Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
O-(3'-phospho-DNA)-tyrosine intermediate
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Major facilitator superfamily (MFS) profile
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
RNA polymerase sigma factor 70 region 4 type 2
Bacterial transcription activator effector binding
Plays an important role in discriminating NADH against NADPH
RNA methyltransferase SpoU/TrmH type C-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Pyridine nucleotide-disulphide oxidoreductase dimerisation
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Alpha-D-phosphohexomutase alpha/beta/alpha
Interaction with tRNA. Important for base-flipping
Interaction with tRNA; Important for base-flipping
Pseudouridine synthase I TruA alpha/beta
Proton acceptor; for glutaminase activity
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Flagellar hook-length control protein-like C-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
NADH:ubiquinone oxidoreductase 30kDa subunit
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Trimeric autotransporter adhesin YadA-like C-terminal membrane anchor
Integral membrane protein YccS N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
O-(phosphoribosyl dephospho-coenzyme A)serine
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Thiol:disulfide interchange protein DsbD N-terminal
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Penicillin-binding protein transpeptidase
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Membrane insertase YidC/Oxa/ALB C-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Threonine/serine exporter-like N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Peptidase S9 prolyl oligopeptidase catalytic
Penicillin-binding protein activator LpoA
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
DNA-directed DNA polymerase family A palm
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-98)
Tryptophan synthase beta chain-like PALP
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Outer membrane protein assembly factor BamB
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
Transglycosylase PBP1b N-terminal transmembrane
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Important for substrate binding and specificity
Solute-binding protein family 3/N-terminal
DNA polymerase III subunit delta C-terminal
Shikimate dehydrogenase substrate binding N-terminal
Alpha-glycerophosphate oxidase C-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Involved in allosteric activation by GTP
Required for zinc-mediated homotetramerization and catalytic activity
Cytochrome b561 bacterial/Ni-hydrogenase
CobB/CobQ-like glutamine amidotransferase
RNA 2-O ribose methyltransferase substrate binding
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Erythronate-4-phosphate dehydrogenase dimerisation
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Gamma-glutamylcyclotransferase AIG2-like
Survival protein SurE-like phosphatase/nucleotidase
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Polypeptide-transport-associated ShlB-type
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
TonB-dependent receptor-like beta-barrel
Thiol:disulfide interchange protein DsbD
Aconitase A/isopropylmalate dehydratase small subunit swivel
O-(5'-phospho-DNA)-tyrosine intermediate
Positions MEP for the nucleophilic attack
Schiff-base intermediate with substrate; via pyruvic acid
Organic solvent tolerance-like N-terminal
Transcription factor NikR nickel binding C-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Release factor glutamine methyltransferase N-terminal
May be important for providing the necessary conformational flexibility for enzymatic catalysis
Thymidylate synthase/dCMP hydroxymethylase
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Electron transfer via tryptophanyl radical
RNA binding; important for wobble base 34 recognition
Prokaryotic-type class I peptide chain release factors
Inosine/uridine-preferring nucleoside hydrolase
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Integrative conjugative element protein, RAQPRD family
Polymerase/histidinol phosphatase N-terminal
Large ribosomal subunit protein bL25 L25
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Anthranilate synthase component I N-terminal
Polysaccharide chain length determinant N-terminal
Interaction with polymerase core subunit RpoC
Outer membrane protein assembly factor BamE
Outer membrane protein assembly factor BamD
HupH hydrogenase expression protein C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Pyruvate phosphate dikinase AMP/ATP-binding
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Glucosamine/galactosamine-6-phosphate isomerase
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
ABC-type transport auxiliary lipoprotein component
Chromosome partition protein MukF C-terminal
Chromosome partition protein MukF middle
Chromosome partition protein MukF winged-helix
DNA mismatch repair proteins mutS family
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Cob(I)alamin adenosyltransferase N-terminal
Proline utilization A proline dehydrogenase N-terminal
Important for beta-aspartyl-AMP intermediate formation
Phosphoadenosine phosphosulphate reductase
Gly-cisPro motif, important for rejection of L-amino acids
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Important for interaction with partner proteins
Type II restriction enzyme and methyltransferase RM.Eco57I-like
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Glycosyltransferase subfamily 4-like N-terminal
Translation elongation factor P/YeiP central
Transcriptional regulator AbiEi antitoxin N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Ionotropic glutamate receptor C-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Pyruvate dehydrogenase E1 component middle
Prolyl 3,4-dihydroxylase TPA1/OFD1 N-terminal
Transcriptional regulator SgrR N-terminal HTH
N6 adenine-specific DNA methyltransferase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Trimeric autotransporter adhesin YadA-like stalk
Alanyl-transfer RNA synthetases family profile
DnaJ homologue subfamily C member 28 conserved
DNA polymerase III delta subunit C-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Cytochrome c-type biogenesis protein CcmF C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Polysaccharide lyase family 8 C-terminal
Menaquinone biosynthesis protein MenD middle
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Interacts with tRNA; defines subfamily-specific binding signature
Glycosyl transferase family 3 N-terminal
Large ribosomal subunit protein uL15/eL18
L-seryl-tRNA selenium transferase N-terminal
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Flagella basal body P-ring formation protein FlgA
Magnesium transporter MgtE intracellular
N-sulphoglucosamine sulphohydrolase C-terminal
High-affinity zinc uptake system protein ZnuA
Major facilitator superfamily associated
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Phosphotransferase system enzyme I N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Cation-transporting P-type ATPase N-terminal
Negative modulator of initiation of replication SeqA N-terminal
Replication modulator SeqA C-terminal DNA-binding
Flagellar motor switch protein FliN-like C-terminal
Haem-binding uptake Tiki superfamily ChaN
Phosphocysteine intermediate; for EIIB activity
Small ribosomal subunit protein uS4 N-terminal
Prepilin type IV endopeptidase peptidase
Could be important to modulate the pK values of the two catalytic cysteine residues
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Aspartate/homoserine dehydrogenase NAD-binding
Lipopolysaccharide export system protein LptA
Periplasmic binding protein/LacI sugar binding
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
Plays a key role in the stabilization of the transition state and positioning the aldehyde component
Resolvase/invertase-type recombinase catalytic
NIF system FeS cluster assembly NifU C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Carbamoyl-phosphate synthase small subunit N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Ribosomal RNA adenine methylase transferase N-terminal
Transferrin binding protein-like solute binding protein
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Reversibly protonated during proton transport
Mandelate racemase/muconate lactonizing enzyme C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Mechanosensitive ion channel inner membrane
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Nucleoside-specific channel-forming protein Tsx
Molybdopterin cofactor biosynthesis C (MoaC)
Terminase large subunit-like endonuclease
Sodium/calcium exchanger membrane region
Cysteine sulfenic acid (-SOH) intermediate
Glycine-zipper-containing OmpA-like membrane
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Involved in proton transfer during cleavage
Plays an important role in substrate specificity
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Aromatic amino acid beta-eliminating lyase/threonine aldolase
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
Increases nucleophilicity of active site Cys
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
6-phosphogluconate dehydrogenase C-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Essential for prephenate dehydratase activity
Periplasmic nitrate reductase, electron transfer subunit
Proton acceptor; for decarboxylase activity
Proton donor; for decarboxylase activity
Proton donor; for formyltransferase activity
Superoxide dismutase copper/zinc binding
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Non-canonical purine NTP phosphatase/PRRC1
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Disulphide bond isomerase DsbC/G N-terminal
Bacterial type II secretion system protein E
Flagellar motor switch protein FliN N-terminal
Outer-membrane lipoprotein carrier protein
NIF system FeS cluster assembly NifU N-terminal
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Large ribosomal subunit protein uL6 alpha-beta
ATP synthase F1 complex delta/epsilon subunit N-terminal
Glycine cleavage T-protein C-terminal barrel
Outer membrane protein assembly factor BamA
YbaK/aminoacyl-tRNA synthetase-associated
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
DNA mismatch repair MutH/Type II restriction enzyme Sau3AI
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Schiff-base intermediate with acetaldehyde
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Large ribosomal subunit protein uL2 C-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Appears to be important in orienting the phosphate for catalysis
Translocation and assembly module subunit TamA
TRAP C4-dicarboxylate transport system permease DctM subunit
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Type I restriction modification DNA specificity
Lysidine-tRNA(Ile) synthetase C-terminal
Endolytic peptidoglycan transglycosylase RlpA
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Type IV secretion system coupling protein TraD DNA-binding
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Dinitrogenase iron-molybdenum cofactor biosynthesis
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Exonuclease VII large subunit C-terminal
Regulator of nucleoside diphosphate kinase N-terminal
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Terminase large subunit gp17-like C-terminal
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal