Major facilitator superfamily (MFS) profile
Pyruvate phosphate dikinase AMP/ATP-binding
Transposase IS116/IS110/IS902 C-terminal
DNA mismatch repair proteins mutS family
RNA 2-O ribose methyltransferase substrate binding
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Peptide methionine sulphoxide reductase MsrA
DNA-directed DNA polymerase family A palm
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Schiff-base intermediate with D-ribose 5-phosphate
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Alpha-D-phosphohexomutase alpha/beta/alpha
Pyridine nucleotide-disulphide oxidoreductase dimerisation
HicB-like antitoxin of toxin-antitoxin system
Sporulation stage II protein D amidase enhancer LytB N-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Cell envelope-related transcriptional attenuator
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Phosphomannose isomerase type I catalytic
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Schiff-base intermediate with substrate; via pyruvic acid
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Large ribosomal subunit protein uL6 alpha-beta
DNA replication/recombination mediator RecO N-terminal
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Could be important to modulate the pK values of the two catalytic cysteine residues
Phosphotransferase system enzyme I N-terminal
Translation elongation factor P/YeiP central
Type III secretion system flagellar brake protein YcgR PilZN
Glycosyltransferase subfamily 4-like N-terminal
Proton acceptor; for glutaminase activity
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Release factor glutamine methyltransferase N-terminal
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
Plays an important role in substrate specificity
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Large ribosomal subunit protein uL15/eL18
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
NADH-rubredoxin oxidoreductase C-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Polymerase/histidinol phosphatase N-terminal
RNA binding; important for wobble base 34 recognition
NADH-ubiquinone oxidoreductase 51kDa subunit FMN-binding
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Thiamine pyrophosphate enzyme TPP-binding
Polysaccharide biosynthesis protein C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Pyruvate/ketoisovalerate oxidoreductase catalytic
Aminoacyl-transfer RNA synthetases class-II family profile
SUF system FeS cluster assembly SufBD N-terminal
Cation-transporting P-type ATPase N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
ABC transporter substrate-binding protein PnrA-like
Important for interaction with partner proteins
Important for beta-aspartyl-AMP intermediate formation
Inner membrane protein YgaP-like transmembrane
Tryptophan synthase beta chain-like PALP
RDXXRA motif of the pArg binding pocket involved in allosteric regulation
Signal recognition particle SRP54 helical bundle
Ribose-phosphate pyrophosphokinase N-terminal
Anthranilate synthase component I N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Flagellar motor switch protein FliN-like C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Signal transduction histidine kinase osmosensitive K+ channel sensor N-terminal
Threonine/serine exporter-like N-terminal
Large ribosomal subunit protein uL2 C-terminal
Sporulation transcription regulator WhiA N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
6-phosphogluconate dehydrogenase NADP-binding
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Helix-hairpin-helix DNA-binding motif class 1
Putative amidase domain-containing protein
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
6-phosphogluconate dehydrogenase C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Helix-turn-helix conjugative transposon-like
Involved in allosteric activation by GTP
Solute-binding protein family 3/N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Sugar fermentation stimulation protein C-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase N-terminal
Cytochrome C biogenesis protein transmembrane
Flagellar Assembly Protein A N-terminal region
Membrane fusion protein biotin-lipoyl like
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Positions MEP for the nucleophilic attack
Small ribosomal subunit protein uS4 N-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Magnesium transporter MgtE intracellular
O-(5'-phospho-DNA)-tyrosine intermediate
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Transcription factor NikR nickel binding C-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
D-galactarate/Altronate dehydratase C-terminal
Chromosomal replication initiator DnaA C-terminal
Gamma-glutamylcyclotransferase AIG2-like
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Phosphocysteine intermediate; for EIIB activity
Glycosyl transferase family 3 N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Penicillin-binding protein transpeptidase
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Dinitrogenase iron-molybdenum cofactor biosynthesis
N-terminal domain of peptidoglycan hydrolase CwlO-containing protein
Conserved hypothetical protein CHP02679 N terminus
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Phosphatidylglycerol lysyltransferase C-terminal
Heat-inducible transcription repressor HrcA C-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Photosynthesis system II assembly factor Ycf48/Hcf136-like domain-containing protein
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
NIF system FeS cluster assembly NifU N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Prepilin type IV endopeptidase peptidase
CobB/CobQ-like glutamine amidotransferase
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Polysaccharide biosynthesis protein CapD-like
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Schiff-base intermediate with acetaldehyde
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Large ribosomal subunit protein uL30-like ferredoxin-like fold
UDP-glucose/GDP-mannose dehydrogenase C-terminal
DNA polymerase III delta subunit C-terminal
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Gly-cisPro motif, important for rejection of L-amino acids
Polysaccharide chain length determinant N-terminal
Glycosyl-hydrolase family 116 N-terminal
Glycosyl-hydrolase family 116 catalytic region
Reversibly protonated during proton transport
Global transcriptional regulator CodY C-terminal
Global transcriptional regulator CodY N-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
6-hydroxymethylpterin diphosphokinase MptE-like
Thiamin pyrophosphokinase thiamin-binding
Peptidase C39-like domain-containing protein
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Bacterial type II secretion system protein E
Exonuclease VII large subunit C-terminal
Sporulation stage IV protein A C-terminal
Pyruvate ferredoxin oxidoreductase beta subunit C-terminal
Putative oxidoreductase/dehydrogenase Rossmann-like
Ionotropic glutamate receptor C-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Survival protein SurE-like phosphatase/nucleotidase
Manganese/iron superoxide dismutase C-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Formiminotransferase C-terminal subdomain
Formiminotransferase N-terminal subdomain
Increases nucleophilicity of active site Cys
Diacylglycerol glucosyltransferase N-terminal
Glycosyl transferase family 28 C-terminal
NIF system FeS cluster assembly NifU C-terminal
Glycosyltransferase family 28 N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Prokaryotic-type class I peptide chain release factors
Glutamate synthase alpha subunit C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
ABC-type uncharacterised transport system
Flagellar hook-length control protein-like C-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Alanyl-transfer RNA synthetases family profile
ATP synthase F1 complex delta/epsilon subunit N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Peptidase M1 membrane alanine aminopeptidase
Mandelate racemase/muconate lactonizing enzyme C-terminal
Photosynthesis system II assembly factor Ycf48/Hcf136-like
Phosphoribosylformylglycinamidine synthase linker
Damage-control phosphatase ARMT1-like metal-binding
Glucosamine/galactosamine-6-phosphate isomerase