Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
RND efflux pump membrane fusion protein barrel-sandwich
Carbamoyl-phosphate synthase small subunit N-terminal
Cell wall binding repeat-containing protein
Peptidase S9 prolyl oligopeptidase catalytic
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Small ribosomal subunit protein uS4 N-terminal
Choloylglycine hydrolase/NAAA C-terminal
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Methionyl-tRNA synthetase anticodon-binding
Alanyl-transfer RNA synthetases family profile
Membrane fusion protein biotin-lipoyl like
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Glycosyl hydrolase family 30 beta sandwich
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
NADH-rubredoxin oxidoreductase C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
O-(5'-phospho-DNA)-tyrosine intermediate
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Pseudouridine synthase I TruA alpha/beta
Polysaccharide biosynthesis protein CapD-like
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Tryptophan synthase beta chain-like PALP
RNA polymerase sigma factor 70 region 4 type 2
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Alpha-D-phosphohexomutase alpha/beta/alpha
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Cadherin-like beta sandwich domain-containing protein
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Ribose-phosphate pyrophosphokinase N-terminal
Nitrite/Sulfite reductase ferredoxin-like
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Glycogen debranching enzyme bacterial and archaeal type N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Mannose-6-phosphate isomerase type II C-terminal
Major facilitator superfamily (MFS) profile
Penicillin-binding protein transpeptidase
Glutathionylspermidine synthase pre-ATP-grasp-like
O-(phosphoribosyl dephospho-coenzyme A)serine
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Polysaccharide biosynthesis protein C-terminal
NIF system FeS cluster assembly NifU N-terminal
Glycoside hydrolase family 31 N-terminal
Solute-binding protein family 3/N-terminal
Phosphocysteine intermediate; for EIIB activity
Prepilin type IV endopeptidase peptidase
Bacterial Ig-like domain-containing protein
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Interaction with polymerase core subunit RpoC
Schiff-base intermediate with D-ribose 5-phosphate
DNA mismatch repair proteins mutS family
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Aminoacyl-tRNA synthetase class II (G/ P/ S/T)
Alpha-L-rhamnosidase six-hairpin glycosidase
Glycosyltransferase subfamily 4-like N-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Cation-transporting P-type ATPase N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Prokaryotic-type class I peptide chain release factors
non-reducing end alpha-L-arabinofuranosidase
Calpain catalytic domain-containing protein
Important for beta-aspartyl-AMP intermediate formation
Shikimate dehydrogenase substrate binding N-terminal
Plays an important role in substrate specificity
Reversibly protonated during proton transport
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Thymidylate synthase/dCMP hydroxymethylase
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Large ribosomal subunit protein uL2 C-terminal
Chromosomal replication initiator DnaA C-terminal
Bacterial alpha-L-rhamnosidase N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
tRNA pseudouridylate synthase B C-terminal
Bacterial type II secretion system protein E
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Exonuclease VII large subunit C-terminal
D-galactose/methyl-galactoside binding periplasmic protein MglB
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Polymerase/histidinol phosphatase N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Positions MEP for the nucleophilic attack
Glucosamine/galactosamine-6-phosphate isomerase
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Glycosyl transferase family 28 C-terminal
Ionotropic glutamate receptor C-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Glycoside hydrolase family 42 N-terminal
Flagellar Assembly Protein A N-terminal region
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
S-adenosylmethionine-dependent methyltransferase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Copper amine oxidase-like N-terminal domain-containing protein
Fatty acid kinase subunit A-like C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Threonine/serine exporter-like N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
BAAT/Acyl-CoA thioester hydrolase C-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Bacterial transcription activator effector binding
serine-type D-Ala-D-Ala carboxypeptidase
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Nicotinamide phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Signal transduction histidine kinase internal region
Neutral/alkaline non-lysosomal ceramidase N-terminal
Release factor glutamine methyltransferase N-terminal
Flagellar motor switch protein FliN-like C-terminal
Phosphomannose isomerase type I catalytic
Could play a key role in the communication between the regulatory and the substrate sites
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Anthranilate synthase component I N-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease 3
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Glycosyl transferase family 3 N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Diacylglycerol glucosyltransferase N-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Important for substrate specificity; cannot use PPi as phosphoryl donor
Dinitrogenase iron-molybdenum cofactor biosynthesis
Helix-hairpin-helix DNA-binding motif class 1
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
ATP synthase F1 complex delta/epsilon subunit N-terminal
Peptidase C-terminal archaeal/bacterial domain-containing protein
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Lysozyme inhibitor LprI N-terminal domain-containing protein
Restriction endonuclease type II DpnII-like
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Proton acceptor; for glutaminase activity
NIF system FeS cluster assembly NifU C-terminal
Alpha galactosidase C-terminal beta sandwich
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Polysaccharide chain length determinant N-terminal
Extracellular endo-alpha-(1->5)-L-arabinanase C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Translation elongation factor P/YeiP central
Large ribosomal subunit protein uL15/eL18
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Elongation factor G-binding protein N-terminal
Type III secretion system flagellar brake protein YcgR PilZN
Terminase large subunit-like endonuclease
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Schiff-base intermediate with acetoacetate
Right handed beta helix domain-containing protein
Putative aromatic acid exporter C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
6-hydroxymethylpterin diphosphokinase MptE-like
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
SUF system FeS cluster assembly SufBD N-terminal
Resolvase/invertase-type recombinase catalytic
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Peptidase M10 metallopeptidase domain-containing protein
Ribosomal RNA adenine methylase transferase N-terminal
Peptide methionine sulphoxide reductase MsrA
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Could be important to modulate the pK values of the two catalytic cysteine residues
General stress protein FMN-binding split barrel
CD-NTase-associated protein 12/Pycsar effector protein TIR
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Sugar fermentation stimulation protein C-terminal
5-glutamyl coenzyme A thioester intermediate
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Probable transposase IS891/IS1136/IS1341
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Glycosyltransferase family 28 N-terminal
Sodium/calcium exchanger membrane region
Activator of Hsp90 ATPase homologue 1-like C-terminal
Sporulation stage IV protein A C-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Cell envelope-related transcriptional attenuator
Pyruvate phosphate dikinase AMP/ATP-binding
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Butirosin biosynthesis protein H N-terminal
Sporulation stage II protein D amidase enhancer LytB N-terminal
Septum formation inhibitor MinC C-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Siroheme decarboxylase AsnC-like ligand binding
Cytochrome C biogenesis protein transmembrane
Thiamin pyrophosphokinase thiamin-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
DNA replication/recombination mediator RecO N-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
DNA polymerase III delta subunit C-terminal
Gly-cisPro motif, important for rejection of L-amino acids
RNA 2-O ribose methyltransferase substrate binding
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Important for autoinhibition of adenylyltransferase activity
ABC transporter substrate-binding protein PnrA-like
RNA binding; important for wobble base 34 recognition
Involved in allosteric activation by GTP
Phosphoribosylformylglycinamidine synthase linker
Flagellar assembly protein FliH/Type III secretion system HrpE
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Schiff-base intermediate with acetaldehyde
Transcription factor NikR nickel binding C-terminal
Transcription regulator AsnC/Lrp ligand binding
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Saccharopine dehydrogenase-like C-terminal
Glycoside hydrolase GH146 substrate-binding
Membrane insertase YidC/Oxa/ALB C-terminal
Flagellar hook-length control protein-like C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Global transcriptional regulator CodY C-terminal
Global transcriptional regulator CodY N-terminal
Phosphotransferase system enzyme I N-terminal
DNA-directed DNA polymerase family A palm
Pyruvate ferredoxin oxidoreductase beta subunit C-terminal
Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
Aminoacyl-tRNA synthetase class I anticodon-binding
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Essential for prephenate dehydratase activity