3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Membrane fusion protein biotin-lipoyl like
Exonuclease VII large subunit C-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Solute-binding protein family 3/N-terminal
Pyruvate/ketoisovalerate oxidoreductase catalytic
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Polysaccharide chain length determinant N-terminal
Involved in allosteric activation by GTP
RND efflux pump membrane fusion protein barrel-sandwich
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Dipicolinate synthase subunit A N-terminal
Pyridoxamine 5'-phosphate oxidase putative
RNA polymerase sigma factor 70 region 4 type 2
Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
BAAT/Acyl-CoA thioester hydrolase C-terminal
Polysaccharide biosynthesis protein C-terminal
Anthranilate synthase component I N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Diacylglycerol glucosyltransferase N-terminal
Glycosyl transferase family 28 C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
DNA mismatch repair proteins mutS family
Penicillin-binding protein transpeptidase
Membrane iron-sulfur containing protein FtrD-like
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Methylene-tetrahydrofolate reductase C-terminal
Transcription regulator AsnC/Lrp ligand binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Aromatic amino acid beta-eliminating lyase/threonine aldolase
HicB-like antitoxin of toxin-antitoxin system
Plays an important role in substrate specificity
Tricarboxylic transport membrane protein
Major facilitator superfamily (MFS) profile
NADH:flavin oxidoreductase/NADH oxidase N-terminal
5-glutamyl coenzyme A thioester intermediate
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Putative component of 'biosynthetic module'
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Signal recognition particle SRP54 helical bundle
Dinitrogenase iron-molybdenum cofactor biosynthesis
Ionotropic glutamate receptor C-terminal
F420-non-reducing hydrogenase iron-sulfur subunit D
CobB/CobQ-like glutamine amidotransferase
Increases nucleophilicity of active site Cys
Gly-cisPro motif, important for rejection of L-amino acids
NADH-rubredoxin oxidoreductase C-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Flagellar hook-length control protein-like C-terminal
DnaJ homologue subfamily C member 28 conserved
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
NADH:ubiquinone oxidoreductase 30kDa subunit
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
S-adenosyl-L-homocysteine hydrolase NAD binding
Tripartite tricarboxylate transporter family receptor
Flagellar motor switch protein FliN-like C-terminal
Aldehyde ferredoxin oxidoreductase N-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Tryptophan synthase beta chain-like PALP
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Heparan-alpha-glucosaminide N-acetyltransferase catalytic
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Polymerase/histidinol phosphatase N-terminal
Thiamin pyrophosphokinase thiamin-binding
RsbT co-antagonist protein RsbRD N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Transposase IS116/IS110/IS902 C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Aldehyde oxidase/xanthine dehydrogenase second molybdopterin binding
Important for interaction with partner proteins
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
DNA-directed DNA polymerase family A palm
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
CO dehydrogenase/acetyl-CoA synthase delta subunit TIM barrel
Sodium/calcium exchanger membrane region
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Urease accessory protein UreH-like transmembrane
Schiff-base intermediate with D-ribose 5-phosphate
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Large ribosomal subunit protein uL15/eL18
Alpha-D-phosphohexomutase alpha/beta/alpha
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
ABC transporter substrate-binding protein PnrA-like
Thiamine pyrophosphate enzyme TPP-binding
Formylmethanofuran dehydrogenase subunit E
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Sporulation stage II protein D amidase enhancer LytB N-terminal
Damage-control phosphatase ARMT1-like metal-binding
Interaction with polymerase core subunit RpoC
FAD-dependent oxidoreductase 2 FAD binding
Cell envelope-related transcriptional attenuator
Sporulation initiation factor Spo0A C-terminal
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Polysaccharide biosynthesis protein CapD-like
Release factor glutamine methyltransferase N-terminal
Essential for prephenate dehydratase activity
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Important for substrate specificity; cannot use PPi as phosphoryl donor
Lysidine-tRNA(Ile) synthetase C-terminal
TRAP C4-dicarboxylate transport system permease DctM subunit
ATP synthase F1 complex delta/epsilon subunit N-terminal
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Bacterial transcription activator effector binding
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Phosphatidic acid phosphatase type 2/haloperoxidase
tRNA pseudouridylate synthase B C-terminal
Important for beta-aspartyl-AMP intermediate formation
Cytochrome c-552/4 domain-containing protein
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Thiamine pyrophosphate enzyme N-terminal TPP-binding
RNA 2-O ribose methyltransferase substrate binding
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
6-hydroxymethylpterin diphosphokinase MptE-like
Cytochrome b561 bacterial/Ni-hydrogenase
D-galactarate/Altronate dehydratase C-terminal
Alanyl-transfer RNA synthetases family profile
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Siroheme decarboxylase AsnC-like ligand binding
NADH-ubiquinone oxidoreductase 51kDa subunit FMN-binding
tRNA (guanine-N(1)-)-methyltransferase C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
RDXXRA motif of the pArg binding pocket involved in allosteric regulation
Shikimate dehydrogenase substrate binding N-terminal
Carbohydrate-binding domain-containing protein
O-(phosphoribosyl dephospho-coenzyme A)serine
Putative regulatory protein FmdB Zinc ribbon
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Large ribosomal subunit protein uL2 C-terminal
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
UDP-glucose/GDP-mannose dehydrogenase dimerisation
Large ribosomal subunit protein uL6 alpha-beta
Methylaspartate ammonia-lyase C-terminal
Methylaspartate ammonia-lyase N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Phosphatidylinositol-specific phospholipase C X
Small ribosomal subunit protein uS4 N-terminal
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Acetylserotonin O-methyltransferase dimerisation
Sporulation stage IV protein A C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Survival protein SurE-like phosphatase/nucleotidase
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Homocysteine biosynthesis enzyme sulfur-incorporation
Reversibly protonated during proton transport
dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase
Glycine cleavage T-protein C-terminal barrel
Pyrimidine nucleoside phosphorylase C-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Cation-transporting P-type ATPase N-terminal
Chromosomal replication initiator DnaA C-terminal
Bacterial type II secretion system protein E
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Formiminotransferase C-terminal subdomain
Formiminotransferase N-terminal subdomain
Carbamoyl-phosphate synthase small subunit N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Cyclophilin-like domain-containing protein
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Translation elongation factor P/YeiP central
Helix-hairpin-helix DNA-binding motif class 1
O-(3'-phospho-DNA)-tyrosine intermediate
Glycosyl transferase family 3 N-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
Gamma-glutamylcyclotransferase AIG2-like
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
DNA replication/recombination mediator RecO N-terminal
P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein
Aminoacyl-tRNA synthetase class I anticodon-binding
Ferrous iron transport protein B C-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Global transcriptional regulator CodY C-terminal
Global transcriptional regulator CodY N-terminal
NIF system FeS cluster assembly NifU N-terminal
Phosphatidylglycerol lysyltransferase C-terminal
Cytochrome b/b6 N-terminal region profile
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Heat-inducible transcription repressor HrcA C-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
serine-type D-Ala-D-Ala carboxypeptidase
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Saccharopine dehydrogenase-like C-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Gram-positive cocci surface proteins LPxTG domain-containing protein
Alpha-glycerophosphate oxidase C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Involved in ionization of N3 of dUMP, leading to its activation
Pseudouridine synthase I TruA alpha/beta
Type III secretion system flagellar brake protein YcgR PilZN
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Anti-bacteriophage protein A/HamA C-terminal
Sporulation transcription regulator WhiA N-terminal
Sugar fermentation stimulation protein C-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
CO dehydrogenase/acetyl-CoA synthase complex beta subunit C-terminal
Carbon monoxide dehydrogenase subunit alpha ,N-terminal