PhoD-like phosphatase metallophosphatase
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Major facilitator superfamily (MFS) profile
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
RNA polymerase sigma factor 70 region 4 type 2
TRAP C4-dicarboxylate transport system permease DctM subunit
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
YbaK/aminoacyl-tRNA synthetase-associated
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Urease accessory protein UreH-like transmembrane
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
RND efflux pump membrane fusion protein barrel-sandwich
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Putative type VI secretion system Rhs element associated Vgr
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Large ribosomal subunit protein uL15/eL18
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Large ribosomal subunit protein uL6 alpha-beta
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Na+/H+ antiporter MnhB subunit-related protein
Release factor glutamine methyltransferase N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Glycosyltransferase subfamily 4-like N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Transposase IS116/IS110/IS902 C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Histidine-specific methyltransferase SAM-dependent
Activator of Hsp90 ATPase homologue 1-like C-terminal
TonB-dependent receptor-like beta-barrel
Acetyl-CoA hydrolase/transferase C-terminal
TRAP transporter solute receptor, TAXI family
Translocation and assembly module subunit TamA
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Penicillin-binding protein transpeptidase
Flagellar hook-length control protein-like C-terminal
Important for substrate binding and specificity
Plays an important role in substrate specificity
O-(3'-phospho-DNA)-tyrosine intermediate
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Type II secretion system protein GspI C-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Helix-hairpin-helix DNA-binding motif class 1
O-(5'-phospho-DNA)-tyrosine intermediate
RND type efflux pump involved in aminoglycoside resistance
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Bacterial type II secretion system protein E
Could be important to modulate the pK values of the two catalytic cysteine residues
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Alanyl-transfer RNA synthetases family profile
Exonuclease VII large subunit C-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
NIF system FeS cluster assembly NifU C-terminal
Outer membrane protein assembly factor BamA
Cysteine sulfenic acid (-SOH) intermediate
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Solute-binding protein family 3/N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Pyruvate phosphate dikinase AMP/ATP-binding
Type II secretion system protein GspC N-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
N-end rule aminoacyl transferase C-terminal
NADH-rubredoxin oxidoreductase C-terminal
Sulfatase-modifying factor enzyme domain-containing protein
Outer membrane protein beta-barrel domain-containing protein
Alpha-D-phosphohexomutase alpha/beta/alpha
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Glycosyl transferase family 3 N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Nitrite/Sulfite reductase ferredoxin-like
RNA methyltransferase SpoU/TrmH type C-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Water stress and hypersensitive response
Water stress and hypersensitive response domain-containing protein
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Interaction with polymerase core subunit RpoC
Type II secretion system protein GspG C-terminal
Outer-membrane lipoprotein Wza C-terminal
Outer-membrane lipoprotein carrier protein
Prokaryotic-type class I peptide chain release factors
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Thiolase-like protein type 1 additional C-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
DNA-directed DNA polymerase family A palm
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
D-glutamate N-acetyltransferase-like C-terminal
D-glutamate N-acetyltransferase-like N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Important for interaction with partner proteins
Neutral/alkaline non-lysosomal ceramidase N-terminal
Tryptophan synthase beta chain-like PALP
Arsenosugar biosynthesis radical SAM protein ArsS-like C-terminal
4'-phosphopantetheinyl transferase N-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
Small ribosomal subunit protein uS4 N-terminal
Large ribosomal subunit protein uL2 C-terminal
Sodium/calcium exchanger membrane region
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
Aminoacyl-tRNA synthetase class I anticodon-binding
Adaptive response protein AidB N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
RAQPRD family integrative conjugative element protein
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Membrane fusion protein biotin-lipoyl like
Pseudouridine synthase I TruA alpha/beta
Anthranilate synthase component I N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Organic solvent tolerance-like N-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Aconitase A/isopropylmalate dehydratase small subunit swivel
Essential for prephenate dehydratase activity
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Arginine decarboxylase C-terminal helical
Cytochrome oxidase subunit II copper A binding
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Transcriptional regulator AbiEi antitoxin N-terminal
Alpha-glycerophosphate oxidase C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Cytochrome c-type biogenesis protein CcmF C-terminal
Flagella basal body P-ring formation protein FlgA
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Polymerase/histidinol phosphatase N-terminal
Prepilin type IV endopeptidase peptidase
Flagellar motor switch protein FliN-like C-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
SUF system FeS cluster assembly SufBD N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Phosphatidate phosphatase APP1 catalytic
Endolytic peptidoglycan transglycosylase RlpA
Sodium symporter small subunit predicted
ABC transporter substrate-binding protein
Schiff-base intermediate with substrate; via pyruvic acid
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Disulphide bond isomerase DsbC/G N-terminal
Type I restriction modification DNA specificity
Regulator of nucleoside diphosphate kinase N-terminal
Putative regulatory protein FmdB Zinc ribbon
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Chromosomal replication initiator DnaA C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Translation elongation factor P/YeiP central
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Sugar fermentation stimulation protein C-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Phenol hydroxylase C-terminal dimerisation
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
Lytic transglycosylase superhelical linker
DNA mismatch repair proteins mutS family
Survival protein SurE-like phosphatase/nucleotidase
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
S-adenosylmethionine-dependent methyltransferase
Mandelate racemase/muconate lactonizing enzyme C-terminal
Chromosomal replication initiator protein DnaA
Peptidoglycan binding-like domain-containing protein
Beta-lactamase hydrolase-like protein phosphatase-like
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Cytochrome oxidase subunit II transmembrane region profile
RNA 2-O ribose methyltransferase substrate binding
S-adenosyl-L-homocysteine hydrolase NAD binding
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Heme-copper oxidase subunit III family profile
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Bacterial transcription activator effector binding
ATP synthase F1 complex delta/epsilon subunit N-terminal
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Trimeric autotransporter adhesin YadA-like C-terminal membrane anchor
Trimeric autotransporter adhesin YadA-like head
Trimeric autotransporter adhesin YadA-like stalk
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Polysaccharide chain length determinant N-terminal
Type VI secretion system IcmF C-terminal
Interacts with tRNA; defines subfamily-specific binding signature
Butirosin biosynthesis protein H N-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Thymidylate synthase/dCMP hydroxymethylase
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Lysidine-tRNA(Ile) synthetase C-terminal
Involved in tetramerization or stability of the tetramer
Peptide methionine sulphoxide reductase MsrA
Glycine cleavage T-protein C-terminal barrel
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
DNA replication/recombination mediator RecO N-terminal
Antitoxin Xre/MbcA/ParS-like toxin-binding
Ribose-phosphate pyrophosphokinase N-terminal
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
ATP-dependent DNA helicase RecG C-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
DNA polymerase III delta subunit C-terminal
BetI-type transcriptional repressor C-terminal
Pyruvate dehydrogenase E1 component middle
Peptidase S9 prolyl oligopeptidase catalytic
Methylamine/Aralkylamine dehydrogenase light chain C-terminal
Tryptophylquinone 6'-substrate hemiaminal intermediate
Quercetin 2,3-dioxygenase C-terminal cupin
ABC transporter substrate-binding protein PnrA-like
Ionotropic glutamate receptor C-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Peptide methionine sulfoxide reductase MsrA