NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Release factor glutamine methyltransferase N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Glycosyltransferase subfamily 4-like N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Galactofuranosyltransferase GlfT2 N-terminal
Galactofuranosyltransferase-2 C-terminal
Major facilitator superfamily (MFS) profile
Haemophore haem-binding domain-containing protein
Glycosyltransferase family 28 N-terminal
Cytochrome b/b6 N-terminal region profile
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Penicillin-binding protein transpeptidase
Glucosamine/galactosamine-6-phosphate isomerase
Alpha-D-phosphohexomutase alpha/beta/alpha
Phosphatidylglycerol lysyltransferase C-terminal
DNA-directed DNA polymerase family A palm
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Nicotinate phosphoribosyltransferase N-terminal
Quinolinate phosphoribosyl transferase C-terminal
FAD-dependent oxidoreductase 2 FAD binding
Acyl-CoA dehydrogenase/oxidase N-terminal
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Transposase IS204/IS1001/IS1096/IS1165 DDE
Transposase IS204/IS1001/IS1096/IS1165 helix-turn-helix
Transposase IS204/IS1001/IS1096/IS1165 zinc-finger
Pyridoxamine 5'-phosphate oxidase putative
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Polysaccharide biosynthesis protein C-terminal
Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
Tryptophan synthase beta chain-like PALP
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Peptidase M1 membrane alanine aminopeptidase
Glucose-methanol-choline oxidoreductase N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
DNA-directed RNA polymerase RpoA/D/Rpb3-type
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Important for substrate specificity; cannot use PPi as phosphoryl donor
Alanyl-transfer RNA synthetases family profile
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
PknH-like extracellular domain-containing protein
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Prokaryotic-type class I peptide chain release factors
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Superoxide dismutase copper/zinc binding
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
RNA polymerase sigma factor 70 region 4 type 2
Threonine/serine exporter-like N-terminal
Large ribosomal subunit protein uL15/eL18
Anthranilate synthase component I N-terminal
Protein O-mannosyl-transferase C-terminal four TM
Schiff-base intermediate with substrate; via topaquinone
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Small ribosomal subunit protein uS4 N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
RNA 2-O ribose methyltransferase substrate binding
Putative oxidoreductase/dehydrogenase Rossmann-like
Translation elongation factor P/YeiP central
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Cell envelope-related transcriptional attenuator
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Shikimate dehydrogenase substrate binding N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
NAD(P) transhydrogenase alpha subunit C-terminal
Phosphoadenosine phosphosulphate reductase
CobB/CobQ-like glutamine amidotransferase
Peptide methionine sulphoxide reductase MsrA
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Type 2A encapsulin shell protein SrpI-like
Aminoacyl-transfer RNA synthetases class-II family profile
Polymerase/histidinol phosphatase N-terminal
Beta-lactamase-related domain-containing protein
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
6-phosphogluconate dehydrogenase C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Chromosomal replication initiator DnaA C-terminal
Cytochrome oxidase subunit II copper A binding
O-(5'-phospho-DNA)-tyrosine intermediate
Pyrimidine nucleoside phosphorylase C-terminal
Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Na+/H+ antiporter MnhB subunit-related protein
Quinolinate phosphoribosyl transferase N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
2,4-diaminopentanoate dehydrogenase C-terminal
Dihydrodipicolinate reductase N-terminal
Solute-binding protein family 3/N-terminal
Adaptive response protein AidB N-terminal
Sodium/calcium exchanger membrane region
O-(3'-phospho-DNA)-tyrosine intermediate
Essential for prephenate dehydratase activity
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Butirosin biosynthesis protein H N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Putative regulatory protein FmdB Zinc ribbon
Formamidopyrimidine-DNA glycosylase catalytic
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Helix-hairpin-helix DNA-binding motif class 1
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Resolvase/invertase-type recombinase catalytic
DNA primase/polymerase bifunctional N-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Peptidoglycan recognition protein family
Ribosomal RNA adenine methylase transferase N-terminal
Plays an important role in substrate specificity
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Acyltransferase MbtK/IucB-like conserved
Phosphoribosylformylglycinamidine synthase linker
Resuscitation-promoting factor core lysozyme-like
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Reversibly protonated during proton transport
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Phosphatidic acid phosphatase type 2/haloperoxidase
Styrene monooxygenase StyA putative substrate binding
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Exonuclease VII large subunit C-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Alpha-glycerophosphate oxidase C-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Nitrite/Sulfite reductase ferredoxin-like
Methionyl-tRNA synthetase anticodon-binding
Pyruvate dehydrogenase E1 component middle
DNA replication/recombination mediator RecO N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Large ribosomal subunit protein uL6 alpha-beta
Tetracyclin repressor-like C-terminal group 31
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Saccharopine dehydrogenase-like C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Large ribosomal subunit protein uL2 C-terminal
Thiosulphate:quinone oxidoreductase small subunit DoxA
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
ABC-type glycine betaine transport system substrate-binding
Gamma-glutamylcyclotransferase AIG2-like
Important for beta-aspartyl-AMP intermediate formation
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
YbaK/aminoacyl-tRNA synthetase-associated
NADH-rubredoxin oxidoreductase C-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
Prepilin type IV endopeptidase peptidase
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
Cell wall-active antibiotics response LiaF-like C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Phosphomannose isomerase type I catalytic
Cysteine sulfenic acid (-SOH) intermediate
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
PhoD-like phosphatase metallophosphatase
Thymidylate synthase/dCMP hydroxymethylase
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Aminoacyl-tRNA synthetase class I anticodon-binding
Mandelate racemase/muconate lactonizing enzyme C-terminal
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Glucose-methanol-choline oxidoreductase C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
DNA polymerase III beta sliding clamp central
Cobalamin-independent methionine synthase MetE N-terminal
Glycosyl transferase family 3 N-terminal
Methylguanine DNA methyltransferase ribonuclease-like
NIF system FeS cluster assembly NifU N-terminal
Glycine cleavage T-protein C-terminal barrel
Pseudouridine synthase I TruA alpha/beta
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-108)
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Thiolase-like protein type 1 additional C-terminal
Heat-inducible transcription repressor HrcA C-terminal
Glycosyl transferase family 28 C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Myo-inositol-1-phosphate synthase GAPDH-like
Cytochrome C biogenesis protein transmembrane
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Nucleophile; cysteine thiosulfonate intermediate
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Solute-binding protein family 5 domain-containing protein
ATP synthase F1 complex delta/epsilon subunit N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Metallo-beta-lactamase superfamily protein,putative
Heme-copper oxidase subunit III family profile
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Arabinofuranosyltransferase AftA C-terminal
Arabinofuranosyltransferase AftA N-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Schiff-base intermediate with D-ribose 5-phosphate
Transcription regulator AsnC/Lrp ligand binding
Anti-sigma-D factor RsdA sigma factor binding region
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Involved in ionization of N3 of dUMP, leading to its activation
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Inosine/uridine-preferring nucleoside hydrolase
Gly-cisPro motif, important for rejection of L-amino acids
Quercetin 2,3-dioxygenase C-terminal cupin
Moves into active site upon enzyme activation, plays a role in electron transfer
Schiff-base intermediate with acetaldehyde
Endoribonuclease L-PSP/chorismate mutase-like
2-isopropylmalate synthase LeuA allosteric (dimerisation)
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Bacterial type II secretion system protein E
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Alpha galactosidase C-terminal beta sandwich
Ribosome maturation factor RimP N-terminal