V-type proton ATPase subunit S1/VOA1 transmembrane
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Phosphatidic acid phosphatase type 2/haloperoxidase
G-protein coupled receptors family 1 profile
G-protein coupled receptors family 3 profile
Dendritic cell-specific transmembrane protein-like
Release factor glutamine methyltransferase N-terminal
Chloride intracellular channel protein 1
Helical; Note=After insertion into the membrane
Required for insertion into the membrane
Gamma-aminobutyric acid receptor subunit alpha-1
Neurotransmitter-gated ion-channel ligand-binding
Neurotransmitter-gated ion-channel transmembrane
Inward rectifier potassium channel C-terminal
Potassium channel inwardly rectifying transmembrane
Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium
Large ribosomal subunit protein uL15/eL18
Exocyst complex component Sec3 PIP2-binding N-terminal
Necessary for localization to the mitochondria
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Large ribosomal subunit protein uL6 N-terminal
Eukaryotic translation initiation factor 4 gamma 2
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Alkylation inactivates the enzyme; essential for the subsequent hydrolysis of the dihydroxyacetone Schiff base
Alters protein-protein interactions, leading to a dimeric protein.
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate
Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate
Schiff-base intermediate with dihydroxyacetone-P
Glycosyltransferase subfamily 4-like N-terminal
Calcium-activated potassium channel subunit beta-1
Ubiquitin-activating enzyme E1 C-terminal
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Aspartate aminotransferase, mitochondrial
N6-(pyridoxal phosphate)lysine; alternate
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
Involved in ceramide and phosphatidylcholine binding
Voltage-dependent anion-selective channel protein 2
Important for enzyme activity, localization to cytoplasmic vesicles, and protein stability
Interchain (between small and large subunit)
Arginine vasopressin-induced protein 1/transcriptional and immune response regulator
Required for phosphatidylinositol 3,4,5-triphosphate binding
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Abolishes cholesterol and 25-hydroxycholesterol binding.
No effect on cholesterol and 25-hydroxycholesterol binding.
Transferrin-like domain-containing protein
AID/alpha-interaction domain; mediates interaction with the beta subunit
Attenuates calcium block of inward barium, lithium, or cadmium currents.
Calcium ion selectivity and permeability
Drastic reduction of barium permeability. Reduction of calcium block of lithium currents.
Important for interaction with STAC1, STAC2 and STAC3
Important for localization in at the junctional membrane
Loss of channel activity and ability to trigger cardiomyocyte contraction; when associated with A-393; A-1145 and A-1446.
Loss of channel activity and ability to trigger cardiomyocyte contraction; when associated with A-393; A-736 and A-1145.
Loss of channel activity and ability to trigger cardiomyocyte contraction; when associated with A-393; A-736 and A-1446.
Loss of channel activity and ability to trigger cardiomyocyte contraction; when associated with A-736; A-1145 and A-1446.
Loss of nifedipine-sensitivity and channel activity; when associated with P-775.
Loss of nifedipine-sensitivity and channel activity; when associated with Y-1066.
Mildly decreased interaction with STAC3.
Moderate reduction of barium permeability. Reduction of calcium block of lithium currents.
Slower channel activation and reduction of current amplitude.
Strongly decreased interaction with STAC3.
Strongly reduced channel clustering at the junctional membrane.
Voltage-dependent L-type calcium channel subunit alpha-1C
Small ribosomal subunit protein uS2 C-terminal
Prokaryotic-type class I peptide chain release factors
DNA-directed RNA polymerase I subunit RPA2
DNA-directed RNA polymerase subunit 2 hybrid-binding
Important for interaction with phosphotyrosine-binding proteins
Peptidyl-prolyl cis-trans isomerase FKBP1B
Cation-transporting P-type ATPase N-terminal
Insulin-like growth factor-binding protein 5
Ionotropic glutamate receptor C-terminal
Ionotropic glutamate receptor L-glutamate and glycine-binding
Formamidopyrimidine-DNA glycosylase catalytic
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2
Bicarbonate transporter-like transmembrane
Janus kinase and microtubule-interacting protein C-terminal
Small ribosomal subunit protein uS17 N-terminal
Does not affect receptor internalization.
