Histone RNA hairpin-binding protein RNA-binding
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
Gamma-aminobutyric acid receptor subunit alpha-1
Neurotransmitter-gated ion-channel ligand-binding
Neurotransmitter-gated ion-channel transmembrane
Peptidase metallopeptidase domain-containing protein
N-acetyltransferase ESCO acetyl-transferase
Beta-adaptin appendage C-terminal subdomain
Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain
Olfactomedin-like domain-containing protein
G-protein coupled receptors family 1 profile
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Peroxisome membrane anchor protein Pex14p N-terminal
Alpha galactosidase A C-terminal beta-sandwich
Resistance to inhibitors of cholinesterase protein 3 N-terminal
Resistance to inhibitors of cholinesterase protein 3 N-terminal domain-containing protein
Epididymal secretory glutathione peroxidase
Mothers against decapentaplegic homolog 4
Phosphatidic acid phosphatase type 2/haloperoxidase
Biogenesis of lysosome-related organelles complex 1 subunit 3
Doublesex- and mab-3-related transcription factor 1
G-protein coupled receptors family 2 profile 2
Helical; Signal-anchor for type II membrane protein
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate
Fibrillin unique N-terminal (FUN) domain
Large ribosomal subunit protein uL23 N-terminal
Phosphoserine; by MAPKAPK2, MAPKAPK3 and MAPKAPK5
Major facilitator superfamily (MFS) profile
In SNP-A; possible loss of CK2 phosphorylation site.
In SNP-B; increased semen volume in ejaculate.
Mitochondrial cytochrome c oxidase subunit VIc/VIIs
Rho guanine nucleotide exchange factor 2
Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central
(Microbial infection) Cleavage; by porcine reproductive and respiratory syndrome virus serine protease nsp4
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
Required for interaction with and ubiquitination by MARCHF2
Trafficking protein particle complex subunit 2
Serine/threonine specific protein phosphatases
Actin, cytoplasmic 1, N-terminally processed
N-acetylaspartate; in Actin, cytoplasmic 1, N-terminally processed
Phosphoserine; by MAPK1 and MAPK3; in vitro
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2
in ADMIDAS binding site and liganded-open conformation
in ADMIDAS binding site and unliganded-closed conformation
Small nuclear ribonucleoprotein Prp3 C-terminal
Inward rectifier potassium channel C-terminal
Potassium channel inwardly rectifying transmembrane
Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium
Hyaluronan and proteoglycan link protein 1
Methylcytosine dioxygenase TET1-3 oxygenase
DNA mismatch repair proteins mutS family
N6,N6,N6-trimethyllysine; by METTL21A; alternate
Cholesterol side-chain cleavage enzyme, mitochondrial
Interchain (with C-? in LTBP1 TB3 domain); in inactive form
Results in spontaneous, non integrin-dependent activation.
S-adenosyl-L-homocysteine hydrolase NAD binding
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Large ribosomal subunit protein uL30 N-terminal eukaryotes
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Small ribosomal subunit protein uS17 N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Tryptophan synthase beta chain-like PALP
Transcription factor CBF/NF-Y/archaeal histone
Baculoviral IAP repeat-containing protein 5
S100/CaBP-9k-type calcium binding subdomain
Voltage-dependent anion-selective channel protein 3
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
cAMP-dependent protein kinase inhibitor gamma
Exocyst complex component Sec3 PIP2-binding N-terminal
Interferon-induced GTP-binding protein Mx1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 5
Appears to be essential for biological activity
Nicotinate-nucleotide pyrophosphorylase [carboxylating]
Transcription factor IIIC 90kDa subunit N-terminal
Transcription factor IIIC putative zinc-finger
Interaction with APS and STAT5, and activation
Gamma-interferon-inducible-lysosomal thiol reductase
Glycosyl hydrolase family 30 beta sandwich
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Anaphase-promoting complex subunit 4-like WD40
Cationic amino acid transporter C-terminal
Interacts with SPRY1, SPRY2, SPRY3 and SPRY4
Fibronectin type-III domain-containing protein
Chromosome segregation protein Spc25 C-terminal
Translocon-associated protein subunit beta
MHC class I-like antigen recognition-like
MHC class I-like antigen recognition-like domain-containing protein
Corticotropin-releasing factor-binding protein
5-glutamyl coenzyme A thioester intermediate
Decreases KM for acetoacetate and acetoacetyl-CoA 2-fold. Increases KM for succinate 2-fold. Decreases KM for succinyl-CoA nearly 4-fold. Strongly reduces catalytic activity.
Decreases KM for acetoacetyl-CoA 3-fold. No effect on KM for acetoacetate, succinyl-CoA and succinate.
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial
Succinyl-CoA:3-ketoacid-coenzyme A transferase
G-protein coupled receptors family 2 profile 1
Biogenesis of lysosome-related organelles complex 1 subunit 5
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Interaction with coactivator FXXLF and FXXFY motifs
Interaction with coactivator LXXL and FXXFY motifs
N-linked (GlcNAc...) (complex) asparagine
Sodium/potassium-transporting ATPase subunit alpha-1
Protein phosphatase 1 regulatory subunit 21 N-terminal
contacts bases in the GGAA sequence in the major groove
contacts the phosphate backbone of the GGAA sequence in the minor groove upstream
forms a salt bridge with the phosphate backbone of the opposite strand downstream of the GGAA core sequence
Hydroxymethylglutaryl-CoA synthase, mitochondrial
Secondary ossification center associated regulator of chondrocyte maturation
POU domain, class 5, transcription factor 1
Sodium/calcium exchanger membrane region
Ribosomal RNA adenine methylase transferase N-terminal
Serine/threonine-protein kinase receptor
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein
G-protein coupled receptors family 3 profile
Germ cell-specific gene 1-like protein 2
Galactoside alpha-(1,2)-fucosyltransferase 2
Dolichol-phosphate mannosyltransferase subunit 3
Phosphatidylcholine:ceramide cholinephosphotransferase 1
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Interchain (between light and heavy chains)
Phosphatidylserine amidated glycine; alternate
Mediator of RNA polymerase II transcription subunit 27
Interaction with phosphoserine on interacting protein
Protein N-terminal asparagine amidohydrolase
GATOR complex protein MIO zinc-ribbon like
Retinoblastoma-associated protein C-terminal
Retinoblastoma-associated protein N-terminal
Folate receptor-like domain-containing protein
Cleavage/polyadenylation specificity factor A subunit C-terminal
Cleavage/polyadenylation specificity factor A subunit N-terminal
CCR4-Not complex component Not N-terminal
Important for interaction with G proteins
Parathyroid hormone/parathyroid hormone-related peptide receptor
U2A'/phosphoprotein 32 family A C-terminal
Steroid 17-alpha-hydroxylase/17,20 lyase
6-phosphogluconate dehydrogenase C-terminal
Broad substrate specificity ATP-binding cassette transporter ABCG2
Leucine-rich repeat and fibronectin type-III domain-containing protein 3
Damage-control phosphatase ARMT1-like metal-binding
Micro-fibrillar-associated protein 1 C-terminal
FLYWCH-type zinc finger-containing protein N-terminal
Thiamin pyrophosphokinase thiamin-binding
receptor protein serine/threonine kinase
22 X 6 AA tandem repeats of W-[PQ]-X-P-X-X
Transducer of regulated CREB activity C-terminal
Transducer of regulated CREB activity N-terminal
Transducer of regulated CREB activity middle
Protein-L-isoaspartate(D-aspartate) O-methyltransferase
Neutral/alkaline non-lysosomal ceramidase C-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Adenomatous polyposis coli N-terminal dimerisation
Adenomatous polyposis coli protein basic
T-cell surface glycoprotein CD8 alpha chain
Solute carrier family 52, riboflavin transporter, member 2
Intercellular adhesion molecule N-terminal
Lipid-binding serum glycoprotein N-terminal
Transcription factor TFIIIC triple barrel
Required for plasma membrane localization
Glycine cleavage T-protein C-terminal barrel
Proto-oncogene serine/threonine-protein kinase mos
Phosphomannose isomerase type I C-terminal
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
DNA-directed RNA polymerase RBP11-like dimerisation
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Sulfatase N-terminal domain-containing protein
Cysteine sulfenic acid (-SOH) intermediate
Mitochondrial import receptor subunit TOM7 homolog
Insulin-like growth factor-binding protein 4
Phosphorylase b kinase regulatory subunit alpha/beta C-terminal
53 X approximate heptapeptide repeats (mucin-like domain)
Required for MYLIP-triggered down-regulation of LDLR
Pyrroline-5-carboxylate reductase catalytic N-terminal
Ionotropic glutamate receptor C-terminal
Ionotropic glutamate receptor L-glutamate and glycine-binding
G-protein coupled receptors family 1 profile domain-containing protein
NIF system FeS cluster assembly NifU N-terminal
Nuclear factor of activated T-cells, cytoplasmic 1
N-acetyllactosaminide alpha-1,3-galactosyltransferase
Fibrinogen C-terminal domain-containing protein
5 X 8 AA tandem repeats of P-H-G-G-G-W-G-Q
ABC-type uncharacterised transport system
Important for catalytic activity; essential for amidase activity and zinc hydrate coordination
Histone-binding protein RBBP4 N-terminal
G-protein coupled receptors family 3 profile domain-containing protein
T-cell surface glycoprotein CD3 delta chain
Protein phosphatase 1 regulatory subunit 35 C-terminal
Calcitonin receptor-stimulating peptide 1
Protein-arginine deiminase (PAD) N-terminal
Protein-arginine deiminase (PAD) central
vitamin-K-epoxide reductase (warfarin-sensitive)
Actin, alpha skeletal muscle, intermediate form
AB hydrolase-1 domain-containing protein
Important for agonist activity on V1aR/AVPR1A
Gamma-aminobutyric acid receptor subunit gamma-2
Asymmetric dimethylarginine; by PRMT1; alternate
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate
N6-(2-hydroxyisobutyryl)lysine; alternate
N6-(beta-hydroxybutyryl)lysine; alternate
Omega-N-methylarginine; by PRMT1; alternate
Symmetric dimethylarginine; by PRMT5 and PRMT7; alternate
TATA box binding protein associated factor (TAF) histone-like fold
Aminoacyl-transfer RNA synthetases class-II family profile
Kinetochore assembly subunit CENP-C N-terminal
Interaction with galactose moiety of substrate glycoprotein
Chromatin target of PRMT1 protein C-terminal
Trafficking kinesin-binding protein C-terminal
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
Facilitates cleavage of polynucleotide substrates
Guanine nucleotide-binding protein G(q) subunit alpha
Peptidase S9 prolyl oligopeptidase catalytic
Large ribosomal subunit protein mL46 N-terminal
Interaction with phosphoinositide-3 kinase
Sodium/potassium-transporting ATPase subunit alpha-2
Endoplasmic reticulum vesicle transporter C-terminal
Endoplasmic reticulum vesicle transporter N-terminal
Protein phosphatase 1 regulatory subunit 14B
Critical for TLR4-TLR6 dimerization and signaling
ADP-ribosylcysteine; by autocatalysis; in irreversibly inhibited form
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Glyceraldehyde-3-phosphate dehydrogenase
S-nitrosocysteine; in reversibly inhibited form
Taurochenodeoxycholic 6 alpha-hydroxylase
CBF1-interacting co-repressor CIR N-terminal
Exocyst complex component EXOC2/Sec5 N-terminal
E3 ubiquitin-protein ligase Arkadia N-terminal
S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine
'Ionic lock' involved in activated form stabilization
Causes photoreceptor degeneration beginning during the first weeks after birth.
Plays an important role in the conformation switch to the active conformation
Peroxisome proliferator-activated receptor gamma
Prenylcysteine lyase domain-containing protein
Mediator complex subunit Med25 synapsin 1
Mediator of RNA polymerase II transcription subunit 25 von Willebrand factor type A
Promotes stable association with the 40S ribosome
AP-4 complex subunit epsilon-1 C-terminal
Immunoglobulin subtype domain-containing protein
Golgi associated RAB2 interactor protein-like Rab2B-binding
DNA polymerase alpha/delta/epsilon subunit B
cGMP-dependent protein kinase interacting
Sodium/hydrogen exchanger regulatory region
Processed zona pellucida sperm-binding protein 2
Dolichol-phosphate mannosyltransferase subunit 1
Corticotropin-releasing factor receptor 1
Propionyl-CoA carboxylase beta chain, mitochondrial
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)
Large ribosomal subunit protein uL15/eL18
Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
4 X 5 AA tandem repeats of Q-K-A-[APS]-X
Pre-mRNA processing factor 4 (PRP4)-like
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C
Peroxidase-like; mediates peroxidase activity
Interchain (with C-99 in IL12A and C-76 in IL23A)
Gamma-aminobutyric acid receptor subunit alpha-2
L-type lectin-like domain-containing protein
Translocon-associated protein subunit delta
Formamidopyrimidine-DNA glycosylase catalytic
Transmembrane and immunoglobulin domain containing 3
BPTI/Kunitz inhibitor domain-containing protein
tRNA-splicing endonuclease subunit Sen15
Major seminal plasma glycoprotein PSP-II
FXYD domain-containing ion transport regulator
INO80 complex subunit B-like conserved region
Cysteinyl-selenocysteine (Cys-Sec); redox-active
16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal
RNase L inhibitor RLI-like possible metal-binding
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Serine/threonine-protein phosphatase 1 regulatory subunit 10
NF-kappa-B-activating protein C-terminal
Small ribosomal subunit protein uS15 N-terminal
Amiloride-sensitive amine oxidase [copper-containing]
Schiff-base intermediate with substrate; via topaquinone
Cytochrome c oxidase subunit 7C, mitochondrial
DNA-directed DNA polymerase family A palm
Bactericidal permeability-increasing protein
Lipid-binding serum glycoprotein C-terminal
Receptor-binding cancer antigen expressed on SiSo cells
Aspartate 1-(chondroitin 4-sulfate)-ester
Inter-alpha-trypsin inhibitor heavy chain H1
Rad21/Rec8-like protein C-terminal eukaryotic
Interferon regulatory factor 2-binding protein 1 & 2 zinc finger
Translation elongation factor IF5A C-terminal
O-linked (Xyl...) (glycosaminoglycan) serine
Transforming growth factor beta receptor type 3
FACT complex subunit Spt16 N-terminal lobe
Histone chaperone RTT106/FACT complex subunit SPT16-like middle
Cation-transporting P-type ATPase N-terminal
Platelet-derived growth factor (PDGF) family profile
Probable UDP-sugar transporter protein SLC35A4
Peptidase M1 membrane alanine aminopeptidase
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Proliferating cell nuclear antigen PCNA C-terminal
Proliferating cell nuclear antigen PCNA N-terminal
Lysosome-associated membrane glycoprotein 3
U3 small nucleolar RNA-associated protein 15 C-terminal
Helical; Anchor for type IV membrane protein
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal
Long-chain fatty acid transport protein 1
Translation initiation factor beta propellor-like
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
Cytochrome c oxidase subunit 7A1, mitochondrial
Necessary and sufficient for the diacylglycerol kinase activity
No significant effect on diacylglycerol kinase activity.
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Required and sufficient for targeting to lysosomes and lamellar bodies
Voltage-dependent calcium channel alpha-1 subunit IQ
Coiled-coil domain-containing protein 107
Large ribosomal subunit protein uL2 C-terminal
Reverse transcriptase/retrotransposon-derived protein RNase H-like
Required for homodimer formation and heterodimer formation with ARL6IP1
Targeting to endoplasmic reticulum membrane
ATP synthase F1 complex delta/epsilon subunit N-terminal
Sodium channel modifier 1 acidic C-terminal
Abolishes enzyme activity and stimulation of interferon production; when associated with N-202.
Abolishes enzyme activity and stimulation of interferon production; when associated with Q-200.
Required for activation upon DNA viral infection
Required for association with the cell membrane
Necessary for interaction with APP and inhibitor effects on APP processing
G protein-regulated inducer of neurite outgrowth C-terminal
Required for IL4-induced gene expression
Required for IRS1 activation and IL4-induced cell growth
Signal transducer and activator of transcription 1
Integrin alpha-2 domain-containing protein
Asymmetric dimethylarginine; by CARM1; alternate
KH domain-containing RNA-binding protein QKI
Qua1 domain; involved in homodimerization
Cytoplasmic activation/proliferation-associated protein-1 C term
Glycoside hydrolase family 31 N-terminal
Little elongation complex subunit 2 C-terminal
Mediator of RNA polymerase II transcription subunit 7
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Vasoactive intestinal polypeptide receptor 1
Important for obstruction of the ion pore in the closed conformation
Small ribosomal subunit protein uS4 N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Calcium-activated chloride channel regulator 1
Calcitonin gene-related peptide type 1 receptor
High affinity immunoglobulin epsilon receptor subunit gamma
Beta-hexosaminidase eukaryotic type N-terminal
Important for DNA bending; intercalates between base pairs of target DNA
O-(5'-phospho-DNA)-tyrosine intermediate
DINNN-motif; mediates interaction with SPSB1, SPSB2 and SPSB4
Regulatory solute carrier protein family 1 member 1
Helical; Voltage-sensor; Name=Segment S4
Phosphoserine; by CDK5, MAPK14; in vitro
Potassium voltage-gated channel subfamily B member 1
Interferon-stimulated gene 20 kDa protein
Vitamin K-dependent protein C heavy chain
Vitamin K-dependent protein C light chain
Arginine vasopressin-induced protein 1/transcriptional and immune response regulator
RNA 2-O ribose methyltransferase substrate binding
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Cleavage stimulation factor subunit 1 dimerisation
Required for interaction with prenylated RAB3A and VAMP2
Tissue-type plasminogen activator chain A
Tissue-type plasminogen activator chain B
T-cell surface glycoprotein CD3 epsilon chain
NPxxY; plays a role in stabilizing the activated conformation of the receptor
Pre-rRNA-processing protein Ipi1 N-terminal
5'-AMP-activated protein kinase catalytic subunit alpha-2
Large ribosomal subunit protein uL6 alpha-beta
Important for beta-aspartyl-AMP intermediate formation
Glutathione S-transferase alpha M14, N-terminally processed
N-acetylalanine; in Glutathione S-transferase alpha M14, N-terminally processed
Ubiquitin-like modifier-activating enzyme Atg7 N-terminal
Alpha-ketoglutarate-dependent dioxygenase AlkB-like
Signal transducer and activator of transcription 2
Peptide (Met-Gly) (interchain with G-Cter in ubiquitin)
Membrane-associated progesterone receptor component 1
Phosphoserine; by CDC42BP, CIT, MLCK, PAK1, ROCK1, ROCK2, DAPK1, DAPK2 and ZIPK/DAPK3
Phosphothreonine; by MLCK, CIT and ROCK2
Necessary for interaction with NR6A1 C-terminus
