Pyruvate phosphate dikinase AMP/ATP-binding
Penicillin-binding protein transpeptidase
NADH:ubiquinone oxidoreductase-like 20kDa subunit
CO dehydrogenase/acetyl-CoA synthase delta subunit TIM barrel
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Choloylglycine hydrolase/NAAA C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Formiminotransferase C-terminal subdomain
Formiminotransferase N-terminal subdomain
HicB-like antitoxin of toxin-antitoxin system
Signal transduction histidine kinase internal region
RNA polymerase sigma factor 70 region 4 type 2
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Polymerase/histidinol phosphatase N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Cytochrome C biogenesis protein transmembrane
Glycosyltransferase subfamily 4-like N-terminal
NADH-ubiquinone oxidoreductase 51kDa subunit FMN-binding
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Chromosomal replication initiator DnaA C-terminal
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Dinitrogenase iron-molybdenum cofactor biosynthesis
Tryptophan synthase beta chain-like PALP
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
5-glutamyl coenzyme A thioester intermediate
Important for autoinhibition of adenylyltransferase activity
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Could play a key role in the communication between the regulatory and the substrate sites
Could be important to modulate the pK values of the two catalytic cysteine residues
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Involved in ionization of N3 of dUMP, leading to its activation
UDP-glucose/GDP-mannose dehydrogenase dimerisation
nitrite reductase (cytochrome; ammonia-forming)
RND efflux pump membrane fusion protein barrel-sandwich
Major facilitator superfamily (MFS) profile
Sodium/calcium exchanger membrane region
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Alpha-D-phosphohexomutase alpha/beta/alpha
Bacterial type II secretion system protein E
Thiamin pyrophosphokinase thiamin-binding
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Type III secretion system flagellar brake protein YcgR PilZN
Resolvase/invertase-type recombinase catalytic
Diacylglycerol glucosyltransferase N-terminal
Glycosyl transferase family 28 C-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
DNA-directed DNA polymerase family A palm
RDXXRA motif of the pArg binding pocket involved in allosteric regulation
Translation elongation factor P/YeiP central
Flagellar motor switch protein FliN-like C-terminal
Important for interaction with partner proteins
Tetrahaem cytochrome domain-containing protein
Polysaccharide chain length determinant N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Acetyl-CoA hydrolase/transferase C-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Pyruvate/ketoisovalerate oxidoreductase catalytic
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
S-adenosyl-L-homocysteine hydrolase NAD binding
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Acetyl-CoA dehydrogenase-like C-terminal
Saccharopine dehydrogenase-like C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Transposase IS116/IS110/IS902 C-terminal
Methylaspartate ammonia-lyase C-terminal
Methylaspartate ammonia-lyase N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Ribose-phosphate pyrophosphokinase N-terminal
F420-non-reducing hydrogenase iron-sulfur subunit D
Putative regulatory protein FmdB Zinc ribbon
Dipicolinate synthase subunit A N-terminal
Membrane fusion protein biotin-lipoyl like
Reversibly protonated during proton transport
Type I restriction modification DNA specificity
DNA mismatch repair proteins mutS family
Release factor glutamine methyltransferase N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-96)
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Solute-binding protein family 3/N-terminal
DNA replication/recombination mediator RecO N-terminal
Carbohydrate-binding domain-containing protein
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Aminoacyl-transfer RNA synthetases class-II family profile
Sporulation stage II protein D amidase enhancer LytB N-terminal
Homocysteine biosynthesis enzyme sulfur-incorporation
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Large ribosomal subunit protein uL15/eL18
Cell envelope-related transcriptional attenuator
Pyridoxamine 5'-phosphate oxidase putative
Global transcriptional regulator CodY C-terminal
Global transcriptional regulator CodY N-terminal
NIF system FeS cluster assembly NifU N-terminal
Polysaccharide biosynthesis protein CapD-like
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Carbamoyl-phosphate synthase small subunit N-terminal
Glycine cleavage T-protein C-terminal barrel
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Nitrite/Sulfite reductase ferredoxin-like
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Lysidine-tRNA(Ile) synthetase C-terminal
Thiamine pyrophosphate enzyme TPP-binding
Glycosyl transferase family 3 N-terminal
Type I restriction enzyme R protein N-terminal
tRNA pseudouridylate synthase B C-terminal
Membrane iron-sulfur containing protein FtrD-like
Inosine/uridine-preferring nucleoside hydrolase
Sporulation stage IV protein A C-terminal
Type II secretion system protein GspG C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
TRAP C4-dicarboxylate transport system permease DctM subunit
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Heat-inducible transcription repressor HrcA C-terminal
ABC transporter substrate-binding protein PnrA-like
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Probable transposase IS891/IS1136/IS1341
RsbT co-antagonist protein RsbRD N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Involved in allosteric activation by GTP
Acetylserotonin O-methyltransferase dimerisation
Prokaryotic-type class I peptide chain release factors
Schiff-base intermediate with D-ribose 5-phosphate
Stage III sporulation protein AA AAA+ ATPase
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Formylmethanofuran dehydrogenase subunit E
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Flagellar hook-length control protein-like C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
tRNA (guanine-N(1)-)-methyltransferase C-terminal
Sporulation transcription regulator WhiA N-terminal
Phage terminase large subunit C-terminal
Phage terminase large subunit N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Large ribosomal subunit protein uL6 alpha-beta
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Cytochrome oxidase subunit II copper A binding
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Polysaccharide biosynthesis protein C-terminal
Cation-transporting P-type ATPase N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Putative oxidoreductase/dehydrogenase Rossmann-like
Helix-hairpin-helix DNA-binding motif class 1
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
serine-type D-Ala-D-Ala carboxypeptidase
Survival protein SurE-like phosphatase/nucleotidase
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Large ribosomal subunit protein uL2 C-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Mannose-6-phosphate isomerase type II C-terminal
D-galactarate/Altronate dehydratase C-terminal
Alanyl-transfer RNA synthetases family profile
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Methylene-tetrahydrofolate reductase C-terminal
Peptidoglycan recognition protein family
Phosphoribosylformylglycinamidine synthase linker
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Molybdopterin cofactor biosynthesis C (MoaC)
Phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease 3
ABC-type sugar transport system, periplasmic component
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Flagellar Assembly Protein A N-terminal region
CO dehydrogenase/acetyl-CoA synthase complex beta subunit C-terminal
Carbon monoxide dehydrogenase subunit alpha ,N-terminal
Ionotropic glutamate receptor C-terminal
Pyrimidine nucleoside phosphorylase C-terminal
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
YbaK/aminoacyl-tRNA synthetase-associated
SAM-dependent methyltransferase TRM5/TYW2-type
Anthranilate synthase component I N-terminal
Cytochrome b/b6 C-terminal region profile
Important for beta-aspartyl-AMP intermediate formation
Exonuclease VII large subunit C-terminal
Meso-diaminopimelate D-dehydrogenase C-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Plays an important role in substrate specificity
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Sugar fermentation stimulation protein C-terminal
Interaction with polymerase core subunit RpoC
Damage-control phosphatase ARMT1-like metal-binding
Important for substrate specificity; cannot use PPi as phosphoryl donor
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Bacterial bifunctional deaminase-reductase C-terminal
Essential for prephenate dehydratase activity
N6 adenine-specific DNA methyltransferase N-terminal
Aldehyde ferredoxin oxidoreductase N-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Siroheme decarboxylase AsnC-like ligand binding
NADH-rubredoxin oxidoreductase C-terminal
Pseudouridine synthase I TruA alpha/beta
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Transcriptional coactivator p15 (PC4) C-terminal
RNA 2-O ribose methyltransferase substrate binding
Putative amidase domain-containing protein
Sporulation initiation factor Spo0A C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
ABC-type glycine betaine transport system substrate-binding
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Insecticide toxin TcdB middle/C-terminal
Insecticide toxin TcdB middle/N-terminal
Bacterial Ig-like domain-containing protein
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Ferrous iron transport protein B C-terminal
Methylguanine DNA methyltransferase ribonuclease-like
Type II secretion system protein GspE N-terminal
Small ribosomal subunit protein uS4 N-terminal
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Signal recognition particle SRP54 helical bundle
Shikimate dehydrogenase substrate binding N-terminal
Schiff-base intermediate with acetaldehyde
ATP synthase F1 complex delta/epsilon subunit N-terminal