CD2 antigen cytoplasmic tail-binding protein 2 homolog
Lipid storage droplets surface-binding protein 1
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Glycoprotein 3-alpha-L-fucosyltransferase A
Helical; Signal-anchor for type II membrane protein
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Neurotransmitter-gated ion-channel ligand-binding
Neurotransmitter-gated ion-channel transmembrane
For molybdenum cofactor biosynthesis protein C activity
Molybdenum cofactor biosynthesis protein 1
Molybdenum cofactor biosynthesis protein A
Anaphase-promoting complex subunit 4-like WD40
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
In mitoguardian; progressive neurodegeneration in the eye caused by mitochondrial defects. Abolishes localization to the mitochondrion.
Mitogen-activated protein kinase kinase kinase 7
In bnch(N); leads to storage in yolk spheres during oogenesis and results in widespread accumulation of enlarged lysosomal and late endosomal inclusions.
Major facilitator superfamily (MFS) profile
Glycine cleavage T-protein C-terminal barrel
Receptor ligand binding region domain-containing protein
Potential E3 ubiquitin-protein ligase ariadne-2
Chromodomain-helicase-DNA-binding protein Mi-2 homolog
Coiled-coil and C2 domain-containing protein 1-like
LMBR1 domain-containing protein 2 homolog
Constitutively associates with the 40S ribosomal subunit.
Does not affect development. Viable but with reduced body and bristle size; when associated with L-38 or T-77.
Embryonic lethal. Viable but with reduced body and bristle size; when associated with L-146.
Larval lethal. Viable but with reduced body and bristle size; when associated with L-146.
Abolishes methylation and interaction with tud. Does not affect piRNA binding.
Putative catalytic mutant. Enhances meiotic drive.
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial
In strain: Riv04, Riv14, Riv16, Riv17, Riv18, Riv35, Riv59 and Wisconsin.
Cysteine sulfenic acid (-SOH) intermediate
No effect on methionine sulfoxide reductase activity and still lacks methionine oxidase activity; when associated with S-232.
No effect on methionine sulfoxide reductase activity and still lacks methionine oxidase activity; when associated with S-246.
Peptide methionine sulphoxide reductase MsrA
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Iron/zinc purple acid phosphatase-like C-terminal
DDB1- and CUL4-associated factor 10 homolog
cAMP-dependent protein kinase catalytic subunit 2
Ubiquitin carboxyl-terminal hydrolase Usp2
GDP-fucose protein O-fucosyltransferase 1
G-protein coupled receptors family 1 profile
Reduces enzyme activity towards dA, dG, dT and dC about 5-fold.
Reduces enzyme activity towards dT and dC about 500-fold. Reduces enzyme activity towards dG about 3900-fold. Reduces enzyme activity towards dA about 900-fold.
Eukaryotic translation initiation factor 2 subunit 1
Helical; Anchor for type IV membrane protein
DNA/RNA non-specific endonuclease domain-containing protein
In isoform A, isoform B, isoform G and isoform H.
Loss of thioredoxin-dependent activity, 80% DTT-dependent activity.
Loss of thioredoxin-dependent activity, 81% DTT-dependent activity.
Loss of thioredoxin-dependent activity, 85% DTT-dependent activity.
Thioredoxin-dependent activity reduced, but no change in DTT-dependent activity.
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
GPI ethanolamine phosphate transferase 2 C-terminal
In esc1; induces homeotic transformation; when associated with F-64.
In esc1; induces homeotic transformation; when associated with R-240.
Strongly reduces phosphorylation and the interaction with E(z).
Pyridoxamine 5'-phosphate oxidase putative
60 kDa heat shock protein homolog 2, mitochondrial
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Transcription initiation factor TFIID subunit 10b
In Z3-0437; induces female and male sterility and abolishes T-119 phosphorylation of H2A in the oocyte.
Abolishes interaction with wg and causes significant reduction of 100 kDa form which is likely to be the heparan sulfate-modified form; when associated with A-287 and A-288.
Abolishes interaction with wg and causes significant reduction of 100 kDa form which is likely to be the heparan sulfate-modified form; when associated with A-331 and A-332.
Protein transport protein Sec61 gamma-2 subunit
Beta-hexosaminidase eukaryotic type N-terminal
Putative fatty acyl-CoA reductase CG8306
Small ribosomal subunit protein uS15 N-terminal
In Msh4-4; abnormalities in sense organ precursor (SOP) cells and their progeny. Chordotonal organs contain fewer neurons and glial cells and migration of the progeny cells derived from the SOPs in embryos are significantly desynchronized among different segments.
Gamma tubulin complex component protein N-terminal
Putative serine/threonine-protein kinase STE20-like
Translation factor waclaw, mitochondrial
Probable RNA 3'-terminal phosphate cyclase-like protein
Transcription factor kayak, isoforms A/B/F
Transcription factor kayak, isoforms D/sro
Probable 26S proteasome complex subunit sem1
Mediator of RNA polymerase II transcription subunit 12
Trypsin delta/gamma-like protein CG30031
Heterogeneous nuclear ribonucleoprotein 87F
Ankyrin repeat and KH domain-containing protein mask
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic
In allele GPDH-AT198, allele GPDH-ACB62 and allele GPDH-S.
Cation-transporting P-type ATPase C-terminal
Enhancer of mRNA-decapping protein 4 homolog
Serine/threonine specific protein phosphatases
Adipocyte plasma membrane-associated protein Hemomucin
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Activator of Hsp90 ATPase AHSA1-like N-terminal
Basic helix-loop-helix neural transcription factor TAP
Prokaryotic-type class I peptide chain release factors
2-oxoglutarate dehydrogenase E1 component N-terminal
Anaphase-promoting complex subunit 4 long
PHD finger-like domain-containing protein 5A
NAD-dependent histone deacetylase sirtuin-1
Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit
Condensin-2 complex subunit H2 C-terminal
TATA box binding protein associated factor (TAF) histone-like fold
Strong defects in abdomen and oogenesis.
Strong defects in abdomen and oogenesis. Reduces binding of zinc. Complete loss of zinc-binding and loss of function; when associated with Y-319.
Strong defects in abdomen and oogenesis. Reduces binding of zinc. Complete loss of zinc-binding and loss of function; when associated with Y-354.
Strong defects in oogenesis. Weak defects in abdomen.
In rec3; temperature-sensitive allele. Recombination-defective.
Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal
In strain: Berkeley, JP-5, JP-35, JP-55, JP-65 and KN-12.
In strain: Berkeley, JP-5, JP-35, JP-55, JP-65, JP-70, KN-12 and KN-21.
In strain: Berkeley, JP-5, JP-35, JP-55, JP-75, KN-12 and Oregon-R.
In strain: JP-1, JP-15, JP-84, KO140 and KN-27.
In strain: JP-75, KN-17, KN-21, KN-22 and L16.
Mediator of RNA polymerase II transcription subunit 7
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2
receptor protein serine/threonine kinase
Heparan sulfate 2-O-sulfotransferase pipe
Exocyst complex component Sec3 PIP2-binding N-terminal
Asymmetric dimethylarginine; by autocatalysis
Probable histone-arginine methyltransferase CARMER
Ubiquitin carboxyl-terminal hydrolase nonstop
Helical; Voltage-sensor; Name=Segment S4
Potassium voltage-gated channel protein Shaw
Lowers pKa of C-terminal Cys of first active site
Lowers pKa of C-terminal Cys of second active site
Loss of binding to Mad1 and reduction of closed-Mad2 levels at unattached kinetochores; when associated with D-1259; D-1302 and D-1338 or with D-1259 and D-1338.
Loss of binding to Mad1 and reduction of closed-Mad2 levels at unattached kinetochores; when associated with D-1259; D-1302 and D-1390 or with D-1259 and D-1390.
Loss of binding to Mad1 and reduction of closed-Mad2 levels at unattached kinetochores; when associated with D-1259; D-1338 and D-1390.
Loss of binding to Mad1 and reduction of closed-Mad2 levels at unattached kinetochores; when associated with D-1302; D-1338 and D-1390 or with D-1338 and D-1390.
Retains binding to Mad1; when associated with A-1259; A-1302 and A-1338.
Retains binding to Mad1; when associated with A-1259; A-1302 and A-1390.
Retains binding to Mad1; when associated with A-1259; A-1338 and A-1390.
Retains binding to Mad1; when associated with A-1302; A-1338 and A-1390.
In strain: Canton-S, KY02010G20, KY02013G20 and KY02073G20.
In strain: Canton-S, KY02010G20, KY02073G20 and KY02013G20.
In strain: Canton-S, KY02013G20 and KY02073G20.
G-protein coupled receptors family 3 profile
G-protein coupled receptors family 3 profile domain-containing protein
H/ACA ribonucleoprotein complex subunit 4
tRNA (34-2'-O)-methyltransferase regulator WDR6
Damage-control phosphatase ARMT1-like metal-binding
Alpha galactosidase A C-terminal beta-sandwich
Chitin-binding type-2 domain-containing protein
Contains conserved residues essential for 3' -> 5' exonuclease activities
Basic helix-loop-helix transcription factor amos
Sodium/calcium exchanger membrane region
Gram-negative bacteria-binding protein 2
In strain: Netherlands line N07 and Netherlands line N14.
Vacuolar protein sorting-associated protein 13 DH-like
Vacuolar protein sorting-associated protein 13 extended chorein
Eukaryotic translation initiation factor 5
Mediator of RNA polymerase II transcription subunit 28
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
TATA box-binding protein-associated factor RNA polymerase I subunit B
N-alpha-acetyltransferase 35, NatC auxiliary subunit homolog
Eukaryotic translation initiation factor 6
Abolishes N-alpha-acetyltransferase activity; impaired sister chromatid cohesion during mitosis.; when associated with A-84.
Abolishes N-alpha-acetyltransferase activity; impaired sister chromatid cohesion during mitosis.; when associated with F-124.
Receptor-mediated endocytosis protein 6 homolog
Muscle and wing mutant phenotype; allele flw-1.
Semi lethal, adult escapers exhibit muscle and wing mutant phenotype; allele flw-6.
Serine/threonine-protein phosphatase beta isoform
Aromatic amino acid beta-eliminating lyase/threonine aldolase
DNA repair and recombination protein RAD54-like
No ATPase or chromatin remodeling activity.
Partial ATPase and low chromatin remodeling activity.
Reduced ATPase activity and loss of chromatin remodeling and strand pairing activities.
Required for chromatin remodeling, strand pairing activities and coupling of ATPase activity
Nose resistant-to-fluoxetine protein N-terminal
Nose resistant-to-fluoxetine protein N-terminal domain-containing protein
Trafficking protein particle complex subunit 11
Trafficking protein particle complex subunit 11 C-terminal
In strain: Usa1, Zim15, Zim18, Zim22, Zim39 and Zim42.
In strain: Usa3, Usa16, Zim7, Zim10, Zim13, Zim16, Zim18, Zim22, Zim39, Zim41, Zim42, Z36 and Z50.
In strain: Usa3, Zim7, Zim10, Zim13, Zim16, Zim18, Zim22, Zim39, Zim41, Zim42, Z36 and Z50.
In strain: Usa8, Usa12, Usa16, Zim18, Zim39 and Zim41.
In strain: Usa8, Usa12, Usa16, Zim7, Zim10, Zim13, Zim15, Zim16, Zim18, Zim22, Zim39, Zim42, Z36 and Z50.
In strain: Zim10, Zim13, Zim16, Zim18, Zim39, Z36 and Z50.
Sphingomyelin phosphodiesterase C-terminal
Mediator of RNA polymerase II transcription subunit 17
In swmF15; recessive lethal and induces reduced fucosylation levels.
Glycosyl-hydrolase family 116 N-terminal
Glycosyl-hydrolase family 116 catalytic region
Mediator of RNA polymerase II transcription subunit 21
Impairs function in completion of female meiosis. Loss of function in completion of female meiosis; when associated with A-215.
Loss of function in completion of female meiosis.
Loss of function in completion of female meiosis. Loss of function in completion of female meiosis; when associated with A-219.
No effect on function in completion of female meiosis.
Slightly impairs function in completion of female meiosis.
Vacuolar protein-sorting-associated protein 36
Dynein regulatory complex protein 1 homolog
Dynein heavy chain ATP-binding dynein motor region
Dynein heavy chain hydrolytic ATP-binding dynein motor region
Alanine--glyoxylate aminotransferase 2-like
Adenosine 3'-phospho 5'-phosphosulfate transporter 1
Abolishes interaction with eIF4E1; when associated with 586-A-A-587.
Abolishes interaction with eIF4E1; when associated with A-581.
Eukaryotic translation initiation factor 4E-binding protein Mextli
Acetylcholine receptor subunit alpha-like 1
In amonC241Y: Partial embryonic lethality and defective larval growth with no pupariation or survival to adulthood. Defective Akh processing. Does not affect sli processing.
In amonC254Y: Partial embryonic lethality and defective larval growth with no pupariation or survival to adulthood.
In amonG367V: Partial embryonic lethality and defective larval growth with no pupariation or survival to adulthood.
In amonG473R: Partial embryonic lethality and defective larval growth with no pupariation or survival to adulthood.
In amonS557L1 and amonS557L2: Partial embryonic lethality and defective larval growth with no pupariation or survival to adulthood.
Transcription factor CBF/NF-Y/archaeal histone
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
BPTI/Kunitz inhibitor domain-containing protein
Platelet-derived growth factor (PDGF) family profile
Gly-cisPro motif, important for rejection of L-amino acids
EGF domain-specific O-linked N-acetylglucosamine transferase
Calcium release-activated calcium channel protein 1
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
DNA polymerase subunit gamma-1, mitochondrial
Defects in mitochondrial DNA (mtDNA) replication and synthesis results in larval lethality at the third instar stage. Displays increased exonuclease activity and shows replicative stalling, particularly at dATP insertion sites. Defective replication and synthesis results in decreased levels of mtDNA but does not result in multiple linear deletions in mtDNA. No effect on DNA binding.
Defects in mitochondrial DNA (mtDNA) replication and synthesis results in larval lethality at the third instar stage. Larvae 5 days old, display a severe decrease in mtDNA levels and a significant reduction in body weight. Does not result in linear deletions of mtDNA.
Defects in mitochondrial DNA (mtDNA) replication and synthesis results in pupal lethality. Only half of the mutants survive to the pupal stage but die shortly afterwards. Larvae display an accumulation of point mutations and linear deletions of mtDNA. No decrease in larvae body weight. Unable to rescue the defective clearance of paternal mitochondrial nucleoids in mutants.
Defects in mitochondrial DNA (mtDNA) replication and synthesis results in the death of most mutants at the third instar stage. Only two percent survive to the pupal stage but die shortly afterwards. Five day old larvae display a severe decrease in mtDNA levels and a significant reduction in body weight.
In KDF; reduction in polymerase activity.
In PKL; severe reduction in polymerase activity.
In SYW; severe reduction in polymerase activity.
In YED; slight reduction in polymerase activity.
Loss of mitochondrial DNA which disrupts mitochondrial morphology, leads to higher mitochondrial density in proximal nerves and muscles as well as increased flux of bidirectional mitochondrial axonal transport; when associated with Ala-595.
Loss of mitochondrial DNA which disrupts mitochondrial morphology; larval brains are smaller due to defective cell proliferation leading to death at the pupal stage. Leads to higher mitochondrial density in proximal nerves and muscles as well as increased flux of bidirectional mitochondrial axonal transport; when associated with 1085-S--S-1145 DEL.
Partially rescues the defective clearance of paternal mitochondrial nucleoids in mutants.
Severe defects in mitochondrial DNA (mtDNA) replication and synthesis results in larval lethality at the third instar stage. Exonuclease activity is increased, and displays replicative stalling, particularly at dATP insertion sites, and decreased DNA binding. Defective replication and synthesis results in decreased levels of mtDNA but does not result in multiple linear deletions in mtDNA.
Severe reduction in polymerase activity.
Slight reduction in polymerase activity.
Abolishes interaction with GATA-type zinc fingers.
Transforms the C2HC-type zinc finger into a C2H2-type, leading to abolish interaction with pnr.
Regulator of telomere elongation helicase 1 homolog
Abolishes methyltransferase activity of the Esc/E(z) complex.
Strongly reduces methyltransferase activity of the Esc/E(z) complex.
Probable arginine--tRNA ligase, cytoplasmic
In Src42A-myri; 63% of mutants die during embryogenesis. In embryos, leading edge cell morphology is irregular, the actomyosin cable is disrupted and dorsal closure is delayed. Stage 16 embryos, which have undergone dorsal closure, have an irregular arrangement of epidermal cells.
Leucine-rich repeat and calponin homology domain-containing protein
Rad21/Rec8-like protein C-terminal eukaryotic
Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial
Solute carrier family 35 member B1 homolog
Probable Rho GTPase-activating protein CG5521
Tyrosine-protein kinase transmembrane receptor Ror
Mitochondrial cytochrome c oxidase subunit VIc/VIIs
Helical; Voltage-sensor; Name=S4 of repeat I
Helical; Voltage-sensor; Name=S4 of repeat II
Helical; Voltage-sensor; Name=S4 of repeat III
Helical; Voltage-sensor; Name=S4 of repeat IV
Voltage-dependent L-type calcium channel IQ-associated
Peptidase M1 membrane alanine aminopeptidase
Interchain (between heavy and light chains)
Nedd8-activating enzyme E1 regulatory subunit
Inactive non-canonical poly(A) RNA polymerase protein Trf4-2
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
DNA/pantothenate metabolism flavoprotein C-terminal
Putative peptidyl-prolyl cis-trans isomerase dodo
Inosine/uridine-preferring nucleoside hydrolase
Superoxide dismutase copper/zinc binding
Superoxide dismutase copper/zinc binding domain-containing protein
Thioredoxin domain-containing protein 5 homolog
cGMP-dependent protein kinase, isozyme 1
Probable methylthioribulose-1-phosphate dehydratase
G patch domain and ankyrin repeat-containing protein 1 homolog
Bicarbonate transporter-like transmembrane
Protein is locked into the activated GTP-bound state.
Inhibits wing growth. Reduces phosphorylation by Ack; when associated with A-227, A-423, A-679 and A-766.
Inhibits wing growth. Reduces phosphorylation by Ack; when associated with A-227, A-423, A-679, and A-1103.
Inhibits wing growth. Reduces phosphorylation by Ack; when associated with A-227, A-423, A-766 and A-1103.
Inhibits wing growth. Reduces phosphorylation by Ack; when associated with A-227, A-679, A-766 and A-1103.
Inhibits wing growth. Reduces phosphorylation by Ack; when associated with A-423, A-679, A-766 and A-1103.
Probable cytochrome P450 301a1, mitochondrial
Probable cardiolipin synthase (CMP-forming)
Ionotropic glutamate receptor C-terminal
Ionotropic glutamate receptor L-glutamate and glycine-binding
Shows high levels of reactive oxygen species (ROS) and accumulation of lipid droplets in pigment and epithelial glia. Lipid droplet accumulation occurs early, prior to the onset of neurodegeneration.
Carboxylesterase type B domain-containing protein
U1 small nuclear ribonucleoprotein 70 kDa
Coiled-coil domain-containing protein lobo
G-protein coupled receptors family 2 profile 2
Probable G-protein coupled receptor Mth-like 10
Dominant-negative mutant that inhibits Notch signaling.
Loss of function. Abolishes homomultimerization; when associated with A-571.
Loss of function. Abolishes homomultimerization; when associated with A-574.
Transcription termination factor, mitochondrial
Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
Minichromosome loss protein Mcl1 middle region
Large ribosomal subunit protein uL15/eL18
No effect on VLCA levels. Increases dimerization. Induces a high level of ROS and severe axonal loss. Lethal.
Probable peroxisomal acyl-coenzyme A oxidase 1
Transmembrane emp24 domain-containing protein eca
Testis-specific zinc finger protein topi
Mitochondrial tRNA-specific 2-thiouridylase 1
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Ubiquitin carboxyl-terminal hydrolase family 1 cysteine active-site
Ubiquitin fusion degradation protein 1 homolog
Abolishes interaction with cup and mxt; when associated with A-107.
Abolishes interaction with cup and mxt; when associated with A-123.
Abolishes interaction with mxt, reduces binding to Thor and 4E-T, and does not affect interaction with cup.
Disrupts interaction with cup, eIF4G and mxt.
Eukaryotic translation initiation factor 4E1
Histone deacetylase complex subunit SAP130 C-terminal
Large ribosomal subunit protein uL18 C-terminal eukaryotes
Aminoacyl-transfer RNA synthetases class-II family profile
Peptidoglycan recognition protein family
S phase cyclin A-associated protein in the endoplasmic reticulum N-terminal
In mus205; hypersensitive to alkylating agents and UV, but not sensitive to ionising radiation. In somatic cells, no effect on methyl methane sulfonate-induced mutations and homologous recombination. In germ cells, no effect on mutability by X-rays, NQO and alkylating agents.
Gamma tubulin complex component C-terminal
Gamma-tubulin complex component 4 homolog
Guanine nucleotide-binding protein subunit gamma-1
U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein
Ribosomal RNA small subunit methyltransferase NEP1
Serine/threonine-protein phosphatase alpha-2 isoform
Alpha-glycerophosphate oxidase C-terminal
Mitochondrial E3 ubiquitin protein ligase 1
Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial
In Ala5: Induces apoptosis; when associated with A-121, A-148, A-180 and A-228.
In Ala5: Induces apoptosis; when associated with A-121, A-148, A-180 and A-251.
In Ala5: Induces apoptosis; when associated with A-121, A-148, A-228 and A-251.
In Ala5: Induces apoptosis; when associated with A-121, A-180, A-228 and A-251.
In Ala5: Induces apoptosis; when associated with A-148, A-180, A-228 and A-251.
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Mitochondrial import inner membrane translocase subunit Tim9
Mitochondrial import inner membrane translocase subunit Tim8
Histone deacetylase complex subunit SAP18
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
Trafficking kinesin-binding protein C-terminal
Trafficking kinesin-binding protein milt
von Hippel-Lindau disease tumour suppressor beta
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Transcription initiation factor TFIID component TAF4 C-terminal
Galactose-1-phosphate uridyl transferase C-terminal
Galactose-1-phosphate uridyl transferase N-terminal
Probable galactose-1-phosphate uridylyltransferase
Acetylcholine receptor subunit alpha-like 2
Insulin-like growth factor-binding protein complex acid labile subunit
Peptidase S9 prolyl oligopeptidase catalytic
Abolishes deubiquitinase activity without affecting the interaction with Asx.
Ubiquitin carboxyl-terminal hydrolase calypso
Nuclear protein localization protein 4 homolog
PAN2-PAN3 deadenylation complex subunit PAN3
Loss of function; when associated with 516-A-A-517.
Loss of function; when associated with 517-N-N-517.
Loss of function; when associated with A-1030.
Loss of function; when associated with N-1030.
Gamma-butyrobetaine hydroxylase-like N-terminal
O-(5'-phospho-DNA)-tyrosine intermediate
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Abolishes function in photoreceptor cell development.
DNA methyltransferase 1-associated protein 1
Loss of function; when associated with C-59.
Loss of function; when associated with R-68.
Large ribosomal subunit protein uL10-like insertion
Forms round eggs. Intracellular vkg accumulates at the basal surface of follicle cells, and vkg levels are reduced in the basal membrane.
Procollagen-lysine,2-oxoglutarate 5-dioxygenase
Abolishes interaction with polo and ability to maintain G2 arrest.
Decreased degradation during the oocyte-to-embryo transition.
In strain: NC335, NC390, NC397 and NC774.
No effect on degradation during the oocyte-to-embryo transition.
No effect on degradation during the oocyte-to-embryo transition; when associated with A-193.
No effect on degradation during the oocyte-to-embryo transition; when associated with A-95.
Protein bunched, class 1/class 3/D/E isoforms
BLOC-2 complex member HPS3 central region
Microsomal triacylglycerol transfer protein
GPI ethanolamine phosphate transferase 1 C-terminal
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1
Putative inactive polypeptide N-acetylgalactosaminyltransferase 12
Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate
Schiff-base intermediate with dihydroxyacetone-P
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Juvenile hormone acid O-methyltransferase
Fibrinogen C-terminal domain-containing protein
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
Inhibits zymogen cleavage and thus activation and spz processing.
Interchain (between light and heavy chains)
Abolishes phosphorylation by Akt1, nuclear localization, and transcriptional activity.
In isoform A, isoform B, isoform C and isoform E.
Malpighian tubules empty into a single large sack that is attached to the hindgut and no ureters are evident. Distal segments of the tubules are tubular but fail to elongate or undergo cell rearrangement, resulting in tubules that are shorter and wider than normal. Hindguts are normal in shape but shortened.
No effect on phosphorylation by Akt1; no effect on transcriptional activity.
Slightly increases transcriptional activity.
Prolyl 4-hydroxylase alpha-subunit N-terminal
Mitochondrial ribonuclease P protein 1 homolog
Putative lipoyltransferase 2, mitochondrial
In mus308-094 mutant; mutant females produce ventralized egg shells.
In mus308-2255 mutant; mutant females produce ventralized egg shells; when associated with D-455.
In mus308-2255 mutant; mutant females produce ventralized egg shells; when associated with H-811.
In mus308-660 mutant; mutant females produce ventralized egg shells.
Probable cytosolic iron-sulfur protein assembly protein Ciao1
Glycosyltransferase subfamily 4-like N-terminal
Thymidylate synthase/dCMP hydroxymethylase
BLOC-1-related complex subunit 6 C-terminal helix
Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal
In EA 111; results in temperature-sensitive defects in dorsoventral patterning.
In EA 125.3; results in ventralized embryos.
In EA 12A; results in weakly ventralized embryos with ventral denticle bands that are approximately normal in width and the filzkorper have the normal tubular morphology.
In EA 161.13; results in weakly ventralized embryos with ventral denticle bands that are approximately normal in width and the filzkorper have the normal tubular morphology.
In EA 1; results in completely dorsalized embryos.
In EA 20N; results in extreme lateralized embryonic pattern where the most dorsal pattern elements (e.g. dorsal cuticles) and the most ventral pattern element (mesoderm) are absent.
In EA 5.13; results in extreme lateralized embryonic pattern where the most dorsal pattern elements (e.g. dorsal cuticle) and the most ventral pattern element (mesoderm) are absent.
In EA 5022; probable loss of catalytic activity results in partially defective dorsoventral patterning; in gastrulation, shows an intermediate ventralization with the headfold prominent on the dorsal side and some anteriorward displacement of posterior cells along the dorsal site; in late embryogenesis, shows partial filzkorper and head skeleton, as well as ventral denticles erroneously in dorsal position.
In EA 818; results in temperature-sensitive defects in dorsoventral patterning.
In EA 83I and EA 4102; results in ventralized embryos.
In EA 84B; results in weakly ventralized embryos with ventral denticle bands that are approximately normal in width and the filzkorper have the normal tubular morphology.
In EA 8; results in completely dorsalized embryos.
In EAQGDS; results in lateralised embryos.
Loss of catalytic activity results in defective dorsoventral patterning characterized by a complete dorsalization in which there is no ventral furrow or headfold, cells at the posterior do not migrate, and multiple symmetric folds appear along the anterior-posterior axis of the embryo.
Probable loss of calcium binding which might affect catalytic activity. Results in defective dorsoventral patterning showing a complete dorsalization in which there is no ventral furrow or headfold, cells at the posterior do not migrate, and multiple symmetric folds appear along the anterior-posterior axis of the embryo.