Necessary for interaction with NR6A1 N-terminus
Necessary for transcriptional repression
Switch 2 region; required for interaction with REP1/CHM
Ubiquitin carboxyl-terminal hydrolase family 1 cysteine active-site
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Important for surfactant activity and antibacterial properties
Interchain (between heavy and light chains)
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA
Origin recognition complex subunit 4 C-terminal
Inositol polyphosphate-related phosphatase
High affinity receptor-binding region which is also known as the TP508 peptide
TATA-binding protein interacting (TIP20)
Growth hormone-releasing hormone receptor
Sodium/potassium-transporting ATPase subunit beta-1
Pyrroline-5-carboxylate reductase dimerisation
T-cell surface glycoprotein CD3 gamma chain
Tumor necrosis factor receptor superfamily member 6
Glycerol-3-phosphate acyltransferase 1, mitochondrial
TGF-beta family profile domain-containing protein
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO3)
Transmembrane ascorbate-dependent reductase CYB561
N6,N6-dimethyllysine; by EHMT1 and EHMT2; alternate
Phosphoserine; by CDK5, DYRK2, HIPK2 and PKC/PRKCG
Phosphoserine; by CDK5, PRPK, AMPK, NUAK1 and ATM
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Scavenger receptor cysteine-rich type 1 protein M130
Important for G protein-mediated signaling
Platelet-activating factor acetylhydrolase
Prokaryotic-type class I peptide chain release factors
Granulocyte-macrophage colony-stimulating factor
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
Lysosomal associated membrane protein family member 5
N-acetylalanine; in Protein S100-G, minor isoform
Hyaluronan-mediated motility receptor C-terminal
BAG-similar domain, required and sufficient for interaction with UBL4A
Sufficient for the delivery of client proteins to the endoplasmic reticulum
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Long-chain specific acyl-CoA dehydrogenase, mitochondrial
Platelet-derived growth factor receptor alpha
Histone deacetylase complex subunit SAP30 Sin3 binding
Histone deacetylase complex subunit SAP30 zinc-finger
Processed sterol regulatory element-binding protein 1
Sterol regulatory element-binding protein 1
Pseudouridine synthase I TruA alpha/beta
Phosphoserine; by CHEK1, CHEK2, BRSK1, MAPK14 AND MARK3
Proheparin-binding EGF-like growth factor
Immunoglobulin V-set domain-containing protein
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Retinoic acid receptor responder protein 2
SAM-dependent methyltransferase TRM5/TYW2-type
Nitric oxide synthase-interacting protein zinc-finger
Binds urokinase plasminogen activator surface receptor
Urokinase-type plasminogen activator chain B
Urokinase-type plasminogen activator long chain A
Urokinase-type plasminogen activator short chain A
FXYD domain-containing ion transport regulator 3
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
Chromosome segregation in meiosis protein 3
3-beta hydroxysteroid dehydrogenase/isomerase
Chymotrypsin-like elastase family member 2A
Transcription elongation factor Eaf N-terminal
Nicotinamide phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Basic motif; required for the activation of phospholipid synthesis, but not for CDS1-binding
Phosphoserine; by MAPK1, MAPK3 and RPS6KA3
Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Calcium/calmodulin-dependent protein kinase type II subunit delta
ATP-binding cassette sub-family F member 1
Processed zona pellucida sperm-binding protein 3
Tyrosinase copper-binding domain-containing protein
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Inter-alpha-trypsin inhibitor heavy chain H2
Interferon-related developmental regulator 1
Interferon-related developmental regulator C-terminal
Interferon-related developmental regulator N-terminal
ER membrane protein complex subunit 7 beta-sandwich
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Ectonucleoside triphosphate diphosphohydrolase 5
RNA binding; important for wobble base 34 recognition
Homologous-pairing protein 2 winged helix
Tumor necrosis factor ligand superfamily member 6, membrane form
Tumor necrosis factor ligand superfamily member 6, soluble form
Gly-Pro-Asn (GPN)-loop; involved in dimer interface
Stabilizes the phosphate intermediate; shared with dimeric partner
Clathrin/coatomer adaptor adaptin-like N-terminal
Coatomer gamma subunit appendage Ig-like subdomain
Aspartate aminotransferase, mitochondrial
N6-(pyridoxal phosphate)lysine; alternate
Glucosamine/galactosamine-6-phosphate isomerase
Opioid growth factor receptor (OGFr) conserved
Fat storage-inducing transmembrane protein 1
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
May play an important role for the adaptation of the alcohol substrate into the binding site
May play an important role in catalytic activity
May play an important role in coenzyme binding
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
5'-AMP-activated protein kinase subunit gamma-3
Acid sphingomyelinase-like phosphodiesterase
Sphingomyelin phosphodiesterase C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Myeloid differentiation primary response protein MyD88
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase
Activator of Hsp90 ATPase AHSA1-like N-terminal
Plasma membrane calcium-transporting ATPase 1
Required for basolateral membrane targeting
Tumor necrosis factor receptor superfamily member 5
A-kinase anchor protein 10, mitochondrial
Interchain (between alpha and beta chains)
FAD dependent oxidoreductase domain containing 2
Important for cholesterol binding and cholesterol transfer from NPC1 to liposomes
NPC intracellular cholesterol transporter 1
Modulating (transactivation AF-1); mediates interaction with MACROD1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
DNA endonuclease activator Ctp1 C-terminal
Nucleolar complex-associated protein 3 N-terminal
Hypoxanthine-guanine phosphoribosyltransferase
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
Binds calcium which modulates its enzyme activity
Immediate early response 3-interacting protein 1
O-linked (Xyl...) (chondroitin sulfate) serine
Acyl-CoA-binding domain-containing protein 5
Abolishes phosphorylation and ability to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage.
Translin-associated factor X-interacting protein 1 N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport
Mediates proton transfer from the protein to the inner aqueous phase
Laminin EGF-like domain-containing protein
Potassium channel tetramerisation-type BTB
Choloylglycine hydrolase/NAAA C-terminal
Electron transfer via tryptophanyl radical
BH3-interacting domain death agonist p11
BH3-interacting domain death agonist p13
BH3-interacting domain death agonist p15
V-set and immunoglobulin domain-containing protein 1
Glycosyl transferase CAP10 domain-containing protein
SLA class II histocompatibility antigen, DQ haplotype C beta chain
Torsin-1A-interacting protein 1/2 AAA+ activator
Torsin-1A-interacting protein 1/2 N-terminal
Phospholipase A2 domain-containing protein
Heme-copper oxidase subunit III family profile
Ribose-phosphate pyrophosphokinase N-terminal
DBC1/CARP1 catalytically inactive NUDIX hydrolase
Change in stereoselective activity by the reduction of 3-ketosteroids and benzil into 3beta-hydroxysteroid and R-benzoin, respectively; when associated with F-180.
Change in stereoselective activity by the reduction of 3-ketosteroids and benzil into 3beta-hydroxysteroid and R-benzoin, respectively; when associated with S-177.
Dehydrogenase/reductase SDR family member 4
Important for the maintenance of the quaternary structure, the catalytic activity and cold stability
Responsible for the stereoselective reduction of 3-ketosteroids into 3alpha-hydroxysteroids and benzil into S-benzoin
Copper chaperone for superoxide dismutase
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
MHC class II-associated invariant chain trimerisation
MHC class II-associated invariant chain/CLIP MHC II-interacting
Exocyst complex subunit Exo70 C-terminal
C4-type zinc-finger of DNA polymerase delta
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Coordinates Mg2+ for interaction with Complement factor B Bb fragment
Interchain (between beta and alpha chains)
Isoglutamyl cysteine thioester (Cys-Gln)
Large ribosomal subunit protein uL10-like insertion
18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)
Crumbs cell polarity complex component 2
Lipid-binding serum glycoprotein N-terminal domain-containing protein
Peptidoglycan recognition protein family
Facilitates phospholipid membrane insertion
Phosphotyrosine; by SRC-type Tyr-kinases
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
FHF complex subunit HOOK-interacting protein C-terminal
Involved in recognition of organic cations and participates in structural changes that occur during translocation of organic cations
Lipocalin/cytosolic fatty-acid binding domain-containing protein
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Required for nuclear speckle localization
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Adenylyltransferase and sulfurtransferase MOCS3
Cysteine persulfide intermediate; for sulfurtransferase activity
Glycyl thioester intermediate; for adenylyltransferase activity
Cyclic dinucleotide-binding domain (CBD)
Mediates interaction with ZDHHC1 and ZDHHC11
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
26S proteasome non-ATPase regulatory subunit RPN1 C-terminal
Replication factor-A protein 1 N-terminal
Lymphocyte antigen 6 complex locus protein G5c
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
Rapamycin-insensitive companion of mTOR N-terminal
Rapamycin-insensitive companion of mTOR middle
Methylated-DNA--protein-cysteine methyltransferase
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Sphingolipid delta4-desaturase N-terminal
Signal transducer and activator of transcription 5A
Store-operated calcium entry-associated regulatory factor
Histone acetyl transferase HAT1 N-terminal
Sperm acrosome membrane-associated protein 1
Telomere length regulation protein conserved
Protein phosphatase 1 regulatory subunit 15A/B C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
von Hippel-Lindau disease tumour suppressor alpha
von Hippel-Lindau disease tumour suppressor beta
Cysteine and histidine-rich domain-containing protein 1
Eukaryotic initiation factor 4A-III, N-terminally processed
N-acetylalanine; in Eukaryotic initiation factor 4A-III, N-terminally processed
Lutropin-choriogonadotropic hormone receptor
Beta-1,3-galactosyltransferase 2 N-terminal
BMP and activin membrane-bound inhibitor C-terminal
BMP and activin membrane-bound inhibitor N-terminal
BMP and activin membrane-bound inhibitor homolog
Tumor necrosis factor receptor superfamily member 11B
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
Post-GPI attachment to proteins factor 3
Pyridine nucleotide-disulphide oxidoreductase dimerisation
T-cell-specific surface glycoprotein CD28
Pulmonary surfactant-associated protein D
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
RNA polymerase subunit H/Rpb5 C-terminal
RecQ mediated genome instability protein 1-like N-terminal helical
Processed zona pellucida sperm-binding protein 4
Cell cycle exit and neuronal differentiation protein 1
Geranylgeranyl transferase type-2 subunit alpha
Cocaine- and amphetamine-regulated transcript protein
Spermatogenesis-associated protein 6 N-terminal
Fibrillar collagen NC1 domain-containing protein
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
Ectonucleoside triphosphate diphosphohydrolase 1
Ectonucleoside triphosphate diphosphohydrolase 1 27 kDa subunit
Ectonucleoside triphosphate diphosphohydrolase 1 54 kDa subunit
Required for interaction with SSNA1 and microtubules
Required for interaction with microtubules
Required for interaction with microtubules and microtubule severing
Sufficient for interaction with microtubules
Fetal and adult testis-expressed transcript protein homolog
N5-[4-(S-L-cysteinyl)-5-methyl-1H-imidazol-2-yl]-L-ornithine (Arg-Cys) (interchain with C-151 in KEAP1)
N5-[4-(S-L-cysteinyl)-5-methyl-1H-imidazol-2-yl]-L-ornithine (Cys-Arg) (interchain with R-135 in KEAP1)
S-(2,3-dicarboxypropyl)cysteine; alternate
N-end rule aminoacyl transferase C-terminal
Centrosomal protein Cep63/Deup1 N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Major facilitator superfamily associated
Major facilitator superfamily domain-containing protein 6
Important for AKT1 activation and IL8 production
CSC1/OSCA1-like N-terminal transmembrane
TRF2-interacting telomeric protein/Rap1 C-terminal
Non-structural maintenance of chromosome element 4 C-terminal
26S proteasome regulatory subunit RPN2 C-terminal
May be associated with an increase in number of vertebrae in European domestic breds.
Nuclear receptor subfamily 6 group A member 1
Cysteine/serine-rich nuclear protein N-terminal
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1
Abolished disulfide-linked dimerization. Does not affect dipeptidase activity.
Complete abolition of dipeptidase activity. Does not affect cell membrane localization.
Does not affect dimerization. Does not affect dipeptidase activity.
Cystic fibrosis transmembrane conductance regulator
Casein kinase substrate phosphoprotein PP28
Short-chain specific acyl-CoA dehydrogenase, mitochondrial
Eukaryotic translation initiation factor 1b
In allele MC1R*2 and strain Jeju native black.
In allele MC1R*2 and strain Jeju native black; may form a constitutively active receptor.
Janus kinase and microtubule-interacting protein C-terminal
Essential for determining substrate specificity
Important for interaction with lipoprotein particles
Interaction with ubiquitin. Crossover loop which restricts access of large ubiquitin adducts to the active site
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Guanine nucleotide-binding protein subunit alpha-11
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter C-terminal
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter N-terminal
Has constitutive ATPase activity that decreases in the presence of potassium ions. Has potassium-dependent ATPase activity; when associated with S-804. Has weak potassium-dependent ATPase activity; when associated with G-812.
Has normal potassium-dependent ATPase activity.
Has potassium-dependent ATPase activity; when associated with W-800.
Has potassium-independent constitutive ATPase activity.
Inactive due to impaired folding. Has weak potassium-dependent ATPase activity; when associated with W-800.
Potassium-transporting ATPase alpha chain 1
Reduces potassium-dependent ATPase activity.
Cytoskeleton-associated protein 2 C-terminal
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Sodium/potassium ATPase inhibitor SPAI-2
5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase
L-threonine 3-dehydrogenase, mitochondrial
Odontogenic ameloblast-associated protein
Important for interaction with phosphotyrosine-binding proteins
Mast/stem cell growth factor receptor Kit
Ubiquitin-activating enzyme E1 C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Sterol regulatory element-binding protein cleavage-activating protein
Growth hormone secretagogue receptor type 1
LDL and other lipoprotein receptors binding
Lipid-binding and lipoprotein association
DNA-directed RNA polymerase II subunit RPB9
Trafficking protein particle complex subunit 11
Trafficking protein particle complex subunit 11 C-terminal
UDP-glucuronate decarboxylase N-terminal
Pituitary adenylate cyclase-activating polypeptide 27
Pituitary adenylate cyclase-activating polypeptide 38
Platelet-activating factor acetylhydrolase IB subunit alpha
Required for self-association and interaction with PAFAH1B2 and PAFAH1B3
Cyclic nucleotide phosphodiesterase catalytic
Mitochondrial apoptosis-inducing factor C-terminal
Phosphoserine; by IKKA, IKKB, IKKE and TBK1
Transforming acidic coiled-coil-containing protein C-terminal
Required for reduction of TSC22D1 protein stability
Translationally-controlled tumor protein
BLOC-2 complex member HPS3 central region
Interleukin-13 receptor subunit alpha-1 Ig-like
Type I cytokine receptor cytokine-binding
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2
Abolishes ER localization resulting in plasma membrane localization.
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Enteropeptidase non-catalytic heavy chain
Enteropeptidase non-catalytic mini chain
Protein phosphatase 1 regulatory subunit 15B N-terminal
Antiparallel alpha-helical coiled coil region
NAD(P)(+)--arginine ADP-ribosyltransferase
NKG2-D type II integral membrane protein
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
In strain: Asian domestic pig, Landrace, Chinese Diannan short-ear, Large white 1, Japanese wild boar, P2, Ryukyu wild boar, Satsumae 28, Seishan, Ssc2, AWB10, AWB11, EWB3 and LW1.
In strain: IB9, IB14, IB16, Sardinian wild boar 2 and Ssc3.
In strain: Japanese wild boar 4, Japanese wild boar 11 and AWB10.
Mediator of DNA damage checkpoint protein 1
Required for nuclear localization (NLS1)
Required for nuclear localization (NLS2)
Essential for DNA hairpin formation, participates in base-stacking interactions near the cleavage site
V(D)J recombination-activating protein 1
Nuclear speckle splicing regulatory protein 1 N-terminal
Nuclear speckle splicing regulatory protein 1 RS-like
Multiple myeloma tumor-associated protein 2-like N-terminal
Low molecular weight phosphotyrosine protein phosphatase
Ferritin heavy chain, N-terminally processed
N-acetylthreonine; in Ferritin heavy chain, N-terminally processed
WD repeat-containing protein 18 C-terminal
Nuclear receptor subfamily 0 group B member 1
N6,N6,N6-trimethyllysine; by METTL21A; in vitro
Deubiquitinating enzyme MINDY-3/4 conserved
Has no effect on the forward reaction, but substantially accelerates the reverse reaction of the transport cycle.
Potassium-transporting ATPase subunit beta
Polypeptide N-acetylgalactosaminyltransferase
Pyrrolidone carboxylic acid; in form big gastrin
Pyrrolidone carboxylic acid; in form gastrin
Alters the stereoselectivity of the oxygenation reaction. Changes the stereoselectivity of the oxygenation toward the production of (15S)-HPETE; when associated with I-418.
Alters the stereoselectivity of the oxygenation reaction. Changes the stereoselectivity of the oxygenation toward the production of (15S)-HPETE; when associated with M-419.
Decreased enzymatic activity without effect on iron-binding.
Essential for stabilizing binding to COTL1
Labile enzyme with loss of enzymatic activity.
Labile enzyme with normal enzymatic activity.
Loss of enzymatic activity and iron-binding.
No effect on the stereoselectivity of the oxygenation reaction.
No specific effect on enzymatic activity and iron-binding.
Polyunsaturated fatty acid lipoxygenase ALOX15
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Transitional endoplasmic reticulum ATPase
Bicarbonate transporter-like transmembrane
Translocon-associated protein subunit alpha
Reactive bond for chymotrypsin, trypsin and elastase
von Willebrand factor D and EGF domain-containing protein
Disintegrin and metalloproteinase domain-containing protein 10
U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein
Impaired phosphoenolpyruvate carboxykinase activity, leading to reduced intramuscular fat content, enhanced backfat thickness and lower meat quality.
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Associated with less backfat thickness, slower growth rate and lower feed intake.
Electrogenic sodium bicarbonate cotransporter 1
Troponin C, slow skeletal and cardiac muscles
May play a role in cytoprotective signaling
Membrane-bound segment which detaches upon phosphorylation
Platelet endothelial cell adhesion molecule
Insulin-like growth factor-binding protein 2
Small ribosomal subunit protein uS2 C-terminal
Apoptosis-antagonizing transcription factor C-terminal
N-acetylalanine; in cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed
cAMP-dependent protein kinase type I-alpha regulatory subunit
cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed
tRNA wybutosine-synthesizing protein 3 homolog
Complete loss of viral NS4B ubiquitination; in association with A-64.
Complete loss of viral NS4B ubiquitination; in association with A-67.
Spo11/DNA topoisomerase VI subunit A N-terminal
Cytochrome c oxidase subunit 5B, mitochondrial
NPC intracellular cholesterol transporter 2
Destabilizes the inactive T-state and promotes transition to the R-state.
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Required for phosphatidylinositol 3,4,5-triphosphate binding
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Interaction with coactivator LXXLL motif
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Abolishes additional calmodulin-binding upon unfolding three-helix bundle; when associated with A-851, A-851, A-857 and A-861.
Abolishes additional calmodulin-binding upon unfolding three-helix bundle; when associated with A-851, A-854, A-857 and A-858.
Abolishes additional calmodulin-binding upon unfolding three-helix bundle; when associated with A-851, A-854, A-858 and A-861.
Abolishes additional calmodulin-binding upon unfolding three-helix bundle; when associated with A-851, A-857, A-858 and A-861.
Abolishes additional calmodulin-binding upon unfolding three-helix bundle; when associated with A-854, A-857, A-858 and A-861.
Greatly reduced phosphorylation. Transports uncoated endocytic vesicles to clusters at distinct peripheral sites and alters actin filament structure.
Interaction with TAX1BP1 and CALCOCO2/NDP52
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
Lymphocyte antigen 6 complex locus protein G6d
Soluble interleukin-6 receptor subunit alpha
HAUS augmin-like complex subunit 6 N-terminal
Signal transducer and activator of transcription 5B
Ubiquitin carboxyl-terminal hydrolase isozyme L5
Uso1/p115-like vesicle tethering protein C-terminal
Vesicle tethering protein Uso1/P115-like head
Large ribosomal subunit protein uL18 C-terminal eukaryotes
Voltage-dependent calcium channel gamma-1 subunit
Lysosome-associated membrane glycoprotein 1
N-acetylthreonine; in Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed
Small ribosomal subunit protein RACK1, N-terminally processed
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase
Critical for end-to-end subunit interaction
UTP--glucose-1-phosphate uridylyltransferase
Pituitary-specific positive transcription factor 1
Saposin B-type domain-containing protein
Alpha-2-macroglobulin receptor-associated protein
Disintegrin and metalloproteinase domain-containing protein 17
Interaction with classical swine fever virus envelope glycoprotein E2
Neuron-specific calcium-binding protein hippocalcin
NF-kappa-B essential modulator NEMO CC2-LZ
NF-kappa-B essential modulator NEMO N-terminal
Loss of sialic acid binding. Inhibits PRRSV virus attachment and internalization to alveolar macrophages.
Necessary for PRRSV virus attachment to alveolar macrophage
Potassium channel voltage dependent KCNQ C-terminal
Nucleolus and neural progenitor protein-like N-terminal
Moderately alters interaction with VAV1.
Insulin-like growth factor-binding protein 5
O-linked (GalNAc...) serine; in soluble form
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Phosphorylated adapter RNA export protein RNA-binding
Carnitine O-palmitoyltransferase N-terminal
Endoplasmic reticulum resident protein 29
Endoplasmic reticulum resident protein 29 C-terminal
Gamma-glutamylcyclotransferase AIG2-like
Required for the interaction with KIF5B and for anterograde transport in axons
YENPXY motif; contains endocytosis signal
Fanconi anemia core complex-associated protein 24 pseudonuclease
G protein-activated inward rectifier potassium channel 4
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Membrane insertase YidC/Oxa/ALB C-terminal
Pituitary adenylate cyclase-activating polypeptide type I receptor
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12)
Triggering receptor expressed on myeloid cells 1
Cell division control protein 42 homolog
Telomere-associated protein Rif1 N-terminal
Asymmetric dimethylarginine; by PRMT6; alternate
Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5
Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5
Symmetric dimethylarginine; by PRMT5; alternate
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
Pulmonary surfactant-associated protein A
Phosphatidylinositol 3-kinase catalytic subunit type 3
Dipeptidyl peptidase 4 low complexity region
GPI-GlcNAc transferase complex PIG-H component conserved
Polyribonucleotide 5'-hydroxyl-kinase Clp1 P-loop
Chemokine binding, important for signaling
Important for chemokine binding and signaling
Involved in dimerization; when bound to chemokine
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Ribosomal RNA methyltransferase SPB1-like C-terminal
Nuclear condensin complex subunit 3 C-terminal
Voltage-gated hydrogen channel 1 C-terminal membrane-localisation
Heparinase II N-terminal domain-containing protein
Major intrinsically disordered Notch2-binding receptor 1-like C-terminal
Tetratricopeptide repeat protein 5 OB fold
Glucose-methanol-choline oxidoreductase N-terminal
ATP synthase subunit alpha, mitochondrial
Actin interacting protein 3-like C-terminal
Chemokine interleukin-8-like domain-containing protein
N-acetylvaline; in Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Insulin-like growth factor-binding protein complex acid labile subunit
Involved in ceramide and phosphatidylcholine binding. Critical for channel structural stability and gating
Voltage-dependent anion-selective channel protein 1
Phosphoserine; by DYRK2, NLK, NEK6, IRAK1, RPS6KA5, ZIPK/DAPK3 and PKC/PRKCE
Signal transducer and activator of transcription 3
Signal for sorting from recycling endosomes; interaction with ACAP1
Calcium-activated potassium channel subunit alpha-1
Protein N-terminal glutamine amidohydrolase alpha beta roll
UDP-glucose/GDP-mannose dehydrogenase C-terminal
41 X 9 AA approximate tandem repeats of T-L-S-P-D-L-[GS]-[HQ]-T
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Microsomal triglyceride transfer protein large subunit
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7
Microtubule-associated protein 10 C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
G2 and S phase-expressed protein 1 N-terminal
Important for interaction with target DNA
Saccharopine dehydrogenase-like C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Calcitonin receptor-stimulating peptide 2
RNA 3'-terminal phosphate cyclase insert
Electron transfer flavoprotein subunit beta
N6,N6,N6-trimethyllysine; by ETFBKMT; alternate
DNA polymerase alpha subunit B N-terminal
Protection of telomeres protein 1 ssDNA-binding
Telomeric single stranded DNA binding POT1/Cdc13
Dihydropyrimidine dehydrogenase [NADP(+)]
Loss of enzyme activity. Loss of FAD binding.
Loss of enzyme activity. Reduces iron content.
No effect on enzyme activity. Reduced iron content.
Strongly reduced affinity for uracil. Reduces enzyme activity by 30%.
POU domain, class 2, transcription factor 1
Ankyrin repeat domain-containing protein 1
Tyrosine aminotransferase ubiquitination region
DNA-directed RNA polymerase I subunit RPA2
DNA-directed RNA polymerase subunit 2 hybrid-binding
Multiple inositol polyphosphate phosphatase 1
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Phosphothreonine; by PKB/AKT1 or PKB/AKT2 and SGK1
Integrator complex subunit 14 C-terminal
Integrator complex subunit 14 beta-barrel
Interaction with membrane phospholipid headgroups
Alveolar macrophage chemotactic factor 2
Subject to oxidation and hydroselenide loss to dehydroalanine
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
Mothers against decapentaplegic homolog 3
Phosphothreonine; by CDK2, CDK4 and MAPK
Required for interaction with DNA and JUN and for functional cooperation with JUN
A kinase-anchoring proteins AKAP-5 and AKAP-12 calmodulin (CaM)-binding
Schiff-base intermediate with acetaldehyde
1-acylglycerol-3-phosphate O-acyltransferase ABHD5
PDZ-binding; involved in localization to the apical cell membrane
Stabilizes the active site histidine for nucleophilic attack
Dihydrolipoyl dehydrogenase, mitochondrial
Important for interaction with PDHX and activity of pyruvate dehydrogenase complex
Gamma tubulin complex component C-terminal
Gamma tubulin complex component protein N-terminal
Tumor necrosis factor receptor superfamily member 1A
Calcitonin receptor-stimulating peptide 3
Important for autoinhibition of adenylyltransferase activity
In strain: Large white and Norwegian Landrace.
Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole
N-linked (GlcNAc...) asparagine; partial
Zinc finger Ran-binding domain-containing protein 2
Abolishes calcium-dependent interaction with membranes.
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-?)
Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil
Myosin regulatory light chain 2, atrial isoform
Interaction with beta-gamma G protein dimers
Phosphoinositide 3-kinase regulatory subunit 5
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
Involved in proton transfer during cleavage
DNA replication complex GINS protein SLD5 C-terminal
May act as a substrate filter by repelling compounds with a negatively charged alpha-carboxylate
Iron/zinc purple acid phosphatase-like C-terminal
Phosphoserine; by CaMK2, PKA, PKC and ROCK2
Gamma-butyrobetaine hydroxylase-like N-terminal
Phosphatidylinositol-specific phospholipase C X
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
Cysteine sulfenic acid (-SOH); alternate
Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin); alternate
Required for the recognition of 25-hydroxycholesterol
G-protein coupled receptors family 2 profile 2 domain-containing protein
Insulin-like growth factor-binding protein 1
Voltage-gated Na+ ion channel cytoplasmic
Intercalates between bases and promotes DNA bending
DRY motif; important for ligand-induced conformation changes
Hydrophobic barrier that decreases the speed of ligand binding and dissociation
NPxxY motif; important for ligand-induced conformation changes and signaling
Serine/threonine-protein phosphatase PP1-beta catalytic subunit
Condensin II complex subunit H2 N-terminal
Condensin-2 complex subunit H2 C-terminal
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
Enhancer of mRNA-decapping protein 4 WD40 repeat region
Secretory carrier-associated membrane protein 1
YbaK/aminoacyl-tRNA synthetase-associated
Small conductance calcium-activated potassium channel protein 3
Inter-alpha-trypsin inhibitor heavy chain H4
N-linked (GlcNAc...) (high mannose) asparagine
Elongation factor 1 beta central acidic region eukaryote
Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Superoxide dismutase copper/zinc binding
Nucleoporin Nup133/Nup155-like C-terminal
Cysteine sulfonic acid (-SO3H); alternate
Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
BAAT/Acyl-CoA thioester hydrolase C-terminal
Adhesion molecule immunoglobulin-like domain-containing protein
Leucine rich repeat and fibronectin type III domain containing 2
For hydroxyacyl-coenzyme A dehydrogenase activity
Important for hydroxyacyl-coenzyme A dehydrogenase activity
Important for long-chain enoyl-CoA hydratase activity
Trifunctional enzyme subunit alpha, mitochondrial
Receptor-type tyrosine-protein phosphatase alpha
Involved in ceramide and phosphatidylcholine binding
Voltage-dependent anion-selective channel protein 2
DNA polymerase epsilon subunit B N-terminal
Galactoside alpha-(1,2)-fucosyltransferase 1
cAMP-dependent protein kinase inhibitor alpha
Interaction with ARHGAP33, ANKRA2, CDC42, PRDX3, RAD26L, RBBP6, RPS7 and TRIP4
Biopterin-dependent aromatic amino acid hydroxylase family profile
Interaction with cytokine/interferon/growth hormone receptors
Impairs the hydrolysis rate-lowering effect of taurochenodeoxycholate.
ATP-dependent 6-phosphofructokinase, muscle type
Cerebral cavernous malformations 2 harmonin-homology
Holliday junction recognition protein HJURP central
Holliday junction regulator protein family C-terminal
Deleted in malignant brain tumors 1 protein
Natural resistance-associated macrophage protein 1
Alpha-ketoglutarate-dependent dioxygenase FTO catalytic
BPL/LPL catalytic domain-containing protein
Involved in binding the phosphorylated serine of the phospho-FFAT motif
Vesicle-associated membrane protein-associated protein B
Phospholipid hydroperoxide glutathione peroxidase
Insulin-like growth factor-binding protein 3
T-cell surface glycoprotein CD3 zeta chain
Abolishes phosphorylation (in vitro) and strongly reduces inhibitory activity.
Promotes dephosphorylation of T-38. Abolishes phosphorylation-dependent increase of inhibitory activity.
Protein phosphatase 1 regulatory subunit 14A
Reduces inhibitory activity at least 1000-fold.
60S ribosome subunit biogenesis protein NIP7 homolog
Critical for specifying symmetric addition of methyl groups
Programmed cell death protein 2 C-terminal
Tartrate-resistant acid phosphatase type 5
Immunoglobulin domain-containing protein
Thrombospondin type 1 domain containing 1
Important for interaction with transmembrane receptors
TYRO protein tyrosine kinase-binding protein
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
Calcineurin-binding protein cabin-1 MEF2-binding
Brain and acute leukemia cytoplasmic protein
NADH:ubiquinone oxidoreductase-like 20kDa subunit
4-aminobutyrate aminotransferase, mitochondrial
5'-AMP-activated protein kinase subunit gamma-1
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Pre-mRNA cleavage complex subunit Clp1 C-terminal
Conserved cysteine within steroid binding domain
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)
Loss of phosphorylation and ssociated secretion.
Transcription initiation factor IIA gamma subunit C-terminal
Transcription initiation factor IIA gamma subunit N-terminal
Oxidized low-density lipoprotein receptor 1
Oxidized low-density lipoprotein receptor 1, soluble form
Glutamate dehydrogenase 1, mitochondrial
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
V-type proton ATPase catalytic subunit A
Interleukin-18 receptor accessory protein
Glycine amidinotransferase, mitochondrial
Interaction with TGEV spike glycoprotein
POU domain, class 2, transcription factor 2
TERF1-interacting nuclear factor 2 N-terminal
GDP-fucose protein O-fucosyltransferase 1
WAP four-disulfide core domain protein 2
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Ribosome maturation protein SDO1/SBDS C-terminal
Ribosome maturation protein SDO1/SBDS N-terminal
Ribosome maturation protein SDO1/SBDS central
Necessary for synergistic transcriptional activity with SMAD3