RND efflux pump membrane fusion protein barrel-sandwich
Major facilitator superfamily (MFS) profile
Aminoacyl-transfer RNA synthetases class-II family profile
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Dinitrogenase iron-molybdenum cofactor biosynthesis
ABC-type transport auxiliary lipoprotein component
Activator of Hsp90 ATPase homologue 1-like C-terminal
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Solute-binding protein family 3/N-terminal
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Water stress and hypersensitive response
RNA polymerase sigma factor 70 region 4 type 2
Gp5/Type VI secretion system Vgr protein OB-fold
Putative type VI secretion system Rhs element associated Vgr
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
TonB-dependent receptor-like beta-barrel
Gamma-butyrobetaine hydroxylase-like N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Heme-copper oxidase subunit III family profile
DNA-directed DNA polymerase family B exonuclease
DNA-directed DNA polymerase family B multifunctional
DNA-3-methyladenine glycosylase AlkA N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Polypeptide-transport-associated ShlB-type
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Mannose-6-phosphate isomerase type II C-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Ionotropic glutamate receptor C-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
TtsA-like Glycoside hydrolase family 108
Membrane fusion protein biotin-lipoyl like
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Periplasmic binding protein/LacI sugar binding
The binding site for the sugar molecule has not yet been established, but C-87 may be involved
Transposase IS116/IS110/IS902 C-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Plays an important role in substrate specificity
Tryptophan synthase beta chain-like PALP
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Outer membrane protein assembly factor BamB
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
DNA topoisomerase I catalytic core eukaryotic-type
Glycosyltransferase subfamily 4-like N-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Glucose-methanol-choline oxidoreductase C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Poly-beta-hydroxybutyrate polymerase N-terminal
Inosine/uridine-preferring nucleoside hydrolase
Polymerase/histidinol phosphatase N-terminal
Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr C-terminal
Formylmethanofuran: tetrahydromethanopterin formyltransferase Ftr N-terminal
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
Signal recognition particle SRP54 helical bundle
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
RNA binding; important for wobble base 34 recognition
Bacterial type II secretion system protein E
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Cysteine sulfenic acid (-SOH) intermediate
TRAP C4-dicarboxylate transport system permease DctM subunit
Endoribonuclease L-PSP/chorismate mutase-like
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
6-phosphogluconate dehydrogenase C-terminal
Antitoxin Xre/MbcA/ParS-like toxin-binding
ABC transporter substrate-binding protein PnrA-like
Thiol:disulfide interchange protein DsbD
Gamma-glutamylcyclotransferase AIG2-like
Pyruvate dehydrogenase E1 component middle
Polysaccharide biosynthesis protein CapD-like
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Prepilin type IV endopeptidase peptidase
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Malonate/sodium symporter MadM subunit N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Chromosomal replication initiator protein DnaA
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Histidine-specific methyltransferase SAM-dependent
Interaction with polymerase core subunit RpoC
2-oxoacid dehydrogenase acyltransferase catalytic
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Photosynthesis system II assembly factor Ycf48/Hcf136-like
DNA-directed DNA polymerase family A palm
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Penicillin-binding protein transpeptidase
Glycoside hydrolase family 42 N-terminal
Plays an important role in discriminating NADH against NADPH
Helix-hairpin-helix DNA-binding motif class 1
Quercetin 2,3-dioxygenase C-terminal cupin
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Ribonucleotide reductase large subunit C-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Extradiol ring-cleavage dioxygenase LigAB LigA subunit
Mandelate racemase/muconate lactonizing enzyme C-terminal
Glycine cleavage T-protein C-terminal barrel
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Alpha-glycerophosphate oxidase C-terminal
Interacts with tRNA; defines subfamily-specific binding signature
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Molybdopterin cofactor biosynthesis C (MoaC)
Chromosomal replication initiator DnaA C-terminal
Phosphogluconate dehydrogenase (decarboxylating) C-terminal
Putative oxidoreductase/dehydrogenase Rossmann-like
Outer membrane protein assembly factor BamA
UDP N-acetylglucosamine O-acyltransferase C-terminal
Rap1a immunity protein domain-containing protein
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Involved in tetramerization or stability of the tetramer
S-adenosyl-L-homocysteine hydrolase NAD binding
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Glycoside hydrolase family 5 domain-containing protein
Formamidopyrimidine-DNA glycosylase catalytic
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Schiff-base intermediate with substrate; via pyruvic acid
Glycine-zipper-containing OmpA-like membrane
Pyridoxamine 5'-phosphate oxidase putative
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Trimeric autotransporter adhesin YadA-like C-terminal membrane anchor
Trimeric autotransporter adhesin YadA-like head
Trimeric autotransporter adhesin YadA-like stalk
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-91)
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
YbaK/aminoacyl-tRNA synthetase-associated
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Alanyl-transfer RNA synthetases family profile
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Proline utilization A proline dehydrogenase N-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Polysaccharide chain length determinant N-terminal
Lytic transglycosylase superhelical linker
ParB-related ThiF-related cassette protein E
Putative glycogen debranching enzyme N-terminal
Putative regulatory protein FmdB Zinc ribbon
Type VI secretion system IcmF C-terminal
Prokaryotic-type class I peptide chain release factors
NADH:ubiquinone oxidoreductase 30kDa subunit
Could play a key role in the communication between the regulatory and the substrate sites
ATP-grasp fold succinyl-CoA synthetase-type
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
NADH:flavin oxidoreductase/NADH oxidase N-terminal
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Flagellar motor switch protein FliN-like C-terminal
Superoxide dismutase copper/zinc binding
Cytochrome b561 bacterial/Ni-hydrogenase
NAD(P) transhydrogenase alpha subunit C-terminal
SMP-30/Gluconolactonase/LRE-like region domain-containing protein
Glycoside hydrolase family 31 N-terminal
Lysozyme inhibitor LprI N-terminal domain-containing protein
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
DNA replication/recombination mediator RecO N-terminal
Bacterial bifunctional deaminase-reductase C-terminal
Large ribosomal subunit protein uL2 C-terminal
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Methylene-tetrahydromethanopterin dehydrogenase N-terminal
DNA mismatch repair proteins mutS family
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Virulence factor membrane-bound polymerase C-terminal
DNA-binding and helicase activity, interacts with RecC
Nuclease activity, interacts with RecD and RecA
Flagellar hook-length control protein-like C-terminal
Required for zinc-mediated homotetramerization and catalytic activity
Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:ubiquinone/plastoquinone oxidoreductase chloroplast chain 5 C-terminal
High potential iron-sulfur proteins family profile
Pyridine nucleotide-disulphide oxidoreductase dimerisation
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
O-(3'-phospho-DNA)-tyrosine intermediate
Small ribosomal subunit protein uS4 N-terminal
Phosphocysteine intermediate; for EIIB activity
PHA accumulation regulator DNA-binding N-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Guanylate kinase/L-type calcium channel beta subunit
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Required for dimer formation and molybdate binding
Glutamate synthase alpha subunit C-terminal
Pectate lyase superfamily protein domain-containing protein
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
CobB/CobQ-like glutamine amidotransferase
Glycosyl transferase family 3 N-terminal
Transposase IS204/IS1001/IS1096/IS1165 DDE
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Ribose-phosphate pyrophosphokinase N-terminal
Type III secretion system flagellar brake protein YcgR PilZN
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Cytochrome C biogenesis protein transmembrane
Survival protein SurE-like phosphatase/nucleotidase
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal
Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal
Important for interaction with partner proteins
Thymidylate synthase/dCMP hydroxymethylase
Ribosomal RNA adenine methylase transferase N-terminal
Anthranilate synthase component I N-terminal
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Glycine zipper domain-containing protein
Type II secretion system protein GspG C-terminal
NIF system FeS cluster assembly NifU N-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Glycine zipper 2TM domain-containing protein
Surface antigen domain-containing protein
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
DNA polymerase III subunit delta C-terminal
Phosphoadenosine phosphosulphate reductase
Phenol hydroxylase C-terminal dimerisation
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Glucosamine/galactosamine-6-phosphate isomerase
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Bacteriophage T7 Gp4 DNA primase/helicase N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Pyruvate phosphate dikinase AMP/ATP-binding
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Phosphoribosylformylglycinamidine synthase N-terminal
Phosphoribosylformylglycinamidine synthase linker
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
N6 adenine-specific DNA methyltransferase N-terminal
Lipopolysaccharide export system protein LptA
Organic solvent tolerance-like N-terminal
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Membrane insertase YidC/Oxa/ALB C-terminal
Toxin co-regulated pilus biosynthesis protein Q C-terminal
Ribulose bisphosphate carboxylase small subunit
Isocitrate dehydrogenase kinase/phosphatase (AceK) kinase
Isocitrate dehydrogenase kinase/phosphatase (AceK) regulatory
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
N-end rule aminoacyl transferase C-terminal
Disulphide bond isomerase DsbC/G N-terminal
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
ABC-type glycine betaine transport system substrate-binding
Heat-inducible transcription repressor HrcA C-terminal
Winged helix-turn-helix transcription repressor HrcA DNA-binding
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Exonuclease VII large subunit C-terminal
Lysidine-tRNA(Ile) synthetase C-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
Type II secretion system protein GspI C-terminal
Integral membrane protein YccS N-terminal
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
O-(5'-phospho-DNA)-tyrosine intermediate
Ysc84 actin-binding domain-containing protein
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Peptide methionine sulphoxide reductase MsrA
Reversibly protonated during proton transport
Large ribosomal subunit protein uL6 alpha-beta
Peptidase S9 prolyl oligopeptidase catalytic
Phosphatidylglycerol lysyltransferase C-terminal
Nicotinamide phosphoribosyltransferase N-terminal
Essential for prephenate dehydratase activity
Aminoacyl-tRNA synthetase class II (G/ P/ S/T)
Proton acceptor; for glutaminase activity
Peptide methionine sulfoxide reductase MsrA
Phosphotransferase system enzyme I N-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Saccharopine dehydrogenase-like C-terminal
Glycogen debranching enzyme bacterial and archaeal type N-terminal
Acyl-CoA dehydrogenase C-terminal bacterial-type
Alpha-D-phosphohexomutase alpha/beta/alpha
Nucleophile; cysteine thiosulfonate intermediate
O-(phosphoribosyl dephospho-coenzyme A)serine
YMGG-like Gly-zipper domain-containing protein
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Pseudouridine synthase I TruA alpha/beta
Tetrahydrodipicolinate-N-succinyltransferase chain A
HicB-like antitoxin of toxin-antitoxin system
Could be important to modulate the pK values of the two catalytic cysteine residues
Large ribosomal subunit protein uL15/eL18
DnaJ homologue subfamily C member 28 conserved
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Nitrogenase molybdenum-iron protein beta chain N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Cation-transporting P-type ATPase N-terminal
Inward rectifier potassium channel C-terminal
Positions MEP for the nucleophilic attack
Na+/H+ antiporter MnhB subunit-related protein
ssDNA thymidine ADP-ribosyltransferase DarT
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Carbamoyl-phosphate synthase small subunit N-terminal
RNA 2-O ribose methyltransferase substrate binding
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Sodium/calcium exchanger membrane region
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Translation elongation factor P/YeiP central
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Photosynthesis system II assembly factor Ycf48/Hcf136-like domain-containing protein
Release factor glutamine methyltransferase N-terminal
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Glyoxalase/fosfomycin resistance/dioxygenase
Polysaccharide biosynthesis protein C-terminal
Adaptive response protein AidB N-terminal