Schiff-base intermediate with substrate; via pyruvic acid
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
TonB-dependent receptor-like beta-barrel
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
UDP N-acetylglucosamine O-acyltransferase C-terminal
Transposase IS116/IS110/IS902 C-terminal
Glycosyltransferase subfamily 4-like N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Ribose-phosphate pyrophosphokinase N-terminal
Major facilitator superfamily (MFS) profile
Transcription factor NikR nickel binding C-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Glucose-methanol-choline oxidoreductase C-terminal
GxGYxYP putative glycoside hydrolase C-terminal
GxGYxYP putative glycoside hydrolase N-terminal
Transposase IS204/IS1001/IS1096/IS1165 DDE
Transposase IS204/IS1001/IS1096/IS1165 helix-turn-helix
Transposase IS204/IS1001/IS1096/IS1165 zinc-finger
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Glycogen debranching enzyme bacterial and archaeal type N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Type I restriction modification DNA specificity
Tryptophan synthase beta chain-like PALP
Na+/H+ antiporter MnhB subunit-related protein
Polysaccharide biosynthesis protein CapD-like
3-keto-disaccharide hydrolase domain-containing protein
Polysaccharide chain length determinant N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
N6 adenine-specific DNA methyltransferase N-terminal
Polysaccharide biosynthesis protein C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Important for interaction with partner proteins
Solute-binding protein family 3/N-terminal
Abnormal spindle-like microcephaly-associated protein ASH
Important for beta-aspartyl-AMP intermediate formation
Fibronectin type-III domain-containing protein
Phosphatidic acid phosphatase type 2/haloperoxidase
Tetratricopeptide repeat-containing protein
RND efflux pump membrane fusion protein barrel-sandwich
Putative regulatory protein FmdB Zinc ribbon
NIF system FeS cluster assembly NifU C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Schiff-base intermediate with acetaldehyde
TRAP C4-dicarboxylate transport system permease DctM subunit
DNA-directed DNA polymerase family A palm
Aminoacyl-transfer RNA synthetases class-II family profile
Involved in ionization of N3 of dUMP, leading to its activation
nitrite reductase (cytochrome; ammonia-forming)
Por secretion system C-terminal sorting domain-containing protein
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Carboxypeptidase regulatory-like domain-containing protein
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Bacterial type II secretion system protein E
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Phosphomannose isomerase type I catalytic
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
NADH:ubiquinone oxidoreductase 30kDa subunit
NADH:ubiquinone oxidoreductase-like 20kDa subunit
HicB-like antitoxin of toxin-antitoxin system
Phosphoribosylformylglycinamidine synthase linker
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
ATP synthase F1 complex delta/epsilon subunit N-terminal
Flagellar motor switch protein FliN-like C-terminal
Glycosyl transferase family 28 C-terminal
RNA polymerase sigma factor 70 region 4 type 2
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Exonuclease VII large subunit C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
O-(3'-phospho-DNA)-tyrosine intermediate
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
ABC-type uncharacterised transport system
Trigger factor ribosome-binding bacterial
Pyruvate/ketoisovalerate oxidoreductase catalytic
Thiamine pyrophosphate enzyme TPP-binding
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Cytochrome b561 bacterial/Ni-hydrogenase
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Peptidoglycan recognition protein family
Dinitrogenase iron-molybdenum cofactor biosynthesis
Glycosyl hydrolase-like 10 domain-containing protein
Small ribosomal subunit protein uS4 N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Pyruvate phosphate dikinase AMP/ATP-binding
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Inosine/uridine-preferring nucleoside hydrolase
Peptidase MA-like domain-containing protein
Type IX secretion system protein PorV domain-containing protein
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Peptidase S9 prolyl oligopeptidase catalytic
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Carbamoyl-phosphate synthase small subunit N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Lipocalin-like domain-containing protein
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Large ribosomal subunit protein uL15/eL18
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
ssDNA thymidine ADP-ribosyltransferase DarT
Survival protein SurE-like phosphatase/nucleotidase
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Thrombospondin type 3 repeat-containing protein
NIF system FeS cluster assembly NifU N-terminal
Helix-hairpin-helix DNA-binding motif class 1
DNA-directed RNA polymerase RpoA/D/Rpb3-type
S-adenosyl-L-homocysteine hydrolase NAD binding
Ribosomal RNA adenine methylase transferase N-terminal
DNA mismatch repair proteins mutS family
Beta-hexosaminidase bacterial type N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Inner membrane protein YgaP-like transmembrane
Non-canonical purine NTP phosphatase/PRRC1
Alpha-D-phosphohexomutase alpha/beta/alpha
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Polymerase/histidinol phosphatase N-terminal
Alanyl-transfer RNA synthetases family profile
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Choloylglycine hydrolase/NAAA C-terminal
Flagellar Assembly Protein A N-terminal region
Putative oxidoreductase/dehydrogenase Rossmann-like
Prokaryotic-type class I peptide chain release factors
RNA 2-O ribose methyltransferase substrate binding
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Alpha-amylase/4-alpha-glucanotransferase C-terminal
Alpha-amylase/4-alpha-glucanotransferase central
Glycoside hydrolase family 57 N-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Phosphotransferase system enzyme I N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Heme-copper oxidase subunit III family profile
Outer membrane protein beta-barrel domain-containing protein
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Plays an important role in substrate specificity
Ribosome maturation factor RimP N-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Penicillin-binding protein transpeptidase
Sodium/calcium exchanger membrane region
Gly-cisPro motif, important for rejection of L-amino acids
Anthranilate synthase component I N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Alpha-glycerophosphate oxidase C-terminal
Cysteine sulfenic acid (-SOH) intermediate
Thiamin pyrophosphokinase thiamin-binding
Glycosyl hydrolases family 2 sugar binding
NAD(P) transhydrogenase alpha subunit C-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
RNA binding; important for wobble base 34 recognition
Sporulation stage II protein D amidase enhancer LytB N-terminal
Release factor glutamine methyltransferase N-terminal
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Membrane protein involved in aromatic hydrocarbon degradation
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Polyribonucleotide 5'-hydroxyl-kinase Clp1 P-loop
Chromosomal replication initiator DnaA C-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Glycosyltransferase family 28 N-terminal
ABC-type transport auxiliary lipoprotein component
Pyrimidine nucleoside phosphorylase C-terminal
Saccharopine dehydrogenase-like C-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Type II restriction enzyme and methyltransferase RM.Eco57I-like
Aspartate/homoserine dehydrogenase NAD-binding
Formamidopyrimidine-DNA glycosylase catalytic
Transition state stabilizer; via amide nitrogen
Pseudouridine synthase I TruA alpha/beta
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Water stress and hypersensitive response
F420-non-reducing hydrogenase iron-sulfur subunit D
Mannose-6-phosphate isomerase type II C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Peptidase M1 membrane alanine aminopeptidase
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Organic solvent tolerance-like N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
YbaK/aminoacyl-tRNA synthetase-associated
ATP-dependent DNA helicase RecG C-terminal
Zn-dependent metallo-hydrolase RNA specificity
Sugar fermentation stimulation protein C-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Glycine cleavage T-protein C-terminal barrel
Gamma-butyrobetaine hydroxylase-like N-terminal
DNA replication/recombination mediator RecO N-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
LPS-assembly protein LptD central domain-containing protein
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
Helix-hairpin-helix motif-containing protein
Pyruvate dehydrogenase E1 component middle
Type III restriction enzyme C-terminal endonuclease
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Formiminotransferase C-terminal subdomain
Formiminotransferase N-terminal subdomain
Glycosyl-hydrolase 97 C-terminal oligomerisation
Schiff-base intermediate with D-ribose 5-phosphate
Translation elongation factor P/YeiP central
Glycosyl transferase family 3 N-terminal
Secretion system C-terminal sorting domain-containing protein
CRISPR-associated protein Cas6 C-terminal
Large ribosomal subunit protein uL2 C-terminal
Prepilin type IV endopeptidase peptidase
Flagella basal body P-ring formation protein FlgA
Flagella basal body P-ring formation protein FlgA C-terminal
Damage-control phosphatase ARMT1-like metal-binding
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile