Polynucleotide kinase-phosphatase C-terminal
Polynucleotide kinase-phosphatase ligase
Aconitase A/isopropylmalate dehydratase small subunit swivel
N6 adenine-specific DNA methyltransferase N-terminal
Gamma-glutamylcyclotransferase AIG2-like
Resolvase/invertase-type recombinase catalytic
Ribose-phosphate pyrophosphokinase N-terminal
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Lipocalin-like domain-containing protein
DNA replication/recombination mediator RecO N-terminal
Sodium/calcium exchanger membrane region
Major facilitator superfamily (MFS) profile
Tryptophan synthase beta chain-like PALP
Dinitrogenase iron-molybdenum cofactor biosynthesis
Glycogen debranching enzyme bacterial and archaeal type N-terminal
Prepilin type IV endopeptidase peptidase
ABC-type uncharacterised transport system
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Polysaccharide biosynthesis protein C-terminal
Could be important to modulate the pK values of the two catalytic cysteine residues
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Plays an important role in discriminating NADH against NADPH
Large ribosomal subunit protein bL9 C-terminal
Polymerase/histidinol phosphatase N-terminal
Transposon Tn7 transposition protein TnsD C-terminal
Meso-diaminopimelate D-dehydrogenase C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Transposase IS116/IS110/IS902 C-terminal
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Glycosyltransferase subfamily 4-like N-terminal
Plays an important role in substrate specificity
Translation elongation factor EFTs/EF1B dimerisation
Small ribosomal subunit protein uS4 N-terminal
S-adenosylmethionine-dependent methyltransferase
Sporulation transcription regulator WhiA N-terminal
Glutathionylspermidine synthase pre-ATP-grasp-like
CobB/CobQ-like glutamine amidotransferase
Flagellar Assembly Protein A N-terminal region
Thiamine pyrophosphate enzyme TPP-binding
Schiff-base intermediate with substrate; via pyruvic acid
Aminoacyl-transfer RNA synthetases class-II family profile
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
Cation-transporting P-type ATPase N-terminal
Helix-hairpin-helix DNA-binding motif class 1
RNA polymerase sigma factor 70 region 4 type 2
Alpha-D-phosphohexomutase alpha/beta/alpha
Solute-binding protein family 3/N-terminal
Protein O-mannosyl-transferase C-terminal four TM
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Sugar fermentation stimulation protein C-terminal
Thiamin pyrophosphokinase thiamin-binding
ATP-dependent DNA helicase RecG C-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Flagellar hook-length control protein-like C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
Flagellar motor switch protein FliN-like C-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Septum formation inhibitor MinC C-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Release factor glutamine methyltransferase N-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Type I restriction modification DNA specificity
Phosphoadenosine phosphosulphate reductase
Thymidylate synthase/dCMP hydroxymethylase
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Type III secretion system flagellar brake protein YcgR PilZN
Schiff-base intermediate with D-ribose 5-phosphate
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding
ATPsynthase alpha/beta subunit N-terminal extension
Transcription elongation factor GreA/GreB C-terminal
Cell envelope-related transcriptional attenuator
Bacterial type II secretion system protein E
Membrane fusion protein biotin-lipoyl like
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Putative regulatory protein FmdB Zinc ribbon
Glycerophosphoryl diester phosphodiesterase membrane
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
DNA-directed DNA polymerase family A palm
NADH:ubiquinone oxidoreductase-like 20kDa subunit
Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT C-terminal
Pyridoxamine 5'-phosphate oxidase putative
Bacterial bifunctional deaminase-reductase C-terminal
Important for beta-aspartyl-AMP intermediate formation
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Positions MEP for the nucleophilic attack
Glycosyltransferase family 28 N-terminal
Carbamoyl-phosphate synthase small subunit N-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
NIF system FeS cluster assembly NifU N-terminal
Reversibly protonated during proton transport
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Glucosamine/galactosamine-6-phosphate isomerase
Transcription factor NikR nickel binding C-terminal
RDXXRA motif of the pArg binding pocket involved in allosteric regulation
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Alanyl-transfer RNA synthetases family profile
RND efflux pump membrane fusion protein barrel-sandwich
Thiamine pyrophosphate enzyme N-terminal TPP-binding
O-(3'-phospho-DNA)-tyrosine intermediate
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
6-hydroxymethylpterin diphosphokinase MptE-like
Diacylglycerol glucosyltransferase N-terminal
Glycosyl transferase family 28 C-terminal
Sporulation stage II protein D amidase enhancer LytB N-terminal
Type III restriction enzyme C-terminal endonuclease
Large ribosomal subunit protein uL2 C-terminal
Proton acceptor; for glutaminase activity
Type II restriction enzyme and methyltransferase RM.Eco57I-like
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
RNA 2-O ribose methyltransferase substrate binding
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Tryptophan RNA-binding attenuator protein
Aspartate/homoserine dehydrogenase NAD-binding
DNA mismatch repair proteins mutS family
Transcription elongation factor GreA/GreB N-terminal
Pyruvate/ketoisovalerate oxidoreductase catalytic
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Dipicolinate synthase subunit A N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Nitrite/Sulfite reductase ferredoxin-like
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Nucleophile; cysteine thiosulfonate intermediate
Non-canonical purine NTP phosphatase/PRRC1
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Proton acceptor; for processing activity
S-adenosylmethionine decarboxylase alpha chain
S-adenosylmethionine decarboxylase beta chain
RNA binding; important for wobble base 34 recognition
Polysaccharide biosynthesis protein CapD-like
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Anthranilate synthase component I N-terminal
Large ribosomal subunit protein uL15/eL18
Important for interaction with partner proteins
NADH:flavin oxidoreductase/NADH oxidase N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
S-adenosyl-L-homocysteine hydrolase NAD binding
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Phosphomannose isomerase type I catalytic
Prokaryotic-type class I peptide chain release factors
Penicillin-binding protein transpeptidase
Glycosyl hydrolase family 98 putative carbohydrate-binding module
Pseudouridine synthase I TruA alpha/beta
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Pyruvate phosphate dikinase AMP/ATP-binding
Terminase large subunit-like endonuclease
BREX system Lon protease-like BrxL N-terminal
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Phosphoribosylformylglycinamidine synthase linker
Lysidine-tRNA(Ile) synthetase C-terminal
Large ribosomal subunit protein uL6 alpha-beta
Translation elongation factor P/YeiP central
Important for substrate specificity; cannot use PPi as phosphoryl donor
O-(5'-phospho-DNA)-tyrosine intermediate
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
UDP-glucose/GDP-mannose dehydrogenase C-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Aromatic amino acid beta-eliminating lyase/threonine aldolase
Increases nucleophilicity of active site Cys
Ribonucleotide reductase large subunit C-terminal
Ribonucleotide reductase large subunit N-terminal
Shikimate dehydrogenase substrate binding N-terminal
ABC transporter substrate-binding protein PnrA-like
Putative Flp pilus-assembly TadG-like N-terminal
Chromosomal replication initiator DnaA C-terminal
Polysaccharide chain length determinant N-terminal
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Membrane insertase YidC/Oxa/ALB C-terminal
Gly-cisPro motif, important for rejection of L-amino acids
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Flagellar hook-associated protein 2 C-terminal
Flagellar hook-associated protein 2 N-terminal
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Ribulose bisphosphate carboxylase large subunit C-terminal
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Could play a key role in the communication between the regulatory and the substrate sites
Schiff-base intermediate with acetaldehyde
Phosphatidylglycerol lysyltransferase C-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Dolichyl-phosphate-mannose--protein mannosyltransferase
Cysteine sulfenic acid (-SOH) intermediate
Interchain (with Cys-214); in linked form
Interchain (with Cys-53); in linked form
Carboxypeptidase regulatory-like domain-containing protein
Pyrimidine nucleoside phosphorylase C-terminal
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Orn/Lys/Arg decarboxylases family 1 pyridoxal-P attachment site
Ribosomal RNA adenine methylase transferase N-terminal
Interaction with polymerase core subunit RpoC
Glycosyl transferase family 3 N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
ATP synthase F1 complex delta/epsilon subunit N-terminal
Membrane iron-sulfur containing protein FtrD-like