Soluble secretory phospholipase A2 receptor
BAAT/Acyl-CoA thioester hydrolase C-terminal
Endoplasmic reticulum vesicle transporter C-terminal
Endoplasmic reticulum vesicle transporter N-terminal
High affinity immunoglobulin epsilon receptor subunit gamma
G-protein coupled receptors family 2 profile 1
G-protein coupled receptors family 2 profile 2
Helical; Signal-anchor for type II membrane protein
Sodium/potassium-transporting ATPase subunit beta-1
Large ribosomal subunit protein uL10-like insertion
GATOR complex protein MIO zinc-ribbon like
Centriolar and ciliogenesis-associated protein HYLS1 C-terminal
Amiloride-sensitive sodium channel subunit beta
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
O-glycosylated at seven sites with GalNAc
Origin recognition complex subunit 5 C-terminal
Translocon-associated protein subunit alpha
Clathrin/coatomer adaptor adaptin-like N-terminal
Coatomer gamma subunit appendage Ig-like subdomain
Serine/threonine-protein phosphatase PP1-beta catalytic subunit
Ciliary BBSome complex subunit 2 C-terminal
Ciliary BBSome complex subunit 2 N-terminal
Ciliary BBSome complex subunit 2 middle region
Sodium/hydrogen exchanger regulatory region
Interaction with phosphoserine on interacting protein
Low-density lipoprotein receptor-related protein
Anaphase-promoting complex subunit 1 C-terminal
Anaphase-promoting complex subunit 1 middle
Major facilitator superfamily (MFS) profile
N-end rule aminoacyl transferase C-terminal
Nearly abolishes its ability to convert adenosine 5'-O-phosphorothioate into 5'-O-monophosphate.
No effect on its ability to convert adenosine 5'-O-phosphorothioate into 5'-O-monophosphate.
Ribonuclease A-domain domain-containing protein
Replication factor-A protein 1 N-terminal
U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein
Pyrroline-5-carboxylate reductase catalytic N-terminal
Cation channel complex component UNC80 N-terminal
Pseudouridine synthase I TruA alpha/beta
Lipid-binding serum glycoprotein N-terminal
Lipid-binding serum glycoprotein N-terminal domain-containing protein
Translation initiation factor eIF-2B subunit delta
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Sodium-dependent multivitamin transporter
Alpha-D-phosphohexomutase alpha/beta/alpha
8 X 2 AA approximate tandem repeats of Q-P
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
Glycosyl transferase family 28 C-terminal
Anaphase-promoting complex subunit 4-like WD40
Translation initiation factor beta propellor-like
NF-kappa-B-activating protein C-terminal
Phosphothreonine; by MTOR, NEK6 and NEK7
Important for selectivity against fructose
Solute carrier family 2, facilitated glucose transporter member 3
Helical; Voltage-sensor; Name=Segment S4
Potassium voltage-gated channel subfamily A member 5
Glucosamine/galactosamine-6-phosphate isomerase
Large ribosomal subunit protein uL23 N-terminal
Essential for stabilizing binding to COTL1
Electron transfer via tryptophanyl radical
Ubiquitin-like modifier-activating enzyme 1
Micro-fibrillar-associated protein 1 C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Jacalin-type lectin domain-containing protein
N6-(2-hydroxyisobutyryl)lysine; alternate
Schiff-base intermediate with substrate; via topaquinone
CSC1/OSCA1-like N-terminal transmembrane
Interaction with galactose moiety of substrate glycoprotein
Aminoacyl-transfer RNA synthetases class-II family profile
ATP-binding cassette sub-family C member 9
Heme-copper oxidase subunit III family profile
Cysteine/serine-rich nuclear protein N-terminal
Endoplasmic reticulum resident protein 29
Endoplasmic reticulum resident protein 29 C-terminal
G protein-regulated inducer of neurite outgrowth C-terminal
Sodium-dependent phosphate transport protein 2A
Interacts with SPRY1, SPRY2, SPRY3 and SPRY4
Helical; Anchor for type IV membrane protein
Abolishes binding to the RFBP isoform of ATP11B.
Required for interaction with the RFBP isoform of ATP11B
Doublesex- and mab-3-related transcription factor C1/C2 C-terminal
Phosphatidylserine amidated glycine; alternate
Nicotinamide phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Binds urokinase plasminogen activator surface receptor
Urokinase-type plasminogen activator chain B
Urokinase-type plasminogen activator long chain A
Urokinase-type plasminogen activator short chain A
ADP-ribosylcysteine; by autocatalysis; in irreversibly inhibited form
Glyceraldehyde-3-phosphate dehydrogenase
S-nitrosocysteine; in reversibly inhibited form
Phosphoserine; by PKC/PRKCG and PKC/PRKCD
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
RNA 3'-terminal phosphate cyclase insert
Confers sensitivity to capsaicin, resiniferatoxin and other vanilloids and confers binding to resiniferatoxin; when associated with M-550. Reduces sensitivity to capsaicin more than 100-fold; when associated with A-514.
Confers sensitivity to capsaicin, resiniferatoxin and other vanilloids and confers binding to resiniferatoxin; when associated with T-553.
Phosphoserine; by PKC/PRKCE and PKC/PRKCZ
Reduces sensitivity to capsaicin more than 100-fold; when associated with T-553.
