Ribose-phosphate pyrophosphokinase N-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Pyruvate dehydrogenase E1 component middle
Major facilitator superfamily (MFS) profile
Activator of Hsp90 ATPase homologue 1-like C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Cytochrome oxidase subunit II copper A binding
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Putative regulatory protein FmdB Zinc ribbon
Peptidase S9 prolyl oligopeptidase catalytic
ABC-type glycine betaine transport system substrate-binding
Moves into active site upon enzyme activation, plays a role in electron transfer
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
NIF system FeS cluster assembly NifU N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Important for interaction with partner proteins
Membrane fusion protein biotin-lipoyl like
RND efflux pump membrane fusion protein barrel-sandwich
Acyltransferase MbtK/IucB-like conserved
Type VI secretion lipoprotein VC_A0113 family
D-galactarate/Altronate dehydratase C-terminal
Bacterial type II secretion system protein E
Membrane insertase YidC/Oxa/ALB C-terminal
Polymerase/histidinol phosphatase N-terminal
NAD(P) transhydrogenase alpha subunit C-terminal
FAD-dependent oxidoreductase 2 FAD binding
N6 adenine-specific DNA methyltransferase N-terminal
RNA polymerase sigma factor 70 region 4 type 2
Transcriptional coactivator p15 (PC4) C-terminal
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Solute-binding protein family 3/N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Phosphatidic acid phosphatase type 2/haloperoxidase
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Penicillin-binding protein transpeptidase
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Aldehyde oxidase/xanthine dehydrogenase first molybdopterin binding
Aldehyde oxidase/xanthine dehydrogenase second molybdopterin binding
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Ionotropic glutamate receptor C-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Heme-copper oxidase subunit III family profile
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Antitoxin Xre/MbcA/ParS-like toxin-binding
DNA replication/recombination mediator RecO N-terminal
Prepilin type IV endopeptidase peptidase
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
PhoD-like phosphatase metallophosphatase
Glycosyltransferase subfamily 4-like N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
PHA accumulation regulator DNA-binding N-terminal
Exonuclease VII large subunit C-terminal
Required for zinc-mediated homotetramerization and catalytic activity
Hydroquinone 1,2-dioxygenase large subunit N-terminal
Pyruvate/ketoisovalerate oxidoreductase catalytic
Tryptophan synthase beta chain-like PALP
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Type II secretion system protein GspI C-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Mannose-6-phosphate isomerase type II C-terminal
Glycogen debranching enzyme bacterial and archaeal type N-terminal
Peptide methionine sulfoxide reductase MsrA
Peptide methionine sulphoxide reductase MsrA
ABC-type transport auxiliary lipoprotein component
ABC-type transport auxiliary lipoprotein component domain-containing protein
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Outer membrane protein beta-barrel domain-containing protein
Bacterial bifunctional deaminase-reductase C-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
RNA binding; important for wobble base 34 recognition
Chromosomal replication initiator DnaA C-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Type III secretion system flagellar brake protein YcgR PilZN
Periplasmic binding protein/LacI sugar binding
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
Release factor glutamine methyltransferase N-terminal
Inosine/uridine-preferring nucleoside hydrolase
Gp5/Type VI secretion system Vgr protein OB-fold
Pyruvate phosphate dikinase AMP/ATP-binding
Chromosomal replication initiator protein DnaA
Interaction with polymerase core subunit RpoC
Mandelate racemase/muconate lactonizing enzyme C-terminal
Proline utilization A proline dehydrogenase N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Aconitase A/isopropylmalate dehydratase small subunit swivel
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
C-type lysozyme inhibitor domain-containing protein
Glutamate synthase alpha subunit C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
6-phosphogluconate dehydrogenase C-terminal
Outer membrane protein assembly factor BamB
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Gamma-butyrobetaine hydroxylase-like N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
CNP1-like uncharacterized domain-containing protein
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Cytochrome c-type biogenesis protein CcmF C-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Glucose-methanol-choline oxidoreductase N-terminal
Large ribosomal subunit protein uL2 C-terminal
Aspartate/homoserine dehydrogenase NAD-binding
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Acetylserotonin O-methyltransferase dimerisation
Cysteine sulfenic acid (-SOH) intermediate
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Polysaccharide chain length determinant N-terminal
Virulence factor membrane-bound polymerase C-terminal
Methylamine/Aralkylamine dehydrogenase light chain C-terminal
Tryptophylquinone 6'-substrate hemiaminal intermediate
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
TRAP C4-dicarboxylate transport system permease DctM subunit
YbaK/aminoacyl-tRNA synthetase-associated
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Quercetin 2,3-dioxygenase C-terminal cupin
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
Sodium/calcium exchanger membrane region
Prokaryotic-type class I peptide chain release factors
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
O-(3'-phospho-DNA)-tyrosine intermediate
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Flagellar assembly protein FliH/Type III secretion system HrpE
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Alpha-D-phosphohexomutase alpha/beta/alpha
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Bacteriophage N4 adsorption protein A C-terminal
Bacteriophage N4 adsorption protein A C-terminal domain-containing protein
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Disulphide bond isomerase DsbC/G N-terminal
Ribonucleotide reductase large subunit C-terminal
Ribulose bisphosphate carboxylase small subunit
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
O-(phosphoribosyl dephospho-coenzyme A)serine
Survival protein SurE-like phosphatase/nucleotidase
Glycoside hydrolase family 31 N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
NADH-rubredoxin oxidoreductase C-terminal
Required for dimer formation and molybdate binding
Large exoproteins involved in heme utilization or adhesion
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
TonB-dependent receptor-like beta-barrel
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
N,N-dimethylformamidase beta subunit-like C-terminal
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
Alpha-glycerophosphate oxidase C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Could play a key role in the communication between the regulatory and the substrate sites
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
L-seryl-tRNA selenium transferase N-terminal
peptide-methionine (R)-S-oxide reductase
Ribosomal RNA adenine methylase transferase N-terminal
Outer-membrane lipoprotein carrier protein
Rap1a immunity protein domain-containing protein
Small ribosomal subunit protein uS4 N-terminal
Endoribonuclease L-PSP/chorismate mutase-like
Phosphogluconate dehydrogenase (decarboxylating) C-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Seems to be a necessary countercharge to the potassium cations
Glucosamine/galactosamine-6-phosphate isomerase
Trimeric autotransporter adhesin YadA-like C-terminal membrane anchor
Trimeric autotransporter adhesin YadA-like head
Trimeric autotransporter adhesin YadA-like stalk
Phenol hydroxylase C-terminal dimerisation
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Integral membrane protein YccS N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Choloylglycine hydrolase/NAAA C-terminal
Caspase family p20 domain-containing protein
RlpA-like protein double-psi beta-barrel
CobB/CobQ-like glutamine amidotransferase
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Periplasmic nitrate reductase, electron transfer subunit
Vanillate O-demethylase oxygenase-like C-terminal catalytic
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Plays an important role in substrate specificity
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Transposase IS204/IS1001/IS1096/IS1165 DDE
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
High potential iron-sulfur proteins family profile
Flagellar hook-length control protein-like C-terminal
DNA mismatch repair proteins mutS family
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Phosphocysteine intermediate; for EIIB activity
Helix-hairpin-helix DNA-binding motif class 1
Outer-membrane lipoprotein Wza C-terminal
Glycine cleavage T-protein C-terminal barrel
TtsA-like Glycoside hydrolase family 108
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Flagellar motor switch protein FliN-like C-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-91)
Anthranilate synthase component I N-terminal
N-end rule aminoacyl transferase C-terminal
DNA polymerase III subunit delta C-terminal
Poly-beta-hydroxybutyrate polymerase N-terminal
Cytochrome c-type biogenesis protein CcmE
Lysidine-tRNA(Ile) synthetase C-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Glycosyl transferase family 3 N-terminal
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Thymidylate synthase/dCMP hydroxymethylase
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Aminoacyl-tRNA synthetase class I anticodon-binding
Lysozyme inhibitor LprI N-terminal domain-containing protein
Putative type VI secretion system Rhs element associated Vgr
ABC transporter substrate-binding protein PnrA-like
Pseudouridine synthase I TruA alpha/beta
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Large ribosomal subunit protein uL15/eL18
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Gamma-glutamylcyclotransferase AIG2-like
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
O-(5'-phospho-DNA)-tyrosine intermediate
Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr C-terminal
Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr N-terminal
Tetrahydrodipicolinate-N-succinyltransferase chain A
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Alanyl-transfer RNA synthetases family profile
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
ATP synthase F1 complex delta/epsilon subunit N-terminal
Glycine-zipper-containing OmpA-like membrane
Essential for prephenate dehydratase activity
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Putative glycogen debranching enzyme N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Large ribosomal subunit protein uL6 alpha-beta
EfeO-type cupredoxin-like domain-containing protein
Translation elongation factor P/YeiP central