Thiamine pyrophosphate enzyme TPP-binding
Myo-inositol-1-phosphate synthase GAPDH-like
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Major facilitator superfamily (MFS) profile
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Peptidase M1 membrane alanine aminopeptidase
Phosphoribosylformylglycinamidine synthase linker
Pyridoxamine 5'-phosphate oxidase putative
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Penicillin-binding protein transpeptidase
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
ATP synthase F1 complex delta/epsilon subunit N-terminal
4'-phosphopantetheinyl transferase N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Ribose-phosphate pyrophosphokinase N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Helix-hairpin-helix DNA-binding motif class 1
Cytochrome b/b6 N-terminal region profile
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Tryptophan synthase beta chain-like PALP
PsrA tetracyclin repressor-like C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Thiolase-like protein type 1 additional C-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Histidine-specific methyltransferase SAM-dependent
RNA 2-O ribose methyltransferase substrate binding
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Pyridine nucleotide-disulphide oxidoreductase dimerisation
NADH:ubiquinone oxidoreductase-like 20kDa subunit
RNA polymerase sigma factor 70 region 4 type 2
Heme-copper oxidase subunit III family profile
Gamma-glutamylcyclotransferase AIG2-like
Glycosyltransferase subfamily 4-like N-terminal
Resolvase/invertase-type recombinase catalytic
Cation-transporting P-type ATPase C-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Glycosyl transferase family 28 C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Plays an important role in substrate specificity
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Interaction with polymerase core subunit RpoC
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Anthranilate synthase component I N-terminal
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Important for beta-aspartyl-AMP intermediate formation
Prokaryotic-type class I peptide chain release factors
Membrane insertase YidC/Oxa/ALB C-terminal
Polymerase/histidinol phosphatase N-terminal
Alanine and proline-rich secreted protein Apa
Mandelate racemase/muconate lactonizing enzyme C-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Bacterial bifunctional deaminase-reductase C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Small ribosomal subunit protein uS4 N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Acyltransferase MbtK/IucB-like conserved
Gly-cisPro motif, important for rejection of L-amino acids
Schiff-base intermediate with acetaldehyde
Putative oxidoreductase/dehydrogenase Rossmann-like
NIF system FeS cluster assembly NifU N-terminal
6-phosphogluconate dehydrogenase C-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Thioredoxin-like fold domain-containing protein
Peptide methionine sulphoxide reductase MsrA
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Alpha-glycerophosphate oxidase C-terminal
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Putative Flp pilus-assembly TadG-like N-terminal
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
L-seryl-tRNA selenium transferase N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Important for substrate specificity; cannot use PPi as phosphoryl donor
Haemophore haem-binding domain-containing protein
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
Reversibly protonated during proton transport
Quercetin 2,3-dioxygenase C-terminal cupin
2,4-diaminopentanoate dehydrogenase C-terminal
Dihydrodipicolinate reductase N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Nitrite/Sulfite reductase ferredoxin-like
Putative regulatory protein FmdB Zinc ribbon
Prepilin type IV endopeptidase peptidase
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Phosphatidic acid phosphatase type 2/haloperoxidase
Metallo-beta-lactamase domain-containing protein
Cytochrome C biogenesis protein transmembrane
Thiosulphate:quinone oxidoreductase small subunit DoxA
DNA primase/polymerase bifunctional N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Chromosomal replication initiator DnaA C-terminal
Transcription elongation factor GreA/GreB C-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Bacterial type II secretion system protein E
Thymidylate synthase/dCMP hydroxymethylase
Phosphomannose isomerase type I catalytic
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Choloylglycine hydrolase/NAAA C-terminal
Glycine cleavage T-protein C-terminal barrel
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Dihydrodipicolinate reductase C-terminal
Pyrroline-5-carboxylate reductase dimerisation
Could be important to modulate the pK values of the two catalytic cysteine residues
Translation elongation factor P/YeiP central
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Resuscitation-promoting factor core lysozyme-like
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Large ribosomal subunit protein uL2 C-terminal
PEP-CTERM sorting domain-containing protein
Proton acceptor; for glutaminase activity
Peptidase S9 prolyl oligopeptidase catalytic
SUF system FeS cluster assembly SufBD N-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Glycoside hydrolase family 5 domain-containing protein
3-beta hydroxysteroid dehydrogenase/isomerase
N6 adenine-specific DNA methyltransferase N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
O-(3'-phospho-DNA)-tyrosine intermediate
Aconitase A/isopropylmalate dehydratase small subunit swivel
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Alanyl-transfer RNA synthetases family profile
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Moves into active site upon enzyme activation, plays a role in electron transfer
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminal
Transmembrane alanine and glycine rich protein
Microcin J25-processing protein McjB C-terminal
DNA replication/recombination mediator RecO N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
DNA-directed DNA polymerase family A palm
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Molybdopterin cofactor biosynthesis C (MoaC)
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
CobB/CobQ-like glutamine amidotransferase
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Inosine/uridine-preferring nucleoside hydrolase
Cysteine sulfenic acid (-SOH) intermediate
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Transglycosylase SLT domain-containing protein
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Glucosamine/galactosamine-6-phosphate isomerase
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Involved in ionization of N3 of dUMP, leading to its activation
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Exonuclease VII large subunit C-terminal
Transcription elongation factor GreA/GreB N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Arabinofuranosyltransferase AftA C-terminal
Arabinofuranosyltransferase AftA N-terminal