Cobalamin-independent methionine synthase MetE C-terminal/archaeal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
DNA primase/polymerase bifunctional N-terminal
Nicotinamide phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Ribosomal RNA adenine methylase transferase N-terminal
Penicillin-binding protein transpeptidase
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Phosphocysteine intermediate; for EIIB activity
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Cell envelope-related transcriptional attenuator
Important for catalytic activity and assists the phosphoryl transfer reaction to Asp8 by balancing charge and orienting the reacting groups
Major facilitator superfamily (MFS) profile
Menaquinone biosynthesis protein MenD middle
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase
DNA-directed RNA polymerase RpoA/D/Rpb3-type
X-Prolyl dipeptidyl aminopeptidase PepX N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
ATP synthase F1 complex delta/epsilon subunit N-terminal
Phosphomannose isomerase type I catalytic
Membrane insertase YidC/Oxa/ALB C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Gram-positive cocci surface proteins LPxTG
Gram-positive pilin backbone subunit 2 Cna-B-like
Gram-positive pilin subunit D1 N-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Exonuclease VII large subunit C-terminal
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase N-terminal
N6 adenine-specific DNA methyltransferase N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Polysaccharide biosynthesis protein C-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Type VII secretion system protein EssD-like
ABC transporter substrate-binding protein PnrA-like
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Inosine/uridine-preferring nucleoside hydrolase
Resolvase/invertase-type recombinase catalytic
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Thymidylate synthase/dCMP hydroxymethylase
Glycosyltransferase subfamily 4-like N-terminal
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Phosphatidic acid phosphatase type 2/haloperoxidase
Plays an important role in substrate specificity
Gram-positive cocci surface proteins LPxTG domain-containing protein
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Terminase large subunit-like endonuclease
6-phosphogluconate dehydrogenase C-terminal
RNA 2-O ribose methyltransferase substrate binding
NIF system FeS cluster assembly NifU N-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Cation-transporting P-type ATPase N-terminal
Glucosamine/galactosamine-6-phosphate isomerase
Restriction system protein Mrr-like N-terminal
DNA-directed DNA polymerase family A palm
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Large ribosomal subunit protein uL2 C-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Phage terminase large subunit C-terminal
Phage terminase large subunit N-terminal
Ribosomal RNA small subunit methyltransferase E methyltransferase
Alpha-D-phosphohexomutase alpha/beta/alpha
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Single-stranded-DNA-specific exonuclease RecJ C-terminal
Phosphotransferase system enzyme I N-terminal
Reversibly protonated during proton transport
Alanyl-transfer RNA synthetases family profile
Translation elongation factor P/YeiP central
DNA mismatch repair proteins mutS family
Bacterial bifunctional deaminase-reductase C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Signal recognition particle SRP54 helical bundle
O-(5'-phospho-DNA)-tyrosine intermediate
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
CobB/CobQ-like glutamine amidotransferase
Peptide methionine sulphoxide reductase MsrA
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Phage conserved hypothetical protein C-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Large ribosomal subunit protein uL6 alpha-beta
DNA replication/recombination mediator RecO N-terminal
Release factor glutamine methyltransferase N-terminal
Glycosyl transferase family 3 N-terminal
Type I restriction modification DNA specificity
Prokaryotic-type class I peptide chain release factors
Small ribosomal subunit protein uS4 N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Polymerase/histidinol phosphatase N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Gfo/Idh/MocA-like oxidoreductase N-terminal
RNA binding; important for wobble base 34 recognition
Tryptophan synthase beta chain-like PALP
Anthranilate synthase component I N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Electron transfer via tryptophanyl radical
Peptidase M1 membrane alanine aminopeptidase
Involved in allosteric activation by GTP
Cobalamin-independent methionine synthase MetE N-terminal
Membrane fusion protein biotin-lipoyl like
RNA polymerase sigma factor 70 region 4 type 2
Helix-hairpin-helix DNA-binding motif class 1
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Peptidase C39-like domain-containing protein
Carbamoyl-phosphate synthase small subunit N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Type III restriction enzyme C-terminal endonuclease
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Chromosomal replication initiator DnaA C-terminal
Phosphoribosylformylglycinamidine synthase linker
Type III restriction/modification enzyme methylation subunit
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Thiamin pyrophosphokinase thiamin-binding
Large ribosomal subunit protein uL15/eL18
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Pseudouridine synthase I TruA alpha/beta
O-(phosphoribosyl dephospho-coenzyme A)serine
Shikimate dehydrogenase substrate binding N-terminal
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
Important for interaction with partner proteins