Major facilitator superfamily (MFS) profile
Prepilin type IV endopeptidase peptidase
Acyl-CoA dehydrogenase/oxidase C-terminal
Ricin B lectin domain-containing protein
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Prokaryotic-type class I peptide chain release factors
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Phosphoadenosine phosphosulphate reductase
Alpha-carbonic anhydrase domain-containing protein
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Peptide methionine sulphoxide reductase MsrA
Acyl-CoA dehydrogenase/oxidase N-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Erythromycin biosynthesis protein CIII-like central
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Peptidase S9 prolyl oligopeptidase catalytic
Pyridoxamine 5'-phosphate oxidase putative
Acetylserotonin O-methyltransferase dimerisation
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Methionyl-tRNA synthetase anticodon-binding
Damage-control phosphatase ARMT1-like metal-binding
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
Alanyl-transfer RNA synthetases family profile
Glycosyltransferase subfamily 4-like N-terminal
Major facilitator superfamily (MFS) profile domain-containing protein
Polymerase/histidinol phosphatase N-terminal
Sugar ABC transporter substrate-binding protein
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
4'-phosphopantetheinyl transferase N-terminal
Gram-positive cocci surface proteins LPxTG domain-containing protein
Large ribosomal subunit protein uL2 C-terminal
SD-repeat containing protein B domain-containing protein
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
YbaK/aminoacyl-tRNA synthetase-associated
FAD-dependent oxidoreductase 2 FAD binding
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Membrane insertase YidC/Oxa/ALB C-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Bacterial type II secretion system protein E
Alpha-glycerophosphate oxidase C-terminal
Tryptophan synthase beta chain-like PALP
O-(3'-phospho-DNA)-tyrosine intermediate
Aminoacyl-transfer RNA synthetases class-II family profile
Peptidase S8/S53 domain-containing protein
Beta-glucuronidase C-terminal domain-containing protein
Butirosin biosynthesis protein H N-terminal
Isoglutamyl lysine isopeptide (Glu-Lys) (interchain with K-? in acceptor proteins)
NIF system FeS cluster assembly NifU N-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
vWA-MoxR associated protein middle region 2
L-seryl-tRNA selenium transferase N-terminal
Amidohydrolase-related domain-containing protein
Penicillin-binding protein transpeptidase
NAD(P) transhydrogenase alpha subunit C-terminal
Shikimate dehydrogenase substrate binding N-terminal
Survival protein SurE-like phosphatase/nucleotidase
Important for beta-aspartyl-AMP intermediate formation
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Alpha-D-phosphohexomutase alpha/beta/alpha
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
Peptidase C-terminal archaeal/bacterial domain-containing protein
S-adenosyl-L-homocysteine hydrolase NAD binding
DNA-directed DNA polymerase family A palm
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Fe/B12 periplasmic-binding domain-containing protein
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Gly-cisPro motif, important for rejection of L-amino acids
ABC transporter substrate-binding protein
Solute-binding protein family 3/N-terminal
CobB/CobQ-like glutamine amidotransferase
Large ribosomal subunit protein uL6 alpha-beta
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
PhoD-like phosphatase metallophosphatase
Heat-inducible transcription repressor HrcA C-terminal
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Xaa-Pro dipeptidyl-peptidase C-terminal domain-containing protein
Transcription regulator AsnC/Lrp ligand binding
Thiopeptide-type bacteriocin biosynthesis
Cobalamin-independent methionine synthase MetE N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Phosphatidic acid phosphatase type 2/haloperoxidase
ABC-type glycine betaine transport system substrate-binding
Molybdopterin cofactor biosynthesis C (MoaC)
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Inosine/uridine-preferring nucleoside hydrolase
Pyrroline-5-carboxylate reductase catalytic N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
AB hydrolase-1 domain-containing protein
Beta-hexosaminidase bacterial type N-terminal
Peptidase M1 membrane alanine aminopeptidase
Methylguanine DNA methyltransferase ribonuclease-like
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
O-(5'-phospho-DNA)-tyrosine intermediate
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Nucleophile; cysteine thiosulfonate intermediate
Schiff-base intermediate with D-ribose 5-phosphate
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Peptidase C39-like domain-containing protein
Formamidopyrimidine-DNA glycosylase catalytic
Activator of Hsp90 ATPase homologue 1-like C-terminal
Cell envelope-related transcriptional attenuator
1,4-alpha-glucan branching enzyme C-terminal
Glycoside hydrolase family 57 N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
RNA 2-O ribose methyltransferase substrate binding
Right handed beta helix domain-containing protein
Glycosyl transferase family 3 N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Removed in mature form; by autocatalysis
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Endoribonuclease L-PSP/chorismate mutase-like
Translation elongation factor SelB winged helix type 3
Glucose-methanol-choline oxidoreductase N-terminal
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Pyrimidine nucleoside phosphorylase C-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
6-phosphogluconate dehydrogenase C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Glucose-methanol-choline oxidoreductase C-terminal
N-acetylmuramoyl-L-alanine amidase domain-containing protein
DNA topoisomerase I catalytic core eukaryotic-type
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Solute-binding protein family 5 domain-containing protein
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Aminopeptidase N-like N-terminal domain-containing protein
Arabinofuranosyltransferase AftA C-terminal
Arabinofuranosyltransferase AftA N-terminal
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Endonuclease/exonuclease/phosphatase domain-containing protein
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
Plays an important role in substrate specificity
Involved in ionization of N3 of dUMP, leading to its activation
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Glycine cleavage T-protein C-terminal barrel
SMP-30/Gluconolactonase/LRE-like region domain-containing protein
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Phosphocysteine intermediate; for EIIB activity
Mannose-6-phosphate isomerase type II C-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit FMN-binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Anthranilate synthase component I N-terminal
ABC transporter substrate-binding protein PnrA-like
ABC transporter substrate-binding protein PnrA-like domain-containing protein
Microcystin LR degradation protein MlrC C-terminal
Microcystin LR degradation protein MlrC N-terminal
Styrene monooxygenase StyA putative substrate binding
Adaptive response protein AidB N-terminal
Probable transposase IS891/IS1136/IS1341
Protein-arginine deiminase C-terminal domain-containing protein
ATP synthase F1 complex delta/epsilon subunit N-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
N6 adenine-specific DNA methyltransferase N-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Chromosomal replication initiator DnaA C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Tat pathway signal sequence domain protein
Heme-copper oxidase subunit III family profile
Streptomyces killer toxin-like beta/gamma crystallin
Streptomyces killer toxin-like beta/gamma crystallin domain-containing protein
Ribosomal RNA adenine methylase transferase N-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-128)
Resolvase/invertase-type recombinase catalytic
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Sodium/calcium exchanger membrane region
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
SGNH hydrolase-type esterase domain-containing protein
Pyrroline-5-carboxylate reductase dimerisation
vWA-MoxR associated protein middle region 0
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Lactate utilization protein B C-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
Myo-inositol-1-phosphate synthase GAPDH-like
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Molybdenum cofactor biosynthesis protein F N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Ionotropic glutamate receptor C-terminal
Small ribosomal subunit protein uS4 N-terminal
Beta-lactamase-related domain-containing protein
Cytochrome b/b6 N-terminal region profile
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Phosphatidylinositol-specific phospholipase C X
Glucose/Sorbosone dehydrogenase domain-containing protein
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Peptidase M15B domain-containing protein
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Moybdenum cofactor oxidoreductase dimerisation
Gamma-glutamylcyclotransferase AIG2-like
NADH:ubiquinone oxidoreductase-like 20kDa subunit
PsrA tetracyclin repressor-like C-terminal
Sporulation transcription regulator WhiA N-terminal
Interaction with polymerase core subunit RpoC
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Essential for prephenate dehydratase activity
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein
Membrane fusion protein biotin-lipoyl like
Cytochrome C biogenesis protein transmembrane
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
N,N-dimethylformamidase beta subunit-like C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
DNA primase/polymerase bifunctional N-terminal
Chitin-binding type-2 domain-containing protein
Transcriptional regulator LacI/GalR-like sensor
Pyruvate dehydrogenase E1 component middle
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Increases nucleophilicity of active site Cys
SUF system FeS cluster assembly SufBD N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
LamG-like jellyroll fold domain-containing protein
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Schiff-base intermediate with dihydroxyacetone-P
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Exonuclease VII large subunit C-terminal
Amidohydrolase 3 domain-containing protein
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Release factor glutamine methyltransferase N-terminal
2,4-diaminopentanoate dehydrogenase C-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
FAD-binding PCMH-type domain-containing protein
Protein O-mannosyl-transferase C-terminal four TM
Histidine-specific methyltransferase SAM-dependent
Transglycosylase SLT domain-containing protein
Peptidoglycan recognition protein family
Peptidoglycan recognition protein family domain-containing protein
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Proton acceptor; for glutaminase activity
Peptidase M14 carboxypeptidase A domain-containing protein
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Ribose-phosphate pyrophosphokinase N-terminal
Alpha-L-arabinofuranosidase B arabinose-binding
Alpha-L-arabinofuranosidase B arabinose-binding domain-containing protein
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Metallo-beta-lactamase domain-containing protein
Phosphatidylglycerol lysyltransferase C-terminal
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
DNA replication/recombination mediator RecO N-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Alpha galactosidase C-terminal beta sandwich
Putative oxidoreductase/dehydrogenase Rossmann-like
Septum formation-related domain-containing protein
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Squalene cyclase C-terminal domain-containing protein
Subtilisin inhibitor domain-containing protein
Phosphomannose isomerase type I catalytic
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
ABC transmembrane type-1 domain-containing protein
Phosphotransferase system enzyme I N-terminal
Thymidylate synthase/dCMP hydroxymethylase
Heavy metal-binding domain-containing protein
Adenylyl/Guanylyl and SMODS C-terminal sensor
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
Phosphoribosylformylglycinamidine synthase linker
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-108)
Fungal lipase-like domain-containing protein
L,D-transpeptidase catalytic domain-containing protein
Tail specific protease domain-containing protein
Cytochrome oxidase subunit II copper A binding
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal