S-adenosyl-L-homocysteine hydrolase NAD binding
Probable transposase IS891/IS1136/IS1341
NADH:flavin oxidoreductase/NADH oxidase N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Aminoacyl-transfer RNA synthetases class-II family profile
Glycosyltransferase subfamily 4-like N-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Mannose-6-phosphate isomerase type II C-terminal
Ionotropic glutamate receptor C-terminal
Solute-binding protein family 3/N-terminal
SUF system FeS cluster assembly SufBD N-terminal
Septum formation inhibitor MinC C-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Polymerase/histidinol phosphatase N-terminal
Survival protein SurE-like phosphatase/nucleotidase
ABC-type uncharacterised transport system
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Ribulose bisphosphate carboxylase small subunit
Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding
Magnesium chelatase subunit H N-terminal
RNA polymerase sigma factor 70 region 4 type 2
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Glycoside hydrolase family 57 N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Ribosome maturation factor RimP N-terminal
Photosystem II cytochrome b559 N-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Type I restriction modification DNA specificity
TonB-dependent receptor-like beta-barrel
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Phosphoadenosine phosphosulphate reductase
RNA 2-O ribose methyltransferase substrate binding
Menaquinone biosynthesis protein MenD middle
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Ferredoxin thioredoxin reductase alpha chain
Heat-inducible transcription repressor HrcA C-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Ferrous iron transport protein B C-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
DNA-directed DNA polymerase family A palm
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Involved in allosteric activation by GTP
Magnesium-protoporphyrin IX methyltransferase C-terminal
Schiff-base intermediate with acetaldehyde
Peptide methionine sulfoxide reductase MsrA
Peptide methionine sulphoxide reductase MsrA
Shikimate dehydrogenase substrate binding N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Membrane fusion protein biotin-lipoyl like
Cytochrome b/b6 C-terminal region profile
HicB-like antitoxin of toxin-antitoxin system
Cytochrome C biogenesis protein transmembrane
Major facilitator superfamily (MFS) profile
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Homocysteine biosynthesis enzyme sulfur-incorporation
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Could be important to modulate the pK values of the two catalytic cysteine residues
Bacterial type II secretion system protein E
Cell envelope-related transcriptional attenuator
Nicotinamide phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
NADH:ubiquinone oxidoreductase 30kDa subunit
Cysteine sulfenic acid (-SOH) intermediate
Sugar fermentation stimulation protein C-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Filamentous hemagglutinin family outer membrane protein
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
S-adenosyl-l-methionine hydroxide adenosyltransferase C-terminal
S-adenosyl-l-methionine hydroxide adenosyltransferase N-terminal
NAD(P)H-quinone oxidoreductase subunit 2 N-terminal
PEP-CTERM sorting domain-containing protein
CRISPR system ring nuclease SSO1393-like
Tryptophan synthase beta chain-like PALP
Alpha-glycerophosphate oxidase C-terminal
Cyanobacterial aminoacyl-tRNA synthetase CAAD
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Large ribosomal subunit protein uL2 C-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
CobB/CobQ-like glutamine amidotransferase
Sporulation stage II protein D amidase enhancer LytB N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Photosystem II manganese-stabilizing polypeptide
Gamma-glutamylcyclotransferase AIG2-like
Coenzyme F420 hydrogenase/dehydrogenase beta subunit C-terminal
Coenzyme F420 hydrogenase/dehydrogenase beta subunit N-terminal
Lipocalin-like domain-containing protein
Cytochrome b561 bacterial/Ni-hydrogenase
Plays an important role in substrate specificity
NIF system FeS cluster assembly NifU C-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Peptidase S9 prolyl oligopeptidase catalytic
NADH:ubiquinone/plastoquinone oxidoreductase chloroplast chain 5 C-terminal
Essential for prephenate dehydratase activity
Increases nucleophilicity of active site Cys
Phosphoribosylformylglycinamidine synthase linker
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Alanyl-transfer RNA synthetases family profile
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Cob(I)alamin adenosyltransferase N-terminal
Quercetin 2,3-dioxygenase C-terminal cupin
Beta-carotene isomerase D27-like C-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Anthranilate synthase component I N-terminal
DNA mismatch repair proteins mutS family
Glycosyl transferase family 3 N-terminal
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Polypeptide-transport-associated ShlB-type
Type II restriction enzyme and methyltransferase RM.Eco57I-like
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Ribose-phosphate pyrophosphokinase N-terminal
Type ISP restriction-modification enzyme LLaBIII C-terminal specificity
CRISPR-associated protein Cas6 C-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Lantibiotic biosynthesis protein dehydration
Histidine-specific methyltransferase SAM-dependent
Glucosamine/galactosamine-6-phosphate isomerase
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Sodium/calcium exchanger membrane region
Schiff-base intermediate with substrate; via pyruvic acid
Helix-hairpin-helix DNA-binding motif class 1
Ribosomal RNA adenine methylase transferase N-terminal
Translation elongation factor P/YeiP central
RND efflux pump membrane fusion protein barrel-sandwich
DNA replication/recombination mediator RecO N-terminal
NADH:ubiquinone oxidoreductase chain 4 N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
RNA-binding protein Tab2-like N-terminal
RNA-binding protein Tab2/Atab2 C-terminal
Interacts with tRNA; defines subfamily-specific binding signature
CRISPR-associated protein Cmr2 N-terminal
Prokaryotic-type class I peptide chain release factors
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Proton acceptor; for glutaminase activity
Nitrite/Sulfite reductase ferredoxin-like
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Nuclear transport factor 2 family protein
Small ribosomal subunit protein uS4 N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Light-independent protochlorophyllide reductase subunit B-like C-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Large ribosomal subunit protein uL6 alpha-beta
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
Electron transfer via tryptophanyl radical
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
RNA binding; important for wobble base 34 recognition
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Penicillin-binding protein transpeptidase
Arginine decarboxylase C-terminal helical
Interaction with polymerase core subunit RpoC
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
TRAP C4-dicarboxylate transport system permease DctM subunit
Glycosyl-hydrolase family 116 N-terminal
Glycosyl-hydrolase family 116 catalytic region
Cytochrome b/b6 N-terminal region profile
Glycine cleavage T-protein C-terminal barrel
Signal transduction histidine kinase osmosensitive K+ channel sensor N-terminal
Photosystem II cytochrome b559 alpha subunit lumenal region
Increases the nucleophilicity of the active site Cys
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-94)
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Bacterial Glycosyl hydrolase family 3 C-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
Spore coat protein U domain-containing protein
RNA methyltransferase SpoU/TrmH type C-terminal
Positions MEP for the nucleophilic attack
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Large ribosomal subunit protein uL15/eL18
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Na+/H+ antiporter MnhB subunit-related protein
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
RlpA-like protein double-psi beta-barrel
ATP synthase F1 complex delta/epsilon subunit N-terminal
Photosystem II reaction center protein K
Bacterial bifunctional deaminase-reductase C-terminal
Pseudouridine synthase I TruA alpha/beta
Heme-copper oxidase subunit III family profile
Reversibly protonated during proton transport
Photosystem I reaction center subunit III
Arsenosugar biosynthesis radical SAM protein ArsS-like C-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
6-phosphogluconate dehydrogenase C-terminal
Rubisco accumulation factor 1 C-terminal
Rubisco accumulation factor 1 alpha helical
Rubisco accumulation factor 1 helix turn helix
Choloylglycine hydrolase/NAAA C-terminal
Inward rectifier potassium channel C-terminal
Peptidase M1 membrane alanine aminopeptidase
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Urease accessory protein UreE C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Molybdopterin cofactor biosynthesis C (MoaC)
Plastid lipid-associated protein/fibrillin conserved
Membrane insertase YidC/Oxa/ALB C-terminal
Alpha-L-rhamnosidase six-hairpin glycosidase
Putative glycogen debranching enzyme N-terminal
Polysaccharide chain length determinant N-terminal
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
DNA primase/polymerase bifunctional N-terminal
May play a role in metal incorporation in vivo
May play a role in transmitting local conformational changes
Could play a key role in the communication between the regulatory and the substrate sites