Major facilitator superfamily (MFS) profile
ATP synthase F1 complex delta/epsilon subunit N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
DNA-directed RNA polymerase RpoA/D/Rpb3-type
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Pyruvate dehydrogenase E1 component middle
UDP N-acetylglucosamine O-acyltransferase C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
TRAP C4-dicarboxylate transport system permease DctM subunit
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
PHA accumulation regulator DNA-binding N-terminal
Polymerase/histidinol phosphatase N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Trimeric autotransporter adhesin YadA-like head
Trimeric autotransporter adhesin YadA-like stalk
TonB-dependent receptor-like beta-barrel
Helix-hairpin-helix DNA-binding motif class 1
Cytochrome b561 bacterial/Ni-hydrogenase
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Resolvase/invertase-type recombinase catalytic
Glycosyltransferase subfamily 4-like N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Trimeric autotransporter adhesin YadA-like C-terminal membrane anchor
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Meso-diaminopimelate D-dehydrogenase C-terminal
Plays an important role in substrate specificity
Tryptophan synthase beta chain-like PALP
Essential for prephenate dehydratase activity
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Rap1a immunity protein domain-containing protein
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
S-adenosyl-L-homocysteine hydrolase NAD binding
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Type IV secretion system coupling protein TraD DNA-binding
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Flagellar assembly protein FliH/Type III secretion system HrpE
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
TonB C-terminal domain-containing protein
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase-like C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
L-seryl-tRNA selenium transferase N-terminal
ABC-type glycine betaine transport system substrate-binding
Penicillin-binding protein transpeptidase
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Survival protein SurE-like phosphatase/nucleotidase
Interaction with polymerase core subunit RpoC
Flagellar hook-length control protein-like C-terminal
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Required for zinc-mediated homotetramerization and catalytic activity
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
DNA replication/recombination mediator RecO N-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Thymidylate synthase/dCMP hydroxymethylase
Prokaryotic-type class I peptide chain release factors
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Saccharopine dehydrogenase-like C-terminal
RNA polymerase sigma factor 70 region 4 type 2
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
EfeO-type cupredoxin-like domain-containing protein
Nitrite/Sulfite reductase ferredoxin-like
Pyridoxamine 5'-phosphate oxidase putative
Solute-binding protein family 3/N-terminal
Poly-beta-hydroxybutyrate polymerase N-terminal
Superoxide dismutase copper/zinc binding
Organic solvent tolerance-like N-terminal
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Chalcone isomerase domain-containing protein
Interacts with tRNA; defines subfamily-specific binding signature
Exonuclease VII large subunit C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Tellurite resistance methyltransferase TehB-like
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Reversibly protonated during proton transport
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:ubiquinone/plastoquinone oxidoreductase chloroplast chain 5 C-terminal
Phosphoadenosine phosphosulphate reductase
RNA binding; important for wobble base 34 recognition
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Anthranilate synthase component I N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Inner membrane protein YgaP-like transmembrane
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
CagE TrbE VirB component of type IV transporter system central
RND efflux pump membrane fusion protein barrel-sandwich
YbaK/aminoacyl-tRNA synthetase-associated
Glucosamine/galactosamine-6-phosphate isomerase
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Large ribosomal subunit protein uL2 C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
NIF system FeS cluster assembly NifU N-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
Helix-turn-helix conjugative transposon-like
Large ribosomal subunit protein uL15/eL18
N-end rule aminoacyl transferase C-terminal
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Siderophore-interacting protein C-terminal
Flagellar motor switch protein FliN-like C-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
O-(3'-phospho-DNA)-tyrosine intermediate
Phosphogluconate dehydrogenase NAD-binding putative C-terminal
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glycosyl transferase family 3 N-terminal
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Aspartate/homoserine dehydrogenase NAD-binding
Cysteine sulfenic acid (-SOH) intermediate
Pyruvate phosphate dikinase AMP/ATP-binding
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Chromosomal replication initiator DnaA C-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Integral membrane protein YccS N-terminal
Cytochrome oxidase subunit II copper A binding
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase
Uroporphyrinogen-III C-methyltransferase
Acetyl-CoA dehydrogenase-like C-terminal
Small ribosomal subunit protein uS4 N-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Ionotropic glutamate receptor C-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Phosphotransferase system enzyme I N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Translation elongation factor P/YeiP central
Pseudouridine synthase I TruA alpha/beta
ATP-dependent DNA helicase RecG C-terminal
Formylmethanofuran dehydrogenase subunit E
Outer membrane protein assembly factor BamB
Alanyl-transfer RNA synthetases family profile
Cytochrome c-type biogenesis protein CcmF C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
tRNA(Ile)-lysidine synthase substrate-binding
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Lytic transglycosylase superhelical linker
ABC-type transport auxiliary lipoprotein component
Mandelate racemase/muconate lactonizing enzyme C-terminal
Outer membrane protein assembly factor BamA
NADH:ubiquinone oxidoreductase 30kDa subunit
Cobalamin-independent methionine synthase MetE N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
tRNA pseudouridylate synthase B C-terminal
Proline utilization A proline dehydrogenase N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Membrane fusion protein biotin-lipoyl like
Polysaccharide chain length determinant N-terminal
Bacterial type II secretion system protein E
Beta-lactamase hydrolase-like protein phosphatase-like
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Molybdopterin cofactor biosynthesis C (MoaC)
Nickel uptake substrate-specific transmembrane region
RNA 2-O ribose methyltransferase substrate binding
Polysaccharide biosynthesis protein CapD-like
Glycine cleavage T-protein C-terminal barrel
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Important for interaction with partner proteins
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Flavocytochrome c sulphide dehydrogenase flavin-binding
Na+/H+ antiporter MnhB subunit-related protein
Aminoacyl-tRNA synthetase class I anticodon-binding
Positions MEP for the nucleophilic attack
Ribosomal RNA adenine methylase transferase N-terminal