Probable loss of catalytic activity results in partially defective dorsoventral patterning; during gastrulation, shows defective ventralization; in late embryogenesis results in moderately dorsalized embryos presenting defective lateral filzkorper, head skeleton and ventral denticles.
ATP synthase subunit alpha, mitochondrial
Putative inorganic phosphate cotransporter
Eukaryotic translation initiation factor 3 subunit D-1
Exocyst complex component Sec8 N-terminal
Putative sodium-dependent multivitamin transporter
Cysteinyl-selenocysteine (Cys-Sec); redox-active
Poly(U)-binding-splicing factor half pint
3,4-dihydroxyphenylacetaldehyde synthase
Enzymatic shift from L-dopa decarboxylation-oxidative deamination to L-Dopa decarboxylation.
Cationic amino acid transporter C-terminal
Inhibitor of nuclear factor kappa-B kinase subunit beta
Transcription termination factor 3, mitochondrial
Putative oligosaccharyltransferase complex subunit CG9662
WD repeat-containing and planar cell polarity effector protein fritz
Potassium channel voltage dependent KCNQ C-terminal
Intron-binding protein aquarius N-terminal
Dynein regulatory complex protein 1/2 N-terminal
Peptidase M14 carboxypeptidase A domain-containing protein
Cell division control protein 73 C-terminal
MD-2-related lipid-recognition domain-containing protein
Vacuolar ATPase assembly integral membrane protein VMA21 homolog
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
ABC-type uncharacterised transport system
Probable aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Complex I intermediate-associated protein 30, mitochondrial
Protein-serine O-palmitoleoyltransferase porcupine
Extracellular superoxide dismutase [Cu-Zn]
Fails to be recruited at the membrane upon activation.
In nac1; abolishes GDP-fucose transport into the Golgi lumen. Shows lack of both core alpha-1,3- and alpha-1,6-linked fucose residues on N-glycans. Reduces neural expression of the HRP epitope. Does not affect subcellular localization to the Golgi apparatus.
Cation-transporting P-type ATPase N-terminal
In allele ATP-alpha-dts1; homozygous lethal and temperature dependent bang sensitive paralysis, shortened life span and neurodegeneration when heterozygous.
In allele ATP-alpha-dts2; homozygous lethal and temperature dependent bang sensitive paralysis, shortened life span and neurodegeneration when heterozygous.
In isoform 2, isoform 3, isoform 6 and isoform 7.
Sodium/potassium-transporting ATPase subunit alpha
Little elongation complex subunit 2 C-terminal
Transcriptional activator cubitus interruptus
Transcriptional repressor cubitus interruptus
Dihydroorotate dehydrogenase (quinone), mitochondrial
Greatly reduces complex helicase activity.
Unconventional prefoldin RPB5 interactor-like protein
Increases numbers of granules containing Nup358/RanBP2 and annulate lamellae containing nuclear pore complex components in egg and nurse cells.
Reduces numbers of granules containing Nup358/RanBP2 and annulate lamellae containing nuclear pore complex components in egg and nurse cells.
Ornithine aminotransferase, mitochondrial
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
Phosphomimetic mutant that fully rescues climbing defects and significantly improves flight defects, and thorax and wing posture phenotypes in Pink1 mutants. No effect on acyl-CoA dehydrogenase activity.
Prevents phosphorylation by Pink1. Does not rescue climbing and flight defects in Pink1 mutants.
Sodium-dependent nutrient amino acid transporter 1
Displays defects in aligning on the meiotic spindle.
In strain: Kronenbourg, Madibou4, Primus20, Primus25, ZH34 and ZH83.
7SK snRNA methylphosphate capping enzyme bin3
Glycosyl hydrolase family 30 beta sandwich
Transient receptor potential cation channel trpm
Probable cytosolic Fe-S cluster assembly factor CG17683
Important for catalytic activity; essential for amidase activity and zinc hydrate coordination
In strain: Draveil, Loua, Monty5, P.bourg, Tahiti, Texas and ZW141.
In svr-1; Adult wings are pointed and have shortened veins. Displays decreased cold sensitivity and fails to suppress courtship with previously mated females indicating deficits in long-term memory.
In svr-poi; Adult wings are smaller, pointed and have shortened veins. Displays decreased cold sensitivity and fails to suppress courtship with previously mated females indicating deficits in long-term memory.
Probable trafficking protein particle complex subunit 2
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Chromatin accessibility complex 16kD protein
When in a heterodimer with Chrac-14, does not affect DNA binding or Acf nucleosome sliding activity.
When in a heterodimer with Chrac-14, enhances DNA binding.
Voltage-gated Na+ ion channel cytoplasmic
In mtSSB45-1; significant reduction in mitochondrial DNA (mtDNA) copy number and reduced recovery of mtDNA depletion induced by ethidium bromide.
In mtSSB45-2; reduced mitochondrial DNA (mtDNA) copy number and reduced recovery of mtDNA depletion induced by ethidium bromide.
In mtSSBalpha1; significant reduction in mitochondrial DNA (mtDNA) copy number and reduced recovery of mtDNA depletion induced by ethidium bromide.
In mtSSBloop12; significant reduction in mitochondrial DNA copy number.
In mtSSBloop23; significant reduction in mitochondrial DNA copy number. No effect on ability to stimulate the activity of the polymerase PolG1.
No decrease in DNA synthesis by the polymerase PolG1. Severe decrease DNA synthesis by the polymerase PolG1 and decreased DNA binding; when associated with T-85.
No effect on DNA synthesis by the polymerase PolG1.
Reduced DNA synthesis by the polymerase PolG1.
Reduced DNA synthesis by the polymerase PolG1. Severe decrease in the stimulation of DNA synthesis by the polymerase PolG1 and decreased DNA binding; when associated with A-91.
Single-stranded DNA-binding protein, mitochondrial
Probable G-protein coupled receptor Mth-like 3
Facilitated trehalose transporter Tret1-2 homolog
Vacuolar protein-sorting-associated protein 25
5-glutamyl coenzyme A thioester intermediate
Succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial
Cathepsin propeptide inhibitor domain-containing protein
Large ribosomal subunit protein uL23 N-terminal
Pre-mRNA processing factor 4 (PRP4)-like
Zinc finger CCCH domain-containing protein 15 homolog
Inward rectifier potassium channel C-terminal
Potassium channel inwardly rectifying transmembrane
Interaction with phosphoserine on interacting protein
Endoplasmic reticulum vesicle transporter C-terminal
Endoplasmic reticulum vesicle transporter N-terminal
Ragulator complex protein LAMTOR2 homolog
Transcription initiation factor IIA alpha chain
Transcription initiation factor IIA beta chain
Transcription initiation factor IIA subunit 1
Loss of zinc fingers domains results in defects in cuticle elasticity, reduced sclerotization of the head skeleton and ventral epidermal denticles, and disruption of multiple aspects of tube morphogenesis in terminal cells including seamless tube growth, shape, and integrity.
Probable loss of zinc ion coordination in the second zinc finger results in defects in cuticle elasticity, reduced sclerotization of the head skeleton and ventral epidermal denticles, and disruption of multiple aspects of tube morphogenesis in terminal cells including seamless tube growth, shape, and integrity.
Mitochondrial apoptosis-inducing factor C-terminal
Putative apoptosis-inducing factor 1, mitochondrial
Decrease in response to SP. Response to MIP is less affected.
Ribosome quality control complex subunit NEMF homolog
N-sulphoglucosamine sulphohydrolase C-terminal
NF-kappa-B inhibitor-interacting Ras-like protein
In SAK-ND; impairs interaction with SCF-slmb ubiquitin ligase complex and subsequent ubiquitination; when associated with A-292.
In SAK-ND; impairs interaction with SCF-slmb ubiquitin ligase complex and subsequent ubiquitination; when associated with A-297.
In vnd-29; disrupts neuroblast development.
ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic
Molybdenum cofactor synthesis protein cinnamon
Seamless tube overgrowth at terminal cell tip branches.
Gustatory and pheromone receptor 39a, isoform A
Gustatory and pheromone receptor 39a, isoform B
Gustatory and pheromone receptor 39a, isoform C
Gustatory and pheromone receptor 39a, isoform D
Probable G-protein coupled receptor Mth-like 8
Inhibits interaction with Rac1 but not Rho1, does not alter subcellular localization and is able to rescue loss-of-function phenotype lethality.
S-adenosyl-L-homocysteine hydrolase NAD binding
Abolishes the ability to cause laterality defects upon overexpression.
Abolishes the ability to cause laterality defects upon overexpression; when associated with A-120 and A-166.
Abolishes the ability to cause laterality defects upon overexpression; when associated with A-120 and A-395.
Abolishes the ability to cause laterality defects upon overexpression; when associated with A-166 and A-395.
No effect on the ability to cause laterality defects upon overexpression.
Mediator complex subunit Med13 C-terminal
Mediator complex subunit Med13 N-terminal
Mediator of RNA polymerase II transcription subunit 13
Conserved oligomeric Golgi complex subunit 1
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-132 in APG5)
In drm2; foregut proventriculus morphologically and functionally defective.
In drm4; foregut proventriculus morphologically and functionally defective.
In drm5; foregut proventriculus morphologically and functionally defective.
In drm6; foregut proventriculus and hindgut morphologically and functionally defective. Abolishes lin binding. Abolishes lin-inhibiting activity.
Reduces lin binding. No effect on lin-inhibiting activity.
Deformed epidermal autoregulatory factor 1
Mediator of RNA polymerase II transcription subunit 20
Peptidase M17 leucyl aminopeptidase N-terminal
Tyrosine-protein kinase transmembrane receptor Ror2
Nuclear localization and induces transcriptional activity; when associated with A-527.
Nuclear localization and induces transcriptional activity; when associated with A-530.
Dendritic cell-specific transmembrane protein-like
Serine/threonine-protein phosphatase 4 catalytic subunit
In isoform Female-E, isoform K and isoform Male-E.
In isoform Female-I, isoform Female-A, isoform Type-D, isoform Type-C, isoform Female-B and isoform Female-E.
In isoform Female-I, isoform Male-I, isoform Female-B and isoform Male-B.
Histone-lysine N-methyltransferase trithorax
In 3A; loss of phosphorylation. In the presence of aPKC remains localized to the cell cortex and does not display any decrease in phospholipid binding; when associated with A-656 and A-660.
In 3A; loss of phosphorylation. In the presence of aPKC remains localized to the cell cortex and does not display any decrease in phospholipid binding; when associated with A-656 and A-664.
In 3A; loss of phosphorylation. In the presence of aPKC remains localized to the cell cortex and does not display any decrease in phospholipid binding; when associated with A-660 and A-664.
In 3D; phosphomimetic mutant that displays a slight decrease in phospholipid binding and reduced cortical localization; when associated with D-656 and D-660.
In 3D; phosphomimetic mutant that displays a slight decrease in phospholipid binding and reduced cortical localization; when associated with D-656 and D-664.
In 3D; phosphomimetic mutant that displays a slight decrease in phospholipid binding and reduced cortical localization; when associated with D-660 and D-664.
In 4k/R-D; phosphomimetic mutant that displays decreased phospholipid binding and reduced cortical localization; when associated with 658-D--D-659.
In 4k/R-D; phosphomimetic mutant that displays decreased phospholipid binding and reduced cortical localization; when associated with D-666 and D-667.
Lethal giant larvae (Lgl)-like C-terminal
Phospho-regulated basic and hydrophobic (PRBH) motif
Reduced cortical localization and increased cytoplasmic localization.
Probable phenylalanine--tRNA ligase, mitochondrial
In mus308(3294); flies are unable to repair interstrand cross-links.
In mus308(D5); flies are unable to repair interstrand cross-links.
Increases sensitivity to DNA interstrand damage induced by DNA-cross-linking agents and ionizing radiation. Reduces alternative end-joining repair.
Increases sensitivity to DNA interstrand damage induced by DNA-cross-linking agents. Reduces annealing and extension of single-strand DNA molecules in vitro but does not affect end-joining frequency.
Mediator of RNA polymerase II transcription subunit 22
Abolishes guanylate cyclase activity but does not affect cell surface location.
In 3L043; complete loss of the posterior crossvein in adult wings.
Potassium voltage-gated channel protein eag
Reduced eag channel amplitude and accelerated inactivation. Does not affect binding with CASK.
In allele Shab-1; temperature-sensitive paralytic.
Potassium voltage-gated channel protein Shab
Small ribosomal subunit protein mS35 mitochondrial conserved
Immediate early response 3-interacting protein 1
H/ACA ribonucleoprotein complex non-core subunit NAF1
cAMP-dependent protein kinase catalytic subunit 3
Sodium- and chloride-dependent GABA transporter ine
Cilia- and flagella-associated protein 61 N-terminal
Abolishes cleavage from sperm and prevents release of C-terminal fragment for long-term PMR. Short-term PMR in unaffected.
Complete loss of activity; when associated with A-42. Complete loss of activity; when associated with A-42; A-43 and A-55.
Complete loss of activity; when associated with A-42; A-43 and A-51.
Complete loss of activity; when associated with A-42; A-51 and A-55.
Complete loss of activity; when associated with A-51. Complete loss of activity; when associated with A-43; A-51 and A-55.
In strain: Berkeley, M2, M26, M36, M40, M55 and SFS 3.4.
Abscisic acid G-protein coupled receptor-like
Abolished binding to S-adenosyl-L-homocysteine.
Reduced binding to S-adenosyl-L-homocysteine.
S-adenosylmethionine sensor upstream of mTORC1
Mini-chromosome maintenance complex-binding protein
INO80 complex subunit B-like conserved region
Probable tRNA (uracil-O(2)-)-methyltransferase
Loss of kinase activity. Attenuates bsk activation.
Mitogen-activated protein kinase kinase kinase
Probable cytochrome P450 12e1, mitochondrial
Serine/threonine-protein phosphatase alpha-1 isoform
Moderate decrease in catalytic activity but strongly reduces affinity for substrates I-Tyr and I2-Tyr.
Moderate decrease in catalytic efficiency and reduced affinity for substrates I-Tyr and I2-Tyr.
Significant decrease in catalytic efficiency and reduced affinity for substrates 3-iodo-L-tyrosine (I-Tyr) and 3,5-diiodo-L-tyrosine (I2-Tyr). Larvae survival is decreased when fed a diet supplemented with 100 or 200um of I-Tyr but is increased when fed a diet enriched with 3-chloro-L-tyrosine (Cl-Tyr). However, adult survival is unaffected when fed a diet supplemented with halotyrosines.
E3 ubiquitin-protein ligase APD1-4 N-terminal
E3 ubiquitin-protein ligase APD1-4 middle
Tryptophan synthase beta chain-like PALP
Transport and Golgi organization protein 6
Mitochondrial import inner membrane translocase subunit Tim13
In isoform 1, isoform 2, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7 and isoform 8.
In isoform 1, isoform 3, isoform 5, isoform 7 and isoform 9.
cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B
cGMP-dependent protein kinase, isozyme 2 forms cD5/T2
In stn-TS2; induce behavioral defects. Homozygous adults are viable but exhibit sluggish and uncoordinated behavior.
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 1
Proton donor; shared with dimeric partner
Stacks against the aromatic ring of pyridoxal phosphate and stabilizes reaction intermediates
NPC intracellular cholesterol transporter 1 homolog 1b
Eukaryotic translation initiation factor 3 subunit A
Programmed cell death protein 2 C-terminal
Polypeptide N-acetylgalactosaminyltransferase 8
2 X 24 AA repeats of L-D-L-S-V-S-P-L-A-E-L-[SP]-A-K-K-K-[YS]-[AD]-R-D-[SP]-P-P-K-P
3' overhang DNA-binding; via amide nitrogen
Putative dual specificity tyrosine-phosphorylation-regulated kinase 3 homolog
CBF1-interacting co-repressor CIR N-terminal
Inositol polyphosphate-related phosphatase
Conserved oligomeric Golgi complex subunit 2
Loss of enzymatic activity. Increased susceptibility to infections by E.cloacae. No effect on binding and polyubiquitination of imd.
Probable ubiquitin carboxyl-terminal hydrolase FAF
Glucose dehydrogenase [FAD, quinone] short protein
Glucose-methanol-choline oxidoreductase N-terminal
Serine--tRNA synthetase-like protein Slimp
Loss of activity in Myc-mediated growth in the wing and eye, and no increase in the expression of CycE in the wing imaginal disk when overexpressed. Unable to increase expression of Myc and ago in the wing imaginal disk when overexpressed; when associated with A-2305 and A-2328.
Loss of activity in Myc-mediated growth in the wing and eye, and unable to increase expression of Myc and ago in the wing imaginal disk when overexpressed; when associated with A-2024 and A-2305.
Loss of activity in Myc-mediated growth in the wing and eye, and unable to increase expression of Myc and ago in the wing imaginal disk when overexpressed; when associated with A-2024 and A-2328.
Ubiquitin carboxyl-terminal hydrolase puf
In strain: NVIII-2, NVIII-5 and NVIII-m15.
26S proteasome non-ATPase regulatory subunit RPN1 C-terminal
RNA 3'-terminal phosphate cyclase insert
2-fold reduction in zinc transport activity in yeast assay; when in association with A-584 and A-588.
2-fold reduction in zinc transport activity in yeast assay; when in association with A-584 and A-591.
2-fold reduction in zinc transport activity in yeast assay; when in association with A-588 and A-591.
2-fold reduction zinc transport activity in yeast assay.
4-fold reduction in zinc transport activity in yeast assay.
Severely reduced zinc transport activity in yeast assay.
Reduction in levels of cleavage; when associated with Asp-92.
Reduction in levels of cleavage; when associated with Asp-93.
Reduction in levels of cleavage; when associated with Trp-79.
Reduction in levels of cleavage; when associated with Trp-80.
Serine protease HTRA2, mitochondrial, long
Serine protease HTRA2, mitochondrial, short
Significant reduction of th/Diap1 binding.
ATP-dependent (S)-NAD(P)H-hydrate dehydratase
Probable ATP-dependent RNA helicase pitchoune
In allele shd-Z383; failure of head involution. Defects in dorsal closure and aberrant gut looping.
Nucleosome-remodeling factor subunit NURF301
Required for function in nucleosome sliding
Abolishes phosphatase activity. Loss of bsk/JNK binding. Reduced nuclear localization.
Dual specificity protein phosphatase MPK-4
In allele lgs-17E; segment polarity phenotype.
In strain: CAM-2, CAM-3, CAM-8, CAM-12, CAM-41, CAM-44, CAM-48 and Berkeley.
In strain: CAM-8, CAM-44, CAM-48 and Berkeley.
Enhancer of yellow 2b transcription factor
Ubiquitin carboxyl-terminal hydrolase 47
Mediator of RNA polymerase II transcription subunit 11
Translocon-associated protein subunit delta
Membrane insertase YidC/Oxa/ALB C-terminal
Glycosyltransferase-like domain-containing protein 1-like
4-hydroxybenzoate polyprenyltransferase, mitochondrial
Mitochondrial import inner membrane translocase subunit TIM50-B
Neutral/alkaline non-lysosomal ceramidase C-terminal
Neutral/alkaline non-lysosomal ceramidase N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Eukaryotic glycogen debranching enzyme N-terminal
Glycogen debranching enzyme glucanotransferase
Protein-L-isoaspartate(D-aspartate) O-methyltransferase
PiggyBac transposable element-derived protein
PiggyBac transposable element-derived protein 4 C-terminal zinc-ribbon
RZZ complex subunit KNTC1/ROD C-terminal
Decrease in apparent molecular weight of 16 kDa subunit.
Decrease in apparent molecular weight of 55 kDa subunit. Decrease in apparent molecular weight of 55 kDa subunit equivalent to the sum of decreases observed with S-174; D-133 and D-331; when associated with D-331 and D-531.
Decrease in apparent molecular weight of the 55 kDa subunit. Decrease in apparent molecular weight of 55 kDa subunit equivalent to the sum of individual decreases observed with S-174; D-331 and D-531; when associated with S-174 and D-331.
Decrease in apparent molecular weight of the 55 kDa subunit. Decrease in apparent molecular weight of 55 kDa subunit equivalent to the sum of individual decreases observed with S-174; D-331 and D-531; when associated with S-174 and D-531.
No change in apparent molecular weight of the 55 kDa subunit.
Helical; Note=After insertion into the membrane
Tetratricopeptide repeat protein 7 N-terminal
tRNA N(3)-methylcytidine methyltransferase Mettl2
Phosphatidic acid phosphatase type 2/haloperoxidase
In isoform A, isoform B, isoform H and isoform I.
Transmembrane protein TMEM132 C-terminal
Transmembrane protein TMEM132 N-terminal
Ecdysone-induced protein 75B, isoforms C/D
General transcription factor IIF subunit 1
Induces the formation of microtubule-rich protrusions. Abolishes repression of Yki. Causes an isoform A-like cellular phenotype with development of filopodia-like structures.
Nuclear pore complex protein Nup160 homolog
Phosphoadenosine phosphosulphate reductase
Abolished binding to nucleic acid activator, leading to impaired antiviral immunity; when associated with E-256.
Abolished binding to nucleic acid activator, leading to impaired antiviral immunity; when associated with E-267 or E-271.
Abolished nucleotidyltransferase activity.
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
In follicle epithelial cells, apical accumulation of the basal membrane protein vkg as apical extracellular aggregates. Crag levels decrease and Crag no longer accumulates at the plasma membrane, instead it has a diffuse cytoplasmic distribution. No direct effect on maintenance of apical-basal polarity in follicle cells.
In follicle epithelial cells, decreases extracellular PtdInsP2 on apical and lateral sides of the plasma membrane resulting in the abnormal apical accumulation of basal membrane proteins such as vkg. As a consequence the follicle cells display multiple layers or gaps in the epithelium.
RNA-polymerase II-associated protein 3-like C-terminal
Abolished E3 ubiquitin-protein ligase activity and ability to ubiquitinate Syb. Impaired ability to promote transcytosis of wg.
Abolishes binding to human SELENOF/SEP15.
Destabilizes protein structure and targets it for degradation.
UDP-glucose:glycoprotein glucosyltransferase
Nuclear condensin complex subunit 3 C-terminal
Decreases mRNA deadelynation and decay; when associated with A-491.
Decreases mRNA deadelynation and decay; when associated with A-493.
Protein phosphatase PP2A 55 kDa regulatory subunit
Eukaryotic translation initiation factor 2A
Translation initiation factor beta propellor-like
In strain: Zim63H-16C, Zim63H-34C and Zim63I-7C.
cGMP-dependent protein kinase interacting
Disrupts mitochondrial function and results in enlarged mitochondria. Neurons present vacuolar lesions leading to neurodegeneration in the central brain. Results in behavioral defects and shorten lifespan.
NADH dehydrogenase (ubiquinone) 23 kDa subunit
Eukaryotic translation initiation factor 3 subunit L
7 X approximate tandem repeats, Gly/Ser-rich
Protein lethal(3)malignant blood neoplasm 1
In strain: NC336, NC358, NC361, NC362 and NC375.
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
dolichyl-phosphate-mannose--protein mannosyltransferase
In strain: Raleigh Inbred 6, Raleigh Inbred 9, Raleigh Inbred 11 and Raleigh Inbred 33.
In strain: Raleigh Inbred 6, Raleigh Inbred 9, Raleigh Inbred 11, Raleigh Inbred 27 and Raleigh Inbred 33.
In dsf1; males and females are sterile due to abnormal courtship behaviors and defects in their sex-specific nervous system. Females display active resistance and rejection behaviors during courtship and copulation. Synapses are also absent on the circumferential muscles of the uterus which likely results in the observed egg-laying defect in which the mature eggs reach the uterus but females are unable to lay them. Males actively court both females and males, and during the final step of courtship display defects in abdominal curling which is required to make genital-genital contact with females. The observed slow abdominal bends during mating is likely due, at least in part, to abnormal innervation of the ventral longitudinal muscles of abdominal segment 5 (A5).
In dsf7, greatly decreased DNA binding of fragment 1-102.
Reduced DNA binding and weakly represses DNA transcription.
Repressive Function 2 (RF2), important for transcriptional repression
Putative phospholipase B-like lamina ancestor
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase
G patch domain-containing protein 1 homolog
Cleavage (when cotranslationally processed)
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Loss of DNA-binding. Does not affect function in vivo; when associated with A-158 and A-166.
Loss of DNA-binding. Does not affect function in vivo; when associated with A-158 and A-185.
Loss of DNA-binding. Does not affect function in vivo; when associated with A-166 and A-185.
In strain: fs(3)Neo61, Wpg1, Wpg10, Wpg16, Wpg2, Wpg3, Zim10, Zim18, Zim32 and Zim35.
Threonylcarbamoyladenosine tRNA methylthiotransferase
Beta-hairpin required for oligomerization
In Z2217; Impairs cytokinesis. Prevents binding to PI(4)P and PI(5)P.
Prevents binding to PI(4)P and abolishes sau localization to the Golgi membranes and cleavage furrow; when associated with A-167.
Prevents binding to PI(4)P and abolishes sau localization to the Golgi membranes and cleavage furrow; when associated with L-170.
Cyclic nucleotide-gated cation channel subunit A
Acetylcholine receptor subunit beta-like 1
Cullin-associated NEDD8-dissociated protein 1
TATA-binding protein interacting (TIP20)
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Histone-lysine N-methyltransferase eggless
Extracellular serine/threonine protein CG31145
U5 small nuclear ribonucleoprotein 200 kDa helicase
Abolishes histone acetyltransferase activity.
In strain: Africa-0, Africa-3, Africa-4, Congo 194 and Mof.591A.s.
In strain: Congo 159, Congo 194 and Congo 216.
In strain: Congo 8, Congo 13, Congo 194 and Mof.820A.s.
Nearly abolishes histone acetyltransferase activity.
Strongly reduces histone acetyltransferase activity. Males fail to metamorphose and hatch.
Does not affect interaction with ric8a; when associated with A-120 and A-167.
Does not affect interaction with ric8a; when associated with A-84 and A-120.
Does not affect interaction with ric8a; when associated with A-84 and A-167.
In strain: Oregon-R, NVIII-1, NVIII-18, NVIII-2, NVIII-22, NVIII-24, NVIII-28, NVIII-41, NVIII-42, NVIII-46, NVIII-5, NVIII-9, NVIII-m11, NVIII-m12, NVIII-m13, NVIII-m15 and NVIII-m19.
26S proteasome non-ATPase regulatory subunit 4
Interchain (between non-catalytic and catalytic chains)
Serine proteinase stubble catalytic chain
Serine proteinase stubble non-catalytic chain
In allele mod(mdg4)351; embryonic lethal; when associated with N-33.
In allele mod(mdg4)351; embryonic lethal; when associated with S-92.
5-glutamyl glycerylphosphorylethanolamine
Vacuolar protein sorting-associated protein 28 homolog
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
In strain: ZBMEL131, ZBMEL157, ZBMEL186 and ZBMEL191.
In strain: ZBMEL131, ZBMEL186, ZBMEL229, ZBMEL377 and ZBMEL398.
Probable H/ACA ribonucleoprotein complex subunit 1
In strain: Nv2001_f0696, NVIII-46 and NVIII-24.
Glucosamine/galactosamine-6-phosphate isomerase
Impairs microtubule polymerization, decreases microtubule lattice localization.
Impairs microtubule polymerization. Disrupts tubulin binding; when associated with E-21.
Impairs microtubule polymerization. Disrupts tubulin binding; when associated with E-292.
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Binding to basic helix-loop-helix domain
Reduces nuclear aCCumulation in ovary and ovarian somatic cells. Affects transposable element silencing. Causes female sterility.
Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein
Mitochondrial inner membrane protease subunit 2
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Dynein axonemal assembly factor 1 homolog
Probable cytochrome P450 12a5, mitochondrial
In strain: isofemale line 31, isofemale line 32, isofemale line 68, La14, La14, La16, La35, M01, M06, M09, M12, M26, M47, Ma5, Ma7, Ma13, Ma18, Ma20, Ma21, Ma45, Ma48, Ma50, Ma52, Ma67, Mo2b, Mo15b, Mo34a, Mo36a, Mo37a, Mo47a, Mo52b, Mo58b, Mo80b, NFS 5.1, NFS 5.2, NFS 5.4, NFS 6.2, NFS 6.3, NFS 6.4, SFS 1.1, SFS 1.3, SFS 1.4, SFS 2.2, SFS 3.1, SFS 3.3, WS1, WS6, WS9, WS12, WS16, WS26, WS47, WS56, Zim2, Zim26, Zim29, Zim30, Zim32, Zim37, Zim42 and Zim56.
In strain: isofemale line 32, La1, La3, La4, La5, La14, La15, La16, La21, La25, La34, La35, M18, Ma5, Ma8, Ma13, Ma18, Ma20, Ma21, Ma45, Ma48, Ma52, Ma67, Mo1b, Mo52b, Mo80b, NFS 6.1, SFS 1.2, WS6, WS19, Zim26, Zim29, Zim30 and Zim56.
In bratfs3; induces production of tumor-like neoplasms in the larval brain. Disrupts interaction with nanos and pum.
In bratts1; induces production of tumor-like neoplasms in the larval brain. Disrupts interaction with nanos and pum.
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase P
Interaction with galactose moiety of substrate glycoprotein
Cysteine/serine-rich nuclear protein N-terminal
Biogenesis of lysosome-related organelles complex 1 subunit 2
Glutaredoxin domain-containing cysteine-rich protein CG12206
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
In strain: MW25, MW38, MW56, MW63, MW9, NC304, NC357 and NC361.
In strain: MW6, MW27, NC301, NC304 and NC397.
In z5864; Induces 4th chromosome non-disjunction.
26S proteasome non-ATPase regulatory subunit 6
Proton acceptor; for glutaminase activity
PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Transcription initiation factor TFIID subunit 4
Nucleolar MIF4G domain-containing protein 1 homolog
Abolishes interaction with pre-miRNA (pre let 7) in the presence of Dcr-1.
Enables simultaneous binding of both DRBM 1 and 2 domains to dsRNA
Important for homodimerization and interaction with Dcr-1
Loss of activity, abolishes interaction with Dcr-1 and therefore does not enhance pre-miRNA processing by the dicer.
Necessary and sufficient for enhancing processing of pre-miRNAs by Dcr-1
Necessary for enhancing pre-miRNA processing by Dcr-1
Necessary for promoting preferential binding of Dcr-2 to the less stably base paired ends of siRNAs
Required for binding to Dcr-2 and to fully enhance Dcr-2 mediated cleavage of 3' overhanging termini (3'ovr) and blunt termini (BLT) dsRNAs. However, this region is dispensable for binding the dsRNA substrates
Mitochondrial import inner membrane translocase subunit TIM50-C
Possible lysine-specific histone demethylase 1
9 X 2 AA approximate tandem repeats of R-G
Probable small nuclear ribonucleoprotein Sm D1
Potassium voltage-gated channel protein Shal
Eukaryotic translation elongation factor 2
Probable cytochrome P450 12d1 distal, mitochondrial
Probable rRNA-processing protein EBP2 homolog
Cilia- and flagella-associated protein 298
In PJ42 mutant; loss of exu function in female.
tRNA-splicing endonuclease subunit Sen15
Significant decrease in TORC1 activity in adult ovaries indicated by reduced phosphorylation of S6K/p70S6K and the accumulation of autolysosomes. Female germline clones are smaller compared to wild-type cells. In contrast, somatic tissues do not display a significant decrease in TORC1 activity and there is only a negligible decrease in cell size. RNAi-mediated knockdown of Nprl1 or Nprl3 rescues the ovarian defects in mutants, but not the accumulation of lysosomes.
Putative inactive tyrosine-protein kinase Wsck
Breast cancer type 2 susceptibility protein homolog
Activity-regulated cytoskeleton associated protein 1
Ca(2+)/calmodulin-responsive adenylate cyclase
No effect on binding to wash and no effect on tail hemocyte developmental migration from the tail.
Reduces binding to wash. Reduces the number of hemocytes migrating anteriorly from the tail during embryogenesis.
DEAD-box ATP-dependent DNA helicase Fancm
Loss of catalytic activity. Abolishes formation of linear polyubiquitin chains, slight reduction in longevity and upon heat shock, adults display reduced induction of Hsp70 and thus a reduction in heat stress tolerance. No obvious effect on adult phenotype and no reduction in immunity to E.coli infection; when associated with S-2690.
Loss of catalytic activity. Abolishes formation of linear polyubiquitin chains, slight reduction in longevity and upon heat shock, adults display reduced induction of Hsp70 and thus a reduction in heat stress tolerance. No obvious effect on adult phenotype and no reduction in immunity to E.coli infection; when associated with S-2693.
Necessary for linear polyubiquitination and sufficent for inducing DptA in the intestine
Reduces formation of linear polyubiquitin chains, slight reduction in longevity and upon heat shock adults display reduced induction of Hsp70 and thus a reduction in heat stress tolerance. No obvious effect on adult phenotype and no reduction in immunity to E.coli infection.
Reduces formation of linear polyubiquitin chains.
Reduces formation of linear ubiquitin chains.
Increase in late endosome size. Loss of binding to various phosphoinositides, but no loss of binding to phosphatidylinositol 3-phosphate (PtdIns3P). Localization to the cell cortex and endosomes is not affected.
No localization to the endosomes. Present at the plasma membrane and in the cytosol. Loss of binding to PtdIns3P.
Pleckstrin homology domain-containing family F member 1 homolog
Phosphatidate cytidylyltransferase, mitochondrial
Phosphorylase b kinase regulatory subunit alpha/beta C-terminal
Probable phosphorylase b kinase regulatory subunit beta
In ter94-26-8; arrests early in oogenesis.
Transitional endoplasmic reticulum ATPase TER94
Interferon regulatory factor 2-binding protein 1 & 2 zinc finger
Large ribosomal subunit protein uL30 N-terminal eukaryotes
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Probable mitochondrial import inner membrane translocase subunit Tim17 3
Cysteine-rich DPF motif domain-containing protein 1
Pentacotripeptide-repeat region of PRORP
Stellate protein CG33236/CG33240/CG33244/CG33245
Mitochondrial import inner membrane translocase subunit TIM50-A
7 X 5 AA approximate repeats of P-V-S-V-P
In strain: DPF; induces a high-diapause phenotype.
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11
Male sterility. Spermatocytes display various defects during early meiotic stages, post-meiotic stages and late spermatogenesis. Defects in early meiotic stages result in karyokinesis and cytokinesis abnormailities and a failure to complete meiosis I. Differentiation arrest prior to spermatid individualization results in seminal vesicles lacking mature sperm.
Impaired cell cycle arrest in response to the DNA synthesis inhibitor hydroxyurea (HU).
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
N-end rule aminoacyl transferase C-terminal
Mitochondrial import receptor subunit TOM40 homolog 1
In strain: MelZim1, MelZim3, MelZim4, MelZim5, MelZim6 and MelZim7.
In strain: MelZim1, MelZim4, MelZim5 and MelZim6.
In strain: MelZim1, MelZim5 and MelZim6.
4 X 8 AA approximate tandem repeats of T-S-A-S-A-T-T-T
Probable cGMP 3',5'-cyclic phosphodiesterase subunit delta
tRNA (guanosine(34)-2'-O)-methyltransferase
Nitrilase and fragile histidine triad fusion protein NitFhit
Decreased binding to piwi and unable to rescue fertility and transposon activation defects in mutants. Abolishes binding to piwi; when associated with A-328.
Significant decrease in binding to unmethylated piwi.
Tudor and KH domain-containing protein homolog
Unable to rescue fertility and transposon activation defects in mutants. Abolishes binding to piwi; when associated with R-348.
Armadillo repeat-containing protein 6 homolog
In both embryo and larva, results in irregularly shaped salivary glands with bulges of variable sizes, leading to greater distances between neighboring nuclei.
Mitochondrial import inner membrane translocase subunit Tim10
Non-structural maintenance of chromosomes element 1 RING C4HC3-type
Non-structural maintenance of chromosomes element 1 homolog
Loss of myristoylation. Overexpression in perineurial glia, leads to decreased ethanol sensitivity upon initial exposure and has no effect on ethanol tolerance following repeated exposure in contrast to overexpression of the wild-type form, possibly by delocalizing the protein from the membrane.
Loss of phosphorylation by PKC. Overexpression in perineurial glia, results in reduced locomotor sensitization when first exposed to ethanol and ethanol tolerance following repeated exposure; when associated with A-135 and A-137.
Overexpression in perineurial glia, leads to decreased ethanol sensitivity upon initial exposure and has no effect on ethanol tolerance following repeated exposure in contrast to overexpression of the wild-type form, possibly by delocalizing the protein from the membrane; when associated with D-132 and D-135.
Overexpression in perineurial glia, leads to decreased ethanol sensitivity upon initial exposure and has no effect on ethanol tolerance following repeated exposure in contrast to overexpression of the wild-type form, possibly by delocalizing the protein from the membrane; when associated with D-132 and D-137.
Overexpression in perineurial glia, leads to decreased ethanol sensitivity upon initial exposure and has no effect on ethanol tolerance following repeated exposure in contrast to overexpression of the wild-type form, possibly by delocalizing the protein from the membrane; when associated with D-135 and D-137.
Partial loss of phosphorylation by PKC; when associated with A-137. Overexpression in perineurial glia, results in reduced locomotor sensitization when first exposed to ethanol and ethanol tolerance following repeated exposure; when associated with A-132 and A-137.
Partial loss of phosphorylation by PKC; when associated with A-13A. Overexpression in perineurial glia, results in reduced locomotor sensitization when first exposed to ethanol and ethanol tolerance following repeated exposure; when associated with A-132 and A-135.
In strain: 399A, 774A, 852A, 859A, Congo13, Congo194 and Congo346.
In strain: 5, 7, 399A, 591A, 799A, 852A, 859A, Amherst, Congo13, Congo194, Congo216 and Congo346.
Putative epidermal cell surface receptor
In strain: Oregon-R, Z145, Z266, Z346 and Z398.
KRR1 small subunit processome component homolog
Probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase
Does not affect catalytic activity but decreased conformational stability in vitro; when associated with A-113.
Does not affect catalytic activity but decreased conformational stability in vitro; when associated with A-136.
Does not lead to transitional endoplasmic reticulum sites disassembly. Partially rescue transitional endoplasmic reticulum site disassembly induced by amino-acid starvation.
Does not lead to transitional endoplasmic reticulum sites disassembly; when associated with A-190.
Does not lead to transitional endoplasmic reticulum sites disassembly; when associated with F-192.
Mediator of RNA polymerase II transcription subunit 8
Guanine nucleotide exchange factor subunit Rich
In ORE119; defective in embryonic axon guidance.
In ORE120; defective in embryonic axon guidance.
Longitudinals lacking protein, isoform G
Longitudinals lacking protein, isoforms A/B/D/L
Longitudinals lacking protein, isoforms F/I/K/T
Longitudinals lacking protein, isoforms H/M/V
Longitudinals lacking protein, isoforms J/P/Q/S/Z
Longitudinals lacking protein, isoforms N/O/W/X/Y
In strain: Oregon-R, ZBMEL84, ZBMEL95, ZBMEL131, ZBMEL157, ZBMEL186, ZBMEL191 and ZBMEL229.
Alcohol dehydrogenase-related 31 kDa protein
Probable phosphorylase b kinase regulatory subunit alpha
Required for interaction with skpA and Cul1, but not with PI31
Probable G-protein coupled receptor Mth-like 1
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial
Molybdopterin synthase sulfur carrier subunit
In ago-3; increased cell proliferation and decrease in ability to bind CycE.
Abrogates enhancement of gypsy chromatin insulator activity.
Abrogates ubiquitin-protein E3 ligase activity.
Zinc finger TRAF-type-containing protein 1 homolog
Loss of 'K-48'- and 'K-63'-linked polyubiquitin chain hydrolysis; when associated with S-181.
Loss of H2B deubiquitination. Loss of 'K-48'- and 'K-63'-linked polyubiquitin chain hydrolysis; when associated with N-369.
Ubiquitin carboxyl-terminal hydrolase 36
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial
In strain: IS2, IS3, IS4, IS5, IS25 and QD18.
Ubiquitin carboxyl-terminal hydrolase 16/45
DNA polymerase interacting tetratricopeptide repeat-containing, protein of 47 kDa
Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding
Ribosome biogenesis protein BRX1 homolog
Nuclear receptor binding SET domain protein
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Phosphatidylserine amidated glycine; alternate
Transforming acidic coiled-coil-containing protein C-terminal
non-specific serine/threonine protein kinase
In isoform I, isoform H, isoform K and isoform L.
Does not affect subcellular location. Loss of catalytic activity.
Polypeptide N-acetylgalactosaminyltransferase 3
Putative polypeptide N-acetylgalactosaminyltransferase 9
Results in secretory granule defects including an angular and shard-like morphology.
Protein-lysine N-methyltransferase CG9154
Bifunctional arginine demethylase and lysyl-hydroxylase PSR
In strain: NapaValley5, NapaValley12, sonoma_015, sonoma_016, sonoma_023, sonoma_032, sonoma_034, sonoma_038, sonoma_040, sonoma_045, sonoma_048, sonoma_050, sonoma_061, sonoma_073, sonoma_081, sonoma_085, sonoma_094, sonoma_097 and sonoma_119.
In strain: nps_19, nps_21, nps_25, nps_26, nps_27, nps_30, nps_31, nps_33, nps_35, nps_42, nps_43, nps_45, nps_47, sonoma_002, sonoma_003, sonoma_004, sonoma_005, sonoma_006, sonoma_007, sonoma_008, sonoma_009, sonoma_014, sonoma_016, sonoma_017, sonoma_022, sonoma_024, sonoma_032, sonoma_033, sonoma_036, sonoma_038, sonoma_045, sonoma_051, sonoma_053, sonoma_054, sonoma_055, sonoma_059, sonoma_061, sonoma_064, sonoma_081, sonoma_086, sonoma_087, sonoma_094, sonoma_095, sonoma_097, sonoma_106, sonoma_107 and sonoma_119.
In strain: nps_6, nps_18, nps_34, sonoma_048 and sonoma_050.
In strain: sonoma_006, sonoma_022 and sonoma_040.
In strain: sonoma_008, sonoma_015, sonoma_016, sonoma_032, sonoma_034, sonoma_038, sonoma_040, sonoma_045, sonoma_048, sonoma_050, sonoma_061, sonoma_073, sonoma_081, sonoma_085, sonoma_094 and sonoma_097.
In strain: sonoma_009, sonoma_051, sonoma_053 and sonoma_054.
In strain: sonoma_010, sonoma_013, sonoma_019 and sonoma_117.
Eukaryotic translation initiation factor 3 subunit J
Probable small nuclear ribonucleoprotein G
Succinate dehydrogenase assembly factor 2-B, mitochondrial
Abolishes interaction with PCNA and subsequent degradation by the proteasome.
Increased interaction with Akt1 and some negative regulation of Atk1. Increased interaction with slbo but no effect on negative regulation of slbo-dependent border cell migration. No effect on interaction and negative regulation of stg-dependent cell divisions in the wing.
No effect on mitosis. Embryos display an early pause in the cell cycle similar to wild-type.
Partial loss of border cell migration when expressed in border cells.
Reduced interaction and inhibition of Akt1 resulting in increased Akt1-mediated growth and loss of carbohydrate clearance from the hemolymph. No effect on interaction with slbo and stg, and no effect on the negative regulation of slbo-dependent border cell migration and stg-dependent cell divisions in the wing.
Reduced interaction with Akt1 and reduced inhibition of Akt1-mediated growth. Reduced interaction with slbo and fails to block border cell migration. No effect on cell division in the posterior compartment of the wing.
Gain of interaction with ric8a which is as effective as interaction of Frq2 with ric8a.
Gain of interaction with ric8a which is less effective than interaction of Frq2 with ric8a.
In allele inaD-P215; slow recovery of light-induced responses and altered light sensitivity. Abolishes interaction with trp.
Inactivation-no-after-potential D protein
Nearly 2-fold increase in interaction with inaC.
Over 3-fold increase in interaction with inaC.
Slight reduction in interaction with inaC.
In shf2; induces defects in the hh pathway.
In shf919; induces defects in the hh pathway.
General transcription and DNA repair factor IIH helicase subunit XPB
Ovarian-specific serine/threonine-protein kinase Lok
Vacuolar protein sorting-associated protein 26
In eys(734); fails to form an interrhabdomeral space.
Abolishes formation of methionine-sulfoxide and subsequent depolymerization.
Phosphorylated adapter RNA export protein RNA-binding
Small ribosomal subunit protein mS23 conserved
Heterologous expression in salivary glands shows inhibition of calcium influx.
In allele DB25; defect in synaptic transmission and homozygous lethal.
In strain: XCPA4, XCPA7, XCPA25, XCPA51, XCPA77, XCPA93, XCPA102, XCPA105, XCPA122 and XCPA125.
Transmembrane protein 131-like N-terminal
Transmembrane protein 131-like conserved
Bridge-like lipid transfer protein family member 1 C-terminal
Eukaryotic peptide chain release factor subunit 1
G-protein coupled receptors family 2 profile 1
Histone-lysine N-methyltransferase Su(var)3-9
DNA-directed RNA polymerases I, II, and III subunit RPABC2
Loss of nuclear location. Location is mainly cytoplasmic or diffuse.
Required for endoplasmic reticulum-cell membrane contact sites location and binding to phosphatidylinositols
Mediator of RNA polymerase II transcription subunit 31
In strain: AF2, AF7, Au4, La3, La15, La37, La58, Ma21, Mo29b, Mo36a, Mo52B, Mo79b, NC-009, Ny3, Ny5 and TW11.
In strain: AF5, AF10, Au5, La3, La15, La105, Mo36a, Mo37a, Mo47a, Mo79b and TW10.
In strain: AF6, AF8, AF9, Au4, La31, La32, La60, La125, Ma6, Ma21, Ma57, TW1 and TW11.
Males have no visible phenotype and are fertile. However, mated females display a decrease in the number of oocytes released by their ovary and deposit fewer eggs on day 1 after the start of mating (ASM). No effect on the number of eggs laid by mated females on day 2 to 4 ASM. No effect on female receptibility to another mate and does not affect sperm resistance to displacement by rival ejaculates.
Necessary and sufficient for homodimerization
Sufficient for promoting ovulation when expressed in females
Abolishes RNA binding without altering the conformation of the domain.
Affects RNA binding without altering the conformation of the domain.
In strain: AF-F, F1-F, F1-1S, JA-F, LW8, MW18 and ZW20.
Armadillo repeat-containing protein gudu
Chromosomal serine/threonine-protein kinase JIL-1
rRNA N6-adenosine-methyltransferase Mettl5
Temperature-sensitive mutation; disrupts production of the steroid hormone ecdysone, causes developmental and reproductive defects.
Structure-specific endonuclease subunit SLX4
Enoyl-[acyl-carrier-protein] reductase, mitochondrial
Ribose-phosphate pyrophosphokinase N-terminal
Transcription initiation factor TFIID subunit 6
Kinase-dead. No effect on interaction with drpr.
Concentrative nucleoside transporter C-terminal
Concentrative nucleoside transporter N-terminal
MORN repeat-containing protein 4 homolog
Cytochrome c oxidase assembly factor 3, mitochondrial
Protein transport protein Sec61 gamma-1 subunit
S-adenosylmethionine mitochondrial carrier protein homolog
Abolishes interaction with Tnks but does not affect interaction with PSMD5 and PSMD9; when associated with A-49.
Abolishes interaction with Tnks but does not affect interaction with PSMD5 and PSMD9; when associated with A-54.
Abolishes interaction with Tnks, PSMD5 and PSMD9.
Abolishes interaction with Tnks, PSMD5 and PSMD9. Reduces 26S proteasome activation.
Fails to rescue null mutant phenotype; when associated with E-103.
Fails to rescue null mutant phenotype; when associated with E-96.
Homologous recombination repair is reduced by 70% resulting in mutants displaying extreme sensitivity to various DNA damaging agents, except for camptothecin.
Necessary for function, possibly resulting from its inability to interact with PolD2
Rescues bristle and female fertility defects in mutants.
Unable to rescue bristle and female fertility defects in mutants.
Major facilitator superfamily associated
MAP kinase-activating death domain protein
Important for DNA bending; intercalates between base pairs of target DNA
No effect on double-stranded DNA cleavage. Strong decrease in ATPase activity and strand passage activity.
Mediator of RNA polymerase II transcription subunit 18
Lethal; survival is reduced to five days. Abolishes assembly of the siRNA-directed RISC loading complex (siRLC) and, as a consequence, abolishes formation of the RNA-induced silencing complex (siRISC). No effect on the formation of the R2-D2-Initiator complex (RDI) or dsRNA-processing activity to generate siRNAs.
Lethal; survival is reduced to five days. Severely decreases dsRNA-induced RNAi silencing resulting in decreased production of endogenous siRNAs.
Transcription initiation factor TFIID subunit 11
RNA 2-O ribose methyltransferase substrate binding
Little effect on binding to liposomes, phosphatidylinositol 4,5-bisphosphate and inositol 1,4,5-trisphosphate.
Loss of binding to liposomes containing phosphoinositides. In contrast to wild-type protein whose expression largely rescues mutant phenotypes, expression in mutant neurons only partially rescues the increase in synapse mobility and the abherent accumulation of large cisternal or endosomal-like structures in pre-synaptic terminals observed in mutants. In addition, the number of mutants displaying defective motor coordination, defective flight, hyperactivity, increased temperature sensitivity and seziures is increased compared to mutants expressing wild-type protein.
Reduced binding to liposomes under low phosphatidylinositol 4,5-bisphosphate (PIP2) concentrations. Reduced binding to inositol 1,4,5-trisphosphate (IP3). In contrast to wild-type, expression only partially rescues the accumulation of sub-boutonic foci.
SET domain-containing protein SmydA-8, isoform A
SET domain-containing protein SmydA-8, isoform B
Nucleolus and neural progenitor protein-like N-terminal
Strongly reduces ability to activate mth.
Abolishes interaction with me31B and impairs translational repression and induction of mRNA decay.
Important for promoting translational repression
In C; impairs interaction with eIF4EHP but has no effect on translational repression or induction of mRNA decay; when associated with A-58 and A-60.
In C; impairs interaction with eIF4EHP but has no effect on translational repression or induction of mRNA decay; when associated with A-58 and a-65.
In C; impairs interaction with eIF4EHP but has no effect on translational repression or induction of mRNA decay; when associated with A-60 and a-65.
In FF; abolishes interaction with me31B; when associated with A-361.
In FF; abolishes interaction with me31B; when associated with A-367.
In GYF; impairs interaction with Patr-1 but has no effect on translational repression or induction of mRNA decay, and does not affect interaction with me31B or Not1; when associated with A-571, A-582 and A-590.
In GYF; impairs interaction with Patr-1 but has no effect on translational repression or induction of mRNA decay, and does not affect interaction with me31B or Not1; when associated with A-571, A-582,and A-596.
In GYF; impairs interaction with Patr-1 but has no effect on translational repression or induction of mRNA decay, and does not affect interaction with me31B or Not1; when associated with A-571, A-590 and A-596.
In GYF; impairs interaction with Patr-1 but has no effect on translational repression or induction of mRNA decay, and does not affect interaction with me31B or Not1; when associated with A-582, A-590 and A-596.
20-fold increase in levels of mitotic recombination, very limited 3'-5' exonuclease activity.
Completely lacks exonuclease activity, when associated with A-162.
Completely lacks exonuclease activity, when associated with A-164.
Intermembrane lipid transfer protein Vps13
Solute carrier family 3 member 2 N-terminal
Cleaves the 3' (bottom) strand but not the 5' (top) strand of pre-miRNA.
Cleaves the 3' (bottom) strand but not the 5' (top) strand of pre-miRNA. Abolishes cleavage of pre-miRNA; when associated with A-1908.
Cleaves the 5' (top) strand but not the 3' (bottom) strand of pre-miRNA.
Cleaves the 5' (top) strand but not the 3' (bottom) strand of pre-miRNA. Abolishes cleavage of pre-miRNA; when associated with A-2139.
Dispensable for activity and substrate recognition
Essential for miRNA substrate recognition
Essential for production of mature miRNAs from pre-miRNAs. Also important for proper formation of the siRISC complex but is dispensable for biogenesis of siRNAs
Important for interaction with loqs isoform PB (loqs-PB)
Necessary for processing certain pre-miRNas, such as pre-let 7 and pre-bantam
No effect on processing of the pre-miRNas, pre-let 7 and pre-bantam.
AB hydrolase-1 domain-containing protein
Phosphoribosylformylglycinamidine synthase
Mitochondrial import receptor subunit TOM40 homolog 2
Required for activity. Inhibits negative regulation of Rho1 but has no effect on the positive regulation of Rac1.
Conserved oligomeric Golgi complex subunit 6
May act as a substrate filter by repelling compounds with a negatively charged alpha-carboxylate
In 3B20; probable loss of function. The lumen of separate tracheal branches fails to fuse during anastomosis and Syx1A does not localize to the fusion point.
Shows resistance to picrotoxin-induced activity inhibition.
Raf homolog serine/threonine-protein kinase Raf
Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial
Involved in binding clathrin light chain
DNA-directed RNA polymerase I subunit RPA1
Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial
26S proteasome non-ATPase regulatory subunit 9
Highly reduced ectopic eye induction and diminishes degree of ommatidial restoration in eyeless phenotype rescue assay.
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
No ventral furrow formation during gastrulation and reduced binding to CycA; when associated with A-86.
No ventral furrow formation during gastrulation and reduced binding to CycA; when associated with A-88.
Centrosomal localization and interaction with microtubules
Centrosomal targeting M domain involved in interaction with ZIPIC
Centrosome-associated zinc finger protein Cp190
Asparagine synthetase domain-containing protein CG17486
Transcriptional repressor p66 coiled-coil MBD2-interaction
Solute-binding protein family 3/N-terminal
Defects in sensory bristle formation and wing shape, and oogenesis. Non-functional; when associated with A-10.
Defects in sensory bristle formation and wing shape, and oogenesis; when associated with Y-170.
Defects in sensory bristle formation and wing shape, and oogenesis; when associated with Y-173.
Non-functional; when associated with A-89.
Elongation of very long chain fatty acids protein 7
Stress-activated map kinase-interacting protein 1
Very long-chain-fatty-acid--CoA ligase bubblegum
Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial
Alpha-D-phosphohexomutase alpha/beta/alpha
ATP synthase subunit beta, mitochondrial
Nascent polypeptide-associated complex subunit alpha-like UBA
Non-structural maintenance of chromosome element 4 C-terminal
VPS35 endosomal protein sorting factor-like
Underreplication is suppressed in larval salivary glands.
Mannosyl-oligosaccharide alpha-1,2-mannosidase IA
Vacuolar protein sorting-associated protein 54
Biopterin-dependent aromatic amino acid hydroxylase family profile
In ash1-10; induces lethality between prepupal and late pupal stages.
In ash1-21; induces lethality between prepupal and late pupal stages.
28S rRNA (cytosine-C(5))-methyltransferase
In Muta; reduced iav expression in the cilia but is not required for lav or nompC localization in the cilia.
In Mutb; reduced iav expression in the cilia but is not required for lav or nompC localization in the cilia. Decrease in extracellular sound-evoked potentials. Sounds-evoked potentials, and localization of ktub, iav and nompC is partially restored in a ktub and INPP5E double mutant background.
Formation of tetramers, dimers and monomers.
Mainly tetrameric with formation of some monomers. Mainly dimeric; when associated with D-726.
Mainly tetrameric. Mainly dimeric; when associated with R-775.
Spindle defects and greatly reduced phosphorylation by Wee1 in vitro; when associated with F-152 and F-207.
Spindle defects and greatly reduced phosphorylation by Wee1 in vitro; when associated with F-23 and F-152.
Spindle defects and greatly reduced phosphorylation by Wee1 in vitro; when associated with F-23 and F-207.
Partially rescues muscle function and structure defects in the null mutant. Fails to interact with alpha-PS2/beta-PS.
Does not affect ion and sulfide binding.
Does not affect ion and sulfide binding. Results in a partial increase in mitochondrial DNA copy number.
In vitro, loss of hexamer formation. Loss of mitochondrial transcription. In vivo, results in significant decrease in complex IV activity, increase in apoptosis and a decrease in cell proliferation.
In vitro, loss of mitochondrial transcription. In vivo, significant decrease in complex IV activity, increase in apoptosis and a decrease in cell proliferation. In vivo, results in significant decrease in complex IV activity, increase in apoptosis and a decrease in cell proliferation.
In vitro, no effect on mitochondrial transcription. In vivo, moderate decrease in mtDNA levels in the third instar larval stage and slight decrease in longevity in the adult.
Loss of hexamer formation. Loss of mitochondrial transcription.
Loss of ion and sulfide binding and increased protein instability, retains DNA binding; when associated with A-102.
Loss of ion and sulfide binding and increased protein instability, retains DNA binding; when associated with A-105.
Loss of ion and sulfide binding, increased protein instability, partial increase in mitochondrial DNA copy number, retains DNA binding; when associated with A-68.
Loss of ion and sulfide binding, increased protein instability, retains DNA binding, partial increase in mitochondrial DNA copy number; when associated with A-71.
Loss of ion and sulfide binding; when associated with A-245.
Loss of ion and sulfide binding; when associated with A-248.
Modest reduction in mitochondrial DNA copy number.
No effect on mitochondrial transcription.
No increase in mitochondrial DNA copy number.
Partial increase in mitochondrial DNA copy number.
Nonsense-mediated mRNA decay factor SMG8
Extracellular serine/threonine protein kinase four-jointed
Affects phosphorylation and localization to centromeres.
Does not stably associate with centromeres during mitosis.
In mei-S332-10; induces missegregation of chromatids during meiosis.
In mei-S332-2; induces missegregation of chromatids during meiosis.
In mei-S332-3; induces missegregation of chromatids during meiosis.
In mei-S332-4; induces missegregation of chromatids during meiosis; when associated with H-.
In mei-S332-4; induces missegregation of chromatids during meiosis; when associated with M-112.
In mei-S332-5; induces missegregation of chromatids during meiosis.
In mei-S332-6; induces missegregation of chromatids during meiosis.
In mei-S332-8; induces missegregation of chromatids during meiosis.
In mei-S332-9; induces missegregation of chromatids during meiosis.
U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase
Death-associated inhibitor of apoptosis 1
DNA-directed RNA polymerase II subunit RPB2
DNA-directed RNA polymerase subunit 2 hybrid-binding
cAMP-dependent protein kinase type II regulatory subunit
3-beta hydroxysteroid dehydrogenase/isomerase
Elongation of very long chain fatty acids protein F
When in a heterodimer with Chrac-16, reduces Acf binding but does not affect DNA binding or Acf nucleosome sliding activity.
When in a heterodimer with Chrac-16, reduces DNA binding and is less able to stimulate Acf nucleosome sliding activity.
Phosphatidate cytidylyltransferase, photoreceptor-specific
60 kDa heat shock protein homolog 1, mitochondrial
N6-adenosine-methyltransferase non-catalytic subunit
Probable ATP-dependent RNA helicase kurz
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Ubiquitin-like modifier-activating enzyme Atg7 N-terminal
ATPase H(+)-transporting accessory protein 2
ATPase H(+)-transporting accessory protein 2 C-terminal fragment
ATPase H(+)-transporting accessory protein 2 N-terminal fragment
Lethal in the late larval stage with few adult escapers showing poor mobility, decreased or absent climbing capabilities, blistered wings, reduced head size and death within 3-4 days after eclosion. Impairs localization to the endoplasmic reticulum, enhances cleavage and protein stability.
Prevents cleavage; when associated with A-248.
Prevents cleavage; when associated with A-251.
Reduces protein stability and increases N-glycosylation levels of proteins which targets the misfolded protein to degradation. Impairs autophagy and mTOR signaling. Reduces eclosion rate with few adult escapers showing poor mobility, decreased or absent climbing capabilities, blistered winds and reduced size and death within 3-4 days. In the brain, results in neural development defects in the optic lobe. In the fat body, increases lipid droplets size and total triglycerides.
Survive till late pupal stage. Impairs localization to the endoplasmic reticulum and autophagy degradation. In the fat body, increases lipid droplets size and total triglycerides.
Cysteine and histidine-rich domain-containing protein morgana
Early larval lethal. Homozygous neurons (generated by mosaic analysis) display decreased elongation/retraction rate of terminal branches, resulting in small dendritic arbors regardless of pupal body size and/or nutritional input. Also in both fed and starved pupae, dendritic segment length is decreased without simplifying the branching pattern.
In allele Smn-73Ao; homozygous lethal at late larval stages and abolishes homodimerization.
In allele Smn-B; homozygous lethal at late larval stages and abolishes homodimerization.
Rescues larval viability and locomotion defects and only partially restores U5 and U12 snRNA levels in the null mutant. Weakly inhibits homodimer formation. Does not affect protein stability.
Abolished formation of a phase-separated membraneless compartment.
Does not affect binding to N6-methyladenosine (m6A)-containing mRNAs, while reducing binfing t unmodified mRNAs.
Does not affect binding to N6-methyladenosine (m6A)-containing mRNAs.
Fragile X messenger ribonucleoprotein 1 homolog
Impairs RNA-binding. Strongly reduced binding to N6-methyladenosine (m6A)-containing mRNAs.
Strongly reduced binding to N6-methyladenosine (m6A)-containing mRNAs.
Probably constitutively active (GTP-locked form). Does not affect interaction with CG11448.
Probably constitutively inactive (GDP-locked form). Abolishes interaction with CG11448.
Queuine tRNA-ribosyltransferase accessory subunit 2
Copper type II ascorbate-dependent monooxygenase C-terminal
Copper type II ascorbate-dependent monooxygenase N-terminal
Peptidylglycine alpha-hydroxylating monooxygenase
Abolishes homodimerization and subcellular targeting of pip.
Affects subcellular targeting of pip but not homodimerization.
Affects subcellular targeting of pip; when associated with Q-212.
Affects subcellular targeting of pip; when associated with S-219.
Does not affect homodimerization. Abolishes homodimerization and subcellular targeting of pip; when associated with N-31.
Does not affect subcellular targeting of pip.
Endoplasmic reticulum resident protein 29 C-terminal
Impairs homodimerization. Abolishes homodimerization and subcellular targeting of pip; when associated with S-41.
Translocon-associated protein subunit beta
Probable methyltransferase-like protein 15 homolog
Thioredoxin-dependent peroxide reductase, mitochondrial
Eukaryotic translation initiation factor 3 subunit C
Mediator of RNA polymerase II transcription subunit 1
Mediator of RNA polymerase II transcription subunit 6
V-type proton ATPase 16 kDa proteolipid subunit c
In xmas-2-C; no effect on interaction with Orc3.
In xmas-2-N; abolishes interaction with Orc3.
In xmas-2-dCID; no effect on interaction with Orc3.
In xmas-2-dM; no effect on interaction with Orc3.
In xmas-2-dRRM; no effect on interaction with Orc3.
Translationally-controlled tumor protein homolog
Structure-specific endonuclease subunit SLX1 homolog
ATP synthase F1 complex delta/epsilon subunit N-terminal
Abnormal aggregation of Golgi apparatus and disrupted cleavage furrow ingression in early embryos. May be insensitive to Asap activation.
Important for the stable binding to the membranes
No defect in Golgi apparatus and cleavage furrow ingression in early embryos.
Has no effect on nervous system function but reduces binding to Pka-C3.
In allele sws-4; age-dependent neurodegeneration.
In allele sws-5; age-dependent neurodegeneration.
Beta-alanyl-bioamine nonribosomal peptide synthetase ebony
Impairs attachment of prosthetic group pantetheine 4'-phosphate and thus, the transfer of beta-alanine to the carrier domain. No effect on beta-alanine adenylation. Causes dark body pigmentation.
Cytosolic Fe-S cluster assembly factor Nubp1 homolog
Hepatocyte growth factor-regulated tyrosine kinase substrate
Probable cytochrome P450 12c1, mitochondrial
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1
ADP-ribosylation factor-like protein 6-interacting protein 1
Mitochondrial import inner membrane translocase subunit Tim10B
Reduced activity and lack of response to Ras85D or rl stimulation.
In strain: MEL14, ZBMEL82, ZBMEL131, ZBMEL145, ZBMEL157, ZBMEL229, ZBMEL377, ZBMEL384 and ZBMEL398.
In strain: MEL14, ZBMEL82, ZBMEL95, ZBMEL131, ZBMEL145, ZBMEL157, ZBMEL229, ZBMEL377 and ZBMEL398.
In strain: ZBMEL82, ZBMEL95, ZBMEL131, ZBMEL145, ZBMEL157, ZBMEL229, ZBMEL377 and ZBMEL398.
Probable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase
Histone acetyl transferase HAT1 N-terminal
Fanconi anaemia group A protein N-terminal
Abolishes binding to Drice and fails to inhibit cell death. No effect on binding to Dredd.
Abolishes binding to Drice. Loss of immunity to Gram-negative bacteria; when associated with A-163.
Death-associated inhibitor of apoptosis 2
Fails to bind to Dredd and promote its polyubiquitylation.
Loss of caspase-mediated cleavage, failure to protect against Drice-mediated cell death and loss of binding to Drice.
No effect on binding to Drice. Loss of immunity to Gram-negative bacteria; when associated with A-263.
Thiamin pyrophosphokinase thiamin-binding
Increases Ca(2+) influx through activation of CRAC channels and arrests cell growth.
Small ribosomal subunit protein eS4 C-terminal
Small ribosomal subunit protein eS4 N-terminal
Small ribosomal subunit protein eS4 central region
Cyclic AMP response element-binding protein A
For poly [ADP-ribose] polymerase activity
Cilia- and flagella-associated protein 20
In strain: KY02-C331, KY02-C392 and Oregon-R.
In dbtL; lengthens the behavioral period.
In dbtS; shortens the behavioral period.
Probable isoaspartyl peptidase/L-asparaginase CG7860 alpha chain
Probable isoaspartyl peptidase/L-asparaginase CG7860 beta chain
Multifunctional methyltransferase subunit TRM112-like protein
Disrupts Ca(2+) inflow through the channel. Calmodulin has little effect on Ca(2+) flow.
Does not abolish Ca(2+) inflow through the channel. Calmodulin has no effect on initial rates.
Transient-receptor-potential-like protein
Probable cytochrome P450 12a4, mitochondrial
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Ubiquitin carboxyl-terminal hydrolase 32
Adrenodoxin-like protein 1, mitochondrial
Organic solute transporter alpha-like protein
Ribonucleoside-diphosphate reductase large subunit
Signal transducer and transcription activator
Alpha-2-macroglobulin receptor-associated protein
Loss of peptidoglycan-induced oligomerization. Loss of DAP-type peptidoglycan muropeptide recognition.
Loss of peptidoglycan-induced oligomerization. Strongly reduced affinity for peptidoglycan. Loss of DAP-type peptidoglycan muropeptide recognition.
Strongly reduced affinity for peptidoglycan. Loss of DAP-type peptidoglycan muropeptide recognition.
Vacuolar protein sorting-associated protein 51 homolog
NFU1 iron-sulfur cluster scaffold homolog, mitochondrial
O-linked (Xyl...) (glycosaminoglycan) serine
Calcium-activated potassium channel BK alpha subunit
Putative mitogen-activated protein kinase kinase kinase 7-like
Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel
Dynein axonemal assembly factor 3 homolog
Zinc finger CCCH-type with G patch domain-containing protein
Does not rescue the phenotype of Pink1-null mutants which are unable to maintain neurotransmitter release at neuromuscular junctions (NMJ) during high-frequency stimulation (10 Hz). Rescues the climbing deficit of Pink1-null mutants.
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
Rescues some phenotypes of Pink1-null mutants by re-enabling maintained neurotransmitter release at neuromuscular junctions (NMJ) during high-frequency stimulation (10 Hz), by restoring mitochondria cristae structural organization and by improving climbing activity; does not restore muscle morphology and rescues only partially flight defects in the same mutants.
Loss of autoinhibition mediated by self-association results in rotation defects in the adult eye.
Loss of autoinhibition mediated by self-association results in severe eye defects including loss of R-cells.
Detected in spermatocyte cysts during meiosis but expression is diffuse. No localization to the fusome or actin cones.
Necessary and sufficient for recruitment to the fusome and actin cones of spermatocyte cysts
ATP-binding cassette sub-family D member 1
In vret(39); egg chambers are defective with abnormal nurse cell numbers and improper oocyte positioning. Follicle cells often fail to encapsulate egg chambers, and occasionally form disorganized multicellular layers.
In vret(46); egg chambers are defective with abnormal nurse cell numbers and improper oocyte positioning. Follicle cells often fail to encapsulate egg chambers, and occasionally form disorganized multicellular layers.
In vret(48-15); ventralized eggs with no defects in somatic gonadal cell patterning, germ cell differentiation or oocyte specification.
In vret(48-60); the germarium is filled with germ cells that maintain a round spectrosome, suggesting failure of germline stem cells to differentiate.
In vret(49); ventralized eggs with no defects in somatic gonadal cell patterning, germ cell differentiation or oocyte specification.
Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme
Putative fatty acyl-CoA reductase CG5065
Abolishes nucleosome mobilization. Retains ATPase activity but is unable to bind DNA or mononucleosomes.
Chromodomain-helicase-DNA-binding protein 3
No effect on ATPase activity or nucleosome mobilization, and is able to bind DNA and mononucleosomes.
[Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial
Induces a fourfold reduction in interaction with sina and impairs ttk degradation.
Induces a twofold reduction in interaction with sina and impairs ttk degradation.
No effect in interaction with sina or ttk degradation.
Impairs binding to histone H3 and histone H4 and transcriptional silencing.
Abolishes L,D-carboxypeptidase activity on DAP-type PGN.
Abolishes PGN-binding and activation of Toll pathway.
Abolishes PGN-binding and activation of Toll pathway. Abolishes L,D-carboxypeptidase activity on DAP-type PGN.
Does not affect activation of Toll pathway.
In seml; induces susceptibility to Gram-positive bacterial infection.
Increases PGN-binding and activation of Toll pathway.
Strongly reduces PGN-binding and activation of Toll pathway.
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Coiled-coil domain-containing protein 22 homolog
Interaction with activated Rac1 and Rac2
RNA polymerase II-associated protein 1 C-terminal
RNA polymerase II-associated protein 1 N-terminal
Mediator of RNA polymerase II transcription subunit 16
Potassium voltage-gated channel protein Shaker
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wuho
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
DnaJ homolog subfamily C member 25 homolog
Stimulator of interferon genes protein homolog
Transcription termination factor 5, mitochondrial
Mediator of RNA polymerase II transcription subunit 30
Putative ATP-dependent RNA helicase CG14443
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
Autolysis site shifted to nearby, less-active site(s).
Autolysis site shifted to nearby, less-active sites.
Mediator of RNA polymerase II transcription subunit 4
In strain: CT97_3, MFL97_1 and ZIM(S)37.
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
cAMP-dependent protein kinase type I regulatory subunit
Adrenodoxin-like protein 2, mitochondrial
Displays defects in chp trafficking to the membrane and mislocalization of ninaE, Rh3 and Rh4 in photoreceptors. Shows reduced levels of chp and ninaE, small rhabdomeres with severely disorganized microvilli and retinal degeneration; when associated with or without A-63 or L-310. Mild photoreceptor cell and microvillar disorganization; when associated with A-306. No phenotype; when associated with L-62.
Mild photoreceptor cell and microvillar disorganization; when associated with V-276.
No phenotype; when associated with V-276.
Shows reduced levels of chp and ninaE, small rhabdomeres with severely disorganized microvilli and retinal degeneration; when associated with V-276.
In csn5-3; disrupts R cell projections. Impairs the interaction with Trc8.
Transport and Golgi organization protein 11
Putative inactive polypeptide N-acetylgalactosaminyltransferase 11
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4
No effect on lethality; when associated with A-831.
No effect on lethality; when associated with A-843.
Rescues dorsal closure defect, muscle attachment defect, disorganized ommatidial array and loss of cell layer attachment in mutants; when associated with A-817.
Rescues dorsal closure defect, muscle attachment defects, disorganized ommatidial array and loss of cell layer attachment in mutants; when associated with A-807.
Rescues muscle attachment defect and loss of cell layer attachment in mutants; when associated with A-811.
Rescues muscle attachment defect and loss of cell layer attachment in mutants; when associated with A-814.
Polypeptide N-acetylgalactosaminyltransferase 5
In isoform D, isoform L, isoform O, isoform R and isoform W.
In isoform L, isoform E, isoform Oand isoform R.
In isoform S, isoform U, isoform W, isoform X and isoform V.
Molybdopterin synthase catalytic subunit
Probable G-protein coupled receptor Mth-like 14
Alpha N-terminal protein methyltransferase 1
Ribonucleoside-diphosphate reductase subunit M2
26S proteasome non-ATPase regulatory subunit 11
In allele mago-93D; expression of rolled/MAPK in developing eye and wing tissue is severely reduced, and photoreceptor differentiation is impaired.
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
In dor-1; diminished fertility and an orange eye color.
In dor-30; Accumulation of the mature form of Cp1.
In dor-36; reduced endolysosomal trafficking and thus reduced number of effective vesicles released in response to a nerve impulse (quantal content). This is likely largely due to the reduction in readily releasable vesicles. Accumulation of the mature form of Cp1. Expression in sky mutants partially rescues increased neurotransmitter release at the larval neuromuscular junction and neurodegeneration in the retina. However it does not rescue the excessive recycling of vesicles to endosomal compartments in sky mutants.
Vacuolar protein sorting-associated protein 18 homolog
Loss of enzyme activity. Increase in apoptotic cells in the eye and wing. Increase in bristle number in the interommatidial lattice and decrease in pigment cell number. Disrupts vesicular localization of dock in spermatocytes. Fails to rescue the nurse cell plasma membrane defects and male sterility observed in null mutants. Fails to rescue the small eye phenotype induced by hid but able to rescue the small eye phenotype induced by rpr.
Loss of enzyme activity. Many embryos die before hatching. Fails to promote yki-dependent tissue growth in the eye and wing. Overexpression in wing imaginal disks frequently results in wings with blisters and ectopic veins. Eyes are disorganized and ommatidia are almost completely absent, eye bristles are not present in posterior two-thirds of the eye and bristle clusters occur at the anterior end. Increased Egfr endocytosis in embryos. No effect on Dpp expression in the leading edge cells.
Probable cytochrome P450 12b2, mitochondrial
26S proteasome non-ATPase regulatory subunit 14
Serine/threonine-protein phosphatase 6 catalytic subunit
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Lack of heparan sulfate glycosaminoglycan modification. Does not affect binding to nord; when associated with A-549 and A-569.
Lack of heparan sulfate glycosaminoglycan modification. Does not affect binding to nord; when associated with A-549 and A-573.
Lack of heparan sulfate glycosaminoglycan modification. Does not affect binding to nord; when associated with A-569 and A-573.
N-linked (GlcNAc...) asparagine; atypical
O-linked (Xyl...) (heparan sulfate) serine
Small nuclear ribonucleoprotein-associated protein B
Unable to localize to the pole plasm; when associated with G-130; L-145; L-174; L-181; L-189 and G-196.
Unable to localize to the pole plasm; when associated with L-112; G-130; L-145; L-174; L-181 and G-196.
Unable to localize to the pole plasm; when associated with L-112; G-130; L-145; L-174; L-181 and L-189.
Unable to localize to the pole plasm; when associated with L-112; G-130; L-145; L-174; L-189 and G-196.
Unable to localize to the pole plasm; when associated with L-112; G-130; L-145; L-181; L-189 and G-196.
Unable to localize to the pole plasm; when associated with L-112; G-130; L-174; L-181; L-189 and G-196.
Unable to localize to the pole plasm; when associated with L-112; L-145; L-174; L-181; L-189 and G-196.
Transcription factor glial cells missing
Heterogeneous nuclear ribonucleoprotein 27C
Abolishes homodimerization but not regulatory function on Slo; when associated with A-59.
Abolishes homodimerization but not regulatory function on Slo; when associated with A-63.
In ninaB(P315); abolishes catalytic activity.
Glutaredoxin domain-containing cysteine-rich protein CG31559
Iron-sulfur cluster assembly 1 homolog, mitochondrial
Post-GPI attachment to proteins factor 2-like
ATPsynthase alpha/beta subunit N-terminal extension
Serine/threonine-protein phosphatase 2B catalytic subunit 3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog
Fork head domain transcription factor slp2
tRNA (32-2'-O)-methyltransferase regulator THADA
Transcription initiation factor TFIID subunit 7
3-phosphoinositide-dependent protein kinase 1
Does not affect acetyltransferase activity.
Reduced acetyltransferase activity; when associated with A-46.
Reduced acetyltransferase activity; when associated with A-53.
Reduced acetyltransferase activity; when associated with A-83.
Reduced acetyltransferase activity; when associated with A-98.
Eukaryotic translation initiation factor 2-alpha kinase
Phosphoserine; by PHK; in form phosphorylase A
Facilitated trehalose transporter Tret1-1
Loss of conjugation of target proteins results in loss of urmylation and response to oxidative stress.
Tetratricopeptide repeat protein 14 homolog
Retinoblastoma-associated protein N-terminal
RNA polymerase III subunit RPC82-related helix-turn-helix
26S proteasome regulatory subunit Rpn7 N-terminal
DET1- and DDB1-associated protein 1 N-terminal
In 2S-A; loss of phosphorylation. In the presence of aPKC remains localized to the cell cortex and does not display any decrease in phospholipid binding; when associated with A-48.
In 2S-A; loss of phosphorylation. In the presence of aPKC remains localized to the cell cortex and does not display any decrease in phospholipid binding; when associated with A-52.
In 2S-D; phosphomimetic mutant that displays reduced cortical localization but no significant decrease in phospholipid binding; when associated with D-48.
In 2S-D; phosphomimetic mutant that displays reduced cortical localization but no significant decrease in phospholipid binding; when associated with D-52.
In 4R-D; phosphomimetic mutant that displays decreased phospholipid binding and reduced cortical localization; when associated with D-46 and D-47.
In 4R-D; phosphomimetic mutant that displays decreased phospholipid binding and reduced cortical localization; when associated with D-54 and D-55.
Loss of binding affinity to Nak and drop in binding to single helical peptide.
Loss of binding affinity to Nak and single helical peptide.
Slight reduction in cortical localization.
Methyl-CpG binding protein 2/3 C-terminal
Slihgtly reduces complex helicase activity.
DNA mismatch repair protein spellchecker 1
DNA mismatch repair proteins mutS family
Intermembrane lipid transfer protein Vps13D
Loss of 'Lys-63'-linked polyubiquitin chain binding.
In stil-1; induces female infertility due to germ ovary defects.
In stil-2; induces female infertility due to germ ovary defects. Loss of chromatin association.
In stil-4; induces female infertility due to germ ovary defects. Loss of chromatin association.
Abolished E3 ubiquitin-protein ligase activity and ability to generate large endosomes when overexpressed.
Cysteine sulfinic acid (-SO2H); alternate
Ubiquitin-activating enzyme E1 C-terminal
Results in eye color defects caused by oversized pigment granules; when associated with 2772-W--K-3535.
Results in eye color defects caused by oversized pigment granules; when associated with 3160-W--K-3535.
Ragulator complex protein LAMTOR3 homolog
BLOC-1-related complex subunit 8 homolog
Probable trafficking protein particle complex subunit 13 homolog
Decreased inhibition of proteolytic activation of phenoloxidase (PO).
Fails to inhibit proteolytic activation of phenoloxidase (PO).
Probable 26S proteasome non-ATPase regulatory subunit 3
In rogdi(del); greatly reduced protein half-life; localization to distinct cytoplasmic inclusions; insomnia-like behaviors with sleep fragmentation and delay in sleep initiation in males and virgin females but not in mated females.
ATP-dependent zinc metalloprotease YME1L
In D44; reduces polyubiquitination by Diap2, abolishes rel cleavage and blocks expression of DptA following bacterial infection. No effect on binding to Diap2 or Fadd, processing, dimerization, catalytic activity or stability.
In L23; blocks expression of DptA following bacterial infection.
PP2C-like domain-containing protein CG9801
Interleukin enhancer-binding factor 2 homolog
Cold shock domain-containing protein CG9705
Presenilins-associated rhomboid-like protein, mitochondrial
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12)
Large ribosomal subunit protein uL6 alpha-beta
Probable mitochondrial import inner membrane translocase subunit Tim17 4
Probable G-protein coupled receptor Mth-like 7
Probable small nuclear ribonucleoprotein Sm D2
EF-hand domain-containing protein D2 homolog
Heterogeneous nuclear ribonucleoprotein A1
Abolishes phosphorylation. Reduces kinase activity.
Histone-lysine N-methyltransferase Suv4-20
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1)
Spermatogenesis-associated protein 6 N-terminal
ATPase family AAA domain-containing protein 3A homolog
Decreases the number of mitochondria in motor neurons or in body wall muscles.
RNA polymerase subunit H/Rpb5 C-terminal
Probable E3 ubiquitin-protein ligase sinah
In YP3s1; synthesized in the fat body, but not secreted, probably due to the amino acid mutation in the signal peptide.
Helical; Signal-anchor for type III membrane protein
Echinoderm microtubule-associated protein-like CG42247
ER membrane protein complex subunit 1 C-terminal
Loss of catalytic activity and dimerization.
In isoform 9, isoform 11 and isoform 13.
Mediator of RNA polymerase II transcription subunit 9
Decreases methylation of position 32 in tRNA(Phe). Sensitizes flies to infection by Drosophila C virus (DCV). Derepresses piRNA pathway-mediated transposable element silencing. Leads to locomotor defects.
tRNA (cytidine(32)-2'-O)-methyltransferase
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
In strain: ZBMEL84, ZBMEL95, ZBMEL131 and ZBMEL157.
Partially rescues sterility when transfected in a homozygous mutant fly.
Zinc finger MYND domain-containing protein 10 homolog
Vacuolar protein sorting-associated protein 54 N-terminal
TNF family profile domain-containing protein
Impairs chromo domain folding and histone H3 binding. Does not affect piwi binding.
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II
In isoform 1, isoform C, isoform G and isoform H.
Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal
Probable sodium/potassium/calcium exchanger CG1090
RNA-binding protein Musashi homolog Rbp6
Ubiquitin-fold modifier-conjugating enzyme 1
Protein TsetseEP domain-containing protein
Nuclear envelope integral membrane protein
Nucleolar pre-ribosomal-associated protein 1 C-terminal
Nucleolar pre-ribosomal-associated protein 1 N-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Neither inactivation nor afterpotential protein G
NADH:ubiquinone oxidoreductase chain 4 N-terminal
8 X 8 AA approximate repeats of Y-S-A-P-A-A-P-A
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
DNA-directed RNA polymerase I subunit RPA2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase
Rapamycin resistance and loss of activity.
Cytochrome c oxidase subunit 7A, mitochondrial
In PB70; weak allele that only affects female fertility without affecting male fertility.
Inactive peptidyl-prolyl cis-trans isomerase shutdown
Probable peptidoglycan muropeptide transporter SLC46
Eukaryotic translation initiation factor 3 subunit E
Proteasome-associated protein ECM29 homolog
Guanine nucleotide-binding protein subunit beta-1
22 X 7 AA approximate tandem repeats of T-[ETK]-[PT]-P-[RKT]-C-[ERK]
In strain: Berkeley, Oregon-R and Oregon-R(2/10).
Important for beta-aspartyl-AMP intermediate formation
In allele shi-TS1; temperature sensitive larval and adult paralysis.
In allele shi-TS2; temperature sensitive larval and adult paralysis.
Leucine-zipper-like transcriptional regulator 1 homolog
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
Sufficient for binding to IntS1 and IntS9 and for 3'-end snRNA processing
Nuclear envelope phosphatase-regulatory subunit 1 homolog
ATP-grasp fold succinyl-CoA synthetase-type
V-type proton ATPase catalytic subunit A isoform 1
Eukaryotic translation initiation factor 4E transporter
Glycosyl transferase family 28 C-terminal
Reduced specificity and affinity for DNA.
Segmentation polarity homeobox protein engrailed
DnaJ homolog subfamily C member 5 homolog
Probable citrate synthase, mitochondrial
Serine protease gd N-terminal domain-containing protein
Reduced localization to the lamellipodia, likely resulting from decreased interaction with Cortactin.
Transient receptor potential cation channel protein painless
ER membrane protein complex subunit 7 beta-sandwich
Probable G-protein coupled receptor Mth-like 5
Pseudouridine synthase I TruA alpha/beta
Sodium/potassium-transporting ATPase subunit beta-2
Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
Abolishes interaction with nxf2 and decreases protein stability.
Necessary for interaction with nxf2 and protein stability
Pterin-4-alpha-carbinolamine dehydratase
Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase
In strain: Australia 2, Kenya 38, Kenya 43, Peru and USA 3.
Prevents binding to HP1 hinge domain but no effect on binding to HP1 chromoshadow domain.
Su(var)205-binding Pro-containing repeat 1
Su(var)205-binding Pro-containing repeat 2
Rapamycin-insensitive companion of mTOR N-terminal
Rapamycin-insensitive companion of mTOR middle
Mitochondrial import inner membrane translocase subunit TIM14
Third instar larval lethal. First and second instar larvae are reduced in size.
In Fez-1; Reduced protein stability resulting is abnormal expansion of Type II neuroblast lineage due to dedifferentiation of intermediate neuronal progenitors (INPs). In lamina L3 neurons, growth cones display defects in morphology and incorrect targeting to the proximal domain of the outer medulla. Reduced expression of cell surface proteins dpr17 and dpr1 as well as the netrins NetA and NetB in L3 neurons. No effect on L3 dendrite branching and M3 layer innervation of Tm9 neurons.
In cdc2-D57; embryonic or larval-pupal lethal.
In cdc2-E1-24; larval-pupal lethal with some adult escapers.
In cdc2-E1-4; larval-pupal lethal with some adult escapers.
Results in progressive degeneration of photoreceptors and glia that show accumulation of large lipid droplets. Results in reduced cell proliferation, up-regulation of the mitochondrial unfolded protein response and cell aberrant mitochondrial respiration leading to an increased oxidative stress.
Semi-viable with reduced cell proliferation and lifespan including progressive degeneration of photoreceptors and glia. Shows aberrant mitochondrial respiration probably leading to an increased oxidative stress. Shows high levels of reactive oxygen species (ROS) and accumulation of lipid droplets in pigment and epithelial glia. Lipid droplet accumulation occurs early, prior to the onset of neurodegeneration.
Lateral signaling target protein 2 homolog
In strain: Ann Arbor1, DPCNBW, Kakamega-b1, Kakamega-b3, Kakamega-b4, Kenya-HLa3, Kenya-HLa6, Makindu-b5 and Reids2.
In strain: Kenya-HLa3, Kenya-HLa6, Kakamega-b1 and Makindu-b1.
Exosome complex component CSL4 C-terminal
In KRm12; lethal due to lower enzyme activity; when associated with S-97.
In KRm4; lethal due to loss of catalytic activity; when associated with S-97.
In KRm5; lethal due to loss of phosphorylated active site intermediate; when associated with S-97.
In KRm7; lethal due to loss of phosphorylated active site intermediate; when associated with S-97.
In KRm9; lower enzyme activity; when associated with S-97.
In KRn3; lethal due to loss of phosphorylated active site intermediate; when associated with S-97.
Killer of prune mutation. Conditionally dominant lethal mutation in individuals with a null mutation in the prune gene.
Post-GPI attachment to proteins factor 2
Zinc finger CCHC domain-containing protein 8 homolog
Gamma-glutamylcyclotransferase AIG2-like
Putative gamma-glutamylcyclotransferase CG2811
In allele RU-35; bicaudal phenotype; lowers RNA-binding.
Cleavage and polyadenylation specificity factor subunit 1
Poly-KR; increase in apoptosis when overexpressed in muscle cells, resulting in wing posture abnormalities; when associated with R-11, R-19 and R-109.
Poly-KR; increase in apoptosis when overexpressed in muscle cells, resulting in wing posture abnormalities; when associated with R-11, R-19 and R-52.
Poly-KR; increase in apoptosis when overexpressed in muscle cells, resulting in wing posture abnormalities; when associated with R-11, R-52 and R-109.
Poly-KR; increase in apoptosis when overexpressed in muscle cells, resulting in wing posture abnormalities; when associated with R-19, R-52 and R-109.
Significant increase in apoptosis when overexpressed in muscle cells, resulting in severe wing posture abnormalities and impaired climbing ability.
Voltage-dependent anion-selective channel
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Probable histone-lysine N-methyltransferase CG1716
In rumi-79; complete loss of enzyme activity.
Interaction with the consensus sequence C-X-S-X-[PA]-C in peptide substrates
Nearly complete loss of enzyme activity.
Coiled-coil and C2 domain-containing protein 2A
Transcription initiation factor TFIID subunit 1
Prion-like domain necessary for both protein assembly and membrane targeting
Low molecular weight phosphotyrosine protein phosphatase 1
Mitochondrial import inner membrane translocase subunit Tim16
Probable cytochrome P450 12d1 proximal, mitochondrial
Mediator of RNA polymerase II transcription subunit 23
Casein kinase substrate phosphoprotein PP28
7-methylguanosine phosphate-specific 5'-nucleotidase
Considerable increase (12-fold) in KM for m(7)GMP and decreases KM 3-fold for CMP. Decreases KM 6-fold for m(7)GMP and increases KM 2-fold for CMP; when associated with His-75. Decreases KM 1.5-fold for m(7)GMP and increases KM 1.5-fold for CMP; when associated with Asn-76. Increases KM 7-fold for CMP; when associated with 75-His--Asn-76.
Decreases KM 6-fold for m(7)GMP. Decreases KM 1.5-fold for m(7)GMP and increases KM 1.5-fold for CMP; when associated with Trp-121.
Increases KM 3-fold for m(7)GMP and increases KM 10-fold for CMP. Decreases KM 6-fold for m(7)GMP and increases KM 2-fold for CMP; when associated with Trp-121.
Increases KM 7-fold for CMP; when associated with Trp-121.
VWFA and cache domain-containing protein CG16868
Serine/threonine-protein phosphatase Pgam5, mitochondrial
Beta-alanyl-dopamine/carcinine hydrolase
Beta-alanyl-dopamine/carcinine hydrolase alpha subunit
Beta-alanyl-dopamine/carcinine hydrolase beta subunit
Impairs self-processing. Does not affect homodimerization of the unprocessed form. Loss of carcinine hydrolysis.
In tan1 and tan4; impairs self-processing. Loss of beta-alanyl-dopamine hydrolysis. Lighter pigmentation of the body. In newly emerged female imagoes and fly frass, beta-alanyl-dopamine (NBAD) levels are increased about 3-fold while dopamine levels are reduced by 50 percent. Reduces head histamine contents. Increases carcinine levels. Photoreceptor response to light is abnormal. Electroretinogram (ERG) recordings lack normal 'on' and 'off' transients suggesting an impaired synaptic transmission to postsynaptic cells. Reduces number of synaptic vesicles at the terminal of photoreceptor cells L1-L6.
In tan5; reduces stability resulting in rapid protein degradation. 4-fold increase in affinity for carcinine. No effect on self-processing.
Neither inactivation nor afterpotential protein C
Protocadherin-like wing polarity protein stan
In allele Adh-F, allele Adh-F-CHD, allele Adh-71K, allele Adh-JA-F and in strain: Berkeley.
N-linked (GlcNAc...) (complex) asparagine
N-linked (GlcNAc...) (complex) asparagine; alternate
N-linked (GlcNAc...) (high mannose) asparagine
N-linked (GlcNAc...) (high mannose) asparagine; alternate
N-linked (GlcNAc...) (paucimannose) asparagine
N-linked (GlcNAc...) (paucimannose) asparagine; alternate
Janus kinase and microtubule-interacting protein C-terminal
Causes the differentiation of ectopic vein stretches in several regions of the wing. Shows elimination of distal stretches of longitunal veins L2-L5. Causes substitution of the wing by proximal hinge tissue. Affects the development of macrochaetae or the formation of the thorax.
Dual specificity protein phosphatase Mpk3
Reduces binding affinity to substrate by approximately 18-fold.
Loss of binding to Rae1 and unable to rescue synaptic terminal overgrowth in mutants.
Unable to rescue synaptic terminal overgrowth in mutants but has no effect on binding to Rae1.
Unable to rescue synaptic terminal overgrowth in mutants but has no effect on binding to Rae1; when associated with 1012-E--E-1014.
Unable to rescue synaptic terminal overgrowth in mutants but has no effect on binding to Rae1; when associated with 671-T--R-1011 DEL.
Unable to rescue synaptic terminal overgrowth in mutants but has no effect on binding to Rae1; when associated with S-5038.
Unable to rescue synaptic terminal overgrowth in mutants but has no effect on binding to Rae1; when associated with S-5041.
In allele wg-IL114; temperature sensitive lethal.
Ubiquitin-like domain-containing CTD phosphatase 1
Loss of GTPase activity. Loss of endoplasmic reticulum membrane fusion. Does not oligomerize.
Probable V-type proton ATPase subunit d 2
Abolishes phosphorylation and interaction with 14-3-3-zeta; when associated with A-54.
Abolishes phosphorylation and interaction with 14-3-3-zeta; when associated with A-79.
Probable U2 small nuclear ribonucleoprotein A'
Release factor glutamine methyltransferase N-terminal
Large ribosomal subunit protein uL2 C-terminal
In isoform 11.15, isoform 11.27 and isoform 11.7.
In isoform 8.24, isoform 11.32 and isoform 11.6.
Not cleaved when expressed with activated SPE.
COP9 signalosome complex subunit 9 homolog
WD repeat-containing protein on Y chromosome
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
4 X 8 AA tandem repeats of T-S-A-S-A-T-T-T
Required for P-body targeting and interaction with DCP1A
Strongly reduced interaction with DCP1A, but no effect on P-body targeting; when associated with A-42.
Strongly reduced interaction with DCP1A, but no effect on P-body targeting; when associated with A-44.
Strongly reduced interaction with DCP1A. No effect on P-body targeting.
Phosphatidylinositol-specific phospholipase C X
Pyridine nucleotide-disulphide oxidoreductase dimerisation
N-acetylglucosamine-6-phosphate deacetylase
In strain: NC304, NC322, NC359, NC361 and NC399.
Biogenesis of lysosome-related organelles complex 1 subunit 3
Piezo non-specific cation channel R-Ras-binding
Piezo-type mechanosensitive ion channel component
Gamma-secretase-activating protein C-terminal
Carnitine O-palmitoyltransferase N-terminal
Putative mitogen-activated protein kinase 14C
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members
Ubiquitin carboxyl-terminal hydrolase 30 homolog
Calcium uptake protein 1 homolog, mitochondrial
In mus304-3; induces abnormal bristle morphology, decreased meiotic recombination and arrested embryonic development.
In mus304-4; induces abnormal bristle morphology, decreased meiotic recombination and arrested embryonic development.
In mus304-6; induces abnormal bristle morphology, decreased meiotic recombination and arrested embryonic development.
In strain: MW11, MW27, MW38, MW56, MW9, NC390 and NC740.
In strain: MW11, MW27, MW6, MW9 and NC774.
In strain: MW56, NC335, NC336, NC362, NC740 and NC774.
In strain: NC304, NC335, NC350, NC397, NC732 and MW9.
Histone-lysine N-methyltransferase, H3 lysine-79 specific
U3 small nucleolar RNA-associated protein 13 C-terminal
Transcription initiation factor TFIID subunit 5
Nitric oxide synthase-interacting protein homolog
Nitric oxide synthase-interacting protein zinc-finger
In allele scra1. Strong maternal effect allele; abrogates cellularization of syncytial embryos.
In allele scra3. Weak maternal effect allele; abrogates separation of pole cells.
In allele scra4. Strong maternal effect allele; abrogates cellularization of syncytial embryos.
In allele scra5. Strong maternal effect allele; abrogates cellularization of syncytial embryos.
In alleles scra1; scra3; scra4; and scra5.
Interaction with and bundling of F-actin
Results in reduced viability, shortened lifespan, age-dependent wing posture and locomotor defects. Results in increased steady-state levels of specific neuronal mRNAs such as Arc1 and wfs1.
Results in reduced viability, shortened lifespan, age-dependent wing posture and locomotor defects. Shows a mushroom body beta-lobe midline-crossing defect. Results in increased steady-state levels of specific neuronal mRNAs such as Arc1 and wfs1.
Putative ferric-chelate reductase 1 homolog
In allele 339; strong reduction in head size.
Does not affect subcellular location or interaction with Rab11. Fails to inactivate Rab11.
Ecotropic viral integration site 5 ortholog
Fails to export proteins containing leucine-rich nuclear export signal (NES) from the nucleus.
Results in lethality at larval stage. This is reversed by removal of one chromosome copy of Nup214. Fails to export proteins containing leucine-rich nuclear export signal (NES) from the nucleus.
Vacuolar protein sorting-associated protein 16B
Mitochondrial proton/calcium exchanger protein
Blocks ability of fj to enhance binding to ds.
Essential for stability of mitochondrial electron chain complexes I and V, and promotes interaction with ND-24
In ft61; strong overgrowth of eye imaginal disks. Binding to Fbxl7 is not affected.
Moderately delays development and reduces lifespan. In wing imaginal disks, increases its transcript level.
Translocon-associated protein subunit alpha
Protein tumorous imaginal discs, mitochondrial
Serine/threonine-protein phosphatase PP2A
Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type
Nedd8-activating enzyme E1 catalytic subunit
Impaired conversion of the pre-RISC complex, containing duplex siRNA, to the holo-RISC complex, containing single-stranded guide siRNA.
Ribosome biogenesis protein BOP1 homolog
Leucine-rich repeat protein soc-2 homolog
Transient receptor potential cation channel subfamily A member 1
Transcription initiation factor TFIID subunit 12
Reduced survival rate after 50 days of age. Decreased aminoacylation, increased misacylation of non-cognate Tyr, increased amino acid misincorporation, ommatidia defects, neurodegeneration, impaired locomotive performance, reduced lifespan, smaller organ size due to apoptosis and increased ER stress; when associated with 'G-456' in alpha subunit.
Acetylcholine receptor subunit beta-like 2
Ribosomal RNA processing protein 1 homolog
Probable tRNA N6-adenosine threonylcarbamoyltransferase
Beta-adaptin appendage C-terminal subdomain
Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain
In P365; defective in the response to light due to rapid degeneration of photoreceptors.
In P365; photoreceptors respond normally to light.
Significant loss of Scm-binding activity.
Abolishes phosphorylation; when associated with A-190 and A-259.
Abolishes phosphorylation; when associated with A-44 and A-190.
Abolishes phosphorylation; when associated with A-44 and A-259.
Biogenesis of lysosome-related organelles complex 1 subunit 4
In Dif1; immune response defective. Reduced survival following infection with fungi, and reduced levels of Drs following immune challenge with fungi or bacteria. No down-regulation of the serpin Spn27A in response to bacterial infection. Ectopic bristles form on the dorsocentral, scutellar and lateral regions of the notum.
Alpha-N-acetylglucosaminidase C-terminal
Alpha-N-acetylglucosaminidase N-terminal
Alpha-N-acetylglucosaminidase tim-barrel
Histone-binding protein RBBP4 N-terminal
Lack of GTP-binding, defective light-induced internalization of TRPL, late-onset light-dependent photoreceptor degeneration and larval lethality.
Deubiquitinating enzyme MINDY-3/4 conserved
Ubiquitin carboxyl-terminal hydrolase MINDY-3 homolog
Severe retardation of TFAM degradation following mtDNA depletion.
In bowl2; embryonic lethal. Legs containing clones show fusion and truncation of tarsomeres and disrupted expression of the leg patterning genes bab2, dac and B-H1.
In bowl4; embryonic lethal with 50% larval/pupal escapers.
In bowl5; embryonic lethal; when associated with I-343 and K-345.
In bowl5; embryonic lethal; when associated with I-343 and P-609.
In bowl5; embryonic lethal; when associated with K-345 and P-609.
Mediator of RNA polymerase II transcription subunit 10
Small ribosomal subunit protein uS4 N-terminal
Choline O-acetyltransferase 13 kDa chain
Choline O-acetyltransferase 54 kDa chain
Choline O-acetyltransferase 67 kDa chain
Enhancer of yellow 2 transcription factor
Rhodanese domain-containing protein CG4456
Bifunctional glutamate/proline--tRNA ligase
Eukaryotic translation initiation factor 3 subunit D-2
Angiotensin-converting enzyme-related protein
Retains interaction with bcn92 and IscU.
Transducer of regulated CREB activity C-terminal
Transducer of regulated CREB activity N-terminal
In QE70; defects in female meiosis. Abolishes DNA-binding activity.
In QQ36; defects in female meiosis. Abolishes DNA-binding activity.
Mediator of RNA polymerase II transcription subunit 14
Chromatin target of PRMT1 protein C-terminal
Eukaryotic translation initiation factor 3 subunit H
Mitochondrial ribosome-associated GTPase 1
E3 ubiquitin-protein ligase RNF181 homolog
Actin-related protein 2/3 complex subunit 2
Translation machinery-associated protein 16 homolog
JmjC domain-containing histone demethylation protein 1
Required for nuclear localization and inhibition of Wnt signaling
tRNA-splicing endonuclease subunit Sen54 N-terminal
Does not affect binding to Elongin BC complex or vas.
Does not affect binding to Elongin BC complex. Abolishes interaction with vas.
Does not affect binding to Elongin BC complex. Decreases interaction with vas.
Involved in binding to the Elongin BC complex
In strain: NVIII-1, NVIII-18, NVIII-2, NVIII-22, NVIII-24, NVIII-41, NVIII-42, NVIII-46, NVIII-5, NVIII-9, NVIII-m12, NVIII-m15, NVIII-m19 and Oregon-R.
Partial loss of DNA-binding and significant decrease in transcriptional repressor activity. Complete loss of repressor activity; when associated with A-354.
Partial loss of DNA-binding and transcriptional repressor activity.
Significant loss of DNA-binding and transcriptional repressor activity. Complete loss of repressor activity; when associated with A-351.
U3 small nucleolar RNA-associated protein 15 C-terminal
Protein still life, isoforms C/SIF type 2
18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal
Probable ATP-dependent RNA helicase Dbp73D
Alanyl-transfer RNA synthetases family profile
Calcium-binding mitochondrial carrier protein Aralar1
In esg[VS8]; 50-fold reduction of affinity for DNA binding.
Serine/threonine-protein phosphatase rdgC
Dimethyladenosine transferase 2, mitochondrial
5 X 7 AA tandem repeats of [FS]-R-G-G-[EQ]-G-G
Enhances protein stability. Does not affect protein distribution in the oocyte.
Increase in RNA-binding and no significant change to RNA-dependent ATPase or unwinding activities.
Moderately decreased the RNA binding, abolished both the RNA-dependent ATPase and unwinding activities.
No change to RNA-binding, abolished unwinding activities and no significant change to RNA-dependent ATPase activity.
Reduction in RNA-binding, abolished unwinding activities and no significant change to RNA-dependent ATPase activity.
Reduction in RNA-binding, barely detectable RNA-dependent ATPase activity and completely defective unwinding activity.
Reduction in RNA-binding, drastic reduction in unwinding activities and no significant change to RNA-dependent ATPase activity.
Reduction in RNA-binding, drastic reduction in unwinding activities, no significant change to RNA-dependent ATPase activity.
Reduction in RNA-binding, reduced RNA-dependent ATPase and unwinding activities.
Reduction in RNA-binding, significantly reduced RNA-dependent ATPase and unwinding activities.
Required for posterior localization in oocyte
Strongly decreases interaction with gus.
Nascent polypeptide-associated complex subunit alpha
Probable ATP-dependent RNA helicase spindle-E
Peptidyl-prolyl cis-trans isomerase Fkbp12
In isoform 1, isoform C, isoform O and isoform R.
In isoform A, isoform C, isoform G, isoform W, isoform MS11, isoform O and isoform R.
In isoform W, isoform MS16 and isoform R.
Abolishes enzymatic activity; no change in interaction with MAD.
Abolishes interaction with MAD; when associated with A-544.
Abolishes interaction with MAD; when associated with F-541.
In ttv205; induces defects in wing patterning due to impaired movement of morphogens.
9 X 7 AA tandem repeats of G-G-G-Y-G-N-N
Decreases animal survival. No effect on head morphogenesis.
Increased interaction with ck and large percentage of detached scolopidia in Johnston's organs.
Large percentage of detached scolopidia in Johnston's organs but no effect on interaction with ck.
Small percentage of detached scolopidia in Johnston's organs but no effect on interaction with ck.
Glycosyl hydrolases family 22 (GH22) domain-containing protein
Adenylyltransferase and sulfurtransferase MOCS3
Cysteine persulfide intermediate; for sulfurtransferase activity
Glycyl thioester intermediate; for adenylyltransferase activity
In strain: LA116, LA25, LA4, MA24, MA45, MA50, MW37, MW6 and MW9.
In strain: LA116, MA45, MA50, MW37, MW6 and MW9.
In strain: LA116, MA45, MA50, MW37, MW6, MW9, NC52a and NC73a.
In strain: MA45, MA50, MW37, MW6 and MW9.
In strain: NC21a, NC52a, NC62a, NC73a and NC79b.
Serine/threonine-protein phosphatase 4 regulatory subunit 2
Anaphase-promoting complex subunit 1 C-terminal
Anaphase-promoting complex subunit 1 middle
Probable G-protein coupled receptor Mth-like 9
In strain: 2CPA1, 2CPA12, 2CPA43, 2CPA46, 2CPA51, 2CPA103 and 2CPA105.
In strain: 2CPA12, 2CPA43, 2CPA46, 2CPA51, 2CPA103 and 2CPA105.
Mostly localized to cytoplasm. Does not affect interaction with and protein level stabilization of ND-42.
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Malignant T-cell-amplified sequence 1 homolog
No effect on translation regulation activity.
No effect on translation regulation activity. Reduced translation regulation activity; when associated with A-119.
Reduced translation regulation activity. Further reduced translation regulation activity; when associated with A-119.
Solute carrier organic anion transporter family member 74D
eEF1A lysine and N-terminal methyltransferase homolog
Probable ATP-dependent RNA helicase CG8611
Complete loss of ability to inhibit translation, possibly due to disruption of interactions with prfA/RF1.
Critical for inhibition of translation, possibly due to its role in mediating interactions with bacterial 23S rRNA and peptide chain release factors
Critical for inhibition of translation, possibly due to its role in mediating the interaction with bacterial 23S rRNA
Critical for inhibition of translation, possibly due to its role in mediating the interaction with bacterial 23S rRNA and rplV/50S ribosomal protein L22
Enhanced translation inhibition efficiency.
In strain: 2CPA1, 2CPA12, 2CPA51, 2CPA105, 2CPA118, 2CPA122, 8B, 8D, 8E, 8F, 8G, 9A, 9B, 9C, 9D, 9E, 9F, 9G, 9H, 10B, 10F, 10G, 10H and Oregon-R; required for antibacterial activity against Providencia burhodogranariea.
No loss of translation inhibition activity.
No significant impact on translation inhibition efficiency.
Significant loss of antimicrobial activity.
Significant loss of translation inhibition activity, possibly due to disruption of interaction with bacterial 23S rRNA.
Significantly enhanced translation inhibition efficiency.
>D: In dim-arm; Does not form dimers even in the presence of spitz; when associated with E-341; A-342; E-346; A-347 and D-348.
Cbl-mediated ubiquitination, in response to high levels of Egfr ligand spi, is impaired resulting in reduced interaction with Graf and thus decreased GEEC-mediated endocytosis and degradation. Weak interaction with EGFRAP; when associated with F-1095; F-1204; F-1218; F-1246; F-1310; F-1342. Very weak interaction with EGFRAP; when associated with F-1095; F-1204; F-1218; F-1246; F-1310; F-1342 and 1405-F-F-1406.
Decreased interaction with EGFRAP; when associated with F-1357.
Forms dimers in presence of spitz. Forms weak dimers in the absence of spitz.
In dim-arm; Does not form dimers even in the presence of Spitz; when associated with E-341; A-342; D-344; E-346 and D-348.
In dim-arm; Does not form dimers even in the presence of spitz; when associated with A-342; D-344; E-346; A-347 and D-348.
In dim-arm; Does not form dimers even in the presence of spitz; when associated with E-341; A-342; D-344; A-347 and D-348.
In dim-arm; Does not form dimers even in the presence of spitz; when associated with E-341; A-342; D-344; E-346 and A-347.
In dim-arm; Does not form dimers even in the presence of spitz; when associated with E-341; D-344; E-346; A-347 and D-348.
In tether; No effect on binding to spitz; when associated with A-646 and A-649.
In tether; No effect on binding to spitz; when associated with A-646 and A-658.
