G-protein coupled receptors family 1 profile
Alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Helical; Signal-anchor for type II membrane protein
Beta-galactoside alpha-2,6-sialyltransferase 2
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Targeting to endoplasmic reticulum membrane
NmrA-like family domain-containing protein 1
Ubiquitin carboxyl-terminal hydrolase 28
NADH:ubiquinone oxidoreductase 30kDa subunit
High mobility group nucleosome-binding domain-containing protein 3
Cysteinyl-selenocysteine (Cys-Sec); redox-active
Sulfatase N-terminal domain-containing protein
Acyl-CoA-binding domain-containing protein 5
Cysteine/serine-rich nuclear protein N-terminal
Inward rectifier potassium channel C-terminal
Potassium channel inwardly rectifying transmembrane
Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
Histone-binding protein RBBP4 N-terminal
Serine/threonine-protein phosphatase PP1-beta catalytic subunit
Pseudouridine synthase I TruA alpha/beta
Peptidase M1 membrane alanine aminopeptidase
Ubiquitin carboxyl-terminal hydrolase family 1 cysteine active-site
Cerebellar degeneration-related protein 2
Ionotropic glutamate receptor C-terminal
Ionotropic glutamate receptor L-glutamate and glycine-binding
Protein-L-isoaspartate O-methyltransferase domain-containing protein 1
Zinc finger Ran-binding domain-containing protein 2
Bicarbonate transporter-like transmembrane
Small ribosomal subunit protein mS23 conserved
Low-density lipoprotein receptor-related protein 8
Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal
O-linked (Xyl...) (glycosaminoglycan) serine
Transcription initiation factor TFIID subunit 12
Serine/threonine-protein kinase 4 18kDa subunit
Serine/threonine-protein kinase 4 37kDa subunit
NAD(P)(+)--arginine ADP-ribosyltransferase 2
Beta-hexosaminidase eukaryotic type N-terminal
Dual serine/threonine and tyrosine protein kinase
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3
Choloylglycine hydrolase/NAAA C-terminal
Serine/threonine specific protein phosphatases
G-protein coupled receptors family 2 profile 2
Coiled-coil domain-containing protein 80
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
tRNA-splicing endonuclease subunit Sen15
Protein N-terminal glutamine amidohydrolase alpha beta roll
Increases binding of hyaluronan and heparin.
Interphotoreceptor matrix proteoglycan 1
No effect on binding of hyaluronan or heparin.
Reduces binding of hyaluronan and heparin.
Leucine-rich repeat transmembrane protein FLRT3
U4/U6 small nuclear ribonucleoprotein Prp3
Peptidase S9 prolyl oligopeptidase catalytic
Interchain (between light and heavy chains)
Cyclic nucleotide-gated channel rod photoreceptor subunit alpha
Histone-lysine N-methyltransferase SETD1B
Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal
Receptor-type tyrosine-protein phosphatase U
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
Acylamino-acid-releasing enzyme N-terminal
N-fatty-acyl-amino acid synthase/hydrolase PM20D1
VTT domain; required for its function in autophagy
Major facilitator superfamily (MFS) profile
NPC intracellular cholesterol transporter 2
Helical; Anchor for type IV membrane protein
Regulator of G-protein signaling 9-binding protein
CCR4-NOT transcription complex subunit 10
Cytokine-inducible SH2-containing protein
Necessary for transcriptional repression
von Hippel-Lindau disease tumour suppressor alpha
von Hippel-Lindau disease tumour suppressor beta
Hydroxyacylglutathione hydrolase-like protein
Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate
Schiff-base intermediate with dihydroxyacetone-P
Voltage-gated Na+ ion channel cytoplasmic
RNA 3'-terminal phosphate cyclase insert
Ligand-dependent nuclear receptor corepressor-like protein
O-linked (Xyl...) (chondroitin sulfate) serine
Proto-oncogene tyrosine-protein kinase Yrk
Ubiquitin-like modifier-activating enzyme ATG7
Prokaryotic-type class I peptide chain release factors
Rapamycin-insensitive companion of mTOR N-terminal
Rapamycin-insensitive companion of mTOR middle
Cysteine sulfinic acid (-SO2H); alternate
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central
Uncharacterized protein KIAA1671 homolog
Zinc finger CCCH domain-containing protein 11A
Interaction with Type I keratins and keratin filaments
His-rich loop; required for zinc transport
U2A'/phosphoprotein 32 family A C-terminal
Protein-arginine deiminase (PAD) N-terminal
Protein-arginine deiminase (PAD) central
Serine/arginine repetitive matrix protein 1
N-linked (GlcNAc...) (keratan sulfate) asparagine
cAMP-dependent protein kinase type I-alpha regulatory subunit
3-beta hydroxysteroid dehydrogenase/isomerase
Abolishes sulfate transport. Does not affect oxalate transport. Is accesible both from extracellular and intracellular side by methane-thiosulphonate (MTS) reagents. Inhibits divalent transport upon extracellular application of (2-sulphonatoethyl)methane-thiosulphonate (MTSES) but not [2-(trimethylammonium)ethyl]methane-thiosulphonate (MTSET). Abolishes anion transport upon intracellular MTSET application.
Transforming growth factor beta activator LRRC32
Bone morphogenetic protein receptor type-1B
Loss of positive regulation of chondrocyte differentiation.
Strongly decreases positive regulation of chondrocyte differentiation.
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
1-acyl-sn-glycerol-3-phosphate acyltransferase
Does not significantly affect biophysicochemical properties.
Hydroxymethylglutaryl-CoA synthase, cytoplasmic
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
Store-operated calcium entry-associated regulatory factor
Important for the catalytic mechanism; involved in substrate deprotonation
G-protein coupled receptors family 3 profile
Cation-transporting P-type ATPase N-terminal
Neurotransmitter-gated ion-channel ligand-binding
Neurotransmitter-gated ion-channel transmembrane
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members
Fibronectin type-III domain-containing protein 3a
Release factor glutamine methyltransferase N-terminal
Large ribosomal subunit protein uL4 C-terminal
Histone-lysine N-methyltransferase SUV39H2
Ubiquitin-like modifier-activating enzyme 5
Pleckstrin homology domain-containing family F member 2
Protein-glucosylgalactosylhydroxylysine glucosidase
ADP-ribosylasparagine; by botulinum toxin
Cleavage (when cotranslationally processed)
Membrane-associated progesterone receptor component 1
Coiled-coil domain-containing protein 50
Required for dimerization upon membrane association
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
G-protein coupled receptors family 2 profile 1
Serine-threonine kinase receptor-associated protein
Asparagine synthetase [glutamine-hydrolyzing]
Important for beta-aspartyl-AMP intermediate formation
RNA polymerase II subunit A C-terminal domain phosphatase SSU72
Lysosomal-associated transmembrane protein 4A
Fanconi anaemia group A protein N-terminal
Required for ubiquitin ligase activity and protection against ER stress-induced cell death
Breast cancer metastasis-suppressor 1-like protein
Required for the recognition of 25-hydroxycholesterol
Pyridine nucleotide-disulphide oxidoreductase N-terminal
Probable glutamate--tRNA ligase, mitochondrial
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Dual specificity mitogen-activated protein kinase kinase 2
Cytochrome b-c1 complex subunit Rieske, mitochondrial
Gamma tubulin complex component C-terminal
Gamma tubulin complex component protein N-terminal
Glyceraldehyde-3-phosphate dehydrogenase
Inhibitor of growth protein N-terminal histone-binding
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Heterochromatin protein 1-binding protein 3
General transcription factor IIH subunit 5
Abrogates interaction with HDAC2 and impairs transcriptional repression.
Abrogates interaction with RBBP4 and impairs transcriptional repression.
GTPase-activating Rap/Ran-GAP domain-like protein 3
Trafficking protein particle complex subunit 11
Pterin-4-alpha-carbinolamine dehydratase 2
Cilia- and flagella-associated protein 20
Abolishes interaction with SRCSH3 domain and decreases tyrosine phosphorylation.
Reduces phosphorylation and abolishes interaction with activated SRC; when associated with A-93; A-451 and A-453.
Reduces phosphorylation and abolishes interaction with activated SRC; when associated with A-93; A-94 and A-451.
Reduces phosphorylation and abolishes interaction with activated SRC; when associated with A-94; A-451 and A-453.
Interferon regulatory factor 2-binding protein 1 & 2 zinc finger
Pro-neuregulin-1, membrane-bound isoform
Phosphatidic acid phosphatase type 2/haloperoxidase
Actin, aortic smooth muscle, intermediate form
N-acetylglutamate; in Actin, aortic smooth muscle
Rad21/Rec8-like protein C-terminal eukaryotic
Transcription initiation factor TFIID subunit 8
DNA-directed RNA polymerase III subunit RPC1
Arylamine N-acetyltransferase, liver isozyme
Mast/stem cell growth factor receptor Kit
Guanine nucleotide-binding protein G(i) subunit alpha-1
Lysosome-associated membrane glycoprotein 1
Activating signal cointegrator 1 complex subunit 3
NF-kappa-B inhibitor-interacting Ras-like protein 2
Pleckstrin homology domain-containing family J member 1
Alpha-2-macroglobulin receptor-associated protein
Queuine tRNA-ribosyltransferase accessory subunit 2
G protein-activated inward rectifier potassium channel 1
Inhibits partially single-stranded DNA-binding activity but not homodimerization.
Aminoacyl-transfer RNA synthetases class-II family profile
Eukaryotic translation initiation factor 3 subunit J
Myosin regulatory light chain 2, smooth muscle minor isoform
Interacts with AURKB but fails to fully activate AURKB.
Tetratricopeptide repeat protein 7 N-terminal
Dramatic decrease in antimicrobial activity.
Potassium channel tetramerisation-type BTB
Ubiquitin-associated domain-containing protein 1
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Essential for DNA hairpin formation, participates in base-stacking interactions near the cleavage site
V(D)J recombination-activating protein 1
Heart- and neural crest derivatives-expressed protein 1
Mediator of RNA polymerase II transcription subunit 20
Trimethyllysine dioxygenase, mitochondrial
Arginine vasopressin-induced protein 1/transcriptional and immune response regulator
Mediator complex subunit Med13 C-terminal
Sister chromatid cohesion protein PDS5 homolog A
Cell surface glycoprotein CD200 receptor 1-A
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3
Leucine-rich repeat-containing protein 45
Alanyl-transfer RNA synthetases family profile
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Lethal mitotic defects; when associated with A-22 and A-75. Lethal mitotic defects; when associated with A-11; A-12; A-22; A-54 and A-56. Lethal mitotic defects; when associated with A-11; A-12; A-22 and A-75.
Lethal mitotic defects; when associated with A-7 and A-22. Lethal mitotic defects; when associated with A-7; A-11; A-12 and A-22.
Lethal mitotic defects; when associated with A-7 and A-75. Lethal mitotic defects; when associated with A-7; A-11; A-12; A-54 and A-56. Lethal mitotic defects; when associated with A-7; A-11; A-12 and A-75.
Lethal mitotic defects; when associated with A-7; A-11; A-12; A-22 and A-54.
Lethal mitotic defects; when associated with A-7; A-11; A-12; A-22; and A-56.
Lethal mitotic defects; when associated with A-7; A-11; A-22; A-54 and A-56. Lethal mitotic defects; when associated with A-7; A-11; A-22 and A-75.
Lethal mitotic defects; when associated with A-7; A-12; A-22; A-54 and A-56. Lethal mitotic defects; when associated with A-7; A-12; A-22 and A-75.
Origin recognition complex subunit 3 N-terminal
Origin recognition complex subunit 3 insertion
Origin recognition complex subunit 3 winged helix C-terminal
Activated RNA polymerase II transcriptional coactivator p15
Sufficient for interaction with the PRC2 complex
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Exocyst complex subunit Sec15 C-terminal
Transforming acidic coiled-coil-containing protein C-terminal
Interaction with the F-box domain of F-box proteins
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Asymmetric dimethylarginine; by CARM1; alternate
Asymmetric dimethylarginine; by PRMT6; alternate
N6-(2-hydroxyisobutyryl)lysine; alternate
Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5
Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5
Symmetric dimethylarginine; by PRMT5; alternate
Alpha-ketoglutarate-dependent dioxygenase FTO catalytic
Zinc finger CCCH domain-containing protein 14
Important for interaction with membranes
Phosphatidylinositol 4-kinase type 2-beta
DNA-dependent protein kinase catalytic subunit
RNA N6-adenosine-methyltransferase METTL16
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Vacuolar protein sorting-associated protein 29
Guanine nucleotide-binding protein G(i) subunit alpha-2
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
Hydroxysteroid 11-beta-dehydrogenase 1-like protein
5-glutamyl glycerylphosphorylethanolamine
Activity-regulated cytoskeleton-associated protein
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
Large ribosomal subunit protein uL6 N-terminal
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
Interaction with phosphoserine on interacting protein
Sodium/calcium exchanger membrane region
Transcription termination factor 3, mitochondrial
Exocyst complex component Sec3 PIP2-binding N-terminal
Neuronal acetylcholine receptor subunit alpha-9
Cyclic nucleotide phosphodiesterase catalytic
G2/M phase-specific E3 ubiquitin-protein ligase
Cleavage and polyadenylation specificity factor subunit 6
Interleukin-1 receptor accessory protein-like 1
Dual specificity tyrosine-phosphorylation-regulated kinase 2
Limbic system-associated membrane protein
Serine/threonine-protein phosphatase 6 regulatory subunit 3
Activator of Hsp90 ATPase AHSA1-like N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
N-end rule aminoacyl transferase C-terminal
Mediator of RNA polymerase II transcription subunit 22
Clathrin/coatomer adaptor adaptin-like N-terminal
Coatomer gamma subunit appendage Ig-like subdomain
26S proteasome non-ATPase regulatory subunit 13
Spermatid perinuclear RNA-binding protein
Synaptotagmin-like mitochondrial and lipid-binding
Transducer of regulated CREB activity C-terminal
Transducer of regulated CREB activity N-terminal
Transducer of regulated CREB activity middle
Choline/ethanolaminephosphotransferase 1
Sister chromatid cohesion protein PDS5 homolog B
Acidic leucine-rich nuclear phosphoprotein 32 family member B
Nuclear respiratory factor 1 NLS/DNA-binding dimerisation
Glucosamine/galactosamine-6-phosphate isomerase
Asparagine synthetase domain-containing protein 1
Protein phosphatase 1 regulatory subunit 12A
Reduces phosphorylation. Reduces phosphorylation on serine and threonine residues by 80%; when associated with A-695.
Reduces phosphorylation. Reduces phosphorylation on serine and threonine residues by 80%; when associated with A-850.
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Troponin T, fast skeletal muscle isoforms
43 kDa receptor-associated protein of the synapse
Low molecular weight phosphotyrosine protein phosphatase
Low-density lipoprotein receptor-related protein
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
Ribosomal RNA adenine methylase transferase N-terminal
Methyl-CpG binding protein 2/3 C-terminal
Biopterin-dependent aromatic amino acid hydroxylase family profile
Facilitates phospholipid membrane insertion
Greatly reduced phosphorylation levels in platelets. Little change in cell spreading. Complete loss of phosphorylation. No change in subcellular location nor on in vitro actin binding. 40% decrease in cell spreading; when associated with F-100.
No change of phosphorylation levels in platelets.
Phosphotyrosine; by SRC-type Tyr-kinases
Some reduction of phosphorylation levels in platelets. Little change in cell spreading. Complete loss of phosphorylation. No change in subcellular location nor on in vitro actin binding. 40% decrease in cell spreading; when associated with F-1134.
Basic motif; required for the activation of phospholipid synthesis
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Abolishes binding to OPTN; when associated with E-1088.
Abolishes binding to OPTN; when associated with E-1091.
Interaction with TAX1BP1 and CALCOCO2/NDP52
No effect on binding to OPTN; when associated with A-1088.
No effect on binding to OPTN; when associated with A-1091.
U3 small nucleolar RNA-associated protein 13 C-terminal
O-linked (Xyl...) (chondroitin sulfate) serine; alternate
O-linked (Xyl...) (heparan sulfate) serine; alternate
Alpha-ketoglutarate-dependent dioxygenase AlkB-like
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
Fails to bind PIK3R1 in a BCR-signaling dependent manner; when associated with Y-266; Y-423 and Y-448.
Fails to bind PIK3R1 in a BCR-signaling dependent manner; when associated with Y-266; Y-423 and Y-463.
Fails to bind PIK3R1 in a BCR-signaling dependent manner; when associated with Y-266; Y-448 and Y-463.
Fails to bind PIK3R1 in a BCR-signaling dependent manner; when associated with Y-423; Y-448 and Y-463.
Necessary and sufficient to mediate inhibition of NF-kappa-B downstream of activated TLRs
Phosphoinositide 3-kinase adapter protein 1
Ras-responsive element-binding protein 1
Probable cation-transporting ATPase 13A4
Necessary for binding to the m3G-cap structure
Tyrosine-protein phosphatase non-receptor type 1
Rho guanine nucleotide exchange factor 6
NAD(P)(+)--arginine ADP-ribosyltransferase
Increases channel conductance by almost 100%.
Key residue for a rapid dissociation (K(off)) from the conotoxin BuIA
Key residue that may interfere with effective access of the conotoxin BuIA to the channel binding site
Neuronal acetylcholine receptor subunit beta-2
Fanconi anemia core complex-associated protein 24 pseudonuclease
7-methylguanosine phosphate-specific 5'-nucleotidase
Actin, alpha cardiac muscle 1, intermediate form
N-acetylaspartate; in Actin, alpha cardiac muscle 1
Sodium channel modifier 1 acidic C-terminal
Inhibits translocation to the nucleus (Ten-1 ICD form).
Required for interaction with SORBS1 (Ten-1 ICD form)
Gamma-aminobutyric acid receptor subunit alpha-1
Ubiquitin carboxyl-terminal hydrolase BAP1
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
60 kDa heat shock protein, mitochondrial
receptor protein serine/threonine kinase
Vesicle tethering protein Uso1/P115-like head
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
Major facilitator superfamily domain-containing protein 1
Cell surface glycoprotein CD200 receptor 1-B
Cyclic AMP-dependent transcription factor ATF-2
Microtubule-associated protein 6 homolog
Reduced enzyme activity. Decreased Km values for ADP.
Reduced enzyme activity. Increased Km value for ATP, AMP and ADP. Km value for ThDP decreased to about one fifth of that of the wild-type enzyme.
Phosphorylase b kinase regulatory subunit alpha/beta C-terminal
Dipeptidyl peptidase 4 low complexity region
Endoplasmic reticulum vesicle transporter C-terminal
Endoplasmic reticulum vesicle transporter N-terminal
Fibroblast growth factor-binding protein 2
Cationic amino acid transporter C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
In isoform 6, isoform 7, isoform 8, isoform 9, isoform 10 and isoform 12.
Provides specificity for BDNF as ligand versus NTF3 and NTF4
Acetylserotonin O-methyltransferase dimerisation
Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog
Swi5-dependent recombination DNA repair protein 1 homolog
Alpha/beta hydrolase domain-containing protein 17B
Chromatin target of PRMT1 protein C-terminal
Xylosyl- and glucuronyltransferase LARGE1
Exocyst complex subunit Exo70 C-terminal
Platelet-derived growth factor (PDGF) family profile
Does not induce a strong decrease in its electrophoretic retardation.
Induces a strong decrease in its electrophoretic retardation.
Nuclear factor interleukin-3-regulated protein
Important for binding and subsequent lysosomal degradation of target proteins
Lysosome-associated membrane glycoprotein 2
Overexpressed in colon carcinoma 1 protein homolog
Lipid-binding serum glycoprotein C-terminal
Lipid-binding serum glycoprotein N-terminal
Involved in the interaction with the conotoxin GeXXA
Neuronal acetylcholine receptor subunit alpha-10
Decrease in phosphorylation and decrease in regulation of TJP1 binding. Loss of phosphorylation and loss of regulation of TJP1 binding; when associated with F-383.
Decrease in phosphorylation and loss of regulation of TJP1 binding. Loss of phosphorylation and loss of regulation of TJP1 binding; when associated with F-379.
Lower binding to TJP1 and TJP3, decrease in phosphorylation and loss of regulation of TJP1 and TJP3 binding. Lower binding to TJP1 and TJP3, loss of phosphorylation and loss of regulation of TJP1 binding; when associated with D-379.
Lower binding to TJP1, higher binding to TJP3 and decrease in phosphorylation. Lower binding to TJP1 and TJP3, loss of phosphorylation and loss of regulation of TJP1 binding; when associated with D-383.
E3 ubiquitin-protein ligase Arkadia N-terminal
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
Interaction with galactose moiety of substrate glycoprotein
Mothers against decapentaplegic homolog 3
Necessary for interaction with NCAM and myoblast protrusion formation
Rho family-interacting cell polarization regulator 2
Steroidogenic acute regulatory protein, mitochondrial
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Extracellular fatty acid-binding protein
Discoidin, CUB and LCCL domain-containing protein 2
Cyclic nucleotide-gated channel cone photoreceptor subunit alpha
Zinc finger CCCH domain-containing protein 15
Lysosomal cobalamin transport escort protein LMBD1
Steroid 17-alpha-hydroxylase/17,20 lyase
Anaphase-promoting complex subunit 4-like WD40
Necessary and sufficient to promote mitochondrial fission
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
Spectrin alpha chain, non-erythrocytic 1
Myristoylated alanine-rich C-kinase substrate
P2R1A-PPP2R2A-interacting phosphatase regulator 1
Sodium/hydrogen exchanger regulatory region
Eukaryotic translation initiation factor 3 subunit L
Regulation of nuclear pre-mRNA domain-containing protein 1A
Dehydrogenase/reductase SDR family member 11
Origin recognition complex subunit 5 C-terminal
Major intrinsically disordered Notch2-binding receptor 1-like C-terminal
Bifunctional purine biosynthesis protein ATIC
Proton acceptor; for AICAR formyltransferase activity
Proton donor/acceptor; for FAICAR cyclization activity
Hyaluronan and proteoglycan link protein 1
Important for cleavage of target proteins
Nucleolar and spindle-associated protein 1
Endothelial differentiation-related factor 1 homolog
Mitochondrial tRNA-specific 2-thiouridylase 1
Iron-responsive element-binding protein 2
Reversion-inducing cysteine-rich protein with Kazal motifs
WD repeat domain phosphoinositide-interacting protein 3
Proton acceptor; for glutaminase activity
Conserved oligomeric Golgi complex subunit 4
Neuronal acetylcholine receptor subunit alpha-2
Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
Probable ATP-dependent RNA helicase DDX10
Calcium-activated potassium channel BK alpha subunit
Calcium-activated potassium channel subunit alpha-1
Helical; Voltage-sensor; Name=Segment S4
Ubiquitin-associated domain-containing protein 2
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Neuronal acetylcholine receptor subunit alpha-4
Inhibitor of nuclear factor kappa-B kinase subunit alpha
Myoblast determination protein 1 homolog
Important for formation of active hexamer structure
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
Xylosyl- and glucuronyltransferase LARGE2s
Nucleoporin Nup133/Nup155-like C-terminal
Nucleoporin Nup133/Nup155-like N-terminal
T-cell-specific surface glycoprotein CD28 homolog
Elongation of very long chain fatty acids protein 6
POU domain, class 5, transcription factor 3
Voltage-gated potassium channel subunit beta-1
Ribitol-5-phosphate transferase FKTN N-terminal
Hydroxysteroid dehydrogenase-like protein 1
S-adenosyl-L-homocysteine hydrolase NAD binding
Carnitine O-palmitoyltransferase N-terminal
Microtubule-associated protein RP/EB family member 1
WLDD motif; essential for 7-methylguanosine-containing mRNA cap binding
Abrogates interaction with CHAF1B and HIRA.
Interaction with CHAF1B, HIRA, histone H3 and histone H4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
Disintegrin and metalloproteinase domain-containing protein 9
Does not reduce the actin-severing activity. Does not affect actin-capping activity.
Reduces the actin-severing activity. Does not affect actin-capping activity.
Myosin light chain 1, skeletal muscle isoform
Myosin light chain 3, skeletal muscle isoform
Lysosomal amino acid transporter 1 homolog
Loss of function; when associated with A-452.
Loss of function; when associated with A-578.
Deamidated asparagine; in forms C1, C2 and C3; partial
Deamidated glutamine; in forms C1 and C2; partial
Deamidated glutamine; in forms C1, C2 and C3; partial
Omega-N-methylarginine; in forms C1, C2 and C3; alternate
Symmetric dimethylarginine; in forms C1, C2 and C3; alternate
Gamma-aminobutyric acid receptor subunit alpha-6
Arylamine N-acetyltransferase, pineal gland isozyme NAT-3
GATOR complex protein MIO zinc-ribbon like
Cytoplasmic activation/proliferation-associated protein-1 C term
Ciliary neurotrophic factor receptor subunit alpha
Nascent polypeptide-associated complex subunit alpha-like UBA
Gamma-butyrobetaine hydroxylase-like N-terminal
Trifunctional purine biosynthetic protein adenosine-3
ADP-ribosylation factor-like protein 2-binding protein
KH domain-containing RNA-binding protein QKI
Oligosaccharyltransferase complex subunit OSTC
Required for endocytosis and down-regulation
WAP four-disulfide core domain protein 1
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Acidic leucine-rich nuclear phosphoprotein 32 family member E
Cysteine and histidine-rich domain-containing protein 1
26S proteasome non-ATPase regulatory subunit RPN1 C-terminal
NEDD8-activating enzyme E1 regulatory subunit
In isoform Alpha-KD and isoform Beta-KD.
Alkaline phosphatase, tissue-nonspecific isozyme
Eukaryotic translation initiation factor 5A-2
Translation elongation factor IF5A C-terminal
Thiazolidine linkage to a ring-opened DNA abasic site
Trafficking protein particle complex subunit 2
Glycine dehydrogenase (decarboxylating), mitochondrial
DNA-directed RNA polymerase subunit 2 hybrid-binding
Alpha/beta hydrolase domain-containing protein 17C
WD repeat domain phosphoinositide-interacting protein 2
T-cell surface glycoprotein CD8 alpha chain
Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
tRNA (guanine(10)-N2)-methyltransferase homolog
Pyrroline-5-carboxylate reductase catalytic N-terminal
Katanin p80 WD40 repeat-containing subunit B1
Type I cytokine receptor cytokine-binding
Cytoskeleton-associated protein 2 C-terminal
Phosphoinositide 3-kinase regulatory subunit 5
Eukaryotic translation initiation factor 2 subunit 1
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Tyrosine-protein phosphatase non-receptor type 11
Transmembrane anterior posterior transformation protein 1 homolog
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
NAD(P)(+)--arginine ADP-ribosyltransferase 1
Abolishes cleavage of C-terminal propeptide.
Abolishes secretion of processed zona pellucida sperm-binding protein 3.
Abolishes secretion of processed zona pellucida sperm-binding protein 3; when associated with A-111.
Abolishes secretion of processed zona pellucida sperm-binding protein 3; when associated with A-152.
Abolishes secretion of processed zona pellucida sperm-binding protein 3; when associated with A-251.
Abolishes secretion of processed zona pellucida sperm-binding protein 3; when associated with A-313.
Abolishes secretion of processed zona pellucida sperm-binding protein 3; when associated with A-332.
Abolishes secretion of processed zona pellucida sperm-binding protein 3; when associated with A-334.
Abolishes secretion of processed zona pellucida sperm-binding protein 3; when associated with A-335.
Abolishes secretion of processed zona pellucida sperm-binding protein 3; when associated with A-340.
Abolishes secretion of processed zona pellucida sperm-binding protein 3; when associated with A-58.
Abolishes secretion of processed zona pellucida sperm-binding protein 3; when associated with A-90.
Impaired homodimerization and abolished secretion of processed zona pellucida sperm-binding protein 3.
Impaired secretion of processed zona pellucida sperm-binding protein 3; when associated with A-229.
Impaired secretion of processed zona pellucida sperm-binding protein 3; when associated with A-295.
Loss of O-glycosylation. No effect on secretion. Reduces binding to the sperm head by about 80%.
Processed zona pellucida sperm-binding protein 3
Hypoxanthine-guanine phosphoribosyltransferase
Fine-tunes the proton-transfer properties of H-64
5-aminolevulinate synthase, non-specific, mitochondrial
Asymmetric dimethylarginine; by PRMT1; alternate
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate
Omega-N-methylarginine; by PRMT1; alternate
Symmetric dimethylarginine; by PRMT5 and PRMT7; alternate
Loss of function in DNA repair; when associated with W-171.
Loss of function in DNA repair; when associated with Y-63.
Mitotic spindle assembly checkpoint protein MAD2B
Activating transcription factor 7-interacting protein 1
G-protein coupled receptor-associated protein LMBRD2
Suppressor of tumorigenicity 7 protein homolog
KH domain-containing, RNA-binding, signal transduction-associated protein 1
3' overhang DNA-binding; via amide nitrogen
Necessary for dimerization and homooligomerization
Necessary for ssDNA and DNA Holliday junction binding
Signal recognition particle SRP72 subunit RNA-binding
Ubiquitin carboxyl-terminal hydrolase 10
Reduces SLC9A1/NHE1 stability and Na(+)/H(+) exchange activities; when associated with A-134.
Reduces SLC9A1/NHE1 stability and Na(+)/H(+) exchange activities; when associated with A-175.
Reduces SLC9A1/NHE1 stability. Does not reduce Na(+)/H(+) SLC9A1/NHE1 exchange activities.
Vacuolar ATPase assembly integral membrane protein VMA21
Cyclic dinucleotide-binding domain (CBD)
Could be involved in the assembly of the multisynthetase complex
Nuclear nucleic acid-binding protein C1D
Phosphoribosyl pyrophosphate synthase-associated protein 2
Cysteine sulfonic acid (-SO3H); alternate
Impairs binding to distorted DNA; when associated with A-12.
Impairs binding to distorted DNA; when associated with A-3.
Involved in intramolecular interaction with K-3
Involved in intramolecular interaction with the C-terminal acidic tail
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Decrease in E3 ligase activity. Complete loss of myoblast growth suppression activity; when associated with A-260.
Decrease in E3 ligase activity. Loss of myoblast growth suppression activity.
Decrease in E3 ligase activity. Loss of myoblast growth suppression activity; when associated with A-258.
BAG family molecular chaperone regulator 5
10 X 8 AA approximate tandem repeats of P-[TS]-P-S-P-[QA]-[SG]-Y, motif CTR2
9 X 7 AA approximate tandem repeats of G-S-[QR]-T-P-X-[YQ], motif CTR1
Neuronal acetylcholine receptor subunit alpha-3
Almost complete loss of YRNA binding. About 80-fold decrease in affinity for binding to ACTB transcript, but almost no effect on MYC transcript binding; when associated with 505-E-E-506. Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2, almost complete loss of ACTB and MYC transcript binding, almost complete loss of ELAVL1-, DHX9- and HNRNPU-binding and accumulation in the nucleus; when associated with E-213, E-294 and 505-E-E-506.
Decrease in YRNA binding. About 80-fold decrease in affinity for binding to ACTB transcript, but almost no effect on MYC transcript binding; when associated with 422-E-E-423. Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2, almost complete loss of ACTB and MYC transcript binding, almost complete loss of ELAVL1-, DHX9- and HNRNPU-binding and accumulation in the nucleus; when associated with E-213, E-294 and 422-E-E-423.
Decrease in YRNA binding. Only small decrease in affinity for binding to ACTB and MYC transcripts, some accumulation in the nucleus, and complete loss of formation of higher ordered protein-RNA complexes; when associated with E-213. Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2, almost complete loss of ACTB and MYC transcript binding, almost complete loss of ELAVL1-, DHX9- and HNRNPU-binding and accumulation in the nucleus; when associated with E-213, 422-E-E-423 and 505-E-E-506.
Decrease in YRNA binding. Only small decrease in affinity for binding to ACTB and MYC transcripts, some accumulation in the nucleus, and complete loss of formation of higher ordered protein-RNA complexes; when associated with E-294. Loss of homo- and heterooligomerization with IGF2BP1 and IGF2BP2, almost complete loss of ACTB and MYC transcript binding, almost complete loss of ELAVL1-, DHX9- and HNRNPU-binding and perturbed subcellular location, including accumulation in the nucleus and loss of localization to stress granules; when associated with E-294, 422-E-E-423 and 505-E-E-506.
Impairs the interaction with beta-actin mRNA and its translation repression.
Increases the interaction with ACTB mRNA and its translational repression.
Insulin-like growth factor 2 mRNA-binding protein 1
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
8 X 6 AA tandem repeats of [HR]-[NQ]-P-G-Y-P
Cytoplasmic dynein 1 light intermediate chain 1
Trafficking protein particle complex subunit 3
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
CCR4-NOT transcription complex subunit 7
Nuclear envelope integral membrane protein 2
Calcium/calmodulin-dependent protein kinase type II delta chain
Abolishes homodimerization and cell-cell adhesion; when associated with A-272.
Abolishes homodimerization and cell-cell adhesion; when associated with A-273.
Voltage-dependent calcium channel alpha-1 subunit IQ
Phosphatidylcholine:ceramide cholinephosphotransferase 1
Electron transfer via tryptophanyl radical
Epithelial splicing regulatory protein 2
Uracil phosphoribosyltransferase homolog
Dynamin-like 120 kDa protein, mitochondrial
Ankyrin repeat and MYND domain-containing protein 2
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
Vitamin D3 hydroxylase-associated protein
Ran-GTPase activating protein 1 C-terminal
Important for autoinhibition of adenylyltransferase activity
Required for binding 2'-O-methylated 3'-end of piRNAs
Mitochondrial proton/calcium exchanger protein
Mediator of RNA polymerase II transcription subunit 24
Eukaryotic translation initiation factor 3 subunit M
Required for heterodimerization with the heparanase 8 kDa subunit
Required for transferring proheparanase to the Golgi apparatus, secretion and subsequent enzyme activity and for enhancement of PKB/AKT1 phosphorylation
Telomerase activating protein Est1-like N-terminal
TATA-binding protein interacting (TIP20)
Riboflavin-binding protein, yolk major form
Riboflavin-binding protein, yolk minor form
Insulin-like growth factor 2 mRNA-binding protein 3
Tumor necrosis factor alpha-induced protein 8
Fibronectin type-III domain-containing protein
Glycosyl hydrolases family 2 sugar binding
S-adenosylmethionine sensor upstream of mTORC1
Myosin regulatory light chain 2, smooth muscle major isoform
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Nuclear receptor subfamily 2 group E member 1
Transcription factor TFIIIC triple barrel
SUEL-type lectin domain-containing protein
Granulocyte-macrophage colony-stimulating factor
Decreases interaction with SMARCA2 and MED23.
Decreases methylation by CARM1 and increases transactivation activity.
Decreases methylation. Increases transactivation activity inhibition.
Not methylated. Increases interaction with SMARCA2 and MED23.
Phosphothreonine; by RPS6KA1, CDK2 and MAPK
TATA box-binding protein-associated factor RNA polymerase I subunit B
RecQ-mediated genome instability protein 1
Actin, cytoplasmic 2, N-terminally processed
N-acetylglutamate; in Actin, cytoplasmic 2, N-terminally processed
N-acetylmethionine; in Actin, cytoplasmic 2; alternate
In Lmbr1-N; associated with preaxial polydactyly.
Pre-mRNA processing factor 4 (PRP4)-like
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Small ribosomal subunit protein uS4 N-terminal
Pleckstrin homology domain-containing family O member 1
Zinc finger and BTB domain-containing protein 14
Vacuolar protein sorting-associated protein 51 homolog
Alpha-D-phosphohexomutase alpha/beta/alpha
116 kDa U5 small nuclear ribonucleoprotein component
Does not affect activation by nicked DNA, while it prevents activation by a 3'-overhang substrate.
Protein mono-ADP-ribosyltransferase PARP3
Spindle assembly abnormal protein 6 homolog
tRNA N(3)-methylcytidine methyltransferase METTL2
Pyruvate dehydrogenase E1 component subunit alpha
Ornithine transcarbamylase, mitochondrial
RNA polymerase subunit H/Rpb5 C-terminal
Histone acetyl transferase HAT1 N-terminal
Important for recycling of cargo proteins with the sequence motif K-D-E-L from the Golgi to the endoplasmic reticulum
Interaction with the K-D-E-L motif on target proteins
Loss of binding to the sequence motif K-D-E-L.
Involved in proton transfer during cleavage
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Methylthioribulose-1-phosphate dehydratase
Cellular retinoic acid-binding protein 1
Polypeptide N-acetylgalactosaminyltransferase
Receptor-type tyrosine-protein phosphatase alpha
Large ribosomal subunit protein uL30 N-terminal eukaryotes
Large ribosomal subunit protein uL30-like ferredoxin-like fold
SAPK-interacting protein 1 Pleckstrin-homology
Target of rapamycin complex 2 subunit MAPKAP1
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
Suppressor of tumorigenicity 7 protein-like
Phosphatidylcholine-sterol acyltransferase
Transcription initiation factor IIA gamma subunit C-terminal
Transcription initiation factor IIA gamma subunit N-terminal
Required for CHRNB3 transcription activation but not for DNA binding
V-type proton ATPase 116 kDa subunit a 1
Neuronal vesicle trafficking-associated protein 1
WD repeat beta-propeller B; Interaction with CUL4A
DNA replication ATP-dependent helicase/nuclease DNA2
Calcium release-activated calcium channel protein 1
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial
Uncharacterized protein KIAA1143 homolog
SET and MYND domain-containing protein 4
Schiff-base intermediate with acetaldehyde
Corticotropin-releasing factor receptor 1
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
UbiA prenyltransferase domain-containing protein 1
UDP-glucuronate decarboxylase N-terminal
Cysteine persulfide intermediate; for sulfurtransferase activity
Glycyl thioester intermediate; for adenylyltransferase activity
FHF complex subunit HOOK-interacting protein C-terminal
Transcription initiation factor TFIID subunit 2
Exocyst complex component EXOC2/Sec5 N-terminal
Translationally-controlled tumor protein homolog
Amiloride-sensitive sodium channel subunit alpha
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
Vitelline membrane outer layer protein 1
In CHO.MUTCFR mutant; unable to regulate FGF levels and is detected throughout the cell.
M-loop required for interaction with nucleosome linker DNA
Reduced interaction with DNA; when associated with Q-107 and Q-109.
Reduced interaction with DNA; when associated with Q-99 and Q-107.
Reduced interaction with DNA; when associated with Q-99 and Q-109.
Required for oligomerization and DNA condensation
Strongly reduced inhibition of cysteine proteases.
Damage-control phosphatase ARMT1-like metal-binding
Tudor-interacting repair regulator protein
H/ACA ribonucleoprotein complex subunit DKC1
Adenine-nucleotide binding in RNA target
Guanine-nucleotide binding in RNA target
Non-specific-nucleotide binding in RNA target
Failed axon connections homolog N-terminal
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
Platelet-derived growth factor C, latent form
Platelet-derived growth factor C, receptor-binding form
ATP-dependent RNA helicase SUPV3L1, mitochondrial
Serine/threonine-protein kinase receptor
Interferon-related developmental regulator C-terminal
Interferon-related developmental regulator N-terminal
Schiff-base intermediate with substrate; via topaquinone
Cytosolic Fe-S cluster assembly factor NUBP2
Mitochondrial outer membrane protein SLC25A46
Peptidase metallopeptidase domain-containing protein
AT-rich interactive domain-containing protein 5B
Target of Myb1 membrane trafficking protein
ST]-E-Y-X(3)-F motif 1; required for efficient microtubule binding and stabilization
ST]-E-Y-X(3)-F motif 2; required for efficient microtubule binding and stabilization
ST]-E-Y-X(3)-F motif 3; required for efficient microtubule binding and stabilization
Eukaryotic translation initiation factor 2 subunit 3
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B
Janus kinase and microtubule-interacting protein C-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Polyadenylate-binding protein-interacting protein 2
Replication protein A 70 kDa DNA-binding subunit
Torsin-1A-interacting protein 1/2 AAA+ activator
Large ribosomal subunit protein uL2 C-terminal
Voltage-dependent L-type calcium channel subunit alpha-1D
Histone RNA hairpin-binding protein RNA-binding
Ectonucleoside triphosphate diphosphohydrolase 8
Protein kinase C and casein kinase substrate in neurons protein 2
Extracellular and involved in cell to cell contact
4 X 24 AA approximate tandem repeats of T-[AD]-[EG]-D-[AV]-[AV]-[AG]-[AP]-T-[AP]-[AG]-A-T-A-[AE]-[DS]-[IV]-A-[DV]-[DP]-T-A-G-A
In strain: Black Langshan, Broiler, Dun and Red jungle fowl.
In strain: Broiler, Dun and Red jungle fowl.
Dihydroorotate dehydrogenase (quinone), mitochondrial
Na(+)/H(+) exchange regulatory cofactor NHE-RF1
Myb/SANT-like DNA-binding domain-containing protein 2
ER membrane protein complex subunit 7 beta-sandwich
Vascular endothelial growth factor receptor 1
Histone deacetylase complex subunit SAP130
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
PiggyBac transposable element-derived protein
tRNA (32-2'-O)-methyltransferase regulator THADA
Transmembrane protein TMEM132 C-terminal
Transmembrane protein TMEM132 N-terminal
Neuronal PAS domain-containing protein 2
Sufficient for heterodimer formation with BMAL1, E-box binding and for the effect of NADPH
Reactive bond 6 for chymotrypsin and elastase
Reactive bond 7 for chymotrypsin and elastase
Pyrroline-5-carboxylate reductase dimerisation
Neuronal acetylcholine receptor subunit alpha-5
O-linked (Xyl...) (dermatan sulfate) serine
U3 small nucleolar RNA-associated protein 15 homolog
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
Basic helix-loop-helix ARNT-like protein 2
Eukaryotic translation initiation factor 1
Gamma-aminobutyric acid receptor subunit beta-3
Trimeric intracellular cation channel type A
Loss of Ca(2+) mobilization; when associated with F-194 and F-205. Significant phosphorylation reduction; when associated with F-91; F-103; F-115 and F-194. Loss of phosphorylation; when associated with F-91; F-103; F-115; F-194 and F-249.
Loss of phosphorylation; when associated with F-91; F-103; F-115; F-194 and F-205.
Reduction in Ca(2+) mobilization. Significant reduction of Ca(2+) mobilization; when associated with F-103. Loss of Ca(2+) mobilization; when associated with F-103 and F-205. Significant phosphorylation reduction; when associated with F-91; F-103; F-115 and F-205. Loss of phosphorylation; when associated with F-91; F-103; F-115; F-205 and F-249.
Significant phosphorylation reduction; when associated with F-103; F-115; F-194 and F-205. Loss of phosphorylation; when associated with F-103; F-115; F-194; F-205 and F-249.
Significant phosphorylation reduction; when associated with F-91; F-103; F-194 and F-205. Loss of phosphorylation; when associated with F-91; F-103; F-194; F-205 and F-249.
Significant reduction of Ca(2+) mobilization; when associated with F-194. Loss of Ca(2+) mobilization; when associated with F-194 and F-205. Significant phosphorylation reduction; when associated with F-91; F-115; F-194 and F-205. Loss of phosphorylation; when associated with F-91; F-115; F-194; F-205 and F-249.
Strongly reduced tyrosine phosphorylation. Strongly reduced activation of NFAT.
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Protein-L-histidine N-pros-methyltransferase
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2
Cleavage; by thrombin; to release fibrinopeptide B
Nuclear receptor-binding factor 2 C-terminal
POU domain, class 2, transcription factor 1
DNA repair and recombination protein RAD54B
Polyribonucleotide 5'-hydroxyl-kinase Clp1
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
Complete loss of activity; when associated with Ala-140.
Complete loss of activity; when associated with Ala-142.
Less than 10% activity toward polysaccharide substrates.
Only transfers sulfates to GlcA moieties within the polysaccharide.
Preferentially transfers sulfates to IdoA units.
Inositol polyphosphate-related phosphatase
Interaction with coactivator LXXLL motif
Interchain (between heavy and light chains)
Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding
Proton donor; shared with dimeric partner
Stacks against the aromatic ring of pyridoxal phosphate and stabilizes reaction intermediates
Lutropin-choriogonadotropic hormone receptor
Important for binding to glycosaminoglycan chains
Loss of heparin binding; when associated with A-96.
Loss of heparin binding; when associated with A-99.
Receptor-type tyrosine-protein phosphatase S
Dynein regulatory complex protein 1 C-terminal
Dynein regulatory complex protein 1/2 N-terminal
RecQ-mediated genome instability protein 2
Tumor necrosis factor alpha-induced protein 8-like protein 1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Hematopoietically-expressed homeobox protein HHEX
Protein phosphatase 1 regulatory subunit 21
ATP is exchanged at an increased rate; decreased the thermal stability of actin monomers.
Actin, cytoplasmic 1, N-terminally processed
N-acetylaspartate; in Actin, cytoplasmic 1, N-terminally processed
N-acetylmethionine; in Actin, cytoplasmic 1; alternate
N-linked (GlcNAc...) asparagine; partial
Reactive bond 1 for endoproteinase Lys-C
Metallo-beta-lactamase domain-containing protein
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Gamma-glutamylcyclotransferase AIG2-like
Zinc finger and BTB domain-containing protein 7A
Vacuolar protein sorting-associated protein 53 homolog
Calcitonin gene-related peptide type 1 receptor
Mini-chromosome maintenance complex-binding protein
Essential for determining substrate specificity
Important for interaction with lipoprotein particles
N-linked (GlcNAc...) (complex) asparagine
No change in heparin-binding activity nor in specific enzymatic activity. Reduced heparin-binding activity and decreased specific enzymatic activity; when associated with N-441.
Reduced heparin-binding ability and some decrease in specific enzymatic activity.
Reduced heparin-binding ability and some reduction in specific enzymatic activity. Almost complete loss of heparin binding and greatly reduced specific enzymatic activity; when associated with N-432 and N-434.
Reduced heparin-binding ability. Almost complete loss of heparin binding and greatly reduced specific enzymatic activity; when associated with N-430 and N-432.
Reduced heparin-binding ability. Almost complete loss of heparin binding and greatly reduced specific enzymatic activity; when associated with N-430 and N-434.
Reduced heparin-binding activity and decreased specific enzymatic activity. No further reduction of heparin-binding nor of specific enzymatic activity; when associated with N-440.
Some loss of heparin-binding ability; when associated with Q-306 and Q-307.
Some loss of heparin-binding ability; when associated with Q-306 and Q-309.
Some loss of heparin-binding ability; when associated with Q-307 and Q-309.
Gamma-aminobutyric acid receptor subunit gamma-4
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Insulin-like growth factor-binding protein 1
Glycine cleavage system H protein, mitochondrial
RNA-polymerase II-associated protein 3-like C-terminal
Neuronal acetylcholine receptor subunit alpha-6
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Lower thermal denaturation temperature, more susceptible to elastase or subtilisin cleavage and assumes a native-like conformation on alkaline treatment; when associated with or without A-121.
