1917441:SR187 RS05500
gene id: 1917441:SR187_RS05500
uniprot id: A0A2Z5TN41
names: Cofactor
messages: Binds 1 zinc ion per subunit.

1917441:SR187 RS08180
gene id: 1917441:SR187_RS08180
uniprot id: A0A2Z5U0Q8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the NusA family.
messages: Cytoplasm
messages: Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.
messages: Participates in both transcription termination and antitermination.

1917441:SR187 RS05995
gene id: 1917441:SR187_RS05995
uniprot id: A0A2Z5TNJ5
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the chorismate synthase family.
messages: Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
messages: Homotetramer.
messages: Reduced FMN (FMNH(2)).

1917441:SR187 RS04125
gene id: 1917441:SR187_RS04125
uniprot id: A0A2Z5TQ43
names: Similarity
messages: Belongs to the UPF0758 family.

1917441:SR187 RS08750
gene id: 1917441:SR187_RS08750
uniprot id: A0A2Z5TQW4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
messages: Belongs to the EF-Ts family.
messages: Cytoplasm

1917441:SR187 RS09715
gene id: 1917441:SR187_RS09715
uniprot id: A0A2Z5TR28
names: Similarity
messages: Belongs to the iron-sulfur dependent L-serine dehydratase family.

1917441:SR187 RS06350
gene id: 1917441:SR187_RS06350
uniprot id: A0A2Z5U053
names: Cofactor
names: Function
names: PTM
names: Similarity
messages: Activated by phosphorylation.
messages: Belongs to the phosphohexose mutase family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.

1917441:SR187 RS02310
gene id: 1917441:SR187_RS02310
uniprot id: A0A2Z5TXG2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the FtsZ family.
messages: Cytoplasm
messages: Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
messages: Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.

1917441:SR187 RS00255
gene id: 1917441:SR187_RS00255
uniprot id: A0A2Z5U1Z8
names: Similarity
messages: Belongs to the SAICAR synthetase family.

1917441:SR187 RS06360
gene id: 1917441:SR187_RS06360
uniprot id: A0A2Z5U452
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the adenylate cyclase family. DacA/CdaA subfamily.
messages: Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Probably a homodimer.

1917441:SR187 RS00450
gene id: 1917441:SR187_RS00450
uniprot id: A0A2Z5TWL1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL3 family.
messages: One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.

1917441:SR187 RS05095
gene id: 1917441:SR187_RS05095
uniprot id: A0A2Z5TMS3
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.
messages: Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1917441:SR187 RS00510
gene id: 1917441:SR187_RS00510
uniprot id: A0A2Z5U247
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL5 family.
messages: Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.
messages: This is 1 of the proteins that bind and probably mediate the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.

1917441:SR187 RS05210
gene id: 1917441:SR187_RS05210
uniprot id: A0A2Z5U3S1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1917441:SR187 RS09820
gene id: 1917441:SR187_RS09820
uniprot id: A0A2Z5TTU7
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the RNA methyltransferase RlmH family.
messages: Cytoplasm
messages: Homodimer.
messages: Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.

1917441:SR187 RS02815
gene id: 1917441:SR187_RS02815
uniprot id: A0A2Z5TLF7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the SmpB family.
messages: Cytoplasm
messages: Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.

1917441:SR187 RS03620
gene id: 1917441:SR187_RS03620
uniprot id: A0A2Z5U346
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/UDP phosphorylase family.
messages: Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
messages: Homohexamer; trimer of homodimers.

1917441:SR187 RS07965
gene id: 1917441:SR187_RS07965
uniprot id: A0A2Z5TPV4
names: Similarity
messages: Belongs to the asp23 family.

1917441:SR187 RS03600
gene id: 1917441:SR187_RS03600
uniprot id: A0A2Z5TPM4
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the phosphopentomutase family.
messages: Binds 1 or 2 manganese ions.
messages: Cytoplasm
messages: Phosphotransfer between the C1 and C5 carbon atoms of pentose.

1917441:SR187 RS05985
gene id: 1917441:SR187_RS05985
uniprot id: A0A2Z5TNQ0
names: Similarity
messages: Belongs to the UPF0342 family.

1917441:SR187 RS07625
gene id: 1917441:SR187_RS07625
uniprot id: A0A2Z5TSQ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.
messages: Membrane

1917441:SR187 RS00005
gene id: 1917441:SR187_RS00005
uniprot id: A0A2Z5U1W3
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the DnaA family.
messages: Cytoplasm
messages: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.

1917441:SR187 RS02950
gene id: 1917441:SR187_RS02950
uniprot id: A0A2Z5TLE9
names: Function
names: Similarity
messages: Belongs to the RecR family.
messages: May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.

1917441:SR187 RS05070
gene id: 1917441:SR187_RS05070
uniprot id: A0A2Z5TQH2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.
messages: Cell membrane
messages: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.

1917441:SR187 RS08685
gene id: 1917441:SR187_RS08685
uniprot id: A0A2Z5U5A1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDS family.
messages: Membrane

1917441:SR187 RS07510
gene id: 1917441:SR187_RS07510
uniprot id: A0A2Z5U0H4
names: Function
names: Similarity
messages: Belongs to the aspartate/glutamate racemases family.
messages: Provides the (R)-glutamate required for cell wall biosynthesis.

1917441:SR187 RS05320
gene id: 1917441:SR187_RS05320
uniprot id: A0A2Z5TQM4
names: Similarity
messages: Belongs to the acetyltransferase family.

1917441:SR187 RS04020
gene id: 1917441:SR187_RS04020
uniprot id: A0A2Z5TYT3
names: Caution
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.
messages: Cell membrane
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Membrane

1917441:SR187 RS06150
gene id: 1917441:SR187_RS06150
uniprot id: A0A2Z5TZZ7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-2 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1917441:SR187 RS03300
gene id: 1917441:SR187_RS03300
uniprot id: A0A2Z5TV42
names: Subcellular Location Annotation
messages: Membrane

1917441:SR187 RS06750
gene id: 1917441:SR187_RS06750
uniprot id: A0A2Z5U4E0
names: Similarity
messages: Belongs to the RutC family.

1917441:SR187 RS07870
gene id: 1917441:SR187_RS07870
uniprot id: A0A2Z5TPS7
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the thioester dehydratase family. FabZ subfamily.
messages: Cytoplasm
messages: Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.

