Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Peptidase S9 prolyl oligopeptidase catalytic
TRAP C4-dicarboxylate transport system permease DctM subunit
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Heat-inducible transcription repressor HrcA C-terminal
6-phosphogluconate dehydrogenase C-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
L,D-transpeptidase catalytic domain-containing protein
Superoxide dismutase copper/zinc binding
Alpha-glycerophosphate oxidase C-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Methionyl-tRNA synthetase anticodon-binding
DNA replication/recombination mediator RecO N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
RNA polymerase sigma factor 70 region 4 type 2
PhoD-like phosphatase metallophosphatase
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
PsrA tetracyclin repressor-like C-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Glycosyl transferase family 3 N-terminal
Threonine/serine exporter-like N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Peptidase C39-like domain-containing protein
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
YbaK/aminoacyl-tRNA synthetase-associated
Major facilitator superfamily (MFS) profile
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Polymerase/histidinol phosphatase N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Pyridoxamine 5'-phosphate oxidase putative
Peptidase S1A alpha-lytic prodomain domain-containing protein
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
6-phosphogluconate dehydrogenase NADP-binding
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Gram-positive cocci surface proteins LPxTG domain-containing protein
Anti-sigma-D factor RsdA sigma factor binding region
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Putative glycogen debranching enzyme N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Chromosomal replication initiator DnaA C-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Beta-hexosaminidase bacterial type N-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Tryptophan synthase beta chain-like PALP
FAD-dependent oxidoreductase 2 FAD binding
Important for beta-aspartyl-AMP intermediate formation
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Cytochrome C biogenesis protein transmembrane
Essential for prephenate dehydratase activity
Septum formation-related domain-containing protein
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Beta-xylosidase C-terminal Concanavalin A-like
Neutral/alkaline non-lysosomal ceramidase C-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Nicotinate phosphoribosyltransferase N-terminal
Erythromycin biosynthesis protein CIII-like central
Gly-cisPro motif, important for rejection of L-amino acids
RNA 2-O ribose methyltransferase substrate binding
Putative regulatory protein FmdB Zinc ribbon
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Bacterial bifunctional deaminase-reductase C-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Na+/H+ antiporter MnhB subunit-related protein
Removed in mature form; by autocatalysis
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
S-adenosyl-L-homocysteine hydrolase NAD binding
Prokaryotic-type class I peptide chain release factors
Phosphoribosylformylglycinamidine synthase linker
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Helix-hairpin-helix DNA-binding motif class 1
Phosphatidic acid phosphatase type 2/haloperoxidase
Large ribosomal subunit protein uL15/eL18
Carbamoyl-phosphate synthase small subunit N-terminal
Histidine-specific methyltransferase SAM-dependent
PLD phosphodiesterase domain-containing protein
Cell wall-active antibiotics response LiaF-like C-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Phosphocysteine intermediate; for EIIB activity
Prepilin type IV endopeptidase peptidase
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
SGNH hydrolase-type esterase domain-containing protein
ABC-type glycine betaine transport system substrate-binding
O-(5'-phospho-DNA)-tyrosine intermediate
Bacterial type II secretion system protein E
DNA primase/polymerase bifunctional N-terminal
Glycosyltransferase family 28 N-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Ribose-phosphate pyrophosphokinase N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Endoribonuclease L-PSP/chorismate mutase-like
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Glucose-methanol-choline oxidoreductase N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Pyrimidine nucleoside phosphorylase C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Resolvase/invertase-type recombinase catalytic
Polysaccharide biosynthesis protein CapD-like
Glycine cleavage T-protein C-terminal barrel
Release factor glutamine methyltransferase N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
NAD(P) transhydrogenase alpha subunit C-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Glucose-methanol-choline oxidoreductase C-terminal
Sporulation transcription regulator WhiA N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Homogentisate 1,2-dioxygenase C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Penicillin-binding protein transpeptidase
Large ribosomal subunit protein uL30-like ferredoxin-like fold
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
Myo-inositol-1-phosphate synthase GAPDH-like
Sodium/calcium exchanger membrane region
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Mycothiol-dependent maleylpyruvate isomerase metal-binding
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
Prealbumin-like fold domain-containing protein
Heme-copper oxidase subunit III family profile
Transcription regulator AsnC/Lrp ligand binding
ATP synthase F1 complex delta/epsilon subunit N-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Lactate utilization protein B C-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Cell envelope-related transcriptional attenuator
Large ribosomal subunit protein uL6 alpha-beta
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Glycoside-hydrolase family GH114 TIM-barrel
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Translation elongation factor P/YeiP central
Ribosomal RNA adenine methylase transferase N-terminal
Transglycosylase SLT domain-containing protein
Phosphotransferase system enzyme I N-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Alpha-D-phosphohexomutase alpha/beta/alpha
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Peptide methionine sulphoxide reductase MsrA
DNA-directed DNA polymerase family A palm
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Inosine/uridine-preferring nucleoside hydrolase
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Putative Flp pilus-assembly TadG-like N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Peptidase M1 membrane alanine aminopeptidase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Actinobacteria/chloroflexi VLRF1 release factor
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Phosphomannose isomerase type I catalytic
Cation-transporting P-type ATPase N-terminal
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
LamG-like jellyroll fold domain-containing protein
Glucosamine/galactosamine-6-phosphate isomerase
Protein O-mannosyl-transferase C-terminal four TM
Pyruvate dehydrogenase E1 component middle
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
ABC transporter substrate-binding protein PnrA-like
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Reversibly protonated during proton transport
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Schiff-base intermediate with D-ribose 5-phosphate
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
NIF system FeS cluster assembly NifU N-terminal
Exonuclease VII large subunit C-terminal
Endonuclease/exonuclease/phosphatase domain-containing protein
Anthranilate synthase component I N-terminal
Cytochrome bc1 complex Rieske iron-sulfur subunit
Large ribosomal subunit protein uL2 C-terminal
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Involved in ionization of N3 of dUMP, leading to its activation
Peptidoglycan recognition protein family
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Gram-positive cocci surface proteins LPxTG
Cytochrome oxidase subunit II copper A binding
Adaptive response protein AidB N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Gamma-glutamylcyclotransferase AIG2-like
Nitrite/Sulfite reductase ferredoxin-like
L-seryl-tRNA selenium transferase N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Putative oxidoreductase/dehydrogenase Rossmann-like
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Glutathionylspermidine synthase pre-ATP-grasp-like
Plays an important role in substrate specificity
Alanyl-transfer RNA synthetases family profile
Small ribosomal subunit protein uS4 N-terminal