Required for PIP2-mediated channel inhibition
Transient receptor potential cation channel subfamily V member 1
Translation initiation factor eIF-2B subunit epsilon
Beta-adaptin appendage C-terminal subdomain
Lipid-binding serum glycoprotein C-terminal
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Interaction with STAC, STAC2 and STAC3 (via SH3 domains)
Loss of interaction with STAC2 and STAC3 and strongly decreased channel activity; when associated with 752-AA-753.
Loss of interaction with STAC2 and STAC3 and strongly decreased channel activity; when associated with A-757.
Shifts the threshold potential to more negative values and lowers the concentration threshold for channel activation by caffeine.
Voltage-dependent L-type calcium channel subunit alpha-1S
CCR4-NOT transcription complex subunit 1
CCR4-NOT transcription complex subunit 1 CAF1-binding
CCR4-NOT transcription complex subunit 1 HEAT repeat
CCR4-NOT transcription complex subunit 1 TTP binding
CCR4-Not complex component Not1 C-terminal
May act as a substrate filter by repelling compounds with a negatively charged alpha-carboxylate
T-cell surface glycoprotein CD3 zeta chain
Nuclear export signal; masked by the interaction with BRCA2
Amiloride-sensitive sodium channel subunit gamma
Interchain (with C-60 in C8-gamma chain)
Biopterin-dependent aromatic amino acid hydroxylase family profile
Glycine cleavage T-protein C-terminal barrel
Potassium voltage-gated channel subfamily S member 3
Potassium channel voltage dependent KCNQ C-terminal
Important for the conversion from active R-state to inactive T-state in the presence of AMP
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)
N-acetylmethionine; in peptidyl-prolyl cis-trans isomerase FKBP4; alternate
N-acetylthreonine; in peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; partial
Peptidyl-prolyl cis-trans isomerase FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed
Required for response to bacterial lipopolysaccharide (LPS)
Tumor necrosis factor-inducible gene 6 protein
Important for interaction with CD80 and CD86
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Enhancer of mRNA-decapping protein 4 WD40 repeat region
G-protein coupled receptors family 3 profile domain-containing protein
MHC class I-like antigen recognition-like
Coatomer beta subunit appendage platform
Neuroblastoma-amplified sequence N-terminal
MD-2-related lipid-recognition domain-containing protein
2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)
Thymidylate synthase/dCMP hydroxymethylase
Glycosyl hydrolase family 30 beta sandwich
Dual specificity mitogen-activated protein kinase kinase 1
Voltage-gated potassium channel subunit beta-1
Sodium:neurotransmitter symporter serotonin N-terminal
Parathyroid hormone/parathyroid hormone-related peptide receptor
11-beta-hydroxysteroid dehydrogenase type 2
Histone deacetylase complex subunit SAP30 Sin3 binding
Histone deacetylase complex subunit SAP30 zinc-finger
Ubiquitin carboxyl-terminal hydrolase family 1 cysteine active-site
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Eukaryotic peptide chain release factor subunit 1
NIKS motif; plays an important role in translational termination
Troponin C, slow skeletal and cardiac muscles
Macrophage scavenger receptor types I and II
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
T-cell-specific surface glycoprotein CD28
Nucleotide-binding oligomerization domain-containing protein 2
cGMP-dependent protein kinase interacting
GPI ethanolamine phosphate transferase 1 C-terminal
Methylcytosine dioxygenase TET1-3 oxygenase
Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catalytic activity
Serine/threonine specific protein phosphatases
Required for reduction of TSC22D1 protein stability
Translationally-controlled tumor protein
Growth hormone releasing hormone receptor
Lutropin-choriogonadotropic hormone receptor
Histone-binding protein RBBP4 N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
receptor protein serine/threonine kinase
Ig-like V-type 1; required for binding to polymeric IgA and IgM
N-linked (GlcNAc...) asparagine; in variant N-88
Sodium- and chloride-dependent betaine transporter
A kinase-anchoring proteins AKAP-5 and AKAP-12 calmodulin (CaM)-binding
Di-leucine internalization motif; mediates targeting to late endosome and lysosome membranes
Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport
Mediates proton transfer from the protein to the inner aqueous phase
Major facilitator superfamily associated
Important for FDH activity and activation by fatty acids
Immediate early response 3-interacting protein 1
Helix-hairpin-helix DNA-binding motif class 1
Heterogeneous nuclear ribonucleoprotein C
Potassium channel tetramerisation-type BTB
Abscisic acid G-protein coupled receptor-like
S100/CaBP-9k-type calcium binding subdomain
Electrogenic sodium bicarbonate cotransporter 1
Eukaryotic translation initiation factor 2 subunit 2
Critical for TLR4-TLR6 dimerization and signaling
Low affinity immunoglobulin gamma Fc region receptor III-A
Impairs association with coatomer; when associated with 211-A-A-212.
Impairs association with coatomer; when associated with 215-S-S-216.
Required for TMED10 and TMED2 cis-Golgi network localization
Transmembrane emp24 domain-containing protein 10
2 X 8 AA tandem repeats of G-H-G-H-G-H-S-H
Proliferating cell nuclear antigen PCNA C-terminal
Proliferating cell nuclear antigen PCNA N-terminal
RNA polymerase II-associated protein 1 C-terminal
RNA polymerase II-associated protein 1 N-terminal
Interchain (between beta and alpha chains)
Changes the stereoselectivity of the oxygenation reaction to produce (12S)-HPETE instead of (15S)-HPETE.
Decreases 15 lipoxygenase activity. Exhibits hepoxilin A3 synthase activity.
Polyunsaturated fatty acid lipoxygenase ALOX15
Fanconi Anaemia group E protein C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Odontogenic ameloblast-associated protein
Tumor necrosis factor alpha-induced protein 8-like protein 2
3-beta hydroxysteroid dehydrogenase/isomerase
Ubiquitin-like modifier-activating enzyme Atg7 N-terminal
FACT complex subunit Spt16 N-terminal lobe
Histone chaperone RTT106/FACT complex subunit SPT16-like middle
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Cystic fibrosis transmembrane conductance regulator
Anaphase-promoting complex subunit 4 long
Sodium/potassium-transporting ATPase subunit beta-2
Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
Endothelin-like toxin domain-containing protein
Peptidase M1 membrane alanine aminopeptidase
Microsomal triglyceride transfer protein large subunit
Chemokine interleukin-8-like domain-containing protein
Transmembrane protein 127 transmembrane region
Peptidyl-prolyl cis-trans isomerase FKBP3
CBF1-interacting co-repressor CIR N-terminal
Decreases cell membrane expression. Decreases succinate transport activity.
Decreases cell membrane expression. Decreases succinate transport activity. Decreases Km value for succinate.
Does not affect cell membrane localization. Abolishes succinate transport activity.
Does not affect cell membrane localization. Decreases succinate transport activity.
Does not affect cell membrane localization. Decreases succinate transport activity. Decreases Km value for succinate. More sensitive to inhibition by lithium.
Does not affect cell membrane localization. Decreases succinate transport activity. Insensitive to inhibition by lithium.
Platelet-derived growth factor (PDGF) family profile
Pyrroline-5-carboxylate reductase dimerisation
Co-chaperone HscB C-terminal oligomerisation
Store-operated calcium entry-associated regulatory factor
Serine/arginine repetitive matrix protein C-terminal
Neutral/alkaline non-lysosomal ceramidase C-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
Small ribosomal subunit protein mS23 conserved
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Glutathione S-transferase alpha I, N-terminally processed
N-acetylalanine; in Glutathione S-transferase alpha I, N-terminally processed
Interchain (between alpha-2-1 and delta-1 chains)
Voltage-dependent calcium channel subunit alpha-2-1
Voltage-dependent calcium channel subunit alpha-2/delta-1
Voltage-dependent calcium channel subunit delta-1
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Transcription elongation factor Eaf N-terminal
Essential for DNA hairpin formation, participates in base-stacking interactions near the cleavage site
V(D)J recombination-activating protein 1
Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity
Pre-rRNA-processing protein Ipi1 N-terminal
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4E
Mitochondrial cytochrome c oxidase subunit VIc/VIIs
Disintegrin and metalloproteinase domain-containing protein 2
Spermatid maturation protein 1 N-terminal
Protein phosphatase 1 regulatory subunit 3A
Large ribosomal subunit protein uL2 C-terminal
Exocyst complex subunit Sec15 C-terminal
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Damage-control phosphatase ARMT1-like metal-binding
Phosphatidylcholine-sterol acyltransferase
Calcium-independent phospholipase A2-gamma
Rab geranylgeranyltransferase alpha subunit insert-domain
Telomere-associated protein Rif1 N-terminal
Large neutral amino acids transporter small subunit 2
Vacuolar protein sorting-associated protein 54 C-terminal
Vacuolar protein sorting-associated protein 54 N-terminal
DRY motif; important for ligand-induced conformation changes and signaling
Important for species-specific agonist sensitivity
NPxxY motif; important for ligand-induced conformation changes and signaling
Glycosyl-hydrolase family 116 N-terminal
Glycosyl-hydrolase family 116 catalytic region
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Casein kinase substrate phosphoprotein PP28
ABC-type uncharacterised transport system
Phosphoserine; by CDK5, MAPK14; in vitro
Potassium voltage-gated channel subfamily B member 1
Pericentriolar material 1 protein C-terminal
ATP-grasp fold succinyl-CoA synthetase-type
Peptidase S9 prolyl oligopeptidase catalytic
Cleavage; by caspase-3 or caspase-3-like proteases
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
Trafficking kinesin-binding protein C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
O-linked (Xyl...) (glycosaminoglycan) serine
Large ribosomal subunit protein uL18 C-terminal eukaryotes
Type I cytokine receptor cytokine-binding
Phosphatidylinositol glycan anchor biosynthesis class Y
Retinoblastoma-associated protein C-terminal
Retinoblastoma-associated protein N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Phosphatidylinositol transfer protein alpha isoform
Processed zona pellucida sperm-binding protein 1
In isoform Skeletal 2 and isoform Skeletal 3.