1917441:SR187 RS01280
gene id: 1917441:SR187_RS01280
uniprot id: A0A2Z5U297
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.
messages: Cell membrane
messages: Membrane

1917441:SR187 RS07370
gene id: 1917441:SR187_RS07370
uniprot id: A0A2Z5U4U8
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the bacterial CoaD family.
messages: Cytoplasm
messages: Homohexamer.
messages: Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

1917441:SR187 RS04245
gene id: 1917441:SR187_RS04245
uniprot id: A0A2Z5TM97
names: Similarity
messages: Belongs to the EamA transporter family.

1917441:SR187 RS08930
gene id: 1917441:SR187_RS08930
uniprot id: A0A2Z5U5G5
names: Function
names: Similarity
messages: Belongs to the RmuC family.
messages: Involved in DNA recombination.

1917441:SR187 RS00505
gene id: 1917441:SR187_RS00505
uniprot id: A0A2Z5TTI4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL24 family.
messages: One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
messages: One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
messages: Part of the 50S ribosomal subunit.

1917441:SR187 RS04500
gene id: 1917441:SR187_RS04500
uniprot id: A0A2Z5TME1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0073 (Hly-III) family.
messages: Membrane

1917441:SR187 RS00570
gene id: 1917441:SR187_RS00570
uniprot id: A0A2Z5U251
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS13 family.
messages: Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
messages: Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.

1917441:SR187 RS05535
gene id: 1917441:SR187_RS05535
uniprot id: A0A2Z5TN79
names: Similarity
messages: Belongs to the SorC transcriptional regulatory family.

1917441:SR187 RS01895
gene id: 1917441:SR187_RS01895
uniprot id: A0A2Z5U2C7
names: Function
names: Similarity
messages: Belongs to the TrhO family.
messages: Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.

1917441:SR187 RS00985
gene id: 1917441:SR187_RS00985
uniprot id: A0A2Z5TMS7
names: Function
names: Similarity
names: Subunit
messages: A non-essential component of RNA polymerase (RNAP).
messages: Belongs to the RNA polymerase subunit epsilon family.
messages: RNAP is composed of a core of 2 alpha, a beta and a beta' subunit. The core is associated with a delta subunit, and at least one of epsilon or omega. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

1917441:SR187 RS06215
gene id: 1917441:SR187_RS06215
uniprot id: A0A2Z5TRN4
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the MetA family.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.

1917441:SR187 RS09015
gene id: 1917441:SR187_RS09015
uniprot id: A0A2Z5TYR4
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RnpA family.
messages: Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.
messages: RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.

1917441:SR187 RS09550
gene id: 1917441:SR187_RS09550
uniprot id: A0A2Z5TTR3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial solute-binding protein 1 family.
messages: Cell membrane

1917441:SR187 RS04365
gene id: 1917441:SR187_RS04365
uniprot id: A0A2Z5TQA1
names: Similarity
messages: Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.

1917441:SR187 RS02325
gene id: 1917441:SR187_RS02325
uniprot id: A0A2Z5TNM6
names: Similarity
messages: Belongs to the YggT family.

1917441:SR187 RS04105
gene id: 1917441:SR187_RS04105
uniprot id: A0A2Z5TM71
names: Subcellular Location Annotation
messages: Membrane

1917441:SR187 RS04955
gene id: 1917441:SR187_RS04955
uniprot id: A0A2Z5U3N2
names: Function
names: Similarity
messages: Belongs to the UPF0122 family.
messages: Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.

1917441:SR187 RS03470
gene id: 1917441:SR187_RS03470
uniprot id: A0A2Z5TLU0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase alpha/beta chains family.
messages: Cell membrane
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.

1917441:SR187 RS07715
gene id: 1917441:SR187_RS07715
uniprot id: A0A2Z5U4Z2
names: Subcellular Location Annotation
messages: Membrane

1917441:SR187 RS02155
gene id: 1917441:SR187_RS02155
uniprot id: A0A2Z5TKX1
names: Subcellular Location Annotation
messages: Cytoplasm

1917441:SR187 RS03350
gene id: 1917441:SR187_RS03350
uniprot id: A0A2Z5TV50
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the HPr family.
messages: Cytoplasm
messages: General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.
messages: P-Ser-HPr interacts with the catabolite control protein A (CcpA), forming a complex that binds to DNA at the catabolite response elements cre, operator sites preceding a large number of catabolite-regulated genes. Thus, P-Ser-HPr is a corepressor in carbon catabolite repression (CCR), a mechanism that allows bacteria to coordinate and optimize the utilization of available carbon sources. P-Ser-HPr also plays a role in inducer exclusion, in which it probably interacts with several non-PTS permeases and inhibits their transport activity.

1917441:SR187 RS07080
gene id: 1917441:SR187_RS07080
uniprot id: A0A2Z5TXB4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1917441:SR187 RS05645
gene id: 1917441:SR187_RS05645
uniprot id: A0A2Z5TN45
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

1917441:SR187 RS07515
gene id: 1917441:SR187_RS07515
uniprot id: A0A2Z5TXH2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0154 family.
messages: Cell membrane
messages: Membrane

1917441:SR187 RS00535
gene id: 1917441:SR187_RS00535
uniprot id: A0A2Z5TK14
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS5 family.
messages: Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
messages: Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.
messages: The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S4 and S12 plays an important role in translational accuracy.

1917441:SR187 RS00230
gene id: 1917441:SR187_RS00230
uniprot id: A0A2Z5U211
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 2 Mg(2+) ions per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

1917441:SR187 RS05080
gene id: 1917441:SR187_RS05080
uniprot id: A0A2Z5TMW9
names: Function
names: Similarity
names: Subunit
messages: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
messages: Belongs to the ClpX chaperone family.
messages: Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.

1917441:SR187 RS07830
gene id: 1917441:SR187_RS07830
uniprot id: A0A2Z5TQ58
names: Subcellular Location Annotation
messages: Membrane

1917441:SR187 RS08245
gene id: 1917441:SR187_RS08245
uniprot id: A0A2Z5TSP0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1917441:SR187 RS08035
gene id: 1917441:SR187_RS08035
uniprot id: A0A2Z5TPQ3
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bS6 family.
messages: Binds together with bS18 to 16S ribosomal RNA.

1917441:SR187 RS06245
gene id: 1917441:SR187_RS06245
uniprot id: A0A2Z5TNH6
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNase Z family.
messages: Binds 2 Zn(2+) ions.
messages: Homodimer.
messages: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.

1917441:SR187 RS03085
gene id: 1917441:SR187_RS03085
uniprot id: A0A2Z5U2Z5
names: Subcellular Location Annotation
messages: Membrane

1917441:SR187 RS00885
gene id: 1917441:SR187_RS00885
uniprot id: A0A2Z5U269
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the chaperonin (HSP60) family.
messages: Cytoplasm
messages: Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.

1917441:SR187 RS08030
gene id: 1917441:SR187_RS08030
uniprot id: A0A2Z5TQ12
names: Caution
names: Function
names: Subunit
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.

1917441:SR187 RS07825
gene id: 1917441:SR187_RS07825
uniprot id: A0A2Z5TPR1
names: Subcellular Location Annotation
messages: Membrane

1917441:SR187 RS01950
gene id: 1917441:SR187_RS01950
uniprot id: A0A2Z5U2C9
names: Function
names: Similarity
messages: Belongs to the RNase Y family.
messages: Endoribonuclease that initiates mRNA decay.

1917441:SR187 RS02275
gene id: 1917441:SR187_RS02275
uniprot id: A0A2Z5TNL3
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.
messages: Cytoplasm

1917441:SR187 RS07630
gene id: 1917441:SR187_RS07630
uniprot id: A0A2Z5TS70
names: Caution
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1917441:SR187 RS02565
gene id: 1917441:SR187_RS02565
uniprot id: A0A2Z5TXJ5
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.

1917441:SR187 RS07930
gene id: 1917441:SR187_RS07930
uniprot id: A0A2Z5TPY9
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the P-Pant transferase superfamily. AcpS family.
messages: Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.
messages: Cytoplasm
messages: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.

1917441:SR187 RS00800
gene id: 1917441:SR187_RS00800
uniprot id: A0A2Z5TK63
names: Function
messages: Required for transformation and DNA binding.

1917441:SR187 RS06515
gene id: 1917441:SR187_RS06515
uniprot id: A0A2Z5TP36
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.
messages: Part of the 50S ribosomal subunit.

1917441:SR187 RS05195
gene id: 1917441:SR187_RS05195
uniprot id: A0A2Z5TMU2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NnrD/CARKD family.
messages: Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
messages: Homotetramer.

1917441:SR187 RS03030
gene id: 1917441:SR187_RS03030
uniprot id: A0A2Z5TLK0
names: Similarity
messages: Belongs to the UPF0213 family.

1917441:SR187 RS06655
gene id: 1917441:SR187_RS06655
uniprot id: A0A2Z5TRZ0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-DCP.
messages: Belongs to the DltC family.
messages: Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
messages: Cytoplasm

1917441:SR187 RS07345
gene id: 1917441:SR187_RS07345
uniprot id: A0A2Z5U4Y9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the NAD synthetase family.
messages: Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
messages: Homodimer.

1917441:SR187 RS03765
gene id: 1917441:SR187_RS03765
uniprot id: A0A2Z5TYK2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TVP38/TMEM64 family.
messages: Cell membrane
messages: Membrane

1917441:SR187 RS03610
gene id: 1917441:SR187_RS03610
uniprot id: A0A2Z5TLY5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the PNP/MTAP phosphorylase family.
messages: Homotrimer.
messages: The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

1917441:SR187 RS03880
gene id: 1917441:SR187_RS03880
uniprot id: A0A2Z5TVH1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1917441:SR187 RS08315
gene id: 1917441:SR187_RS08315
uniprot id: A0A2Z5U0U8
names: Function
names: Miscellaneous
names: Similarity
names: Subcellular Location Annotation
messages: Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
messages: Belongs to the UppP family.
messages: Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
messages: Cell membrane
messages: Membrane

1917441:SR187 RS03100
gene id: 1917441:SR187_RS03100
uniprot id: A0A2Z5TY06
names: Function
names: Similarity
messages: Belongs to the QueH family.
messages: Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).

1917441:SR187 RS05980
gene id: 1917441:SR187_RS05980
uniprot id: A0A2Z5TNI1
names: Cofactor
names: Similarity
messages: Belongs to the metallo-dependent hydrolases superfamily. NagA family.
messages: Binds 1 divalent metal cation per subunit.

1917441:SR187 RS00555
gene id: 1917441:SR187_RS00555
uniprot id: A0A2Z5TWM9
names: Caution
names: Domain
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the adenylate kinase family.
messages: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
messages: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
messages: Cytoplasm
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Monomer.

1917441:SR187 RS06060
gene id: 1917441:SR187_RS06060
uniprot id: A0A2Z5U411
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL20 family.
messages: Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.

1917441:SR187 RS02395
gene id: 1917441:SR187_RS02395
uniprot id: A0A2Z5U2J5
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the XseB family.
messages: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
messages: Cytoplasm
messages: Heterooligomer composed of large and small subunits.

1917441:SR187 RS08010
gene id: 1917441:SR187_RS08010
uniprot id: A0A2Z5TSH4
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
messages: Membrane

1917441:SR187 RS06570
gene id: 1917441:SR187_RS06570
uniprot id: A0A2Z5TP50
names: Function
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL19 family.
messages: This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.

1917441:SR187 RS00500
gene id: 1917441:SR187_RS00500
uniprot id: A0A2Z5TWL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL14 family.
messages: Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.

1917441:SR187 RS08585
gene id: 1917441:SR187_RS08585
uniprot id: A0A2Z5TYD5
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS15 family.
messages: Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
messages: Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.

1917441:SR187 RS01630
gene id: 1917441:SR187_RS01630
uniprot id: A0A2Z5U2C2
names: Cofactor
messages: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.

1917441:SR187 RS06195
gene id: 1917441:SR187_RS06195
uniprot id: A0A2Z5TNG4
names: Function
names: Similarity
messages: Belongs to the glucose-1-phosphate thymidylyltransferase family.
messages: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.

1917441:SR187 RS06255
gene id: 1917441:SR187_RS06255
uniprot id: A0A2Z5TWT6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.
messages: Cytoplasm
messages: GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
messages: Monomer. Associates with the 50S ribosomal subunit.

1917441:SR187 RS03445
gene id: 1917441:SR187_RS03445
uniprot id: A0A2Z5TPQ2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase A chain family.
messages: Cell membrane
messages: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
messages: Membrane

1917441:SR187 RS01745
gene id: 1917441:SR187_RS01745
uniprot id: A0A2Z5U2C1
names: Function
names: Similarity
names: Subunit
messages: Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
messages: Belongs to the GatC family.
messages: Heterotrimer of A, B and C subunits.

1917441:SR187 RS04130
gene id: 1917441:SR187_RS04130
uniprot id: A0A2Z5TPY0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the transcriptional regulatory Rex family.
messages: Cytoplasm
messages: Homodimer.
messages: Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.

1917441:SR187 RS09660
gene id: 1917441:SR187_RS09660
uniprot id: A0A2Z5TTE2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS4 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.
messages: With S5 and S12 plays an important role in translational accuracy.

1917441:SR187 RS07885
gene id: 1917441:SR187_RS07885
uniprot id: A0A2Z5TPX9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
messages: Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
messages: Homotetramer.

1917441:SR187 RS09670
gene id: 1917441:SR187_RS09670
uniprot id: A0A2Z5TRJ3
names: Function
names: Similarity
messages: Belongs to the helicase family. DnaB subfamily.
messages: Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.

1917441:SR187 RS09030
gene id: 1917441:SR187_RS09030
uniprot id: A0A2Z5TQP0
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1917441:SR187 RS02025
gene id: 1917441:SR187_RS02025
uniprot id: A0A2Z5TNG9
names: Similarity
messages: Belongs to the cysteine synthase/cystathionine beta-synthase family.

1917441:SR187 RS09000
gene id: 1917441:SR187_RS09000
uniprot id: A0A2Z5TQR8
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL34 family.

1917441:SR187 RS06710
gene id: 1917441:SR187_RS06710
uniprot id: A0A2Z5TRI6
names: Similarity
messages: Belongs to the carbamate kinase family.

1917441:SR187 RS00545
gene id: 1917441:SR187_RS00545
uniprot id: A0A2Z5TK02
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL15 family.
messages: Binds to the 23S rRNA.
messages: Part of the 50S ribosomal subunit.

1917441:SR187 RS09325
gene id: 1917441:SR187_RS09325
uniprot id: A0A2Z5TQU7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ABC-3 integral membrane protein family.
messages: Cell membrane
messages: Membrane

1917441:SR187 RS00470
gene id: 1917441:SR187_RS00470
uniprot id: A0A2Z5TMM1
names: Function
names: Similarity
messages: Belongs to the universal ribosomal protein uS19 family.
messages: Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.

1917441:SR187 RS04150
gene id: 1917441:SR187_RS04150
uniprot id: A0A2Z5TM69
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Homohexamer.
messages: Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
messages: Lacks conserved residue(s) required for the propagation of feature annotation.
messages: Part of a set of proteins in which some residues (ACT_SITE, NP_BIND, REGION and BINDING) are not conserved.

1917441:SR187 RS08620
gene id: 1917441:SR187_RS08620
uniprot id: A0A2Z5TQ80
names: Similarity
messages: Belongs to the peptidase M29 family.

1917441:SR187 RS06495
gene id: 1917441:SR187_RS06495
uniprot id: A0A2Z5TWY8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the EzrA family.
messages: Cell membrane
messages: Membrane
messages: Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization.

1917441:SR187 RS01725
gene id: 1917441:SR187_RS01725
uniprot id: A0A2Z5U2C4
names: Similarity
messages: Belongs to the universal stress protein A family.

1917441:SR187 RS02590
gene id: 1917441:SR187_RS02590
uniprot id: A0A2Z5TL97
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
messages: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.
messages: Monomer.
messages: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1917441:SR187 RS03455
gene id: 1917441:SR187_RS03455
uniprot id: A0A2Z5TLS6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ATPase delta chain family.
messages: Cell membrane
messages: F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
messages: This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.

1917441:SR187 RS00540
gene id: 1917441:SR187_RS00540
uniprot id: A0A2Z5U232
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL30 family.
messages: Part of the 50S ribosomal subunit.

1917441:SR187 RS02885
gene id: 1917441:SR187_RS02885
uniprot id: A0A2Z5TP60
names: Function
messages: Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions.

1917441:SR187 RS05665
gene id: 1917441:SR187_RS05665
uniprot id: A0A2Z5U3U7
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

1917441:SR187 RS07600
gene id: 1917441:SR187_RS07600
uniprot id: A0A2Z5TPN4
names: Function
names: Similarity
names: Subunit
messages: Associates with the 50S ribosomal subunit.
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
messages: GTPase that plays an essential role in the late steps of ribosome biogenesis.

1917441:SR187 RS07635
gene id: 1917441:SR187_RS07635
uniprot id: A0A2Z5TPL8
names: Function
names: Similarity
names: Subunit
messages: Belongs to the 6-phosphogluconate dehydrogenase family.
messages: Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
messages: Homodimer.

1917441:SR187 RS06065
gene id: 1917441:SR187_RS06065
uniprot id: A0A2Z5TRJ0
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL35 family.

1917441:SR187 RS09255
gene id: 1917441:SR187_RS09255
uniprot id: A0A2Z5U1I5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1917441:SR187 RS07900
gene id: 1917441:SR187_RS07900
uniprot id: A0A2Z5TXR0
names: Function
names: PTM
names: Similarity
names: Subcellular Location Annotation
messages: 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.
messages: Belongs to the acyl carrier protein (ACP) family.
messages: Carrier of the growing fatty acid chain in fatty acid biosynthesis.
messages: Cytoplasm

1917441:SR187 RS00445
gene id: 1917441:SR187_RS00445
uniprot id: A0A2Z5TJZ0
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS10 family.
messages: Involved in the binding of tRNA to the ribosomes.
messages: Part of the 30S ribosomal subunit.

