tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Phosphatidic acid phosphatase type 2/haloperoxidase
Important for catalytic activity for the proton relay mechanism but does not participate directly in the coordination of zinc atom
Prokaryotic-type class I peptide chain release factors
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
NAD(P) transhydrogenase alpha subunit C-terminal
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding
FAD-dependent oxidoreductase 2 FAD binding
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
RND efflux pump membrane fusion protein barrel-sandwich
S-adenosyl-L-homocysteine hydrolase NAD binding
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Flagellar motor switch protein FliN-like C-terminal
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
ATP synthase F1 complex delta/epsilon subunit N-terminal
Proton acceptor; for glutaminase activity
Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Hydroxymethylglutaryl-coenzyme A synthase N-terminal
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
6-hydroxymethylpterin diphosphokinase MptE-like
Polymerase/histidinol phosphatase N-terminal
Polysaccharide biosynthesis protein CapD-like
SUF system FeS cluster assembly SufBD N-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
ATPsynthase alpha/beta subunit N-terminal extension
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Aminoacyl-transfer RNA synthetases class-II family profile
Calcium/calmodulin-dependent protein kinase II association-domain
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Right handed beta helix domain-containing protein
Peptidase S11 D-alanyl-D-alanine carboxypeptidase A N-terminal
Gamma-butyrobetaine hydroxylase-like N-terminal
NIF system FeS cluster assembly NifU C-terminal
NIF system FeS cluster assembly NifU N-terminal
Gly-cisPro motif, important for rejection of L-amino acids
Plays an important role in substrate specificity
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
S-adenosylmethionine-dependent methyltransferase
Cobalamin-independent methionine synthase MetE C-terminal/archaeal
Large ribosomal subunit protein uL6 alpha-beta
Thiamine pyrophosphate enzyme N-terminal TPP-binding
NADPH-dependent 7-cyano-7-deazaguanine reductase N-terminal
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
DNA-directed RNA polymerase RpoA/D/Rpb3-type
Major facilitator superfamily (MFS) profile
Peptidase C14 caspase domain-containing protein
Helix-hairpin-helix DNA-binding motif class 1
Signal recognition particle SRP54 helical bundle
Glucose-6-phosphate dehydrogenase assembly protein OpcA C-terminal
Glucose-6-phosphate dehydrogenase assembly protein OpcA N-terminal
Glycoside hydrolase family 65 C-terminal
Glycoside hydrolase family 65 N-terminal
Glycoside hydrolase family 65 central catalytic
Pseudouridine synthase I TruA alpha/beta
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
O-(5'-phospho-DNA)-tyrosine intermediate
RNA 2-O ribose methyltransferase substrate binding
Membrane insertase YidC/Oxa/ALB C-terminal
Heat-inducible transcription repressor HrcA C-terminal
Outer-membrane lipoprotein Wza C-terminal
Glucan biosynthesis periplasmic MdoG C-terminal
Flagellar assembly protein FliH/Type III secretion system HrpE
Shikimate dehydrogenase substrate binding N-terminal
Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Chalcone isomerase domain-containing protein
Sporulation stage II protein D amidase enhancer LytB N-terminal
Influences the redox potential of the prosthetic heme and FAD groups
Involved in heme-bound ligand stabilization and O-O bond activation
Alpha-D-phosphohexomutase alpha/beta/alpha
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Reversibly protonated during proton transport
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
Cobalamin-independent methionine synthase MetE N-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
HPr(Ser) kinase/phosphorylase N-terminal
Important for the catalytic mechanism of both phosphorylation and dephosphorylation
Important for the catalytic mechanism of dephosphorylation
Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
DNA-directed DNA polymerase family A palm
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
UDP N-acetylglucosamine O-acyltransferase C-terminal
tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Urease accessory protein UreH-like transmembrane
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
RNA binding; important for wobble base 34 recognition
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Schiff-base intermediate with D-ribose 5-phosphate
Putative regulatory protein FmdB Zinc ribbon
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
YbaK/aminoacyl-tRNA synthetase-associated
Solute-binding protein family 3/N-terminal
Translation elongation factor P/YeiP central
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
Large ribosomal subunit protein uL15/eL18
Glycosyltransferase subfamily 4-like N-terminal
Superoxide dismutase copper/zinc binding
Glucosamine/galactosamine-6-phosphate isomerase
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Penicillin-binding protein transpeptidase
Tryptophan synthase beta chain-like PALP
Prolyl 4-hydroxylase alpha subunit Fe(2+) 2OG dioxygenase
Outer membrane protein beta-barrel domain-containing protein
Interaction with polymerase core subunit RpoC
Quinolinate phosphoribosyl transferase C-terminal
Quinolinate phosphoribosyl transferase N-terminal
Sigma 54 modulation/S30EA ribosomal protein C-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
Large ribosomal subunit protein bL9 C-terminal
Outer membrane lipoprotein BamD-like domain-containing protein
Endonuclease/exonuclease/phosphatase domain-containing protein
Na(+)-translocating NADH-quinone reductase subunit A C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Large ribosomal subunit protein uL2 C-terminal
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Ribose-phosphate pyrophosphokinase N-terminal
Chromosomal replication initiator DnaA C-terminal
Small ribosomal subunit protein uS4 N-terminal
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Hypersensitivity response secretion-like HrpJ
Cytochrome b/b6 N-terminal region profile
Could be important to modulate the pK values of the two catalytic cysteine residues
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Exonuclease VII large subunit C-terminal
Thiamine pyrophosphate enzyme TPP-binding
tRNA pseudouridylate synthase B C-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Alanyl-transfer RNA synthetases family profile
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Charge relay system; for autoendoproteolytic cleavage activity
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity
O-(3'-phospho-DNA)-tyrosine intermediate
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Release factor glutamine methyltransferase N-terminal
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Survival protein SurE-like phosphatase/nucleotidase
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
non-specific serine/threonine protein kinase
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose