TonB-dependent receptor-like beta-barrel
Major facilitator superfamily (MFS) profile
O-(5'-phospho-DNA)-tyrosine intermediate
Inosine/uridine-preferring nucleoside hydrolase
NIF system FeS cluster assembly NifU N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Surface antigen domain-containing protein
Flagellar motor switch protein FliN-like C-terminal
Large ribosomal subunit protein uL2 C-terminal
Bacterial type II secretion system protein E
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Solute-binding protein family 3/N-terminal
CobB/CobQ-like glutamine amidotransferase
Involved in tetramerization or stability of the tetramer
Small-conductance mechanosensitive channel
PHA accumulation regulator DNA-binding N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
SsuA/THI5-like domain-containing protein
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Polypeptide-transport-associated ShlB-type
RND efflux pump membrane fusion protein barrel-sandwich
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Spore coat protein U domain-containing protein
Metallo-beta-lactamase domain-containing protein
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Positions MEP for the nucleophilic attack
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Membrane fusion protein biotin-lipoyl like
Blue (type 1) copper domain-containing protein
Cytochrome b561 bacterial/Ni-hydrogenase
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Outer membrane protein beta-barrel domain-containing protein
Penicillin-binding protein transpeptidase
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Aspartate/homoserine dehydrogenase NAD-binding
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Prepilin type IV endopeptidase peptidase
Glycine zipper domain-containing protein
Heme-copper oxidase subunit III family profile
DNA-directed DNA polymerase family B multifunctional
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Tryptophan synthase beta chain-like PALP
Moybdenum cofactor oxidoreductase dimerisation
Quercetin 2,3-dioxygenase C-terminal cupin
Ribosomal RNA adenine methylase transferase N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Autotransporter domain-containing protein
Chromosomal replication initiator DnaA C-terminal
Electron transfer via tryptophanyl radical
Glucose-methanol-choline oxidoreductase N-terminal
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS domain-containing protein
Rap1a immunity protein domain-containing protein
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Aminoacyl-transfer RNA synthetases class-II family profile
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Glucan biosynthesis periplasmic MdoG C-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Alanyl-transfer RNA synthetases family profile
Pyridoxamine 5'-phosphate oxidase putative
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Cation-transporting P-type ATPase N-terminal
Glycine cleavage T-protein C-terminal barrel
Required for zinc-mediated homotetramerization and catalytic activity
Alpha-D-phosphohexomutase alpha/beta/alpha
Activator of Hsp90 ATPase homologue 1-like C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Ysc84 actin-binding domain-containing protein
Bacterial bifunctional deaminase-reductase C-terminal
Glycine zipper 2TM domain-containing protein
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Flagellar hook-length control protein-like C-terminal
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Pyruvate dehydrogenase E1 component middle
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Pyruvate phosphate dikinase AMP/ATP-binding
Guanylate kinase/L-type calcium channel beta subunit
Pyrimidine nucleoside phosphorylase C-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Phosphotransferase system enzyme I N-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Important for interaction with partner proteins
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Bacterial collagen-like protein middle domain-containing protein
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Lytic transglycosylase superhelical linker
Glycosyltransferase subfamily 4-like N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Solute-binding protein family 3/N-terminal domain-containing protein
Saccharopine dehydrogenase-like C-terminal
DNA polymerase III subunit delta C-terminal
Ionotropic glutamate receptor C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Sodium/calcium exchanger membrane region
Transposase IS204/IS1001/IS1096/IS1165 DDE
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Thymidylate synthase/dCMP hydroxymethylase
Glucose-methanol-choline oxidoreductase C-terminal
Type I restriction modification DNA specificity
Defence against restriction A N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
TRAP C4-dicarboxylate transport system permease DctM subunit
UDP N-acetylglucosamine O-acyltransferase C-terminal
YMGG-like Gly-zipper domain-containing protein
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Proline utilization A proline dehydrogenase N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Flagellar assembly protein FliH/Type III secretion system HrpE
Type III secretion system flagellar brake protein YcgR PilZN
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Nitrite/Sulfite reductase ferredoxin-like
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
L-seryl-tRNA selenium transferase N-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Ribose-phosphate pyrophosphokinase N-terminal
NADH-rubredoxin oxidoreductase C-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
AB hydrolase-1 domain-containing protein
Histidine-specific methyltransferase SAM-dependent
Glucosamine/galactosamine-6-phosphate isomerase
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Molybdopterin cofactor biosynthesis C (MoaC)
Toxin co-regulated pilus biosynthesis protein Q C-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:ubiquinone/plastoquinone oxidoreductase chloroplast chain 5 C-terminal
Restriction system protein Mrr-like N-terminal
HTH-type transcriptional regulator MT1864/Rv1816-like C-terminal
Glycoside-hydrolase family GH114 TIM-barrel
DNA-directed DNA polymerase family A palm
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Biopterin-dependent aromatic amino acid hydroxylase family profile
FAD dependent oxidoreductase domain-containing protein
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Survival protein SurE-like phosphatase/nucleotidase
Cobalamin-independent methionine synthase MetE N-terminal
Type VI secretion system IcmF C-terminal
Small ribosomal subunit protein uS4 N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Anthranilate synthase component I N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Peptidoglycan recognition protein family
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
Plays an important role in substrate specificity
Outer-membrane lipoprotein carrier protein
Aminoacyl-tRNA synthetase class I anticodon-binding
Lipoprotein SmpA/OmlA domain-containing protein
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Outer membrane protein assembly factor BamC
RNA 2-O ribose methyltransferase substrate binding
Cobaltochelatase subunit CobS N-terminal
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Sodium symporter small subunit predicted
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Pertactin central region domain-containing protein
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Plays an important role in discriminating NADH against NADPH
Endoribonuclease L-PSP/chorismate mutase-like
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Carbamoyl-phosphate synthase small subunit N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
6-phosphogluconate dehydrogenase C-terminal
Prokaryotic-type class I peptide chain release factors
Microcin J25-processing protein McjB C-terminal
Alpha-glycerophosphate oxidase C-terminal
Interaction with polymerase core subunit RpoC
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Putative regulatory protein FmdB Zinc ribbon
Cysteine sulfenic acid (-SOH) intermediate
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Glycosyl transferase family 3 N-terminal
Soluble ligand binding domain-containing protein
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Gamma-butyrobetaine hydroxylase-like N-terminal
Helix-hairpin-helix DNA-binding motif class 1
Reversibly protonated during proton transport
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
BAAT/Acyl-CoA thioester hydrolase C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Contractile injection system tube protein N-terminal
Pseudouridine synthase I TruA alpha/beta
Chromosomal replication initiator protein DnaA
Membrane insertase YidC/Oxa/ALB C-terminal
Fe/B12 periplasmic-binding domain-containing protein
Gly-cisPro motif, important for rejection of L-amino acids
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Regulator of nucleoside diphosphate kinase N-terminal
PhoD-like phosphatase metallophosphatase
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
DNA mismatch repair proteins mutS family
Proton acceptor; for glutaminase activity
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Could be important to modulate the pK values of the two catalytic cysteine residues
Polymerase/histidinol phosphatase N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Exonuclease VII large subunit C-terminal
Integral membrane protein YccS N-terminal
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
Outer membrane protein OmpA-like transmembrane
Outer membrane protein OmpA-like transmembrane domain-containing protein
MalT-like TPR region domain-containing protein
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
Translation elongation factor P/YeiP central
N-end rule aminoacyl transferase C-terminal
Mannose-6-phosphate isomerase type II C-terminal
Adaptive response protein AidB N-terminal
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Peptide methionine sulphoxide reductase MsrA
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
PapC-like C-terminal domain-containing protein
Large ribosomal subunit protein uL6 alpha-beta
Large ribosomal subunit protein uL15/eL18
ABC transporter substrate-binding protein PnrA-like
ABC transporter substrate-binding protein PnrA-like domain-containing protein
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Required for dimer formation and molybdate binding
RNA binding; important for wobble base 34 recognition
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Gamma-glutamylcyclotransferase AIG2-like
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
40-residue YVTN family beta-propeller repeat protein
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Essential for prephenate dehydratase activity