Membrane fusion protein biotin-lipoyl like
Translation elongation factor P/YeiP central
Carboxymuconolactone decarboxylase-like domain-containing protein
Major facilitator superfamily (MFS) profile
3-keto-disaccharide hydrolase domain-containing protein
DNA replication/recombination mediator RecO N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Glycosyltransferase subfamily 4-like N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Moybdenum cofactor oxidoreductase dimerisation
Transcriptional coactivator p15 (PC4) C-terminal
Tryptophan synthase beta chain-like PALP
Glucosamine/galactosamine-6-phosphate isomerase
Endonuclease/exonuclease/phosphatase domain-containing protein
RND efflux pump membrane fusion protein barrel-sandwich
Cytochrome C biogenesis protein transmembrane
Thiol:disulfide interchange protein DsbD N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Important for beta-aspartyl-AMP intermediate formation
RNA polymerase sigma factor 70 region 4 type 2
Glycosyltransferase RgtA/B/C/D-like domain-containing protein
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Bacterial type II secretion system protein E
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH:ubiquinone/plastoquinone oxidoreductase chloroplast chain 5 C-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Outer membrane lipoprotein-sorting protein
Solute-binding protein family 3/N-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
CobB/CobQ-like glutamine amidotransferase
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Na+-translocating membrane potential-generating system MpsC
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Putative Flp pilus-assembly TadG-like N-terminal
PEP-CTERM exosortase interaction domain-containing protein
Helix-hairpin-helix DNA-binding motif class 1
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Peptidase S9 prolyl oligopeptidase catalytic
Thiamine pyrophosphate enzyme TPP-binding
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Phosphatidic acid phosphatase type 2/haloperoxidase
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Positions MEP for the nucleophilic attack
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Alpha glucuronidase N-terminal domain-containing protein
Glycerophosphoryl diester phosphodiesterase
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Gfo/Idh/MocA-like oxidoreductase bacterial type C-terminal
Polymerase/histidinol phosphatase N-terminal
Resolvase/invertase-type recombinase catalytic
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Proton acceptor; for glutaminase activity
Carboxypeptidase regulatory-like domain-containing protein
Mandelate racemase/muconate lactonizing enzyme C-terminal
Glycoside hydrolase 123 C-terminal domain-containing protein
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Leucine Rich Repeat (LRR)-containing protein
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
PhoD-like phosphatase metallophosphatase
Right handed beta helix domain-containing protein
Increases nucleophilicity of active site Cys
Carbohydrate-binding domain-containing protein
tRNA pseudouridylate synthase B C-terminal
Anaphase-promoting complex subunit 4-like WD40
Choice-of-anchor A domain-containing protein
6-phosphogluconate dehydrogenase C-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
N,N-dimethylformamidase beta subunit-like C-terminal
Large ribosomal subunit protein uL15/eL18
Cytochrome b/b6 N-terminal region profile
NADH:ubiquinone oxidoreductase 30kDa subunit
Pyrroline-5-carboxylate reductase catalytic N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Histidine-specific methyltransferase SAM-dependent
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Phosphotransferase system enzyme I N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family protein
Could be important to modulate the pK values of the two catalytic cysteine residues
Lactate utilization protein B C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Putative glycogen debranching enzyme N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Phosphoadenosine phosphosulphate reductase
Glycoside hydrolase family 57 N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Essential for prephenate dehydratase activity
Sulfatase-modifying factor enzyme domain-containing protein
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Sodium/calcium exchanger membrane region
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
LamG-like jellyroll fold domain-containing protein
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Lipocalin-like domain-containing protein
Superoxide dismutase copper/zinc binding
Phosphomannose isomerase type I catalytic
Plays an important role in substrate specificity
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Alanyl-transfer RNA synthetases family profile
Transglutaminase-like superfamily protein
Protein-L-isoaspartate O-methyltransferase
SGNH hydrolase-type esterase domain-containing protein
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Alpha-D-phosphohexomutase alpha/beta/alpha
DNA mismatch repair proteins mutS family
Anthranilate synthase component I N-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Pyruvate phosphate dikinase AMP/ATP-binding
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Signal transduction histidine kinase osmosensitive K+ channel sensor N-terminal
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Methylene-tetrahydromethanopterin dehydrogenase N-terminal
Beta-lactamase hydrolase-like protein phosphatase-like
Carbohydrate binding module xylan-binding
Diacylglycerol glucosyltransferase N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Glycosyl-hydrolase 97 C-terminal oligomerisation
Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr C-terminal
Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Transcriptional regulator TetR C-terminal Proteobacteria type
Cytochrome b/b6 C-terminal region profile
Membrane insertase YidC/Oxa/ALB C-terminal
Nucleophile; cysteine thiosulfonate intermediate
Type II secretion system protein GspE N-terminal
Flagellar motor switch protein FliN-like C-terminal
N-sulphoglucosamine sulphohydrolase C-terminal
SUF system FeS cluster assembly SufBD N-terminal
Methionyl-tRNA synthetase anticodon-binding
Ribose-phosphate pyrophosphokinase N-terminal
N-(5'-phosphoribosyl)anthranilate isomerase
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
NIF system FeS cluster assembly NifU C-terminal
Cobalamin-independent methionine synthase MetE N-terminal
Cysteine sulfenic acid (-SOH) intermediate
Prepilin type IV endopeptidase peptidase
Gamma-glutamylcyclotransferase AIG2-like
DNA-directed DNA polymerase family A palm
Periplasmic copper-binding protein NosD beta helix
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Peptidase M17 leucyl aminopeptidase N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Transcription factor NikR nickel binding C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Pseudouridine synthase I TruA alpha/beta
ATP synthase F1 complex delta/epsilon subunit N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Peptidase MA-like domain-containing protein
Reversibly protonated during proton transport
Endoribonuclease L-PSP/chorismate mutase-like
Glycosyl hydrolase family 98 putative carbohydrate-binding module
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Gamma-butyrobetaine hydroxylase-like N-terminal
Glycosyl transferase family 3 N-terminal
Glycosyltransferase family 28 N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
3-beta hydroxysteroid dehydrogenase/isomerase
Heme-copper oxidase subunit III family profile
Molybdopterin cofactor biosynthesis C (MoaC)
Peptidoglycan recognition protein family
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Lipid/polyisoprenoid-binding YceI-like domain-containing protein
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
UDP-glucose/GDP-mannose dehydrogenase C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Chromosomal replication initiator DnaA C-terminal
Peptidase C-terminal archaeal/bacterial domain-containing protein
Acetylserotonin O-methyltransferase dimerisation
Pyrroline-5-carboxylate reductase dimerisation
Trigger factor ribosome-binding bacterial
PEP-CTERM sorting domain-containing protein
Schiff-base intermediate with acetaldehyde
Important for interaction with partner proteins
Ribosomal RNA adenine methylase transferase N-terminal
K(+)-insensitive pyrophosphate-energized proton pump
Secretin/TonB short N-terminal domain-containing protein
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Cytochrome c-552/4 domain-containing protein
Prokaryotic-type class I peptide chain release factors
Schiff-base intermediate with substrate; via pyruvic acid
Copper type II ascorbate-dependent monooxygenase C-terminal
ABC-type uncharacterised transport system
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
NIF system FeS cluster assembly NifU N-terminal
Neutral/alkaline non-lysosomal ceramidase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Putative regulatory protein FmdB Zinc ribbon
S-adenosylmethionine-dependent methyltransferase
YbaK/aminoacyl-tRNA synthetase-associated
Could play a key role in the communication between the regulatory and the substrate sites
Peptide methionine sulphoxide reductase MsrA
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
PsbP C-terminal domain-containing protein
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Peptidase M1 membrane alanine aminopeptidase
Methanolan biosynthesis EpsI domain-containing protein
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Glycoside hydrolase family 38 N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Regulator of nucleoside diphosphate kinase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Large ribosomal subunit protein uL2 C-terminal
Glutamate synthase alpha subunit C-terminal
Thymidylate synthase/dCMP hydroxymethylase
Glycoamylase-like domain-containing protein
Phage terminase large subunit N-terminal
DNA-3-methyladenine glycosylase AlkA N-terminal
Opioid growth factor receptor (OGFr) conserved
Peptide methionine sulfoxide reductase MsrA
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Survival protein SurE-like phosphatase/nucleotidase
Calcineurin-like phosphoesterase C-terminal
Calcineurin-like phosphoesterase N-terminal
Exonuclease VII large subunit C-terminal
Pyrimidine nucleoside phosphorylase C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Homogentisate 1,2-dioxygenase N-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Carbamoyl-phosphate synthase small subunit N-terminal
Alpha-amylase/4-alpha-glucanotransferase C-terminal
Alpha-amylase/4-alpha-glucanotransferase central
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Sialate O-acetylesterase domain-containing protein
Interaction with polymerase core subunit RpoC
Glycine cleavage T-protein C-terminal barrel
Quercetin 2,3-dioxygenase C-terminal cupin
Polysaccharide chain length determinant N-terminal
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glycerol-3-phosphate dehydrogenase [NAD(P)+]
Mechanosensitive ion channel inner membrane
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Metallo-beta-lactamase domain-containing protein
Glycoside hydrolase family 5 domain-containing protein
Threonine/serine exporter-like N-terminal
Moves into active site upon enzyme activation, plays a role in electron transfer
Periplasmic binding protein domain-containing protein
Lysidine-tRNA(Ile) synthetase C-terminal
PEP-CTERM protein-sorting domain-containing protein
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Small ribosomal subunit protein uS4 N-terminal
peptide-methionine (R)-S-oxide reductase