RNA 2-O ribose methyltransferase substrate binding
Major facilitator superfamily (MFS) profile
Aminoacyl-transfer RNA synthetases class-II family profile
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
3-hydroxybutyryl-CoA dehydrogenase reduced Rossmann-fold
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Exonuclease VII large subunit C-terminal
Important for substrate specificity; cannot use PPi as phosphoryl donor
Quercetin 2,3-dioxygenase C-terminal cupin
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase middle
LPXTG cell wall anchor domain-containing protein
tRNA pseudouridine synthase II TruB subfamily 2 C-terminal
tRNA pseudouridylate synthase B C-terminal
Glucose-methanol-choline oxidoreductase N-terminal
Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase C-terminal
Cell envelope-related transcriptional attenuator
N-acetylneuraminic acid synthase N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Pyridoxamine 5'-phosphate oxidase putative
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
DNA-directed DNA polymerase family A palm
Histidine-specific methyltransferase SAM-dependent
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Large ribosomal subunit protein uL15/eL18
Cytochrome bc1 complex cytochrome c subunit
DNA primase/polymerase bifunctional N-terminal
Aconitase A/isopropylmalate dehydratase small subunit swivel
Thiamine pyrophosphate enzyme TPP-binding
Glycosyltransferase subfamily 4-like N-terminal
Reversibly protonated during proton transport
S-adenosyl-L-homocysteine hydrolase NAD binding
Bacterial bifunctional deaminase-reductase C-terminal
RNA polymerase sigma factor 70 region 4 type 2
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Mandelate racemase/muconate lactonizing enzyme C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Helix-hairpin-helix DNA-binding motif class 1
Gfo/Idh/MocA-like oxidoreductase C-terminal
Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-? in acceptor proteins)
Cation-transporting P-type ATPase N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Gly-cisPro motif, important for rejection of L-amino acids
UDP-glucose/GDP-mannose dehydrogenase C-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Bacterial type II secretion system protein E
Large ribosomal subunit protein uL2 C-terminal
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Solute-binding protein family 3/N-terminal
Peptidase M1 membrane alanine aminopeptidase
Positions MEP for the nucleophilic attack
Tryptophan synthase beta chain-like PALP
Shikimate dehydrogenase substrate binding N-terminal
Formamidopyrimidine-DNA glycosylase catalytic
Mycothiol-dependent maleylpyruvate isomerase metal-binding
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Ionotropic glutamate receptor C-terminal
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
ABC transporter substrate-binding protein PnrA-like
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Damage-control phosphatase ARMT1-like metal-binding
Polymerase/histidinol phosphatase N-terminal
Integral membrane protein YccS N-terminal
PhoD-like phosphatase metallophosphatase
Acyl-CoA dehydrogenase/oxidase N-terminal
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
CobB/CobQ-like glutamine amidotransferase
Alkaline shock response membrane anchor protein AmaP
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Peptidase S33 tripeptidyl aminopeptidase-like C-terminal
SUF system FeS cluster assembly SufBD N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Schiff-base intermediate with substrate; via pyruvic acid
Peptidoglycan recognition protein family
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Nuclear transport factor 2 family protein
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Penicillin-binding protein transpeptidase
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Prokaryotic-type class I peptide chain release factors
Schiff-base intermediate with D-ribose 5-phosphate
Endoribonuclease L-PSP/chorismate mutase-like
Myo-inositol-1-phosphate synthase GAPDH-like
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Pseudouridine synthase I TruA alpha/beta
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Could play a key role in the communication between the regulatory and the substrate sites
Alpha-glycerophosphate oxidase C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Extradiol ring-cleavage dioxygenase class III enzyme subunit B
Sporulation transcription regulator WhiA N-terminal
Beta-hexosaminidase bacterial type N-terminal
Ribosomal RNA adenine methylase transferase N-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
NADH:ubiquinone oxidoreductase 30kDa subunit
6-phosphogluconate dehydrogenase C-terminal
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
ABC-type glycine betaine transport system substrate-binding
Glucosamine/galactosamine-6-phosphate isomerase
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
tRNA(Ile)-lysidine synthase substrate-binding
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Molybdopterin cofactor biosynthesis C (MoaC)
Adaptive response protein AidB N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Sodium/calcium exchanger membrane region
Phosphomannose isomerase type I catalytic
Prepilin type IV endopeptidase peptidase
Glycosyl hydrolase-like 10 domain-containing protein
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding
Plays an important role in substrate specificity
Lysyl-tRNA synthetase N-terminal transmembrane region
Phosphatidylglycerol lysyltransferase C-terminal
Putative Flp pilus-assembly TadG-like N-terminal
ATP synthase F1 complex delta/epsilon subunit N-terminal
Right handed beta helix domain-containing protein
Probable subtilase-type protease inhibitor
Putative regulatory protein FmdB Zinc ribbon
Large ribosomal subunit protein uL6 alpha-beta
Cell wall-active antibiotics response LiaF-like C-terminal
Pyruvate dehydrogenase E1 component middle
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Methylguanine DNA methyltransferase ribonuclease-like
Thiopeptide-type bacteriocin biosynthesis
Methionyl-tRNA synthetase anticodon-binding
Release factor glutamine methyltransferase N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Cobalamin-independent methionine synthase MetE N-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Glycoside hydrolase family 42 N-terminal
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Ribose-phosphate pyrophosphokinase N-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Cytochrome b561 bacterial/Ni-hydrogenase
Pyrroline-5-carboxylate reductase catalytic N-terminal
Transposase IS116/IS110/IS902 C-terminal
Proton donor; for beta-elimination activity
Proton donor; for delta-elimination activity
Putative oxidoreductase/dehydrogenase Rossmann-like
Involved in allosteric activation by GTP
Anthranilate synthase component I N-terminal
Translation elongation factor P/YeiP central
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Phosphocysteine intermediate; for EIIB activity
Small ribosomal subunit protein uS4 N-terminal
Alpha-L-rhamnosidase six-hairpin glycosidase
Bacterial alpha-L-rhamnosidase N-terminal
Ricin B lectin domain-containing protein
Gram-positive cocci surface proteins LPxTG
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Pyruvate/ketoisovalerate oxidoreductase catalytic
Nitrite/Sulfite reductase ferredoxin-like
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Heat-inducible transcription repressor HrcA C-terminal
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
NIF system FeS cluster assembly NifU N-terminal
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
MmyB-like transcription regulator ligand binding
Cytochrome b/b6 N-terminal region profile
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Removed in mature form; by autocatalysis
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
O-(5'-phospho-DNA)-tyrosine intermediate
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Elongation factor G-binding protein C-terminal treble-clef zinc-finger
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Cytochrome bc1 complex Rieske iron-sulfur subunit
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Transcription regulator AsnC/Lrp ligand binding
Beta-lactamase class A catalytic domain-containing protein
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
Essential for prephenate dehydratase activity
Alanyl-transfer RNA synthetases family profile
Glycine cleavage T-protein C-terminal barrel
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-111)
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Pyrroline-5-carboxylate reductase dimerisation
Glycosyl transferase family 3 N-terminal
Inosine/uridine-preferring nucleoside hydrolase
Saccharopine dehydrogenase-like C-terminal
Fibronectin type III domain-containing protein
4'-phosphopantetheinyl transferase N-terminal
Threonine/serine exporter-like N-terminal
Pyrimidine nucleoside phosphorylase C-terminal
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Increases nucleophilicity of active site Cys
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
RlpA-like protein double-psi beta-barrel
Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Putative glycogen debranching enzyme N-terminal
Gp5/Type VI secretion system Vgr protein OB-fold
Important for beta-aspartyl-AMP intermediate formation
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Peptide methionine sulphoxide reductase MsrA
Transition state stabilizer; via amide nitrogen
Pyruvate phosphate dikinase AMP/ATP-binding
Cytochrome oxidase subunit II copper A binding
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Phosphoribosylformylglycinamidine synthase linker
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Interaction with polymerase core subunit RpoC
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Protein O-mannosyl-transferase C-terminal four TM
Gram-positive cocci surface proteins LPxTG domain-containing protein
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Glutathionylspermidine synthase pre-ATP-grasp-like
Cysteine sulfenic acid (-SOH) intermediate
NIF system FeS cluster assembly NifU C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Phosphotransferase system enzyme I N-terminal
Heme-copper oxidase subunit III family profile
Electron transfer via tryptophanyl radical
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
N,N-dimethylformamidase beta subunit-like C-terminal
Styrene monooxygenase StyA putative substrate binding
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Nucleophile; cysteine thiosulfonate intermediate
Phosphoadenosine phosphosulphate reductase
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Cation-transporting P-type ATPase C-terminal