Large ribosomal subunit protein uL6 alpha-beta
Sodium/potassium-transporting ATPase subunit beta-3
Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding
Gamma tubulin complex component C-terminal
Gamma tubulin complex component protein N-terminal
Nucleolus and neural progenitor protein-like N-terminal
Abolished phosphorylation without affecting calmodulin-binding.
Angiotensin-converting enzyme, soluble form
Mimics phosphorylation; does not affect calmodulin-binding.
No effect on activity. 20-fold reduction in catalytic efficiency; when associated with E-727.
No effect on activity. 20-fold reduction in catalytic efficiency; when associated with F-809.
Higher affinity for TEA, lower Vmax and loss of plasma membrane localization.
Higher affinity for TEA. Loss of plasma membrane localization; when associated with Q-76. Loss of plasma membrane localization; when associated with Q-112. Loss of plasma membrane localization; when associated with Q-76 and Q-112.
Involved in recognition of organic cations and participates in structural changes that occur during translocation of organic cations
Important for increased permeability to Na(+) when K(+) levels are subphysiological
Important for intracellular retention in recycling endosomes
Part of a hydrophobic barrier that is stochastically dewetted and limits ion permeability
Loss of self-glucosylation activity and 18 to 30-fold reduction in its ability to trans-glucosylate maltose. Reduces UDP-glucose hydrolytic activity by at least 190-fold.
Loss of self-glucosylation activity and ability to trans-glucosylate maltose. Reduces UDP-glucose hydrolytic activity by at least 190-fold.
Loss of self-glucosylation. No loss of catalytic activity.
Reduced trans-glucosylation activity by at least 260-fold and reduced UDP-glucose hydrolytic activity by 4 to 14-fold.
Somatostatin/Cortistatin C-terminal domain-containing protein
Interleukin-1 receptor antagonist protein
Ubiquitin carboxyl-terminal hydrolase 14
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal
Voltage-dependent L-type calcium channel subunit beta-1
Polyribonucleotide 5'-hydroxyl-kinase Clp1 P-loop
Pre-mRNA cleavage complex subunit Clp1 C-terminal
Receptor-binding cancer antigen expressed on SiSo cells
V(D)J recombination-activating protein 2
MHC class I-like antigen recognition-like domain-containing protein
Dimethylaniline monooxygenase [N-oxide-forming] 2
Increases protein solubility in the absence of detergent.
C4-type zinc-finger of DNA polymerase delta
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Pulmonary surfactant-associated protein B
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Decreases threshold for channel activation by K(+), caffeine and 4-chloro-m-cresol. Decreases inhibition by Mg(2+).
Loss of channel activation by halothane and caffeine due to Ca(2+) store depletion, probably due to constant Ca(2+) leakage through the mutant channel.
Almost complete loss of Ca(2+) transport activity because of reduced Ca(2+) affinity.
Interferes with conformation changes that are essential for ATP-dependent Ca(2+) transport.
No loss of calcium binding. Strongly decreased rate of phosphorylation of the active site Asp residue. Interferes with conformation changes that are essential for ATP-dependent Ca(2+)transport.
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Translin-associated factor X-interacting protein 1 N-terminal
5 X 8 AA tandem repeats of P-H-G-G-G-W-G-Q
YbaK/aminoacyl-tRNA synthetase-associated
TATA box binding protein associated factor (TAF) histone-like fold
O-linked (Xyl...) (chondroitin sulfate) serine
Cytochrome c oxidase subunit 6A1, mitochondrial
Poly (ADP-ribose) glycohydrolase (PARG) catalytic
DRY motif; important for ligand-induced conformation changes
Cerebral cavernous malformations 2 harmonin-homology
Cytoskeleton-associated protein 2 C-terminal
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
Voltage-dependent L-type calcium channel subunit beta-2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
NADH:ubiquinone oxidoreductase 30kDa subunit
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Intron-binding protein aquarius N-terminal
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Critical for specifying symmetric addition of methyl groups
AF1; mediates transcriptional activation
AF2; mediates transcriptional activation
AF3; mediates transcriptional activation
Mediates transcriptional transrepression
Transcription factor CBF/NF-Y/archaeal histone
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
N6,N6-dimethyllysine; by EHMT1 and EHMT2; alternate
Phosphoserine; by CDK5, PRPK, AMPK, NUAK1 and ATM
Serine/threonine-protein phosphatase 4 catalytic subunit
Aspartate 1-(chondroitin 4-sulfate)-ester
Inter-alpha-trypsin inhibitor heavy chain H3
Potassium voltage-gated channel subfamily B member 2
Eukaryotic translation initiation factor 4E
4-carboxyglutamate; in a patient with Moyamoya disease
Essential for determining substrate specificity
Vacuolar protein 14 C-terminal Fig4-binding
Subject to oxidation and hydroselenide loss to dehydroalanine
Kinetochore assembly subunit CENP-C N-terminal
Ankyrin repeat domain-containing protein 1
Bile acid-CoA:amino acid N-acyltransferase
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Serine/threonine-protein kinase receptor
Mitochondrial apoptosis-inducing factor C-terminal
Phosphothreonine; by ROCK2 and PKC/PRKCI
Major intrinsically disordered Notch2-binding receptor 1-like C-terminal
Nuclear speckle splicing regulatory protein 1 N-terminal
Nuclear speckle splicing regulatory protein 1 RS-like
Voltage-gated monoatomic cation channel TMEM109
Protein arginine methyltransferase NDUFAF7
Myosin light chain 1/3, skeletal muscle isoform
6-phosphogluconate dehydrogenase C-terminal
Trafficking protein particle complex subunit 11
Trafficking protein particle complex subunit 11 C-terminal
Golgi associated RAB2 interactor protein-like Rab2B-binding
Transmembrane protein 131-like N-terminal
Transmembrane protein 131-like conserved
DNA-directed RNA polymerase III subunit RPC5 C-terminal
Folate receptor-like domain-containing protein
Ribosomal RNA adenine methylase transferase N-terminal
Choloylglycine hydrolase/NAAA C-terminal
Eukaryotic glycogen debranching enzyme N-terminal
Glycogen debranching enzyme glucanotransferase
Iron/zinc purple acid phosphatase-like C-terminal
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
Interferon-related developmental regulator 2
Sodium/calcium exchanger membrane region
Guanine nucleotide-binding protein subunit beta-5
Central conserved domain (CCD); required for localization to endoplasmic reticulum exit sites
Protein phosphatase 1 regulatory subunit 21 N-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Interchain; with the conotoxin GVIIJ (when the channel is not linked to SCN2B or SCN4B; the bond to SCN2B or SCN4B protects the channel from the inhibition by toxin)
Is directly targeted by the spider protoxin-II
Sodium channel protein type 9 subunit alpha
Voltage-gated Na+ ion channel cytoplasmic
For hydroxyacyl-coenzyme A dehydrogenase activity
Important for hydroxyacyl-coenzyme A dehydrogenase activity
Important for long-chain enoyl-CoA hydratase activity
Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
N-acetylvaline; in Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Mediates interaction with the alpha subunit
Voltage-dependent L-type calcium channel subunit beta-3
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
N-acetyllactosaminide alpha-1,3-galactosyltransferase-like
Alanyl-transfer RNA synthetases family profile
Alpha-N-acetylglucosaminidase C-terminal
Alpha-N-acetylglucosaminidase N-terminal
Alpha-N-acetylglucosaminidase tim-barrel
A-kinase anchor protein 7 RI-RII subunit-binding
Dimethylaniline monooxygenase [N-oxide-forming] 4
Unique cartilage matrix-associated protein
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Important for normal channel activation and inactivation, for interaction with KCNIP2, and probably other family members as well
Interaction with KCNIP1, KCNIP2, and other family members
Potassium voltage-gated channel subfamily D member 2
Decreased affinity for glucose and phlorizin.
Drasticly decreased affinity for glucose and phlorizin.
Involved in sugar-binding/transport and inhibitor binding
Centrosomal protein Cep63/Deup1 N-terminal
Little elongation complex subunit 2 C-terminal
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Nuclear distribution protein nudE-like 1
Required for localization to the centrosome and interaction with dynein, dynactin, tubulin gamma, PCM1 and PCNT
S-palmitoyl cysteine; by ZDHHC2, ZDHHC3 and ZDHHC7
Nuclear condensin complex subunit 3 C-terminal
INO80 complex subunit B-like conserved region
Reduces calcium-sensitivity by over 10000-fold.
Important for binding with the scorpion mesomartoxin; when the scorpion mesomartoxin-rKv1.2/KCNA2 interaction is modeled, this residue is close to the 'Y-57' residue of the toxin
Important for normal, slow channel gating
Potassium voltage-gated channel subfamily A member 2
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
NADH-rubredoxin oxidoreductase C-terminal
Mitochondrial brown fat uncoupling protein 1
Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp
Inositol-tetrakisphosphate 1-kinase N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
non-specific serine/threonine protein kinase
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
Gamma-butyrobetaine hydroxylase-like N-terminal
Histone deacetylase complex subunit SAP130 C-terminal
Calcium/calmodulin-dependent protein kinase type II subunit delta
Pericentrin/AKAP-450 centrosomal targeting
Important for C5-methylcytosine-recognition
Processed zona pellucida sperm-binding protein 4
Solute carrier family 2, facilitated glucose transporter member 1
Peptide methionine sulphoxide reductase MsrA
Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1
Nucleolar pre-ribosomal-associated protein 1 C-terminal
Nucleolar pre-ribosomal-associated protein 1 N-terminal
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-?)
Extracellular superoxide dismutase [Cu-Zn]
Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain
Phosphorylated adapter RNA export protein RNA-binding
5-glutamyl coenzyme A thioester intermediate
Fine-tunes the proton-transfer properties of H-64
Asymmetric dimethylarginine; by CARM1; alternate
Asymmetric dimethylarginine; by PRMT6; alternate
N6-(beta-hydroxybutyryl)lysine; alternate
Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5
Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5
Symmetric dimethylarginine; by PRMT5; alternate
5-glutamyl glycerylphosphorylethanolamine
N6,N6,N6-trimethyllysine; alternate; by EEF1AKMT3
N6,N6-dimethyllysine; alternate; by EEF1AKMT3
N6-methyllysine; alternate; by EEF1AKMT3
Ancestral coatomer element 1 Sec16/Sec31
Glycosyl hydrolase-1 3; Region III. Phlorizin hydrolase/Glycosylceramidase activity
Glycosyl hydrolase-1 4; Region IV. Lactase activity
Nucleophile; for phlorizin hydrolase/Glycosylceramidase activity
Proton donor; for phlorizin hydrolase/Glycosylceramidase activity
Translation elongation factor IF5A C-terminal
Transmembrane protein TMEM132 C-terminal
Transmembrane protein TMEM132 N-terminal
cAMP-dependent protein kinase inhibitor alpha
Spindle assembly abnormal protein 6 N-terminal
Myosin light chain kinase 2, skeletal/cardiac muscle
Beta-hexosaminidase eukaryotic type N-terminal
Ribosomal RNA methyltransferase SPB1-like C-terminal
GDH/6PGL endoplasmic bifunctional protein
Impaired GHR-mediated GH internalization.
Impaired GHR-mediated GH internalization. Greatly reduced ubiquitination.
No effect on GHR-mediated GH internalization.
No effect on GHR-mediated GH internalization. No effect on ubiquitination.
Required for ADAM17-mediated proteolysis
Required for endocytosis and down-regulation
Slightly impaired GHR-mediated GH internalization.
Interchain (between alpha and beta chains)
26S proteasome regulatory subunit RPN2 C-terminal
DXXLL motif involved in the interaction with GGA1
Potential nuclear localization signal for the C-terminal fragment generated by PSEN1
Required for efficient Golgi apparatus - endosome sorting
Required for interaction with GGA1 and GGA2
Cationic amino acid transporter C-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Platelet-activating factor acetylhydrolase
Plasma membrane calcium-transporting ATPase 1
Required for basolateral membrane targeting
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
ER membrane protein complex subunit 7 beta-sandwich
Calcium-activated potassium channel subunit alpha-1
NADH:ubiquinone oxidoreductase chain 4 N-terminal
RNA-polymerase II-associated protein 3-like C-terminal
Helical; Signal-anchor for type III membrane protein
Reduces enzyme activity and alters specificity, so that NADP can be used as cosubstrate.
