Penicillin-binding protein transpeptidase
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Phosphoadenosine phosphosulphate reductase
Cytochrome c-type biogenesis protein CcmF C-terminal
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Glycine cleavage T-protein C-terminal barrel
Aminoacyl-transfer RNA synthetases class-II family profile
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Cell envelope-related transcriptional attenuator
Glucose-methanol-choline oxidoreductase N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Peptidase S9 prolyl oligopeptidase catalytic
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Sporulation transcription regulator WhiA N-terminal
Heat-inducible transcription repressor HrcA C-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
Formamidopyrimidine-DNA glycosylase catalytic
Helix-hairpin-helix DNA-binding motif class 1
DNA primase/polymerase bifunctional N-terminal
Major facilitator superfamily (MFS) profile
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
DNA replication/recombination mediator RecO N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Neutral/alkaline non-lysosomal ceramidase C-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
Bacterial type II secretion system protein E
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Cytochrome C biogenesis protein transmembrane
NADH:ubiquinone oxidoreductase 30kDa subunit
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Alpha-D-phosphohexomutase alpha/beta/alpha
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
N(4)-bis(aminopropyl)spermidine synthase C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Phosphoribosylformylglycinamidine synthase linker
Ribosomal RNA adenine methylase transferase N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Chromosomal replication initiator DnaA C-terminal
Polymerase/histidinol phosphatase N-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Peptidase M1 membrane alanine aminopeptidase
Endonuclease/exonuclease/phosphatase domain-containing protein
Anti-sigma-D factor RsdA sigma factor binding region
Plays an important role in substrate specificity
SGNH hydrolase-type esterase domain-containing protein
Gly-cisPro motif, important for rejection of L-amino acids
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Endoribonuclease L-PSP/chorismate mutase-like
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
YbaK/aminoacyl-tRNA synthetase-associated
NAD(P) transhydrogenase alpha subunit C-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Pyruvate dehydrogenase E1 component middle
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Peptidase C39-like domain-containing protein
Gram-positive cocci surface proteins LPxTG
Translation elongation factor P/YeiP central
Tryptophan synthase beta chain-like PALP
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
ABC transporter substrate-binding protein PnrA-like
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
NIF system FeS cluster assembly NifU N-terminal
HNH/Endo VII superfamily nuclease toxins
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Cytochrome b/b6 N-terminal region profile
ABC-type glycine betaine transport system substrate-binding
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Putative oxidoreductase/dehydrogenase Rossmann-like
Transcription regulator AsnC/Lrp ligand binding
TrbL/VirB6 plasmid conjugal transfer protein
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
O-(5'-phospho-DNA)-tyrosine intermediate
Phosphatidic acid phosphatase type 2/haloperoxidase
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Glycosyltransferase subfamily 4-like N-terminal
Schiff-base intermediate with dihydroxyacetone-P
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Bacterial bifunctional deaminase-reductase C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Heme-copper oxidase subunit III family profile
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Shikimate dehydrogenase substrate binding N-terminal
Prealbumin-like fold domain-containing protein
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Myo-inositol-1-phosphate synthase GAPDH-like
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
PLD phosphodiesterase domain-containing protein
Sodium/calcium exchanger membrane region
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
RNA 2-O ribose methyltransferase substrate binding
Alanyl-transfer RNA synthetases family profile
SUF system FeS cluster assembly SufBD N-terminal
DNA-directed DNA polymerase family A palm
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
PsrA tetracyclin repressor-like C-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Methionyl-tRNA synthetase anticodon-binding
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Transcription elongation factor GreA/GreB C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Prokaryotic-type class I peptide chain release factors
Putative regulatory protein FmdB Zinc ribbon
Actinobacteria/chloroflexi VLRF1 release factor
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Mandelate racemase/muconate lactonizing enzyme C-terminal
Exonuclease VII large subunit C-terminal
Threonine/serine exporter-like N-terminal
6-phosphogluconate dehydrogenase C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Activator of Hsp90 ATPase homologue 1-like C-terminal
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
ATP synthase F1 complex delta/epsilon subunit N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Peptide methionine sulphoxide reductase MsrA
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Cell wall-active antibiotics response LiaF-like C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Prepilin type IV endopeptidase peptidase
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Cytochrome oxidase subunit II copper A binding
Septum formation-related domain-containing protein
Alpha-glycerophosphate oxidase C-terminal
Putative glycogen debranching enzyme N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Peptidoglycan recognition protein family
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
TRAP C4-dicarboxylate transport system permease DctM subunit
Large ribosomal subunit protein uL2 C-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Histidine-specific methyltransferase SAM-dependent
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Glycosyl transferase family 3 N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Involved in ionization of N3 of dUMP, leading to its activation
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Glucosamine/galactosamine-6-phosphate isomerase
Molybdopterin cofactor biosynthesis C (MoaC)
DNA-directed RNA polymerase RpoA/D/Rpb3-type
O-(3'-phospho-DNA)-tyrosine intermediate
Phosphomannose isomerase type I catalytic
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Protein O-mannosyl-transferase C-terminal four TM
Important for beta-aspartyl-AMP intermediate formation
PhoD-like phosphatase metallophosphatase
YVTN family beta-propeller repeat protein
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Polysaccharide biosynthesis protein CapD-like
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Phosphocysteine intermediate; for EIIB activity
Glutathionylspermidine synthase pre-ATP-grasp-like
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
NADH:ubiquinone oxidoreductase-like 20kDa subunit
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
Lactate utilization protein B C-terminal
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Proton acceptor; for glutaminase activity
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
L-seryl-tRNA selenium transferase N-terminal
Cytochrome bc1 complex Rieske iron-sulfur subunit
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
Integral membrane protein YccS N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Reversibly protonated during proton transport
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Transcription elongation factor GreA/GreB N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Small ribosomal subunit protein uS4 N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Signal transduction histidine kinase internal region
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Removed in mature form; by autocatalysis
Large ribosomal subunit protein uL15/eL18
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Adaptive response protein AidB N-terminal
Essential for prephenate dehydratase activity
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Schiff-base intermediate with D-ribose 5-phosphate
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation