Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Sodium/calcium exchanger membrane region
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Na+/H+ antiporter MnhB subunit-related protein
RNA polymerase sigma factor 70 region 4 type 2
Alpha-L-arabinofuranosidase B arabinose-binding
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Translation elongation factor P/YeiP central
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Aminoacyl-transfer RNA synthetases class-II family profile
O-(5'-phospho-DNA)-tyrosine intermediate
O-(3'-phospho-DNA)-tyrosine intermediate
Helix-hairpin-helix DNA-binding motif class 1
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Glycosyltransferase subfamily 4-like N-terminal
Heat-inducible transcription repressor HrcA C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Gram-positive cocci surface proteins LPxTG domain-containing protein
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
6-phosphogluconate dehydrogenase NADP-binding
S-adenosyl-L-homocysteine hydrolase NAD binding
Formamidopyrimidine-DNA glycosylase catalytic
Major facilitator superfamily (MFS) profile
Peptidase S9 prolyl oligopeptidase catalytic
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Mandelate racemase/muconate lactonizing enzyme C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Tryptophan synthase beta chain-like PALP
Solute-binding protein family 3/N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Exonuclease VII large subunit C-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Glycine cleavage T-protein C-terminal barrel
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Alanyl-transfer RNA synthetases family profile
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Plays an important role in substrate specificity
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Peptidase C39-like domain-containing protein
Penicillin-binding protein transpeptidase
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Heme-copper oxidase subunit III family profile
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
DNA-directed DNA polymerase family A palm
Prepilin type IV endopeptidase peptidase
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Alpha-glycerophosphate oxidase C-terminal
Chromosomal replication initiator DnaA C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Peptide methionine sulphoxide reductase MsrA
Homogentisate 1,2-dioxygenase C-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Peptidase M1 membrane alanine aminopeptidase
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Large ribosomal subunit protein uL15/eL18
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
PhoD-like phosphatase metallophosphatase
Phosphoribosylformylglycinamidine synthase linker
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Histidine-specific methyltransferase SAM-dependent
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Prokaryotic-type class I peptide chain release factors
Adaptive response protein AidB N-terminal
Cell envelope-related transcriptional attenuator
Methionyl-tRNA synthetase anticodon-binding
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Glycosyl hydrolase family 98 putative carbohydrate-binding module
SGNH hydrolase-type esterase domain-containing protein
Transcription regulator AsnC/Lrp ligand binding
Beta-hexosaminidase bacterial type N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
N(4)-bis(aminopropyl)spermidine synthase C-terminal
Release factor glutamine methyltransferase N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Protein O-mannosyl-transferase C-terminal four TM
Cytochrome oxidase subunit II copper A binding
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
YbaK/aminoacyl-tRNA synthetase-associated
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Actinobacteria/chloroflexi VLRF1 release factor
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Anthranilate synthase component I N-terminal
Glucose/Sorbosone dehydrogenase domain-containing protein
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Bacterial type II secretion system protein E
Ionotropic glutamate receptor C-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Removed in mature form; by autocatalysis
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Proton acceptor; for glutaminase activity
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Alpha-D-phosphohexomutase alpha/beta/alpha
Carbamoyl-phosphate synthase small subunit N-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-128)
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
YVTN family beta-propeller repeat protein
Activator of Hsp90 ATPase homologue 1-like C-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
SD-repeat containing protein B domain-containing protein
Septum formation-related domain-containing protein
Cytochrome bc1 complex Rieske iron-sulfur subunit
Large ribosomal subunit protein uL6 alpha-beta
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Important for beta-aspartyl-AMP intermediate formation
Cytochrome C biogenesis protein transmembrane
Pyruvate dehydrogenase E1 component middle
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Polymerase/histidinol phosphatase N-terminal
Cytochrome b/b6 N-terminal region profile
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Superoxide dismutase copper/zinc binding
DnaJ homologue subfamily C member 28 conserved
Glutathionylspermidine synthase pre-ATP-grasp-like
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Small ribosomal subunit protein uS4 N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
6-phosphogluconate dehydrogenase C-terminal
DNA replication/recombination mediator RecO N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
NADH:ubiquinone oxidoreductase 30kDa subunit
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
RNA 2-O ribose methyltransferase substrate binding
Phosphatidic acid phosphatase type 2/haloperoxidase
Lactate utilization protein B C-terminal
Putative Flp pilus-assembly TadG-like N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Neutral/alkaline non-lysosomal ceramidase C-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Reversibly protonated during proton transport
Pyrimidine nucleoside phosphorylase C-terminal
Essential for prephenate dehydratase activity
Ribose-phosphate pyrophosphokinase N-terminal
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
LamG-like jellyroll fold domain-containing protein
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Peptidoglycan recognition protein family
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Phosphomannose isomerase type I catalytic
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Glycosyltransferase family 28 N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Tripartite tricarboxylate transporter substrate binding protein
Endonuclease/exonuclease/phosphatase domain-containing protein
Putative glycogen debranching enzyme N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Gram-positive cocci surface proteins LPxTG
PsrA tetracyclin repressor-like C-terminal
Large ribosomal subunit protein uL2 C-terminal
DNA primase/polymerase bifunctional N-terminal
PLD phosphodiesterase domain-containing protein
Glucose-methanol-choline oxidoreductase N-terminal
Phosphocysteine intermediate; for EIIB activity
Nitrite/Sulfite reductase ferredoxin-like
Phosphotransferase system enzyme I N-terminal
Cell wall-active antibiotics response LiaF-like C-terminal
Calcineurin-like phosphoesterase C-terminal
Calcineurin-like phosphoesterase N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
ABC-type glycine betaine transport system substrate-binding
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Resolvase/invertase-type recombinase catalytic
Threonine/serine exporter-like N-terminal
Glycoside-hydrolase family GH114 TIM-barrel
NAD(P) transhydrogenase alpha subunit C-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Glycosyl transferase family 3 N-terminal
Prealbumin-like fold domain-containing protein
SUF system FeS cluster assembly SufBD N-terminal
Myo-inositol-1-phosphate synthase GAPDH-like
NIF system FeS cluster assembly NifU N-terminal
Sporulation transcription regulator WhiA N-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Nicotinate phosphoribosyltransferase N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Glucosamine/galactosamine-6-phosphate isomerase
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Membrane insertase YidC/Oxa/ALB C-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Acetylserotonin O-methyltransferase dimerisation
Anti-sigma-D factor RsdA sigma factor binding region
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Polysaccharide biosynthesis protein CapD-like