Activator of Hsp90 ATPase AHSA1-like N-terminal
G-protein coupled receptors family 1 profile
Protein phosphatase 1 regulatory subunit 35 C-terminal
Neuroblastoma-amplified sequence N-terminal
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate
SUMO-activating enzyme subunit 2 C-terminal
Ubiquitin/SUMO-activating enzyme ubiquitin-like
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate
S100/CaBP-9k-type calcium binding subdomain
Zinc finger and BTB domain-containing protein 22
Guanine nucleotide-binding protein G(s) subunit alpha
Transcription factor CBF/NF-Y/archaeal histone
Insulin-like growth factor-binding protein 4
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Phosphatidylserine amidated glycine; alternate
Biopterin-dependent aromatic amino acid hydroxylase family profile
Telomeric single stranded DNA binding POT1/Cdc13
Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
BAAT/Acyl-CoA thioester hydrolase C-terminal
Helical; Voltage-sensor; Name=S4 of repeat I
Helical; Voltage-sensor; Name=S4 of repeat II
Helical; Voltage-sensor; Name=S4 of repeat III
Helical; Voltage-sensor; Name=S4 of repeat IV
Sodium channel protein type 10 subunit alpha
Major facilitator superfamily (MFS) profile
Lipid-binding serum glycoprotein N-terminal
Large ribosomal subunit protein uL4 C-terminal
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
In a bob-tailed dog; alters the ability of the protein to bind to its consensus DNA target.
Serine/threonine specific protein phosphatases
Nascent polypeptide-associated complex subunit alpha-like UBA
Important for cleavage of target proteins
Vacuolar protein 14 C-terminal Fig4-binding
A kinase-anchoring proteins AKAP-5 and AKAP-12 calmodulin (CaM)-binding
Chemokine interleukin-8-like domain-containing protein
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
Interacts with target acceptor peptide in protein substrate
N-linked (GlcNAc...) (high mannose) asparagine
Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal
CSC1/OSCA1-like N-terminal transmembrane
Natural resistance-associated macrophage protein 1
Aminoacyl-transfer RNA synthetases class-II family profile
Beta-adaptin appendage C-terminal subdomain
Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain
Found in dogs with neurodegenerative disease.
Required for interaction with RPP20/POP7
DET1- and DDB1-associated protein 1 N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Alpha-ketoglutarate-dependent dioxygenase AlkB-like
Peroxisome proliferator-activated receptor gamma
Platelet-derived growth factor receptor-like protein
Tartrate-resistant acid phosphatase type 5
Critical for TLR4-TLR6 dimerization and signaling
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Helical; Signal-anchor for type II membrane protein
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2
Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central
ER membrane protein complex subunit 7 beta-sandwich
Ionotropic glutamate receptor C-terminal
Ionotropic glutamate receptor L-glutamate and glycine-binding
Neurotransmitter-gated ion-channel ligand-binding
Neurotransmitter-gated ion-channel transmembrane
Dominant negative mutant that impairs vesicular protein transport.
Lymphocyte antigen 6 complex locus protein G5c
Processed zona pellucida sperm-binding protein 3
Transcriptional coactivator p15 (PC4) C-terminal
Potassium-transporting ATPase alpha chain 1
Ubiquitin carboxyl-terminal hydrolase family 1 cysteine active-site
G-protein coupled receptors family 2 profile 2
Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity
Transmembrane protein 127 transmembrane region
MHC class II-associated invariant chain trimerisation
MHC class II-associated invariant chain/CLIP MHC II-interacting
Interleukin-13 receptor subunit alpha-1 Ig-like
Type I cytokine receptor cytokine-binding
Tetratricopeptide repeat protein 5 OB fold
Cation-transporting P-type ATPase N-terminal
Vesicular integral-membrane protein VIP36
Soluble Vascular Cell Adhesion Molecule-1
Abnormal spindle-like microcephaly-associated protein homolog
Dihydrolipoyl dehydrogenase, mitochondrial
Important for interaction with PDHX and activity of pyruvate dehydrogenase complex
Translocating chain-associated membrane protein 1
Pyrroline-5-carboxylate reductase catalytic N-terminal
Ribitol-5-phosphate transferase FKTN N-terminal
Interaction with phosphoserine on interacting protein
Essential for stabilizing binding to COTL1
Ceroid-lipofuscinosis neuronal protein 5
Ceroid-lipofuscinosis neuronal protein 5, secreted form
Protein transport protein Sec61 subunit alpha isoform 1
Interchain (between light and heavy chains)
Vitamin K-dependent protein C heavy chain
Vitamin K-dependent protein C light chain
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Helical; Voltage-sensor; Name=Segment S4
Important for binding with the scorpion mesomartoxin; when the scorpion mesomartoxin-rKv1.2/KCNA2 interaction is modeled, this residue is close to the 'Y-57' residue of the toxin
Important for normal, slow channel gating
Potassium voltage-gated channel subfamily A member 2
NF-kappa-B-activating protein C-terminal
Trafficking protein particle complex subunit 11
Trafficking protein particle complex subunit 11 C-terminal
Tyrosine aminotransferase ubiquitination region
Large ribosomal subunit protein uL10-like insertion
Rad21/Rec8-like protein C-terminal eukaryotic
Neuronal acetylcholine receptor subunit alpha-7
Multidrug resistance-associated protein 1
Corticotropin-releasing factor-binding protein
TYRO protein tyrosine kinase-binding protein
Trafficking kinesin-binding protein C-terminal
Essential for protaglandin-E synthase activity
RNA binding; important for wobble base 34 recognition
Helix-hairpin-helix DNA-binding motif class 1
Nerve growth factor-related domain-containing protein
S-adenosyl-L-homocysteine hydrolase NAD binding
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Ribose-phosphate pyrophosphokinase N-terminal
Nucleoporin Nup133/Nup155-like C-terminal
U2A'/phosphoprotein 32 family A C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter C-terminal
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
RNA polymerase II assembly factor Rtp1 C-terminal
Transcription initiation factor TFIID subunit 12
In MCR; profound effect on the voltage-dependence of activation such that mutant channels have a greatly reduced open probability at voltages near the resting membrane potential of skeletal muscle.
G-protein coupled receptors family 3 profile
Calcitonin receptor-stimulating peptide 2
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Voltage-gated Na+ ion channel cytoplasmic
Coiled-coil domain-containing protein 66
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Helical; Anchor for type IV membrane protein
Sodium- and chloride-dependent betaine transporter
Condensin II complex subunit H2 N-terminal
Condensin-2 complex subunit H2 C-terminal
Anaphase-promoting complex subunit 4-like WD40
MHC class I-like antigen recognition-like
Low-density lipoprotein receptor-related protein
Helical; Signal-anchor for type III membrane protein
Receptor-binding cancer antigen expressed on SiSo cells
B-cell antigen receptor complex-associated protein alpha chain
Phosphotyrosine; by SRC-type Tyr-kinases
Transmembrane emp24 domain-containing protein 11
Inward rectifier potassium channel C-terminal
Potassium channel inwardly rectifying Kir N-terminal
Potassium channel inwardly rectifying transmembrane
Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium
Guanine nucleotide-binding protein G(t) subunit alpha-1
Bactericidal permeability-increasing protein
Lipid-binding serum glycoprotein C-terminal
RNA-polymerase II-associated protein 3-like C-terminal
Calcium-activated potassium channel BK alpha subunit
Prokaryotic-type class I peptide chain release factors
Glycosyl hydrolase family 30 beta sandwich
Insulin-like growth factor-binding protein 5
Interleukin-1 receptor antagonist protein
Serine/threonine-protein kinase receptor
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
Major facilitator superfamily associated
Lens epithelium-derived growth factor integrase-binding
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Dynein regulatory complex protein 1 C-terminal
Dynein regulatory complex protein 1/2 N-terminal
O-linked (GalNAc...) threonine; alternate
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Peptidase M1 membrane alanine aminopeptidase
Methylated-DNA--protein-cysteine methyltransferase
Sufficient to mediate interaction with SGIP1
cGMP-dependent protein kinase interacting
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
CBF1-interacting co-repressor CIR N-terminal
Polyribonucleotide 5'-hydroxyl-kinase Clp1 P-loop
Pre-mRNA cleavage complex subunit Clp1 C-terminal
Transcription factor TFIIIC triple barrel
Cytoskeleton-associated protein 2 C-terminal
Carnitine O-palmitoyltransferase N-terminal
Cleavage (when cotranslationally processed)
S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine; alternate
Hippocampal cholinergic neurostimulating peptide
Phosphatidylethanolamine-binding protein 1
Micro-fibrillar-associated protein 1 C-terminal
Sodium/calcium exchanger membrane region
Origin recognition complex subunit 5 C-terminal
Impairs normal protein trafficking through early endosomes.
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal
RNase L inhibitor RLI-like possible metal-binding
Endoplasmic reticulum vesicle transporter C-terminal
Endoplasmic reticulum vesicle transporter N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Peptide methionine sulphoxide reductase MsrA
DLA class II histocompatibility antigen, DR-1 beta chain
Required for binding alpha, beta and gamma catenins
Translocon-associated protein subunit alpha
Large ribosomal subunit protein uL2 C-terminal
Beta-hexosaminidase eukaryotic type N-terminal
SNARE-complex protein Syntaxin-18 N-terminal
N-acetyltransferase ESCO acetyl-transferase
Small ribosomal subunit protein uS4 N-terminal
Protein transport protein Sec61 subunit beta
Important for interaction with phosphotyrosine-binding proteins
Mast/stem cell growth factor receptor Kit
Phosphorylase b kinase regulatory subunit alpha/beta C-terminal
Ancestral coatomer element 1 Sec16/Sec31
NADH:ubiquinone oxidoreductase intermediate-associated protein 30
GPI ethanolamine phosphate transferase 1 C-terminal
Corticotropin-releasing factor receptor 1
G-protein coupled receptors family 2 profile 1
Large ribosomal subunit protein uL15/eL18
Dolichol-phosphate mannosyltransferase subunit 3
Glycosyltransferase subfamily 4-like N-terminal
DRY motif; important for ligand-induced conformation changes
NPxxY motif; important for ligand-induced conformation changes and signaling
Fanconi anemia core complex-associated protein 24 pseudonuclease
Post-GPI attachment to proteins factor 3
Release factor glutamine methyltransferase N-terminal
Vacuolar protein sorting-associated protein 13 DH-like
Vacuolar protein sorting-associated protein 13 VPS13 adaptor binding
Vacuolar protein sorting-associated protein 13 extended chorein
Anaphase-promoting complex subunit 1 C-terminal
Anaphase-promoting complex subunit 1 middle
Transforming acidic coiled-coil-containing protein C-terminal
Rab geranylgeranyltransferase alpha subunit insert-domain
Actin, cytoplasmic 1, N-terminally processed
N-acetylaspartate; in Actin, cytoplasmic 1, N-terminally processed
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Ribosomal RNA-processing protein 12-like conserved
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Chromatin target of PRMT1 protein C-terminal
Abolishes GlcCer binding. No effect on membrane tubulation.
Glycolipid transfer protein homology domain
No binding of PtdIns4P. Very little induction of membrane tubulation.
Pleckstrin homology domain-containing family A member 8
Translocon-associated protein subunit beta
Protein-arginine deiminase (PAD) N-terminal
Protein-arginine deiminase (PAD) central
Asymmetric dimethylarginine; by PRMT6; alternate
Omega-N-methylarginine; by PRMT6; alternate
Vacuolar protein sorting-associated protein 54 N-terminal
PiggyBac transposable element-derived protein
LKB1 serine/threonine kinase interacting protein 1 N-terminal
Gamma-glutamylcyclotransferase AIG2-like
T-cell surface glycoprotein CD3 epsilon chain
Cleavage/polyadenylation specificity factor A subunit C-terminal
Cleavage/polyadenylation specificity factor A subunit N-terminal
Acylamino-acid-releasing enzyme N-terminal
Important for degradation of atrial natriuretic peptide by IDE
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
Methionyl-tRNA synthetase anticodon-binding
Inactive pancreatic lipase-related protein 1
Removes steric hindrance and restores lipase activity; when associated with A-196.
Removes steric hindrance and restores lipase activity; when associated with P-198.
Histone acetyl transferase HAT1 N-terminal
Fms related receptor tyrosine kinase 3 ligand
O-linked (GalNAc...) serine; in soluble form
O-linked (Gal...) hydroxylysine; alternate
Beta-1,3-galactosyltransferase 2 N-terminal
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Cationic amino acid transporter C-terminal
GATOR complex protein MIO zinc-ribbon like
tRNA (32-2'-O)-methyltransferase regulator THADA
Signal recognition particle 14 kDa protein
'Ionic lock' involved in activated form stabilization
Plays an important role in the conformation switch to the active conformation
O-linked (Xyl...) (glycosaminoglycan) serine
In narcolepsy; autosomal recessive; loss of function.
Electron transfer via tryptophanyl radical
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
cAMP-dependent protein kinase catalytic subunit alpha
Promotes stable association with the 40S ribosome
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Cysteine/serine-rich nuclear protein N-terminal
Pre-mRNA processing factor 4 (PRP4)-like
Small ribosomal subunit protein mS23 conserved
Tumor necrosis factor receptor superfamily member 6
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members
Casein kinase substrate phosphoprotein PP28
FHF complex subunit HOOK-interacting protein C-terminal
Calcium-activated potassium channel subunit alpha-1
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Guanylate cyclase soluble subunit alpha-1
FLYWCH-type zinc finger-containing protein N-terminal
Centrosomal protein Cep63/Deup1 N-terminal
Potassium channel tetramerisation-type BTB
Lipocalin/cytosolic fatty-acid binding domain-containing protein
Glucosamine/galactosamine-6-phosphate isomerase
Large ribosomal subunit protein uL6 alpha-beta
Interactions with DUSP26, MAPK1 and MAPK2
DNA mismatch repair proteins mutS family
Saposin B-type domain-containing protein
TATA box binding protein associated factor (TAF) histone-like fold
Cyclic nucleotide phosphodiesterase catalytic
Protein phosphatase 1 regulatory subunit 15A/B C-terminal
Exocyst complex component Sec8 N-terminal
O-linked (Xyl...) (chondroitin sulfate) serine
Integrator complex subunit 14 C-terminal
Integrator complex subunit 14 beta-barrel
ER membrane protein complex subunit 1 C-terminal
Unique cartilage matrix-associated protein
Gamma tubulin complex component C-terminal
Gamma tubulin complex component protein N-terminal
Transcription elongation factor Eaf N-terminal
Interaction with APS and STAT5, and activation
Required for high-affinity SOCS3 binding
DRY motif; important for ligand-induced conformation changes and signaling
Important for species-specific agonist sensitivity
Bridge-like lipid transfer protein family member 1 C-terminal
Signal recognition particle 19 kDa protein
Sodium channel modifier 1 acidic C-terminal
O-glycosylated at seven sites with GalNAc
Protein phosphatase 1 regulatory subunit 21 N-terminal
Interaction with phosphotyrosine-containing peptide
Protein kinase C delta type catalytic subunit
Protein kinase C delta type regulatory subunit
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal
Ran-GTPase activating protein 1 C-terminal
Zinc finger BED domain-containing protein 5
Serine/arginine repetitive matrix protein C-terminal
Alpha-2-macroglobulin receptor-associated protein
Voltage-dependent calcium channel alpha-1 subunit IQ
Abolishes regulation by micromolar Ca(2+).
Decreases affinity for Ca(2+), but retains regulation by micromolar Ca(2+).
No effect on regulation by micromolar Ca(2+).
CCR4-Not complex component Not N-terminal
Protein transport protein Sec61 subunit gamma
LDL and other lipoprotein receptors binding
Lipid-binding and lipoprotein association
Cysteine sulfonic acid (-SO3H); alternate
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)
Translocon-associated protein subunit delta
Iron/zinc purple acid phosphatase-like C-terminal
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Centromere kinetochore component CENP-T N-terminal
Calcitonin receptor-stimulating peptide 1
FACT complex subunit Spt16 N-terminal lobe
Histone chaperone RTT106/FACT complex subunit SPT16-like middle
Immunoglobulin subtype domain-containing protein
Poly (ADP-ribose) glycohydrolase (PARG) catalytic
Spermatogenesis-associated protein 1 C-terminal
Ribonuclease A-domain domain-containing protein
DNA-directed RNA polymerase subunit 2 hybrid-binding
Interferon-related developmental regulator C-terminal
Interferon-related developmental regulator N-terminal
Thiamin pyrophosphokinase thiamin-binding
Uveal autoantigen with coiled-coil domains and ankyrin repeats
Mitochondrial brown fat uncoupling protein 1
Almost abolishes enzyme activity. Abolishes enzyme activity; when associated with A-396 or N-396.
Almost abolishes enzyme activity. Abolishes enzyme activity; when associated with A-521 or N-521.
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
Domain of unknown function with conserved HDNR motif
Bicarbonate transporter-like transmembrane
AF1; mediates transcriptional activation
AF2; mediates transcriptional activation
AF3; mediates transcriptional activation (in isoform B)
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
Mediates transcriptional transrepression (in isoform A)
Replication factor-A protein 1 N-terminal
Required for nuclear speckle localization
INO80 complex subunit B-like conserved region
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal
Platelet-derived growth factor (PDGF) family profile
Tumor necrosis factor receptor superfamily member 5
Oligosaccharyltransferase complex subunit OSTC
Dual specificity mitogen-activated protein kinase kinase 2
ATP-grasp fold succinyl-CoA synthetase-type
RecQ mediated genome instability protein 1-like N-terminal helical
Hairy/enhancer-of-split related with YRPW motif protein 1
Transcriptional repression and interaction with NCOR1 and SIN3A
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Vacuolar protein sorting-associated protein 52 homolog
Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Ubiquitin-activating enzyme E1 C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Transmembrane protein TMEM132 C-terminal
Transmembrane protein TMEM132 N-terminal
A-kinase anchor protein 7 RI-RII subunit-binding
Solute carrier family 2, facilitated glucose transporter member 4
Calcium-activated potassium channel subunit beta-1
Exocyst complex component Sec3 PIP2-binding N-terminal
Platelet-derived growth factor (PDGF) family profile domain-containing protein
Guanylate cyclase soluble subunit beta-1
Protein phosphatase 1 regulatory subunit 15B N-terminal
N6,N6,N6-trimethyllysine; by METTL21A; alternate
Small ribosomal subunit protein uS17 N-terminal
E3 ubiquitin-protein ligase Arkadia N-terminal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Cysteine persulfide intermediate; for sulfurtransferase activity
Glycyl thioester intermediate; for adenylyltransferase activity
Interchain (between alpha and beta chains)
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Signal recognition particle subunit SRP54
Methylcytosine dioxygenase TET1-3 oxygenase
Store-operated calcium entry-associated regulatory factor
C5a anaphylatoxin chemotactic receptor 1
Sodium/hydrogen exchanger regulatory region
Golgi associated RAB2 interactor protein-like Rab2B-binding
Has GTPase activity, required for proper localization
Required for phospholipid binding and regulation of the substrate preference
Oxidized purine nucleoside triphosphate hydrolase
dolichyl-phosphate beta-glucosyltransferase
Pentacotripeptide-repeat region of PRORP
Chromosome segregation protein Spc25 C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Important for beta-aspartyl-AMP intermediate formation
Clathrin/coatomer adaptor adaptin-like N-terminal
Coatomer beta subunit appendage platform
High affinity immunoglobulin epsilon receptor subunit gamma
Homologous-pairing protein 2 winged helix
ATP synthase F1 complex delta/epsilon subunit N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Gamma-aminobutyric acid receptor subunit gamma-2
May be a predisposing factor for congenital dwarfism.
Pituitary-specific positive transcription factor 1
Creates an additional N-glycosylation site. Decreases calcium binding and increases the rate of spontaneous Ca(2+) release from myocytes.
Endoribonuclease Regnase 1/ZC3H12 C-terminal
Glycoside hydrolase family 31 N-terminal
von Hippel-Lindau disease tumor suppressor
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9
3-beta hydroxysteroid dehydrogenase/isomerase
Gamma-butyrobetaine hydroxylase-like N-terminal
Calcitonin gene-related peptide type 1 receptor
Acyl-CoA-binding domain-containing protein 5
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Platelet-activating factor acetylhydrolase
Dual serine/threonine and tyrosine protein kinase
G2 and S phase-expressed protein 1 N-terminal
Required for interaction with prenylated RAB3A and VAMP2
Interchain (between heavy and light chains)
Potassium channel voltage dependent KCNQ C-terminal
Frequent in Golden retrievers and Labrador retrievers.
Inositol polyphosphate-related phosphatase
Solute carrier family 40 protein member 1
Nitration by tetranitromethane destroys a Ca(2+) binding site and inactivates enzyme
Interferon-induced GTP-binding protein Mx1
Glycine cleavage T-protein C-terminal barrel
Translation elongation factor IF5A C-terminal
6-phosphogluconate dehydrogenase C-terminal
Decreased IgE reactivity by approximately 15% compared to wild-type.
Decreased IgE reactivity by approximately 7% compared to wild-type.
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Histone-binding protein RBBP4 N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Ubiquinol-cytochrome C reductase hinge domain-containing protein
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
Platelet-derived growth factor subunit B
Nucleolar complex-associated protein 3 N-terminal
Required for nucleotide incorporation and primer extension rate
Required for optimal binding of telomeric ssDNA and incorporation of nucleotides at the second position of the template
Required for regulating specificity for telomeric DNA and for processivity for primer elongation
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Required for homodimerization and kinase activation and localization to the nucleus
Enhancer of mRNA-decapping protein 4 WD40 repeat region
May play an important role for the adaptation of the alcohol substrate into the binding site
May play an important role in catalytic activity
May play an important role in coenzyme binding
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
RNA polymerase III subunit RPC82-related helix-turn-helix
Chromatin assembly factor 1 subunit B C-terminal
Small ribosomal subunit protein uS15 N-terminal
Sperm acrosome membrane-associated protein 3
Exocyst complex subunit Sec15 C-terminal
Signaling lymphocytic activation molecule
Histone deacetylase complex subunit SAP30 Sin3 binding
Histone deacetylase complex subunit SAP30 zinc-finger
Asymmetric dimethylarginine; by CARM1; alternate
KH domain-containing RNA-binding protein QKI
Qua1 domain; involved in homodimerization
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Serine/threonine-protein phosphatase PP1-beta catalytic subunit
Spo11/DNA topoisomerase VI subunit A N-terminal
Potassium voltage-gated channel subfamily H member 2
Non-canonical purine NTP phosphatase/PRRC1
Sodium:neurotransmitter symporter serotonin N-terminal
Phosphoserine; by PKC/PRKCE and PKC/PRKCZ
Required for PIP2-mediated channel inhibition
Transient receptor potential cation channel subfamily V member 1
T-cell surface glycoprotein CD8 alpha chain
Peroxidase-like; mediates peroxidase activity
DBC1/CARP1 catalytically inactive NUDIX hydrolase
Amiloride-sensitive sodium channel subunit beta
U3 small nucleolar RNA-associated protein 13 C-terminal
Peptidoglycan recognition protein family
Abolishes tiotidine, but not cimetidine binding.
Diminishes histamine-stimulated activity.
Essential for tiotidine binding and H2 selectivity
YbaK/aminoacyl-tRNA synthetase-associated
Schiff-base intermediate with substrate; via topaquinone
Tumor necrosis factor receptor superfamily member 1A
Important for autoinhibition of adenylyltransferase activity
Cystic fibrosis transmembrane conductance regulator
Pseudouridine synthase I TruA alpha/beta
TERF1-interacting nuclear factor 2 N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Phosphomannose isomerase type I C-terminal
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
Transmembrane protein 131-like N-terminal
Transmembrane protein 131-like conserved
Rap guanine nucleotide exchange factor 2
Critical for specifying symmetric addition of methyl groups
TRF2-interacting telomeric protein/Rap1 C-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Retinoblastoma-associated protein C-terminal
Retinoblastoma-associated protein N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Guanine nucleotide-binding protein G(T) subunit gamma-T1
Vacuolar protein sorting-associated protein 54 C-terminal
Hepatocyte growth factor activator long chain
Hepatocyte growth factor activator short chain
Interchain (between short and long chains)
Signal recognition particle subunit SRP68
Aminoacyl-tRNA synthetase class I anticodon-binding
Ubiquitin carboxyl-terminal hydrolase 37
IMS import disulfide relay-system CHCH-CHCH-like Cx9C
Interchain (between beta and alpha chains)
Formamidopyrimidine-DNA glycosylase catalytic
Translin-associated factor X-interacting protein 1 N-terminal
GPI ethanolamine phosphate transferase 2 C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
TGF-beta family profile domain-containing protein
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Cathelicidin antimicrobial peptide C-terminal
Hydrophobic barrier that decreases the speed of ligand binding and dissociation
Alpha galactosidase A C-terminal beta-sandwich
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Insulin-like growth factor-binding protein 1
For hydroxyacyl-coenzyme A dehydrogenase activity
Important for hydroxyacyl-coenzyme A dehydrogenase activity
Important for long-chain enoyl-CoA hydratase activity
Essential for heterodimerization with RXRA
Peroxisome proliferator-activated receptor alpha
Required for heterodimerization with RXRA
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Cocaine- and amphetamine-regulated transcript protein
T-cell-specific surface glycoprotein CD28
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Ribosomal RNA adenine methylase transferase N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Kinetochore assembly subunit CENP-C N-terminal
1-acyl-sn-glycerol-3-phosphate acyltransferase
Polybasic region; required for nuclear import
Ras-related C3 botulinum toxin substrate 1
Dipeptidyl peptidase 1 exclusion domain chain
FXYD domain-containing ion transport regulator
Sphingolipid delta4-desaturase N-terminal
Phosphothreonine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis
Phosphotyrosine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis
Breast cancer type 1 susceptibility protein homolog
Piezo non-specific cation channel R-Ras-binding
HAUS augmin-like complex subunit 3 N-terminal
Platelet-derived growth factor receptor beta
Elongation factor 1 beta central acidic region eukaryote
Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange
Functional determinant of NMDA receptors
ATPsynthase alpha/beta subunit N-terminal extension
RNA 2-O ribose methyltransferase substrate binding
Nuclear condensin complex subunit 3 C-terminal
Interaction with galactose moiety of substrate glycoprotein
N6-(2-hydroxyisobutyryl)lysine; alternate
Reduces N-glycosylation but not apical targeting. Strongly reduces N-glycosylation but not apical targeting; when associated with Q-199 and Q-373.
Reduces N-glycosylation but not apical targeting. Strongly reduces N-glycosylation but not apical targeting; when associated with Q-199 and Q-383.
Reduces N-glycosylation but not apical targeting. Strongly reduces N-glycosylation but not apical targeting; when associated with Q-373 and Q-383.
cGMP-specific 3',5'-cyclic phosphodiesterase
4-carboxyglutamate; in a patient with Moyamoya disease
ABC-type uncharacterised transport system
Abscisic acid G-protein coupled receptor-like
NPC intracellular cholesterol transporter 2
Large ribosomal subunit protein uL30 N-terminal eukaryotes
Natural cytotoxicity triggering receptor 3
Exocyst complex component EXOC2/Sec5 N-terminal
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
Baculoviral IAP repeat-containing protein 3
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Deubiquitinating enzyme MINDY-3/4 conserved
Required for complex formation with BFSP1 and BFSP2
G-protein coupled receptors family 2 profile 2 domain-containing protein
Odontogenic ameloblast-associated protein
Arginine vasopressin-induced protein 1/transcriptional and immune response regulator
Small ribosomal subunit protein mS35 mitochondrial conserved
Alpha-ketoglutarate-dependent dioxygenase FTO catalytic
Interleukin-1 receptor accessory protein-like 1
Essential for transport from endoplasmic reticulum to Golgi apparatus and interaction with SAR1A
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
Required for the interaction with the SRP68/7SL RNA complex
Signal recognition particle subunit SRP72
Nuclear export signal; masked by the interaction with BRCA2
Important for interaction with membranes containing phosphoinositides
WAP four-disulfide core domain protein 2
Signal peptide, CUB domain and EGF like domain containing 2
S-Lysyl-methionine sulfilimine (Lys-Met) (interchain with M-1555)
S-Lysyl-methionine sulfilimine (Met-Lys) (interchain with K-1673)
Signal peptidase complex catalytic subunit SEC11A
DNA-directed RNA polymerase RBP11-like dimerisation
Receptor-type tyrosine-protein phosphatase alpha
NIF system FeS cluster assembly NifU N-terminal
GDP-fucose protein O-fucosyltransferase 1
Exocyst complex subunit Exo70 C-terminal
Scavenger receptor cysteine-rich type 1 protein M130
Decreases interaction with DYNLT1; when associated with A-138.
Decreases interaction with DYNLT1; when associated with A-139.
Disrupts interaction with DYNLT1; when associated with A-150.
Disrupts interaction with DYNLT1; when associated with A-151.
Rho guanine nucleotide exchange factor 2
Alanyl-transfer RNA synthetases family profile
Aspartate/homoserine dehydrogenase NAD-binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Calcineurin-binding protein cabin-1 MEF2-binding
Guanine nucleotide-binding protein G(i) subunit alpha-2
Voltage-gated hydrogen channel 1 C-terminal membrane-localisation
Pyrroline-5-carboxylate reductase dimerisation
receptor protein serine/threonine kinase
N-sulphoglucosamine sulphohydrolase C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Baculoviral IAP repeat-containing protein 5
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Ribosomal RNA-processing protein 7 C-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Decreasing protein levels. Loss of isomerohydrolase activity.
Decreasing protein levels. isomerohydrolase activity.
Does not affect isomerohydrolase activity.
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Hematopoietic progenitor cell antigen CD34
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit
Small ribosomal subunit protein uS2 C-terminal
Involved in condensin complex recruitment
Centriolar and ciliogenesis-associated protein HYLS1 C-terminal
Interchain (with C-99 in IL12A and C-76 in IL23A)
Cyclic nucleotide-gated cation channel beta-3
Histone deacetylase glutamine rich N-terminal
Spindle assembly abnormal protein 6 N-terminal
Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Phosphatidylinositol-specific phospholipase C X
Co-chaperone HscB C-terminal oligomerisation
Translation initiation factor beta propellor-like
C4-type zinc-finger of DNA polymerase delta
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
DNA/pantothenate metabolism flavoprotein C-terminal
GPI-GlcNAc transferase complex PIG-H component conserved
tRNA-splicing endonuclease subunit Sen54 N-terminal
Damage-control phosphatase ARMT1-like metal-binding
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
26S proteasome non-ATPase regulatory subunit RPN1 C-terminal
Peroxisome proliferator-activated receptor delta
NF-kappa-B essential modulator NEMO CC2-LZ
Important for obstruction of the ion pore in the closed conformation
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
Important for interaction with G proteins
Parathyroid hormone/parathyroid hormone-related peptide receptor
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Platelet-derived growth factor receptor alpha
Alpha-N-acetylglucosaminidase C-terminal
Alpha-N-acetylglucosaminidase N-terminal
Alpha-N-acetylglucosaminidase tim-barrel
Guanine nucleotide-binding protein G(q) subunit alpha
Transducer of regulated CREB activity C-terminal
Transducer of regulated CREB activity N-terminal
Transducer of regulated CREB activity middle
Histone RNA hairpin-binding protein RNA-binding
Phorbol-12-myristate-13-acetate-induced protein 1
A disintegrin and metallopeptidase domain 3-like
Chromosome segregation in meiosis protein 3
Tumor necrosis factor receptor superfamily member 11B
Nuclear receptor subfamily 4 group A member 1
Phosphoserine; by PKA, RPS6KA1 and RPS6KA3
Required for binding NBRE-containing DNA
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2
Requires for dimerization and lipid rafts association
Requires for interaction with MSN and EZR
Large ribosomal subunit protein uL6 N-terminal
Required for the correct localization of PALS1 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions
Transcription factor IIIC 90kDa subunit N-terminal
Transcription factor IIIC putative zinc-finger
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Necessary for transcriptional repression
DNA polymerase alpha/delta/epsilon subunit B
DNA polymerase epsilon subunit B N-terminal
Protein-glutamine gamma-glutamyltransferase K
Interacts with SPRY1, SPRY2, SPRY3 and SPRY4
Ferritin heavy chain, N-terminally processed
N-acetylthreonine; in Ferritin heavy chain, N-terminally processed
Granulocyte-macrophage colony-stimulating factor
Polypeptide N-acetylgalactosaminyltransferase
EGF domain-specific O-linked N-acetylglucosamine transferase
Conserved oligomeric Golgi complex subunit 4
BLOC-2 complex member HPS3 central region
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
non-specific serine/threonine protein kinase
Thymidylate synthase/dCMP hydroxymethylase
Cell division control protein 73 C-terminal
Thioredoxin domain-containing protein 12
Transcription initiation factor IIA gamma subunit C-terminal
Transcription initiation factor IIA gamma subunit N-terminal
Nuclear respiratory factor 1 NLS/DNA-binding dimerisation
Coatomer gamma subunit appendage Ig-like subdomain
Keratinocyte differentiation-associated protein
Glycylpeptide N-tetradecanoyltransferase C-terminal
Glycylpeptide N-tetradecanoyltransferase N-terminal
Signal peptidase complex catalytic subunit SEC11C
Cleavage stimulation factor subunit 1 dimerisation
Acid sphingomyelinase-like phosphodiesterase
Sphingomyelin phosphodiesterase C-terminal
Aldehyde dehydrogenase, dimeric NADP-preferring
Interaction with PYHIN1 and necessary for interaction with RFFL and RNF34
Sufficient to promote the mitochondrial pathway of apoptosis
Processed zona pellucida sperm-binding protein 2
RNA polymerase II-associated protein 1 C-terminal
RNA polymerase II-associated protein 1 N-terminal
Spermatid maturation protein 1 N-terminal
Required for endocytosis and down-regulation
Retinoic acid receptor responder protein 2
2 X 15 AA tandem repeats of L-[EQ]-[KR] [MV]-K-[EQ]-E-[IL]-[IL]-E-[AEV]-[FV]-[KRV]-[KQ]-E
Phosphoserine; by PKA, PKG/PRKG1, PKC and ROCK1
Phosphothreonine; by PKA, PKG/PRKG1 and AMPK
Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil
Harmonin-binding protein USHBP1 PDZ-binding
Interaction with membrane phospholipid headgroups
Tryptophan synthase beta chain-like PALP
G protein-regulated inducer of neurite outgrowth C-terminal
Nuclear receptor-binding factor 2 C-terminal
Epididymal secretory glutathione peroxidase
Proliferating cell nuclear antigen PCNA C-terminal
Proliferating cell nuclear antigen PCNA N-terminal
Nuclear speckle splicing regulatory protein 1 N-terminal
Nuclear speckle splicing regulatory protein 1 RS-like
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Required for self-association and interaction with PAFAH1B2 and PAFAH1B3
Nucleolar pre-ribosomal-associated protein 1 C-terminal
Nucleolar pre-ribosomal-associated protein 1 N-terminal
Ciliary neurotrophic factor receptor subunit alpha
DINNN-motif; mediates interaction with SPSB1, SPSB2 and SPSB4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4
HAUS augmin-like complex subunit 6 N-terminal
vitamin-K-epoxide reductase (warfarin-sensitive)
DNA polymerase alpha subunit B N-terminal
Mitochondrial apoptosis-inducing factor C-terminal
Interferon regulatory factor 2-binding protein 1 & 2 zinc finger
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel