Gfo/Idh/MocA-like oxidoreductase N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family protein
Pyruvate dehydrogenase E1 component middle
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Survival protein SurE-like phosphatase/nucleotidase
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Major facilitator superfamily (MFS) profile
Polymerase/histidinol phosphatase N-terminal
Glycosyltransferase subfamily 4-like N-terminal
Signal peptide-domain containing protein
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Small ribosomal subunit protein uS4 N-terminal
RND efflux pump membrane fusion protein barrel-sandwich
3-keto-disaccharide hydrolase domain-containing protein
Carboxypeptidase regulatory-like domain-containing protein
Alpha-D-phosphohexomutase alpha/beta/alpha
Formamidopyrimidine-DNA glycosylase catalytic
N-sulphoglucosamine sulphohydrolase C-terminal
Gfo/Idh/MocA-like oxidoreductase bacterial type C-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Transposase IS116/IS110/IS902 C-terminal
Penicillin-binding protein transpeptidase
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Flagellar motor switch protein FliN-like C-terminal
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Bacterial type II secretion system protein E
RNA polymerase sigma factor 70 region 4 type 2
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Nitrite/Sulfite reductase ferredoxin-like
Choloylglycine hydrolase/NAAA C-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Ribose-phosphate pyrophosphokinase N-terminal
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
DNA mismatch repair proteins mutS family
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Pyruvate phosphate dikinase AMP/ATP-binding
SUF system FeS cluster assembly SufBD N-terminal
Important for beta-aspartyl-AMP intermediate formation
Peptidase MA-like domain-containing protein
16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal
LamG-like jellyroll fold domain-containing protein
S-adenosylmethionine-dependent methyltransferase
Inosine/uridine-preferring nucleoside hydrolase
Cytochrome C biogenesis protein transmembrane
Thiol:disulfide interchange protein DsbD N-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Tetratricopeptide TPR_1 repeat-containing protein
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Translation elongation factor P/YeiP central
Prepilin type IV endopeptidase peptidase
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
DNA replication/recombination mediator RecO N-terminal
Resolvase/invertase-type recombinase catalytic
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
RNA 2-O ribose methyltransferase substrate binding
Large ribosomal subunit protein uL6 alpha-beta
Na+/H+ antiporter MnhB subunit-related protein
Solute-binding protein family 3/N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Release factor glutamine methyltransferase N-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Pseudouridine synthase I TruA alpha/beta
PBS lyase HEAT domain protein repeat-containing protein
Glutamate synthase alpha subunit C-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Mechanosensitive ion channel inner membrane
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Calcineurin-like phosphoesterase domain-containing protein
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Type I restriction modification DNA specificity
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Trypsin-like peptidase domain-containing protein
Phosphatidate phosphatase APP1 catalytic
Carbamoyl-phosphate synthase small subunit N-terminal
Flagellar basal-body/hook protein C-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Tryptophan synthase beta chain-like PALP
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Phosphoribosylformylglycinamidine synthase linker
NADH:flavin oxidoreductase/NADH oxidase N-terminal
S-adenosyl-L-homocysteine hydrolase NAD binding
Peptidoglycan recognition protein family
Nucleic acid binding OB-fold tRNA/helicase-type
Activator of Hsp90 ATPase homologue 1-like C-terminal
Helix-hairpin-helix DNA-binding motif class 1
Anti-bacteriophage protein A/HamA C-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein
Chromosomal replication initiator DnaA C-terminal
DNA-directed DNA polymerase family A palm
N6 adenine-specific DNA methyltransferase N-terminal
PhoD-like phosphatase metallophosphatase
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Peptidase M1 membrane alanine aminopeptidase
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Heme-copper oxidase subunit III family profile
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Inverse autotransporter beta-domain domain-containing protein
Flagellar basal body rod protein N-terminal
Large ribosomal subunit protein uL2 C-terminal
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Positions MEP for the nucleophilic attack
Right handed beta helix domain-containing protein
Endoribonuclease L-PSP/chorismate mutase-like
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Gly-cisPro motif, important for rejection of L-amino acids
Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
Trigger factor ribosome-binding bacterial
Glyoxalase/fosfomycin resistance/dioxygenase
Aconitase A/isopropylmalate dehydratase small subunit swivel
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Periplasmic copper-binding protein NosD beta helix
Alanyl-transfer RNA synthetases family profile
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Methylene-tetrahydromethanopterin dehydrogenase N-terminal
Terminase large subunit-like endonuclease
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Large ribosomal subunit protein uL15/eL18
Anthranilate synthase component I N-terminal
Gamma-glutamylcyclotransferase AIG2-like
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Protein-L-isoaspartate O-methyltransferase
D-glutamate N-acetyltransferase-like C-terminal
D-glutamate N-acetyltransferase-like N-terminal
Type II secretion system protein GspE N-terminal
Proteinase inhibitor I42 chagasin domain-containing protein
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Plays an important role in substrate specificity
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Peptidase C45 acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
Polysaccharide pyruvyl transferase domain-containing protein
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Alpha-amylase/4-alpha-glucanotransferase C-terminal
Alpha-amylase/4-alpha-glucanotransferase central
Glycoside hydrolase family 57 N-terminal
ABC-type uncharacterised transport system
Polysaccharide biosynthesis protein C-terminal
Phosphomannose isomerase type I catalytic
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Bacterial transcription activator effector binding
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Glycosyltransferase 2-like prokaryotic type
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Pyrrolo-quinoline quinone repeat-containing protein
Involved in ionization of N3 of dUMP, leading to its activation
RNA binding; important for wobble base 34 recognition
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Phosphotransferase system enzyme I N-terminal
Exonuclease VII large subunit C-terminal
Proton acceptor; for glutaminase activity
UDP N-acetylglucosamine O-acyltransferase C-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Mu-protocadherin-putative cell-suface protein
ATP synthase F1 complex delta/epsilon subunit N-terminal
AB hydrolase-1 domain-containing protein
Glucosamine/galactosamine-6-phosphate isomerase
Bacterial bifunctional deaminase-reductase C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Putative regulatory protein FmdB Zinc ribbon
Translation elongation factor EFTs/EF1B dimerisation
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Urease accessory protein UreH-like transmembrane
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
ATPsynthase alpha/beta subunit N-terminal extension
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Gamma-butyrobetaine hydroxylase-like N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Essential for prephenate dehydratase activity
Flagellar hook-length control protein-like C-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
Iron dependent repressor metal binding and dimerisation
Histidine-specific methyltransferase SAM-dependent
3-beta hydroxysteroid dehydrogenase/isomerase
DNA primase/polymerase bifunctional N-terminal
Phosphatidylglycerol lysyltransferase C-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Gp5/Type VI secretion system Vgr protein OB-fold
Lipocalin-like domain-containing protein
Interaction with polymerase core subunit RpoC
Ribosomal RNA adenine methylase transferase N-terminal
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
6-phosphogluconate dehydrogenase C-terminal
Glycine cleavage T-protein C-terminal barrel
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Sodium/calcium exchanger membrane region
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)