Lower thermal denaturation temperature, more susceptible to elastase or subtilisin cleavage and assumes a native-like conformation on alkaline treatment; when associated with or without A-74.
Significantly more thermostabilized following cleavage at P-P' site. Inserts reactive loop at very slow rate. No inhibitory action against serine proteinases.
Chromodomain-helicase-DNA-binding protein 7
Eukaryotic translation initiation factor 3 subunit E
LHFPL tetraspan subfamily member 5 protein
F-actin-capping protein subunit beta isoforms 1 and 2
Intracellular hyaluronan-binding protein 4
Leucine-rich repeat-containing protein 59
Insulin-like growth factor-binding protein 2
No significant effect on affinity for ATP and Ca(2+)-calmodulin.
Strongly decreased affinity for ATP and Ca(2+)-calmodulin. Abolishes ATP-mediated increase in channel sensitivity to agonists.
Strongly decreased affinity for ATP and slightly decreased affinity for Ca(2+)-calmodulin.
Transient receptor potential cation channel subfamily V member 4
Reduces interaction with HOXD12; in association with P-309.
Reduces interaction with HOXD12; in association with P-316.
DNA polymerase alpha/delta/epsilon subunit B
Mitochondrial apoptosis-inducing factor C-terminal
Endosomal/lysosomal proton channel TMEM175
Cleavage/polyadenylation specificity factor A subunit C-terminal
Cleavage/polyadenylation specificity factor A subunit N-terminal
CSC1/OSCA1-like N-terminal transmembrane
Mothers against decapentaplegic homolog 5
Structural maintenance of chromosomes protein 2
Impairs channel activity; when associated with missing 464-L--C-527.
No effect on channel activity; when associated with missing 1-M--S-13. Impairs channel activity; when associated with missing 1-M--S-25.
No effect on channel activity; when associated with missing 464-L--C-527.
Strongly increases speed of desensitation.
Transcription initiation factor TFIID subunit 3
Aspartate aminotransferase, mitochondrial
5 X 7 AA tandem repeats of X-T-P-X-K-K-X
FXYD domain-containing ion transport regulator
Integrin alpha-2 domain-containing protein
Multiple myeloma tumor-associated protein 2-like N-terminal
Ankyrin repeat domain-containing protein 10
Abolishes transactivation activity. when associated with A-65.
Abolishes transactivation activity; when associated with A-14.
Arylamine N-acetyltransferase, pineal gland isozyme NAT-10
Muscle, skeletal receptor tyrosine protein kinase
Hyaluronan-binding motif involved in chondroitin sulfate A-binding
Hyaluronan-binding motif involved in chondroitin sulfate C-binding
Interphotoreceptor matrix proteoglycan 2
cAMP-dependent protein kinase inhibitor alpha
Low-density lipoprotein receptor-related protein 1
Recognition site for proteolytical processing
Histone-lysine N-trimethyltransferase SMYD5
Platelet-activating factor acetylhydrolase
EGF domain-specific O-linked N-acetylglucosamine transferase
Ubiquitin-conjugating enzyme E2 variant 1
Proheparin-binding EGF-like growth factor
TBC domain-containing protein kinase-like protein
Eukaryotic translation initiation factor 3 subunit H
Important for DNA bending; intercalates between base pairs of target DNA
O-(5'-phospho-DNA)-tyrosine intermediate
Nuclear distribution protein nudE homolog 1
p21-activated protein kinase-interacting protein 1-like
RNA 2-O ribose methyltransferase substrate binding
Protein-L-isoaspartate(D-aspartate) O-methyltransferase
Peptidyl-prolyl cis-trans isomerase-like 3
2-oxoglutarate and iron-dependent oxygenase JMJD4
Multiple inositol polyphosphate phosphatase 1
Two-fold greater substrate affinity and doubling of catalytic activity.
Solute carrier family 2, facilitated glucose transporter member 1
Potassium voltage-gated channel subfamily G member 2
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Photoreceptor outer segment membrane glycoprotein 2
Tumor necrosis factor receptor superfamily member 5
Micro-fibrillar-associated protein 1 C-terminal
Tumor necrosis factor receptor superfamily member 11B
Cyanocobalamin reductase / alkylcobalamin dealkylase
Plasma membrane calcium-transporting ATPase 1
N6-adenosine-methyltransferase non-catalytic subunit
Positively charged region required for RNA-binding
Large ribosomal subunit protein uL6 alpha-beta
Musculoskeletal embryonic nuclear protein 1
Adenomatous polyposis coli N-terminal dimerisation
Adenomatous polyposis coli protein basic
Biogenesis of lysosome-related organelles complex 1 subunit 5
Gamma-aminobutyric acid receptor subunit beta-4
Sodium/potassium-transporting ATPase subunit alpha-1
Sufficient for localization to endoplasmic reticulum tubular network
Transcription elongation factor Eaf N-terminal
Abolished proton-coupled folate transport.
Strong proton-coupled folate transport at pH 7.5.
Strongly reduced proton-coupled folate transport.
reversibly protonated residue during proton transport
Coiled-coil domain-containing protein 93
Abolishes the ability to form a mixed-disulfide with GDPD5; when associated with S-173.
Abolishes the ability to form a mixed-disulfide with GDPD5; when associated with S-52.
Cysteine sulfenic acid (-SOH) intermediate
Troponin C, slow skeletal and cardiac muscles
Abolishes phosphorylation following BCR activation; when associated with A-26.
Helical; Signal-anchor for type III membrane protein
Linker for activation of T-cells family member 2
Harmonin-binding protein USHBP1 PDZ-binding
Vacuolar protein sorting-associated protein 54 C-terminal
Vacuolar protein sorting-associated protein 54 N-terminal
LysM and putative peptidoglycan-binding domain-containing protein 3
Gamma-aminobutyric acid receptor subunit gamma-2
Insertion, similar to human gamma-2 sequence which is proposed to be caused by alternative splicing
Sodium-dependent lysophosphatidylcholine symporter 1
Nuclear receptor-interacting protein 1 repression
Cholesterol recognition/amino acid consensus (CRAC) region
Endoplasmic reticulum membrane sensor NFE2L1
T-cell acute lymphocytic leukemia protein 1 homolog
Fibroblast growth factor receptor-like 1
18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal
Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil
Ubiquitin-conjugating enzyme E2 variant 2
Nicotinamide phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Necessary for nuclear localization and splicing activity
RAF proto-oncogene serine/threonine-protein kinase
Basic helix-loop-helix ARNT-like protein 1
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2 and SUMO3)
N-acetylthreonine; in GTPase HRas, N-terminally processed
Brain-specific homeobox/POU domain protein 3
Cotranscriptional regulator FAM172A homolog
Lack of phosphorylation; when associated with S-750.
Lack of phosphorylation; when associated with T-753.
U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein
26S proteasome non-ATPase regulatory subunit 1
Trafficking protein particle complex subunit 5
Iroquois-class homeodomain protein IRX-4
Actin, gamma-enteric smooth muscle, intermediate form
N-acetylglutamate; in Actin, gamma-enteric smooth muscle
5-glutamyl coenzyme A thioester intermediate
Potassium voltage-gated channel subfamily A member 10
ATP synthase subunit beta, mitochondrial
V region (type III connecting segment, IIICS)
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
Myeloid differentiation primary response protein MyD88
Transcription factor CBF/NF-Y/archaeal histone
Sodium:neurotransmitter symporter serotonin N-terminal
DNA repair and recombination protein RAD54-like
Receptor-type tyrosine-protein phosphatase eta
CCR4-NOT transcription complex subunit 1
CCR4-NOT transcription complex subunit 1 CAF1-binding
CCR4-NOT transcription complex subunit 1 HEAT repeat
CCR4-NOT transcription complex subunit 1 TTP binding
CCR4-Not complex component Not1 C-terminal
Translocon-associated protein subunit alpha
Central conserved domain (CCD); required for localization to endoplasmic reticulum exit sites
Phosphorylated adapter RNA export protein
Mitochondrial import inner membrane translocase subunit Tim9
Rho guanine nucleotide exchange factor 3
In isoform Brain l-cad and isoform Gizzard l-cad.
Probable ATP-dependent RNA helicase DDX6
Phosphomannose isomerase type I C-terminal
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
High affinity immunoglobulin epsilon receptor subunit gamma
Eukaryotic translation initiation factor 2A
Mapk-regulated corepressor-interacting protein 1
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form
Heterogeneous nuclear ribonucleoprotein D-like
Important for obstruction of the ion pore in the closed conformation
Abolishes sequence-specific DNA binding; when associated with A-15 and A-41.
Abolishes sequence-specific DNA binding; when associated with A-15 and A-70.
Abolishes sequence-specific DNA binding; when associated with A-41 and A-70.
Endoplasmic reticulum resident protein 29
Endoplasmic reticulum resident protein 29 C-terminal
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial
Ras-specific guanine nucleotide-releasing factor RalGPS1
Complete loss of binding to VTG2 promoter in isoform 3.
Ancestral coatomer element 1 Sec16/Sec31
GDP-fucose protein O-fucosyltransferase 1
NF-kappa-B-activating protein C-terminal
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter C-terminal
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter N-terminal
Cell division control protein 42 homolog
Signal transducer and activator of transcription 3
GPI ethanolamine phosphate transferase 2 C-terminal
Proline-rich nuclear receptor coactivator 2
Abolishes sumoylation; when associated with A-181. Abolishes phosphorylation; when associated with A-181. Reduces ability to associate with UBE2I; when associated with A-181. Prevents trunk neural crest delamination; when associated with A-181. Prevents cooperating with SNAI2 to trigger neural crest delamination; when associated with A-181. Abolishes interaction with SNAI2; when associated with A-181.
Abolishes sumoylation; when associated with A-64. Abolishes phosphorylation; when associated with A-64. Reduces ability to associate with UBE2I; when associated with A-64. Prevents trunk neural crest delamination; when associated with A-64. Prevents cooperating with SNAI2 to trigger neural crest delamination; when associated with A-64. Abolishes interaction with SNAI2; when associated with A-64.
Decreases cooperating with SNAI2 to trigger neural crest delamination; when associated with R-254 and R-376.
Decreases cooperating with SNAI2 to trigger neural crest delamination; when associated with R-61 and R-254.
Decreases cooperating with SNAI2 to trigger neural crest delamination; when associated with R-61 and R-376.
Sumoylation; when associated with D-181. Initiates trunk neural crest delamination; when associated with D-181. Allows cooperating with SNAI2 to trigger neural crest delamination; when associated with D-181. Allows interaction with SNAI2; when associated with D-181.
Sumoylation; when associated with D-64. Initiates trunk neural crest delamination; when associated with D-64. Allows cooperating with SNAI2 to trigger neural crest delamination; when associated with D-64. Allows interaction with SNAI2; when associated with D-64.
Thioredoxin reductase-like selenoprotein T
NADH:ubiquinone oxidoreductase intermediate-associated protein 30
Small ribosomal subunit protein uS17 N-terminal
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
HAUS augmin-like complex subunit 6 N-terminal
Nuclear distribution protein nudE-like 1
Important for selectivity against fructose
Solute carrier family 2, facilitated glucose transporter member 3
Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin)
120 kDa linear IgA disease antigen homolog
Interchain (with TAPBP); in linked form; reversible
Lowers pKa of C-terminal Cys of first active site
Lowers pKa of C-terminal Cys of second active site
RNA cytosine-C(5)-methyltransferase NSUN2
Serine/threonine-protein phosphatase 4 regulatory subunit 2
Abolishes homodimerization and up-regulation of NOG mRNA levels. Loss of function in gastrointestinal smooth muscle cell differentiation and in gastrointestinal smooth muscle development.
RNA-binding protein with multiple splicing 2
Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain
Insulin-like growth factor-binding protein 4
Ubiquitin carboxyl-terminal hydrolase 48
Mesoderm induction early response protein 1
BMP/retinoic acid-inducible neural-specific protein 1
Potassium channel inwardly rectifying Kir N-terminal
Hydroxyacylglutathione hydrolase, mitochondrial
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Required and sufficient for targeting to lysosomes and lamellar bodies
Decreases transcriptional activity at low hormone concentration. Does not alter hormone binding affinity.
Decreases transcriptional activity independently of hormone concentration. Does not alter hormone binding affinity.
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2
Small nuclear ribonucleoprotein-associated protein B'
Beta-galactoside alpha-2,6-sialyltransferase 1
Sigma non-opioid intracellular receptor 1
Sodium/potassium-transporting ATPase subunit beta-1
In strain: 16, 17, 25, 7, Black Minorca, Fayoumi GSP, WL-F and WL-N.
In strain: 16, 17, 25, 7, Black-bone, Black Minorca, Fayoumi GSP, WL-F and WL-N.
In strain: 16, 17, 25, Black Minorca, Fayoumi GSP and WL-F.
In strain: 25, 7, Black-bone, Black Minorca, Fayoumi GSP, WL-F and WL-N.
In strain: 25, Black Minorca, Fayoumi GSP and WL-F.
In strain: 25, Black-bone, WL-F and WL-N.
In strain: Black Minorca and Fayoumi GSP.
Interferon-induced GTP-binding protein Mx
Required for P-body targeting and interaction with DCP1A
WD repeat and coiled-coil-containing protein
Saccharopine dehydrogenase-like C-terminal
Nuclear receptor subfamily 5 group A member 2
Glycylpeptide N-tetradecanoyltransferase C-terminal
Glycylpeptide N-tetradecanoyltransferase N-terminal
Mediator of RNA polymerase II transcription subunit 17
Multidrug resistance-associated protein 1
Coiled-coil domain-containing protein 43
G2 and S phase-expressed protein 1 N-terminal
Ankyrin repeat domain-containing protein 1
Glucose-induced degradation protein 8 homolog
Pterin-4-alpha-carbinolamine dehydratase
Enhancer of mRNA-decapping protein 4 WD40 repeat region
V-set and immunoglobulin domain-containing protein 1
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Solute carrier family 2, facilitated glucose transporter member 2
Double-strand break repair protein MRE11
Activation domain; required for transcription activation
GPI-GlcNAc transferase complex PIG-H component conserved
Contributes to single strand DNA binding activity
Required for hexamers formation and DNA helicase activity
Ribose-phosphate pyrophosphokinase N-terminal
Iron-sulfur cluster assembly 1 homolog, mitochondrial
U3 small nucleolar RNA-associated protein 25 homolog
Cysteine-rich DPF motif domain-containing protein 1
Domain of unknown function with conserved HDNR motif
Pleckstrin homology domain-containing family B member 2
Schiff-base intermediate with DNA; for 5'-deoxyribose-5-phosphate lyase activity
X-ray repair cross-complementing protein 5
Proto-oncogene tyrosine-protein kinase Src
Significant reduction in S-nitrosylation.
May act as a substrate filter by repelling compounds with a negatively charged alpha-carboxylate
Beta-1,3-N-acetylglucosaminyltransferase radical fringe
Basic helix-loop-helix transcription factor scleraxis
Tumour necrosis factor receptor 13C TALL-1 binding
Phosphoethanolamine/phosphocholine phosphatase
Adipocyte plasma membrane-associated protein
Urokinase-type plasminogen activator chain A
Urokinase-type plasminogen activator chain B
Phosphatidylinositol-specific phospholipase C X
6-phosphogluconate dehydrogenase C-terminal
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)
Parathyroid hormone/parathyroid hormone-related peptide receptor
Necessary and sufficient for homooligomerization and localization to centrosomes and pericentriolar satellites
Sodium/potassium-transporting ATPase subunit beta-3
ATPsynthase alpha/beta subunit N-terminal extension
Leucine-rich repeat-containing protein 40
Ubiquitin-like domain-containing CTD phosphatase 1
BMP and activin membrane-bound inhibitor C-terminal
BMP and activin membrane-bound inhibitor N-terminal
BMP and activin membrane-bound inhibitor homolog
Natural resistance-associated macrophage protein 1