ABC-type glycine betaine transport system substrate-binding
Penicillin-binding protein transpeptidase
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Ribulose bisphosphate carboxylase small subunit
Peptide methionine sulfoxide reductase MsrA
Peptide methionine sulphoxide reductase MsrA
Organic solvent tolerance-like N-terminal
Activator of Hsp90 ATPase homologue 1-like C-terminal
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
O-(5'-phospho-DNA)-tyrosine intermediate
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Large ribosomal subunit protein uL2 C-terminal
Four-carbon acid sugar kinase N-terminal
Four-carbon acid sugar kinase nucleotide binding
Glucose-methanol-choline oxidoreductase N-terminal
Thymidylate synthase/dCMP hydroxymethylase
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Major facilitator superfamily (MFS) profile
Heme-copper oxidase subunit III family profile
Solute-binding protein family 3/N-terminal
Saccharopine dehydrogenase-like C-terminal
Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich
Glycosyl hydrolases family 2 sugar binding
Inosine/uridine-preferring nucleoside hydrolase
Flagellar assembly protein FliH/Type III secretion system HrpE
NADH:ubiquinone oxidoreductase-like 20kDa subunit
PhoD-like phosphatase metallophosphatase
Putative exodeoxyribonuclease 8 PDDEXK-like
Nitrile hydratase alpha /Thiocyanate hydrolase gamma
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Exonuclease VII large subunit C-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
Resolvase/invertase-type recombinase catalytic
Tryptophan synthase beta chain-like PALP
RNA 2-O ribose methyltransferase substrate binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Aconitase A/isopropylmalate dehydratase small subunit swivel
TRAP C4-dicarboxylate transport system permease DctM subunit
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Electron transfer flavoprotein alpha/beta-subunit N-terminal
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
Methylene-tetrahydrofolate reductase C-terminal
Essential for prephenate dehydratase activity
Chromosomal replication initiator DnaA C-terminal
Cysteine sulfenic acid (-SOH) intermediate
RNA polymerase sigma factor 70 region 4 type 2
Acyl-CoA dehydrogenase C-terminal bacterial-type
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Secretin/TonB short N-terminal domain-containing protein
3-hydroxyisobutyrate dehydrogenase-like NAD-binding
6-phosphogluconate dehydrogenase NADP-binding
Transposase IS116/IS110/IS902 C-terminal
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
RND efflux pump membrane fusion protein barrel-sandwich
Ionotropic glutamate receptor C-terminal
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Ribosomal RNA adenine methylase transferase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Membrane fusion protein biotin-lipoyl like
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Pyruvate phosphate dikinase AMP/ATP-binding
Flagellar basal body rod protein N-terminal
Flagellar basal-body/hook protein C-terminal
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Large ribosomal subunit protein uL15/eL18
tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
Solute-binding protein family 3/N-terminal domain-containing protein
Membrane insertase YidC/Oxa/ALB C-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
S-adenosylmethionine-dependent methyltransferase
Bacterial bifunctional deaminase-reductase C-terminal
Signal transduction histidine kinase subgroup 3 dimerisation and phosphoacceptor
Pyrimidine nucleoside phosphorylase C-terminal
Periplasmic binding protein domain-containing protein
Bacteriophage capsid protein [General function prediction only]
DNA helicase Holliday junction RuvA type
Holliday junction DNA helicase RuvA C-terminal
Peptidase S9 prolyl oligopeptidase catalytic
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Endolytic peptidoglycan transglycosylase RlpA
RlpA-like protein double-psi beta-barrel
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Transcription elongation factor GreA/GreB C-terminal
Cytochrome c-type biogenesis protein CcmF C-terminal
Pseudouridine synthase I TruA alpha/beta
Beta-lactamase hydrolase-like protein phosphatase-like
2-oxoisovalerate dehydrogenase E1 alpha subunit N-terminal
N-end rule aminoacyl transferase C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Glycerol-3-phosphate dehydrogenase [NAD(P)+]
Beta-xylosidase C-terminal Concanavalin A-like
Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Glycosyltransferase subfamily 4-like N-terminal
Flagellar hook-length control protein-like C-terminal
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
Putative Flp pilus-assembly TadG-like N-terminal
Glycosyl transferase family 28 C-terminal
Glucose-methanol-choline oxidoreductase C-terminal
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Shikimate dehydrogenase substrate binding N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Pyridoxamine 5'-phosphate oxidase putative
Pyridoxine 5'-phosphate oxidase dimerisation C-terminal
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Methionyl-tRNA synthetase anticodon-binding
K(+)-insensitive pyrophosphate-energized proton pump
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
NAD(P) transhydrogenase alpha subunit C-terminal
Glycine cleavage T-protein C-terminal barrel
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Putative glycogen debranching enzyme N-terminal
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Mandelate racemase/muconate lactonizing enzyme C-terminal
O-(3'-phospho-DNA)-tyrosine intermediate
Ribulose bisphosphate carboxylase large subunit C-terminal
Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
NADH-rubredoxin oxidoreductase C-terminal
Nitrite/Sulfite reductase ferredoxin-like
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
CobB/CobQ-like glutamine amidotransferase
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
Prokaryotic-type class I peptide chain release factors
Anthranilate synthase component I N-terminal
Fructose-1-6-bisphosphatase class 1 C-terminal
Fructose-1-6-bisphosphatase class I N-terminal
Alpha-glycerophosphate oxidase C-terminal
Transcription regulator AsnC/Lrp ligand binding
Leucine-binding protein domain-containing protein
Phosphoadenosine phosphosulphate reductase
Ribose-phosphate pyrophosphokinase N-terminal
Plasmid replication protein C C-terminal
Plasmid replication protein C N-terminal
Important for beta-aspartyl-AMP intermediate formation
Bacterial transcription activator effector binding
Alpha-D-phosphohexomutase alpha/beta/alpha
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
L,D-transpeptidase catalytic domain-containing protein
Cytochrome c oxidase subunit IV bacterial aa3 type
Aerobactin siderophore biosynthesis IucA/IucC N-terminal
Aerobactin siderophore biosynthesis IucA/IucC-like C-terminal
Terminase large subunit gp17-like C-terminal
DNA mismatch repair proteins mutS family
Gamma-butyrobetaine hydroxylase-like N-terminal
Sodium symporter small subunit predicted
Chromosomal replication initiator protein DnaA
6-phosphogluconate dehydrogenase C-terminal
Glycine-rich cell wall structural protein
Na+/H+ antiporter MnhB subunit-related protein
Glucosamine/galactosamine-6-phosphate isomerase
Molybdopterin cofactor biosynthesis C (MoaC)
Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC
Polymerase/histidinol phosphatase N-terminal
RND efflux pump membrane fusion protein barrel-sandwich domain-containing protein
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Anaphase-promoting complex subunit 4-like WD40
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Phosphoribosylformylglycinamidine synthase linker
5-glutamyl coenzyme A thioester intermediate
Bacterial type II secretion system protein E
ATP-grasp fold succinyl-CoA synthetase-type
Flagellar motor switch protein FliG C-terminal
Flagellar motor switch protein FliG N-terminal
Flagellar motor switch protein FliG middle
Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like TPS
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
Poly-beta-hydroxybutyrate polymerase N-terminal
Septum formation inhibitor MinC C-terminal
Septum formation inhibitor MinC N-terminal
YbaK/aminoacyl-tRNA synthetase-associated
Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-96)
Release factor glutamine methyltransferase N-terminal
High-affinity branched-chain amino acid transport system permease LivHM N-terminal
Cytochrome C biogenesis protein transmembrane
PQQ-dependent catabolism-associated beta-propeller protein
Small ribosomal subunit protein uS4 N-terminal
Bacteriophage tail tape measure N-terminal
Could play a key role in the communication between the regulatory and the substrate sites
Increases nucleophilicity of active site Cys
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
ATP synthase F1 complex delta/epsilon subunit N-terminal
Phosphodiester glycosidase domain-containing protein
Aspartate/homoserine dehydrogenase NAD-binding
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Involved in allosteric activation by GTP
Outer membrane protein beta-barrel domain-containing protein
Signal transduction histidine kinase HWE region
Endoribonuclease L-PSP/chorismate mutase-like
Important for interaction with partner proteins
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Sodium/calcium exchanger membrane region
Nucleophile; cysteine thiosulfonate intermediate
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core
Flagellar motor switch protein FliN-like C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Survival protein SurE-like phosphatase/nucleotidase
Polysaccharide chain length determinant N-terminal
Probable periplasmic serine endoprotease DegP-like
Translation elongation factor P/YeiP central
Reversibly protonated during proton transport
DNA-directed DNA polymerase family A palm
Proton acceptor; specific for (R)-substrate epimerization
Proton acceptor; specific for (S)-substrate epimerization
Glycosyltransferase family 28 N-terminal
Guanylate kinase/L-type calcium channel beta subunit
RNA binding; important for wobble base 34 recognition
High-affinity zinc uptake system protein ZnuA
Phosphotransferase system enzyme I N-terminal
ABC transporter substrate-binding protein PnrA-like
Sugar fermentation stimulation protein C-terminal
Antitoxin Xre/MbcA/ParS-like toxin-binding
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Nucleophile; methyl group acceptor from either O6-methylguanine or O4-methylthymine
Nucleophile; methyl group acceptor from methylphosphotriester
Extensin-like C-terminal domain-containing protein
Type IV conjugative transfer protein TrbJ/K C-terminal
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Flagella basal body P-ring formation protein FlgA
Interaction with polymerase core subunit RpoC
Large ribosomal subunit protein uL6 alpha-beta
Acetyl-CoA hydrolase/transferase C-terminal
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
Tetrahydrodipicolinate-N-succinyltransferase chain A
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Alanyl-transfer RNA synthetases family profile
Glucose-6-phosphate dehydrogenase C-terminal
Glucose-6-phosphate dehydrogenase NAD-binding
Homogentisate 1,2-dioxygenase C-terminal
Homogentisate 1,2-dioxygenase N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Positions MEP for the nucleophilic attack
Carboxypeptidase regulatory-like domain-containing protein
Proline utilization A proline dehydrogenase N-terminal
SMODS-associated and fused to various effectors
Lyzozyme M1 (1,4-beta-N-acetylmuramidase)
Cytochrome b561 bacterial/Ni-hydrogenase
Superoxide dismutase copper/zinc binding
Large ribosomal subunit protein uL30-like ferredoxin-like fold
Glycosyl transferase family 3 N-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
TonB-dependent receptor-like beta-barrel
Histidine phosphotransferase ChpT C-terminal
PHA accumulation regulator DNA-binding N-terminal
Peptidase S11 D-Ala-D-Ala carboxypeptidase A C-terminal
serine-type D-Ala-D-Ala carboxypeptidase
Nitrogenase molybdenum-iron protein beta chain N-terminal
Proton acceptor; for glutaminase activity
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
tRNA pseudouridine synthase II TruB subfamily 1 C-terminal
tRNA pseudouridylate synthase B C-terminal