SMODS-associating 2TM beta-strand rich effector
Activator of Hsp90 ATPase homologue 1-like C-terminal
Important for substrate binding and specificity
Flagellar basal body rod protein N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
Large ribosomal subunit protein uL15/eL18
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Na+/H+ antiporter MnhB subunit-related protein
Aminoacyl-transfer RNA synthetases class-II family profile
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase C-terminal
Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Alanyl-transfer RNA synthetases family profile
Major facilitator superfamily (MFS) profile
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Ysc84 actin-binding domain-containing protein
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Nicotinamide phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Glucose-methanol-choline oxidoreductase N-terminal
Bacterial type II secretion system protein E
Endolytic peptidoglycan transglycosylase RlpA
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Cytochrome c-type biogenesis protein CcmF C-terminal
TonB-dependent receptor-like beta-barrel
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Disulphide bond isomerase DsbC/G N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Signal transduction histidine kinase internal region
Peptidase S9 prolyl oligopeptidase catalytic
Mannose-6-phosphate isomerase type II C-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Alpha-D-phosphohexomutase alpha/beta/alpha
Threonine/serine exporter-like N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
NIF system FeS cluster assembly NifU C-terminal
6-phosphogluconate dehydrogenase C-terminal
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Anthranilate synthase component I N-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Peptide methionine sulphoxide reductase MsrA
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Phosphatidylglycerol lysyltransferase C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Calcium-dependent phosphoinositide phospholipase C
Interacts with tRNA; defines subfamily-specific binding signature
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Phosphoadenosine phosphosulphate reductase
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Late embryogenesis abundant protein LEA-2 subgroup
Late embryogenesis abundant protein LEA-2 subgroup domain-containing protein
Important for beta-aspartyl-AMP intermediate formation
Type 4 fimbrial biogenesis protein PilX N-terminal
Cob(I)alamin adenosyltransferase N-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Plays an important role in discriminating NADH against NADPH
Ribosomal RNA adenine methylase transferase N-terminal
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Lytic transglycosylase superhelical linker
Tryptophan synthase beta chain-like PALP
Chromosomal replication initiator protein DnaA
Arabinogalactan endo-beta-1,4-galactanase
Putative regulatory protein FmdB Zinc ribbon
Translation elongation factor P/YeiP central
Glycosyltransferase subfamily 4-like N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Glycosyl transferase family 3 N-terminal
Cytochrome C biogenesis protein transmembrane
Thiol:disulfide interchange protein DsbD N-terminal
Plays an important role in substrate specificity
Antitoxin Xre/MbcA/ParS-like toxin-binding
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Prokaryotic-type class I peptide chain release factors
Flagellar basal-body/hook protein C-terminal
Thiol:disulfide interchange protein DsbA
Translocation and assembly module subunit TamA
Cysteine sulfenic acid (-SOH) intermediate
Penicillin-binding protein transpeptidase
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Type IV secretion system coupling protein TraD DNA-binding
O-(5'-phospho-DNA)-tyrosine intermediate
DNA replication/recombination mediator RecO N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Flagellar motor switch protein FliN-like C-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Meiotically up-regulated gene 157 protein
Phage terminase large subunit GpA ATPase
Terminase large subunit GpA endonuclease
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Outer membrane protein beta-barrel domain-containing protein
Cytochrome b561 bacterial/Ni-hydrogenase
Large ribosomal subunit protein uL2 C-terminal
S-adenosylmethionine-dependent methyltransferase
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Superoxide dismutase copper/zinc binding
Prepilin type IV endopeptidase peptidase
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Polypeptide-transport-associated ShlB-type
Type II secretion system protein GspI C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Beta-lactamase hydrolase-like protein phosphatase-like
Gfo/Idh/MocA-like oxidoreductase N-terminal
Polymerase/histidinol phosphatase N-terminal
Chromosomal replication initiator DnaA C-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Bacteriophage T7 Gp4 DNA primase/helicase N-terminal
Calcium/calmodulin-dependent protein kinase II association-domain
Calcium/calmodulin-dependent protein kinase II association-domain domain-containing protein
RNA polymerase sigma factor 70 region 4 type 2
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
Aspartate/homoserine dehydrogenase NAD-binding
Interaction with polymerase core subunit RpoC
Pseudouridine synthase I TruA alpha/beta
Flagella basal body P-ring formation protein FlgA
Aromatic amino acid beta-eliminating lyase/threonine aldolase
3-beta hydroxysteroid dehydrogenase/isomerase
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Phosphoethanolamine transferase N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
Calcineurin-like phosphoesterase C-terminal
Glycosyl transferase family 28 C-terminal
Outer membrane protein assembly factor BamB
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
General stress protein FMN-binding split barrel
YbaK/aminoacyl-tRNA synthetase-associated
RNA binding; important for wobble base 34 recognition
Glutathionylspermidine synthase pre-ATP-grasp-like
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Histidine-specific methyltransferase SAM-dependent
ABC-type transport auxiliary lipoprotein component
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
NADH:ubiquinone oxidoreductase 30kDa subunit
Outer membrane protein assembly factor BamD
Nitrite/Sulfite reductase ferredoxin-like
Replication initiation protein-like C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Biopterin-dependent aromatic amino acid hydroxylase family profile
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
TonB C-terminal domain-containing protein
UDP N-acetylglucosamine O-acyltransferase C-terminal
Reversibly protonated during proton transport
S-adenosyl-L-homocysteine hydrolase NAD binding
L,D-transpeptidase catalytic domain-containing protein
Molybdopterin cofactor biosynthesis C (MoaC)
Exonuclease VII large subunit C-terminal
Arginine decarboxylase C-terminal helical
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Type II secretion system protein GspE N-terminal
BREX system Lon protease-like BrxL N-terminal
Cyclophilin-like domain-containing protein
CobB/CobQ-like glutamine amidotransferase
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Toxin co-regulated pilus biosynthesis protein Q C-terminal
Toxin co-regulated pilus biosynthesis protein Q C-terminal domain-containing protein
Pyruvate dehydrogenase E1 component middle
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Key residue in conferring substrate specificity for N-acetyl-L-ornithine versus N-succinyl-L-ornithine
Thymidylate synthase/dCMP hydroxymethylase
Seems to be a necessary countercharge to the potassium cations
Flagellar assembly protein FliH/Type III secretion system HrpE
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Helix-hairpin-helix DNA-binding motif class 1
Rap1a immunity protein domain-containing protein
Peptidase M12B domain-containing protein
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Outer membrane protein assembly factor BamA
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Inosine/uridine-preferring nucleoside hydrolase
Peptidase M1 membrane alanine aminopeptidase
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Important for interaction with partner proteins
Carbamoyl-phosphate synthase small subunit N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Aconitase A/isopropylmalate dehydratase small subunit swivel
Polysaccharide biosynthesis protein CapD-like
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Acyl-CoA dehydrogenase C-terminal bacterial-type
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Glycoside hydrolase GH146 substrate-binding
DNA mismatch repair proteins mutS family
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-92)
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Heme-copper oxidase subunit III family profile
Bacteriophage tail tape measure C-terminal
Bacteriophage tail tape measure N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Type III secretion system flagellar brake protein YcgR PilZN
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Essential for prephenate dehydratase activity
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Lysidine-tRNA(Ile) synthetase C-terminal
Acyl-ester intermediate; for transpeptidase activity
Proton donor; for transglycosylase activity
DNA-directed DNA polymerase family A palm
RNA 2-O ribose methyltransferase substrate binding
Glucose-methanol-choline oxidoreductase C-terminal
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Integral membrane protein YccS N-terminal
Outer-membrane lipoprotein carrier protein
Glycine cleavage T-protein C-terminal barrel
Polysaccharide chain length determinant N-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Release factor glutamine methyltransferase N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
Gly-cisPro motif, important for rejection of L-amino acids
Nicotinate phosphoribosyltransferase N-terminal
Type I restriction modification DNA specificity
Lysozyme inhibitor LprI N-terminal domain-containing protein
Glycosyl-hydrolase 97 C-terminal oligomerisation
SUF system FeS cluster assembly SufBD N-terminal
Right handed beta helix domain-containing protein
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Type VI secretion system IcmF C-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Glycosyltransferase family 28 N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Survival protein SurE-like phosphatase/nucleotidase
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Could be important to modulate the pK values of the two catalytic cysteine residues
Small ribosomal subunit protein uS4 N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Phosphotransferase system enzyme I N-terminal
CagE TrbE VirB component of type IV transporter system central
Aminoacyl-tRNA synthetase class I anticodon-binding
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
TRAP C4-dicarboxylate transport system permease DctM subunit
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Large ribosomal subunit protein uL6 alpha-beta
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
PHA accumulation regulator DNA-binding N-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Thiol:disulfide interchange protein DsbD N-terminal domain-containing protein
Alpha-glycerophosphate oxidase C-terminal
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Trigger factor ribosome-binding bacterial
Pyruvate phosphate dikinase AMP/ATP-binding
Trimeric autotransporter adhesin YadA-like head
Trimeric autotransporter adhesin YadA-like stalk
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Electron transfer via tryptophanyl radical
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
O-(phosphoribosyl dephospho-coenzyme A)serine
Membrane fusion protein biotin-lipoyl like