1917441:SR187 RS02945
gene id: 1917441:SR187_RS02945
uniprot id: A0A2Z5U2W8
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the transpeptidase family.
messages: Cell membrane
messages: Membrane

1917441:SR187 RS01770
gene id: 1917441:SR187_RS01770
uniprot id: A0A2Z5U2C6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.
messages: Cytoplasm

1917441:SR187 RS09270
gene id: 1917441:SR187_RS09270
uniprot id: A0A2Z5TT59
names: Function
names: Subcellular Location Annotation
messages: Membrane
messages: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.

1917441:SR187 RS06985
gene id: 1917441:SR187_RS06985
uniprot id: A0A2Z5TXA3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL1 family.
messages: Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.
messages: Part of the 50S ribosomal subunit.
messages: Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.

1917441:SR187 RS03295
gene id: 1917441:SR187_RS03295
uniprot id: A0A2Z5TY66
names: Subcellular Location Annotation
messages: Membrane

1917441:SR187 RS03740
gene id: 1917441:SR187_RS03740
uniprot id: A0A2Z5TPQ8
names: Caution
names: Function
names: Similarity
names: Subunit
messages: Belongs to the spermidine/spermine synthase family.
messages: Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
messages: Homodimer or homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1917441:SR187 RS04085
gene id: 1917441:SR187_RS04085
uniprot id: A0A2Z5TPX2
names: Function
names: Similarity
messages: Belongs to the cytidine and deoxycytidylate deaminase family.
messages: This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

1917441:SR187 RS00065
gene id: 1917441:SR187_RS00065
uniprot id: A0A2Z5TJR4
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PTH family.
messages: Cytoplasm
messages: Monomer.
messages: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.

1917441:SR187 RS00465
gene id: 1917441:SR187_RS00465
uniprot id: A0A2Z5TMG1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL2 family.
messages: One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
messages: Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.

1917441:SR187 RS05315
gene id: 1917441:SR187_RS05315
uniprot id: A0A2Z5TQX9
names: Similarity
messages: Belongs to the LysR transcriptional regulatory family.

1917441:SR187 RS09070
gene id: 1917441:SR187_RS09070
uniprot id: A0A2Z5U5J7
names: Similarity
messages: Belongs to the beta-class carbonic anhydrase family.

1917441:SR187 RS08240
gene id: 1917441:SR187_RS08240
uniprot id: A0A2Z5U540
names: Similarity
messages: Belongs to the asp23 family.

1917441:SR187 RS06940
gene id: 1917441:SR187_RS06940
uniprot id: A0A2Z5U0C8
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RRF family.
messages: Cytoplasm
messages: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.

1917441:SR187 RS00895
gene id: 1917441:SR187_RS00895
uniprot id: A0A2Z5TMV1
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS7 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
messages: Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.

1917441:SR187 RS07865
gene id: 1917441:SR187_RS07865
uniprot id: A0A2Z5TSC9
names: Function
names: Subunit
messages: Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
messages: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

1917441:SR187 RS00930
gene id: 1917441:SR187_RS00930
uniprot id: A0A2Z5TWT5
names: Similarity
messages: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

1917441:SR187 RS09115
gene id: 1917441:SR187_RS09115
uniprot id: A0A2Z5TYU1
names: Similarity
messages: Belongs to the UDPGP type 2 family.

1917441:SR187 RS00575
gene id: 1917441:SR187_RS00575
uniprot id: A0A2Z5TMI7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS11 family.
messages: Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
messages: Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.

1917441:SR187 RS03870
gene id: 1917441:SR187_RS03870
uniprot id: A0A2Z5TM19
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

1917441:SR187 RS08965
gene id: 1917441:SR187_RS08965
uniprot id: A0A2Z5U191
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
messages: Cytoplasm
messages: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

1917441:SR187 RS08480
gene id: 1917441:SR187_RS08480
uniprot id: A0A2Z5U0Y6
names: Similarity
messages: Belongs to the universal ribosomal protein uS9 family.

1917441:SR187 RS00520
gene id: 1917441:SR187_RS00520
uniprot id: A0A2Z5TMH6
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS8 family.
messages: One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.

1917441:SR187 RS04255
gene id: 1917441:SR187_RS04255
uniprot id: A0A2Z5TVQ7
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

1917441:SR187 RS05230
gene id: 1917441:SR187_RS05230
uniprot id: A0A2Z5TN07
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the GHMP kinase family. Homoserine kinase subfamily.
messages: Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
messages: Cytoplasm

1917441:SR187 RS00785
gene id: 1917441:SR187_RS00785
uniprot id: A0A2Z5U262
names: Similarity
messages: Belongs to the peptidase S66 family.

1917441:SR187 RS06535
gene id: 1917441:SR187_RS06535
uniprot id: A0A2Z5U0A2
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS14 family.
messages: Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
messages: Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.

1917441:SR187 RS04260
gene id: 1917441:SR187_RS04260
uniprot id: A0A2Z5U3D1
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

1917441:SR187 RS05480
gene id: 1917441:SR187_RS05480
uniprot id: A0A2Z5TQR5
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the DapA family.
messages: Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
messages: Cytoplasm
messages: Homotetramer; dimer of dimers.
messages: Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

1917441:SR187 RS06990
gene id: 1917441:SR187_RS06990
uniprot id: A0A2Z5U4L9
names: Function
names: PTM
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL11 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
messages: One or more lysine residues are methylated.
messages: Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.

1917441:SR187 RS09730
gene id: 1917441:SR187_RS09730
uniprot id: A0A2Z5TR74
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.
messages: Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.
messages: Cell membrane
messages: Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).
messages: Membrane

1917441:SR187 RS05020
gene id: 1917441:SR187_RS05020
uniprot id: A0A2Z5TMV5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the YejK family.
messages: nucleoid

1917441:SR187 RS08615
gene id: 1917441:SR187_RS08615
uniprot id: A0A2Z5TQH6
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0410 family.
messages: Membrane

1917441:SR187 RS01910
gene id: 1917441:SR187_RS01910
uniprot id: A0A2Z5TXB6
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecU family.
messages: Binds 1 Mg(2+) ion per subunit.
messages: Cytoplasm
messages: Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation.

1917441:SR187 RS00480
gene id: 1917441:SR187_RS00480
uniprot id: A0A2Z5TK03
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS3 family.
messages: Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
messages: Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.

1917441:SR187 RS08735
gene id: 1917441:SR187_RS08735
uniprot id: A0A2Z5TTB9
names: Similarity
messages: Belongs to the CtsR family.

1917441:SR187 RS07675
gene id: 1917441:SR187_RS07675
uniprot id: A0A2Z5TS82
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the FtsL family.
messages: Cell membrane
messages: Essential cell division protein.
messages: Membrane

1917441:SR187 RS00475
gene id: 1917441:SR187_RS00475
uniprot id: A0A2Z5TK12
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL22 family.
messages: Part of the 50S ribosomal subunit.
messages: The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
messages: This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.

1917441:SR187 RS01385
gene id: 1917441:SR187_RS01385
uniprot id: A0A2Z5TN23
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL33 family.

1917441:SR187 RS07620
gene id: 1917441:SR187_RS07620
uniprot id: A0A2Z5U4X6
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the NrdR family.
messages: Binds 1 zinc ion.
messages: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.

1917441:SR187 RS02465
gene id: 1917441:SR187_RS02465
uniprot id: A0A2Z5TXI2
names: Function
names: Similarity
messages: Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
messages: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.

1917441:SR187 RS04530
gene id: 1917441:SR187_RS04530
uniprot id: A0A2Z5TQ56
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bL12 family.
messages: Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
messages: Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.

1917441:SR187 RS00100
gene id: 1917441:SR187_RS00100
uniprot id: A0A2Z5TJT2
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Cytoplasm
messages: Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.

1917441:SR187 RS00495
gene id: 1917441:SR187_RS00495
uniprot id: A0A2Z5TK00
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS17 family.
messages: One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
messages: Part of the 30S ribosomal subunit.

1917441:SR187 RS04840
gene id: 1917441:SR187_RS04840
uniprot id: A0A2Z5TZC3
names: Cofactor
messages: Binds 1 Mg(2+) ion per trimer.

1917441:SR187 RS00235
gene id: 1917441:SR187_RS00235
uniprot id: A0A2Z5TMA1
names: Similarity
messages: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

1917441:SR187 RS01160
gene id: 1917441:SR187_RS01160
uniprot id: A0A2Z5TKD8
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.
messages: Cytoplasm
messages: Homodimer.

1917441:SR187 RS02870
gene id: 1917441:SR187_RS02870
uniprot id: A0A2Z5TXT3
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the queuine tRNA-ribosyltransferase family.
messages: Binds 1 zinc ion per subunit.
messages: Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
messages: Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.

1917441:SR187 RS08025
gene id: 1917441:SR187_RS08025
uniprot id: A0A2Z5U554
names: Function
names: Similarity
names: Subunit
messages: Belongs to the bacterial ribosomal protein bS18 family.
messages: Binds as a heterodimer with protein bS6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein bS6.

1917441:SR187 RS06220
gene id: 1917441:SR187_RS06220
uniprot id: A0A2Z5TR64
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
messages: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
messages: Cytoplasm
messages: Homodimer.

1917441:SR187 RS02445
gene id: 1917441:SR187_RS02445
uniprot id: A0A2Z5TL79
names: Similarity
messages: Belongs to the acetyltransferase family.

1917441:SR187 RS07530
gene id: 1917441:SR187_RS07530
uniprot id: A0A2Z5TS45
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the BI1 family.
messages: Membrane

1917441:SR187 RS08345
gene id: 1917441:SR187_RS08345
uniprot id: A0A2Z5TQA3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the acetolactate synthase small subunit family.
messages: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.
messages: Dimer of large and small chains.

1917441:SR187 RS07480
gene id: 1917441:SR187_RS07480
uniprot id: A0A2Z5TS29
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ScpB family.
messages: Cytoplasm
messages: Homodimer. Homodimerization may be required to stabilize the binding of ScpA to the Smc head domains. Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.
messages: Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.

1917441:SR187 RS06230
gene id: 1917441:SR187_RS06230
uniprot id: A0A2Z5TNW1
names: Subcellular Location Annotation
messages: Membrane

1917441:SR187 RS00240
gene id: 1917441:SR187_RS00240
uniprot id: A0A2Z5TMG3
names: Function
names: Similarity
messages: Belongs to the RecO family.
messages: Involved in DNA repair and RecF pathway recombination.

1917441:SR187 RS00560
gene id: 1917441:SR187_RS00560
uniprot id: A0A2Z5TTJ0
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the IF-1 family.
messages: Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.
messages: Cytoplasm
messages: One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.

1917441:SR187 RS00460
gene id: 1917441:SR187_RS00460
uniprot id: A0A2Z5U241
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL23 family.
messages: One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
messages: Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.

1917441:SR187 RS01920
gene id: 1917441:SR187_RS01920
uniprot id: A0A2Z5U2D1
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GpsB family.
messages: Cytoplasm
messages: Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation.
messages: Forms polymers through the coiled coil domains. Interacts with PBP1, MreC and EzrA.

1917441:SR187 RS07550
gene id: 1917441:SR187_RS07550
uniprot id: A0A2Z5TPM2
names: Function
names: Similarity
messages: Belongs to the GreA/GreB family.
messages: Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

1917441:SR187 RS08940
gene id: 1917441:SR187_RS08940
uniprot id: A0A2Z5TT12
names: Cofactor
names: Function
names: Similarity
messages: Belongs to the ribulose-phosphate 3-epimerase family.
messages: Binds 1 divalent metal cation per subunit.
messages: Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.

1917441:SR187 RS00490
gene id: 1917441:SR187_RS00490
uniprot id: A0A2Z5TJZ2
names: Similarity
messages: Belongs to the universal ribosomal protein uL29 family.

1917441:SR187 RS01410
gene id: 1917441:SR187_RS01410
uniprot id: A0A2Z5TKJ1
names: Similarity
messages: Belongs to the zinc-containing alcohol dehydrogenase family.

1917441:SR187 RS01440
gene id: 1917441:SR187_RS01440
uniprot id: A0A2Z5TN83
names: Subcellular Location Annotation
messages: Membrane

1917441:SR187 RS00060
gene id: 1917441:SR187_RS00060
uniprot id: A0A2Z5TJR2
names: Function
names: Similarity
messages: ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
messages: Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.

1917441:SR187 RS07970
gene id: 1917441:SR187_RS07970
uniprot id: A0A2Z5TQA4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the elongation factor P family.
messages: Cytoplasm
messages: Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

1917441:SR187 RS03725
gene id: 1917441:SR187_RS03725
uniprot id: A0A2Z5TVD6
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
messages: Cytoplasm
messages: Interacts transiently with the RNA polymerase catalytic core.
messages: Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

1917441:SR187 RS02125
gene id: 1917441:SR187_RS02125
uniprot id: A0A2Z5U2F6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecX family.
messages: Cytoplasm
messages: Modulates RecA activity.

1917441:SR187 RS04270
gene id: 1917441:SR187_RS04270
uniprot id: A0A2Z5TQ14
names: Function
names: PTM
names: Similarity
messages: Belongs to the glycyl radical enzyme (GRE) family. CutC subfamily.
messages: Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde.
messages: Requires the activating protein CutD to generate the key active site glycyl radical on Gly-823 that is involved in catalysis.

1917441:SR187 RS08190
gene id: 1917441:SR187_RS08190
uniprot id: A0A2Z5U536
names: Function
names: Similarity
messages: Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.
messages: Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.

1917441:SR187 RS04035
gene id: 1917441:SR187_RS04035
uniprot id: A0A2Z5TQ26
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the PhoU family.
messages: Cytoplasm
messages: Homodimer.
messages: Plays a role in the regulation of phosphate uptake.

1917441:SR187 RS03135
gene id: 1917441:SR187_RS03135
uniprot id: A0A2Z5TLL1
names: Caution
names: Cofactor
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
messages: Binds 1 pyridoxal phosphate per subunit.
messages: Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
messages: Cytoplasm
messages: Homodimer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1917441:SR187 RS05075
gene id: 1917441:SR187_RS05075
uniprot id: A0A2Z5TMW7
names: Function
names: Similarity
messages: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.
messages: Necessary for normal cell division and for the maintenance of normal septation.

1917441:SR187 RS01635
gene id: 1917441:SR187_RS01635
uniprot id: A0A2Z5TN80
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL28 family.

1917441:SR187 RS00905
gene id: 1917441:SR187_RS00905
uniprot id: A0A2Z5TK83
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
messages: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
messages: Cytoplasm

1917441:SR187 RS09560
gene id: 1917441:SR187_RS09560
uniprot id: A0A2Z5TR07
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the binding-protein-dependent transport system permease family.
messages: Cell membrane
messages: Membrane

1917441:SR187 RS06740
gene id: 1917441:SR187_RS06740
uniprot id: A0A2Z5U0B5
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the gluconeogenesis factor family.
messages: Cytoplasm
messages: Required for morphogenesis under gluconeogenic growth conditions.

1917441:SR187 RS03465
gene id: 1917441:SR187_RS03465
uniprot id: A0A2Z5U330
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the ATPase gamma chain family.
messages: Cell membrane
messages: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.
messages: Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.

1917441:SR187 RS04240
gene id: 1917441:SR187_RS04240
uniprot id: A0A2Z5TM86
names: Similarity
messages: Belongs to the bacterial microcompartments protein family.

1917441:SR187 RS01040
gene id: 1917441:SR187_RS01040
uniprot id: A0A2Z5TKC0
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0324 family.
messages: Cell membrane
messages: Membrane

1917441:SR187 RS00485
gene id: 1917441:SR187_RS00485
uniprot id: A0A2Z5U226
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL16 family.
messages: Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
messages: Part of the 50S ribosomal subunit.

1917441:SR187 RS03290
gene id: 1917441:SR187_RS03290
uniprot id: A0A2Z5TLP5
names: Subcellular Location Annotation
messages: Cytoplasm

1917441:SR187 RS03070
gene id: 1917441:SR187_RS03070
uniprot id: A0A2Z5TPA1
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0298 family.
messages: Cytoplasm

1917441:SR187 RS01390
gene id: 1917441:SR187_RS01390
uniprot id: A0A2Z5TN69
names: Similarity
messages: Belongs to the bacterial ribosomal protein bL32 family.

1917441:SR187 RS08485
gene id: 1917441:SR187_RS08485
uniprot id: A0A2Z5TYA9
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uL13 family.
messages: Part of the 50S ribosomal subunit.
messages: This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.

1917441:SR187 RS06595
gene id: 1917441:SR187_RS06595
uniprot id: A0A1S7IWY6
names: Function
names: Similarity
messages: Belongs to the iron/manganese superoxide dismutase family.
messages: Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1917441:SR187 RS02165
gene id: 1917441:SR187_RS02165
uniprot id: A0A2Z5TXE0
names: Subcellular Location Annotation
messages: Membrane

1917441:SR187 RS02770
gene id: 1917441:SR187_RS02770
uniprot id: A0A2Z5TUR4
names: Cofactor
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the bacterial diacylglycerol kinase family.
messages: Membrane
messages: Mn(2+), Zn(2+), Cd(2+) and Co(2+) support activity to lesser extents.

1917441:SR187 RS00980
gene id: 1917441:SR187_RS00980
uniprot id: A0A2Z5U277
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.
messages: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.
messages: Cytoplasm
messages: Homodimer, may be a subunit of the RNA degradosome.

1917441:SR187 RS02130
gene id: 1917441:SR187_RS02130
uniprot id: A0A2Z5TNH7
names: Similarity
messages: Belongs to the UPF0374 family.

1917441:SR187 RS05290
gene id: 1917441:SR187_RS05290
uniprot id: A0A2Z5TMY4
names: Function
names: Similarity
names: Subunit
messages: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
messages: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.
messages: Homodimer and homohexamer; in equilibrium.
messages: Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.

1917441:SR187 RS07760
gene id: 1917441:SR187_RS07760
uniprot id: A0A2Z5TXL5
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the UPF0291 family.
messages: Cytoplasm

1917441:SR187 RS03845
gene id: 1917441:SR187_RS03845
uniprot id: A0A2Z5TPS4
names: Activity Regulation
names: Caution
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.
messages: Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.
messages: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
messages: Cytoplasm
messages: Homotetramer.
messages: Lacks conserved residue(s) required for the propagation of feature annotation.

1917441:SR187 RS02425
gene id: 1917441:SR187_RS02425
uniprot id: A0A2Z5TNQ4
names: Similarity
messages: Belongs to the bacterial histone-like protein family.

1917441:SR187 RS00415
gene id: 1917441:SR187_RS00415
uniprot id: A0A2Z5TME9
names: Similarity
messages: Belongs to the ArsC family.

1917441:SR187 RS05350
gene id: 1917441:SR187_RS05350
uniprot id: A0A2Z5TZI0
names: Similarity
messages: Belongs to the Nudix hydrolase family.

1917441:SR187 RS04990
gene id: 1917441:SR187_RS04990
uniprot id: A0A2Z5TMP8
names: Subcellular Location Annotation
messages: Membrane

1917441:SR187 RS01205
gene id: 1917441:SR187_RS01205
uniprot id: A0A2Z5TKF2
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the peptidase S26 family.
messages: Cell membrane
messages: Membrane

1917441:SR187 RS01240
gene id: 1917441:SR187_RS01240
uniprot id: A0A2Z5U294
names: Subcellular Location Annotation
messages: Membrane

1917441:SR187 RS00430
gene id: 1917441:SR187_RS00430
uniprot id: A0A2Z5TJZ3
names: Similarity
messages: Belongs to the UPF0473 family.

1917441:SR187 RS01505
gene id: 1917441:SR187_RS01505
uniprot id: A0A2Z5TKL1
names: Function
names: Induction
names: Similarity
messages: Acts as a chaperone.
messages: Belongs to the heat shock protein 70 family.
messages: By stress conditions e.g. heat shock.

1917441:SR187 RS00580
gene id: 1917441:SR187_RS00580
uniprot id: A0A2Z5TMP4
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the RNA polymerase alpha chain family.
messages: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
messages: Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.
messages: The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.

1917441:SR187 RS05970
gene id: 1917441:SR187_RS05970
uniprot id: A0A2Z5TRF8
names: Subcellular Location Annotation
messages: Membrane

1917441:SR187 RS06470
gene id: 1917441:SR187_RS06470
uniprot id: A0A2Z5TNU0
names: Activity Regulation
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the enolase family.
messages: Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
messages: Cell surface
messages: Cytoplasm
messages: Secreted
messages: The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.

1917441:SR187 RS03160
gene id: 1917441:SR187_RS03160
uniprot id: A0A2Z5TPI2
names: Subcellular Location Annotation
messages: Membrane

1917441:SR187 RS08310
gene id: 1917441:SR187_RS08310
uniprot id: A0A2Z5TQ77
names: Domain
names: Function
names: Similarity
names: Subunit
messages: Belongs to the MecA family.
messages: Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.
messages: Homodimer.
messages: The N-terminal domain probably binds unfolded/aggregated proteins; the C-terminal domain interacts with ClpC.

1917441:SR187 RS00890
gene id: 1917441:SR187_RS00890
uniprot id: A0A2Z5TMP7
names: Function
names: Similarity
names: Subunit
messages: Belongs to the universal ribosomal protein uS12 family.
messages: Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
messages: Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.
messages: With S4 and S5 plays an important role in translational accuracy.

1917441:SR187 RS03710
gene id: 1917441:SR187_RS03710
uniprot id: A0A2Z5U354
names: Similarity
names: Subunit
messages: Belongs to the NAD(P)-dependent epimerase/dehydratase family.
messages: Homodimer.

1917441:SR187 RS05430
gene id: 1917441:SR187_RS05430
uniprot id: A0A2Z5TR02
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the UPF0213 family.
messages: Belongs to the UvrC family.
messages: Cytoplasm
messages: Interacts with UvrB in an incision complex.
messages: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.

1917441:SR187 RS06905
gene id: 1917441:SR187_RS06905
uniprot id: A0A2Z5U4J0
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the pyrroline-5-carboxylate reductase family.
messages: Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
messages: Cytoplasm

1917441:SR187 RS04520
gene id: 1917441:SR187_RS04520
uniprot id: A0A2Z5U3F3
names: Function
names: Similarity
names: Subunit
messages: Belongs to the type IA topoisomerase family.
messages: Monomer.
messages: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.

1917441:SR187 RS07430
gene id: 1917441:SR187_RS07430
uniprot id: A0A2Z5TPH3
names: Similarity
messages: Belongs to the UPF0337 (CsbD) family.

1917441:SR187 RS00880
gene id: 1917441:SR187_RS00880
uniprot id: A0A2Z5TTN2
names: Function
names: Similarity
names: Subcellular Location Annotation
names: Subunit
messages: Belongs to the GroES chaperonin family.
messages: Cytoplasm
messages: Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.
messages: Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.

1917441:SR187 RS03080
gene id: 1917441:SR187_RS03080
uniprot id: A0A2Z5TLL2
names: Subcellular Location Annotation
messages: Membrane

1917441:SR187 RS08690
gene id: 1917441:SR187_RS08690
uniprot id: A0A2Z5TTB0
names: Cofactor
names: Function
names: Similarity
names: Subunit
messages: Belongs to the UPP synthase family.
messages: Binds 2 magnesium ions per subunit.
messages: Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
messages: Homodimer.

1917441:SR187 RS02410
gene id: 1917441:SR187_RS02410
uniprot id: A0A2Z5TXH4
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the ArgR family.
messages: Cytoplasm
messages: Regulates arginine biosynthesis genes.

1917441:SR187 RS07095
gene id: 1917441:SR187_RS07095
uniprot id: A0A2Z5TRT5
names: Function
names: Similarity
messages: Belongs to the NanE family.
messages: Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).

1917441:SR187 RS03535
gene id: 1917441:SR187_RS03535
uniprot id: A0A2Z5TV91
names: Similarity
messages: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

1917441:SR187 RS05300
gene id: 1917441:SR187_RS05300
uniprot id: A0A2Z5TZH1
names: Similarity
messages: Belongs to the YjdM family.

1917441:SR187 RS09740
gene id: 1917441:SR187_RS09740
uniprot id: A0A2Z5U1V6
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
messages: Membrane
messages: This protein catalyzes the committed step to the synthesis of the acidic phospholipids.

1917441:SR187 RS00410
gene id: 1917441:SR187_RS00410
uniprot id: A0A2Z5U234
names: Function
names: Similarity
names: Subcellular Location Annotation
messages: Belongs to the RecA family.
messages: Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
messages: Cytoplasm