1U742
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS21 family.

222136:BBW65 RS01700
gene id: 222136:BBW65_RS01700
uniprot id: A0A1B1U4C5
names: Subcellular Location Annotation
messages: Membrane

222136:BBW65 RS06385
gene id: 222136:BBW65_RS06385
uniprot id: A0A1B1U6Y5
names: Function
names: Subunit
messages: Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. Important for motility and virulence.
messages: Heteromer of FlaA and FlaB. FlaB is located proximal to the hook while the remainder of the filament is composed of the predominant FlaA.

222136:BBW65 RS04275
gene id: 222136:BBW65_RS04275
uniprot id: A0A1B1U5M9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase beta chain family.
messages: Belongs to the RNA polymerase beta' chain family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 2 Zn(2+) ions per subunit.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: In the C-terminal section; belongs to the RNA polymerase beta' chain family.
messages: In the N-terminal section; belongs to the RNA polymerase beta chain family.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

222136:BBW65 RS02830
gene id: 222136:BBW65_RS02830
uniprot id: A0A1B1U522
names: Similarity
names: Subunit
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

222136:BBW65 RS07165
gene id: 222136:BBW65_RS07165
uniprot id: A0A1B1U769
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

222136:BBW65 RS00920
gene id: 222136:BBW65_RS00920
uniprot id: A0A1B1U3X6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspG family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.

222136:BBW65 RS06245
gene id: 222136:BBW65_RS06245
uniprot id: A0A1B1U6N4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
messages: Cytoplasm
messages: Homotrimer.
messages: In the C-terminal section; belongs to the transferase hexapeptide repeat family.
messages: In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS02965
gene id: 222136:BBW65_RS02965
uniprot id: A0A1B1U4W3
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

222136:BBW65 RS06210
gene id: 222136:BBW65_RS06210
uniprot id: A0A1B1U6U6
names: Function
names: Similarity
messages: Belongs to the MqnA/MqnD family. MqnA subfamily.
messages: Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).

222136:BBW65 RS07485
gene id: 222136:BBW65_RS07485
uniprot id: A0A1B1U7A0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

222136:BBW65 RS00380
gene id: 222136:BBW65_RS00380
uniprot id: A0A1B1U3N8
names: Function
names: Similarity
messages: Belongs to the carbohydrate kinase PfkB family.
messages: Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.

222136:BBW65 RS03495
gene id: 222136:BBW65_RS03495
uniprot id: A0A1B1U589
names: Function
names: Similarity
messages: Belongs to the dus family.
messages: Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.

222136:BBW65 RS07715
gene id: 222136:BBW65_RS07715
uniprot id: A0A1B1U7E3
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

222136:BBW65 RS04155
gene id: 222136:BBW65_RS04155
uniprot id: A0A1B1U5H0
names: Caution
names: Function
names: Similarity
messages: Belongs to the GART family.
messages: Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS04140
gene id: 222136:BBW65_RS04140
uniprot id: A0A1B1U5N7
names: Similarity
messages: Belongs to the SAICAR synthetase family.

222136:BBW65 RS02220
gene id: 222136:BBW65_RS02220
uniprot id: A0A1B1U4M6
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
messages: Cytoplasm
messages: Homodimer.

222136:BBW65 RS04170
gene id: 222136:BBW65_RS04170
uniprot id: A0A1B1U5H7
names: Similarity
messages: Belongs to the GARS family.

222136:BBW65 RS00900
gene id: 222136:BBW65_RS00900
uniprot id: A0A1B1U7J1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.
messages: Membrane

222136:BBW65 RS06285
gene id: 222136:BBW65_RS06285
uniprot id: A0A1B1U6K2
names: Similarity
messages: Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.

222136:BBW65 RS00670
gene id: 222136:BBW65_RS00670
uniprot id: A0A1B1U3T8
names: Cofactor
names: Similarity
messages: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
messages: Binds 1 [2Fe-2S] cluster.
messages: Binds 1 [3Fe-4S] cluster.
messages: Binds 1 [4Fe-4S] cluster.

222136:BBW65 RS06615
gene id: 222136:BBW65_RS06615
uniprot id: A0A1B1U6U9
names: Subcellular Location Annotation
messages: Cytoplasm

222136:BBW65 RS06670
gene id: 222136:BBW65_RS06670
uniprot id: A0A1B1U6R7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas1 homodimer.

222136:BBW65 RS00180
gene id: 222136:BBW65_RS00180
uniprot id: A0A1B1U3I4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0718 family.
messages: Cell membrane
messages: Membrane

222136:BBW65 RS01330
gene id: 222136:BBW65_RS01330
uniprot id: A0A1B1U465
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the radical SAM superfamily. Biotin synthase family.
messages: Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS07300
gene id: 222136:BBW65_RS07300
uniprot id: A0A1B1U760
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 3 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homodimer.

222136:BBW65 RS06380
gene id: 222136:BBW65_RS06380
uniprot id: A0A1B1U6M3
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS05450
gene id: 222136:BBW65_RS05450
uniprot id: A0A1B1U6A7
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

222136:BBW65 RS02470
gene id: 222136:BBW65_RS02470
uniprot id: A0A1B1U4R1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TACO1 family.
messages: Cytoplasm

222136:BBW65 RS00840
gene id: 222136:BBW65_RS00840
uniprot id: A0A1B1U3W6
names: Similarity
messages: Belongs to the glutamine synthetase family.

222136:BBW65 RS05405
gene id: 222136:BBW65_RS05405
uniprot id: A0A1B1U644
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

222136:BBW65 RS03690
gene id: 222136:BBW65_RS03690
uniprot id: A0A1B1U5I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M50B family.
messages: Membrane

222136:BBW65 RS00910
gene id: 222136:BBW65_RS00910
uniprot id: A0A1B1U3Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurB family.
messages: Cell wall formation.
messages: Cytoplasm

222136:BBW65 RS05160
gene id: 222136:BBW65_RS05160
uniprot id: A0A1B1U6B3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

222136:BBW65 RS06685
gene id: 222136:BBW65_RS06685
uniprot id: A0A1B1U7R5
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

222136:BBW65 RS03145
gene id: 222136:BBW65_RS03145
uniprot id: A0A1B1U525
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the OmpP1/FadL family.
messages: Cell outer membrane
messages: Membrane

222136:BBW65 RS03425
gene id: 222136:BBW65_RS03425
uniprot id: A0A1B1U572
names: Subcellular Location Annotation
messages: Membrane

222136:BBW65 RS08105
gene id: 222136:BBW65_RS08105
uniprot id: A0A1B1U625
names: Subcellular Location Annotation
messages: Membrane

222136:BBW65 RS07350
gene id: 222136:BBW65_RS07350
uniprot id: A0A1B1U771
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS07205
gene id: 222136:BBW65_RS07205
uniprot id: A0A1B1U731
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNase Y family.
messages: Cell membrane
messages: Endoribonuclease that initiates mRNA decay.

222136:BBW65 RS01905
gene id: 222136:BBW65_RS01905
uniprot id: A0A1B1U4L3
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HAM1 NTPase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

222136:BBW65 RS02285
gene id: 222136:BBW65_RS02285
uniprot id: A0A1B1U4K8
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

222136:BBW65 RS02790
gene id: 222136:BBW65_RS02790
uniprot id: A0A1B1U4S0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the EPSP synthase family.
messages: Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

222136:BBW65 RS02835
gene id: 222136:BBW65_RS02835
uniprot id: A0A1B1U4V5
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

222136:BBW65 RS04700
gene id: 222136:BBW65_RS04700
uniprot id: A0A1B1U5Y6
names: Similarity
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

222136:BBW65 RS05345
gene id: 222136:BBW65_RS05345
uniprot id: A0A1B1U6E2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

222136:BBW65 RS03430
gene id: 222136:BBW65_RS03430
uniprot id: A0A1B1U537
names: Similarity
messages: Belongs to the fabD family.

222136:BBW65 RS00105
gene id: 222136:BBW65_RS00105
uniprot id: A0A1B1U7G9
names: Similarity
messages: Belongs to the GPI family.

222136:BBW65 RS06900
gene id: 222136:BBW65_RS06900
uniprot id: A0A1B1U6Z7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

222136:BBW65 RS02115
gene id: 222136:BBW65_RS02115
uniprot id: A0A1B1U4I1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the KAE1 / TsaD family.
messages: Binds 1 Fe(2+) ion per subunit.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.

222136:BBW65 RS01995
gene id: 222136:BBW65_RS01995
uniprot id: A0A1B1U4L4
names: Cofactor
names: Function
names: Similarity
messages: Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Binds 1 potassium ion per subunit.
messages: In the C-terminal section; belongs to the NnrD/CARKD family.
messages: In the N-terminal section; belongs to the NnrE/AIBP family.

222136:BBW65 RS03665
gene id: 222136:BBW65_RS03665
uniprot id: A0A1B1U5B7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the QueA family.
messages: Cytoplasm
messages: Monomer.
messages: Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).

222136:BBW65 RS01825
gene id: 222136:BBW65_RS01825
uniprot id: A0A1B1U4E6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

222136:BBW65 RS06190
gene id: 222136:BBW65_RS06190
uniprot id: A0A1B1U6L9
names: Similarity
messages: Belongs to the CvfB family.

222136:BBW65 RS03685
gene id: 222136:BBW65_RS03685
uniprot id: A0A1B1U580
names: Function
names: Similarity
messages: Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
messages: Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.

222136:BBW65 RS01375
gene id: 222136:BBW65_RS01375
uniprot id: A0A1B1U453
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 'phage' integrase family. XerH subfamily.
messages: Cytoplasm
messages: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.

222136:BBW65 RS04915
gene id: 222136:BBW65_RS04915
uniprot id: A0A1B1U629
names: Function
names: Similarity
messages: Belongs to the DNA polymerase type-A family.
messages: In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.

222136:BBW65 RS02850
gene id: 222136:BBW65_RS02850
uniprot id: A0A1B1U4X4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

222136:BBW65 RS03165
gene id: 222136:BBW65_RS03165
uniprot id: A0A1B1U586
names: Similarity
messages: Belongs to the UPF0045 family.

222136:BBW65 RS07445
gene id: 222136:BBW65_RS07445
uniprot id: A0A1B1U7D7
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

222136:BBW65 RS02200
gene id: 222136:BBW65_RS02200
uniprot id: A0A1B1U4H4
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliE family.

222136:BBW65 RS02310
gene id: 222136:BBW65_RS02310
uniprot id: A0A1B1U4N1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the topoisomerase GyrA/ParC subunit family.
messages: Belongs to the type II topoisomerase GyrA/ParC subunit family.
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

222136:BBW65 RS03655
gene id: 222136:BBW65_RS03655
uniprot id: A0A1B1U5C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TatB family.
messages: Cell membrane

222136:BBW65 RS04500
gene id: 222136:BBW65_RS04500
uniprot id: A0A1B1U5Y7
names: Cofactor
names: Similarity
messages: Belongs to the CcoP / FixP family.
messages: Binds 2 heme C groups per subunit.

222136:BBW65 RS03720
gene id: 222136:BBW65_RS03720
uniprot id: A0A1B1U5C9
names: Function
names: PTM
names: Similarity
messages: An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.
messages: Belongs to the polyphosphate kinase 1 (PPK1) family.
messages: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).

222136:BBW65 RS06160
gene id: 222136:BBW65_RS06160
uniprot id: A0A1B1U6T0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Lgt family.
messages: Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
messages: Cell membrane

222136:BBW65 RS00985
gene id: 222136:BBW65_RS00985
uniprot id: A0A1B1U3W2
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

222136:BBW65 RS01300
gene id: 222136:BBW65_RS01300
uniprot id: A0A1B1U498
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

222136:BBW65 RS06565
gene id: 222136:BBW65_RS06565
uniprot id: A0A1B1U6V9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes.
messages: Belongs to the Fur family.
messages: Binds 1 Mn(2+) or Fe(2+) ion per subunit.
messages: Binds 1 zinc ion per subunit.
messages: Homodimer.

222136:BBW65 RS07305
gene id: 222136:BBW65_RS07305
uniprot id: A0A1B1U747
names: Subcellular Location Annotation
messages: Membrane

222136:BBW65 RS04115
gene id: 222136:BBW65_RS04115
uniprot id: A0A1B1U5J6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DHBP synthase family.
messages: Binds 2 divalent metal cations per subunit. Magnesium or manganese.
messages: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the GTP cyclohydrolase II family.
messages: In the N-terminal section; belongs to the DHBP synthase family.

222136:BBW65 RS02025
gene id: 222136:BBW65_RS02025
uniprot id: A0A1B1U4E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.
messages: Secreted

222136:BBW65 RS00480
gene id: 222136:BBW65_RS00480
uniprot id: A0A1B1U3Q6
names: Subcellular Location Annotation
messages: Membrane

222136:BBW65 RS06665
gene id: 222136:BBW65_RS06665
uniprot id: A0A1B1U6R9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the CRISPR-associated endonuclease Cas1 family.
messages: CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
messages: Homodimer, forms a heterotetramer with a Cas2 homodimer.

222136:BBW65 RS05370
gene id: 222136:BBW65_RS05370
uniprot id: A0A1B1U687
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

222136:BBW65 RS04715
gene id: 222136:BBW65_RS04715
uniprot id: A0A1B1U5R8
names: Similarity
messages: Belongs to the bacterial solute-binding protein 9 family.

222136:BBW65 RS01565
gene id: 222136:BBW65_RS01565
uniprot id: A0A1B1U4E1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.
messages: Homodimer.
messages: Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.

222136:BBW65 RS02075
gene id: 222136:BBW65_RS02075
uniprot id: A0A1B1U4P2
names: Caution
names: Function
names: Similarity
messages: Belongs to the dUTPase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

222136:BBW65 RS00650
gene id: 222136:BBW65_RS00650
uniprot id: A0A1B1U3T9
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

222136:BBW65 RS03905
gene id: 222136:BBW65_RS03905
uniprot id: A0A1B1U5M6
names: Function
names: Similarity
messages: Belongs to the OMP decarboxylase family.
messages: Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).

222136:BBW65 RS03745
gene id: 222136:BBW65_RS03745
uniprot id: A0A1B1U5J7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.
messages: Secreted

222136:BBW65 RS02780
gene id: 222136:BBW65_RS02780
uniprot id: A0A1B1U506
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

222136:BBW65 RS05975
gene id: 222136:BBW65_RS05975
uniprot id: A0A1B1U6P7
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

222136:BBW65 RS02255
gene id: 222136:BBW65_RS02255
uniprot id: A0A1B1U4M1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NapD family.
messages: Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin-arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.
messages: Cytoplasm
messages: Interacts with the cytoplasmic NapA precursor.

222136:BBW65 RS00950
gene id: 222136:BBW65_RS00950
uniprot id: A0A1B1U3Y8
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL9 family.
messages: Binds to the 23S rRNA.

222136:BBW65 RS03350
gene id: 222136:BBW65_RS03350
uniprot id: A0A1B1U548
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

222136:BBW65 RS03025
gene id: 222136:BBW65_RS03025
uniprot id: A0A1B1U4X1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.
messages: Cell membrane
messages: Involved in the import of queuosine (Q) precursors, required for Q precursor salvage.

222136:BBW65 RS06290
gene id: 222136:BBW65_RS06290
uniprot id: A0A1B1U6P0
names: Similarity
messages: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.

222136:BBW65 RS03590
gene id: 222136:BBW65_RS03590
uniprot id: A0A1B1U5A2
names: Similarity
messages: In the C-terminal section; belongs to the complex I 49 kDa subunit family.

222136:BBW65 RS04185
gene id: 222136:BBW65_RS04185
uniprot id: A0A1B1U5L4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.
messages: Cell inner membrane
messages: Membrane

222136:BBW65 RS02840
gene id: 222136:BBW65_RS02840
uniprot id: A0A1B1U4S9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Cell inner membrane
messages: Membrane

222136:BBW65 RS02190
gene id: 222136:BBW65_RS02190
uniprot id: A0A1B1U7T3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.

222136:BBW65 RS06360
gene id: 222136:BBW65_RS06360
uniprot id: A0A1B1U6R6
names: Similarity
messages: Belongs to the UDPGP type 2 family.

222136:BBW65 RS05305
gene id: 222136:BBW65_RS05305
uniprot id: A0A1B1U628
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the RNase HII family.
messages: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
messages: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

222136:BBW65 RS03195
gene id: 222136:BBW65_RS03195
uniprot id: A0A1B1U536
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the BPG-independent phosphoglycerate mutase family.
messages: Binds 2 manganese ions per subunit.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
messages: Monomer.

222136:BBW65 RS07495
gene id: 222136:BBW65_RS07495
uniprot id: A0A1B1U7E8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm

222136:BBW65 RS00345
gene id: 222136:BBW65_RS00345
uniprot id: A0A1B1U3M2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliF family.
messages: Membrane
messages: The M ring may be actively involved in energy transduction.

222136:BBW65 RS07175
gene id: 222136:BBW65_RS07175
uniprot id: A0A1B1U744
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccA family.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

222136:BBW65 RS04595
gene id: 222136:BBW65_RS04595
uniprot id: A0A1B1U5Z7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RbfA family.
messages: Cytoplasm
messages: Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.
messages: One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.

222136:BBW65 RS01255
gene id: 222136:BBW65_RS01255
uniprot id: A0A1B1U438
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
messages: Catalyzes the sodium-dependent uptake of extracellular L-proline.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

222136:BBW65 RS02390
gene id: 222136:BBW65_RS02390
uniprot id: A0A1B1U4M7
names: Similarity
names: Subunit
messages: Belongs to the ALAD family.
messages: Homooctamer.

222136:BBW65 RS08110
gene id: 222136:BBW65_RS08110
uniprot id: A0A1B1U612
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

222136:BBW65 RS05945
gene id: 222136:BBW65_RS05945
uniprot id: A0A1B1U6K1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family.
messages: Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
messages: Cytoplasm

222136:BBW65 RS00225
gene id: 222136:BBW65_RS00225
uniprot id: A0A1B1U3K7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MotA family.
messages: Cell inner membrane
messages: Membrane

222136:BBW65 RS07390
gene id: 222136:BBW65_RS07390
uniprot id: A0A1B1U7B2
names: Similarity
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.

222136:BBW65 RS05880
gene id: 222136:BBW65_RS05880
uniprot id: A0A1B1U6D1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribonuclease III family.
messages: Cytoplasm
messages: Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
messages: Homodimer.

222136:BBW65 RS04590
gene id: 222136:BBW65_RS04590
uniprot id: A0A1B1U5W9
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes.
messages: Belongs to the Fur family.
messages: Binds 1 zinc ion per subunit.
messages: Homodimer.

222136:BBW65 RS07370
gene id: 222136:BBW65_RS07370
uniprot id: A0A1B1U7A7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

222136:BBW65 RS03110
gene id: 222136:BBW65_RS03110
uniprot id: A0A1B1U574
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase subunit omega family.
messages: Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
messages: The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

222136:BBW65 RS01570
gene id: 222136:BBW65_RS01570
uniprot id: A0A1B1U491
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the dethiobiotin synthetase family.
messages: Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS06240
gene id: 222136:BBW65_RS06240
uniprot id: A0A1B1U6M9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
messages: Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
messages: Cytoplasm

222136:BBW65 RS07600
gene id: 222136:BBW65_RS07600
uniprot id: A0A1B1U7C0
names: Similarity
messages: Belongs to the catalase family.

222136:BBW65 RS06465
gene id: 222136:BBW65_RS06465
uniprot id: A0A1B1U6T5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ExbD/TolR family.
messages: Cell inner membrane
messages: Cell membrane
messages: Membrane

222136:BBW65 RS02750
gene id: 222136:BBW65_RS02750
uniprot id: A0A1B1U4V4
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ArgJ family.
messages: Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.
messages: Cytoplasm
messages: Heterotetramer of two alpha and two beta chains.
messages: Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

222136:BBW65 RS01185
gene id: 222136:BBW65_RS01185
uniprot id: A0A1B1U430
names: Similarity
messages: Belongs to the peptidase M24B family.

222136:BBW65 RS05510
gene id: 222136:BBW65_RS05510
uniprot id: A0A1B1U662
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

222136:BBW65 RS01755
gene id: 222136:BBW65_RS01755
uniprot id: A0A1B1U4C8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylosuccinate synthetase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

222136:BBW65 RS03075
gene id: 222136:BBW65_RS03075
uniprot id: A0A1B1U514
names: Similarity
messages: Belongs to the sigma-54 factor family.

222136:BBW65 RS04685
gene id: 222136:BBW65_RS04685
uniprot id: A0A1B1U5W2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the peptidase S14 family.
messages: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
messages: Cytoplasm
messages: Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

222136:BBW65 RS06265
gene id: 222136:BBW65_RS06265
uniprot id: A0A1B1U6K6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
messages: Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.
messages: Cytoplasm
messages: Homodimer.

222136:BBW65 RS04130
gene id: 222136:BBW65_RS04130
uniprot id: A0A1B1U5K4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

222136:BBW65 RS01935
gene id: 222136:BBW65_RS01935
uniprot id: A0A1B1U4H8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Membrane
messages: Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.

222136:BBW65 RS07530
gene id: 222136:BBW65_RS07530
uniprot id: A0A1B1U775
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.
messages: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS02275
gene id: 222136:BBW65_RS02275
uniprot id: A0A1B1U4R8
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.

222136:BBW65 RS04900
gene id: 222136:BBW65_RS04900
uniprot id: A0A1B1U600
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
messages: Belongs to the type II topoisomerase GyrB family.
messages: Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).
messages: Cytoplasm
messages: Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.
messages: Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.

222136:BBW65 RS03235
gene id: 222136:BBW65_RS03235
uniprot id: A0A1B1U540
names: Subcellular Location Annotation
messages: Membrane

222136:BBW65 RS01945
gene id: 222136:BBW65_RS01945
uniprot id: A0A1B1U4F7
names: Similarity
messages: Belongs to the bacterial solute-binding protein ModA family.

222136:BBW65 RS06295
gene id: 222136:BBW65_RS06295
uniprot id: A0A1B1U6P4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliR/MopE/SpaR family.
messages: Cell membrane
messages: Membrane
messages: Role in flagellar biosynthesis.

222136:BBW65 RS06120
gene id: 222136:BBW65_RS06120
uniprot id: A0A1B1U6N0
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the uroporphyrinogen decarboxylase family.
messages: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS02375
gene id: 222136:BBW65_RS02375
uniprot id: A0A1B1U4P0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RNA methyltransferase RsmE family.
messages: Cytoplasm
messages: Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.

222136:BBW65 RS03100
gene id: 222136:BBW65_RS03100
uniprot id: A0A1B1U543
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
messages: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

222136:BBW65 RS03850
gene id: 222136:BBW65_RS03850
uniprot id: A0A1B1U5B0
names: Function
names: Similarity
messages: Belongs to the RecN family.
messages: May be involved in recombinational repair of damaged DNA.

222136:BBW65 RS05290
gene id: 222136:BBW65_RS05290
uniprot id: A0A1B1U7R6
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliP/MopC/SpaP family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Plays a role in the flagellum-specific transport system.

222136:BBW65 RS00400
gene id: 222136:BBW65_RS00400
uniprot id: A0A1B1U3N9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FdhD family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.

222136:BBW65 RS05460
gene id: 222136:BBW65_RS05460
uniprot id: A0A1B1U695
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GSP F family.
messages: Membrane

222136:BBW65 RS05520
gene id: 222136:BBW65_RS05520
uniprot id: A0A1B1U6A0
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

222136:BBW65 RS04515
gene id: 222136:BBW65_RS04515
uniprot id: A0A1B1U5S9
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the heme-copper respiratory oxidase family.
messages: Binds 1 copper ion per subunit, denoted as copper B.
messages: Binds 2 heme groups per subunit, denoted as high- and low-spin.
messages: Membrane

222136:BBW65 RS06780
gene id: 222136:BBW65_RS06780
uniprot id: A0A1B1U752
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsX family.
messages: Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
messages: Cytoplasm
messages: Homodimer. Probably interacts with PlsY.

222136:BBW65 RS05395
gene id: 222136:BBW65_RS05395
uniprot id: A0A1B1U6F1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL6 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.

222136:BBW65 RS07435
gene id: 222136:BBW65_RS07435
uniprot id: A0A1B1U790
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

222136:BBW65 RS01350
gene id: 222136:BBW65_RS01350
uniprot id: A0A1B1U4A5
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M3 family.
messages: Binds 1 zinc ion.

222136:BBW65 RS05155
gene id: 222136:BBW65_RS05155
uniprot id: A0A1B1U603
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
messages: Cell inner membrane
messages: Membrane
messages: Probable transporter of a GTP-driven Fe(2+) uptake system.

222136:BBW65 RS06760
gene id: 222136:BBW65_RS06760
uniprot id: A0A1B1U709
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).

222136:BBW65 RS04400
gene id: 222136:BBW65_RS04400
uniprot id: A0A1B1U5Q2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.
messages: Binds the 23S rRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of the 50S ribosomal subunit.

222136:BBW65 RS03090
gene id: 222136:BBW65_RS03090
uniprot id: A0A1B1U515
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaX/STICHEL family.
messages: DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.
messages: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

222136:BBW65 RS06040
gene id: 222136:BBW65_RS06040
uniprot id: A0A1B1U6Q7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
messages: Bacterial flagellum basal body
messages: Belongs to the FlgI family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.

222136:BBW65 RS04025
gene id: 222136:BBW65_RS04025
uniprot id: A0A1B1U5J0
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

222136:BBW65 RS00700
gene id: 222136:BBW65_RS00700
uniprot id: A0A1B1U405
names: Caution
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the CarB family.
messages: Binds 4 Mg(2+) or Mn(2+) ions per subunit.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS00395
gene id: 222136:BBW65_RS00395
uniprot id: A0A1B1U3R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the PEP-utilizing enzyme family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).

222136:BBW65 RS03120
gene id: 222136:BBW65_RS03120
uniprot id: A0A1B1U4X6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.
messages: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
messages: Cytoplasm
messages: Homodimer.

222136:BBW65 RS04810
gene id: 222136:BBW65_RS04810
uniprot id: A0A1B1U609
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

222136:BBW65 RS04575
gene id: 222136:BBW65_RS04575
uniprot id: A0A1B1U5T8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 28 family. MurG subfamily.
messages: Cell membrane
messages: Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS03670
gene id: 222136:BBW65_RS03670
uniprot id: A0A1B1U5E4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Specifically methylates the N7 position of a guanine in 16S rRNA.

222136:BBW65 RS00915
gene id: 222136:BBW65_RS00915
uniprot id: A0A1B1U408
names: Subcellular Location Annotation
messages: Membrane

222136:BBW65 RS02000
gene id: 222136:BBW65_RS02000
uniprot id: A0A1B1U7L8
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.
messages: Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS04770
gene id: 222136:BBW65_RS04770
uniprot id: A0A1B1U5S7
names: Caution
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the radical SAM superfamily. RlmN family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.
messages: Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.

222136:BBW65 RS06860
gene id: 222136:BBW65_RS06860
uniprot id: A0A1B1U729
names: Similarity
messages: Belongs to the Nudix hydrolase family.

222136:BBW65 RS03200
gene id: 222136:BBW65_RS03200
uniprot id: A0A1B1U535
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the formate dehydrogenase gamma subunit family.
messages: Membrane

222136:BBW65 RS06100
gene id: 222136:BBW65_RS06100
uniprot id: A0A1B1U6S1
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the aspartate-semialdehyde dehydrogenase family.
messages: Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS01965
gene id: 222136:BBW65_RS01965
uniprot id: A0A1B1U7I6
names: Caution
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.
messages: Binds 1 [4Fe-4S] cluster.
messages: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.
messages: Catalytic subunit of the nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
messages: Component of the nitrate reductase NapAB complex composed of NapA and NapB.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Predicted to be exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven.
messages: Secreted

222136:BBW65 RS05055
gene id: 222136:BBW65_RS05055
uniprot id: A0A1B1U694
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

222136:BBW65 RS06440
gene id: 222136:BBW65_RS06440
uniprot id: A0A1B1U6Z0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

222136:BBW65 RS05420
gene id: 222136:BBW65_RS05420
uniprot id: A0A1B1U699
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

222136:BBW65 RS05300
gene id: 222136:BBW65_RS05300
uniprot id: A0A1B1U669
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.

222136:BBW65 RS02665
gene id: 222136:BBW65_RS02665
uniprot id: A0A1B1U4T7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YajC family.
messages: Membrane

222136:BBW65 RS04895
gene id: 222136:BBW65_RS04895
uniprot id: A0A1B1U5W1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the beta sliding clamp family.
messages: Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.
messages: Cytoplasm
messages: Forms a ring-shaped head-to-tail homodimer around DNA.

222136:BBW65 RS04540
gene id: 222136:BBW65_RS04540
uniprot id: A0A1B1U5R3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the triosephosphate isomerase family.
messages: Cytoplasm
messages: Homodimer.

222136:BBW65 RS01390
gene id: 222136:BBW65_RS01390
uniprot id: A0A1B1U457
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.

222136:BBW65 RS00205
gene id: 222136:BBW65_RS00205
uniprot id: A0A1B1U3J4
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

222136:BBW65 RS02295
gene id: 222136:BBW65_RS02295
uniprot id: A0A1B1U4T5
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF1.
messages: Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.

222136:BBW65 RS07590
gene id: 222136:BBW65_RS07590
uniprot id: A0A1B1U787
names: Similarity
messages: Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

222136:BBW65 RS06335
gene id: 222136:BBW65_RS06335
uniprot id: A0A1B1U6S4
names: Subcellular Location Annotation
messages: Membrane

222136:BBW65 RS00115
gene id: 222136:BBW65_RS00115
uniprot id: A0A1B1U7E6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Cell inner membrane
messages: Homopentamer. In the absence of Mg(2+), interactions between subunits are weakened, and dimers, trimers and tetramers can be observed in vitro.
messages: Mediates influx of magnesium ions.
messages: Membrane

222136:BBW65 RS04205
gene id: 222136:BBW65_RS04205
uniprot id: A0A1B1U5S8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.
messages: Cytoplasm
messages: Monomer.

222136:BBW65 RS06405
gene id: 222136:BBW65_RS06405
uniprot id: A0A1B1U7M4
names: Function
names: Similarity
messages: Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
messages: Belongs to the Fmt family.

222136:BBW65 RS06430
gene id: 222136:BBW65_RS06430
uniprot id: A0A1B1U6N3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase B chain family.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Membrane

222136:BBW65 RS05435
gene id: 222136:BBW65_RS05435
uniprot id: A0A1B1U663
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

222136:BBW65 RS04300
gene id: 222136:BBW65_RS04300
uniprot id: A0A1B1U5R5
names: Function
names: Similarity
messages: Belongs to the NusG family.
messages: Participates in transcription elongation, termination and antitermination.

222136:BBW65 RS01315
gene id: 222136:BBW65_RS01315
uniprot id: A0A1B1U448
names: Similarity
names: Subunit
messages: Belongs to the GTP cyclohydrolase I family.
messages: Homopolymer.

222136:BBW65 RS01715
gene id: 222136:BBW65_RS01715
uniprot id: A0A1B1U4D5
names: Similarity
messages: Belongs to the flagella basal body rod proteins family.

222136:BBW65 RS02740
gene id: 222136:BBW65_RS02740
uniprot id: A0A1B1U4Q9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

222136:BBW65 RS05500
gene id: 222136:BBW65_RS05500
uniprot id: A0A1B1U6H3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).
messages: Belongs to the AccD/PCCB family.
messages: Binds 1 zinc ion per subunit.
messages: Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
messages: Cytoplasm

222136:BBW65 RS01800
gene id: 222136:BBW65_RS01800
uniprot id: A0A1B1U4J3
names: Similarity
names: Subcellular Location Annotation
messages: Bacterial flagellum basal body
messages: Belongs to the FliM family.
messages: Membrane

222136:BBW65 RS05320
gene id: 222136:BBW65_RS05320
uniprot id: A0A1B1U676
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

222136:BBW65 RS03415
gene id: 222136:BBW65_RS03415
uniprot id: A0A1B1U530
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the heat shock protein 90 family.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Molecular chaperone. Has ATPase activity.

222136:BBW65 RS01325
gene id: 222136:BBW65_RS01325
uniprot id: A0A1B1U442
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

222136:BBW65 RS06420
gene id: 222136:BBW65_RS06420
uniprot id: A0A1B1U6V5
names: Similarity
messages: Belongs to the ParB family.

222136:BBW65 RS02645
gene id: 222136:BBW65_RS02645
uniprot id: A0A1B1U4T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm

222136:BBW65 RS03600
gene id: 222136:BBW65_RS03600
uniprot id: A0A1B1U5A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 3 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.

222136:BBW65 RS03710
gene id: 222136:BBW65_RS03710
uniprot id: A0A1B1U7V0
names: Similarity
messages: Belongs to the peptidase M16 family.

222136:BBW65 RS03910
gene id: 222136:BBW65_RS03910
uniprot id: A0A1B1U5G2
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the pantothenate synthetase family.
messages: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
messages: Cytoplasm
messages: Homodimer.
messages: The reaction proceeds by a bi uni uni bi ping pong mechanism.

222136:BBW65 RS01260
gene id: 222136:BBW65_RS01260
uniprot id: A0A1B1U440
names: Similarity
messages: Belongs to the aldehyde dehydrogenase family.

222136:BBW65 RS01320
gene id: 222136:BBW65_RS01320
uniprot id: A0A1B1U449
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruD family.
messages: Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.

222136:BBW65 RS03555
gene id: 222136:BBW65_RS03555
uniprot id: A0A1B1U599
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 4L family.
messages: Cell membrane
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

222136:BBW65 RS01125
gene id: 222136:BBW65_RS01125
uniprot id: A0A1B1U418
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

222136:BBW65 RS00745
gene id: 222136:BBW65_RS00745
uniprot id: A0A1B1U7F4
names: Similarity
messages: Belongs to the peptidase S41A family.

222136:BBW65 RS01870
gene id: 222136:BBW65_RS01870
uniprot id: A0A1B1U4F0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

222136:BBW65 RS05315
gene id: 222136:BBW65_RS05315
uniprot id: A0A1B1U664
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

222136:BBW65 RS02040
gene id: 222136:BBW65_RS02040
uniprot id: A0A1B1U4H9
names: Function
names: Similarity
names: Subunit
messages: Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
messages: Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.
messages: Homodimer.
messages: In the C-terminal section; belongs to the cytidylyltransferase family.
messages: In the N-terminal section; belongs to the carbohydrate kinase PfkB family.

222136:BBW65 RS07140
gene id: 222136:BBW65_RS07140
uniprot id: A0A1B1U7B7
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family.

222136:BBW65 RS06275
gene id: 222136:BBW65_RS06275
uniprot id: A0A1B1U6W3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsA/MreB family.
messages: Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
messages: Cell membrane
messages: Self-interacts. Interacts with FtsZ.

222136:BBW65 RS03815
gene id: 222136:BBW65_RS03815
uniprot id: A0A1B1U5A5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.
messages: Cytoplasm
messages: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.

222136:BBW65 RS00100
gene id: 222136:BBW65_RS00100
uniprot id: A0A1B1U7E3
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

222136:BBW65 RS07535
gene id: 222136:BBW65_RS07535
uniprot id: A0A1B1U7A8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

222136:BBW65 RS04610
gene id: 222136:BBW65_RS04610
uniprot id: A0A1B1U608
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

222136:BBW65 RS02450
gene id: 222136:BBW65_RS02450
uniprot id: A0A1B1U4L0
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

222136:BBW65 RS06220
gene id: 222136:BBW65_RS06220
uniprot id: A0A1B1U6I9
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatB/GatE family. GatB subfamily.
messages: Heterotrimer of A, B and C subunits.

222136:BBW65 RS04850
gene id: 222136:BBW65_RS04850
uniprot id: A0A1B1U5Z0
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
messages: Cytoplasm
messages: IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).
messages: Monomer.

222136:BBW65 RS02875
gene id: 222136:BBW65_RS02875
uniprot id: A0A1B1U4Y0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliL family.
messages: Cell membrane
messages: Controls the rotational direction of flagella during chemotaxis.
messages: Membrane

222136:BBW65 RS05990
gene id: 222136:BBW65_RS05990
uniprot id: A0A1B1U6Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SelA family.
messages: Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
messages: Cytoplasm

222136:BBW65 RS07540
gene id: 222136:BBW65_RS07540
uniprot id: A0A1B1U7N1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SecG family.
messages: Cell membrane
messages: Involved in protein export. Participates in an early event of protein translocation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

222136:BBW65 RS05260
gene id: 222136:BBW65_RS05260
uniprot id: A0A1B1U656
names: Domain
names: Function
names: Similarity
messages: Belongs to the RecA family. RadA subfamily.
messages: DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
messages: Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.
messages: The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.

222136:BBW65 RS02500
gene id: 222136:BBW65_RS02500
uniprot id: A0A1B1U4P7
names: Function
names: Similarity
messages: Belongs to the LpxK family.
messages: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).

222136:BBW65 RS00815
gene id: 222136:BBW65_RS00815
uniprot id: A0A1B1U3V7
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase M17 family.
messages: Binds 2 manganese ions per subunit.
messages: Cytoplasm
messages: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

222136:BBW65 RS03040
gene id: 222136:BBW65_RS03040
uniprot id: A0A1B1U509
names: Similarity
messages: Belongs to the RecJ family.

222136:BBW65 RS04315
gene id: 222136:BBW65_RS04315
uniprot id: A0A1B1U5M2
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

222136:BBW65 RS00250
gene id: 222136:BBW65_RS00250
uniprot id: A0A1B1U3S5
names: Similarity
messages: Belongs to the helicase family. UvrD subfamily.

222136:BBW65 RS04565
gene id: 222136:BBW65_RS04565
uniprot id: A0A1B1U5T2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

222136:BBW65 RS02235
gene id: 222136:BBW65_RS02235
uniprot id: A0A1B1U4H0
names: Similarity
messages: Belongs to the universal ribosomal protein uS2 family.

222136:BBW65 RS02110
gene id: 222136:BBW65_RS02110
uniprot id: A0A1B1U4N8
names: Similarity
messages: Belongs to the phosphohexose mutase family.

222136:BBW65 RS06390
gene id: 222136:BBW65_RS06390
uniprot id: A0A1B1U6T3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL21 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L20.
messages: This protein binds to 23S rRNA in the presence of protein L20.

222136:BBW65 RS04465
gene id: 222136:BBW65_RS04465
uniprot id: A0A1B1U5R4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.
messages: Cell membrane
messages: Membrane

222136:BBW65 RS04840
gene id: 222136:BBW65_RS04840
uniprot id: A0A1B1U5Y3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MlaE permease family.
messages: Membrane

222136:BBW65 RS03730
gene id: 222136:BBW65_RS03730
uniprot id: A0A1B1U5I9
names: Similarity
messages: Belongs to the UbiD family.

222136:BBW65 RS01745
gene id: 222136:BBW65_RS01745
uniprot id: A0A1B1U4I4
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnC family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).

222136:BBW65 RS01950
gene id: 222136:BBW65_RS01950
uniprot id: A0A1B1U4C2
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NapB family.
messages: Binds 2 heme C groups per subunit.
messages: Periplasm

222136:BBW65 RS04955
gene id: 222136:BBW65_RS04955
uniprot id: A0A1B1U671
names: Subcellular Location Annotation
messages: Cell outer membrane
messages: Membrane

222136:BBW65 RS00300
gene id: 222136:BBW65_RS00300
uniprot id: A0A1B1U3K0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurCDEF family. MurE subfamily.
messages: Cytoplasm

222136:BBW65 RS00820
gene id: 222136:BBW65_RS00820
uniprot id: A0A1B1U3T2
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

222136:BBW65 RS02940
gene id: 222136:BBW65_RS02940
uniprot id: A0A1B1U4X5
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

222136:BBW65 RS01385
gene id: 222136:BBW65_RS01385
uniprot id: A0A1B1U496
names: Function
names: Subunit
messages: Catalyzes the synthesis of GMP from XMP.
messages: Homodimer.

222136:BBW65 RS06500
gene id: 222136:BBW65_RS06500
uniprot id: A0A1B1U6P5
names: Similarity
messages: Belongs to the peptidase S49 family.

222136:BBW65 RS01110
gene id: 222136:BBW65_RS01110
uniprot id: A0A1B1U416
names: Similarity
names: Subunit
messages: Belongs to the KdsC family.
messages: Homotetramer.

222136:BBW65 RS06400
gene id: 222136:BBW65_RS06400
uniprot id: A0A1B1U6R2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
messages: Cytoplasm
messages: Monomer.

222136:BBW65 RS04355
gene id: 222136:BBW65_RS04355
uniprot id: A0A1B1U5K5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapB family.
messages: Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.

222136:BBW65 RS06560
gene id: 222136:BBW65_RS06560
uniprot id: A0A1B1U6T8
names: Similarity
messages: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.

222136:BBW65 RS04075
gene id: 222136:BBW65_RS04075
uniprot id: A0A1B1U5J8
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

222136:BBW65 RS03855
gene id: 222136:BBW65_RS03855
uniprot id: A0A1B1U5L8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD kinase family.
messages: Cytoplasm
messages: Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS01835
gene id: 222136:BBW65_RS01835
uniprot id: A0A1B1U4F8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Catalyzes the attachment of tryptophan to tRNA(Trp).
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS06450
gene id: 222136:BBW65_RS06450
uniprot id: A0A1B1U6N6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

222136:BBW65 RS04960
gene id: 222136:BBW65_RS04960
uniprot id: A0A1B1U602
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferritin family. Prokaryotic subfamily.
messages: Cytoplasm
messages: Iron-storage protein.

222136:BBW65 RS01270
gene id: 222136:BBW65_RS01270
uniprot id: A0A1B1U456
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the MnmG family.
messages: Cytoplasm
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.

222136:BBW65 RS01040
gene id: 222136:BBW65_RS01040
uniprot id: A0A1B1U3X0
names: Subunit
messages: Homodimer.

222136:BBW65 RS03900
gene id: 222136:BBW65_RS03900
uniprot id: A0A1B1U5B8
names: Function
names: Similarity
messages: Belongs to the NusB family.
messages: Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

222136:BBW65 RS00730
gene id: 222136:BBW65_RS00730
uniprot id: A0A1B1U3U6
names: Similarity
messages: Belongs to the ClpA/ClpB family.

222136:BBW65 RS04905
gene id: 222136:BBW65_RS04905
uniprot id: A0A1B1U5Z4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PlsY family.
messages: Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
messages: Cell membrane
messages: Probably interacts with PlsX.

222136:BBW65 RS04750
gene id: 222136:BBW65_RS04750
uniprot id: A0A1B1U5X1
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

222136:BBW65 RS01145
gene id: 222136:BBW65_RS01145
uniprot id: A0A1B1U450
names: Similarity
messages: Belongs to the polysaccharide synthase family.

222136:BBW65 RS04320
gene id: 222136:BBW65_RS04320
uniprot id: A0A1B1U5K1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.
messages: Cytoplasm
messages: Monomer.
messages: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

222136:BBW65 RS04460
gene id: 222136:BBW65_RS04460
uniprot id: A0A1B1U5R9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

222136:BBW65 RS05095
gene id: 222136:BBW65_RS05095
uniprot id: A0A1B1U605
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the DnaG primase family.
messages: Binds 1 zinc ion per monomer.
messages: Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.
messages: Monomer. Interacts with DnaB.
messages: RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.

222136:BBW65 RS00245
gene id: 222136:BBW65_RS00245
uniprot id: A0A1B1U3J1
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

222136:BBW65 RS01885
gene id: 222136:BBW65_RS01885
uniprot id: A0A1B1U4G9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

222136:BBW65 RS06810
gene id: 222136:BBW65_RS06810
uniprot id: A0A1B1U720
names: Similarity
messages: Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

222136:BBW65 RS06510
gene id: 222136:BBW65_RS06510
uniprot id: A0A1B1U6S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MscS (TC 1.A.23) family.
messages: Membrane

222136:BBW65 RS04600
gene id: 222136:BBW65_RS04600
uniprot id: A0A1B1U5S1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

222136:BBW65 RS07655
gene id: 222136:BBW65_RS07655
uniprot id: A0A1B1U7C4
names: Function
names: Similarity
messages: Belongs to the NadC/ModD family.
messages: Involved in the catabolism of quinolinic acid (QA).

222136:BBW65 RS06425
gene id: 222136:BBW65_RS06425
uniprot id: A0A1B1U6Y6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase B chain family.
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Membrane

222136:BBW65 RS01180
gene id: 222136:BBW65_RS01180
uniprot id: A0A1B1U428
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.
messages: Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.

222136:BBW65 RS03180
gene id: 222136:BBW65_RS03180
uniprot id: A0A1B1U5A1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PNP synthase family.
messages: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
messages: Cytoplasm
messages: Homooctamer; tetramer of dimers.

222136:BBW65 RS00500
gene id: 222136:BBW65_RS00500
uniprot id: A0A1B1U3Q3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the polyribonucleotide nucleotidyltransferase family.
messages: Cytoplasm
messages: Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

222136:BBW65 RS04135
gene id: 222136:BBW65_RS04135
uniprot id: A0A1B1U5L3
names: Function
names: Similarity
messages: Belongs to the AIR carboxylase family. Class I subfamily.
messages: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).

222136:BBW65 RS04815
gene id: 222136:BBW65_RS04815
uniprot id: A0A1B1U632
names: Similarity
messages: Belongs to the SIS family. GutQ/KpsF subfamily.

222136:BBW65 RS05380
gene id: 222136:BBW65_RS05380
uniprot id: A0A1B1U6D6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

222136:BBW65 RS03780
gene id: 222136:BBW65_RS03780
uniprot id: A0A1B1U5G3
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the argininosuccinate synthase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homotetramer.

222136:BBW65 RS04070
gene id: 222136:BBW65_RS04070
uniprot id: A0A1B1U5F8
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

222136:BBW65 RS02330
gene id: 222136:BBW65_RS02330
uniprot id: A0A1B1U4T0
names: Subcellular Location Annotation
messages: Membrane

222136:BBW65 RS00945
gene id: 222136:BBW65_RS00945
uniprot id: A0A1B1U3W5
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.
messages: Allosterically activated by HslU binding.
messages: Belongs to the peptidase T1B family. HslV subfamily.
messages: Cytoplasm
messages: Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.

222136:BBW65 RS01890
gene id: 222136:BBW65_RS01890
uniprot id: A0A1B1U4I9
names: Similarity
messages: Belongs to the GHMP kinase family. IspE subfamily.

222136:BBW65 RS03790
gene id: 222136:BBW65_RS03790
uniprot id: A0A1B1U5K0
names: Function
names: Similarity
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.
messages: Catalyzes the biosynthesis of agmatine from arginine.

222136:BBW65 RS03580
gene id: 222136:BBW65_RS03580
uniprot id: A0A1B1U559
names: Similarity
messages: Belongs to the complex I 51 kDa subunit family.

222136:BBW65 RS04710
gene id: 222136:BBW65_RS04710
uniprot id: A0A1B1U5T9
names: Similarity
messages: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.

222136:BBW65 RS02250
gene id: 222136:BBW65_RS02250
uniprot id: A0A1B1U4I3
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Catalyzes the ATP-dependent phosphorylation of sn-l,2-diacylglycerol (DAG) to phosphatidic acid. Involved in the recycling of diacylglycerol produced as a by-product during membrane-derived oligosaccharide (MDO) biosynthesis.
messages: Cell inner membrane
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

222136:BBW65 RS01150
gene id: 222136:BBW65_RS01150
uniprot id: A0A1B1U417
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 FMN per subunit.
messages: Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.
messages: In the C-terminal section; belongs to the PPC synthetase family.
messages: In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS01780
gene id: 222136:BBW65_RS01780
uniprot id: A0A1B1U4E3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GTP-binding SRP family.
messages: Cell membrane
messages: Membrane
messages: Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.

222136:BBW65 RS02820
gene id: 222136:BBW65_RS02820
uniprot id: A0A1B1U4X3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

222136:BBW65 RS07440
gene id: 222136:BBW65_RS07440
uniprot id: A0A1B1U7C1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PPase family.
messages: Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
messages: Cytoplasm
messages: Homohexamer.

222136:BBW65 RS06260
gene id: 222136:BBW65_RS06260
uniprot id: A0A1B1U6V1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ferrochelatase family.
messages: Catalyzes the ferrous insertion into protoporphyrin IX.
messages: Cytoplasm

222136:BBW65 RS05400
gene id: 222136:BBW65_RS05400
uniprot id: A0A1B1U697
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL18 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.
messages: This is one of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.

222136:BBW65 RS01210
gene id: 222136:BBW65_RS01210
uniprot id: A0A1B1U459
names: Caution
names: Function
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.
messages: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS06935
gene id: 222136:BBW65_RS06935
uniprot id: A0A1B1U6X3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the dCTP deaminase family.
messages: Catalyzes the deamination of dCTP to dUTP.
messages: Homotrimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS04890
gene id: 222136:BBW65_RS04890
uniprot id: A0A1B1U5Z3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

222136:BBW65 RS06315
gene id: 222136:BBW65_RS06315
uniprot id: A0A1B1U6L4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatA/E family.
messages: Cell membrane
messages: Forms a complex with TatC.
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.

222136:BBW65 RS00975
gene id: 222136:BBW65_RS00975
uniprot id: A0A1B1U419
names: Similarity
messages: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.

222136:BBW65 RS04245
gene id: 222136:BBW65_RS04245
uniprot id: A0A1B1U5N3
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the prokaryotic/mitochondrial release factor family.
messages: Cytoplasm
messages: Methylated by PrmC. Methylation increases the termination efficiency of RF2.
messages: Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.

222136:BBW65 RS00665
gene id: 222136:BBW65_RS00665
uniprot id: A0A1B1U3T5
names: Similarity
messages: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.

222136:BBW65 RS06460
gene id: 222136:BBW65_RS06460
uniprot id: A0A1B1U6S3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Cell inner membrane
messages: Membrane

222136:BBW65 RS03115
gene id: 222136:BBW65_RS03115
uniprot id: A0A1B1U513
names: Function
names: Similarity
messages: Belongs to the relA/spoT family.
messages: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.

222136:BBW65 RS01805
gene id: 222136:BBW65_RS01805
uniprot id: A0A1B1U4D9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

222136:BBW65 RS06320
gene id: 222136:BBW65_RS06320
uniprot id: A0A1B1U6L0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Monomer.

222136:BBW65 RS03035
gene id: 222136:BBW65_RS03035
uniprot id: A0A1B1U505
names: Activity Regulation
names: Caution
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.
messages: Belongs to the CTP synthase family.
messages: CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.
messages: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS00710
gene id: 222136:BBW65_RS00710
uniprot id: A0A1B1U3U8
names: Subcellular Location Annotation
messages: Membrane

222136:BBW65 RS02975
gene id: 222136:BBW65_RS02975
uniprot id: A0A1B1U4Z7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane

222136:BBW65 RS07575
gene id: 222136:BBW65_RS07575
uniprot id: A0A1B1U7L4
names: Function
names: Similarity
messages: Belongs to the Thz kinase family.
messages: Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).

222136:BBW65 RS00240
gene id: 222136:BBW65_RS00240
uniprot id: A0A1B1U3J9
names: Similarity
messages: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

222136:BBW65 RS03095
gene id: 222136:BBW65_RS03095
uniprot id: A0A1B1U520
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0126 family.
messages: Membrane

222136:BBW65 RS03175
gene id: 222136:BBW65_RS03175
uniprot id: A0A1B1U4Y6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transferase hexapeptide repeat family. LpxD subfamily.
messages: Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
messages: Homotrimer.

222136:BBW65 RS02270
gene id: 222136:BBW65_RS02270
uniprot id: A0A1B1U4N4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-3 family.
messages: Cytoplasm
messages: IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
messages: Monomer.

222136:BBW65 RS04635
gene id: 222136:BBW65_RS04635
uniprot id: A0A1B1U5U4
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MobA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.
messages: Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.

222136:BBW65 RS03895
gene id: 222136:BBW65_RS03895
uniprot id: A0A1B1U5E6
names: Function
names: Similarity
messages: Belongs to the DMRL synthase family.
messages: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.

222136:BBW65 RS03570
gene id: 222136:BBW65_RS03570
uniprot id: A0A1B1U5F9
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I subunit 1 family.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.

222136:BBW65 RS02945
gene id: 222136:BBW65_RS02945
uniprot id: A0A1B1U4U9
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase TrmD family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates guanosine-37 in various tRNAs.

222136:BBW65 RS04535
gene id: 222136:BBW65_RS04535
uniprot id: A0A1B1U5Y9
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.

222136:BBW65 RS07515
gene id: 222136:BBW65_RS07515
uniprot id: A0A1B1U783
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the shikimate kinase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

222136:BBW65 RS04630
gene id: 222136:BBW65_RS04630
uniprot id: A0A1B1U5V0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the type III secretion exporter family.
messages: Cell membrane
messages: Membrane
messages: Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.

222136:BBW65 RS01760
gene id: 222136:BBW65_RS01760
uniprot id: A0A1B1U4A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliJ family.
messages: Cell membrane
messages: Membrane

222136:BBW65 RS03740
gene id: 222136:BBW65_RS03740
uniprot id: A0A1B1U590
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Iojap/RsfS family.
messages: Cytoplasm
messages: Functions as a ribosomal silencing factor. Interacts with ribosomal protein uL14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
messages: Interacts with ribosomal protein uL14 (rplN).

222136:BBW65 RS04280
gene id: 222136:BBW65_RS04280
uniprot id: A0A1B1U5J5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

222136:BBW65 RS06770
gene id: 222136:BBW65_RS06770
uniprot id: A0A1B1U6U5
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the HemJ family.
messages: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
messages: Catalyzes the oxidation of protoporphyrinogen IX to protoporphyrin IX.
messages: Cell membrane
messages: Homodimer.
messages: Membrane

222136:BBW65 RS06200
gene id: 222136:BBW65_RS06200
uniprot id: A0A1B1U6N8
names: Similarity
messages: Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.

222136:BBW65 RS04290
gene id: 222136:BBW65_RS04290
uniprot id: A0A1B1U5N4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

222136:BBW65 RS07170
gene id: 222136:BBW65_RS07170
uniprot id: A0A1B1U714
names: Function
names: Similarity
messages: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
messages: Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.

222136:BBW65 RS02080
gene id: 222136:BBW65_RS02080
uniprot id: A0A1B1U4I5
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

222136:BBW65 RS01295
gene id: 222136:BBW65_RS01295
uniprot id: A0A1B1U411
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

222136:BBW65 RS00185
gene id: 222136:BBW65_RS00185
uniprot id: A0A1B1U3I3
names: Similarity
messages: Belongs to the acyl coenzyme A hydrolase family.

222136:BBW65 RS01555
gene id: 222136:BBW65_RS01555
uniprot id: A0A1B1U483
names: Subcellular Location Annotation
messages: Membrane

222136:BBW65 RS04415
gene id: 222136:BBW65_RS04415
uniprot id: A0A1B1U5Q4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MurJ/MviN family.
messages: Cell membrane
messages: Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
messages: Membrane

222136:BBW65 RS06955
gene id: 222136:BBW65_RS06955
uniprot id: A0A1B1U6W5
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

222136:BBW65 RS06095
gene id: 222136:BBW65_RS06095
uniprot id: A0A1B1U6N5
names: Function
names: Similarity
messages: Belongs to the PEP-utilizing enzyme family.
messages: Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.

222136:BBW65 RS05365
gene id: 222136:BBW65_RS05365
uniprot id: A0A1B1U674
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

222136:BBW65 RS00620
gene id: 222136:BBW65_RS00620
uniprot id: A0A1B1U3S3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the HsdR family.
messages: Subunit R is required for both nuclease and ATPase activities, but not for modification.
messages: The type I restriction/modification system is composed of three polypeptides R, M and S.

222136:BBW65 RS00865
gene id: 222136:BBW65_RS00865
uniprot id: A0A1B1U3W7
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

222136:BBW65 RS05455
gene id: 222136:BBW65_RS05455
uniprot id: A0A1B1U653
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL17 family.
messages: Part of the 50S ribosomal subunit. Contacts protein L32.

222136:BBW65 RS06175
gene id: 222136:BBW65_RS06175
uniprot id: A0A1B1U6U4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase group 1 family.
messages: Cell membrane
messages: Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.

222136:BBW65 RS07730
gene id: 222136:BBW65_RS07730
uniprot id: A0A1B1U7E6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Cell inner membrane
messages: Homopentamer. In the absence of Mg(2+), interactions between subunits are weakened, and dimers, trimers and tetramers can be observed in vitro.
messages: Mediates influx of magnesium ions.
messages: Membrane

222136:BBW65 RS01495
gene id: 222136:BBW65_RS01495
uniprot id: A0A1B1U492
names: Function
names: Similarity
messages: Belongs to the MoeA family.
messages: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.

222136:BBW65 RS00385
gene id: 222136:BBW65_RS00385
uniprot id: A0A1B1U3N7
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

222136:BBW65 RS05340
gene id: 222136:BBW65_RS05340
uniprot id: A0A1B1U631
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

222136:BBW65 RS04520
gene id: 222136:BBW65_RS04520
uniprot id: A0A1B1U5S4
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the tRNA(Ile)-lysidine synthase family.
messages: Cytoplasm
messages: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
messages: The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.

222136:BBW65 RS05465
gene id: 222136:BBW65_RS05465
uniprot id: A0A1B1U690
names: Similarity
messages: Belongs to the GSP E family.

222136:BBW65 RS06775
gene id: 222136:BBW65_RS06775
uniprot id: A0A1B1U6U3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thiolase-like superfamily. FabH family.
messages: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
messages: Cytoplasm
messages: Homodimer.
messages: The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.

222136:BBW65 RS05330
gene id: 222136:BBW65_RS05330
uniprot id: A0A1B1U6C5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

222136:BBW65 RS02785
gene id: 222136:BBW65_RS02785
uniprot id: A0A1B1U4U5
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
messages: Binds 2 magnesium ions per tetramer.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

222136:BBW65 RS05425
gene id: 222136:BBW65_RS05425
uniprot id: A0A1B1U6B6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

222136:BBW65 RS05255
gene id: 222136:BBW65_RS05255
uniprot id: A0A1B1U657
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GTP-binding SRP family. FtsY subfamily.
messages: Cell membrane
messages: Cytoplasm
messages: Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
messages: Membrane
messages: Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.

222136:BBW65 RS02765
gene id: 222136:BBW65_RS02765
uniprot id: A0A1B1U4W2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

222136:BBW65 RS00425
gene id: 222136:BBW65_RS00425
uniprot id: A0A1B1U7D9
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

222136:BBW65 RS04405
gene id: 222136:BBW65_RS04405
uniprot id: A0A1B1U5L5
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvA family.
messages: Cytoplasm
messages: Has three domains with a flexible linker between the domains II and III and assumes an 'L' shape. Domain III is highly mobile and contacts RuvB.
messages: Homotetramer. Forms an RuvA(8)-RuvB(12)-Holliday junction (HJ) complex. HJ DNA is sandwiched between 2 RuvA tetramers; dsDNA enters through RuvA and exits via RuvB. An RuvB hexamer assembles on each DNA strand where it exits the tetramer. Each RuvB hexamer is contacted by two RuvA subunits (via domain III) on 2 adjacent RuvB subunits; this complex drives branch migration. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). RuvA specifically binds to HJ cruciform DNA, conferring on it an open structure. The RuvB hexamer acts as an ATP-dependent pump, pulling dsDNA into and through the RuvAB complex. HJ branch migration allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

222136:BBW65 RS00215
gene id: 222136:BBW65_RS00215
uniprot id: A0A1B1U7I1
names: Similarity
messages: Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily.

222136:BBW65 RS00110
gene id: 222136:BBW65_RS00110
uniprot id: A0A1B1U3I5
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

222136:BBW65 RS05430
gene id: 222136:BBW65_RS05430
uniprot id: A0A1B1U6E8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL36 family.

222136:BBW65 RS07375
gene id: 222136:BBW65_RS07375
uniprot id: A0A1B1U750
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.
messages: This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.

222136:BBW65 RS07400
gene id: 222136:BBW65_RS07400
uniprot id: A0A1B1U7G7
names: Similarity
messages: Belongs to the TlyA family.

222136:BBW65 RS03885
gene id: 222136:BBW65_RS03885
uniprot id: A0A1B1U5I8
names: Function
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.
messages: Reversible hydration of carbon dioxide.

222136:BBW65 RS04270
gene id: 222136:BBW65_RS04270
uniprot id: A0A1B1U5U5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

222136:BBW65 RS04285
gene id: 222136:BBW65_RS04285
uniprot id: A0A1B1U5N9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL10 family.
messages: Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

222136:BBW65 RS03500
gene id: 222136:BBW65_RS03500
uniprot id: A0A1B1U5B5
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

222136:BBW65 RS00835
gene id: 222136:BBW65_RS00835
uniprot id: A0A1B1U3U4
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

222136:BBW65 RS05440
gene id: 222136:BBW65_RS05440
uniprot id: A0A1B1U651
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

222136:BBW65 RS06195
gene id: 222136:BBW65_RS06195
uniprot id: A0A1B1U6L8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
messages: Membrane

222136:BBW65 RS02245
gene id: 222136:BBW65_RS02245
uniprot id: A0A1B1U4L5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

222136:BBW65 RS02915
gene id: 222136:BBW65_RS02915
uniprot id: A0A1B1U4Z3
names: Subcellular Location Annotation
messages: Cell inner membrane
messages: Membrane

222136:BBW65 RS01610
gene id: 222136:BBW65_RS01610
uniprot id: A0A1B1U494
names: Caution
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS00960
gene id: 222136:BBW65_RS00960
uniprot id: A0A1B1U3Y0
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

222136:BBW65 RS01220
gene id: 222136:BBW65_RS01220
uniprot id: A0A1B1U7G8
names: Similarity
messages: Belongs to the mannose-6-phosphate isomerase type 2 family.

222136:BBW65 RS05390
gene id: 222136:BBW65_RS05390
uniprot id: A0A1B1U641
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

222136:BBW65 RS05445
gene id: 222136:BBW65_RS05445
uniprot id: A0A1B1U6G4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

222136:BBW65 RS02910
gene id: 222136:BBW65_RS02910
uniprot id: A0A1B1U4V3
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

222136:BBW65 RS06495
gene id: 222136:BBW65_RS06495
uniprot id: A0A1B1U6V4
names: Function
names: Similarity
messages: Belongs to the PurU family.
messages: Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).

222136:BBW65 RS00095
gene id: 222136:BBW65_RS00095
uniprot id: A0A1B1U7D6
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

222136:BBW65 RS04725
gene id: 222136:BBW65_RS04725
uniprot id: A0A1B1U7N9
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

222136:BBW65 RS00795
gene id: 222136:BBW65_RS00795
uniprot id: A0A1B1U3W0
names: Similarity
messages: Belongs to the LacAB/RpiB family.

222136:BBW65 RS06675
gene id: 222136:BBW65_RS06675
uniprot id: A0A1B1U732
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
messages: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
messages: Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
messages: Cytoplasm
messages: Homodimer. The tRNA molecule binds across the dimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS03000
gene id: 222136:BBW65_RS03000
uniprot id: A0A1B1U554
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

222136:BBW65 RS03190
gene id: 222136:BBW65_RS03190
uniprot id: A0A1B1U501
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UvrB family.
messages: Cytoplasm
messages: Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
messages: The beta-hairpin motif is involved in DNA binding.

222136:BBW65 RS04665
gene id: 222136:BBW65_RS04665
uniprot id: A0A1B1U617
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
messages: Cell membrane

222136:BBW65 RS03735
gene id: 222136:BBW65_RS03735
uniprot id: A0A1B1U5B6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

222136:BBW65 RS01895
gene id: 222136:BBW65_RS01895
uniprot id: A0A1B1U4E7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
messages: Belongs to the CsrA/RsmA family.
messages: Cytoplasm
messages: Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.

222136:BBW65 RS04365
gene id: 222136:BBW65_RS04365
uniprot id: A0A1B1U5P4
names: Similarity
messages: Belongs to the thioredoxin family.

222136:BBW65 RS05885
gene id: 222136:BBW65_RS05885
uniprot id: A0A1B1U6H4
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Reduced FMN (FMNH(2)).

222136:BBW65 RS03490
gene id: 222136:BBW65_RS03490
uniprot id: A0A1B1U585
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.
messages: Cytoplasm
messages: Homodimer.

222136:BBW65 RS05495
gene id: 222136:BBW65_RS05495
uniprot id: A0A1B1U661
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

222136:BBW65 RS02125
gene id: 222136:BBW65_RS02125
uniprot id: A0A1B1U4Q2
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

222136:BBW65 RS03005
gene id: 222136:BBW65_RS03005
uniprot id: A0A1B1U4Y5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IPP transferase family.
messages: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

222136:BBW65 RS06895
gene id: 222136:BBW65_RS06895
uniprot id: A0A1B1U6V6
names: Caution
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FBPase class 1 family.
messages: Binds 2 magnesium ions per subunit.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS03595
gene id: 222136:BBW65_RS03595
uniprot id: A0A1B1U566
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the complex I 20 kDa subunit family.
messages: Binds 1 [4Fe-4S] cluster.
messages: Cell membrane
messages: NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.

222136:BBW65 RS01340
gene id: 222136:BBW65_RS01340
uniprot id: A0A1B1U447
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the transketolase family.
messages: Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).
messages: Binds 1 thiamine pyrophosphate per subunit.
messages: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
messages: Homodimer.

222136:BBW65 RS00280
gene id: 222136:BBW65_RS00280
uniprot id: A0A1B1U3M9
names: Similarity
messages: Belongs to the FPP/GGPP synthase family.

222136:BBW65 RS00505
gene id: 222136:BBW65_RS00505
uniprot id: A0A1B1U3S0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase C chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
messages: Membrane

222136:BBW65 RS05950
gene id: 222136:BBW65_RS05950
uniprot id: A0A1B1U6E1
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the glycosyltransferase 4 family. MraY subfamily.
messages: Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
messages: Cell membrane
messages: Membrane

222136:BBW65 RS03010
gene id: 222136:BBW65_RS03010
uniprot id: A0A1B1U4V8
names: Subcellular Location Annotation
messages: Membrane

222136:BBW65 RS02180
gene id: 222136:BBW65_RS02180
uniprot id: A0A1B1U4R6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.
messages: Secreted

222136:BBW65 RS03185
gene id: 222136:BBW65_RS03185
uniprot id: A0A1B1U531
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PdxA family.
messages: Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
messages: Cytoplasm
messages: Homodimer.
messages: The active site is located at the dimer interface.

222136:BBW65 RS07570
gene id: 222136:BBW65_RS07570
uniprot id: A0A1B1U797
names: Function
names: Similarity
messages: Belongs to the TenA family.
messages: Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.

222136:BBW65 RS05375
gene id: 222136:BBW65_RS05375
uniprot id: A0A1B1U6A6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

222136:BBW65 RS01510
gene id: 222136:BBW65_RS01510
uniprot id: A0A1B1U452
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MoaC family.
messages: Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
messages: Homohexamer; trimer of dimers.

222136:BBW65 RS01770
gene id: 222136:BBW65_RS01770
uniprot id: A0A1B1U4D6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type-II 3-dehydroquinase family.
messages: Catalyzes a trans-dehydration via an enolate intermediate.
messages: Homododecamer.

222136:BBW65 RS03160
gene id: 222136:BBW65_RS03160
uniprot id: A0A1B1U7M1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Membrane

222136:BBW65 RS06185
gene id: 222136:BBW65_RS06185
uniprot id: A0A1B1U6I3
names: Similarity
messages: Belongs to the GTP cyclohydrolase I type 2/NIF3 family.

222136:BBW65 RS00290
gene id: 222136:BBW65_RS00290
uniprot id: A0A1B1U3P6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the YbaB/EbfC family.
messages: Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
messages: Homodimer.
messages: nucleoid

222136:BBW65 RS06940
gene id: 222136:BBW65_RS06940
uniprot id: A0A1B1U6X6
names: Function
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

222136:BBW65 RS00935
gene id: 222136:BBW65_RS00935
uniprot id: A0A1B1U441
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
messages: Cell membrane
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

222136:BBW65 RS04145
gene id: 222136:BBW65_RS04145
uniprot id: A0A1B1U5R7
names: Cofactor
names: Function
names: Similarity
messages: Binds 1 Mg(2+) ion per subunit.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
messages: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

222136:BBW65 RS02725
gene id: 222136:BBW65_RS02725
uniprot id: A0A1B1U4W7
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
messages: Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.
messages: Cytoplasm

222136:BBW65 RS02795
gene id: 222136:BBW65_RS02795
uniprot id: A0A1B1U534
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the IspH family.
messages: Binds 1 [4Fe-4S] cluster per subunit.
messages: Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.

222136:BBW65 RS06765
gene id: 222136:BBW65_RS06765
uniprot id: A0A1B1U737
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
messages: Cytoplasm

222136:BBW65 RS00455
gene id: 222136:BBW65_RS00455
uniprot id: A0A1B1U3T0
names: Similarity
messages: Belongs to the glycosyltransferase 10 family.

222136:BBW65 RS06055
gene id: 222136:BBW65_RS06055
uniprot id: A0A1B1U6G1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the Dps family.
messages: Cytoplasm

222136:BBW65 RS07200
gene id: 222136:BBW65_RS07200
uniprot id: A0A1B1U733
names: Similarity
messages: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.

222136:BBW65 RS01660
gene id: 222136:BBW65_RS01660
uniprot id: A0A1B1U4A3
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

222136:BBW65 RS04705
gene id: 222136:BBW65_RS04705
uniprot id: A0A1B1U616
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NifU family.
messages: Binds 1 Fe cation per subunit.
messages: Binds 1 [2Fe-2S] cluster per subunit.
messages: May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.

222136:BBW65 RS03705
gene id: 222136:BBW65_RS03705
uniprot id: A0A1B1U5C8
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

222136:BBW65 RS00590
gene id: 222136:BBW65_RS00590
uniprot id: A0A1B1U3N3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

222136:BBW65 RS06395
gene id: 222136:BBW65_RS06395
uniprot id: A0A1B1U6M6
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL27 family.

222136:BBW65 RS07295
gene id: 222136:BBW65_RS07295
uniprot id: A0A1B1U7E7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SHMT family.
messages: Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
messages: Cytoplasm
messages: Homodimer.

222136:BBW65 RS04950
gene id: 222136:BBW65_RS04950
uniprot id: A0A1B1U5V9
names: Similarity
messages: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

222136:BBW65 RS04920
gene id: 222136:BBW65_RS04920
uniprot id: A0A1B1U655
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

222136:BBW65 RS03935
gene id: 222136:BBW65_RS03935
uniprot id: A0A1B1U5J9
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

222136:BBW65 RS00785
gene id: 222136:BBW65_RS00785
uniprot id: A0A1B1U3T4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Membrane

222136:BBW65 RS04450
gene id: 222136:BBW65_RS04450
uniprot id: A0A1B1U5R2
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
messages: Belongs to the AAA ATPase family.
messages: Binds 1 zinc ion per subunit.
messages: Cell membrane
messages: Homohexamer.
messages: In the C-terminal section; belongs to the peptidase M41 family.
messages: In the central section; belongs to the AAA ATPase family.

222136:BBW65 RS02660
gene id: 222136:BBW65_RS02660
uniprot id: A0A1B1U4U1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecD subfamily.
messages: Cell membrane
messages: Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

222136:BBW65 RS07725
gene id: 222136:BBW65_RS07725
uniprot id: A0A1B1U3I5
names: Caution
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the phosphoglycerate kinase family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

222136:BBW65 RS04885
gene id: 222136:BBW65_RS04885
uniprot id: A0A1B1U660
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RuvC family.
messages: Binds 2 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homodimer which binds Holliday junction (HJ) DNA. The HJ becomes 2-fold symmetrical on binding to RuvC with unstacked arms; it has a different conformation from HJ DNA in complex with RuvA. In the full resolvosome a probable DNA-RuvA(4)-RuvB(12)-RuvC(2) complex forms which resolves the HJ.
messages: The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair. Endonuclease that resolves HJ intermediates. Cleaves cruciform DNA by making single-stranded nicks across the HJ at symmetrical positions within the homologous arms, yielding a 5'-phosphate and a 3'-hydroxyl group; requires a central core of homology in the junction. The consensus cleavage sequence is 5'-(A/T)TT(C/G)-3'. Cleavage occurs on the 3'-side of the TT dinucleotide at the point of strand exchange. HJ branch migration catalyzed by RuvA-RuvB allows RuvC to scan DNA until it finds its consensus sequence, where it cleaves and resolves the cruciform DNA.

222136:BBW65 RS02380
gene id: 222136:BBW65_RS02380
uniprot id: A0A1B1U4Q6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the acetokinase family.
messages: Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mg(2+). Can also accept Mn(2+).

222136:BBW65 RS04370
gene id: 222136:BBW65_RS04370
uniprot id: A0A1B1U5Q3
names: Similarity
messages: Belongs to the UPF0102 family.

222136:BBW65 RS05890
gene id: 222136:BBW65_RS05890
uniprot id: A0A1B1U6G8
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanB family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
messages: Cytoplasm
messages: Homodecamer; pentamer of dimers.

222136:BBW65 RS00315
gene id: 222136:BBW65_RS00315
uniprot id: A0A1B1U3L2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
messages: Membrane

222136:BBW65 RS02610
gene id: 222136:BBW65_RS02610
uniprot id: A0A1B1U4S8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TonB family.
messages: Cell inner membrane

222136:BBW65 RS02335
gene id: 222136:BBW65_RS02335
uniprot id: A0A1B1U4L8
names: Subcellular Location Annotation
messages: Membrane

222136:BBW65 RS03395
gene id: 222136:BBW65_RS03395
uniprot id: A0A1B1U593
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.
messages: Cell membrane
messages: Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
messages: Membrane
messages: Na(+) is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

222136:BBW65 RS04395
gene id: 222136:BBW65_RS04395
uniprot id: A0A1B1U5W5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. RsmI family.
messages: Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
messages: Cytoplasm

222136:BBW65 RS00780
gene id: 222136:BBW65_RS00780
uniprot id: A0A1B1U3V5
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
messages: Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS06700
gene id: 222136:BBW65_RS06700
uniprot id: A0A1B1U6V8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

222136:BBW65 RS02600
gene id: 222136:BBW65_RS02600
uniprot id: A0A1B1U4T1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliN/MopA/SpaO family.
messages: Membrane

222136:BBW65 RS01500
gene id: 222136:BBW65_RS01500
uniprot id: A0A1B1U4B5
names: Caution
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the GTP cyclohydrolase II family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS07210
gene id: 222136:BBW65_RS07210
uniprot id: A0A1B1U7E4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
messages: Could methylate the ribose at the nucleotide 34 wobble position in tRNA.
messages: Cytoplasm

222136:BBW65 RS02005
gene id: 222136:BBW65_RS02005
uniprot id: A0A1B1U4G5
names: Similarity
names: Subunit
messages: Belongs to the peptidase M20A family. DapE subfamily.
messages: Homodimer.

222136:BBW65 RS04265
gene id: 222136:BBW65_RS04265
uniprot id: A0A1B1U5J1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

222136:BBW65 RS01580
gene id: 222136:BBW65_RS01580
uniprot id: A0A1B1U4A2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FliS family.
messages: cytosol

222136:BBW65 RS06595
gene id: 222136:BBW65_RS06595
uniprot id: A0A1B1U724
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Homodimer.

222136:BBW65 RS06580
gene id: 222136:BBW65_RS06580
uniprot id: A0A1B1U6R0
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

222136:BBW65 RS02495
gene id: 222136:BBW65_RS02495
uniprot id: A0A1B1U4W0
names: Similarity
messages: Belongs to the DegT/DnrJ/EryC1 family.

222136:BBW65 RS04255
gene id: 222136:BBW65_RS04255
uniprot id: A0A1B1U5T7
names: Function
names: Similarity
messages: Belongs to the flavodoxin family.
messages: Low-potential electron donor to a number of redox enzymes.

222136:BBW65 RS05955
gene id: 222136:BBW65_RS05955
uniprot id: A0A1B1U6I1
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EPSP synthase family. MurA subfamily.
messages: Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS04150
gene id: 222136:BBW65_RS04150
uniprot id: A0A1B1U5J3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the AIR synthase family.
messages: Cytoplasm

222136:BBW65 RS04845
gene id: 222136:BBW65_RS04845
uniprot id: A0A1B1U5U8
names: Function
names: Subcellular Location Annotation
names: Subunit
messages: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
messages: Cytoplasm
messages: Homodimer.

222136:BBW65 RS04760
gene id: 222136:BBW65_RS04760
uniprot id: A0A1B1U626
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

222136:BBW65 RS06645
gene id: 222136:BBW65_RS06645
uniprot id: A0A1B1U6Z2
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MnmA/TRMU family.
messages: Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS02960
gene id: 222136:BBW65_RS02960
uniprot id: A0A1B1U7R0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS16 family.

222136:BBW65 RS07020
gene id: 222136:BBW65_RS07020
uniprot id: A0A1B1U738
names: Similarity
messages: Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.

222136:BBW65 RS01860
gene id: 222136:BBW65_RS01860
uniprot id: A0A1B1U4E9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0161 family.
messages: Cell membrane
messages: Could be involved in insertion of integral membrane proteins into the membrane.

222136:BBW65 RS05165
gene id: 222136:BBW65_RS05165
uniprot id: A0A1B1U647
names: Similarity
messages: Belongs to the XseB family.

222136:BBW65 RS01285
gene id: 222136:BBW65_RS01285
uniprot id: A0A1B1U7P0
names: Cofactor
names: Similarity
messages: Belongs to the malic enzymes family.
messages: Divalent metal cations. Prefers magnesium or manganese.

222136:BBW65 RS02485
gene id: 222136:BBW65_RS02485
uniprot id: A0A1B1U4S5
names: Subunit
messages: The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

222136:BBW65 RS01050
gene id: 222136:BBW65_RS01050
uniprot id: A0A1B1U407
names: Cofactor
names: Function
names: Miscellaneous
names: Similarity
names: Subunit
messages: Belongs to the HMBS family.
messages: Binds 1 dipyrromethane group covalently.
messages: Monomer.
messages: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
messages: The porphobilinogen subunits are added to the dipyrromethane group.

222136:BBW65 RS07710
gene id: 222136:BBW65_RS07710
uniprot id: A0A1B1U7D6
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

222136:BBW65 RS03550
gene id: 222136:BBW65_RS03550
uniprot id: A0A1B1U594
names: Subcellular Location Annotation
messages: Membrane

222136:BBW65 RS02240
gene id: 222136:BBW65_RS02240
uniprot id: A0A1B1U4S6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
messages: Cell membrane
messages: Membrane

222136:BBW65 RS01845
gene id: 222136:BBW65_RS01845
uniprot id: A0A1B1U4D7
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.
messages: Binds 1 potassium ion per subunit.
messages: Cytoplasm
messages: Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
messages: Homodimer. Heterotetramer of two MnmE and two MnmG subunits.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS00925
gene id: 222136:BBW65_RS00925
uniprot id: A0A1B1U3V2
names: Function
messages: Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

222136:BBW65 RS04260
gene id: 222136:BBW65_RS04260
uniprot id: A0A1B1U5L2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

222136:BBW65 RS00295
gene id: 222136:BBW65_RS00295
uniprot id: A0A1B1U3L4
names: Cofactor
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PanD family.
messages: Binds 1 pyruvoyl group covalently per subunit.
messages: Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
messages: Cytoplasm
messages: Heterooctamer of four alpha and four beta subunits.
messages: Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.

222136:BBW65 RS04765
gene id: 222136:BBW65_RS04765
uniprot id: A0A1B1U5U6
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

222136:BBW65 RS00275
gene id: 222136:BBW65_RS00275
uniprot id: A0A1B1U3M0
names: Function
names: Similarity
messages: Belongs to the NadD family.
messages: Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).

222136:BBW65 RS07365
gene id: 222136:BBW65_RS07365
uniprot id: A0A1B1U7H7
names: Subcellular Location Annotation
messages: Membrane

222136:BBW65 RS00465
gene id: 222136:BBW65_RS00465
uniprot id: A0A1B1U3P9
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribonucleoside diphosphate reductase small chain family.
messages: Binds 2 iron ions per subunit.
messages: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.

222136:BBW65 RS03695
gene id: 222136:BBW65_RS03695
uniprot id: A0A1B1U5C2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane

222136:BBW65 RS04080
gene id: 222136:BBW65_RS04080
uniprot id: A0A1B1U5J4
names: Similarity
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.

222136:BBW65 RS03240
gene id: 222136:BBW65_RS03240
uniprot id: A0A1B1U511
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecA family.
messages: Cell membrane
messages: Cytoplasm
messages: Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

222136:BBW65 RS03020
gene id: 222136:BBW65_RS03020
uniprot id: A0A1B1U504
names: Cofactor
names: Similarity
messages: Belongs to the peptidase M48 family.
messages: Binds 1 zinc ion per subunit.

222136:BBW65 RS03085
gene id: 222136:BBW65_RS03085
uniprot id: A0A1B1U516
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TsaE family.
messages: Cytoplasm

222136:BBW65 RS04690
gene id: 222136:BBW65_RS04690
uniprot id: A0A1B1U5V3
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FKBP-type PPIase family. Tig subfamily.
messages: Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.
messages: Cytoplasm
messages: Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.

222136:BBW65 RS03365
gene id: 222136:BBW65_RS03365
uniprot id: A0A1B1U5D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the acetylglutamate kinase family. ArgB subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
messages: Cytoplasm

222136:BBW65 RS06725
gene id: 222136:BBW65_RS06725
uniprot id: A0A1B1U6T2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the hcp beta-lactamase family.
messages: Hydrolyzes 6-aminopenicillinic acid and 7-aminocephalosporanic acid (ACA) derivatives.
messages: Secreted

222136:BBW65 RS01915
gene id: 222136:BBW65_RS01915
uniprot id: A0A1B1U4D0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RimP family.
messages: Cytoplasm
messages: Required for maturation of 30S ribosomal subunits.

222136:BBW65 RS00635
gene id: 222136:BBW65_RS00635
uniprot id: A0A1B1U3S4
names: Similarity
messages: Belongs to the type-I restriction system S methylase family.

222136:BBW65 RS01855
gene id: 222136:BBW65_RS01855
uniprot id: A0A1B1U4K3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
messages: Cell membrane
messages: Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.
messages: Membrane
messages: Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.

222136:BBW65 RS01010
gene id: 222136:BBW65_RS01010
uniprot id: A0A1B1U3Z9
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

222136:BBW65 RS04050
gene id: 222136:BBW65_RS04050
uniprot id: A0A1B1U5H3
names: Subcellular Location Annotation
messages: Membrane

222136:BBW65 RS06720
gene id: 222136:BBW65_RS06720
uniprot id: A0A1B1U6T1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

222136:BBW65 RS04875
gene id: 222136:BBW65_RS04875
uniprot id: A0A1B1U5W8
names: Cofactor
names: Similarity
messages: Belongs to the DNA repair enzymes AP/ExoA family.
messages: Probably binds two magnesium or manganese ions per subunit.

222136:BBW65 RS00685
gene id: 222136:BBW65_RS00685
uniprot id: A0A1B1U3X2
names: Similarity
messages: Belongs to the diaminopimelate epimerase family.

222136:BBW65 RS06490
gene id: 222136:BBW65_RS06490
uniprot id: A0A1B1U707
names: Similarity
messages: Belongs to the FKBP-type PPIase family.

222136:BBW65 RS02320
gene id: 222136:BBW65_RS02320
uniprot id: A0A1B1U4M9
names: Similarity
messages: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.

222136:BBW65 RS06155
gene id: 222136:BBW65_RS06155
uniprot id: A0A1B1U6P6
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Cytoplasm
messages: Homodimer.
messages: Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS07520
gene id: 222136:BBW65_RS07520
uniprot id: A0A1B1U7K4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

222136:BBW65 RS06545
gene id: 222136:BBW65_RS06545
uniprot id: A0A1B1U6W4
names: Similarity
names: Subunit
messages: Belongs to the CarA family.
messages: Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.

222136:BBW65 RS06855
gene id: 222136:BBW65_RS06855
uniprot id: A0A1B1U713
names: Similarity
messages: Belongs to the aspartokinase family.

222136:BBW65 RS04620
gene id: 222136:BBW65_RS04620
uniprot id: A0A1B1U5U1
names: Function
names: Similarity
messages: Belongs to the LpxC family.
messages: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.

222136:BBW65 RS03585
gene id: 222136:BBW65_RS03585
uniprot id: A0A1B1U5H1
names: Cofactor
names: Similarity
messages: Belongs to the complex I 24 kDa subunit family.
messages: Binds 1 [2Fe-2S] cluster.

222136:BBW65 RS04655
gene id: 222136:BBW65_RS04655
uniprot id: A0A1B1U5T0
names: Similarity
messages: Belongs to the class-I fumarase family.

222136:BBW65 RS02230
gene id: 222136:BBW65_RS02230
uniprot id: A0A1B1U4J9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

222136:BBW65 RS01465
gene id: 222136:BBW65_RS01465
uniprot id: A0A1B1U4C1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
messages: Cytoplasm

222136:BBW65 RS05005
gene id: 222136:BBW65_RS05005
uniprot id: A0A1B1U684
names: Similarity
messages: Belongs to the ketol-acid reductoisomerase family.

222136:BBW65 RS04880
gene id: 222136:BBW65_RS04880
uniprot id: A0A1B1U5V1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the thymidylate synthase ThyX family.
messages: Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS02145
gene id: 222136:BBW65_RS02145
uniprot id: A0A1B1U4K1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
messages: Cytoplasm

222136:BBW65 RS00220
gene id: 222136:BBW65_RS00220
uniprot id: A0A1B1U3L5
names: Similarity
messages: Belongs to the MotB family.

222136:BBW65 RS00870
gene id: 222136:BBW65_RS00870
uniprot id: A0A1B1U3U2
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Rho family.
messages: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
messages: Homohexamer. The homohexamer assembles into an open ring structure.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

222136:BBW65 RS01900
gene id: 222136:BBW65_RS01900
uniprot id: A0A1B1U4B4
names: Function
names: Similarity
messages: Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
messages: Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.

222136:BBW65 RS04295
gene id: 222136:BBW65_RS04295
uniprot id: A0A1B1U5P2
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

222136:BBW65 RS05830
gene id: 222136:BBW65_RS05830
uniprot id: A0A1B1U6F7
names: Subcellular Location Annotation
messages: Cytoplasm

222136:BBW65 RS05265
gene id: 222136:BBW65_RS05265
uniprot id: A0A1B1U666
names: Similarity
messages: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

222136:BBW65 RS04645
gene id: 222136:BBW65_RS04645
uniprot id: A0A1B1U5X7
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the radical SAM superfamily. MqnE family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.

222136:BBW65 RS02655
gene id: 222136:BBW65_RS02655
uniprot id: A0A1B1U4U2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the SecD/SecF family. SecF subfamily.
messages: Cell membrane
messages: Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.
messages: Membrane
messages: Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.

222136:BBW65 RS06830
gene id: 222136:BBW65_RS06830
uniprot id: A0A1B1U765
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

222136:BBW65 RS07430
gene id: 222136:BBW65_RS07430
uniprot id: A0A1B1U791
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
messages: Cytoplasm
messages: Homodimer.

222136:BBW65 RS00190
gene id: 222136:BBW65_RS00190
uniprot id: A0A1B1U3R8
names: Cofactor
names: Similarity
messages: Belongs to the class-II DAHP synthase family.
messages: Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.

222136:BBW65 RS05335
gene id: 222136:BBW65_RS05335
uniprot id: A0A1B1U642
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

222136:BBW65 RS04085
gene id: 222136:BBW65_RS04085
uniprot id: A0A1B1U5K2
names: Subcellular Location Annotation
messages: Membrane

222136:BBW65 RS06785
gene id: 222136:BBW65_RS06785
uniprot id: A0A1B1U701
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

222136:BBW65 RS07360
gene id: 222136:BBW65_RS07360
uniprot id: A0A1B1U755
names: Function
names: Similarity
names: Subunit
messages: Belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
messages: Homodimer.
messages: In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.
messages: In the N-terminal section; belongs to the MIP18 family.

222136:BBW65 RS01880
gene id: 222136:BBW65_RS01880
uniprot id: A0A1B1U4E4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the exbB/tolQ family.
messages: Cell inner membrane
messages: Membrane

222136:BBW65 RS07160
gene id: 222136:BBW65_RS07160
uniprot id: A0A1B1U7D5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

222136:BBW65 RS06280
gene id: 222136:BBW65_RS06280
uniprot id: A0A1B1U6R5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

222136:BBW65 RS04360
gene id: 222136:BBW65_RS04360
uniprot id: A0A1B1U5P9
names: Cofactor
names: Similarity
names: Subunit
messages: Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.
messages: Binds 1 FAD per subunit.
messages: Homodimer.

222136:BBW65 RS00715
gene id: 222136:BBW65_RS00715
uniprot id: A0A1B1U7C5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CoaE family.
messages: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
messages: Cytoplasm

222136:BBW65 RS01525
gene id: 222136:BBW65_RS01525
uniprot id: A0A1B1U463
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

222136:BBW65 RS01810
gene id: 222136:BBW65_RS01810
uniprot id: A0A1B1U4B0
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-II aminoacyl-tRNA synthetase family.
messages: Cytoplasm
messages: Tetramer of two alpha and two beta subunits.

222136:BBW65 RS02195
gene id: 222136:BBW65_RS02195
uniprot id: A0A1B1U4K5
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Bacterial flagellum basal body
messages: Belongs to the flagella basal body rod proteins family.
messages: The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.

222136:BBW65 RS07480
gene id: 222136:BBW65_RS07480
uniprot id: A0A1B1U7A4
names: Function
names: Similarity
messages: Belongs to the DXR family.
messages: Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).

222136:BBW65 RS03530
gene id: 222136:BBW65_RS03530
uniprot id: A0A1B1U591
names: Cofactor
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DnaJ family.
messages: Binds 2 Zn(2+) ions per monomer.
messages: Cytoplasm
messages: Homodimer.
messages: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
messages: The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.

222136:BBW65 RS05385
gene id: 222136:BBW65_RS05385
uniprot id: A0A1B1U652
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.
messages: Binds 1 zinc ion per subunit.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

222136:BBW65 RS04445
gene id: 222136:BBW65_RS04445
uniprot id: A0A1B1U5X5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the methyltransferase superfamily. PrmA family.
messages: Cytoplasm
messages: Methylates ribosomal protein L11.

222136:BBW65 RS06310
gene id: 222136:BBW65_RS06310
uniprot id: A0A1B1U6W0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the guanylate kinase family.
messages: Cytoplasm
messages: Essential for recycling GMP and indirectly, cGMP.

222136:BBW65 RS02895
gene id: 222136:BBW65_RS02895
uniprot id: A0A1B1U4T9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the helicase family. PriA subfamily.
messages: Component of the primosome.
messages: Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.

222136:BBW65 RS04090
gene id: 222136:BBW65_RS04090
uniprot id: A0A1B1U5M8
names: Similarity
messages: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

222136:BBW65 RS03660
gene id: 222136:BBW65_RS03660
uniprot id: A0A1B1U5B3
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TatC family.
messages: Cell membrane
messages: Forms a complex with TatA.
messages: Membrane
messages: Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes.

222136:BBW65 RS07250
gene id: 222136:BBW65_RS07250
uniprot id: A0A1B1U743
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseA family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

222136:BBW65 RS06445
gene id: 222136:BBW65_RS06445
uniprot id: A0A1B1U6U1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

222136:BBW65 RS05325
gene id: 222136:BBW65_RS05325
uniprot id: A0A1B1U696
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL4 family.
messages: Forms part of the polypeptide exit tunnel.
messages: One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.
messages: Part of the 50S ribosomal subunit.

222136:BBW65 RS02490
gene id: 222136:BBW65_RS02490
uniprot id: A0A1B1U7J6
names: Similarity
messages: Belongs to the NAD synthetase family.

222136:BBW65 RS02480
gene id: 222136:BBW65_RS02480
uniprot id: A0A1B1U4Q8
names: Subcellular Location Annotation
messages: Membrane

222136:BBW65 RS02265
gene id: 222136:BBW65_RS02265
uniprot id: A0A1B1U4L9
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

222136:BBW65 RS07720
gene id: 222136:BBW65_RS07720
uniprot id: A0A1B1U7G9
names: Similarity
messages: Belongs to the GPI family.

222136:BBW65 RS01475
gene id: 222136:BBW65_RS01475
uniprot id: A0A1B1U454
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the anaerobic coproporphyrinogen-III oxidase family.
messages: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
messages: Cytoplasm
messages: Monomer.

222136:BBW65 RS02345
gene id: 222136:BBW65_RS02345
uniprot id: A0A1B1U4U6
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the IMPDH/GMPR family.
messages: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.

222136:BBW65 RS03560
gene id: 222136:BBW65_RS03560
uniprot id: A0A1B1U5C4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the complex I subunit 6 family.
messages: Cell membrane
messages: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.