UDP-glucose/GDP-mannose dehydrogenase C-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Homogentisate 1,2-dioxygenase N-terminal
Alpha-glycerophosphate oxidase C-terminal
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
RNA polymerase sigma factor 70 region 4 type 2
Activator of Hsp90 ATPase homologue 1-like C-terminal
LamG-like jellyroll fold domain-containing protein
Peptidase M1 membrane alanine aminopeptidase
Glycosyl-hydrolase 97 C-terminal oligomerisation
RND efflux pump membrane fusion protein barrel-sandwich
Release factor glutamine methyltransferase N-terminal
Chemotaxis methyl-accepting receptor HlyB-like 4HB MCP
Putative auto-transporter adhesin head GIN
Putative auto-transporter adhesin head GIN domain-containing protein
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Cation-transporting P-type ATPase C-terminal
Cation-transporting P-type ATPase N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Threonine/serine exporter-like N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Aminoacyl-transfer RNA synthetases class-II family profile
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Starch-binding associating with outer membrane
Carboxypeptidase-like regulatory domain-containing protein
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
TonB-dependent receptor-like beta-barrel
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Polysaccharide chain length determinant N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Thiosulphate:quinone oxidoreductase small subunit DoxA
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Lipocalin-like domain-containing protein
Survival protein SurE-like phosphatase/nucleotidase
Peptidase S9 prolyl oligopeptidase catalytic
Glyoxalase/fosfomycin resistance/dioxygenase
O-(3'-phospho-DNA)-tyrosine intermediate
Glycoamylase-like domain-containing protein
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Polysaccharide biosynthesis protein CapD-like
Glycosyltransferase subfamily 4-like N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Large ribosomal subunit protein uL2 C-terminal
Outer membrane protein beta-barrel domain-containing protein
Cell wall-active antibiotics response LiaF-like C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Glycosyl hydrolase family 95 N-terminal domain-containing protein
NADH:ubiquinone oxidoreductase 30kDa subunit
Plays an important role in maintaining the position of the catalytic nucleophile
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
L,D-transpeptidase catalytic domain-containing protein
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Heavy metal binding domain-containing protein
Pseudouridine synthase I TruA alpha/beta
Endoribonuclease L-PSP/chorismate mutase-like
Tryptophan synthase beta chain-like PALP
Phosphatidic acid phosphatase type 2/haloperoxidase
Sulfatase-modifying factor enzyme domain-containing protein
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Signal transduction histidine kinase internal region
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Secretion system C-terminal sorting domain-containing protein
Glycosyl hydrolase family 30 beta sandwich
Contractile injection system tube protein N-terminal
Bacterial type II secretion system protein E
6-hydroxymethylpterin diphosphokinase MptE-like
DNA replication/recombination mediator RecO N-terminal
Major facilitator superfamily (MFS) profile
ATP-dependent exodnase (Exonuclease V) alpha subunit-helicase superfamily I member
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
Peptide methionine sulfoxide reductase MsrA
Peptide methionine sulphoxide reductase MsrA
Plays an important role in substrate specificity
Peptidase M43 pregnancy-associated plasma-A
Outer membrane lipoprotein BamD-like domain-containing protein
Curli production assembly/transport component CsgG
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Penicillin-binding protein transpeptidase
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
RNA 2-O ribose methyltransferase substrate binding
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Heme-copper oxidase subunit III family profile
DNA topoisomerase I catalytic core eukaryotic-type
Bacterial bifunctional deaminase-reductase C-terminal
Polymerase/histidinol phosphatase N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Signal transduction histidine kinase subgroup 2 dimerisation and phosphoacceptor
Prokaryotic-type class I peptide chain release factors
Transition state stabilizer; via amide nitrogen
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Glycosyl hydrolase-like 10 domain-containing protein
Cationic amino acid transporter C-terminal
Outer membrane lipoprotein-sorting protein
Beta-hexosaminidase bacterial type N-terminal
Ribosome maturation factor RimP N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Alpha galactosidase C-terminal beta sandwich
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
NAD(P) transhydrogenase alpha subunit C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Ribonucleotide reductase large subunit C-terminal
Alginate export domain-containing protein
Alanyl-transfer RNA synthetases family profile
Nitrite/Sulfite reductase ferredoxin-like
Membrane fusion protein biotin-lipoyl like
Putative glycogen debranching enzyme N-terminal
Thymidylate synthase/dCMP hydroxymethylase
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Prepilin type IV endopeptidase peptidase
Plays an important role in discriminating NADH against NADPH
Outer membrane protein/protective antigen OMA87
Type I restriction modification DNA specificity
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Large ribosomal subunit protein uL6 alpha-beta
NADH-rubredoxin oxidoreductase C-terminal
Glycoside hydrolase family 38 N-terminal
Positions MEP for the nucleophilic attack
Bacterial transcription activator effector binding
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Acetylserotonin O-methyltransferase dimerisation
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal
NADH:ubiquinone/plastoquinone oxidoreductase chloroplast chain 5 C-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Large ribosomal subunit protein uL30-like ferredoxin-like fold
SUF system FeS cluster assembly SufBD N-terminal
Translation elongation factor P/YeiP central
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Large ribosomal subunit protein bL9 C-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Insecticide toxin TcdB middle/N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
PhoD-like phosphatase metallophosphatase
Anthranilate synthase component I N-terminal
Ysc84 actin-binding domain-containing protein
Periplasmic component of the Tol biopolymer transport system
Neutral/alkaline non-lysosomal ceramidase N-terminal
Sialate O-acetylesterase domain-containing protein
Glycoside hydrolase family 65 C-terminal
Glycosyl transferase family 3 N-terminal
Electron transfer via tryptophanyl radical
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Beta-lactamase class A catalytic domain-containing protein
Calcineurin-like phosphoesterase C-terminal
Calcineurin-like phosphoesterase N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Cysteine sulfenic acid (-SOH) intermediate
Susd and RagB outer membrane lipoprotein
Small ribosomal subunit protein uS4 N-terminal
ABC-type uncharacterised transport system
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Chitobiase/beta-hexosaminidases N-terminal
Gliding motility-associated protein GldM C-terminal
Gliding motility-associated protein GldM N-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Gliding motility-associated C-terminal domain-containing protein
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Aspartate/homoserine dehydrogenase NAD-binding
Pyruvate phosphate dikinase AMP/ATP-binding
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Secretin/TonB short N-terminal domain-containing protein
Conserved virulence factor B-like winged helix
Molybdopterin cofactor biosynthesis C (MoaC)
Haem-binding uptake Tiki superfamily ChaN
Large ribosomal subunit protein uL15/eL18
Phosphomannose isomerase type I catalytic
Beta-lactamase-inhibitor-like PepSY-like domain-containing protein
Important for interaction with partner proteins
T9SS C-terminal target domain-containing protein
Membrane insertase YidC/Oxa/ALB C-terminal
Right handed beta helix domain-containing protein
Helix-hairpin-helix DNA-binding motif class 1
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Carboxypeptidase regulatory-like domain-containing protein
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glycine cleavage T-protein C-terminal barrel
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Polysaccharide biosynthesis protein C-terminal
Carbohydrate-binding domain-containing protein
NIF system FeS cluster assembly NifU N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
RNA binding; important for wobble base 34 recognition
DNA mismatch repair proteins mutS family
Trigger factor ribosome-binding bacterial
Type IX secretion system protein PorV domain-containing protein
BAAT/Acyl-CoA thioester hydrolase C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Gly-cisPro motif, important for rejection of L-amino acids
Proton acceptor; for glutaminase activity
Shikimate dehydrogenase substrate binding N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Probable endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
NIF system FeS cluster assembly NifU C-terminal
AMP-activated protein kinase glycogen-binding
Periplasmic copper-binding protein NosD beta helix
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Nicotinamide phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Chromosomal replication initiator DnaA C-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Inward rectifier potassium channel C-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Biopterin-dependent aromatic amino acid hydroxylase family profile
Reversibly protonated during proton transport
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Anti-bacteriophage protein A/HamA C-terminal
Type I restriction enzyme R protein N-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Urease accessory protein UreH-like transmembrane
Organic solvent tolerance-like N-terminal
Organic solvent tolerance-like N-terminal domain-containing protein
Resolvase/invertase-type recombinase catalytic
Restriction system protein Mrr-like N-terminal
Translation elongation factor EFTs/EF1B dimerisation