Glycine cleavage system H protein, mitochondrial
Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil
RNA 2-O ribose methyltransferase substrate binding
'Ionic lock' involved in activated form stabilization
Plays an important role in the conformation switch to the active conformation
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
Aryl hydrocarbon receptor nuclear translocator
Mediates the transcription activity and dimerization of the AHR:ARNT complex
Required for heterodimer formation with EPAS1
Required for heterodimer formation with HIF1A
Corticotropin-releasing factor domain-containing protein
Oxidized low-density lipoprotein receptor 1
Oxidized low-density lipoprotein receptor 1, soluble form
GPI-GlcNAc transferase complex PIG-H component conserved
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
Important for obstruction of the ion pore in the closed conformation
Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform
Phosphorylase b kinase regulatory subunit alpha/beta C-terminal
Carboxylesterase type B domain-containing protein
Alpha-ketoglutarate-dependent dioxygenase FTO catalytic
Failed axon connections homolog N-terminal
SAM-dependent methyltransferase TRM5/TYW2-type
Tumor necrosis factor receptor superfamily member 11B
Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal
Sodium channel modifier 1 acidic C-terminal
Bactericidal permeability-increasing protein
Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal
Nascent polypeptide-associated complex subunit alpha-like UBA
Activator of Hsp90 ATPase AHSA1-like N-terminal
Potassium voltage-gated channel subfamily D member 3
Small ribosomal subunit protein mS35 mitochondrial conserved
Tetratricopeptide repeat protein 7 N-terminal
Calcium-activated potassium channel BK alpha subunit
Integrator complex subunit 14 C-terminal
Integrator complex subunit 14 beta-barrel
Granulocyte-macrophage colony-stimulating factor
Tryptophan synthase beta chain-like PALP
Cilia- and flagella-associated protein 61 N-terminal
Eukaryotic translation initiation factor 2D
C-terminal transmembrane transporter domain
Mitochondrial adenyl nucleotide antiporter SLC25A24
Phosphatidylinositol-specific phospholipase C X
Histone acetyl transferase HAT1 N-terminal
TRF2-interacting telomeric protein/Rap1 C-terminal
Low affinity immunoglobulin gamma Fc region receptor III-B
Short transient receptor potential channel 1
FHF complex subunit HOOK-interacting protein C-terminal
Insulin-like growth factor-binding protein 4
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Ribose-phosphate pyrophosphokinase N-terminal
Gamma-aminobutyric acid receptor-associated protein
Phosphatidylethanolamine amidated glycine; alternate
Potassium-transporting ATPase alpha chain 2
Nucleoporin Nup133/Nup155-like C-terminal
Nucleoporin Nup133/Nup155-like N-terminal
Nearly abolishes inhibition of ATP2A1-mediated calcium uptake.
Reduces inhibition of ATP2A1-mediated calcium uptake.
Slightly reduces inhibition of ATP2A1-mediated calcium uptake.
Drought induced 19 protein type zinc-binding
Phosphorylase b kinase regulatory subunit alpha, liver isoform
Deubiquitinating enzyme MINDY-3/4 conserved
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Growth hormone secretagogue receptor type 1
Gastrin/cholecystokinin peptide hormone domain-containing protein
Required for nuclear speckle localization
Nuclear receptor-binding factor 2 C-terminal
Fibrillar collagen NC1 domain-containing protein
Amiloride-sensitive sodium channel subunit alpha
Involved in ceramide and phosphatidylcholine binding. Critical for channel structural stability and gating
Voltage-dependent anion-selective channel protein 1
Sodium-dependent phosphate transport protein 1
Voltage-dependent calcium channel gamma-1 subunit
Transcription initiation factor IIA gamma subunit C-terminal
Transcription initiation factor IIA gamma subunit N-terminal
Transcription initiation factor TFIID subunit 12
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Ribosomal RNA-processing protein 12-like conserved
RLA class I histocompatibility antigen, alpha chain 11/11
Na(+)/H(+) exchange regulatory cofactor NHE-RF3
Methylmalonic aciduria type A homolog, mitochondrial
Peptidyl-prolyl cis-trans isomerase FKBP1A
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)
Chromatin target of PRMT1 protein C-terminal
Tumor necrosis factor ligand superfamily member 4
WAP four-disulfide core domain protein 2
NADH:ubiquinone oxidoreductase intermediate-associated protein 30
Translation initiation factor eIF-2B subunit beta
U2A'/phosphoprotein 32 family A C-terminal
Sodium/potassium-transporting ATPase subunit alpha-1
7 X 9 AA tandem repeats of Y-P-G-X(3)-P-[GS]-A
Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central
Membrane insertase YidC/Oxa/ALB C-terminal
Blocked amino end (Ser); in form erythrocyte
Corticotropin-releasing factor receptor 1
N-acetyltransferase ESCO acetyl-transferase
Methionyl-tRNA synthetase anticodon-binding
Protein N-terminal glutamine amidohydrolase alpha beta roll
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
Histone deacetylase glutamine rich N-terminal
N-linked (GlcNAc...) (keratan sulfate) asparagine
SAPK-interacting protein 1 Pleckstrin-homology
Interferon-related developmental regulator C-terminal
Interferon-related developmental regulator N-terminal
NAD(P)(+)--arginine ADP-ribosyltransferase
HAUS augmin-like complex subunit 6 N-terminal
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
Nucleolar complex-associated protein 3 N-terminal
Nuclear-interacting partner of ALK/Rsm1-like C-terminal
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
Glycoside hydrolase family 31 N-terminal
Actin, aortic smooth muscle, intermediate form
Hippocampal cholinergic neurostimulating peptide
Phosphatidylethanolamine-binding protein 1
Tumor necrosis factor receptor superfamily member 1A
Essential for binding to NHERF1 PDZ domain
Short transient receptor potential channel 5