In tether; No effect on binding to spitz; when associated with A-649 and A-658.
Increased binding to spitz; when associated with A-101; A-358 and S-369.
Increased binding to spitz; when associated with A-131; A-358 and S-369.
No effect on interaction with EGFRAP. Decreased interaction with EGFRAP; when associated with 1405-F-F-1406. Very weak interaction with EGFRAP; when associated with F-1095; F-1204; F-1218; F-1246; F-1271; F-1310.
Reduced dissociation and increased binding to spitz; when associated with A-358. Increased binding to spitz; when associated with A-101; A-131 and A-358.
Reduced dissociation and increased binding to spitz; when associated with S-369. Increased binding to spitz; when associated with A-101; A-131 and S-369.
Weak interaction with EGFRAP; when associated with F-1095; F-1204; F-1218; F-1246; F-1271; F-1342. Very weak interaction with EGFRAP; when associated with F-1095; F-1204; F-1218; F-1246; F-1271; F-1342 and 1405-F-F-1406.
Weak interaction with EGFRAP; when associated with F-1095; F-1204; F-1218; F-1271; F-1310; F-1342. Very weak interaction with EGFRAP; when associated with F-1095; F-1204; F-1218; F-1271; F-1310; F-1342 and 1405-F-F-1406.
Weak interaction with EGFRAP; when associated with F-1095; F-1204; F-1246; F-1271; F-1310; F-1342. Very weak interaction with EGFRAP; when associated with F-1095; F-1204; F-1246; F-1271; F-1310; F-1342 and 1405-F-F-1406.
Weak interaction with EGFRAP; when associated with F-1095; F-1218; F-1246; F-1271; F-1310; F-1342. Very weak interaction with EGFRAP; when associated with F-1095; F-1218; F-1246; F-1271; F-1310; F-1342 and 1405-F-F-1406.
Weak interaction with EGFRAP; when associated with F-1204; F-1218; F-1246; F-1271; F-1310; F-1342. Very weak interaction with EGFRAP; when associated with F-1204; F-1218; F-1246; F-1271; F-1310; F-1342 and 1405-F-F-1406.
Abolished phosphorylation by Cdk7, leading to increased ubiquitination by the DCX(DCAF12) complex.
Increased activity and nuclear localization and decreased sensitivity to Hpo/Wts-mediated inhibition; when associated with A-227.
Increased activity and nuclear localization and decreased sensitivity to Hpo/Wts-mediated inhibition; when associated with A-88.
Increased activity and nuclear localization, decreased sensitivity to Hpo/Wts-mediated inhibition, loss of interaction with 14-3-3epsilon and 14-3-3zeta.
Phosphomimetic mutant; decreased ubiquitination by the DCX(DCAF12) complex.
ArfGAP with SH3 domain, ANK repeat and PH domain-containing protein
H/ACA ribonucleoprotein complex subunit 2-like protein
Does not affect maturation of ninaE or Rh3. Does not cause accumulation of membranes at the base of the rhabdomeres or retinal degeneration.
Impairs maturation of ninaE and Rh3. Causes accumulation of membranes at the base of the rhabdomeres and retinal degeneration. Abolishes interaction with Rich. Alters direction of bristle growth and produces aberrations in the circumferential ridges.
Produces short bristles but does not alter the direction of their growth.
Coiled-coil domain-containing protein 130 homolog
Eukaryotic translation initiation factor 3 subunit G-1
In isoform I, isoform H, isoform L and isoform K.
Does not affect phosphorylation by Hipk.
Signal recognition particle SRP72 subunit RNA-binding
Succinate dehydrogenase assembly factor 4, mitochondrial
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase S
DNA-directed RNA polymerase RBP11-like dimerisation
Probable DNA-directed RNA polymerases I and III subunit RPAC2
Sodium/potassium-transporting ATPase subunit beta-1
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Tetratricopeptide repeat protein 36 homolog
Pre-rRNA-processing protein Ipi1 N-terminal
Probable DNA replication complex GINS protein PSF2
In 8B12; death primarily during embryogenesis and early larval stages with no obvious cuticle patterning defects.
30 X 2 AA approximate tandem repeats of G-[TN]
In strain: Berkeley, L18, Oregon-R, SP1 and U79.
Regulates the rhythm of species-specific courtship song
Broad-complex core protein isoforms 1/2/3/4/5
Results in age-dependent locomotor defects and neurodegeneration.
Reduces ability to repress transposon levels. Unable to rescue spermatogenesis defects in null mutants. Rescues germ stem cells defects in null mutants.
Putative 1-phosphatidylinositol 3-phosphate 5-kinase
Adenosine 3'-phospho 5'-phosphosulfate transporter 2
Elongation factor 1 beta central acidic region eukaryote
Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange
In strain: Zim-F-S18, Zim-S-H32 and Zim-S-S2.
Biogenesis of lysosome-related organelles complex 1 subunit 1
16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal
RNase L inhibitor RLI-like possible metal-binding
Eukaryotic translation initiation factor 3 subunit F-1
FHF complex subunit HOOK-interacting protein C-terminal
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8
Disrupts the SH2 domain. Does not affect binding to Dab.
Disrupts the SH3 domain. Abolishes binding to Dab; when associated with L-49.
In E(sev)2B mutant; ommatidial cell development obstruction.
In Su(sevs11)R1 mutant; ommatidial cell development obstruction.
Inactivates the SH3 domain. Abolishes binding to Dab; when associated with R-199.
Increases the stability of the SH3 1 domain.
Gamma-aminobutyric acid receptor alpha-like
Post-GPI attachment to proteins factor 3
Queuine tRNA-ribosyltransferase catalytic subunit
RNA binding; important for wobble base 34 recognition
Embryonic lethal and displays defects in primary tracheal branching and Malpighian morphogenesis. Displays abnormal splicing of zygotic transcripts resulting in qualitative (intron retention) as well as quantitative (transcript abundance) changes in gene expression. Tracheal defects are likely due, at least in part, to the mis-splicing of bnl transcripts. Embryonic Malpighian tubules are shortened and round.
Fand1; a large subset of zygotic but not maternally encoded pre-mRNAs, including the kuk transcript, display splicing defects. Consequently, maternally controlled oogenesis, such as primordial germ-cell formation and syncytial nuclear divisions, appear normal but during zygotically controlled blastoderm cellularization the cortical nuclei fail to elongate and become mislocalized. Reduced protein levels of ISY1/CG9667 but no effect on Prp19.
Fand2; embryos display significant splicing defects in the small zygotic kuk transcript whereas there is no effect on splicing of the large maternal kuk transcript. Reduced protein levels of ISY1/CG9667 but no effect on Prp19.
H124; embryonic lethal and displays defects in primary tracheal branching. Tracheal defects are likely due at least in part, to the mis-splicing of bnl transcripts. Earlier developmental processes, such as gastrulation and germband retraction are unaffected.
Calcium-activated potassium channel slowpoke
In isoform 2, isoform 3, isoform 5, isoform 6 and isoform M.
In isoform 5, isoform C, isoform H, isoform O, isoform P and isoform Q.
In isoform 6, isoform E, isoform P and isoform Q.
In isoform A, isoform D, isoform E, isoform F, isoform H, isoform M and isoform Q.
Abolishes activity; no effect on interaction with comm.
Putative polypeptide N-acetylgalactosaminyltransferase 13
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Probable G-protein coupled receptor Mth-like 11
N6-adenosine-methyltransferase MT-A70-like protein
Positively charged region required for RNA-binding
Severe lethality; when associated with A-413.
Severe lethality; when associated with A-416.
Abolishes binding to CBX5; when associated with A-30.
Abolishes binding to CBX5; when associated with or without A-130. Fails to rescue dominant defects in white reporter silencing produced by the piwi2 mutation.
Abolishes binding to piRNAs. Reduces localization to the nucleus. Does not affect chromatin binding. Affects fertility and ovary morphology.
Confers RNAi insensitivity; when associated with G-54.
Confers RNAi insensitivity; when associated with P-67.
Does not affect nuclear localization, repression activity of soma- and germline-specific transposable elements, fertility and piRNA loading; when associated with or without A-614.
Does not affect nuclear localization, repression activity of soma- and germline-specific transposable elements, fertility and piRNA loading; when associated with or without A-685.
Highly significant decrease in binding to papi.
Largely prevents nuclear accumulation. Affects repression activity of soma- and germline-specific transposable elements and fertility.
No significant effect on binding to papi.
In strain: MEL02, ZBMEL84, ZBMEL145, ZBMEL157, ZBMEL186, ZBMEL191, ZBMEL229, ZBMEL377, ZBMEL384 and ZBMEL398.
In strain: ZBMEL84, ZBMEL384 and ZBMEL398.
Ubiquitin-like modifier-activating enzyme 5
cAMP-specific 3',5'-cyclic phosphodiesterase
cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F
cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I
cAMP-specific 3',5'-cyclic phosphodiesterase, isoforms N/G
In strain: MB01a, MB08b, MB29b, MB36a, MB45b, MB47a, MB48b and MB52b and MB80b.
In strain: MB08b, MB15b, MB25a, MB29b, MB33a, MB34a, MB36a, MB39b, MB45b, MB46b, MB47a, MB48b, MB52b, MB58b, MB63a and MB80b.
In strain: MB08b, MB29b, MB36a, MB40b, MB47a, MB48b, MB52b and MB58b.
In strain: MB08b, MB29b, MB40b, MB45b, MB47a, MB48b, MB52b and MB80b.
In strain: MB13a, MB15b, MB25a, MB34a, MB37a and MB63a.
Chromosome transmission fidelity protein 18 homolog
Probable multidrug resistance-associated protein lethal(2)03659
Dolichyl-phosphate beta-glucosyltransferase
Fails to rescue glycosylation and growth phenotypes in yeast.
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Superoxide dismutase [Mn], mitochondrial
Decreased specific activity to L-DOPA and 5-HTP. Decreased ligand binding affinity.
Decreased specific activity to L-DOPA. Increased specific activity to 5-HTP. Decreased ligand binding affinity.
Enzymatic shift from L-dopa decarboxylation of to L-Dopa decarboxylation-oxidative deamination.
In allele Ddc-R6, allele Ddc-R9, allele Ddc-R16, allele Ddc-R20, allele Ddc-R25 and allele Ddc-R30.
Increased specific activity to L-DOPA and 5-HTP. Decreased ligand binding affinity.
Sulfatase-modifying factor enzyme domain-containing protein
Decreased aminoacylation, increased misacylation of non-cognate Tyr, increased amino acid misincorporation, ommatidia defects, neurodegeneration, impaired locomotive performance, reduced lifespan, smaller organ size due to reduced cell proliferation and increased ER stress. Similar but stronger phenotypes except that smaller organ size is due primarily to apoptosis; when associated with 'W-158' in beta subunit.
Phenylalanine--tRNA ligase alpha subunit
TATA element modulatory factor 1 TATA binding
Acidic leucine-rich nuclear phosphoprotein 32 family member A
ATP-dependent RNA helicase SUV3 homolog, mitochondrial
In BPL_1D, BPL_2B, BPL_3E, BPL_3F, BPL_5A, BPL_5D, BPL_5F, BPL_6D, BPL_6E, BPL_7F, BPL_8A, BPL_8C, BPL_9H, BPL_10D, BPL_10G, BPL_11D, BPL_12B, BPL_13A, BPL_13F, Florida1Slow and Paris.
In strain: AfricaFast, AfricaSlow, BPL_10A, BPL_10C, BPL_10D, BPL_10E, BPL_10G, BPL_10H, BPL_11B, BPL_11C, BPL_11D, BPL_11E, BPL_11F, BPL_11G, BPL_11H, BPL_12A, BPL_12B, BPL_12C, BPL_12F, BPL_13A, BPL_13B, BPL_13C, BPL_13D, BPL_13F, BPL_1A, BPL_1B, BPL_1C, BPL_1D, BPL_1E, BPL_1F, BPL_1G, BPL_1H, BPL_2A, BPL_2B, BPL_2C, BPL_2D, BPL_2E, BPL_2F, BPL_2G, BPL_2H, BPL_3A, BPL_3B, BPL_3C, BPL_3D, BPL_3E, BPL_3F, BPL_3G, BPL_3H, BPL_4A, BPL_4B, BPL_4C, BPL_4E, BPL_4G, BPL_5A, BPL_5B, BPL_5D, BPL_5E, BPL_5F, BPL_5G, BPL_5H, BPL_6A, BPL_6B, BPL_6D, BPL_6E, BPL_6F, BPL_6H, BPL_7A, BPL_7B, BPL_7C, BPL_7E, BPL_7F, BPL_7G, BPL_7H, BPL_8A, BPL_8B, BPL_8C, BPL_8D, BPL_8E, BPL_8F, BPL_8G, BPL_8H, BPL_9A, BPL_9B, BPL_9C, BPL_9D, BPL_9F, BPL_9H, Florida1Slow, Florida2Slow, FloridaFast, FrenchFast, FrenchSlow, JapanFast, JapanSlow, Paris and WashingtonFast.
In strain: AfricaFast, BPL_10C, BPL_10D, BPL_10E, BPL_10G, BPL_11B, BPL_11C, BPL_11D, BPL_11E, BPL_11F, BPL_11G, BPL_11H, BPL_12A, BPL_12B, BPL_12C, BPL_13A, BPL_13D, BPL_13F, BPL_1A, BPL_1B, BPL_1D, BPL_1G, BPL_2A, BPL_2B, BPL_2C, BPL_2D, BPL_2E, BPL_2G, BPL_2H, BPL_3A, BPL_3B, BPL_3C, BPL_3D, BPL_3E, BPL_3F, BPL_4A, BPL_4C, BPL_4E, BPL_4G, BPL_5A, BPL_5D, BPL_5F, BPL_5G, BPL_5H, BPL_6A, BPL_6B, BPL_6D, BPL_6E, BPL_6F, BPL_6H, BPL_7C, BPL_7E, BPL_7F, BPL_8A, BPL_8C, BPL_8D, BPL_8E, BPL_8F, BPL_9A, BPL_9C, BPL_9F, BPL_9H, Florida1Slow, FloridaFast, JapanSlow, Oregon-R, Paris and WashingtonFast.
In strain: AfricaFast, BPL_10C, BPL_10D, BPL_10E, BPL_10G, BPL_11B, BPL_11D, BPL_11F, BPL_11G, BPL_11H, BPL_12A, BPL_12C, BPL_13A, BPL_13D, BPL_13F, BPL_1A, BPL_1B, BPL_1G, BPL_2A, BPL_2B, BPL_2C, BPL_2D, BPL_2E, BPL_2G, BPL_2H, BPL_3A, BPL_3C, BPL_3D, BPL_3E, BPL_3F, BPL_4A, BPL_4C, BPL_4E, BPL_4G, BPL_5A, BPL_5B, BPL_5D, BPL_5F, BPL_5G, BPL_5H, BPL_6A, BPL_6B, BPL_6D, BPL_6F, BPL_6H, BPL_7C, BPL_7E, BPL_7F, BPL_7G, BPL_8A, BPL_8C, BPL_8D, BPL_8E, BPL_9A, BPL_9C, BPL_9F, BPL_9H, Florida1Slow, Florida2Slow, FloridaFast, Paris and WashingtonFast.
In strain: AfricaFast, BPL_1A, BPL_1B, BPL_1D, BPL_1G, BPL_2A, BPL_2B, BPL_2C, BPL_2D, BPL_2E, BPL_2G, BPL_2H, BPL_3B, BPL_3C, BPL_3D, BPL_3E, BPL_3F, BPL_4A, BPL_4C, BPL_4E, BPL_4G, BPL_5A, BPL_5D, BPL_5F, BPL_5G, BPL_5H, BPL_6A, BPL_6B, BPL_6D, BPL_6E, BPL_6F, BPL_6H, BPL_7C, BPL_7E, BPL_7F, BPL_8A, BPL_8C, BPL_8D, BPL_8E, BPL_8F, BPL_9A, BPL_9C, BPL_9F, BPL_9H, BPL_10C, BPL_10D, BPL_10E, BPL_10G, BPL_11B, BPL_11C, BPL_11D, BPL_11E, BPL_11F, BPL_11G, BPL_11H, BPL_12A, BPL_12B, BPL_12C, BPL_13A, BPL_13D, BPL_13F, FloridaFast, Florida1Slow, Paris and WashingtonFast.
In strain: AfricaSlow, AfricaFast, FloridaFast, Florida1Slow, Florida2Slow, FrenchSlow, JapanSlow, Paris and WashingtonFast.
In strain: BPL_10C, BPL_10D, BPL_10E, BPL_10G, BPL_10H, BPL_11B, BPL_11C, BPL_11D, BPL_11F, BPL_11G, BPL_11H, BPL_12A, BPL_12B, BPL_12C, BPL_13A, BPL_13C, BPL_13D, BPL_13F, BPL_1A, BPL_1B, BPL_1C, BPL_1D, BPL_1E, BPL_1G, BPL_1H, BPL_2A, BPL_2B, BPL_2C, BPL_2D, BPL_2E, BPL_2G, BPL_2H, BPL_3A, BPL_3B, BPL_3C, BPL_3D, BPL_3E, BPL_3F, BPL_3G, BPL_3H, BPL_4A, BPL_4B, BPL_4C, BPL_4E, BPL_4G, BPL_5A, BPL_5D, BPL_5E, BPL_5F, BPL_5G, BPL_5H, BPL_6A, BPL_6B, BPL_6D, BPL_6E, BPL_6F, BPL_6H, BPL_7B, BPL_7C, BPL_7E, BPL_7F, BPL_7H, BPL_8A, BPL_8C, BPL_8D, BPL_8E, BPL_8F, BPL_8G, BPL_9A, BPL_9C, BPL_9F, BPL_9H, FrenchSlow and Paris.
In strain: BPL_1A, BPL_1G, BPL_2A, BPL_2G, BPL_2H, BPL_3C, BPL_4A, BPL_4C, BPL_4G, BPL_5H, BPL_6H, BPL_7C, BPL_10E, BPL_11C, BPL_11H, BPL_12A and WashingtonFast.
In strain: BPL_1D, BPL_2B, BPL_3E, BPL_3F, BPL_9H, BPL_10D, BPL_10G, BPL_11D, BPL_12B and BPL_13A.
In strain: BPL_1H, BPL_3H, BPL_4B, BPL_5E, BPL_7B, BPL_7H, BPL_8G, BPL_10H and BPL_13C.
In strain: BPL_6H, BPL_7C, BPL_11F and BPL_12A.
In strain: BPL_7A, BPL_9D, BPL_10A and BPL_11E.
Eukaryotic translation initiation factor 2 subunit 3
Polypeptide N-acetylgalactosaminyltransferase 1
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1
Glutathione S-transferase C-terminal domain-containing protein homolog
In DLis8.25.3; induces defects in nuclear migration.
In Lis1-23F2; induces lethality in second instar larvae.
Mediator of RNA polymerase II transcription subunit 27
GTPase-GDP dissociation stimulator vimar
RNA polymerase II transcriptional coactivator
Transcriptional coactivator p15 (PC4) C-terminal
In CJ101; larvae lethal. In egg chambers, follicle cells (FC) display abnormal localization of various apical, junctional and basolateral proteins, and loss of epithelial integrity. In follicle epithelium (FE) cells, the basal membrane proteins, trol, Lam and vkg display abnormal localization; accumulating on the apical side of the cell in addition to the normal basal accumulation. Expression of strat in the FE is reduced. In egg chambers, trol also shows abnormal apical localization at the posterior pole. Many FCs appear irregularly shaped at the poles, form multiple layers and are often found in the germline cluster. FCs on the lateral side however, appear normal.
Larvae lethal at the L2 stage. Adult flies display subtle defects in ommatidial organization.
Larvae lethal at the L2 stage. In photoreceptor cells, light-induced accumulation of newly synthesized ninaE (Rh1) post-Golgi vesicles leads to a reduction in membrane stack volume, and eventually, photoreceptor cell degeneration. Disruption of photoreceptor cell function is light- and age-dependent.
Probable methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
Complete loss of activity; when associated with A-67.
Complete loss of activity; when associated with A-74.
Reduced activation of SPR; when associated with A-202.
Abolishes tal-dependent cleavage and ubiquitination by Ubr3; when associated with G-3 and G-8.
Decreases but does not prevent tal-dependent cleavage. Abolishes tal-dependent cleavage; when associated with G-8. Abolishes tal-dependent cleavage and ubiquitination by Ubr3; when associated with G-8 and G-28.
In ovo-D1; dominant antimorphic mutation leading to the creation of a new upstream initiation codon in isoform D. Heterozygous females are sterile. The male germline is unaffected.
In ovo-D2; dominant antimorphic mutation leading to the creation of a new upstream initiation codon in isoform D. Heterozygous females are sterile. The male germline is unaffected.
In ovo-D3; dominant antimorphic mutation leading to the creation of a new upstream initiation codon in isoform D. Heterozygous females are sterile. The male germline is unaffected.
No effect on tal-dependent cleavage. Abolishes tal-dependent cleavage; when associated with G-3. Abolishes tal-dependent cleavage and ubiquitination by Ubr3; when associated with G-3 and G-28.
Required for Ubr3 binding and tal-dependent proteolytic processing
Ribosomal RNA methyltransferase SPB1-like C-terminal
In allele eIF4AIII-19; homozygous oocytes are non-viable.
Aryl hydrocarbon receptor nuclear translocator homolog
DDB1- and CUL4-associated factor 12 homolog
In sing-22; myoblast fusion is abolished and consequently multinucleated myofibers fail to form during embryonic muscle development.
In sing-23; myoblast fusion is abolished and consequently multinucleated myofibers fail to form during embryonic muscle development.
In sing-27; myoblast fusion is abolished and consequently multinucleated myofibers fail to form during embryonic muscle development.
Impaired ability to inhibit the Wnt signaling pathway.
Palmitoleoyl-protein carboxylesterase NOTUM
Mediator of RNA polymerase II transcription subunit 15
Probable small nuclear ribonucleoprotein E
Transcription initiation factor IIA gamma subunit C-terminal
Transcription initiation factor IIA gamma subunit N-terminal
Transcription initiation factor IIA subunit 2-2
Enhances interaction with mbt. Coexpression with mbt slightly reduced the substrate phosphorylation ability of mbt.
NADPH:adrenodoxin oxidoreductase, mitochondrial
DNA-directed RNA polymerases I, II, and III subunit RPABC5
Actin interacting protein 3-like C-terminal
Coiled-coil domain-containing protein CG32809
Minor reduction of in vitro phosphorylation by CkIIalpha; when associated with A-327 and A-332.
Minor reduction of in vitro phosphorylation by CkIIalpha; when associated with A-327 and A-333.
Minor reduction of in vitro phosphorylation by CkIIalpha; when associated with A-332 and A-333.
Strongly reduced in vitro phosphorylation by CkIIalpha; when associated with A-288 and A-290.
Strongly reduced in vitro phosphorylation by CkIIalpha; when associated with A-288 and A-292.
Strongly reduced in vitro phosphorylation by CkIIalpha; when associated with A-290 and A-292.
C-terminal domain (CTD); 32 X 7 AA approximate tandem repeats of Y-[ST]-P-[STNVAPGN]-[STGMA]-[PSTR]-[SNAGCQKTLRIMH]
DNA-directed RNA polymerase II subunit RPB1
Mediator of RNA polymerase II transcription subunit 19
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
NPC intracellular cholesterol transporter 2 homolog a
NIF system FeS cluster assembly NifU N-terminal
Nuclear receptor-binding protein homolog
DNA replication complex GINS protein SLD5 C-terminal
Probable glucosamine 6-phosphate N-acetyltransferase
Nuclear distribution protein nudE homolog
Coenzyme Q-binding protein COQ10, mitochondrial
Transient receptor potential-gamma protein
E3 ubiquitin-protein ligase RNF220 middle
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)
Transcription elongation factor 1 homolog
Dual specificity mitogen-activated protein kinase kinase hemipterous
Small nuclear ribonucleoprotein Prp3 C-terminal
Rab proteins geranylgeranyltransferase component A
No effect on its function in maintaining muscle integrity.
Required for maintaining muscle integrity
Succinate dehydrogenase assembly factor 3, mitochondrial
Mutant flies show an accumulation of reactive oxygen species, mitochondrial dysfunction and neurodegeneration.
Mitochondrial import inner membrane translocase subunit Tim22
Ubiquitin-conjugating enzyme E2Q-like protein CG4502
Abolishes in vitro phosphorylation by LIMK1. Partial rescue of both the defective neuroblast proliferation and defective axon growth seen in null mutants.
Cofilin/actin-depolymerizing factor homolog
Defective distal orientation of wing hairs and incorrect localization of the planar cell polarity proteins fz and stan/fmi; when associated with 139-AAALA-143.
Defective distal orientation of wing hairs and incorrect localization of the planar cell polarity proteins fz and stan/fmi; when associated with Q-27.
No rescue of the defective neuroblast proliferation seen in null mutants but partial rescue of the defective axon growth.
Conserved oligomeric Golgi complex subunit 8
Guanine nucleotide-binding protein subunit alpha homolog
26S proteasome non-ATPase regulatory subunit 5
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
Greatly reduces sev binding and sev signaling.
Exonuclease 3'-5' domain-containing protein 2
MICOS complex subunit MIC13 homolog QIL1
Abolishes adenylyltransferase and phosphodiesterase activities.
Disrupts homodimerization, leading to increased adenylyltransferase activity and reduced phosphodiesterase activity.
Important for autoinhibition of adenylyltransferase activity
Promotes adenylyltransferase activity. Overexpression is lethal in a Fic null background.
Solute carrier family 35 member E1 homolog
UV radiation resistance-associated gene protein
Probable ATP-dependent RNA helicase DDX55 homolog
Circadian locomoter output cycles protein kaput
Fat-like cadherin-related tumor suppressor homolog
Abolishes enzyme activity but retains PGN-binding.
Clathrin/coatomer adaptor adaptin-like N-terminal
Coatomer gamma subunit appendage Ig-like subdomain
Mild reduction in interaction with eIF4E1. Complete loss of interaction with eIF4E1; when associated with A-327 and A-364.
Mild reduction in interaction with eIF4E1. Complete loss of interaction with eIF4E1; when associated with A-327 and A-368.
Reduction in interaction with eIF4E1. Strong reduction in interaction with eIF4E1; when associated with A-327.
Strong reduction in interaction with eIF4E1. Strong reduction in interaction with eIF4E1; when associated with A-332 and A-348. Complete loss of interaction with eIF4E1; when associated with A-364 and A-368.
Loss of catalytic activity. Reduced nuclear size in larval salivary glands.
Serine/threonine-protein kinase haspin homolog
LEM domain-containing protein Bocksbeutel
Pre-rRNA-processing protein TSR1 homolog
In strain: ZIM5C, ZIM10C, ZIM16C, ZIM18C, ZIM28C, ZIM30C, ZIM34C and ZIM53C.
Involved in binding to (N(6)-methyladenosine) DNA
Tectonin beta-propeller repeat-containing protein
Dolichol-phosphate mannosyltransferase subunit 1
Impaired cell growth, survival of postmitotic ommatidial cells and differentiation into R8 photoreceptors. Normal eye morphology; when associated with V-12.
Mild rough eye phenotype; when associated with V-12.
Rough eyes characterized by the presence of additional R7 photoreceptor cells. Normal survival of postmitotic ommatidial cells but differentiation into photoreceptor cells is limited to R8 cells. Less severe Rough eye phenotype; when associated with E-38. Normal eyes; when associated with C-40.
Ancestral coatomer element 1 Sec16/Sec31
Gram-negative bacteria-binding protein 3
In strain: Netherlands line N02 and Netherlands line N30.
In strain: Netherlands line N02, Netherlands line N07, Netherlands line N17 and Netherlands line N30.
Does not affect localization to synapse.
Open rectifier potassium channel protein 1
In isoform 2a, isoform 2b and isoform 2c.
Phosphomannose isomerase type I catalytic
Phosphomannose isomerase type I helical insertion
Gamma-aminobutyric acid receptor subunit beta-like
DNA repair protein complementing XP-C cells homolog
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein
In allele Z1091; wing expansion defects, failure to sclerotize cuticle.
In allele Z1140; wing expansion defects.
In allele Z5569; wing expansion defects, failure to sclerotize cuticle.
Transient receptor potential channel pyrexia
Supporter of activation of yellow protein
Putative inner dynein arm light chain, axonemal
UDP-xylose and UDP-N-acetylglucosamine transporter
Adults display adherent transition zone (TZ) assembly and cilia are almost completely lost in auditory neurons. Consequently, adults display defects associated with ciliary dysfunction and disorganization, such as uncoordination, inability to stand, and severely deficient in touch and hearing. In spermatocytes, ciliary axonemes extend aberrantly and the basal body and plasma membrane separate at later stages of spermatogenesis.
Viable but displays adherent transition zone (TZ) assembly in sensory neurons and spermatocytes. Consequently, adults display defects associated with ciliary dysfunction and disorganization, such as severe uncoordination and axonemal defects and dispersed nuclei in the testes. Cilia are essentially absent in antennal chordotonal organs, transition zones are disorganized and microtubules fail to elongate.
Cytosolic Fe-S cluster assembly factor Nubp2 homolog
Glyceraldehyde-3-phosphate dehydrogenase 1
In strain: HFL23, HFL5, VT10, VT6 and HFL2.
DNA polymerase subunit gamma-2, mitochondrial
Loss of mitochondrial DNA which disrupts mitochondrial morphology; larval brains are smaller due to defective cell proliferation leading to death at the pupal stage.
In allele WO49; impedes segmental patterning of the embryo and the heat shock response.
Protein downstream neighbor of son homolog
Abolishes activity and autophosphorylation. Fails to recruit park to mitochondria.
Loss of kinase activity and impaired recruitment of park to mitochondria. Loss of kinase activity resulting in impaired mitochondrial integrity and function; when associated with R-337 and A-501.
Loss of kinase activity resulting in impaired mitochondrial integrity and function; when associated with A-479 and A-501.
Loss of kinase activity. Loss of kinase activity resulting in impaired mitochondrial integrity and function; when associated with R-337 and A-479.
No effect on activity and autophosphorylation.
Phosphomimetic mutant; no effect on activity and promotes translocation of park to mitochondria.
Serine/threonine-protein kinase Pink1, mitochondrial
Succinate dehydrogenase assembly factor 2-A, mitochondrial
ER membrane protein complex subunit 8/9 homolog
In strain: NVIII-1, NVIII-2, NVIII-5, NVIII-9, NVIII-18, NVIII-22, NVIII-24, NVIII-41, NVIII-42, NVIII-46, NVIII-m11, NVIII-m12, NVIII-m13, NVIII-m15 and NVIII-m19.
In strain: NVIII-5, NVIII-9, NVIII-46 and NVIII-41.
In psh1 and psh4; immune response defective. Reduced levels of Drs following immune challenge with fungal or bacterial proteases.
Signal recognition particle 9 kDa protein
Proteasomal ubiquitin receptor ADRM1 homolog
Inhibits binding to Cdc42; when associated with L-19.
Inhibits binding to Cdc42; when associated with L-22.
Strongly reduces autophosphorylation and substrate phosphorylation.
Calcium ion selectivity and permeability
Homolog of P-1673 variant in human. Does not rescue cac-F and cac-J lethal phenotypes. Highly increases amplitude on the synaptic transmission. Induces severe neurodegeneration in both photoreceptor cell bodies and terminals.
Homolog of Q-1664 variant in human. Partially rescues the cac-F and cac-J lethal phenotypes. Does not rescue the loss of synaptic transmission cac-F and cac-J variants. No effect on photoreceptor morphology.
In cac-F; lethal at the larval stage 3; loss of synaptic transmission.
In cac-J; lethal at an embryonic stage; loss of synaptic transmission.
In cac-S; exhibits defects in the patterning of courtship lovesong and a subtle abnormality in visual physiology.
Voltage-dependent calcium channel type A subunit alpha-1
In DMAD(Del-CXXC); flies are viable and fertile.
In DMAD-CD(mut); abolishes ability to demethylate m6ADNA.
Abolishes phosphorylation by Pink1 and reduces enzyme activity. Mitochondrial morphology and function is relatively normal however, expression in TH-neurons results in impaired flying ability, impaired dopamine release and an age-dependent loss of DA neurons, spherical clustering of mitochondria in DA neurons and disturbed mitochondrial transport. Able to rescue all mitochondrial and behavioral defects caused by the loss of Pink1. Partially rescues mitochondrial morphology and abnormal wing posture caused by loss of park. No effect on translocation to mitochondria.
Abolishes self-ubiquitination resulting in decreased E3 ligase activity.
Fails to rescue mitochondrial abnormalities and increases apoptosis in null mutants.
Loss of monoubiquitination and polyubiquitination of porin.
Phosphomimetic mutant with increased enzyme activity. Lethal when ubiquitously expressed. Constitutive phosphorylation results in impaired motor activity and fragmented mitochondria, likely due to reduced levels of the outer mitochondrial membrane proteins Marf and Miro. Expression in TH-neurons results in impaired flying ability, impaired dopamine release and substantial loss of DA neurons in very young adults (5-day old), single large mitochondria in each DA neuronal cell and loss of mitochondrial transport. Able to rescue reduced adult survival caused by loss of Pink1.
Reduced mitochondrial localization in the presence of Pink1. Reduced rescue of mitochondrial defects when expressed in null mutants.
Abolishes enzyme activity but no effect on protein folding nor secretion; when associated with A-442.
Abolishes enzyme activity but no effect on protein folding nor secretion; when associated with A-443.
GDP-fucose protein O-fucosyltransferase 2
Fork head domain-containing protein crocodile
tRNA (cytosine(34)-C(5))-methyltransferase
WW domain-containing adapter protein with coiled-coil homolog
Protein inscuteable homologue C-terminal
Putative ATP synthase subunit f, mitochondrial
Transcription elongation factor B polypeptide 3
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Nuclear respiratory factor 1 NLS/DNA-binding dimerisation
Ubiquitin/SUMO-activating enzyme ubiquitin-like
Conserved oligomeric Golgi complex subunit 4
In J55; embryonic lethality with excessively elongated tracheal tubes.
In K104; embryonic lethality with excessively elongated tracheal tubes.
In K93; embryonic lethality with excessively elongated tracheal tubes.
In L224; embryonic lethality with excessively elongated tracheal tubes.
Protein kinase domain-containing protein
Minimal N-terminal region required for miRNA-mediated silencing
Not required for interaction with AGO1 or miRNAs or for localization to P-bodies but necessary for miRNA-mediated silencing and for interaction with pAbp
Not required for interaction with AGO1 or miRNAs or for localization to P-bodies but necessary for miRNA-mediated silencing, dissociation from AGO1 and miRNAs and interaction with pAbp
Tubulin polymerization-promoting protein homolog
In CEP290-1; in olfactory and auditory neurons, transition zones (TZ) fail to form leading to the disassociation of the basal bodies from plasma membrane at later stages cliliogenesis, abnormal elongation of the axoneme and consequently complete loss of cilia. As a consequence, adults are uncoordinated and have severe defects in touch and hearing. In testes, flagellar axonemes are almost completely lost and sperm cyst elongation is severely defective. As a consequence, mature sperms do not develop and so males are completely infertile.
In CEP290-C; no effect on cilium basal body localization.
In CEP290-M; abolishes cilium basal body localization; when associated with 1385-G--E-1978.
In CEP290-N+M; no effect on cilium basal body localization. In CEP290-M; abolishes cilium basal body localization; when associated with 1-M--E-650.
In CEP290-N; no effect on cilium basal body localization however expression in more restricted within the transition zone of auditory cilia. When overexpressed in CEP290-1 mutants, rescues defects in ciliogenesis, basal body docking, transition zone (TZ) assembly, and recruitment of DZP1 and Mks1 to the TZ. It does not rescue uncoordination.
In olfactory and auditory neurons, transition zones (TZ) fail to form, ciliary axonemes are lost and DZIP1 expression is significantly reduced resulting in uncoordination and severe defects in touch and hearing. No effect on connection between the basal bodies and plasma membrane. Mild defects in spermatid development and male fertility. In spermatocyte cilia there is no significant reduction in DZIP1 expression.
Necessary and sufficient for function in ciliogenesis, transition zone (TZ) assembly, and recruitment of DZP1 and Mks1 to the TZ. Also required for subcellular localization to the cilium basal body
Results in motor defects including crossed legs and inability to stand or hold wings erect. In sensory neurons, results in failure to form a transition zone. In cilia, shows severe proprioception defects including defective mechanoreceptor current (MRC) but normal transepithelial potential (TEP). In germ cells, results in defective transition zone assembly and ciliary cap structure; the defects include increased distance between microtubules (MT) and between MT and membrane and it is associated with longer cilium basal body. This leads to ultrastructural axoneme defects without compromising the attachment of spermatocyte centrioles to the membrane.
Eukaryotic translation initiation factor 3 subunit I
Differentially expressed in FDCP 8 homolog
Breast carcinoma-amplified sequence 3 homolog
Decreases sleep latency; when associated with S-301.
Gamma-aminobutyric acid receptor subunit beta
In RNA edited version; does not alter GABA receptor activity; retains inhibition by picrotoxin; shows resistance to picrotoxinin; when associated with S-301.
Reduces in-current for inward flow of chloride ions, results in slower and incomplete desensitization which ultimately increases single channel open durations. Resistant to picrotoxinin (PTX) and cyclodiene dieldrin insecticides. Retains partial sensitivity to TBPS and lindane. Decreases sleep latency, increases total sleep time and shows resistance to carbamazepine sleep-induced effects on sleep both by itself or when associated with I-360. Restores defective sleep in Nlg4 and Lztr1 mutants. Retains resistance to picrotoxinin; when associated with V-283.
Probable G-protein coupled receptor CG31760
Dual specificity mitogen-activated protein kinase kinase dSOR1
Calcium/calmodulin-dependent protein kinase type II alpha chain
Fails to interact with CASK, catalytically active and can autophosphorylate, when associated with S-306.
Fails to interact with CASK, catalytically active and can autophosphorylate, when associated with S-307.
Fails to interact with CASK, catalytically active but fails to autophosphorylate, when associated with A-306.
Fails to interact with CASK, catalytically active but fails to autophosphorylate, when associated with A-307.
Fails to interact with CASK, kinase inactive, when associated with D-306.
Fails to interact with CASK, kinase inactive, when associated with D-307.
Guanine nucleotide-binding protein subunit gamma-e
Ribosome-releasing factor 2, mitochondrial
Increased phosphatidic acid binding but no effect on phosphatidylinositol binding or transfer activity.
tRNA (guanine(26)-N(2))-dimethyltransferase
Pericentrin/AKAP-450 centrosomal targeting
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Impaired cap1 2'-O-ribose methylation, siRNA biogenesis and RISC complex assembly. Flies are viable with no visible phenotype. No effect on miRNA biogenesis.
Protein phosphatase 1 regulatory subunit 15A/B C-terminal
Proton-coupled amino acid transporter-like protein pathetic
Involved in binding clathrin heavy chain
Uncharacterized Golgi apparatus membrane protein-like protein CG5021
Origin recognition complex subunit 3 N-terminal
Origin recognition complex subunit 3 insertion
Origin recognition complex subunit 3 winged helix C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
LKB1 serine/threonine kinase interacting protein 1 N-terminal
In strain: LAMTO 13, LAMTO 37 and LAMTO 134.
In strain: LAMTO 3, LAMTO 4, LAMTO 12, LAMTO 18, LAMTO 19, LAMTO 21, LAMTO 31, LAMTO 35, LAMTO 101 and LAMTO 111.
In D57; induces head-like skeletal structures in the trunk.
In E9; induces head-like skeletal structures in the trunk.
Cleavage and polyadenylation specificity factor subunit 4
Reduces palmitoylation. Loss of palmitoylation; when associated with A-120 and A-147.
Reduces protein stability and palmitoylation. Loss of palmitoylation; when associated with A-120 and A-147.
tRNA-uridine aminocarboxypropyltransferase 2
Abolishes interaction with Nedd4, ubiquitination and internalization; when associated with A-221.
Abolishes interaction with Nedd4, ubiquitination and internalization; when associated with A-230.
Circadian clock-controlled protein daywake
In strain: Oregon-R, wi4, wi15, wi6, wi24, wi30, wi32 and wi33.
In strain: DI7, Draveil, Loua, Monty5, Tahiti, Texas, S30 and ZW141.
In strain: Loua, Monty5, P. bourg, Tahiti, Texas and S30.
Protein N-terminal glutamine amidohydrolase
Protein N-terminal glutamine amidohydrolase alpha beta roll
Vacuolar protein sorting-associated protein 8 homolog
Interferon-related developmental regulator C-terminal
Interferon-related developmental regulator N-terminal
Markedly reduced interaction with shark. In contrast to the wild-type, does not rescue the ability of macrophages to migrate to a wound when expressed in drpr mutants. Protein still undergoes tyrosine phosphorylation and rescues the defective phagocytosis caused by a loss of endogenous drpr.
Protein still undergoes tyrosine phosphorylation but fails to rescue the defective phagocytosis caused by a loss of endogenous drpr.
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 2
Eukaryotic translation initiation factor 5A
Transcription factor glial cells missing 2
Chromatin modification-related protein MEAF6
In Bwx; eyes are brown due to a reduction in red pigment production.
In Et87; 98% decrease in drosopterin (eye red pigment) levels and undetectable levels of xanthommatin (eye brown pigment).
In cf; 70% decrease in drosopterin (eye red pigment) levels, 36% decrease in xanthommatin (eye brown pigment) levels and severe defect of copulation success; when associated with E-589.
In cf; 70% decrease in drosopterin (eye red pigment) levels, 36% decrease in xanthommatin (eye brown pigment) levels and severe defect of copulation success; when associated with R-49.
In co2; normal eye color. Eyes are brown due to a reduction in red pigment production in a bw/brown 6 or T50 mutant background.
In crr; 89% decrease in drosopterin (eye red pigment) levels and 81% decrease in xanthommatin (eye brown pigment) levels.
In sat; 96% decrease in drosopterin (eye red pigment) levels and 21% decrease in xanthommatin (eye brown pigment) levels.
DNA recombination and repair protein Rad51-like C-terminal
Abolishes Monooxygenase activity and impairs axon guidance functions.
Transcription factor p53 C-terminal Drosophila
Results in a defective gastrulation with excessive ventralization showing very prominent ventral furrow, no anterior displacement of posterior cells and only a small headfold on the dorsal side of the embryo.
In car-1; irregular clustering of early endosomes; when associated with V-249.
In car-1; irregular clustering of early endosomes; when associated with V-26.
Vacuolar protein sorting-associated protein 33A
Involved in inner nuclear membrane localization
May be required for its role in BMP signaling
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
Incomplete processing of Acp26Aa and Semp1 in mated females.
Loss of cleavage of Acp26Aa and Acp36DE.
No processing of Acp26Aa in mated females and incomplete processing of Semp1.
COA8 family protein CG14806, mitochondrial
Steroidogenic acute regulatory protein-like
Embryonic salivary glands display irregularities that are consistent with potential migration defects, including subtle variations in lumenal diameter, bending/folding, and occasional branching of the lumen. No effect on muscle or hindgut morphology.
Signal recognition particle receptor subunit alpha homolog
C-1-tetrahydrofolate synthase, cytoplasmic
Methylenetetrahydrofolate dehydrogenase and cyclohydrolase
CCR4-NOT transcription complex subunit 10
In QW55; abnormal arrest in female meiosis.
In RH65; abnormal arrest in female meiosis.
Prevents degradation following egg activation.
Viable, male-fertile, female-sterile. Female embryos lack mitotic progression with terminal arrest at the first cleavage division.
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
O-(3'-phospho-DNA)-tyrosine intermediate
Ubiquinone biosynthesis protein COQ9, mitochondrial
Eukaryotic translation initiation factor 4E-binding protein
In d4E-BP(LL) mutant; increased interaction with eIF4E1; expression of this mutant in wing-imaginal disks causes a reduction of wing size, caused by a decrease in cell size and number.
Phosphomimetic mutant; does not affect interaction with free eIF4E1.
Strongly decreased interaction with eIF4E1.
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Cyclin-dependent kinases regulatory subunit
Intraflagellar transport protein 57 homolog
In eye imaginal disks, hh signaling is impaired resulting in delayed differentiation of photoreceptors in the morphogenetic furrow. In Johnston's organs, results in reduced auditory transduction. Often the filamentous structure of NompA at the apical junction of the neuronal cilium and antennal cuticle collapses into puncta resulting in the detachment of scolopidia from the hinge of the second and third antennal segment.
DNA-directed RNA polymerase II subunit RPB9
cAMP-dependent protein kinase catalytic subunit 1
In Sce33M2; induces extra sex combs due to derepression of Ubx homeotic gene and abolishes ability to ubiquitinate histone H2A.
14 X 3 AA repeats of A-A-Q (approximate)
In allele sim-J1-47; temperature sensitive embryonic midline axon phenotype.
Proton-coupled amino acid transporter-like protein CG1139
Chromodomain-helicase-DNA-binding protein 1
Activity-regulated cytoskeleton associated protein 2
Multiple C2 and transmembrane domain-containing protein
Thioredoxin-related transmembrane protein 2 homolog
Fork head domain transcription factor slp1
Transcription initiation factor TFIID subunit 8
Cytochrome c oxidase assembly factor 7 homolog
Elongation of very long chain fatty acids protein 6
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Putative tRNA pseudouridine synthase Pus10
Guanine nucleotide exchange factor MSS4 homolog
Histone-lysine N-methyltransferase SETD1
In G5; predominantly lethal at the pupal stage with low levels of late L3 larval lethality.
Abolishes propeptide cleavage and ability to cleave sog; when associated with A-516.
Abolishes propeptide cleavage and ability to cleave sog; when associated with A-519.
In tlr1-I678; Absent and/or mislocalized neuromuscular junctions with misrouted motor axons.
Chromatin-remodeling complex ATPase chain Iswi
Results in zinc-elicited currents with increased rise time and deactivation kinetics in Xenopus oocytes; when associated with F-296.
Results in zinc-elicited currents with increased rise time and deactivation kinetics in Xenopus oocytes; when associated with K-255.
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase I
Loss of binding with Gorab and thus abolishes subcellular localization of Gorab at the centriole. No effect on homodimerization or localization of Gorab to the Golgi. Partially rescues coordination defects and centriole loss in the null mutant.
No effect on binding with Gorab or homodimerization.
No effect on binding with Gorab or homodimerization. Rescues coordination defects and centriole loss in both interphase and mitotic cells of the null mutant.
Spindle assembly abnormal protein 6 homolog
Probable cleavage and polyadenylation specificity factor subunit 2
Lipid storage droplets surface-binding protein 2
Guanylate kinase/L-type calcium channel beta subunit
Guanine nucleotide-binding protein G(f) subunit alpha
Results in increased localization to mitochondria.
Results in neuronal terminal arborization defects and loss of neuroblasts.
Suppresses accumulation at the synapse, reduced fly viability and defective neuromuscular junction; when associated with K-320.
When overexpressed in the whole body or mesoderm, impairs development and reduces longevity. When overexpressed in neurons, impairs progressively neuronal functionality and morphology.
When overexpressed in the whole body, leads to motor deficits, progressive neuromuscular junction (NMJ) denervation and pre-synaptic build-up of mutant GlyRS ultimately causing lethality. Similar effects are shown when overexpressed in the mesoderm or neurons. Accumulates at the synapse. When overexpressed in neurons, impairs progressively neuronal functionality and morphology. Toxicity might be mediated by modulation of the plexin-semaphorin signaling. Suppresses accumulation at the synapse, reduced fly viability and defective neuromuscular junction; when associated with 97-A--F-163 DEL.
In strain: DI7, Loua, Monty5, Tahiti and ZW141.
Abolishes enzymatic activity; when associated with A-534.
Abolishes enzymatic activity; when associated with A-536.
Gastrulation defective protein 1 homolog
H/ACA ribonucleoprotein complex subunit 3
Double-stranded RNA-specific editase Adar
Results in a loss of odor-evoked response to acetic acid and a gain of response to butyric acid and 2-oxopentanoic acid; when associated with K-536 and L-538.
Results in a loss of odor-evoked response to acetic acid and a gain of response to butyric acid and 2-oxopentanoic acid; when associated with T-289 and K-536.
Results in a loss of odor-evoked response to acetic acid and a gain of response to butyric acid and 2-oxopentanoic acid; when associated with T-289 and L-538.
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Fibroblast growth factor receptor homolog 1
HEAT repeat-containing protein 1 homolog
tRNA(Met) cytidine acetyltransferase TmcA N-terminal
Conserved oligomeric Golgi complex subunit 3
In ncd(D); reduces motor velocity and shows abnormal chromosomal segregation.
Greatly reduced autoprocessing activity.
N-product is made but fails to undergo palmitoylation.
Large ribosomal subunit protein uL6 N-terminal
Peroxisomal multifunctional enzyme type 2
In isoform A, isoform B, isoform C and isoform H.
In isoform A, isoform C, isoform E and isoform G.
In isoform C, isoform F, isoform G and isoform H.
3-fold increase in sensitivity to cocaine inhibition of transport.
Pheromone-binding protein-related protein 6
Probable ribosome biogenesis protein RLP24
Increases the amount of synaptic boutons and microtubule loops when expressed presynaptically.
DNA-directed RNA polymerase II subunit Rpb4
Multiple inositol polyphosphate phosphatase 1
DNA-directed RNA polymerase III subunit RPC6
Abolishes binding with Rab6 and decreased binding with Sas-6.
Abolishes binding with Rab6. No effect on binding to Sas-6.
Decreased binding with Sas-6 and abolishes homodimerization. Loss of localization to the Golgi and centrosomes. Results in female sterility and loss of coordination.
Loss of localization to the Golgi and centrosomes. Results in female sterility and loss of coordination.
Loss of localization to the Golgi while retaining localization to the centrosomes.
Loss of localization to the Golgi while retaining localization to the centrosomes. No effect on binding with Sas-6.
Necessary for interaction with Sas-6 and essential for homodimerization
Necessary for localization to the centrosome
Loss of interaction with CG7546. Retains ubiquitin-protein ligase activity.
Loss of ubiquitination activity; when associated with A-253.
Loss of ubiquitination activity; when associated with A-256.
UbiA prenyltransferase domain-containing protein 1 homolog
Probable DNA mismatch repair protein Msh6
MMS19 nucleotide excision repair protein
Cleavage and polyadenylation specificity factor 73
Ragulator complex protein LAMTOR4 homolog
N-acetylcysteine; in Chorion peroxidase light chain
Adenine-nucleotide binding in RNA target
Guanine-nucleotide binding in RNA target
In Pum680; abolishes interaction with brat and translational repression activity but not RNA-binding activity.
Non-specific-nucleotide binding in RNA target
F-box-like/WD repeat-containing protein ebi
In ebi4; induces defects in R7 cell development in the eye.
In ebiCC1; induces ectopic S phases within the peripheral and central nervous system.
In ebiCC3; induces ectopic S phases within the peripheral and central nervous system.
SH3 domain-binding glutamic acid-rich protein homolog
Non-canonical poly(A) RNA polymerase protein Trf4-1
Kelch domain-containing protein 10 homolog
Partially rescues mtDNA levels and hatching rate in spoon null mutants. In larp-10A, loss of phosphorylation by Pink1; when associated with A-66; A-107; A-182; A-186; 219-A-A-221; A-1119 and 1510-A-A-1512.
Partially rescues mtDNA levels and hatching rate in spoon null mutants. In larp-10A, loss of phosphorylation by Pink1; when associated with A-66; A-107; A-182; A-186; 219-A-A-221; A-828 and A-1119.
Partially rescues mtDNA levels and hatching rate in spoon null mutants. In larp-10A, loss of phosphorylation by Pink1; when associated with A-66; A-107; A-182; A-186; A-828; A-1119 and 1510-A-A-1512.
Partially rescues mtDNA levels and hatching rate in spoon null mutants; when associated with A-107. In larp-10A, loss of phosphorylation by Pink1; when associated with A-107; A-182; A-186; 219-A-A-221; A-828; A-1119 and 1510-A-A-1512.
Partially rescues mtDNA levels and hatching rate in spoon null mutants; when associated with A-182. In larp-10A, loss of phosphorylation by Pink1; when associated with A-66; A-107; A-182; 219-A-A-221; A-828; A-1119 and 1510-A-A-1512.
Partially rescues mtDNA levels and hatching rate in spoon null mutants; when associated with A-186. In larp-10A, loss of phosphorylation by Pink1; when associated with A-66; A-107; A-186; 219-A-A-221; A-828; A-1119 and 1510-A-A-1512.
Partially rescues mtDNA levels and hatching rate in spoon null mutants; when associated with A-66. In larp-10A, loss of phosphorylation by Pink1; when associated with A-66; A-182; A-186; 219-A-A-221; A-828; A-1119 and 1510-A-A-1512.
Partially rescues nascent protein synthesis and PolG1 expression in mitochondria containing deleterious mutations. Partially rescues mtDNA levels and hatching rate in spoon null mutants. In larp-10A, loss of phosphorylation by Pink1; when associated with A-66; A-107; A-182; A-186; 219-A-A-221; A-828 and 1510-A-A-1512.
Phosphomimetic mutant, partially rescues mtDNA levels and hatching rate in spoon null mutants.
Phosphomimetic mutant, partially rescues mtDNA levels and hatching rate in spoon null mutants; when associated with D-107.
Phosphomimetic mutant, partially rescues mtDNA levels and hatching rate in spoon null mutants; when associated with D-182.
Phosphomimetic mutant, partially rescues mtDNA levels and hatching rate in spoon null mutants; when associated with D-186.
Phosphomimetic mutant, partially rescues mtDNA levels and hatching rate in spoon null mutants; when associated with D-66.
Phosphomimetic mutant, severe reduction in ability to rescue mtDNA levels and hatching rate in spoon null mutants.
DNA polymerase epsilon catalytic subunit 1
Nudix hydrolase domain-containing protein
CCR4-NOT transcription complex subunit 1
CCR4-NOT transcription complex subunit 1 CAF1-binding
CCR4-NOT transcription complex subunit 1 HEAT repeat
CCR4-NOT transcription complex subunit 1 TTP binding
CCR4-Not complex component Not1 C-terminal
Probable mitochondrial import inner membrane translocase subunit Tim17 1
Ribosomal L1 domain-containing protein CG13096
Vacuolar protein sorting-associated protein 72 homolog
Serine/threonine-protein phosphatase 2B catalytic subunit 1
6-phosphogluconate dehydrogenase C-terminal
6-phosphogluconate dehydrogenase, decarboxylating
Mediator of RNA polymerase II transcription subunit 25
In AR66; slower channel activation and reduction of peak current.
Voltage-dependent calcium channel alpha-1 subunit IQ
Voltage-dependent calcium channel type D subunit alpha-1
Pre-mRNA-splicing regulator female-lethal(2)D
Rab3 GTPase-activating protein catalytic subunit
Serine/threonine-protein phosphatase PP-Y
Uncharacterized zinc finger protein CG12744
Inhibits interaction with loco. Does not inhibit apical cell membrane localization in neuroblasts.
Transcription initiation factor TFIID subunit 10
THUMP domain-containing protein 1 homolog
Tyrosine-protein phosphatase non-receptor type 61F
No effect on RNA-binding; when associated with D-658; I-724 and R-665.
No effect on RNA-binding; when associated with D-658; I-724 and R-749.
No effect on RNA-binding; when associated with D-658; R-665 and R-749.
No effect on RNA-binding; when associated with L-632.
No effect on RNA-binding; when associated with L-634.
No effect on RNA-binding; when associated with R-665; I-724 and R-749.
Reduced RNA-binding. Complete loss; when associated with A-606.
Reduced RNA-binding. Complete loss; when associated with R-609.
Vacuolar protein 14 C-terminal Fig4-binding
Guanylate kinase-associated protein mars
CCR4-Not complex component Not N-terminal
Low molecular weight phosphotyrosine protein phosphatase 2
DNA-directed RNA polymerase II subunit RPB11
Eukaryotic translation initiation factor 3 subunit F-2
Putative ATP-dependent RNA helicase BoYb
Transmembrane protein 70 homolog, mitochondrial
In a15, loss of female-specific DSX splicing and male fertility.
In a36; loss of female-specific DSX splicing. Loss of male fertility.
In d1; greatly reduced female-specific DSX splicing. Retains male fertility.
In d2; greatly reduced female-specific DSX splicing.
In d3; greatly reduced female-specific DSX splicing. Retains male fertility.
In d4; loss of female-specific DSX splicing. Greatly reduced male fertility.
In d5; loss of female-specific DSX splicing. Loss of male fertility.
In pm1; loss of female-specific DSX splicing. Loss of male fertility.
In pm2; no female-specific DSX splicing. Some low male fertility.
In pm3; greatly reduced female-specific DSX splicing. Retains male fertility and temperature-sensitive phenotype.
In pm4; loss of female-specific DSX splicing. Retains male fertility and temperature-sensitive phenotype.
In ts1; little female-specific DSX splicing. Loss of male fertility and temperature-sensitive phenotype.
In ts2; temperature-sensitive phenotype.
Tetratricopeptide repeat protein 19 homolog, mitochondrial
Severely diminishes UTP inhibition of CPSase; in Su(b).
Reduced female fertility caused by perturbed oogenesis which includes chorion defects and general ovariole disintegration due to apoptosis.
Abolishes binding to Diap2 but has no effect on Drice processing or activity.
No effect on binding to Diap2 but may affect stability of complex formed with Diap2.
In strain: Canton-S, G02, G130 and G140.
Decreased transposon silencing but no effect on nuclear localization or interaction with piwi.
Thioredoxin reductase-like selenoprotein T homolog CG3887
Putative fatty acyl-CoA reductase CG8303
Tumor necrosis factor receptor superfamily member wengen
cGMP-specific 3',5'-cyclic phosphodiesterase
Constitutively active kinase; reduces microtubule sliding to similar levels of wild-type (in vitro).
Loss of catalytic activity; increases microtubule sliding (in vitro).
Serine/threonine-protein kinase tricornered
Trafficking protein particle complex subunit 10
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with 958-A-A-959; 969-A-A-970; A-1002; A-1019; 1031-A-A-1032; A-1035; A-1043; 1047-A-A-1048; A-1067; A-1071; A-1075; A-1093; A-1102 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; 969-A-A-970; A-1002; 1031-A-A-1032; A-1035; A-1043; 1047-A-A-1048; A-1067; A-1071; A-1075; A-1093; A-1102 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; 969-A-A-970; A-1002; A-1019; 1031-A-A-1032; A-1035; 1047-A-A-1048; A-1067; A-1071; A-1075; A-1093; A-1102 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; 969-A-A-970; A-1002; A-1019; 1031-A-A-1032; A-1035; A-1043; 1047-A-A-1048; A-1067; A-1071; A-1075; A-1093 and A-1102.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; 969-A-A-970; A-1002; A-1019; 1031-A-A-1032; A-1035; A-1043; 1047-A-A-1048; A-1067; A-1071; A-1075; A-1093 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; 969-A-A-970; A-1002; A-1019; 1031-A-A-1032; A-1035; A-1043; 1047-A-A-1048; A-1067; A-1071; A-1075; A-1102 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; 969-A-A-970; A-1002; A-1019; 1031-A-A-1032; A-1035; A-1043; 1047-A-A-1048; A-1067; A-1071; A-1093; A-1102 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; 969-A-A-970; A-1002; A-1019; 1031-A-A-1032; A-1035; A-1043; 1047-A-A-1048; A-1067; A-1075; A-1093; A-1102 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; 969-A-A-970; A-1002; A-1019; 1031-A-A-1032; A-1035; A-1043; 1047-A-A-1048; A-1071; A-1075; A-1093; A-1102 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; 969-A-A-970; A-1002; A-1019; 1031-A-A-1032; A-1035; A-1043; A-1067; A-1071; A-1075; A-1093; A-1102 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; 969-A-A-970; A-1002; A-1019; 1031-A-A-1032; A-1043; 1047-A-A-1048; A-1067; A-1071; A-1075; A-1093; A-1102 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; 969-A-A-970; A-1002; A-1019; A-1035; A-1043; 1047-A-A-1048; A-1067; A-1071; A-1075; A-1093; A-1102 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; 969-A-A-970; A-1019; 1031-A-A-1032; A-1035; A-1043; 1047-A-A-1048; A-1067; A-1071; A-1075; A-1093; A-1102 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 958-A-A-959; A-1002; A-1019; 1031-A-A-1032; A-1035; A-1043; 1047-A-A-1048; A-1067; A-1071; A-1075; A-1093; A-1102 and A-1140.
Probable loss of Cdk1-mediated regulation leads to lack of dissociation from chromatin and block of replication resulting in anaphase chromosome bridging during mid-blastula transition in embryos; in the eye imaginal disk, results in complete lethality with pupae developing into headless nearly adult flies; when associated with A-946; 969-A-A-970; A-1002; A-1019; 1031-A-A-1032; A-1035; A-1043; 1047-A-A-1048; A-1067; A-1071; A-1075; A-1093; A-1102 and A-1140.
Significant loss of DNA underreplication in larval salivary glands; when associated with 1076-A-A-1077.
Significant loss of DNA underreplication in larval salivary glands; when associated with 1101-A--A-1103.
Translation machinery-associated protein 7 homolog
Loss of InsP6 phosphatase activity. Fails to rescue the filopodia formation phenotype of null mutants.
Accelerates formation and decay of the FAD radical.
Slows down the decay of the FAD radical.
DNA repair protein complementing XP-A cells homolog
Staphylococcal nuclease domain-containing protein 1
Required for binding to Nup93-1 and anchoring to the nuclear pore complex
In strain: MEL11, MEL12, ZBMEL82, ZBMEL131, ZBMEL186, ZBMEL191 and ZBMEL229.
Transmembrane emp24 domain-containing protein bai
Cytochrome c oxidase subunit 5A, mitochondrial
Inactive selenide, water dikinase-like protein
ATP synthase membrane subunit K, mitochondrial
In 6; normal eye color. Eyes are brown due to a reduction in red pigment production in a w/white co2 mutant background.
In T50; normal eye color. Eyes are brown due to a reduction in red pigment production in a w/white co2 mutant background.
Regulator of nonsense transcripts 1 homolog
In D-mib4; induces defects in Notch signaling.
Cytoplasmic phosphatidylinositol transfer protein 1
Conserved oligomeric Golgi complex subunit 7
Dual specificity tyrosine-phosphorylation-regulated kinase 2
In strain: Berkeley, k1, k2, k3, k5, k8, k9 and k11.
In strain: Berkeley, k1, k2, k3, k5, k8, k9, k11, pe1, pe4, pe45, pe5, wi4, wi7, wi10, wi13, wi18 and wi19.
In strain: Berkeley, k1, k8, Oregon-R, pe7 and pe10.
In strain: Berkeley, k3, k8, k9, wi10 and wi19.
CTD nuclear envelope phosphatase 1 homolog
Loss of phosphoribosylglycinamide formyltransferase enzymatic activity.
Trifunctional purine biosynthetic protein adenosine-3
Sodium/potassium/calcium exchanger Nckx30C
Phosphatidylinositol-binding clathrin assembly protein LAP
ATP synthase-coupling factor 6, mitochondrial
Transport and Golgi organization protein 2
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
Gamma-tubulin complex component 2 homolog
In vir1ts; transforms XX animals into intersexes at 29 degrees Celsius.
In vir2f; XX-specific lethal, interferes with sex determination and dosage compensation.
Probable E3 ubiquitin-protein ligase HERC2
Tetratricopeptide repeat protein 30 homolog
U3 small nucleolar RNA-associated protein 18 homolog
MYND-type zinc finger-containing chromatin reader Zmynd8
Necessary for interaction with His3.3A and His3.3B
In isoform 2, isoform 3, isoform 5 and isoform 6.
In isoform 2, isoform 3, isoform 5, isoform 6 and isoform 7.
Putative odorant receptor 69a, isoform A
Putative odorant receptor 69a, isoform B
Disruption of dimer formation and reduced solubility.
Disruption of tetramer formation but not of dimer formation.
Abolishes interaction with Edc3; when associated with A-281; A-284 and A-288.
Abolishes interaction with Edc3; when associated with A-281; A-284 and A-292.
Abolishes interaction with Edc3; when associated with A-281; A-288 and A-292.
Abolishes interaction with Edc3; when associated with A-284; A-288 and A-292.
In CL-AA; reduced interaction with Gyf and Patr-1 but has no effect on interaction with 4E-T; when associated with A-285.
In CL-AA; reduced interaction with Gyf and Patr-1 but has no effect on interaction with 4E-T; when associated with A-289.
In LK-AA; reduced interaction with Gyf, Patr-1 and 4E-T; when associated with A-310.
In LK-AA; reduced interaction with Gyf, Patr-1 and 4E-T; when associated with A-314.
Important for inositol polyphosphate binding
Important for promoting lysosomal/autophagosomal degradation of PXo bodies following inorganic phosphate (Pi) starvation
Not affected by phosphonoformic acid (PFA).
V-type proton ATPase catalytic subunit A isoform 2
In allele ssm; maternal effect embryonic lethal mutation which impairs maternal histone deposition in the male pronucleus.
Polypeptide N-acetylgalactosaminyltransferase 2
Replication protein A 70 kDa DNA-binding subunit
General transcription factor IIF subunit 2
Signal recognition particle subunit SRP68
26S proteasome non-ATPase regulatory subunit 7
In strain: OK17, OK94, Z42, Z55, Z64 and Z74.
In strain: MEL01, MEL02, MEL12, MEL13, MEL14, MEL15, MEL16, MEL17, MEL18, MEL19, MEL20, ZBMEL84, ZBMEL95, ZBMEL131, ZBMEL157, ZBMEL191, ZBMEL377 and ZBMEL398.
In strain: MEL11, ZBMEL145, ZBMEL131, ZBMEL229 and ZBMEL384.
In strain: MB01a, MB13a, MB15b and MB46b.
In strain: MB34a, MB36a, MB45b, MB46b, MB47a and MB58b.
In strain: Berkeley, JP-1, JP-5, JP-15, JP-35, JP-55, JP-65, JP-84, KN-12, KN-22 and KN-27.
In strain: JP-75, KN-7, KN-15, KN-17, KN-21 and KN-23.
DRY motif; important for ligand-induced conformation changes
NPxxY motif; important for ligand-induced conformation changes and signaling
Decreased function in sphingolipid catabolic process.
Loss of function in sphingolipid catabolic process.
No effect on function in sphingolipid catabolic process.
Zinc finger FYVE domain-containing protein 26 homolog
DDB1- and CUL4-associated factor 15 WD40 repeat-containing
Dimethyladenosine transferase 1, mitochondrial
Abolishes mono-ADP-ribosylation and Sec body formation.
Protein mono-ADP-ribosyltransferase Parp16
Eukaryotic translation initiation factor 3 subunit B
Causes inverted left-right asymmetry of the midgut and hindgut in embryos and adults. Flies are viable and fertile, but display mildly reduced hatching rate and reduced life span.
Loss of function in specification of gut left-right asymmetry.
Loss of function in specification of gut left-right asymmetry; when associated with A-106 and A-156.
Loss of function in specification of gut left-right asymmetry; when associated with A-106 and A-382.
Loss of function in specification of gut left-right asymmetry; when associated with A-155 and A-382.
Loss of the ability to promote the normal dextral looping of the spermiduct.
Retinoblastoma-binding protein 5 homolog
Serine/threonine-protein phosphatase 4 regulatory subunit 3
Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central
Does not affect catalysis, inhibitor binding or protein folding; when associated with A-136.
Does not affect catalysis, inhibitor binding or protein folding; when associated with A-158.
In allele MtnA-3 and strain: AF6, Highgrove, Indiana, LA20, Taiwan, ZH18, ZH21, ZH27, ZS11, ZS30 and ZS56.
Sulfatase N-terminal domain-containing protein
Set1/Ash2 histone methyltransferase complex subunit ASH2
Guanine nucleotide-binding protein-like 3 homolog
Zinc finger SWIM domain-containing protein 8 homolog
Serine/threonine-protein kinase minibrain
Mannose-P-dolichol utilization defect 1 protein homolog
Partial loss of transport activity and increased sensitivity to blocking by the magnesium ion.
Mediator of RNA polymerase II transcription subunit 26
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Protein phosphatase 1 regulatory subunit 21 N-terminal
Abolishes iron binding and endocytosis by epithelial cells; does not rescue Nrx-IV/Nrx mislocalization and tube overelongation in trachea of knockout embryos; when associated with 798-A--L-819 del.
Loss of cell membrane localization. Rescues Nrx-IV/Nrx mislocalization and tube overelongation in trachea of knockout embryos. Reduces iron binding; rescues Nrx-IV/Nrx mislocalization and tube overelongation in trachea of knockout embryos; when associated with F-231. Abolishes iron binding and endocytosis by epithelial cells; does not rescue Nrx-IV/Nrx mislocalization and tube overelongation in trachea of knockout embryos; when associated with F-533.
Reduces iron binding; rescues Nrx-IV/Nrx mislocalization and tube overelongation in trachea of knockout embryos; when associated with 798-A--L-819 del.
Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
In allele sub-1794; elevated levels of X chromosome non-disjunction.
In allele sub-Dub; meiotic non-disjunction in males and females.
In botv510; induces defects in wing patterning due to impaired movement of morphogens.
In botv514; induces defects in wing patterning due to impaired movement of morphogens.
In botv8; induces defects in wing patterning due to impaired movement of morphogens.
Abolishes binding to Z600; when associated with A-235 and A-239.
Abolishes binding to Z600; when associated with A-235 and A-242.
Abolishes binding to Z600; when associated with A-239 and A-242.
Cation channel complex component UNC80 N-terminal
In swi-t467; lethal during puparium formation.
DNA-directed RNA polymerase III subunit RPC2
Eukaryotic translation initiation factor 2 subunit 2
Essential for nuclear membrane localization
Essential for nuclear membrane localization and germline stem cell maintenance
Phosphomimetic mutant which displays a decrease in the number of mitotic cells.
Prevents phosphorylation and displays an increase in the number of mitotic cells.
Required for binding to Med and germline stem cell maintenance
Probable G-protein coupled receptor Mth-like 4
Small conductance calcium-activated potassium channel protein
Transcription initiation factor TFIID subunit 2
Mannose-1-phosphate guanyltransferase beta
Impairs autoinhibition; when associated with A-377 and A-378. Loss of activity and impaired autoinhibition; when associated with A-377; A-378 and S-304.
Impairs autoinhibition; when associated with A-377 and A-450. Loss of activity and impaired autoinhibition; when associated with A-377; A-450 and S-304.
Impairs autoinhibition; when associated with A-378 and A-450. Loss of activity and impaired autoinhibition; when associated with A-378; A-450 and S-304.
In ari-1a; Loss of catalytic activity. Late pupal lethal and adult escapers have a reduced lifespan and thinner bristles. Nuclei in larval muscles (myonuclei) are displaced from the cell membrane, exhibit clustering and morphological defects, likely due to the mislocalization of the LINC complex. Reduced degradation of the LINC complex member koi.
In ari-1b; Loss of catalytic activity. Late pupal lethal and adult escapers have a reduced lifespan and thinner bristles. Nuclei in larval muscles (myonuclei) are displaced from the cell membrane, exhibit clustering and morphological defects, likely due to the mislocalization of the LINC complex; when associated with E-187.
In ari-1b; Loss of catalytic activity. Late pupal lethal and adult escapers have a reduced lifespan and thinner bristles. Nuclei in larval muscles (myonuclei) are displaced from the cell membrane, exhibit clustering and morphological defects, likely due to the mislocalization of the LINC complex; when associated with P-332.
In ari-1d; late pupal lethal and adult escapers have a reduced lifespan and thinner bristles. Nuclei in larval muscles (myonuclei) are displaced from the cell membrane, exhibit clustering and morphological defects.
In ari1-2; lethal phenotype and loss of interaction with Ubc10.
In ari1-3; lethal phenotype and no loss of interaction with Ubc10.
Loss of catalytic activity and impaired autoinhibition; when associated with A-377; A-378 and A-450.
Glycine cleavage system H protein, mitochondrial
U3 small nucleolar RNA-associated protein 20 C-terminal
U3 small nucleolar RNA-associated protein 20 N-terminal
Abolishes binding to H3K9me3 peptide, reduces nuclear foci association in nurse cells, cannot inhibit transposon hyperexpression and is unable to rescue sterility phenotype of knockout mutants.
Disrupts dimerization, reduces nuclear foci association in nurse cells, cannot inhibit transposon hyperexpression and is unable to rescue sterility phenotype of knockout mutants; when associated with A-34.
Disrupts dimerization, reduces nuclear foci association in nurse cells, cannot inhibit transposon hyperexpression and is unable to rescue sterility phenotype of knockout mutants; when associated with A-76.
Disrupts interaction with del/deadlock and nuclear foci accumulation, cannot inhibit transposon hyperexpression and is unable to rescue sterility phenotype of knockout mutants. Reduced protein stability.
Required for interaction with del/deadlock
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial
Dorsal-ventral patterning protein tolloid
Oxygen-dependent coproporphyrinogen-III oxidase
In strain: Canton-S, SENGWA2, SENGWA22, SENGWA29, SENGWA32 and SENGWA51.
In strain: SENGWA2, SENGWA22, SENGWA29, SENGWA30, SENGWA32, SENGWA37, SENGWA51, WSII16, WSII19 and WSII49.
In strain: SENGWA2, SENGWA22, SENGWA29, SENGWA32, SENGWA37, SENGWA51, WSII19 and WSII49.
In strain: SENGWA2, SENGWA29, SENGWA32, SENGWA51, WSII19 and WSII49.
In strain: SENGWA22, SENGWA29, SENGWA37 and SENGWA51.
In strain: SENGWA22, SENGWA30 and WSII16.
In strain: SENGWA29, SENGWA30, SENGWA37 and SENGWA51.
Probable Golgi SNAP receptor complex member 2
Abolishes phosphorylation by TORC1 signaling. Results in loss of nucleolar localization.
Reduces expression levels; does not affect phosphorylation.
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Serine/threonine-protein phosphatase alpha-3 isoform
Abrogates microtubule severing and ATPase activity.
Abrogates microtubule severing and ATPase activity. Induces accumulation of hyperstable microtubules at the neuromuscular junction presynpatic terminal and reduces synaptic area. Reduces adult lifespan and impairs climbing activity.
Abrogates microtubule severing and impairs ATPase activity.
Abrogates microtubule severing and strongly impairs ATPase activity.
Impairs interaction with microtubules and promotes hexamerization.
Impairs microtubule severing and ATPase activity.
Required for interaction with microtubules
Required for localization to punctate cytoplasmic foci
Strongly impairs microtubule severing and ATPase activity but does not affect interaction with microtubules; when associated with A-469 and A-473.
Strongly impairs microtubule severing and ATPase activity but does not affect interaction with microtubules; when associated with A-469 and A-474.
Strongly impairs microtubule severing and ATPase activity but does not affect interaction with microtubules; when associated with A-473 and A-474.
Strongly impairs microtubule severing and ATPase activity.
Strongly impairs microtubule severing and weakly impairs ATPase activity.
Strongly impairs microtubule severing and weakly impairs ATPase activity; when associated with A-465 and A-471.
Strongly impairs microtubule severing and weakly impairs ATPase activity; when associated with A-465 and A-472.
Strongly impairs microtubule severing and weakly impairs ATPase activity; when associated with A-471 and A-472.
Sufficient for interaction with microtubules and microtubule severing
Weakly impairs microtubule severing and ATPase activity.
Weakly impairs microtubule severing and strongly impairs ATPase activity.
Conserved oligomeric Golgi complex subunit 5
Neural/ectodermal development factor IMP-L2
Nuclear speckle splicing regulatory protein 1 N-terminal
Putative ATP-dependent RNA helicase SoYb
No change in baseline secretion but eliminates increased secretion normally caused by coexpression with Hip14 and reduces intracellular levels of Sog.
No effect on secretion when coexpressed with Hip14.
Eukaryotic translation initiation factor 3 subunit K
Exocyst complex subunit Exo70 C-terminal
Transcription initiation factor TFIID subunit 9
Causes accumulation exclusively in the cytoplasm.
Eukaryotic translation initiation factor eIF1
Ribosome biogenesis protein WDR12 homolog
Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66
Probable G-protein coupled receptor Mth-like 2
Ankyrin repeat and LEM domain-containing protein 2 homolog
Pupal lethality at temperatures above 22 degrees Celsius. Larvae initially have normal brain sizes, but later in the third larval stage, the brain is smaller than in wild-type counterparts.
Serine/threonine-protein kinase Genghis Khan
Small ribosomal subunit protein uS17 N-terminal
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1
Fails to inhibit growth. Loss of localization to apical membranes. Not necessary to modify src-induced overgrowth.
Fails to rescue the loss of terminal arborization in mechanosensory neurons in null flies.
Heme-copper oxidase subunit III family profile
Abolishes interaction with lack; when associated with A-453.
Abolishes interaction with lack; when associated with A-455.
Transcription initiation factor IIA subunit 2
Abolishes cardiolipin hydrolase activity.
In strain: =MEL01, MEL02, MEL11, MEL12, MEL14, MEL15, MEL16, MEL17, MEL18, MEL19, MEL20, ZBMEL82, ZBMEL95, ZBMEL131, ZBMEL145, ZBMEL157, ZBMEL186, ZBMEL191, ZBMEL229, ZBMEL377, ZBMEL384 and ZBMEL398.
In strain: MEL20, ZBMEL131, ZBMEL186, ZBMEL384 and ZBMEL398.
In strain: ZBMEL191, ZBMEL229, ZBMEL377 and ZBMEL384.
In zuc(RS49); produce some eggs with a more normal eggshell phenotype in addition to the ventralized eggs compared to null mutants.
In zuc(SG63); produce some eggs with a more normal eggshell phenotype in addition to the ventralized eggs compared to null mutants.
Biogenesis of lysosome-related organelles complex 1 subunit 6
Putative polypeptide N-acetylgalactosaminyltransferase 10
Biogenesis of lysosome-related organelles complex 1 subunit 5
Abolishes interaction with Nedd4 and reduces ubiquitination.
In mcd5; induces loss of microchaetae sensory precursors.
In su42c; deltex-like mutation that induces outstreched wings and variability-fused ocelli.
Processed neurogenic locus Notch protein
Eukaryotic translation initiation factor 3 subunit G-2
PTB domain-containing adapter protein ced-6
Eukaryotic translation initiation factor 3 subunit M
Glycoside hydrolase family 31 N-terminal
Transcription factor TFIIIC triple barrel
Glyceraldehyde-3-phosphate dehydrogenase 2
Mediator of RNA polymerase II transcription subunit 24
Cleavage stimulation factor subunit 1 dimerisation
Alpha/beta-tubulin-N-acetyltransferase 9
In AAA; overexpression results in a weak thorax cleft.
In AcDel; overexpression results in a weak thorax cleft. Microtubule polymerization activity is slightly reduced.
Peroxisome membrane anchor protein Pex14p N-terminal
Mediator of RNA polymerase II transcription subunit 29
Rab3 GTPase-activating protein non-catalytic subunit
For hydroxyacyl-coenzyme A dehydrogenase activity
Important for hydroxyacyl-coenzyme A dehydrogenase activity
Important for long-chain enoyl-CoA hydratase activity
Decreased interaction with F-BAR domain. No effect on interaction with Dap160.
Abolishes RNA-binding; when associated with 236-A--A-240.
Abolishes RNA-binding; when associated with A-210.
RNA-binding unit probably involved in Piwi-dependent recruitment and single-stranded RNA-PPNP complex formation
Reduces binding to Panx, increases cytoplasmic localization and increases transposon expression after loss of gene.
Retains localization to the nucleus and interaction with Panx but reduces interaction with Nxt1. Increases transposon expression after loss of gene.
Retains localization to the nucleus and interaction with Panx. Increases transposon expression after loss of gene.
Retains localization to the nucleus and interaction with Panx. Reduces transposon expression after loss of gene.
CBY1-interacting BAR domain-containing protein homolog
In allele K1214; eggs exhibit thin shell and flimsy dorsal appendages.
Ribosomal RNA-processing protein 7 C-terminal
Putative protein kinase C delta type homolog
Resistance to inhibitors of cholinesterase protein 3 N-terminal
Increases apoptosis in the eye imaginal disk thereby leading to a rough eye phenotype.
Dehydrogenase/reductase SDR family protein 7-like
In chinmo-M33; mushroom body neuroblast clones contain increased numbers of late-born alpha/beta type neurons and fewer early-born gamma type neurons.
Transmembrane protein 11 homolog, mitochondrial
Probable U3 small nucleolar RNA-associated protein 11
In strain: Usa7, Z36, Z50, Zim7, Zim10, Zim13, Zim15, Zim16, Zim18, Zim39 Zim41 and Zim42.
ATP synthase subunit gamma, mitochondrial
Abolishes glycosyltransferase activity. Not able to rescue lethality caused by SF32 mutation.
Polypeptide N-acetylgalactosaminyltransferase 35A
Ribosome maturation protein SDO1/SBDS C-terminal
Ribosome maturation protein SDO1/SBDS N-terminal
Ribosome maturation protein SDO1/SBDS central
Harmonin-binding protein USHBP1 PDZ-binding
Peroxidase-like; mediates peroxidase activity
In strain: DI7, Draveil, KY024, KY038, Loua, Monty5 and ZW141.
In strain: DI7, Draveil, KY024, KY038, Loua, Monty5, Tahiti and ZW141.
12 X 26 AA approximate tandem repeats, Glu, Met-rich
Defective chorion protein, FC106 isoform
Defective chorion protein, FC125 isoform
Defective chorion protein, FC177 isoform