Probable transposase IS891/IS1136/IS1341
Type I restriction modification DNA specificity
Transcription factor NikR nickel binding C-terminal
Damage-control phosphatase ARMT1-like metal-binding
Schiff-base intermediate with dihydroxyacetone-P
Large ribosomal subunit protein uL15/eL18
Mannose-6-phosphate isomerase type II C-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Methyl-coenzyme M reductase alpha subunit C-terminal
Methyl-coenzyme M reductase alpha subunit N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Gamma-glutamylcyclotransferase AIG2-like
Aspartate/homoserine dehydrogenase NAD-binding
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
6-phosphogluconate dehydrogenase NADP-binding
H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase C-terminal
Resolvase/invertase-type recombinase catalytic
Polysaccharide biosynthesis protein C-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Removed in mature form; by autocatalysis
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Zn-dependent metallo-hydrolase RNA specificity
CobB/CobQ-like glutamine amidotransferase
Dihydroneopterin aldolase MtpD C-terminal
Large ribosomal subunit protein uL10-like insertion
Aminoacyl-tRNA synthetase class I anticodon-binding
Tryptophan synthase beta chain-like PALP
Pyruvate/ketoisovalerate oxidoreductase catalytic
Formylmethanofuran dehydrogenase subunit E
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Proliferating cell nuclear antigen PCNA C-terminal
Proliferating cell nuclear antigen PCNA N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Molybdopterin cofactor biosynthesis C (MoaC)
NADH:ubiquinone oxidoreductase-like 20kDa subunit
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Urease accessory protein UreH-like transmembrane
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
SAM-dependent methyltransferase TRM5/TYW2-type
Anthranilate synthase component I N-terminal
Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange
Small ribosomal subunit protein uS15 N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
N(4)-bis(aminopropyl)spermidine synthase C-terminal
Phosphoadenosine phosphosulphate reductase
Alpha-D-phosphohexomutase alpha/beta/alpha
Aminoacyl-tRNA synthetase class II (G/ P/ S/T)
Glutamate synthase alpha subunit C-terminal
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Important for beta-aspartyl-AMP intermediate formation
Thiamine pyrophosphate enzyme TPP-binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Tetrahydromethanopterin S-methyltransferase F subunit
Aldehyde ferredoxin oxidoreductase N-terminal
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal
Coenzyme F420 hydrogenase/dehydrogenase beta subunit N-terminal
Thymidylate synthase/dCMP hydroxymethylase
Ribosome maturation protein SDO1/SBDS C-terminal
Ribosome maturation protein SDO1/SBDS N-terminal
Ribosome maturation protein SDO1/SBDS central
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr C-terminal
Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr N-terminal
Major facilitator superfamily (MFS) profile
Aminoacyl-transfer RNA synthetases class-II family profile
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Transcription factor CBF/NF-Y/archaeal histone
Glycosyltransferase subfamily 4-like N-terminal
CO dehydrogenase/acetyl-CoA synthase delta subunit TIM barrel
May act as a substrate filter by repelling compounds with a negatively charged alpha-carboxylate
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Methyl-coenzyme M reductase beta subunit C-terminal
Methyl-coenzyme M reductase beta subunit N-terminal
Spo11/DNA topoisomerase VI subunit A N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Glycoside-hydrolase family GH114 TIM-barrel
6-hydroxymethylpterin diphosphokinase MptE-like
Phosphoribosylformylglycinamidine synthase linker
RNA 3'-terminal phosphate cyclase insert
Sodium/calcium exchanger membrane region
Cytochrome C biogenesis protein transmembrane
Plays an important role in substrate specificity
Phosphatidic acid phosphatase type 2/haloperoxidase
Pyruvate phosphate dikinase AMP/ATP-binding
Alanyl-transfer RNA synthetases family profile
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Glycoside hydrolase family 57 N-terminal
tRNA nucleotidyltransferase substrate binding
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Schiff-base intermediate with D-ribose 5-phosphate
CO dehydrogenase/acetyl-CoA synthase complex beta subunit C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Polymerase/histidinol phosphatase N-terminal
Archaetidylserine decarboxylase alpha chain
Archaetidylserine decarboxylase beta chain
Cleavage (non-hydrolytic); by autocatalysis
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SAMP2)
Carbamoyl-phosphate synthase small subunit N-terminal
Small zinc finger protein HVO-2753-like zinc-binding pocket
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Peptidase A24A-predicted C-terminal archaea
Prepilin type IV endopeptidase peptidase
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Hypoxanthine/guanine phosphoribosyltransferase
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Inosine monophosphate cyclohydrolase-like
Membrane protein 6-pyruvoyl-tetrahydropterin synthase-related
Dinitrogenase iron-molybdenum cofactor biosynthesis
Pseudouridine synthase I TruA alpha/beta
RNA polymerase subunit H/Rpb5 C-terminal
60S ribosome subunit biogenesis protein NIP7 pre-PUA
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
ATPsynthase alpha/beta subunit N-terminal extension
Putative cytidyltransferase-related C-terminal region
Pyrimidine nucleoside phosphorylase C-terminal
Increases nucleophilicity of active site Cys
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Shikimate dehydrogenase substrate binding N-terminal
Type ISP restriction-modification enzyme LLaBIII C-terminal specificity
Small ribosomal subunit protein uS4 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Large ribosomal subunit protein uL2 C-terminal
Proton acceptor; for FBP phosphatase activity
Proton donor/acceptor; for FBP aldolase activity
Schiff-base intermediate with DHAP; for FBP aldolase activity