Major facilitator superfamily (MFS) profile
TRAP C4-dicarboxylate transport system permease DctM subunit
HicB-like antitoxin of toxin-antitoxin system
Transposase IS116/IS110/IS902 C-terminal
Transcription elongation factor GreA/GreB C-terminal
Transcription elongation factor GreA/GreB N-terminal
NADH:quinone oxidoreductase/Mrp antiporter membrane subunit
CASTOR/POLLUX/SYM8 ion channel conserved
RND efflux pump membrane fusion protein barrel-sandwich
Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding
Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Polysaccharide chain length determinant N-terminal
Pyruvate flavodoxin/ferredoxin oxidoreductase pyrimidine binding
NADH:flavin oxidoreductase/NADH oxidase N-terminal
Membrane insertase YidC/Oxa/ALB C-terminal
Pyridine nucleotide-disulphide oxidoreductase dimerisation
Pyruvate/ketoisovalerate oxidoreductase catalytic
Resolvase/invertase-type recombinase catalytic
Aldehyde oxidase/xanthine dehydrogenase a/b hammerhead
Lipocalin-like domain-containing protein
Aminoacyl-transfer RNA synthetases class-II family profile
Acyl-CoA dehydrogenase/oxidase C-terminal
Acyl-CoA dehydrogenase/oxidase N-terminal
Alpha-D-phosphohexomutase alpha/beta/alpha
Large ribosomal subunit protein bL25 L25
Large ribosomal subunit protein bL25 beta
Plays an important role in substrate specificity
Membrane iron-sulfur containing protein FtrD-like
DNA/pantothenate metabolism flavoprotein C-terminal
Phosphopantothenoylcysteine decarboxylase
Glycosyltransferase subfamily 4-like N-terminal
PilC beta-propeller domain-containing protein
Solute-binding protein family 3/N-terminal
S-adenosylmethionine synthetase C-terminal
S-adenosylmethionine synthetase N-terminal
NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal
NADH:ubiquinone/plastoquinone oxidoreductase chloroplast chain 5 C-terminal
NADH:ubiquinone oxidoreductase 30kDa subunit
Important for substrate specificity; cannot use PPi as phosphoryl donor
Membrane fusion protein biotin-lipoyl like
NIF system FeS cluster assembly NifU N-terminal
NIF system FeS cluster assembly NifU C-terminal
Fe-S hydro-lyase tartrate dehydratase beta-type catalytic
Pyruvate phosphate dikinase AMP/ATP-binding
Important for beta-aspartyl-AMP intermediate formation
Phosphatidic acid phosphatase type 2/haloperoxidase
Protochlamydia outer membrane protein domain-containing protein
Glycoside hydrolase family 57 N-terminal
Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding
Survival protein SurE-like phosphatase/nucleotidase
Acetyl-CoA hydrolase/transferase C-terminal
Acetyl-CoA hydrolase/transferase N-terminal
ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase
Outer membrane protein beta-barrel domain-containing protein
CobB/CobQ-like glutamine amidotransferase
D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding
D-isomer specific 2-hydroxyacid dehydrogenase catalytic
Peptidase M1 alanyl aminopeptidase C-terminal
Peptidase M1 alanyl aminopeptidase Ig-like fold
Peptidase M1 membrane alanine aminopeptidase
Ribonucleotide reductase class II vitamin B12-dependent N-terminal
Ribonucleotide reductase large subunit C-terminal
PsbP C-terminal domain-containing protein
O-(5'-phospho-DNA)-tyrosine intermediate
Ribosome maturation factor RimP C-terminal
Ribosome maturation factor RimP N-terminal
Late embryogenesis abundant protein LEA-2 subgroup domain-containing protein
Electron transfer flavoprotein alpha/beta-subunit N-terminal
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Alanyl-transfer RNA synthetases family profile
Cytochrome b/b6 C-terminal region profile
Cytochrome b/b6 N-terminal region profile
3-hydroxyacyl-CoA dehydrogenase C-terminal
3-hydroxyacyl-CoA dehydrogenase NAD binding
Thiamine pyrophosphate enzyme N-terminal TPP-binding
Thiamine pyrophosphate enzyme TPP-binding
RNA 2-O ribose methyltransferase substrate binding
Involved in Mg(2+) ion dislocation from EF-Tu
Translation elongation factor EFTs/EF1B dimerisation
Activator of Hsp90 ATPase homologue 1-like C-terminal
TonB-dependent receptor-like beta-barrel
Homocysteine biosynthesis enzyme sulfur-incorporation
tRNA-specific 2-thiouridylase MnmA-like C-terminal
tRNA-specific 2-thiouridylase MnmA-like central
Phosphoenolpyruvate carboxykinase C-terminal P-loop
Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
F420-non-reducing hydrogenase iron-sulfur subunit D
RNA 3'-terminal phosphate cyclase insert
Prepilin type IV endopeptidase peptidase
Acetyl-CoA dehydrogenase-like C-terminal
Acyl-CoA dehydrogenase N-terminal bacteria
Haem-binding uptake Tiki superfamily ChaN
Aconitase A/isopropylmalate dehydratase small subunit swivel
Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha
Gamma-glutamylcyclotransferase AIG2-like
Large ribosomal subunit protein uL30-like ferredoxin-like fold
P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein
Aspartate/ornithine carbamoyltransferase Asp/Orn-binding
Aspartate/ornithine carbamoyltransferase carbamoyl-P binding
RNA polymerase sigma factor 70 region 4 type 2
Acetylserotonin O-methyltransferase dimerisation
NADH:ubiquinone oxidoreductase-like 20kDa subunit
O-(3'-phospho-DNA)-tyrosine intermediate
Tryptophan synthase beta chain-like PALP
NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding
UDP-glucose/GDP-mannose dehydrogenase C-terminal
Large ribosomal subunit protein uL11 C-terminal
Large ribosomal subunit protein uL11 N-terminal
Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding
Aminoacyl-tRNA synthetase class I anticodon-binding
Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic
Arsenosugar biosynthesis radical SAM protein ArsS-like C-terminal
Aldehyde oxidase/xanthine dehydrogenase second molybdopterin binding
Pyridoxamine kinase/Phosphomethylpyrimidine kinase
DNA polymerase III beta sliding clamp C-terminal
DNA polymerase III beta sliding clamp N-terminal
DNA polymerase III beta sliding clamp central
Positions MEP for the nucleophilic attack
Fe-S hydro-lyase tartrate dehydratase alpha-type catalytic
Bacterial type II secretion system protein E
Ribosomal RNA adenine methylase transferase N-terminal
Methylene-tetrahydrofolate reductase C-terminal
Glycosyl transferase family 3 N-terminal
2-(S-cysteinyl)pyruvic acid O-phosphothioketal
S-adenosyl-L-homocysteine hydrolase NAD binding
Translation initiation factor 3 C-terminal
Translation initiation factor 3 N-terminal
Aspartate carbamoyltransferase regulatory subunit C-terminal
Aspartate carbamoyltransferase regulatory subunit N-terminal
Increases nucleophilicity of active site Cys
FAD-dependent oxidoreductase 2 FAD binding
Cysteine sulfenic acid (-SOH) intermediate
Polysaccharide biosynthesis protein CapD-like
Saccharopine dehydrogenase-like C-terminal
Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA
Aldehyde ferredoxin oxidoreductase N-terminal
Mannose-6-phosphate isomerase type II C-terminal
L,D-transpeptidase catalytic domain-containing protein
Polymerase/histidinol phosphatase N-terminal
N-(5'phosphoribosyl) anthranilate isomerase (PRAI)
Gly-cisPro motif, important for rejection of L-amino acids
Trigger factor ribosome-binding bacterial
Ribose-phosphate pyrophosphokinase N-terminal
Tripartite tricarboxylate transporter substrate binding protein
Penicillin-binding protein transpeptidase
Cation-transporting P-type ATPase N-terminal
Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose
Sigma 54 modulation/S30EA ribosomal protein C-terminal
Nucleophile; for GTP cyclohydrolase activity
Proton acceptor; for GTP cyclohydrolase activity
Peptidase S9 prolyl oligopeptidase catalytic
Beta-ketoacyl-[acyl-carrier-protein] synthase III N-terminal
Reversibly protonated during proton transport
DNA replication/recombination mediator RecO N-terminal
Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY
Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding
Helix-hairpin-helix DNA-binding motif class 1
Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal
Heme-copper oxidase subunit III family profile
Type ISP restriction-modification enzyme LLaBIII C-terminal specificity
Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal
Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding
Cytochrome c-552/4 domain-containing protein
Cleavage (non-hydrolytic); by autocatalysis
Phosphatidylserine decarboxylase alpha chain
Phosphatidylserine decarboxylase beta chain
Schiff-base intermediate with substrate; via pyruvic acid
Pyridoxamine 5'-phosphate oxidase putative
D-galactarate/Altronate dehydratase C-terminal
DNA-directed DNA polymerase family A palm
DNA primase/polymerase bifunctional N-terminal
Glutamate-ammonia ligase adenylyltransferase repeated
PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase
DNA-directed RNA polymerase beta subunit external 1
DNA-directed RNA polymerase subunit 2 hybrid-binding
Ysc84 actin-binding domain-containing protein
Molybdopterin-guanine dinucleotide biosynthesis protein B (MobB)
ATP synthase F1 complex delta/epsilon subunit N-terminal
Large ribosomal subunit protein uL2 C-terminal
Arginine biosynthesis bifunctional protein ArgJ alpha chain
Arginine biosynthesis bifunctional protein ArgJ beta chain
Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Lysozyme inhibitor LprI N-terminal domain-containing protein
Could be important to modulate the pK values of the two catalytic cysteine residues
Nicotinate phosphoribosyltransferase C-terminal
Nicotinate phosphoribosyltransferase N-terminal
Nicotinate/nicotinamide phosphoribosyltransferase
Putative regulatory protein FmdB Zinc ribbon
Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM
Shikimate dehydrogenase substrate binding N-terminal
Pyruvate ferredoxin oxidoreductase beta subunit C-terminal
Translation elongation factor P/YeiP central
Tetrapyrrole biosynthesis uroporphyrinogen III synthase
Large ribosomal subunit protein bL12 C-terminal
Large ribosomal subunit protein bL12 oligomerization
Ribosomal RNA small subunit methyltransferase E PUA-like
Ribosomal RNA small subunit methyltransferase E methyltransferase
Schiff-base intermediate with D-ribose 5-phosphate
Prokaryotic-type class I peptide chain release factors
Exonuclease VII large subunit C-terminal
Phosphatidylglycerol lysyltransferase C-terminal
Large ribosomal subunit protein uL5 C-terminal
Large ribosomal subunit protein uL5 N-terminal
Polysaccharide biosynthesis protein C-terminal
Siroheme decarboxylase AsnC-like ligand binding
L-seryl-tRNA selenium transferase N-terminal
Chromosomal replication initiator DnaA C-terminal
tRNA pseudouridylate synthase B C-terminal
RNA polymerase sigma factor 54 DNA-binding
RNA polymerase sigma factor 54 core-binding
Small ribosomal subunit protein uS4 N-terminal
Essential for prephenate dehydratase activity
Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal
Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase non-repeat region
Pseudouridine synthase I TruA alpha/beta
Phosphodiester glycosidase domain-containing protein
Pyrroline-5-carboxylate reductase catalytic N-terminal
Pyrroline-5-carboxylate reductase dimerisation
Damage-control phosphatase ARMT1-like metal-binding
Gfo/Idh/MocA-like oxidoreductase C-terminal
Gfo/Idh/MocA-like oxidoreductase N-terminal
Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-96)
Iron dependent repressor metal binding and dimerisation
Glycosyl transferase family 28 C-terminal
Glycosyltransferase family 28 N-terminal
Histidine-specific methyltransferase SAM-dependent
Cytochrome oxidase subunit II copper A binding
Cytochrome oxidase subunit II transmembrane region profile
ABC-type uncharacterised transport system
Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal
Transcription factor NikR nickel binding C-terminal
Cytochrome C biogenesis protein transmembrane
Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP
Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi
Release factor glutamine methyltransferase N-terminal
Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity
1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
1-deoxy-D-xylulose 5-phosphate reductoisomerase N-terminal
6-phosphogluconate dehydrogenase C-terminal
tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain
Carbamoyl-phosphate synthase small subunit N-terminal
Phosphoribosylformylglycinamidine synthase linker
Cytochrome b561 bacterial/Ni-hydrogenase
Manganese/iron superoxide dismutase C-terminal
Manganese/iron superoxide dismutase N-terminal
Exosortase system-associated protein, TIGR04073 family
Proton acceptor; for glutaminase activity
RNA binding; important for wobble base 34 recognition
Urease accessory protein UreH-like transmembrane
Dinitrogenase iron-molybdenum cofactor biosynthesis
Dihydrodipicolinate reductase C-terminal
Dihydrodipicolinate reductase N-terminal
UDP N-acetylglucosamine O-acyltransferase C-terminal
Inner membrane protein YgaP-like transmembrane
Formylmethanofuran dehydrogenase subunit E
Molybdopterin cofactor biosynthesis C (MoaC)
Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
Tetrapyrrole biosynthesis glutamyl-tRNA reductase dimerisation
Large ribosomal subunit protein uL15/eL18
Important for interaction with partner proteins
Succinate dehydogenase/fumarate reductase N-terminal
CO dehydrogenase/acetyl-CoA synthase complex beta subunit C-terminal
Carbon monoxide dehydrogenase subunit alpha ,N-terminal
3-deoxy-D-manno-octulosonic-acid transferase N-terminal
Interaction with polymerase core subunit RpoC
NADH:ubiquinone oxidoreductase chain 4 N-terminal
Heat-inducible transcription repressor HrcA C-terminal
Large ribosomal subunit protein uL6 alpha-beta
ATPase F1/V1/A1 complex alpha/beta subunit N-terminal
ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding