Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Resolvase/invertase-type recombinase catalytic
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Polymerase/histidinol phosphatase N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
4'-phosphopantetheinyl transferase N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Major facilitator superfamily (MFS) profile
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
RNA 2-O ribose methyltransferase substrate binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Cytochrome C biogenesis protein transmembrane
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Gram-positive cocci surface proteins LPxTG
Aminoacyl-transfer RNA synthetases class-II family profile
Positions MEP for the nucleophilic attack
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Sodium/calcium exchanger membrane region
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
PhoD-like phosphatase metallophosphatase
Molybdopterin cofactor biosynthesis C (MoaC)
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Plays an important role in substrate specificity
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Peptidase M1 membrane alanine aminopeptidase
Tryptophan synthase beta chain-like PALP
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Thymidylate synthase/dCMP hydroxymethylase
Bacterial bifunctional deaminase-reductase C-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Membrane insertase YidC/Oxa/ALB C-terminal
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Phosphatidic acid phosphatase type 2/haloperoxidase
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Endoribonuclease L-PSP/chorismate mutase-like
Aconitase A/isopropylmalate dehydratase small subunit swivel
Cysteine sulfenic acid (-SOH) intermediate
Shikimate dehydrogenase substrate binding N-terminal
Schiff-base intermediate with D-ribose 5-phosphate
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
CobB/CobQ-like glutamine amidotransferase
O-(3'-phospho-DNA)-tyrosine intermediate
Prokaryotic-type class I peptide chain release factors
Alpha-glycerophosphate oxidase C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Schiff-base intermediate with acetaldehyde
Phosphatidate phosphatase APP1 catalytic
Solute-binding protein family 5 domain-containing protein
ABC transporter substrate-binding protein
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Penicillin-binding protein transpeptidase
Methionyl-tRNA synthetase anticodon-binding
Inosine/uridine-preferring nucleoside hydrolase
Could be important to modulate the pK values of the two catalytic cysteine residues
Peptidoglycan recognition protein family
Peptidoglycan recognition protein family domain-containing protein
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Interaction with polymerase core subunit RpoC
Glucosamine/galactosamine-6-phosphate isomerase
YbaK/aminoacyl-tRNA synthetase-associated
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Phosphoribosylformylglycinamidine synthase linker
Activator of Hsp90 ATPase homologue 1-like C-terminal
Pyruvate dehydrogenase E1 component middle
Protocatechuate 3,4-dioxygenase beta subunit N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Anthranilate synthase component I N-terminal
Important for substrate specificity; cannot use PPi as phosphoryl donor
Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein
Fe/B12 periplasmic-binding domain-containing protein
ATP synthase F1 complex delta/epsilon subunit N-terminal
Resuscitation-promoting factor Rpf1 C-terminal
Resuscitation-promoting factor core lysozyme-like
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
TRAP C4-dicarboxylate transport system permease DctM subunit
Alanyl-transfer RNA synthetases family profile
Solute-binding protein family 3/N-terminal
Glycosyltransferase subfamily 4-like N-terminal
SsuA/THI5-like domain-containing protein
Protein O-mannosyl-transferase C-terminal four TM
Urea ABC transporter substrate-binding protein
Restriction system protein Mrr-like N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Cell envelope-related transcriptional attenuator
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Nitrite/Sulfite reductase ferredoxin-like
Ribose-phosphate pyrophosphokinase N-terminal
Peptide methionine sulphoxide reductase MsrA
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
6-phosphogluconate dehydrogenase C-terminal
Phosphocysteine intermediate; for EIIB activity
Gram-positive pilin subunit D1 N-terminal
Gram-positive pilin subunit D1 N-terminal domain-containing protein
Phosphatidylglycerol lysyltransferase C-terminal
Chromosomal replication initiator DnaA C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Large ribosomal subunit protein uL15/eL18
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Na+/H+ antiporter MnhB subunit-related protein
Aminoacyl-tRNA synthetase class I anticodon-binding
Phenol hydroxylase C-terminal dimerisation
O-(5'-phospho-DNA)-tyrosine intermediate
Cytochrome b/b6 N-terminal region profile
Phosphomannose isomerase type I catalytic
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Helix-hairpin-helix DNA-binding motif class 1
Release factor glutamine methyltransferase N-terminal
Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-? in acceptor proteins)
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Translation elongation factor P/YeiP central
Glycosyl transferase family 3 N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
ATP-dependent DNA helicase RecG C-terminal
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Sporulation transcription regulator WhiA N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Involved in ionization of N3 of dUMP, leading to its activation
Pseudouridine synthase I TruA alpha/beta
Solute-binding protein family 3/N-terminal domain-containing protein
Important for beta-aspartyl-AMP intermediate formation
Prepilin type IV endopeptidase peptidase
Reversibly protonated during proton transport
Polysaccharide biosynthesis protein C-terminal
Large ribosomal subunit protein uL2 C-terminal
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Methylguanine DNA methyltransferase ribonuclease-like
Exonuclease VII large subunit C-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Electron transfer via tryptophanyl radical
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
NIF system FeS cluster assembly NifU N-terminal
Cobalamin-independent methionine synthase MetE N-terminal
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Could play a key role in the communication between the regulatory and the substrate sites
Myo-inositol-1-phosphate synthase GAPDH-like
Arabinofuranosyltransferase AftA C-terminal
Arabinofuranosyltransferase AftA N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Meso-diaminopimelate D-dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
SGNH hydrolase-type esterase domain-containing protein
Heat-inducible transcription repressor HrcA C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Essential for prephenate dehydratase activity
Small ribosomal subunit protein uS4 N-terminal
SUF system FeS cluster assembly SufBD N-terminal
DNA replication/recombination mediator RecO N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Trigger factor ribosome-binding bacterial
Gly-cisPro motif, important for rejection of L-amino acids